CN105853579A - Pharmaceutical composition for treating varicosity and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of traditional Chinese medicine application, and particularly relates to a pharmaceutical composition for treating varicosity and a preparation method thereof. For overcoming the defects that when existing medicine is used for treating the varicosity, the effects are slow to achieve, the treatment effect is poor, and certain toxic and side effects are generated, the traditional Chinese medicine composition is prepared from, by weight, 150-200 parts of milkvetch roots, 10-20 parts of radix angelica sinensis, 10-20 parts of radix rehmanniae, 15-25 parts of semen persicae 10-20 parts of flos carthami, 5-15 parts of fructus aurantii, 5-15 parts of radix paeoniae rubra, 8-15 parts of radix bupleuri, 5-15 parts of licorice roots, 5-15 parts of radix platycodi, 10-15 parts of radix achyranthis bidentatae, 30-50 parts of radix achyranthis bidentatae, 30-50 parts of lumbricus, 8-15 parts of rhizoma chuanxiong and 10-20 parts of centipedes. The pharmaceutical composition can promote blood circulation to remove blood stasis, attack toxicity to eliminate stagnation and effectively improve blood microcirculation, has the miraculous effect on the varicosity and is poisonless and harmless. The high-quality traditional Chinese medicine composition is supplied to the varicosity.

Description

One treats cirsoid pharmaceutical composition and preparation method thereof

Technical field

The invention belongs to application in TCM technical field, be specifically related to one and treat cirsoid pharmaceutical composition and preparation side thereof Method.

Background technology

Varication is common disease and the frequently-occurring disease of vascular surgery, is especially more common in and is engaged in lasting manual labor or work of standing Personnel.Mainly show as the expansion of lower limb superficial vein, extend, tortuous, the symptoms such as generation suffering limb acid is swollen, weak, heavy, Severe patient is often accompanied by the complication such as ulcus cruris or superficial phlebitis.

Varix of lower limb is due to hypostasis, and the factors such as vein tube wall is weak cause veins of lower extremity tortuous, expansion, mesh Front western medicine therapy is many with operation, thrombolysis anti-inflammatory etc., the traditional Chinese medical science multiplex Orally taken and externally therapy, disease be there is no in early days to preferably treatment Method.In theory of traditional Chinese medical science, varix of lower limb belongs to motherland's medical science " superficial phlebangioma ", the category of " knee sore ", and its interpretation of the cause, onset and process of an illness is prolonged standing Or undertake weight, tired wasting QI-blood；Or the sinking of qi of middle-jiao, train of thought lose smooth, the QI-blood circulation of impact local, addiction blood delay in Among channels, qi stagnation hemagglutination forms；Multiple because of damp invasion of lower energizer, toxin stimulates skin to make pruitus, so being grabbed by finger nail Broken, and the virus such as eczema infects and induced ulcer.

Treat cirsoid medicament categories at present various, but some medicine yin-damaging and Qi consuming, damage blood vessels, toxic and side effect is big, Unsuitable Long-Time Service；Or effect is slow, brings considerable distress to patient.

Summary of the invention

For the problems referred to above, the goal of the invention of the present invention is to provide a kind of evident in efficacy, instant effect and nontoxic special In treating cirsoid pharmaceutical composition and preparation method thereof.

First technical problem that the invention solves the problems that is to provide one and treats cirsoid pharmaceutical composition.Its raw material cartridge bag Include the composition of following weight parts: Radix Astragali 150-200 part, Radix Angelicae Sinensis 10-20 part, dried rhizome of rehmannia 10-20 part, peach kernel 15-25 part, Safflower 10-20 part, long-pending shell 5-15 part, radix paeoniae rubrathe 5-15 part, radix bupleuri 8-15 part, Radix Glycyrrhizae 5-15 part, balloonflower root 5-15 part, Root of bidentate achyranthes 10-15 part, earthworm 30-50 part, rhizome of chuanxiong 8-15 part, centipede 10-20 part.

Preferably, in the cirsoid pharmaceutical composition of above-mentioned treatment, bulk drug includes the composition of following weight parts: the Radix Astragali 150 parts, Radix Angelicae Sinensis 15 parts, 15 parts of the dried rhizome of rehmannia, 20 parts of peach kernel, 15 parts of safflower, long-pending 10 parts of shell, the radix paeoniae rubrathe 10 parts, radix bupleuri 10 parts, 10 parts of Radix Glycyrrhizae, balloonflower root 10 parts, the root of bidentate achyranthes 10 parts, earthworm 40 parts, rhizome of chuanxiong 10 parts, centipede 15 parts.

Wherein, in the cirsoid pharmaceutical composition of above-mentioned treatment, described pharmaceutical composition is on the basis of bulk drug, presses More solito makes oral formulations；Or add pharmaceutically acceptable auxiliary material and make conventional oral formulations.

Preferably, in the cirsoid pharmaceutical composition of above-mentioned treatment, described oral formulations be powder, tablet, granule, Capsule or oral liquid.

Second technical problem that the invention solves the problems that is to provide the preparation of a kind of cirsoid pharmaceutical composition of above-mentioned treatment Method.Including following methods:

Method one: each bulk drug is ground into fine powder, mixing powder；Or

Method two: each bulk drug is ground into fine powder, encapsulated capsule；Or

Method three: each bulk drug is ground into fine powder, compressing tablet i.e. piece agent；Or

Method four: after each bulk drug water boiling and extraction, concentrated extracting solution makes particle, granule；Or

Method five: after each bulk drug water boiling and extraction, concentrated extracting solution makes particle, encapsulated capsule；Or

Method six: after each bulk drug water boiling and extraction, concentrated extracting solution makes particle, compressing tablet i.e. piece agent；Or

Method seven: after each bulk drug water boiling and extraction, make oral liquid.

The invention have the benefit that medicine of the present invention has clearing heat and detoxicating, invigorate blood circulation and stimulate the menstrual flow, going stasis of blood pain relieving, promoting the circulation of qi is opened strongly fragrant, Dissipate blood detumescence, the function of promoting pus discharge and tissue regeneration, by cooperating between medicine and medicine, select the medicine of different content scope Act synergistically such that it is able to effectively treat varication.Medicine composite for curing varication of the present invention is simple, Evident in efficacy, instant effect, and have no side effect, open a new road for treatment varication.

Detailed description of the invention

The invention provides one and treat cirsoid pharmaceutical composition, its bulk drug includes the composition of following weight parts: yellow Stilbene 150-200 part, Radix Angelicae Sinensis 10-20 part, dried rhizome of rehmannia 10-20 part, peach kernel 15-25 part, safflower 10-20 part, long-pending shell 5-15 Part, radix paeoniae rubrathe 5-15 part, radix bupleuri 8-15 part, Radix Glycyrrhizae 5-15 part, balloonflower root 5-15 part, root of bidentate achyranthes 10-15 part, earthworm 30-50 Part, rhizome of chuanxiong 8-15 part, centipede 10-20 part.

Preferably, in the above-mentioned cirsoid pharmaceutical composition for the treatment of, bulk drug includes the composition of following weight parts: yellow Stilbene 150 parts, Radix Angelicae Sinensis 15 parts, 15 parts of the dried rhizome of rehmannia, 20 parts of peach kernel, 15 parts of safflower, long-pending 10 parts of shell, the radix paeoniae rubrathe 10 parts, bavin 10 parts recklessly, 10 parts of Radix Glycyrrhizae, balloonflower root 10 parts, the root of bidentate achyranthes 10 parts, earthworm 40 parts, rhizome of chuanxiong 10 parts, centipede 15 parts.

In the present invention, the Radix Astragali has invigorating qi for strengthening superficies, and diuresis torr is malicious, apocenosis, and effect of expelling pus and promoting granulation is weak for the deficiency of vital energy, Anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer difficulty is burst, and bursts for a long time and does not holds back, and the deficiency of blood is sallow, Interior heat such as is quenched one's thirst the disease；

Radix Angelicae Sinensis has replenishing and activating blood, menstruction regulating and pain relieving, the effect relaxed bowel, sallow for the deficiency of blood, dizziness palpitaition, and menstruation is not Adjust, through closing dysmenorrhoea, asthenia cold abdominalgia, the dry constipation of intestines, arthralgia due to wind-dampness, injury from falling down, the disease such as ulcer sores；

The dried rhizome of rehmannia have heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new, pain relieving, menstruation regulating, the metal-inflicted wound stasis of blood, cool blood, hemostasis Effect；

Peach kernel has promoting blood circulation, relaxes bowel, relieving cough and asthma effect, is used for through closing dysmenorrhoea, lump in the abdomen lump in the abdomen lump in the abdomen, lung carbuncle intestines Carbuncle, injury from falling down, the dry constipation of intestines, the disease such as cough and asthma；

Safflower has to invigorate blood circulation and stimulates the menstrual flow, effect of blood stasis removing analgesic, for through closing, and dysmenorrhoea, lochia, abdominal mass lump in the abdomen, fall and flutter Damage, sore such as swells and ache the disease；

Long-pending shell has a regulating the flow of QI to ease the stomach, effect of the stagnant dissipate-swelling of row, stagnant for chest diaphragm phlegm, and the feeling of stuffiness in chest is coerced swollen, dyspepsia, and gas is vomitted Inverse, weight after diarrhea, prolapse of the anus, the disease such as the prolapse of uterus；

The radix paeoniae rubrathe has clearing heat and cooling blood, effect of promoting blood circulation, for the stasis of blood stagnant through closing, the accumulation of hernia lump in the abdomen, stomachache, hypochondriac pain, bleeding from five sense organs or subcutaneous tissue, The diseases such as bloody flux, discharging fresh blood stool, hot eyes, carbuncle are swollen, injury from falling down；

Radix bupleuri has table and expels the heat-evil, soothing liver-qi stagnation, rises the effect lifting yang-energy, for stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, The diseases such as uterus comes off, irregular menstruation；

Radix Glycyrrhizae has invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, effect of coordinating the drug actions of a prescription, empty for taste Weak, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, Strong；

Balloonflower root has out a surname's lung qi, the effect of apocenosis of eliminating the phlegm, for abscess of throat, lung carbuncle pyemesis, fullness in the chest and hypochondriac pain, dysentery abdomen The diseases such as pain；

The root of bidentate achyranthes have promoting blood circulation, filling liver kidney, strengthening the bones and muscles, invigorate blood circulation stimulate the menstrual flow, ignite (blood) descending, effect of inducing diuresis for treating strangurtia；

Earthworm has heat-clearing, flat liver, Zhichuan, effect of dredging collateral, for high fanatical dry, and convulsion, headache due to pathogenic wind-heat, mesh The diseases such as red, hemiplegia；

Ligusticum wallichii has promoting blood circulation, strongly fragrant, effect of wind-expelling pain-stopping is opened in promoting the circulation of qi；

Centipede has breath wind antispastic, dispersing pathogen accumulation, effect of removing obstruction in channels to relieve pain；

Said medicine, through long-term test, has been carried out suitable proportioning by inventor, utilizes the synergy between medicine, reaches To promoting blood circulation and removing blood stasis, the effect of heat radiation pain relieving, this pharmaceutical composition is notable to varicose treatment effect, instant effect, and has no Toxic and side effect.

Below by embodiment, technical scheme is described further, but the technology contents of the present invention is not limited In the range of described in embodiment.Embodiment uses oral liquid formulation.

Embodiment 1

Weigh: Radix Astragali 150g, Radix Angelicae Sinensis 10g, dried rhizome of rehmannia 10g, peach kernel 15g, safflower 10g, long-pending shell 5g, radix paeoniae rubrathe 5g, radix bupleuri 8g, Radix Glycyrrhizae 5g, balloonflower root 5g, root of bidentate achyranthes 10g, earthworm 30g, rhizome of chuanxiong 8g, centipede 10g, after each bulk drug water boiling and extraction, system Become oral liquid, obtain medicament 1.

Embodiment 2

Weigh: Radix Astragali 200g, Radix Angelicae Sinensis 20g, dried rhizome of rehmannia 20g, peach kernel 25g, safflower 20g, long-pending shell 15g, radix paeoniae rubrathe 15g, Radix bupleuri 15g, Radix Glycyrrhizae 15g, balloonflower root 15g, root of bidentate achyranthes 15g, earthworm 50g, rhizome of chuanxiong 15g, centipede 20g, by each bulk drug After water boiling and extraction, make oral liquid, obtain medicament 2.

Embodiment 3

Weigh: Radix Astragali 150g, Radix Angelicae Sinensis 15g, dried rhizome of rehmannia 15g, peach kernel 20g, safflower 15g, long-pending shell 10g, radix paeoniae rubrathe 10g, Radix bupleuri 10g, Radix Glycyrrhizae 10g, balloonflower root 10g, root of bidentate achyranthes 10g, earthworm 40g, rhizome of chuanxiong 10g, centipede 15g, by each bulk drug After water boiling and extraction, make oral liquid, obtain medicament 3.

Illustrate that the present invention treats the beneficial effect of cirsoid pharmaceutical composition below by test example.

Test example

Randomly select varication middle and later periods patient 150 people, be divided into 3 groups, often organize 50 people, often organize take respectively medicament 1, 2,3, every day twice, take after lunch, dinner, when treating 7-14 days, observe patient every day, according to sense organ Pass judgment on medication effect.

Evaluation index: invalid: CT vein is slow according to venous blood flow seen from shadow, the ulcer of lower limb, fester, the open sore part is difficult to heal； Effective: CT vein is accelerated according to venous blood flow seen from shadow, and the open sore part substantially heals, swelling, pain, weakness of the lower extremities, numbness, The symptom such as sending out cool disappears substantially, and black purple, the skin of scleroma tend to normal；Cure: CT vein is smooth according to venous blood seen from shadow Logical, blood viscosity, platelet aggregation are remarkably decreased and recover normal value, and dead skin starts to grow normal skin, black Skin purple, scleroma recovers smooth and elastic.

Result of the test is as shown in table 1 below:

The different medicament of table 1 is to cirsoid result for the treatment of

	Cure rate	Efficient	Healing time/sky
				Medicament 1	90	94	10
Medicament 2	92	96	9
				Medicament 3	96	98	7

Model case

Zhu, female, 62 years old.Double varixs of lower limb more than 4 years, during erect position, the visible bending of leg increases thick superficial vein Blood vessel, exceeds skin, can disappear, often have swollen, the fatiguability of shank acid etc. after leg is raised or put down and crouches.Over nearly two months left Lower limb local skin is rubescent, purpling, red tongue body, and tongue is the thickest greasy, deep-slow pulse.Take this Chinese medicine composition, pain after one week Basic disappearance, the blood vessel protrusion exceeding skin alleviates.Take again one week, if all diseases are lost.Continue to take one week and consolidate curative effect.

Claims (5)

1. treat cirsoid pharmaceutical composition for one kind, it is characterised in that bulk drug includes the composition of following weight parts: yellow Stilbene 150-200 part, Radix Angelicae Sinensis 10-20 part, dried rhizome of rehmannia 10-20 part, peach kernel 15-25 part, safflower 10-20 part, long-pending shell 5-15 part, Radix paeoniae rubrathe 5-15 part, radix bupleuri 8-15 part, Radix Glycyrrhizae 5-15 part, balloonflower root 5-15 part, root of bidentate achyranthes 10-15 part, earthworm 30-50 part, Rhizome of chuanxiong 8-15 part, centipede 10-20 part.

The cirsoid pharmaceutical composition for the treatment of the most according to claim 1, it is characterised in that bulk drug includes following The composition of weight portion: the Radix Astragali 150 parts, Radix Angelicae Sinensis 15 parts, 15 parts of the dried rhizome of rehmannia, 20 parts of peach kernel, 15 parts of safflower, long-pending 10 parts of shell, The radix paeoniae rubrathe 10 parts, radix bupleuri 10 parts, 10 parts of Radix Glycyrrhizae, balloonflower root 10 parts, the root of bidentate achyranthes 10 parts, earthworm 40 parts, rhizome of chuanxiong 10 parts, Wu Centipede 15 parts.

The cirsoid pharmaceutical composition for the treatment of the most according to claim 1, it is characterised in that described pharmaceutical composition For on the basis of bulk drug, conventionally make oral formulations；Or add pharmaceutically acceptable auxiliary material and make conventional Oral formulations.

The cirsoid pharmaceutical composition for the treatment of the most according to claim 1, it is characterised in that: described oral formulations is Powder, tablet, granule, capsule or oral liquid.

The preparation method of the cirsoid pharmaceutical composition for the treatment of the most according to claim 1, it is characterised in that:

Method one: each bulk drug is ground into fine powder, mixing powder；Or

Method two: each bulk drug is ground into fine powder, encapsulated capsule；Or

Method three: each bulk drug is ground into fine powder, compressing tablet i.e. piece agent；Or

Method four: after each bulk drug water boiling and extraction, concentrated extracting solution makes particle, granule；Or

Method five: after each bulk drug water boiling and extraction, concentrated extracting solution makes particle, encapsulated capsule；Or

Method six: after each bulk drug water boiling and extraction, concentrated extracting solution makes particle, compressing tablet i.e. piece agent；Or

Method seven: after each bulk drug water boiling and extraction, make oral liquid.