CN1058184C - Gynaecologist's hemostatic - Google Patents
Gynaecologist's hemostatic Download PDFInfo
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- CN1058184C CN1058184C CN97125738A CN97125738A CN1058184C CN 1058184 C CN1058184 C CN 1058184C CN 97125738 A CN97125738 A CN 97125738A CN 97125738 A CN97125738 A CN 97125738A CN 1058184 C CN1058184 C CN 1058184C
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Abstract
The present invention discloses a medical composition for curing postabortal hemorrhage, which is composed of notoginseng, cuttlebone, madder, arnebia root, rehmannia root and garden burnet root. The present invention can be used for preventing and curing overlong time of medical postabortal colporrhagia, irregular hemorrhage caused by intrauterine devices or menostaxis and metropathia hemorrhagica.
Description
The present invention is a kind of gynecological's hemostatic medicine that is used for, and this medicine is an effective ingredient with Chinese medicine, makes medicament, is used for the treatment of the vaginal hemorrhage that drug induced abortion, artificial abortion, intrauterine contraceptive device in utero, subcutaneous implantation contraception etc. cause.Belong to drug world.
The effect of mifepristone combined with misoprostol antiearly pregnancy is very sure, and it is clinical to be widely used in family planning.Because the medicine termination of early pregnancy has been avoided uteroventral operation, the patient suffering reduces, and post-operative complication is also reduced, thereby be subjected to the women of child-bearing age's popular welcome.But hemorrhage after drug abortion overlong time (the average bleeding time reached for 2～3 weeks), amount of bleeding is many, becomes problem that needs to be resolved hurrily and acquire a certain degree of difficulty in the drug induced abortion.Conclude and study situation in recent years, Western medicine has Methyl testosterone, danazol etc.Even no matter Methyl testosterone is to the influence to hepatic and renal function of the influence of women of child-bearing age's endocrine function and danazol, with regard to effect, be not satisfactory yet, taking 7 days Methyl testosterone bleeding times accounts for 40.79%, accounted for 56.58% in 8～14 days, amount of bleeding＜100ml accounts for 76.31%, 100～150ml and accounts for 19.73%.And danazol can improve the artificial abortion rate, but the bleeding time is not had obvious change.Chinese medicine has Radix Arnebiae (Radix Lithospermi), SHENGHUATANG, peace palace electuary, YUNNAN BAIYAO etc., because its case history choice criteria is different with observation index, curative effect differs greatly, and the bleeding time was not waited at 7～17 days.At present, this aspect research is only limited to clinical observation, lacks the basic research of strict system.
The hemorrhage after drug abortion overlong time, amount of bleeding reaches the genital system infection that may bring out thus more, influences patient's health, life and work, hinders the further popularization of medicine termination of early pregnancy, even has influence on the fertility state basic policy that realizes a plan to a certain extent.Therefore, it is imperative to try to explore to study its effectively preventing method.
The object of the invention provides a kind of cooperation medicine termination of early pregnancy, can shorten the bleeding time, reduce the Chinese medicine preparation of amount of bleeding.
Though hemorrhage after drug abortion not corresponding record in TCM Document incessantly, decidua and foetal sac necrosis are peeled off and are caused in the born of the same parents blood vessels impaired when flow according to medicine, are detained blood circulating out of vessels, genus postpartum lochiorrhea category.Dialectical few for a long time during according to the patient's bleeding amount, or dripping urine endlessly, color is purplish red, accompanies clot, or increases suddenly, and the red matter of color is thick, and with sagging distention in the smaller abdomen, body of the tongue is red partially, and slippery and rapid pulse or stringy and rapid pulse surely belong to retention of heat in the interior.Consider that the patient is young women, healthy and strong, in the green, the course of disease is shorter in addition, amount of bleeding is lacked than childbirth, pathogenesis is when excess syndrome relatively, but drug induced abortion " is adopted broken its shell; disconnected its root " and must be damaged body healthy energy as giving birth to, this age bracket women consciousness of striving unexpectedly is strong in addition, and the psychosoma burden is heavy, often stays body and keeps healthy in ignoring.The anxiety of hiding deficiency syndrome in the historical facts or anecdotes card.This thinks with modern medicine that the more than main cause of hemorrhage after drug abortion is that fine hair, decidua are residual, uterine contraction is weak and secondary intrauterine infection etc. is to be consistent." stagnant blood does not go the difficult peace of then good blood, also descends mutually, and is with the passing of time more than.It is main that blood circulation promoting and blood stasis dispelling, cooling blood for hemostasis are answered in treatment, holds concurrently with yin nourishing.Medicine of the present invention is followed this Therapeutic Principle just, in abundant screening, produces on the basis of repeated multiple times clinical practice.
Pharmaceutical preparation of the present invention is to be the preparation that raw material is made with following pharmaceutical composition:
Radix Notoginseng 3-10 weight portion
Os Sepiae 8-15 weight portion
Radix Rubiae 8-15 weight portion
Radix Arnebiae (Radix Lithospermi) 8-15 weight portion
Radix Rehmanniae 15-25 weight portion
Radix Sanguisorbae 8-15 weight portion
In the middle of the pharmaceutical composition of the present invention, the Radix Notoginseng removing stasis to stop bleeding, the analgesic therapy of invigorating blood circulation is a monarch drug; Os Sepiae, Radix Rubiae, Radix Sanguisorbae removing heat from blood and promoting blood circulation, astringing to arrest bleeding are ministerial drug; The Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi) clearing away heat and nourishing YIN, removing pathogenic heat from blood and toxic substance from the body are adjuvant drug.All medicines share, and blood stasis dispelling is not just being hindered, and the stasis of blood is not stayed in hemostasis.According to modern pharmacological research, compositions such as the contained Saponin of medicine of the present invention, calcium ion have the uterine contraction of reinforcement, shorten effects such as clotting time, hemostasis, antiinflammatory.
Aforementioned pharmaceutical compositions of the present invention is the active constituents of medicine of preparation medicine of the present invention, said composition is when being prepared into medicament, also can add conventional medicine excipient, for example, solvent, binding agent, filler, disintegrating agent, antiseptic, correctives, solubilizing agent etc.
Aforementioned pharmaceutical compositions of the present invention according to the preparation process of routine, can be prepared into any pharmaceutical dosage form that is suitable for using clinically, for example, and electuary, tablet, oral liquid, capsule, unguentum, powder, pill, suspensoid etc.
The technology that pharmaceutical composition of the present invention is made electuary is:
Select raw medicinal material according to prescription component and consumption, decoct with water 2-3 time, decocted 0.5-1.5 hour at every turn, filter, merging filtrate is condensed into extractum, and drying is ground into fine powder, granulates, and gets electuary.
The indication of medicine of the present invention:
1, is used for vaginal bleeding after drug abortion.Its effect mainly is to shorten the bleeding time;
2, be used for intrauterine device and cause abnormal vaginal bleeding or menostaxis;
3, dysfunctional uterine hemorrhage.
Medicine of the present invention has good haemostatic effect, and haemostatic effect is fast, anastalsis is strong.Clinical observation 46 routine patients' PRELIMINARY RESULTS shows: the bleeding time basic controlling is (individual patient is because of the postoperative fatigue, and the bleeding time can reach 8～9 days) within 5-7 days.Amount of bleeding and menorrhea amount basic identical or many slightly (own control), the postoperative menstrual onset is normal.
The clinical research of experimental example medical treatment hemorrhage after drug abortion of the present invention
One, object of study:
1, screens object in strict accordance with the indication and the contraindication of mifepristone/prostaglandin antiearly pregnancy;
2, anti-early pregnancy drug mifepristone/misoprostol adopts the gradation instructions about how to take medicine, and each fasting is 2 hours before and after taking medicine at every turn:
3, take artificial abortion person behind mifepristone/misoprostol.
Two, clinical data:
This group is totally 98 examples, is the outpatient.Be divided into seminar, matched group at random.Seminar's 68 examples, matched group 30 examples, two groups at age, pregnant time, parity, pregnant natural law, B ultrasonic prompting peptide capsule size and usually aspect the menstrual blood loss, basically identical, feature P＞0.05 (t check) relatively between group.
Three, research method:
1, medication: each group is 1 hour oral medicine behind mifepristone/misoprostol artificial abortion all.The treatment group is taken medicine of the present invention, and matched group does not add uses any medicine.
2, observation index:
Bleeding time: the hemorrhage clean required natural law in Zhiyin road behind the artificial abortion.
Amount of bleeding: with self menstrual blood volume contrast usually.
3, criterion of therapeutical effect:
Produce effects: after taking mifepristone/misoprostol artificial abortion, the vagina continuous bleeding time is less than or equal to 7 days; Amount of bleeding is less than self menstrual blood volume or similar to it.
Effectively: after taking mifepristone/misoprostol artificial abortion, the vagina continuous bleeding time is greater than 7 days, less than 15 days; Amount of bleeding is similar to self menstrual blood volume or be less than 1.5 times of self menstrual blood volume.
Invalid: after taking mifepristone/misoprostol artificial abortion, the vagina continuous bleeding time was greater than 15 days; Or amount of bleeding is greater than 1.5 times of self menstrual blood volume.
The result:
| Total routine number | Produce effects (%) | Effectively (%) | Invalid (%) | Total effective rate | |
| Seminar | 68 | *48(70.6％) | 17(25％) | 3(4.4％) | #65(95.6％) |
| Matched group | 30 | 7(23.3％) | 16(53.3％) | 7(23.3％) | 23(76.6％) |
Annotate: * and matched group be P＜0.05 relatively, and difference has the significance meaning.
# and matched group be P＜0.05 relatively, and difference has the significance meaning.
Clinical research is the result show: seminar and matched group obvious effective rate and total effective rate all have significant difference (P＜0.05), illustrate that medicine of the present invention has effect preferably to the control hemorrhage after drug abortion.
Embodiment 1
Radix Notoginseng 6g
Os Sepiae 10g
Radix Rubiae 10g
Radix Arnebiae (Radix Lithospermi) 10g
Radix Rehmanniae 20g
Radix Sanguisorbae 10g
Method for making:
Select raw medicinal material according to prescription component and consumption, decoct with water 2 times, decocted 1 hour at every turn, filter, merging filtrate is condensed into extractum, and drying is ground into fine powder, granulates, and gets electuary.
Embodiment 2
Radix Notoginseng 3g
Os Sepiae 8g
Radix Rubiae 8g
Radix Arnebiae (Radix Lithospermi) 8g
Radix Rehmanniae 15g
Radix Sanguisorbae 8g
Above-mentioned medical material is added 3 times of amounts of water, decocted 1 hour, get medicinal liquid, medicinal residues add 2 times of amounts of water again, decoct 0.5 hour, merge medicinal liquid twice, filter, and are condensed into fluid extract, add amount of starch, and mixing is granulated, and tabletting makes tablet.
Claims (3)
1, a kind of hemorrhage pharmaceutical composition post-abortion for the treatment of is characterized in that this medicine made by following raw materials according: Radix Notoginseng 3-10 weight portion Os Sepiae 8-15 weight portion Radix Rubiae 8-15 weight portion Radix Arnebiae (Radix Lithospermi) 8-15 weight portion Radix Rehmanniae 15-25 weight portion Radix Sanguisorbae 8-15 weight portion.
2,, it is characterized in that this medicine made by following raw materials according: Radix Notoginseng 6g Os Sepiae 10g Radix Rubiae 10g Radix Arnebiae (Radix Lithospermi) 10g Radix Rehmanniae 20g Radix Sanguisorbae 10g according to the pharmaceutical composition of claim 1.
3,, it is characterized in that this medicine contains excipient according to the pharmaceutical composition of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97125738A CN1058184C (en) | 1997-12-30 | 1997-12-30 | Gynaecologist's hemostatic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97125738A CN1058184C (en) | 1997-12-30 | 1997-12-30 | Gynaecologist's hemostatic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1183987A CN1183987A (en) | 1998-06-10 |
| CN1058184C true CN1058184C (en) | 2000-11-08 |
Family
ID=5177378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97125738A Expired - Fee Related CN1058184C (en) | 1997-12-30 | 1997-12-30 | Gynaecologist's hemostatic |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1058184C (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100394936C (en) * | 2005-11-17 | 2008-06-18 | 西安千禾药业有限责任公司 | Medicine for treating flooding and spotting and its preparation method |
| CN101199655B (en) * | 2007-11-30 | 2012-01-25 | 薛晓彤 | Chinese medicine agent for treating after medicament abortion uterus bleeding |
| CN102961496A (en) * | 2012-12-02 | 2013-03-13 | 张娜 | Traditional Chinese medicine composition for treating sudden and violent menstrual blood |
| CN103055102B (en) * | 2012-12-16 | 2014-05-21 | 蒋仕珍 | Traditional Chinese medicine used for stopping bleeding, relieving pain and promoting tissue regeneration of wound |
| CN104225394A (en) * | 2014-06-04 | 2014-12-24 | 王霞 | Traditional Chinese medicine for treating postpartum gynecological diseases |
| CN104147181A (en) * | 2014-08-07 | 2014-11-19 | 四川金堂海纳生物医药技术研究所 | Powder medicine for treating posterior pituitary tumor and hemafecia and preparation method |
| CN105477413A (en) * | 2015-12-17 | 2016-04-13 | 王丽艳 | Compound medicine for treating vaginal bleeding caused by medical abortion |
| CN105497403A (en) * | 2016-01-31 | 2016-04-20 | 济南新时代医药科技有限公司 | Traditional Chinese medicine capable of treating long-time colporrhagia of patient after medical abortion |
-
1997
- 1997-12-30 CN CN97125738A patent/CN1058184C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 《中医杂志》1990,31(3) 1990.3.30 姚寓晨，益气清营固冲汤治疗妇科血证举隅 * |
| 《中国医药学报》1995,10(6) 1995.6.30 张琼芳等，清宫止血饮治疗药物及人工流产后出血68例的流产观察 * |
| 《中国医药学报》1995,10(6) 1995.6.30 张琼芳等，清宫止血饮治疗药物及人工流产后出血68例的流产观察;《中医杂志》1990,31(3) 1990.3.30 姚寓晨，益气清营固冲汤治疗妇科血证举隅 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1183987A (en) | 1998-06-10 |
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