CN101653622A - Amorphous aquagel pharmaceutic dressing of ShuangHuangLian and preparation method thereof - Google Patents
Amorphous aquagel pharmaceutic dressing of ShuangHuangLian and preparation method thereof Download PDFInfo
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- CN101653622A CN101653622A CN200910306915A CN200910306915A CN101653622A CN 101653622 A CN101653622 A CN 101653622A CN 200910306915 A CN200910306915 A CN 200910306915A CN 200910306915 A CN200910306915 A CN 200910306915A CN 101653622 A CN101653622 A CN 101653622A
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Abstract
The invention discloses an amorphous aquagel pharmaceutic dressing of ShuangHuangLian and a preparation method thereof. The dressing comprises the following raw materials in percentage by weight: 0.1-20 ShuangHuangLian extractives, 2-40 aquagel substrate and 40-97.9 water. The preparation method of the dressing comprises the following steps: firstly, dissolving a certain amount of ShuangHuangLianextractives into water occupying one third of a corresponding total amount to prepare a ShuangHuangLian extractive aqueous solution; adding the aquagel substrate to water occupying one third of a corresponding total amount to stir to form adhesive cement; adding the ShuangHuangLian extractive aqueous solution and the rest water to the adhesive cement while stirring; uniformly stirring; degassing in vacuum to obtain the amorphous aquagel pharmaceutic dressing of ShuangHuangLian. The amorphous aquagel pharmaceutic dressing of ShuangHuangLian is filled in the disease site of a patient, has accurate healing efficacy of resisting infection, stimulating wound healing, and the like, has no toxicity, excitability, irritability or peeling reaction to human beings, is safe and reliable and has obvious social and economic benefits.
Description
Technical field
The invention belongs to the medical dressing technical field, be specifically related to a kind of amorphous aquagel pharmaceutic dressing of ShuangHuangLian, the invention still further relates to the preparation method of this medical dressing.
Background technology
SHUANGHUANLIAN is from the extract that extracts of Chinese medicine Flos Lonicerae, Radix Scutellariae, the Fructus Forsythiae of extensive use clinically, its preparation has injection, powder pin, oral liquid, granule etc., have functions such as antibacterial anti-inflammatory, antiviral, but do not see at present the SHUANGHUANLIAN extract is prepared into medical dressing.
Summary of the invention
The purpose of this invention is to provide a kind of amorphous aquagel pharmaceutic dressing of ShuangHuangLian, principal agent SHUANGHUANLIAN extract is scattered in makes medical dressing in the substrate, when this medical dressing was affixed on the patient affected part, SHUANGHUANLIAN extract slow-release volatilization antibacterial action reached the purpose of treatment.
Another object of the present invention provides the preparation method of above-mentioned dressing.
The technical solution adopted in the present invention is, a kind of amorphous aquagel pharmaceutic dressing of ShuangHuangLian, composed of the following components by mass percentage: SHUANGHUANLIAN extract: 0.1%～20%, hydrogel matrix: 2%～40%, water: 40%～97.9%, more than the mass percent summation of each component be 100%.
Another technical scheme of the present invention is, a kind of method for preparing amorphous aquagel pharmaceutic dressing of ShuangHuangLian, specifically implement: get 0.1%～20% SHUANGHUANLIAN extract respectively according to mass percent according to following steps, 2%～40% hydrogel matrix and 40%～97.9% water, get the SHUANGHUANLIAN extract of being got be dissolved in the above-mentioned total amount of fetching water 1/3 in make the SHUANGHUANLIAN solution of extract, again the hydrogel matrix of being got is joined the above-mentioned total amount of fetching water 1/3 in stir into rubber cement, under agitation SHUANGHUANLIAN solution of extract and remaining water are joined in the rubber cement, after stirring, vacuum outgas promptly obtains amorphous aquagel pharmaceutic dressing of ShuangHuangLian.
Characteristics of the present invention also are, hydrogel matrix is wherein selected one or more the mixture in gelatin, pectin, agaropectin, CMC, calcium alginate or the propylene glycol for use.
The invention has the beneficial effects as follows, this amorphous aquagel pharmaceutic dressing of ShuangHuangLian filling is infected in patient's surgical postoperative, trauma infection contamination, burn, scald infection, cellulitis, suppuration L inflammation, chronic ulcer, decubital ulcer, pressure ulcer, facial acne, impetigo, wound disunion of a specified duration, folliculitis, chickenpox, verruca vulgaris, flat skin wart, herpes simplex, erosive eczema, disease locations such as neurodermatitis, infection, promote determined curative effects such as wound healing, nontoxic to human body, nonirritant, no anaphylaxis, do not have and peel off reaction, be safe and reliable medical dressing, have tangible economic benefit.
The specific embodiment
The present invention is described in detail below in conjunction with specific embodiment.
Amorphous aquagel pharmaceutic dressing of ShuangHuangLian of the present invention, composed of the following components by mass percentage:
The SHUANGHUANLIAN extract: 0.1%～20%, hydrogel matrix: 2%～40%, water: 40%～97.9%, more than the mass percent summation of each component be 100%.Hydrogel matrix is wherein selected one or more the mixture in gelatin, pectin, agaropectin, CMC, calcium alginate, the propylene glycol for use.
The present invention prepares the method for amorphous aquagel pharmaceutic dressing of ShuangHuangLian, specifically implement: get 0.1%～20% SHUANGHUANLIAN extract respectively according to mass percent according to following steps, 2%～40% hydrogel matrix and 40%～97.9% water, get the SHUANGHUANLIAN extract of being got be dissolved in the above-mentioned total amount of fetching water 1/3 in make the SHUANGHUANLIAN solution of extract, again the hydrogel matrix of being got is joined the above-mentioned total amount of fetching water 1/3 in stir into rubber cement, under agitation SHUANGHUANLIAN solution of extract and remaining water are joined in the rubber cement, after stirring, vacuum outgas promptly obtains amorphous aquagel pharmaceutic dressing of ShuangHuangLian.
Medical record one:
Lee *, the man, 37 years old, because of cervical region plays pus point companion causalgia first quarter moon, to seek medical advice in many ways, effect is not good enough, comes to go to a doctor upon somebody's introduction.Examine and see that the cervical region side that takes over has the chronic wettability lump that covers, color is purplish red, and sees that a plurality of pus points are arranged on it, and pus is discharged by a plurality of hair follicles hole, forms cellular pus head, and that touches has a burning sensation; Whole body health check-up no abnormality seen; The lab testing routine blood test shows all in range of normal value.Diagnosis: carbuncle.Give the amorphous aquagel pharmaceutic dressing of ShuangHuangLian external application after 5 days, the pus head disappears, and redness also disappears, and continuous use is after 3 days, and skin lesion disappears.Do not give oral antibiotic during the treatment, follow up a case by regular visits to after January and do not see recurrence.
Medical record two:
Amorphous aquagel pharmaceutic dressing of ShuangHuangLian treatment decubital ulcer 10 examples.Man's 6 examples, women 4 examples.48～91 years old age, outpatient's 2 examples, inpatient's 8 examples.Hemiplegic patient 6 examples wherein, paraplegia 1 example, Fracture of femur 3 examples; Decubital ulcer forms the position: hipbone teat 2 examples, and sacrococcygeal region 3 examples, sacrococcygeal region adds hipbone portion 3 examples, ankle 1 example.By stages: the second stage of 2 examples, three phases 6 examples, the fourth phases 2 example.Area is 4cm*3cm～10cm*10cm.Therapeutic Method: the slough of removing the decubital ulcer surface earlier with the disinfectant surgical scissors, reuse saline cotton balls is wiped clean the secretions of skin ulcer face, at last with the disinfectant solution and the transudate of dry cotton ball exhaustion skin ulcer face, make skin ulcer face drying, according to skin ulcer face size external application amorphous aquagel pharmaceutic dressing of ShuangHuangLian, 1 time/day, till healing.Three, the sweet-scented osmanthus skin ulcer gives anti-inflammatory treatment simultaneously the fourth phase.Therapeutic outcome: 1. produce effects: the skin ulcer face oozes out minimizing, and incrustation forms, the healing of 1～2 week, this group produce effects 6 examples; 2. effective: the skin ulcer reduction of area is little, oozes out minimizing, but the skin ulcer face fails to heal fully, and this organizes effective 3 examples; 3. invalid: the skin ulcer face oozes out and increases, and does not have incrustation, does not prolongedly heal, and this organizes invalid 1 example.The course of treatment is the shortest 3 days, and is the longest 14 days, and average 8.5 days, total effective rate 90%.
Embodiment 1
Get 0.1% SHUANGHUANLIAN extract, 2% gelatin and 97.9% water respectively according to mass percent, get the SHUANGHUANLIAN extract of being got be dissolved in the above-mentioned total amount of fetching water 1/3 in make the SHUANGHUANLIAN solution of extract, again the gelatin of being got is joined the above-mentioned total amount of fetching water 1/3 in stir into rubber cement, under agitation SHUANGHUANLIAN solution of extract and remaining water are joined in the rubber cement, after stirring, vacuum outgas promptly obtains amorphous aquagel pharmaceutic dressing of ShuangHuangLian.
Embodiment 2
Get 20% SHUANGHUANLIAN extract, 40% pectin and 40% water respectively according to mass percent, get the SHUANGHUANLIAN extract of being got be dissolved in the above-mentioned total amount of fetching water 1/3 in make the SHUANGHUANLIAN solution of extract, again the pectin of being got is joined the above-mentioned total amount of fetching water 1/3 in stir into rubber cement, under agitation SHUANGHUANLIAN solution of extract and remaining water are joined in the rubber cement, after stirring, vacuum outgas promptly obtains amorphous aquagel pharmaceutic dressing of ShuangHuangLian.
Embodiment 3
Get 10% SHUANGHUANLIAN extract, 30% agaropectin and the mixture of propylene glycol and 60% water respectively according to mass percent, get the SHUANGHUANLIAN extract of being got be dissolved in the above-mentioned total amount of fetching water 1/3 in make the SHUANGHUANLIAN solution of extract, again the mixture of the agaropectin got and propylene glycol is joined the above-mentioned total amount of fetching water 1/3 in stir into rubber cement, under agitation SHUANGHUANLIAN solution of extract and remaining water are joined in the rubber cement, after stirring, vacuum outgas promptly obtains amorphous aquagel pharmaceutic dressing of ShuangHuangLian.
Embodiment 4
Get 8% SHUANGHUANLIAN extract, 15% CMC and the mixture of calcium alginate and 77% water respectively according to mass percent, get the SHUANGHUANLIAN extract of being got be dissolved in the above-mentioned total amount of fetching water 1/3 in make the SHUANGHUANLIAN solution of extract, again the mixture of the CMC that got and calcium alginate is joined the above-mentioned total amount of fetching water 1/3 in stir into rubber cement, under agitation SHUANGHUANLIAN solution of extract and remaining water are joined in the rubber cement, after stirring, vacuum outgas promptly obtains amorphous aquagel pharmaceutic dressing of ShuangHuangLian.
Amorphous aquagel pharmaceutic dressing of ShuangHuangLian filling of the present invention is in the disease of patient position, infection, promote determined curative effect such as wound healing,, nonirritant nontoxic to human body, no anaphylaxis do not have and peel off reaction, be safe and reliable medical dressing, have obvious social and economic benefits.
Claims (4)
1. amorphous aquagel pharmaceutic dressing of ShuangHuangLian, it is characterized in that, composed of the following components by mass percentage: the SHUANGHUANLIAN extract: 0.1%～20%, hydrogel matrix: 2%～40%, water: 40%～97.9%, more than the mass percent summation of each component be 100%.
2. according to the described amorphous aquagel pharmaceutic dressing of ShuangHuangLian of claim 1, it is characterized in that described hydrogel matrix is selected one or more the mixture in gelatin, pectin, agaropectin, CMC, calcium alginate or the propylene glycol for use.
3. method for preparing the described amorphous aquagel pharmaceutic dressing of ShuangHuangLian of claim 1, it is characterized in that, specifically implement: get 0.1%～20% SHUANGHUANLIAN extract respectively according to mass percent according to following steps, 2%～40% hydrogel matrix and 40%～97.9% water, get the SHUANGHUANLIAN extract of being got be dissolved in the above-mentioned total amount of fetching water 1/3 in make the SHUANGHUANLIAN solution of extract, again the hydrogel matrix of being got is joined the above-mentioned total amount of fetching water 1/3 in stir into rubber cement, under agitation SHUANGHUANLIAN solution of extract and remaining water are joined in the rubber cement, after stirring, vacuum outgas promptly obtains amorphous aquagel pharmaceutic dressing of ShuangHuangLian.
4. according to the preparation method of the described amorphous aquagel pharmaceutic dressing of ShuangHuangLian of claim 3, it is characterized in that described hydrogel matrix is selected one or more the mixture in gelatin, pectin, agaropectin, CMC, calcium alginate or the propylene glycol for use.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910306915A CN101653622A (en) | 2009-09-11 | 2009-09-11 | Amorphous aquagel pharmaceutic dressing of ShuangHuangLian and preparation method thereof |
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| CN200910306915A CN101653622A (en) | 2009-09-11 | 2009-09-11 | Amorphous aquagel pharmaceutic dressing of ShuangHuangLian and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104841008A (en) * | 2015-06-11 | 2015-08-19 | 傅兴琴 | Hydrogel dressing and preparation method thereof |
| CN105031709A (en) * | 2015-08-28 | 2015-11-11 | 重庆医科大学附属永川医院 | Medical hydrocolloid dressing and preparation method |
| CN110665052A (en) * | 2019-10-24 | 2020-01-10 | 上饶师范学院 | Puerarin hydrogel wound auxiliary material |
-
2009
- 2009-09-11 CN CN200910306915A patent/CN101653622A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104841008A (en) * | 2015-06-11 | 2015-08-19 | 傅兴琴 | Hydrogel dressing and preparation method thereof |
| CN105031709A (en) * | 2015-08-28 | 2015-11-11 | 重庆医科大学附属永川医院 | Medical hydrocolloid dressing and preparation method |
| CN105031709B (en) * | 2015-08-28 | 2017-12-15 | 重庆医科大学附属永川医院 | A kind of preparation method of medical use hydrocolloid dressing |
| CN110665052A (en) * | 2019-10-24 | 2020-01-10 | 上饶师范学院 | Puerarin hydrogel wound auxiliary material |
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Application publication date: 20100224 |