CN105816746A - Urinary system kidney tonifying and stone removing traditional Chinese medicine preparation and preparation method - Google Patents
Urinary system kidney tonifying and stone removing traditional Chinese medicine preparation and preparation method Download PDFInfo
- Publication number
- CN105816746A CN105816746A CN201610309340.1A CN201610309340A CN105816746A CN 105816746 A CN105816746 A CN 105816746A CN 201610309340 A CN201610309340 A CN 201610309340A CN 105816746 A CN105816746 A CN 105816746A
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- raw material
- radix
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- 210000003734 kidney Anatomy 0.000 title claims abstract description 32
- 230000002485 urinary effect Effects 0.000 title claims abstract description 20
- 239000004575 stone Substances 0.000 title abstract 3
- 210000000582 semen Anatomy 0.000 claims abstract description 64
- 239000002994 raw material Substances 0.000 claims abstract description 57
- 241000283956 Manis Species 0.000 claims abstract description 22
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims abstract description 22
- 238000001914 filtration Methods 0.000 claims description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 241000220259 Raphanus Species 0.000 claims description 21
- 239000012153 distilled water Substances 0.000 claims description 21
- 238000000605 extraction Methods 0.000 claims description 21
- 238000002156 mixing Methods 0.000 claims description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 239000000706 filtrate Substances 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 14
- 238000005303 weighing Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- 238000001704 evaporation Methods 0.000 claims description 7
- 230000008020 evaporation Effects 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 238000012545 processing Methods 0.000 claims description 7
- 238000010298 pulverizing process Methods 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 7
- 230000000694 effects Effects 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 7
- 238000011282 treatment Methods 0.000 abstract description 6
- 206010023126 Jaundice Diseases 0.000 abstract description 4
- 210000002700 urine Anatomy 0.000 abstract description 4
- 201000010099 disease Diseases 0.000 abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 230000008961 swelling Effects 0.000 abstract description 3
- 231100000419 toxicity Toxicity 0.000 abstract description 2
- 230000001988 toxicity Effects 0.000 abstract description 2
- 244000077995 Coix lacryma jobi Species 0.000 abstract 1
- 241000208688 Eucommia Species 0.000 abstract 1
- 241000758791 Juglandaceae Species 0.000 abstract 1
- 241000274183 Micromeria Species 0.000 abstract 1
- 244000088415 Raphanus sativus Species 0.000 abstract 1
- 241000767840 Semiaquilegia Species 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 235000020234 walnut Nutrition 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 241000699670 Mus sp. Species 0.000 description 7
- 206010007247 Carbuncle Diseases 0.000 description 6
- 230000007812 deficiency Effects 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 6
- 201000000736 Amenorrhea Diseases 0.000 description 5
- 206010001928 Amenorrhoea Diseases 0.000 description 5
- 208000004880 Polyuria Diseases 0.000 description 5
- 231100000540 amenorrhea Toxicity 0.000 description 5
- 230000035619 diuresis Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 208000006820 Arthralgia Diseases 0.000 description 4
- 208000000913 Kidney Calculi Diseases 0.000 description 4
- 206010029148 Nephrolithiasis Diseases 0.000 description 4
- 210000001015 abdomen Anatomy 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 210000000038 chest Anatomy 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- 206010000087 Abdominal pain upper Diseases 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 3
- 206010067482 No adverse event Diseases 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 208000009205 Tinnitus Diseases 0.000 description 3
- 208000019790 abdominal distention Diseases 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 208000006750 hematuria Diseases 0.000 description 3
- 210000001624 hip Anatomy 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 210000000244 kidney pelvis Anatomy 0.000 description 3
- 201000004792 malaria Diseases 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 231100000886 tinnitus Toxicity 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- 206010000060 Abdominal distension Diseases 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000008967 Enuresis Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 206010060710 Galactostasis Diseases 0.000 description 2
- 206010018612 Gonorrhoea Diseases 0.000 description 2
- 208000008930 Low Back Pain Diseases 0.000 description 2
- 206010062575 Muscle contracture Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 208000006111 contracture Diseases 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 208000001786 gonorrhea Diseases 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 230000002175 menstrual effect Effects 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 201000004647 tinea pedis Diseases 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 208000031868 Calculus ureteric Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 206010016059 Facial pain Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010049077 Hernia pain Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 208000000014 Ureteral Calculi Diseases 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000037006 agalactosis Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 238000000280 densification Methods 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 208000013433 lightheadedness Diseases 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 206010036596 premature ejaculation Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 210000004706 scrotum Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 208000000143 urethritis Diseases 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a urinary system kidney tonifying and stone removing traditional Chinese medicine preparation drug and a preparation method, and belongs to the medicine field. The drug is prepared from walnuts, herba lysimachiae, semen cuscutae, radix polygni multiflori, pericarpium arecae, bark of eucommia, radix achyranthis bidentatae, radish leaves, squama manis, rhizoma chuanxiong, folium pyrrosiae, muskroot-like semiaquilegia roots, fried pericarpium citri reticulatae viride, herba dianthi, coix seeds, herb of twoflower micromeria and herba artemisiae scopariae. According to the drug, the treatment effects of clearing damp-heat, increasing urine and removing stone, eliminating dampness and removing jaundice and removing toxicity and diminishing swelling are achieved through scientific compatibility of all the raw material drugs, the treatment period is short, the effective time is long, the disease is not prone to relapse, the preparation method is scientific and effective, the cost is low, and the drug is suitable for being massively popularized in medicine industry.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of urinary system kidney tonifying calculus Chinese medicine preparation and preparation method.
Background technology
Renal calculus refers to betide the calculus of renal calices, renal pelvis and renal pelvis and ureter connecting portion.Majority is positioned at renal pelvis renal calices, and excess of the kidney matter calculus is rare, and there are single or multiple circle, oval or obtuse triangle densification shadow, high and uniform density in plain film display kidney district, and how smooth edge is, but also has rough in Fructus Mori shape.Kidney is the lithogenous main portions of urinary system shape, the calculus at other any positions can be primary in kidney, ureteral calculus is almost all from kidney, and renal calculus is more easy to coup injury kidney than other any position calculus, and therefore early diagnosis and therapy is extremely important.
The kidney invigorating calculus medicament in the market, mainly by the diuresis of medicine, increases uroflow amount, promotes that thing urinary catheter is coiled, and beneficially calculus is discharged.But widespread treatments is the most thorough, and it is long to have the treatment phase, the shortcomings such as effective time is short, easy recurrence.
Summary of the invention
For the deficiencies in the prior art, the invention provides a kind of urinary system kidney tonifying calculus Chinese medicine preparation and preparation method, have the treatment phase short, effective time is long, is difficult to the advantages such as recurrence.
For realizing object above, the present invention is achieved by the following technical programs: the invention provides a kind of urinary system kidney tonifying calculus Chinese medicine preparation, the raw material of following weight portion is prepared from: Semen Juglandis 5-12 part, Herba Lysimachiae 3-10 part, Semen Cuscutae 3-10 part, Radix Polygoni Multiflori 2-10 part, Pericarpium Arecae 5-12 part, Cortex Eucommiae 1-5 part, Radix Achyranthis Bidentatae 1-6 part, radish 3-10 part, Squama Manis 1-5 part, Rhizoma Chuanxiong 2-11 part, Folium Pyrrosiae 1-8 part, Radix Semiaquilegiae 1-6 part, parch skin 2-3 part, Herba Dianthi 1-8 part, Semen Coicis 1-5 part, Herba Micromeriae Biflorae 1-6 part, Herba Artemisiae Scopariae 2-6 part；
Its preparation method is:
(1) Semen Juglandis, Herba Lysimachiae, Semen Cuscutae, Radix Polygoni Multiflori, the Cortex Eucommiae, Pericarpium Arecae are weighed the most by weight, raw material A must be mixed, put into pulverizer and carry out pulverization process 30-50min, then be ground processing, the fine powder of 180 mesh crossed by raw material after grinding, standby；
(2) weigh Radix Achyranthis Bidentatae, radish, Squama Manis, Rhizoma Chuanxiong, Folium Pyrrosiae, Radix Semiaquilegiae by weight, raw material B must be mixed, immerse and ethanol solution soaks 3-5h, then big fire heating extraction 1-2h, then slow fire heating extraction 1-2h, filter to get filtrate, standby；
(3) weighing parch skin, Herba Dianthi, Semen Coicis, Herba Micromeriae Biflorae, Herba Artemisiae Scopariae by weight, must mix raw material C, put into container, addition is the distilled water of mixing raw material C8-10 times, decocts 3-4h, filter, obtain filtering residue and extracting solution after soaking 5-6h；In filtering residue, addition is the distilled water of filtering residue 6-8 times again, decocts 2-3h, filters, obtains filtering residue and extracting solution；Finally, addition is the distilled water of filtering residue 4-6 times, heated and boiled 1-2h, filters, obtains filtering residue and extracting solution, merge three extracting solution, standby；
(4) fine powder standby obtained by step (1)-(3), filtrate and united extraction liquid being mixed, evaporation, except water, makes tablet medicine.
Preferably, the raw material of following weight portion it is prepared from: Semen Juglandis 6-10 part, Herba Lysimachiae 4-8 part, Semen Cuscutae 4-9 part, Radix Polygoni Multiflori 3-8 part, Pericarpium Arecae 5-12 part, Cortex Eucommiae 2-4 part, Radix Achyranthis Bidentatae 2-5 part, radish 4-8 part, Squama Manis 2-4 part, Rhizoma Chuanxiong 4-10 part, Folium Pyrrosiae 2-6 part, Radix Semiaquilegiae 2-5 part, parch skin 2-3 part, Herba Dianthi 2-7 part, Semen Coicis 2-4 part, Herba Micromeriae Biflorae 2-4 part, Herba Artemisiae Scopariae 2-6 part.
Preferably, the raw material of following weight portion it is prepared from: Semen Juglandis 8 parts, Herba Lysimachiae 4 parts, Semen Cuscutae 5 parts, Radix Polygoni Multiflori 4 parts, Pericarpium Arecae 5 parts, the Cortex Eucommiae 3 parts, Radix Achyranthis Bidentatae 2 parts, radish 6 parts, Squama Manis 2 parts, Rhizoma Chuanxiong 6 parts, Folium Pyrrosiae 3 parts, Radix Semiaquilegiae 2 parts, parch skin 3 parts, Herba Dianthi 3 parts, Semen Coicis 2 parts, Herba Micromeriae Biflorae 3 parts, Herba Artemisiae Scopariae 3 parts.
Preferably, the raw material of following weight portion it is prepared from: Semen Juglandis 9 parts, Herba Lysimachiae 5 parts, Semen Cuscutae 6 parts, Radix Polygoni Multiflori 5 parts, Pericarpium Arecae 6 parts, the Cortex Eucommiae 2 parts, Radix Achyranthis Bidentatae 1 part, radish 6 parts, Squama Manis 2 parts, Rhizoma Chuanxiong 7 parts, Folium Pyrrosiae 1 part, Radix Semiaquilegiae 3 parts, parch skin 2 parts, Herba Dianthi 3 parts, Semen Coicis 2 parts, Herba Micromeriae Biflorae 4 parts, Herba Artemisiae Scopariae 3 parts.
Preferably, in described preparation method step (3), the relative concentration of ethanol solution is 80%, measures the 5-6 times amount into mixing raw material B.
Preferably, the described tablet medicine average diameter in preparation method step (4) is 5-8mm.
In the present invention, effect of each raw material is as follows:
The major function of Semen Juglandis is tonifying the kidney to consolidate the essence, warming the lung Dingchuan, can treat cough of suffering from a deficiency of the kidney, and lumbago foot is soft, constipation.
Herba Lysimachiae can suppress to urinate growth and the gathering of oxalic acid crystal, has and prevents the lithogenous effect of calcic, and can be acidified urine, makes calculus be prone to dissolve.
Semen Cuscutae: the kidney invigorating and essence nourishing；Nourishing the liver to improve visual acuity；Gu tire stopping leak.Main soreness of waist and knee joint；Seminal emission；Sexual impotence；Premature ejaculation；Sterile；Quench one's thirst；Stranguria with turbid discharge；The enuresis；Blurred vision tinnitus；Frequent fetal movement；Miscarriage；Have loose bowels.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down；Externally treating leucoderma.
Radix Polygoni Multiflori: nourishing the blood and yin；Loosening bowel to relieve constipation；Preventing the attack (or recurrence) of malaria；Dispel the wind；Removing toxic substances.Main blood deficiency Light-headedness；Cardiopalmus；Insomnia；The soreness of the waist and knees of the hepatic and renal YIN deficiency；Early whitening of beard and hair；Tinnitus；Seminal emission；Dryness of the intestine constipation；Chronic malaria body is empty；Rubella pruritus；Carbuncle sore；Scrofula；Hemorrhoid.
Pericarpium Arecae: promoting the circulation of QI to alleviate the stagnation in middle-JIAO；For abdominal distention, alleviating distention in middle-JIAO de-swelling and pain relieving, it is adaptable to the abdominal distention caused by stagnation of QI in spleen and stomach, often and Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae equivalent is used.
The Cortex Eucommiae: sweet in the mouth, warm in nature；There are liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, consolidate through antiabortive effect；The lumbago and skelalgia or aching and limp unable that insufficiency of kidney-YANG causes can be treated, the diseases such as born of the same parents' tire that deficiency of liver-QI causes is not solid, scrotum pruritus due to damp pathogen.
Radix Achyranthis Bidentatae: promoting blood circulation to remove blood stasis, damp eliminating diuresis, heat-clearing and toxic substances removing.Control gonorrhea, hematuria, women's amenorrhea, lump in the abdomen, rheumatic arthritis, tinea pedis, edema, dysentery, malaria, diphtheria, carbuncle, traumatic injury.
Radish: pungent, bitter, temperature；Not disappearing for controlling dyspepsia, chest and diaphragm feeling of fullness makees oh to wait disease；Also has the function of moistening and cleaning throat stomach function regulating；Regulate the flow of vital energy eliminating stagnation: tie for married woman's breast, galactostasis, laryngopharynx swelling and pain, damp-heat dysentery etc..
Squama Manis: blood circulation promoting and dispersing pathogen accumulation；Stimulate the menstrual flow stimulating milk secretion；Eliminating carbuncle is burst hard.Main blood stasis amenorrhea；Lump in the abdomen；Rheumatic arthralgia；Agalactia；Carbuncle；Scrofula.For amenorrhea abdominal mass, galactostasis, carbuncle sore tumefacting virus, arthralgia, numbness contracture.
Rhizoma Chuanxiong: acrid in the mouth, temperature；Return liver, gallbladder pericardium channel；Blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping, cure mainly menoxenia, amenorrhea dysmenorrhea, puerperal the stagnant stomachache of the stasis of blood, lump in the abdomen lump, pain in chest and hypochondrium, dizziness of having a headache, anemofrigid-damp arthralgia, traumatic injury, ulcer sores.
Folium Pyrrosiae: relieving stranguria by diuresis, lung heat clearing expels the heat-evil.Control pouring pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, carbuncle.
Radix Semiaquilegiae: sweet, bitter, cold；Return liver, stomach warp；Heat-clearing and toxic substances removing: for furuncle furuncle and phyma etc., also can mash external application by this product.
Parch skin: for distending pain in the chest and hypochondrium, hernia pain, nodules of the breast, acute mastitis, stagnation of QI due to dyspepsia, abdominal distention.
Herba Dianthi: nature and flavor: bitter cold；Gui Jing: enter the heart, small intestine meridian；Function: clearing away heat and promoting diuresis, removing blood stasis stimulates the menstrual flow.Cure mainly: gonorrhea urine overstocks, and amenorrhea is obstructed；Being most appropriate to control pyretic stranguria and have hematuria person's (such as acute urethritis, cystitis), often join Radix Paeoniae Rubra, Rhizoma Imperatae, the Radix Rehmanniae, side such as Herba Dianthi dissipates.If heat symptom-complex is more contained, then add and join Fructus Gardeniae, Talcum；The stranguria with blood that urinary system infection in puerperal is caused,
Semen Coicis: nature and flavor: sweet light；Gui Jing: enter spleen tail lung meridian；Function: dampness removing heat clearing away, strengthening the spleen and tonifying the lung；Cure mainly: edema tinea pedis, lack of appetite diarrhea, arthralgia chiefly caused by damp pathogen contracture, lung abscess, acute appendicitis.
Herba Micromeriae Biflorae: acrid in the mouth, temperature；Warming middle-JIAO, regulates the flow of vital energy, pain relieving, control tell inverse, dysphagic, stomachache, stomachache, colic of cold type pain, dry spleen warming the stomach, enter diet, the alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, treat nine kinds of gastric qi pain, the cold pain in face, chest and diaphragm flatulence, tripe abdomen cold type of pain, vomiting is nauseating, dysphagic regurgitation of food from the stomach.
Herba Artemisiae Scopariae: nature and flavor: bitter, taste is trembled with fear.Gui Jing: enter spleen, stomach, liver, gallbladder meridian；Function: clearing away damp-heat, jaundice eliminating subcutaneous ulcer；Cure mainly: jaundice, oliguria with reddish urine, eczema.
The method have the benefit that
Each material medicine scientific compatibility of the present invention, can be with eliminating damp-heat, relieving stranguria by diuresis, and dehumidify jaundice eliminating, and removing toxic substances and promoting subsidence of swelling can promote bile secretion, activates the activity of bile duct, promotes calculus；Clinical practice safety range of the present invention is big, have no side effect, it can in addition contain enhance metabolism, may also speed up calculus while the kidney invigorating to excrete, and it is short to have the treatment phase, effective time is long, is difficult to the advantages such as recurrence, preparation method scientific and effective, simple and practical, it is suitable in the world of medicine's large-scale promotion.
Detailed description of the invention
For making the purpose of the embodiment of the present invention, technical scheme and advantage clearer, below in conjunction with embodiments of the invention, the technical scheme in the embodiment of the present invention is clearly and completely described.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, broadly fall into the scope of protection of the invention.
Embodiment 1:
A kind of urinary system kidney tonifying calculus Chinese medicine preparation, is prepared from by the raw material of following weight portion: Semen Juglandis 7 parts, Herba Lysimachiae 5 parts, Semen Cuscutae 5 parts, Radix Polygoni Multiflori 5 parts, Pericarpium Arecae 6 parts, the Cortex Eucommiae 3 parts, Radix Achyranthis Bidentatae 4 parts, radish 5 parts, Squama Manis 3 parts, Rhizoma Chuanxiong 5 parts, Folium Pyrrosiae 4 parts, Radix Semiaquilegiae 3 parts, parch skin 2 parts, Herba Dianthi 5 parts, Semen Coicis 3 parts, Herba Micromeriae Biflorae 3 parts, Herba Artemisiae Scopariae 4 parts.
Its preparation method is:
(1) weighing Semen Juglandis, Herba Lysimachiae, Semen Cuscutae, Radix Polygoni Multiflori, the Cortex Eucommiae, Pericarpium Arecae the most by weight, obtain mixing raw material A, put into pulverizer and carry out pulverization process 40min, be then ground processing, the fine powder of 180 mesh crossed by the raw material after grinding, standby；
(2) Radix Achyranthis Bidentatae, radish, Squama Manis, Rhizoma Chuanxiong, Folium Pyrrosiae, Radix Semiaquilegiae are weighed by weight, raw material B must be mixed, immersing relative concentration is 80%, amount soaks 3h in the ethanol solution for 5 times amount of mixing raw material B, then big fire heating extraction 1h, slow fire heating extraction 1h again, filters to get filtrate, standby；
(3) weighing parch skin, Herba Dianthi, Semen Coicis, Herba Micromeriae Biflorae, Herba Artemisiae Scopariae by weight, must mix raw material C, put into container, addition is the distilled water of mixing raw material C8 times, decocts 3h, filter, obtain filtering residue and extracting solution after soaking 5h；In filtering residue, addition is the distilled water of filtering residue 6 times again, decocts 2h, filters, obtains filtering residue and extracting solution；Finally, addition is the distilled water of filtering residue 4 times, heated and boiled 1h, filters, obtains filtering residue and extracting solution, merge three extracting solution, standby；
(4) fine powder standby obtained by step (1)-(3), filtrate and united extraction liquid being mixed, evaporation is except water, and making average diameter is 5mm tablet medicine.
Embodiment 2:
A kind of urinary system kidney tonifying calculus Chinese medicine preparation, is prepared from by the raw material of following weight portion: Semen Juglandis 7 parts, Herba Lysimachiae 5 parts, Semen Cuscutae 6 parts, Radix Polygoni Multiflori 4 parts, Pericarpium Arecae 6 parts, the Cortex Eucommiae 2 parts, Radix Achyranthis Bidentatae 3 parts, radish 5 parts, Squama Manis 5 parts, Rhizoma Chuanxiong 6 parts, Folium Pyrrosiae 4 parts, Radix Semiaquilegiae 3 parts, parch skin 2 parts, Herba Dianthi 3 parts, Semen Coicis 2 parts, Herba Micromeriae Biflorae 3 parts, Herba Artemisiae Scopariae 4 parts.
Its preparation method is:
(1) weighing Semen Juglandis, Herba Lysimachiae, Semen Cuscutae, Radix Polygoni Multiflori, the Cortex Eucommiae, Pericarpium Arecae the most by weight, obtain mixing raw material A, put into pulverizer and carry out pulverization process 40min, be then ground processing, the fine powder of 180 mesh crossed by the raw material after grinding, standby；
(2) Radix Achyranthis Bidentatae, radish, Squama Manis, Rhizoma Chuanxiong, Folium Pyrrosiae, Radix Semiaquilegiae are weighed by weight, raw material B must be mixed, immersing relative concentration is 80%, amount soaks 4h in the ethanol solution for 6 times amount of mixing raw material B, then big fire heating extraction 2h, slow fire heating extraction 2h again, filters to get filtrate, standby；
(3) weighing parch skin, Herba Dianthi, Semen Coicis, Herba Micromeriae Biflorae, Herba Artemisiae Scopariae by weight, must mix raw material C, put into container, addition is the distilled water of mixing raw material C10 times, decocts 4h, filter, obtain filtering residue and extracting solution after soaking 6h；In filtering residue, addition is the distilled water of filtering residue 8 times again, decocts 3h, filters, obtains filtering residue and extracting solution；Finally, addition is the distilled water of filtering residue 5 times, heated and boiled 2h, filters, obtains filtering residue and extracting solution, merge three extracting solution, standby；
(4) fine powder standby obtained by step (1)-(3), filtrate and united extraction liquid being mixed, evaporation is except water, and making average diameter is 6mm tablet medicine.
Embodiment 3:
A kind of urinary system kidney tonifying calculus Chinese medicine preparation, is prepared from by the raw material of following weight portion: Semen Juglandis 8 parts, Herba Lysimachiae 6 parts, Semen Cuscutae 5 parts, Radix Polygoni Multiflori 4 parts, Pericarpium Arecae 6 parts, the Cortex Eucommiae 4 parts, Radix Achyranthis Bidentatae 3 parts, radish 5 parts, Squama Manis 4 parts, Rhizoma Chuanxiong 5 parts, Folium Pyrrosiae 4 parts, Radix Semiaquilegiae 3 parts, parch skin 3 parts, Herba Dianthi 4 parts, Semen Coicis 4 parts, Herba Micromeriae Biflorae 4 parts, Herba Artemisiae Scopariae 4 parts.
Its preparation method is:
(1) weighing Semen Juglandis, Herba Lysimachiae, Semen Cuscutae, Radix Polygoni Multiflori, the Cortex Eucommiae, Pericarpium Arecae the most by weight, obtain mixing raw material A, put into pulverizer and carry out pulverization process 30min, be then ground processing, the fine powder of 180 mesh crossed by the raw material after grinding, standby；
(2) Radix Achyranthis Bidentatae, radish, Squama Manis, Rhizoma Chuanxiong, Folium Pyrrosiae, Radix Semiaquilegiae are weighed by weight, raw material B must be mixed, immersing relative concentration is 80%, amount soaks 4h in the ethanol solution for 5 times amount of mixing raw material B, then big fire heating extraction 1h, slow fire heating extraction 1h again, filters to get filtrate, standby；
(3) weighing parch skin, Herba Dianthi, Semen Coicis, Herba Micromeriae Biflorae, Herba Artemisiae Scopariae by weight, must mix raw material C, put into container, addition is the distilled water of mixing raw material C9 times, decocts 3h, filter, obtain filtering residue and extracting solution after soaking 5h；In filtering residue, addition is the distilled water of filtering residue 6 times again, decocts 2h, filters, obtains filtering residue and extracting solution；Finally, addition is the distilled water of filtering residue 4 times, heated and boiled 2h, filters, obtains filtering residue and extracting solution, merge three extracting solution, standby；
(4) fine powder standby obtained by step (1)-(3), filtrate and united extraction liquid being mixed, evaporation is except water, and making average diameter is 8mm tablet medicine.
Embodiment 4:
A kind of urinary system kidney tonifying calculus Chinese medicine preparation, is prepared from by the raw material of following weight portion: Semen Juglandis 8 parts, Herba Lysimachiae 5 parts, Semen Cuscutae 6 parts, Radix Polygoni Multiflori 5 parts, Pericarpium Arecae 6 parts, the Cortex Eucommiae 3 parts, Radix Achyranthis Bidentatae 4 parts, radish 5 parts, Squama Manis 4 parts, Rhizoma Chuanxiong 6 parts, Folium Pyrrosiae 4 parts, Radix Semiaquilegiae 3 parts, parch skin 2 parts, Herba Dianthi 4 parts, Semen Coicis 4 parts, Herba Micromeriae Biflorae 4 parts, Herba Artemisiae Scopariae 4 parts.
Its preparation method is:
(1) weighing Semen Juglandis, Herba Lysimachiae, Semen Cuscutae, Radix Polygoni Multiflori, the Cortex Eucommiae, Pericarpium Arecae the most by weight, obtain mixing raw material A, put into pulverizer and carry out pulverization process 50min, be then ground processing, the fine powder of 180 mesh crossed by the raw material after grinding, standby；
(2) Radix Achyranthis Bidentatae, radish, Squama Manis, Rhizoma Chuanxiong, Folium Pyrrosiae, Radix Semiaquilegiae are weighed by weight, raw material B must be mixed, immersing relative concentration is 80%, amount soaks 5h in the ethanol solution for 6 times amount of mixing raw material B, then big fire heating extraction 2h, slow fire heating extraction 2h again, filters to get filtrate, standby；
(3) weighing parch skin, Herba Dianthi, Semen Coicis, Herba Micromeriae Biflorae, Herba Artemisiae Scopariae by weight, must mix raw material C, put into container, addition is the distilled water of mixing raw material C10 times, decocts 4h, filter, obtain filtering residue and extracting solution after soaking 6h；In filtering residue, addition is the distilled water of filtering residue 6 times again, decocts 3h, filters, obtains filtering residue and extracting solution；Finally, addition is the distilled water of filtering residue 4 times, heated and boiled 2h, filters, obtains filtering residue and extracting solution, merge three extracting solution, standby；
(4) fine powder standby obtained by step (1)-(3), filtrate and united extraction liquid being mixed, evaporation is except water, and making average diameter is 8mm tablet medicine.
Embodiment 5:
A kind of urinary system kidney tonifying calculus Chinese medicine preparation, is prepared from by the raw material of following weight portion: Semen Juglandis 8 parts, Herba Lysimachiae 6 parts, Semen Cuscutae 5 parts, Radix Polygoni Multiflori 4 parts, Pericarpium Arecae 6 parts, the Cortex Eucommiae 3 parts, Radix Achyranthis Bidentatae 3 parts, radish 5 parts, Squama Manis 4 parts, Rhizoma Chuanxiong 5 parts, Folium Pyrrosiae 3 parts, Radix Semiaquilegiae 3 parts, parch skin 2 parts, Herba Dianthi 2 parts, Semen Coicis 3 parts, Herba Micromeriae Biflorae 3 parts, Herba Artemisiae Scopariae 5 parts.
Its preparation method is:
(1) weighing Semen Juglandis, Herba Lysimachiae, Semen Cuscutae, Radix Polygoni Multiflori, the Cortex Eucommiae, Pericarpium Arecae the most by weight, obtain mixing raw material A, put into pulverizer and carry out pulverization process 50min, be then ground processing, the fine powder of 180 mesh crossed by the raw material after grinding, standby；
(2) Radix Achyranthis Bidentatae, radish, Squama Manis, Rhizoma Chuanxiong, Folium Pyrrosiae, Radix Semiaquilegiae are weighed by weight, raw material B must be mixed, immersing relative concentration is 80%, amount soaks 5h in the ethanol solution for 6 times amount of mixing raw material B, then big fire heating extraction 2h, slow fire heating extraction 2h again, filters to get filtrate, standby；
(3) weighing parch skin, Herba Dianthi, Semen Coicis, Herba Micromeriae Biflorae, Herba Artemisiae Scopariae by weight, must mix raw material C, put into container, addition is the distilled water of mixing raw material C10 times, decocts 3h, filter, obtain filtering residue and extracting solution after soaking 5h；In filtering residue, addition is the distilled water of filtering residue 8 times again, decocts 2h, filters, obtains filtering residue and extracting solution；Finally, addition is the distilled water of filtering residue 4 times, heated and boiled 1h, filters, obtains filtering residue and extracting solution, merge three extracting solution, standby；
(4) fine powder standby obtained by step (1)-(3), filtrate and united extraction liquid being mixed, evaporation is except water, and making average diameter is 5mm tablet medicine.
Toxicity test:
Take experiment mice 60, male and female half and half, body weight 16-20g, carry out acute toxicity test.Mice is randomly divided into two groups, often group 30, i.e. matched group and administration group, fasting 12 hours before experiment；
Medicine (concentration is 3.0g/ml, maximum concentration) gavage prepared by embodiments of the invention 1, gavage volume is 2ml/kg, matched group gives normal saline, within one day, be administered once, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.
Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase the most normal.The indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by Chinese medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 16 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Clinical case:
Case selection:
Take and derive from Urology Department patient 100 example in February ,-2016 in May, 2015, male 70 examples, female 30 example, age 35-55 year；
Using method:
Patient's medicine of the present invention for oral use.
The standard of curative effect evaluation:
Effective: to discharge calculus after taking medicine in 1-3 days, have no adverse reaction；
Effective: to discharge calculus after taking medicine in 3-7 days, have no adverse reaction or have slight untoward reaction；
Invalid: after taking medicine latter 7 days, not discharge calculus, and with untoward reaction；
Therapeutic outcome:
Table 1 patient take medicine lithagogue effect statistics example (%)
| Patient profiles | Sum | Effective | Effectively | Invalid | Effective percentage |
| Renal calculus | 100 | 93 | 4 | 3 | 93% |
According to the data of table 1, the present invention is used for the kidney invigorating calculus removing medicine, and effective, instant effect, after taking, 1 week reviewing statistics, has no adverse reaction.
Above example only in order to technical scheme to be described, is not intended to limit；Although the present invention being described in detail with reference to previous embodiment, it will be understood by those within the art that: the technical scheme described in foregoing embodiments still can be modified by it, or wherein portion of techniques feature is carried out equivalent；And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (6)
1. a urinary system kidney tonifying calculus Chinese medicine preparation, it is characterized in that, the raw material of following weight portion be prepared from: Semen Juglandis 5-12 part, Herba Lysimachiae 3-10 part, Semen Cuscutae 3-10 part, Radix Polygoni Multiflori 2-10 part, Pericarpium Arecae 5-12 part, Cortex Eucommiae 1-5 part, Radix Achyranthis Bidentatae 1-6 part, radish 3-10 part, Squama Manis 1-5 part, Rhizoma Chuanxiong 2-11 part, Folium Pyrrosiae 1-8 part, Radix Semiaquilegiae 1-6 part, parch skin 2-3 part, Herba Dianthi 1-8 part, Semen Coicis 1-5 part, Herba Micromeriae Biflorae 1-6 part, Herba Artemisiae Scopariae 2-6 part；
Its preparation method is:
(1) Semen Juglandis, Herba Lysimachiae, Semen Cuscutae, Radix Polygoni Multiflori, the Cortex Eucommiae, Pericarpium Arecae are weighed the most by weight, raw material A must be mixed, put into pulverizer and carry out pulverization process 30-50min, then be ground processing, the fine powder of 180 mesh crossed by raw material after grinding, standby；
(2) weigh Radix Achyranthis Bidentatae, radish, Squama Manis, Rhizoma Chuanxiong, Folium Pyrrosiae, Radix Semiaquilegiae by weight, raw material B must be mixed, immerse and ethanol solution soaks 3-5h, then big fire heating extraction 1-2h, then slow fire heating extraction 1-2h, filter to get filtrate, standby；
(3) weighing parch skin, Herba Dianthi, Semen Coicis, Herba Micromeriae Biflorae, Herba Artemisiae Scopariae by weight, must mix raw material C, put into container, addition is the distilled water of mixing raw material C8-10 times, decocts 3-4h, filter, obtain filtering residue and extracting solution after soaking 5-6h；In filtering residue, addition is the distilled water of filtering residue 6-8 times again, decocts 2-3h, filters, obtains filtering residue and extracting solution；Finally, addition is the distilled water of filtering residue 4-6 times, heated and boiled 1-2h, filters, obtains filtering residue and extracting solution, merge three extracting solution, standby；
(4) fine powder standby obtained by step (1)-(3), filtrate and united extraction liquid being mixed, evaporation, except water, makes tablet medicine.
2. urinary system kidney tonifying calculus Chinese medicine preparation as claimed in claim 1, it is characterized in that, the raw material of following weight portion be prepared from: Semen Juglandis 6-10 part, Herba Lysimachiae 4-8 part, Semen Cuscutae 4-9 part, Radix Polygoni Multiflori 3-8 part, Pericarpium Arecae 5-12 part, Cortex Eucommiae 2-4 part, Radix Achyranthis Bidentatae 2-5 part, radish 4-8 part, Squama Manis 2-4 part, Rhizoma Chuanxiong 4-10 part, Folium Pyrrosiae 2-6 part, Radix Semiaquilegiae 2-5 part, parch skin 2-3 part, Herba Dianthi 2-7 part, Semen Coicis 2-4 part, Herba Micromeriae Biflorae 2-4 part, Herba Artemisiae Scopariae 2-6 part.
3. urinary system kidney tonifying calculus Chinese medicine preparation as claimed in claim 2, it is characterized in that, the raw material of following weight portion be prepared from: Semen Juglandis 8 parts, Herba Lysimachiae 4 parts, Semen Cuscutae 5 parts, Radix Polygoni Multiflori 4 parts, Pericarpium Arecae 5 parts, the Cortex Eucommiae 3 parts, Radix Achyranthis Bidentatae 2 parts, radish 6 parts, Squama Manis 2 parts, Rhizoma Chuanxiong 6 parts, Folium Pyrrosiae 3 parts, Radix Semiaquilegiae 2 parts, parch skin 3 parts, Herba Dianthi 3 parts, Semen Coicis 2 parts, Herba Micromeriae Biflorae 3 parts, Herba Artemisiae Scopariae 3 parts.
4. urinary system kidney tonifying calculus Chinese medicine preparation as claimed in claim 2, it is characterized in that, the raw material of following weight portion be prepared from: Semen Juglandis 9 parts, Herba Lysimachiae 5 parts, Semen Cuscutae 6 parts, Radix Polygoni Multiflori 5 parts, Pericarpium Arecae 6 parts, the Cortex Eucommiae 2 parts, Radix Achyranthis Bidentatae 1 part, radish 6 parts, Squama Manis 2 parts, Rhizoma Chuanxiong 7 parts, Folium Pyrrosiae 1 part, Radix Semiaquilegiae 3 parts, parch skin 2 parts, Herba Dianthi 3 parts, Semen Coicis 2 parts, Herba Micromeriae Biflorae 4 parts, Herba Artemisiae Scopariae 3 parts.
5. urinary system kidney tonifying calculus Chinese medicine preparation as claimed in claim 1, it is characterised in that in described preparation method step (3), the relative concentration of ethanol solution is 80%, measures the 5-6 times amount into mixing raw material B.
6. urinary system kidney tonifying calculus Chinese medicine preparation as claimed in claim 1, it is characterised in that the described tablet medicine average diameter in preparation method step (4) is 5-8mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610309340.1A CN105816746A (en) | 2016-05-10 | 2016-05-10 | Urinary system kidney tonifying and stone removing traditional Chinese medicine preparation and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610309340.1A CN105816746A (en) | 2016-05-10 | 2016-05-10 | Urinary system kidney tonifying and stone removing traditional Chinese medicine preparation and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105816746A true CN105816746A (en) | 2016-08-03 |
Family
ID=56529124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610309340.1A Pending CN105816746A (en) | 2016-05-10 | 2016-05-10 | Urinary system kidney tonifying and stone removing traditional Chinese medicine preparation and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105816746A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1548110A (en) * | 2003-05-24 | 2004-11-24 | 毛友昌 | Calculus-expelling Jinshi bolus and its prepn |
| CN102125605A (en) * | 2010-01-12 | 2011-07-20 | 王�忠 | Urinary system kidney tonifying and stone discharging Chinese medicine preparation |
| CN104001046A (en) * | 2014-05-26 | 2014-08-27 | 河南科技大学第一附属医院 | Oral traditional Chinese medicine preparation for treating urinary calculus and preparation method thereof |
-
2016
- 2016-05-10 CN CN201610309340.1A patent/CN105816746A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1548110A (en) * | 2003-05-24 | 2004-11-24 | 毛友昌 | Calculus-expelling Jinshi bolus and its prepn |
| CN102125605A (en) * | 2010-01-12 | 2011-07-20 | 王�忠 | Urinary system kidney tonifying and stone discharging Chinese medicine preparation |
| CN104001046A (en) * | 2014-05-26 | 2014-08-27 | 河南科技大学第一附属医院 | Oral traditional Chinese medicine preparation for treating urinary calculus and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王钢: "补肾排石汤", 《江苏中医药》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102579912B (en) | Chinese medicinal capsules special for treating acute mastitis and preparation method thereof | |
| CN101912585B (en) | Medicament for treating myoma of uterus and preparation method thereof | |
| CN101700393B (en) | Traditional Chinese medicine composition for treating breast cancer | |
| CN105327205A (en) | Traditional Chinese medicine preparation for treating thyroid cancer | |
| CN104524335B (en) | A kind of pill and preparation method for female endocrine dyscrasia conditioning | |
| CN101904977A (en) | Medicament for treating mastitis and preparation method thereof | |
| CN101433655B (en) | Chinese medicinal composition for treating colpitis | |
| CN100531787C (en) | Chinese-medicinal preparation for treating hysteromyoma and its making method | |
| CN103735934B (en) | A kind of medicine for the treatment of flank pain and preparation method thereof | |
| CN103432412A (en) | Medicament for treating hyperplasia of mammary glands and preparation method thereof | |
| CN102988946A (en) | Traditional Chinese medicine composition for treating pantalgia after childbirth | |
| CN115779064A (en) | Astragalus root strengthening body resistance and preparation and application thereof | |
| CN104587206A (en) | Medicament for treating bedsore and preparation method of medicament | |
| CN107281355A (en) | It is a kind of to be used for mammary gland jam, micromazia, the preparation of the proliferation of mammary gland | |
| CN104491718B (en) | Medicine for treating liver-depression and phlegm-stasis type mammary gland hyperplasia and preparation method | |
| CN105770691A (en) | Medicinal preparation for treating cervical cancer and application thereof | |
| CN105816746A (en) | Urinary system kidney tonifying and stone removing traditional Chinese medicine preparation and preparation method | |
| CN104606661A (en) | Traditional Chinese medicinal galactagogue for treating hypogalactia after cesarean delivery and preparation method of galactagogue | |
| Sun et al. | Basic Knowledge of Chinese Materia Medica | |
| CN103816522A (en) | Chinese medicament for treating hyperplasia of mammary glands | |
| CN104257813B (en) | A kind of Chinese medicine composition of QI and blood regulating and preparation method thereof | |
| CN103223158A (en) | External medicine for treating alopecia | |
| CN103494991B (en) | Traditional Chinese medicine preparation for treating female metrorrhagia and preparation method thereof | |
| CN103285116B (en) | Traditional Chinese medicine preparation for treating influenza of infant | |
| CN108721422B (en) | Pharmaceutical composition for treating mycotic vaginitis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160803 |