CN105832655A - Composition for promoting wound healing and effectively inhibiting scar formation and application thereof - Google Patents
Composition for promoting wound healing and effectively inhibiting scar formation and application thereof Download PDFInfo
- Publication number
- CN105832655A CN105832655A CN201610168882.1A CN201610168882A CN105832655A CN 105832655 A CN105832655 A CN 105832655A CN 201610168882 A CN201610168882 A CN 201610168882A CN 105832655 A CN105832655 A CN 105832655A
- Authority
- CN
- China
- Prior art keywords
- white sugar
- oxytetracycline
- pharmaceutical composition
- composition
- wound healing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a composition for promoting wound healing and effectively inhibiting scar formation and an application thereof. The pharmaceutical composition is composed of (by weight): 1 part of terramycin or its pharmaceutically acceptable salt, 2-3 parts of white sugar and 3-5 parts of soya-bean oil. The preparation method comprises the following steps: (1) crushing terramycin and sieving through a 100-mesh sieve; (2) crushing white sugar and sieiving through a 100-mesh sieve; (3) weighing terramycin, white sugar and soya-bean oil according to the mass ratio, and uniformly stirring terramycin and white sugar with soya-bean oil; and (4) carrying out moist heat sterilization on the uniformly-stirred pharmaceutical composition at 121 DEG C for 30 min, and finally carrying out sterile filling by the use of a brown glass bottle which has undergone asepsis so as to obtain the pharmaceutical composition. By the above formula, the composition can prevent infection and minimize ache for sharp instrument injury by knife-cutting, postoperative wound and the like, and remarkably inhibits scar formation during wound healing process.
Description
Technical field
The present invention relates to a kind of quickening sharp instrument wound, postoperative wound healing, the pharmaceutical composition of suppression cicatrix and the system thereof such as lancinate
Preparation Method.
Background technology
The wounds such as sharp instrument wound, surgical incision such as lancinate belong to the tissue injurys such as skin, and general process and treatment are tight
The anxious wound site that processes, or postoperative immediately treat operative incision, then wait the automatic healing due to body recovery power.But,
This kind of self-recovery needs the long period to can be only achieved rehabilitation, and pain continues, more importantly need active prevention wound/
Infection of incisional wound.Accordingly, it would be desirable to wound site imposes medicine etc., active prevention infects, promotes wound healing.In wound
Normal repair process in, necessarily cause mode of appearance and the tissue pathologies change of normal skin tissue, i.e. form cicatrix.Scar
Trace is the inevitable product in human body processes of wound repair, does not has scar tissue the most just not have the healing of wound.But, cicatrix is raw
Length exceedes certain limit, and various complication will occur, and the destruction of such as profile and functional activity obstacle etc. bring to patient
The huge human body is painful and psychic pain, caused by the incisional wound that the most serious wound or major surgery cause
With the cicatrix left over.
At present, the medicine work mainly use the such as cell migration promoting or stimulating participation wound healing clinically, breaking up and breeding
For trauma care medicine, the aseptic process of wound to be kept a close eye on.And for the process of cicatrix, presently mainly smear steroid
Body parahormone medicine, or to cicatrization position, the biggest keloid forming part injection steroid hormonal drugs.
But, the former does not has the most definite curative effect, although the latter has certain curative effect, however it is necessary that duplicate injection tens of times, from
And patient compliance is poor, and bringing great pain to patient, therefore, existing clinical treatment can not meet the clinical and need of patient
Want.
If there being a kind of medicine, it easily can be used by patient's simply smearing voluntarily；There is strong antibacterial activity,
Prevention traumatic infection；There is strong promotion wound healing effect, accelerate wound healing；There is again the synulotic work of strong suppression simultaneously
With, especially reducing the formation of big cicatrix or keloid, this medicine will have far-reaching clinical meaning and wide
Market prospect.
Oxytetracycline is tetracycline antibiotics, for broad-spectrum antibacterial agent, was once widely used in tularemia, the plague, cholera, typhoid fever, returns
Return heat, chancroid, urethritis, trachoma, scrub typhus, epidemic typhus, endemic typhus, sexually transmitted disease (STD), cervicitis,
The treatment of the diseases such as Q heat, typhus fever, psittacosis, but owing to current common pathogen is serious, clinically to oxytetracycline drug resistance
This medicine of the most less use.
Summary of the invention
It is an object of the invention to provide a kind of promotion wound healing and effectively suppress synulotic compositions and preparation method thereof.
The present invention is to sum up to find in the medical practice up to more than 40 years: oxytetracycline has and significantly promotes sharp instruments such as lancinating
The healing of wound, postoperative wound, suppression cicatrization, can also effectively prevent the effect of traumatic infection simultaneously, and further combined with in vain
Sugar and Oleum sesami are the ointment that preparation of raw material goes out that method is easy.
The most not yet have been reported that the external used medicine used containing active component oxytetracycline or its pharmaceutically acceptable salt lancinates for promotion
Etc. sharp instrument wound, postoperative wound healing, suppress synulotic treatment, and be not the most disclosed active component oxytetracycline or its
The external used medicine of pharmaceutically acceptable salt for promotion lancinate etc. sharp instrument wound, postoperative wound healing, suppress synulotic treatment
Compositions and preparation method thereof.
The concrete technical scheme of the present invention: the pharmaceutical composition of the present invention, its feature includes oxytetracycline or it is pharmaceutically acceptable
Salt, white sugar, Oleum Glycines, be made up of following weight proportion: oxytetracycline or its pharmaceutically acceptable salt 1 part, white sugar 2～3 parts,
Oleum Glycines 3～5 parts.
Optimum weight part proportioning of above-mentioned pharmaceutical composition is: oxytetracycline or its pharmaceutically acceptable salt 1 part, white sugar 2 parts,
3 parts of Oleum Glycines.
The preparation method of the present invention comprises the following steps:
(1) oxytetracycline or its pharmaceutically acceptable salt are pulverized, fully pulverize, cross 100 mesh sieves；
(2) white sugar pulverizes, and fully pulverizes, and crosses 100 mesh sieves；
(3) oxytetracycline, white sugar and the Oleum Glycines after above-mentioned pulverizing and sieving is weighed by weight ratio, by oxytetracycline and white sugar bean
Oil stirs；
(4) 121 DEG C of moist heat sterilizations of the pharmaceutical composition after stirring 30 minutes, then sterile filling is in aseptic process
Brown Glass Brown glass bottles and jars only in i.e. obtain pharmaceutical composition finally.
Advantages of the present invention: use above-mentioned formula, has prevention and infects, reduces pain injury from sharp utensil, the postoperative wound etc. such as lancinate,
Significantly press down the cicatrix processed during wound healing to generate simultaneously.
Detailed description of the invention
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
Weigh oxytetracycline 10g respectively, fully pulverize, cross 100 mesh sieves；Weigh white sugar 20g to pulverize, fully pulverize, cross 100 mesh
Sieve；Weigh Oleum Glycines 30g, add the oxytetracycline after pulverizing and sieving and white sugar, fully mix uniformly；Medicine group after stirring
121 DEG C of moist heat sterilizations of compound 30 minutes；The Brown Glass Brown glass bottles and jars only of 10ml loading amount is cleaned rear 121 DEG C of moist heat sterilizations 30 minutes；?
In aseptic operating platform, the pharmaceutical composition fill after mixing sterilizing is i.e. obtained the present invention in the Brown Glass Brown glass bottles and jars only of aseptic process
Pharmaceutical composition.
Embodiment 2
Weigh tetramycin hydrochloride 10.79g (10g in terms of oxytetracycline) respectively, fully pulverize, cross 100 mesh sieves；Weigh white sugar 20g
Pulverize, fully pulverize, cross 100 mesh sieves；Weigh Oleum Glycines 30g, add the oxytetracycline after pulverizing and sieving and white sugar, fully mix all
Even；121 DEG C of moist heat sterilizations of pharmaceutical composition after stirring 30 minutes；After the Brown Glass Brown glass bottles and jars only of 10ml loading amount is cleaned
121 DEG C of moist heat sterilizations 30 minutes；In aseptic operating platform, by the pharmaceutical composition fill after mixing sterilizing in aseptic process
Brown Glass Brown glass bottles and jars only in i.e. obtain the pharmaceutical composition of the present invention.
Embodiment 3
Weigh oxytetracycline 10g respectively, fully pulverize, cross 100 mesh sieves；Weigh white sugar 30g to pulverize, fully pulverize, cross 100 mesh
Sieve；Weigh Oleum Glycines 30g, add the oxytetracycline after pulverizing and sieving and white sugar, fully mix uniformly；Medicine group after stirring
121 DEG C of moist heat sterilizations of compound 30 minutes；The Brown Glass Brown glass bottles and jars only of 10ml loading amount is cleaned rear 121 DEG C of moist heat sterilizations 30 minutes；?
In aseptic operating platform, the pharmaceutical composition fill after mixing sterilizing is i.e. obtained the present invention in the Brown Glass Brown glass bottles and jars only of aseptic process
Pharmaceutical composition.
Embodiment 4
Weigh oxytetracycline 10g respectively, fully pulverize, cross 100 mesh sieves；Weigh white sugar 30g to pulverize, fully pulverize, cross 100 mesh
Sieve；Weigh Oleum Glycines 50g, add the oxytetracycline after pulverizing and sieving and white sugar, fully mix uniformly；Medicine group after stirring
121 DEG C of moist heat sterilizations of compound 30 minutes；The Brown Glass Brown glass bottles and jars only of 10ml loading amount is cleaned rear 121 DEG C of moist heat sterilizations 30 minutes；?
In aseptic operating platform, the pharmaceutical composition fill after mixing sterilizing is i.e. obtained the present invention in the Brown Glass Brown glass bottles and jars only of aseptic process
Pharmaceutical composition.
Embodiment 5
Weigh oxytetracycline 10g respectively, fully pulverize, cross 100 mesh sieves；Weigh white sugar 20g to pulverize, fully pulverize, cross 100 mesh
Sieve；Weigh Oleum Glycines 50g, add the oxytetracycline after pulverizing and sieving and white sugar, fully mix uniformly；Medicine group after stirring
121 DEG C of moist heat sterilizations of compound 30 minutes；The Brown Glass Brown glass bottles and jars only of 10ml loading amount is cleaned rear 121 DEG C of moist heat sterilizations 30 minutes；?
In aseptic operating platform, the pharmaceutical composition fill after mixing sterilizing is i.e. obtained the present invention in the Brown Glass Brown glass bottles and jars only of aseptic process
Pharmaceutical composition.
Application Example 1
Liu, man, 45 years old, Han nationality, firmly interwined dragon village village, Ao Shan Wei Town, Shandong Jimo City.In June, 2010 is because using electric planer improper
Cause left hand palm of the hand muscle tear wound, the wounded's wound saline is cleaned, after processing with iodine tincture, be coated with the basis spreading embodiment 1 preparation
Invention pharmaceutical composition, changes dressings once in 1 day, within after 1 week 2 days, changes dressings once, uses pharmaceutical composition of the present invention after 15 days,
The otch of the wounded heals completely.
Application Example 2
Wang, man, 52 years old, Han nationality, firmly Liu Li village, indigo plant villages and small towns, Shandong Jimo City.In October, 2012 is because of getting wheat accident cutter
Wound is to arm back, and otch is up to 13cm, and otch bosom reaches 1cm, is cleaned by the wounded's wound saline, after processing with iodine tincture,
It is coated with the pharmaceutical composition of the present invention spreading embodiment 1 preparation, within 2 days, changes dressings once, use pharmaceutical composition of the present invention after 15 days,
The otch of the wounded heals completely, and incision does not has cicatrix substantially, and skin elasticity is normal, and soft surface is ruddy, without symptoms such as prurituss.
It is the most satisfied that wound healing is repaired result by the wounded.
Application Example 3
Zhao, female, 50 years old, Han nationality, firmly the west village, Duan Bolan town, Shandong Jimo City.In April, 2015 causes left foot instep because of traffic accident
Injured postoperative infection suppurates, and the wounded's wound saline is cleaned by wound area 4cmX4.5cm, after processing with iodine tincture, is coated with and spreads enforcement
The pharmaceutical composition of the present invention of example 1 preparation, changes dressings once in 2 days, and after 20 days, heal completely in the wound of the wounded.
Claims (3)
1. one kind promotes wound healing and effectively suppresses synulotic compositions, it is characterised in that described compositions is by oxytetracycline or its medicine
Acceptable salt on, white sugar, Oleum Glycines composition, its weight proportion is: oxytetracycline or its pharmaceutically acceptable salt 1 part,
White sugar 2～3 parts, Oleum Glycines 3～5 parts.
2. compositions as claimed in claim 1, it is characterised in that be made up of the raw material of following weight proportioning: oxytetracycline or its pharmaceutically
Acceptable salt 1 part, white sugar 2 parts, 3 parts of Oleum Glycines.
3. the preparation method of a compositions as claimed in claim 1 or 2, it is characterised in that comprise the following steps: (1) is by oxytetracycline
Or its pharmaceutically acceptable salt pulverizes, fully pulverize, cross 100 mesh sieves；(2) white sugar pulverizes, and fully pulverizes, and crosses 100
Mesh sieve；(3) oxytetracycline, white sugar and the Oleum Glycines after above-mentioned pulverizing and sieving is weighed by weight ratio, by oxytetracycline and white sugar
Stir with Oleum Glycines；(4) 121 DEG C of moist heat sterilizations of the pharmaceutical composition after stirring 30 minutes, the most aseptic filling
It is loaded in the Brown Glass Brown glass bottles and jars only of aseptic process the pharmaceutical composition i.e. obtained finally.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610168882.1A CN105832655A (en) | 2016-03-15 | 2016-03-15 | Composition for promoting wound healing and effectively inhibiting scar formation and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610168882.1A CN105832655A (en) | 2016-03-15 | 2016-03-15 | Composition for promoting wound healing and effectively inhibiting scar formation and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105832655A true CN105832655A (en) | 2016-08-10 |
Family
ID=56582947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610168882.1A Pending CN105832655A (en) | 2016-03-15 | 2016-03-15 | Composition for promoting wound healing and effectively inhibiting scar formation and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105832655A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562140A (en) * | 2004-04-14 | 2005-01-12 | 李训峰 | Chinese-western combined medicine for treating burn and scald and other external wound |
| CN1686548A (en) * | 2005-05-08 | 2005-10-26 | 纪辉 | Ulcer quieting medicine its preparation and use |
| CN1695661A (en) * | 2004-08-31 | 2005-11-16 | 黄庙春 | Powder for treating burn |
| CN104107376A (en) * | 2014-08-14 | 2014-10-22 | 熊振铭 | Composition and preparation method of external anti-inflammatory drug |
-
2016
- 2016-03-15 CN CN201610168882.1A patent/CN105832655A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562140A (en) * | 2004-04-14 | 2005-01-12 | 李训峰 | Chinese-western combined medicine for treating burn and scald and other external wound |
| CN1695661A (en) * | 2004-08-31 | 2005-11-16 | 黄庙春 | Powder for treating burn |
| CN1686548A (en) * | 2005-05-08 | 2005-10-26 | 纪辉 | Ulcer quieting medicine its preparation and use |
| CN104107376A (en) * | 2014-08-14 | 2014-10-22 | 熊振铭 | Composition and preparation method of external anti-inflammatory drug |
Non-Patent Citations (2)
| Title |
|---|
| 张纪源: "《家庭食品安全使用手册》", 31 March 2009, 世界图书出版西安公司 * |
| 猎鹰: "《特种兵教你户外生存：中国户外生存手册》", 31 December 2012, 东方出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102579702B (en) | Medicine for treating dental ulcer and preparation method thereof | |
| CN103301501B (en) | Medical liquid dressing and preparation method thereof | |
| JP2019517533A (en) | External pharmaceutical composition for treatment of various wound wounds of skin and preparation method thereof | |
| CN103182070B (en) | External composition, and preparation and application thereof | |
| CN101703757B (en) | Plaster for reuniting fractured tendons and bones and activating blood, and preparation method thereof | |
| CN101352505B (en) | Bone fracture setting medicine powder for treating traumatic injury | |
| CN100502953C (en) | Wound surface active repairing material | |
| CN102293738A (en) | External preparation for and method treating arthritis | |
| CN105832655A (en) | Composition for promoting wound healing and effectively inhibiting scar formation and application thereof | |
| CN109674743B (en) | Wound care gel and preparation method thereof | |
| CN103191163B (en) | Skin wound repairing pharmaceutical composition | |
| WO2000078324A1 (en) | The leaves of cajanus cajan(l.) millsp and extract, formulation and uses thereof | |
| CN100531781C (en) | Chinese medicine composition for removing wart nevus | |
| CN102949712A (en) | Chinese and western composite medicine for treating neoplastic diseases | |
| CN102302603A (en) | External medicament for treating traumatic injury | |
| CN101653622A (en) | Amorphous aquagel pharmaceutic dressing of ShuangHuangLian and preparation method thereof | |
| Kumar et al. | Potential of Cissus qudrangularis transdermal patch for fracture healing | |
| CN104758310B (en) | Compound montmorillonite sucrose ointment and its preparation method and application | |
| CN1241629C (en) | External use medicine for treating AIDS virus | |
| RU2414909C2 (en) | Medication "regenerin" for local treatment of purulent diseases of soft tissues and method of its obtaining | |
| CN101322764A (en) | External use medicament for treating hyperosteogeny of cervical vertebra and lumbar principally and preparation thereof | |
| CN105168632A (en) | Traditional Chinese medicinal plastics for promoting healing of wound of cesarean section and preparation method thereof | |
| CN115634253A (en) | Medicine for promoting blood circulation to remove blood stasis and treating traumatic injury and shoulder, neck, waist and leg pain and preparation method thereof | |
| CN1139397C (en) | Plaster for treating hyperosteogeny and arthrosis | |
| CN103816181A (en) | Externally-applied Chinese and western medicine ointment capable of treating herpes zoster and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160810 |
|
| RJ01 | Rejection of invention patent application after publication |