CN105816867A - 预防乳腺癌复发的疫苗 - Google Patents
预防乳腺癌复发的疫苗 Download PDFInfo
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- CN105816867A CN105816867A CN201610201242.6A CN201610201242A CN105816867A CN 105816867 A CN105816867 A CN 105816867A CN 201610201242 A CN201610201242 A CN 201610201242A CN 105816867 A CN105816867 A CN 105816867A
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| US8945573B2 (en) | 2005-09-08 | 2015-02-03 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Targeted identification of immunogenic peptides |
| US8222214B2 (en) * | 2007-06-01 | 2012-07-17 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Vaccine for the prevention of breast cancer relapse |
| AU2009324707B2 (en) | 2008-12-10 | 2015-04-30 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Vaccine for the prevention of breast cancer recurrence |
| AU2013221309B2 (en) | 2012-02-17 | 2017-03-30 | Mayo Foundation For Medical Education And Research | Methods and materials for generating CD8+ T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide |
| US10028918B2 (en) | 2012-05-08 | 2018-07-24 | Albert Einstein College Of Medicine, Inc. | Nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine and uses thereof |
| US9175082B2 (en) | 2012-05-31 | 2015-11-03 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind PD-L1 |
| AR094403A1 (es) * | 2013-01-11 | 2015-07-29 | Hoffmann La Roche | Terapia de combinación de anticuerpos anti-her3 |
| EP2762161A1 (en) * | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | E75-vaccine composition for mucosal administration |
| US20140220100A1 (en) * | 2013-02-05 | 2014-08-07 | Nitto Denko Corporation | Vaccine composition for transdermal administration |
| EP2777711A1 (en) | 2013-03-11 | 2014-09-17 | Icon Genetics GmbH | Her2/Neu cancer vaccine |
| CN104513293A (zh) * | 2013-09-26 | 2015-04-15 | 深圳信立泰药业股份有限公司 | 一种多肽疫苗的盐及其制备方法和含有该盐的药物制品 |
| US20160258951A1 (en) * | 2013-10-28 | 2016-09-08 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods of monitoring immune responses |
| US10434152B2 (en) * | 2014-02-20 | 2019-10-08 | Wayne State University | HER2 antigenic polypeptide compositions, and methods for their use in treatment and prevention of carcinomas |
| BR112018015480A2 (pt) | 2016-01-29 | 2019-05-21 | Sorrento Therapeutics, Inc. | proteínas de ligação ao antígeno que se ligam a pd-l1 |
| EP3463438B1 (en) * | 2016-05-31 | 2022-04-06 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Vaccine therapy for treatment of endometrial and ovarian cancer |
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| CN117280219A (zh) | 2021-05-04 | 2023-12-22 | 阿斯顿科学公司 | Her2疫苗组合物 |
| KR20230017640A (ko) | 2021-07-28 | 2023-02-06 | 주식회사 애스톤사이언스 | Her2 백신 조성물 |
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Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4744984A (en) | 1985-10-08 | 1988-05-17 | Vetrepharm Research, Inc. | Antiviral immunotherapeutic agent and preparation thereof |
| ATE155813T1 (de) * | 1989-05-19 | 1997-08-15 | Genentech Inc | Her2 extrazellulare domäne |
| US7252829B1 (en) * | 1998-06-17 | 2007-08-07 | Idm Pharma, Inc. | HLA binding peptides and their uses |
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| US6514942B1 (en) * | 1995-03-14 | 2003-02-04 | The Board Of Regents, The University Of Texas System | Methods and compositions for stimulating T-lymphocytes |
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| US5891432A (en) * | 1997-07-29 | 1999-04-06 | The Immune Response Corporation | Membrane-bound cytokine compositions comprising GM=CSF and methods of modulating an immune response using same |
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| US6602510B1 (en) * | 2000-04-05 | 2003-08-05 | Epimmune Inc. | HLA class I A2 tumor associated antigen peptides and vaccine compositions |
| US20030224036A1 (en) * | 1999-12-13 | 2003-12-04 | Fikes John D | Hla class I a2 tumor associated antigen peptides and vaccine compositions |
| US7037501B2 (en) * | 2001-01-04 | 2006-05-02 | Regents Of The University Of Minnesota | Myostatin immnoconjugate |
| CA2452382A1 (en) * | 2001-07-10 | 2003-01-23 | Corixa Corporation | Compositions and methods for delivery of proteins and adjuvants encapsulated in microspheres |
| US20030049253A1 (en) * | 2001-08-08 | 2003-03-13 | Li Frank Q. | Polymeric conjugates for delivery of MHC-recognized epitopes via peptide vaccines |
| US8802618B2 (en) | 2002-03-08 | 2014-08-12 | Board Of Regents, The University Of Texas System | Controlled modulation of amino acid side chain length of peptide antigens |
| KR100555211B1 (ko) * | 2002-07-16 | 2006-03-03 | 주식회사 팬제노믹스 | 항암효과를 갖는 Ｈｅｒ-２/ｎｅｕ ＤＮＡ 백신 |
| US7223408B2 (en) * | 2002-10-03 | 2007-05-29 | Wyeth Holdings Corporation | Human papillomavirus polypeptides and immunogenic compositions |
| WO2004069866A1 (en) | 2003-02-10 | 2004-08-19 | Autogen Research Pty Ltd | Therapeutic molecules |
| US8105615B2 (en) * | 2003-06-06 | 2012-01-31 | Agennix Incorporated | Lactoferrin as an adjuvant in cancer vaccines |
| WO2005014634A1 (en) | 2003-08-12 | 2005-02-17 | Agt Biosciences Limited | A gene and uses therefor |
| US20050215501A1 (en) * | 2003-10-24 | 2005-09-29 | Coley Pharmaceutical Group, Inc. | Methods and products for enhancing epitope spreading |
| US20060275777A1 (en) * | 2005-06-03 | 2006-12-07 | Waelti Ernst R | Novel strategies for protein vaccines |
| US8222214B2 (en) * | 2007-06-01 | 2012-07-17 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Vaccine for the prevention of breast cancer relapse |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040018971A1 (en) * | 2000-12-11 | 2004-01-29 | John Fikes | Inducing cellular immune responses to her2/neu using peptide and nucleic acid compositions |
Non-Patent Citations (1)
| Title |
|---|
| ALEXANDER STOJADINOVIC, MD等: "Quantification and Phenotypic Characterization of Circulating Tumor Cells for Monitoring Response to a Preventive HER2/neu Vaccine-Based Immunotherapy for Breast Cancer: A Pilot Study", 《ANNALS OF SURGICAL ONCOLOGY》 * |
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