CN105789020B - For mass spectrometric pulse sample injection device and mass spectroscopy device - Google Patents
For mass spectrometric pulse sample injection device and mass spectroscopy device Download PDFInfo
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- CN105789020B CN105789020B CN201610278831.4A CN201610278831A CN105789020B CN 105789020 B CN105789020 B CN 105789020B CN 201610278831 A CN201610278831 A CN 201610278831A CN 105789020 B CN105789020 B CN 105789020B
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- capillary
- centrifuge tube
- injection device
- sample injection
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
It is a kind of to be used for mass spectrometric pulse sample injection device and the mass spectroscopy device with the device, the pulse sample injection device includes capillary hollow, centrifuge tube, drive mechanism and control module, the drive mechanism is controlled by the control module, the driving effect of the drive mechanism causes occur relative motion between the centrifuge tube and the capillary hollow, so that the sophisticated sample solution with the centrifuge tube of the capillary hollow is contacted and the sample solution in sample introduction or the disengaging centrifuge tube, the type of drive of wherein described drive mechanism is controlled such that the capillary hollow realizes pulsed sample introduction.The apparatus structure is simple, easy to control, mass spectrometric Pulsed Sampling can be realized, it is ensured that the vacuum of small spectrometer during sample introduction, while mass spectrometric sensitivity and signal intensity can be improved.
Description
Technical field
It is more particularly to a kind of to be set for mass spectrometric pulse sample injection device and mass spectrum the present invention relates to field of analytic instrument
It is standby.
Background technology
Mass spectrograph (Mass Spectrometer, MS) is that a class ionizes material molecule, is separated simultaneously by mass-to-charge ratio
Its intensity is detected to make the instrument of qualitative and quantitative analysis.One complete mass spectrograph it is main by sampling system (including ion gun and
Ion Transmission system), mass analyzer, signal detection system and vacuum system composition.Mass spectrometric ion sampling system includes
Ion gun and ion transport device, it is responsible for producing gaseous ion from sample and is examined sample transfer into mass analyzer
Survey.The quality of ion sampling system performance is related to the quality of the leading indicators such as mass spectrometric sensitivity, resolution ratio.
In small spectrometer, due to volumetric constraint, one-level vacuum chamber is typically only set, when fluid sample is continuous with big flow
During sample introduction, it will the vacuum in destruction vacuum chamber, so as to substantially reduce the sensitivity of small spectrometer.
In order to ensure vacuum during sample introduction in small spectrometer, an existing solution is using the small hair of internal diameter
Tubule carries out sample introduction, reduces the unit interval into the sample in vacuum chamber and mass analyzer.But this method is unfavorable for obtaining
Stronger mass signal.
In order to ensure vacuum during sample introduction in small spectrometer, another solution being widely adopted is to use
DAPI (discontinuous atmospheric pressure lower interface) input mode, ionizes the gaseous ion that produces by the valve pulsed in the middle of DAPI
Enter in vacuum chamber and mass analyzer.
The content of the invention
It is a primary object of the present invention to overcome the deficiencies in the prior art to be used for mass spectrometric Pulsed Sampling there is provided one kind to fill
Put, its is simple in construction, it is easy to control reliable, mass spectrometric Pulsed Sampling can be realized, it is ensured that small spectrometer during sample introduction
Vacuum, while mass spectrometric sensitivity and signal intensity can be improved.Another object is to provide one kind, and there is the pulse to enter
The mass spectroscopy device of sampling device.
To achieve the above object, the present invention uses following technical scheme：
One kind is used for mass spectrometric pulse sample injection device, including capillary hollow, centrifuge tube, drive mechanism and control mould
Block, the drive mechanism is controlled by the control module, the driving effect of the drive mechanism cause the centrifuge tube with it is described
Relative motion occurs between capillary hollow, so that the sophisticated sample solution with the centrifuge tube of the capillary hollow connects
Touch and the sample solution in sample introduction or the disengaging centrifuge tube, wherein the type of drive of the drive mechanism is controlled such that institute
State capillary hollow and realize pulsed sample introduction.
Further：
Also include capillary and support fixed mechanism, the centrifuge tube that the drive mechanism is moved for the driving centrifuge tube
Drive mechanism, the capillary hollow is fixed on the capillary support fixed mechanism.
The centrifuge tube drive mechanism includes stepper motor, screw mandrel, feed screw nut and centrifugation tube support plate, the stepping
Motor is coupled to the screw mandrel, and the feed screw nut is arranged on the screw mandrel, and the centrifugation tube support plate is fixed on the silk
On stem nut, the centrifuge tube is arranged on the centrifugation tube support plate, and the screw mandrel and the feed screw nut are by the motor
The linear motion for being converted into the centrifugation tube support plate, the centrifugation tube support plate carry the centrifuge tube with it is described in
The relative motion occurs between empty capillary.
The screw mandrel is erected to arrangement, and the centrifugation tube support plate is horizontally fixed on the feed screw nut, the silk
Bar and the feed screw nut are described hollow by the linear motion up and down for centrifuging tube support plate that is converted into of the motor
Capillary is erected to the top for being arranged in the centrifuge tube, the centrifugation tube support plate by capillary support fixed mechanism
The centrifuge tube is driven to move up and down to realize its relative motion between the capillary hollow.
The capillary support fixed mechanism includes being erected to the slide bar of arrangement, is fixed on the joint of the upper end of the slide bar
Supporting plate and the capillary pipe connector on the connection supports plate, the capillary hollow are fixed on the capillary
On connector, slide bar through hole is offered on the centrifugation tube support plate, the slide bar passes through the slide bar through hole, so that described
Centrifugation tube support plate can be slided up and down along the slide bar.
Linear bearing is installed on the slide bar through hole of the centrifugation tube support plate, on the outside of the linear bearing with it is described
The ball on the inside of tube support plate interference fit, the linear bearing is centrifuged to be in rolling contact with the slide bar.
The capillary pipe connector leads to structure in being, the capillary pipe connector passes through external screw thread and the connection supports plate
On the screwed hole that opens up be fixedly connected, the capillary hollow is passed through and by the capillary in the middle of the capillary pipe connector
Connector is constrained and fixed, it is preferable that the capillary pipe connector includes annulus and the other end that one end hand twists gradually small cone
Shape structure, the pyramidal structure is provided with the external screw thread for being used for that cooperation to be screwed with the supporting plate.
Capillary pipe-in-pipe is provided between the capillary hollow and the capillary pipe connector, the capillary pipe-in-pipe is
Deformable material, or the capillary pipe-in-pipe and the capillary pipe connector are deformable material, so that in described
Empty capillary can carry out upper-lower position adjustment for the capillary pipe connector, it is preferable that the capillary pipe-in-pipe is rubber
Material, the capillary pipe connector is PEEK or polytetrafluoroethylmaterial material, and the capillary hollow is quartz capillary.
The control module includes dc source, signal generator and motor driver, and the dc source passes through described
Signal generator connects motor driver, and the control signal that the motor driver is produced to signal generator is modulated, raw
Exported into drive signal, and by drive signal to the stepper motor.
A kind of mass spectroscopy device, including mass spectrograph and the sampling device for being connected to the mass spectrometric ion gun, the sample introduction
Device is described pulse sample injection device.
Beneficial effects of the present invention：
According to the pulse sample injection device of the present invention, capillary hollow is fixed on capillary support fixed mechanism, by controlling
Molding block controls centrifuge tube drive mechanism, occurs relative motion between driving centrifuge tube and capillary hollow, so that hollow capillary
The tip of pipe is contacted and the sample solution in sample introduction or disengaging centrifuge tube with the sample solution in centrifuge tube so that capillary hollow
Pulsed sample introduction is realized, the pulse sample injection device according to above-mentioned design is simple in construction, it is easy to control reliable, it can realize that pulse is entered
Sample, it is ensured that the vacuum of small spectrometer during sample introduction, and mass spectrometric sensitivity and signal intensity can be improved.The pulse
Sampling device can be combined with uviol lamp ionization source, electron spray ionisation source plasma source.By Pulsed Sampling, entered per subpulse
Sample in capillary is not full of capillary all the time, but forms fluid column, and tube wall is smaller to the resistance of fluid column, required driving
Fluid column quality also with fluid column enter vacuum chamber in be gradually reduced, this cause sample feeding speed accelerate, be conducive to improve matter
The sensitivity of spectrometer and signal intensity.
The present invention can realize that capillary is contacted with the pulsed on fluid sample surface and pulse period and dutycycle can
Arbitrarily to adjust, it is only necessary to which program parameter preset is the sample size that can reach automatic-control pulse sample introduction cycle and each cycle.
By pulse sample injection device, fluid sample is not continuous sample introduction, and Large Diameter Pipeline capillary can be caused to be able to apply in small-sized mass spectrum
On instrument, and meet the requirement of vacuum.Meanwhile, Pulsed Sampling causes fluid sample to form a section small liquid in capillary
Post, tube wall is smaller to the resistance of small fluid column, and the fluid column quality of required driving enters also with fluid column to be gradually reduced in vacuum chamber,
This causes sample feeding speed to accelerate, and this characteristic can be not only utilized on small-sized mass spectrum, applied to large commercial mass spectrum,
Be conducive to improving the sensitivity detected and signal intensity.
Brief description of the drawings
Fig. 1 is the schematic diagram of the pulse sample injection device whole system of the specific embodiment of the invention.
Fig. 2 is the front view of the pulse sample injection device outside the removing control module of the specific embodiment of the invention.
Fig. 3 is the axonometric drawing of the pulse sample injection device outside the removing control module of the specific embodiment of the invention.
Fig. 4 is the structural representation of a preferred embodiment of mass spectroscopy device of the present invention.
Description of reference numerals is as follows：
1 --- base
2 --- motor cover
3 --- stepper motor
4 --- motor lead screw
5 --- feed screw nut
6 --- linear bearing
7 --- slide bar
8 --- connection supports plate
9 --- capillary pipe connector
10 --- capillary hollow
11 --- centrifugation tube support plate
12 --- centrifuge tube
13 --- mass spectrograph
14 --- ion gun
Embodiment
Embodiments of the present invention are elaborated below.It is emphasized that what the description below was merely exemplary,
The scope being not intended to be limiting of the invention and its application.
Refering to Fig. 1 to Fig. 4, in one embodiment, one kind is used for mass spectrometric pulse sample injection device, including hollow capillary
Pipe 10, capillary support fixed mechanism, centrifuge tube 12, centrifuge tube drive mechanism and control module, the one end of capillary hollow 10
For being connected in the vacuum chamber of mass spectrograph 13, the other end as sample feeding end, for the sample solution in centrifuge tube 12
Contact, the capillary hollow 10 is fixed on the capillary support fixed mechanism, and the centrifuge tube drive mechanism is by described
Control module is controlled, and drives between the centrifuge tube 12 and the capillary hollow 10 and occurs relative motion, so that described hollow
The sophisticated sample solution with the centrifuge tube 12 of capillary 10 is contacted and the sample in sample introduction or the disengaging centrifuge tube 12
Solution, wherein the type of drive of the centrifuge tube drive mechanism is controlled such that the capillary hollow 10 realizes that pulsed is entered
Sample.
In addition, drive mechanism can also drive capillary hollow 10 relative to the driving machine that centrifuge tube 12 is moved
Structure, can also be while driving capillary hollow 10 and centrifuge tube 12 to carry out the drive mechanism of relative motion.
In a preferred embodiment, the centrifuge tube drive mechanism include stepper motor 3, screw mandrel 4, feed screw nut 5 and
Tube support plate 11 is centrifuged, the stepper motor 3 is coupled to the screw mandrel 4, and the feed screw nut 5 is arranged on the screw mandrel 4, institute
State centrifugation tube support plate 11 to be fixed on the feed screw nut 5, the centrifuge tube 12 is arranged on the centrifugation tube support plate 11,
The motor is converted into the linear motion for centrifuging tube support plate 11, institute by the screw mandrel 4 with the feed screw nut 5
State centrifugation tube support plate 11 and carry between the centrifuge tube 12 and the capillary hollow 10 and occur the relative motion.
In a more preferred embodiment, the screw mandrel 4 is erected to arrangement, and the centrifugation tube support plate 11 is horizontally fixed on
On the feed screw nut 5, the rotation of the motor is converted into the centrifuge tube with the feed screw nut 5 and supported by the screw mandrel 4
The linear motion up and down of plate 11, the capillary hollow 10 by the capillary support fixed mechanism be erected to be arranged in it is described
The top of centrifuge tube 12, the centrifugation tube support plate 11 drives the centrifuge tube 12 to move up and down to realize itself and the hollow hair
The relative motion between tubule 10.
In a more preferred embodiment, the capillary support fixed mechanism includes being erected to the slide bar 7 of arrangement, is fixed on
The connection supports plate 8 of the upper end of the slide bar 7 and the capillary pipe connector 9 on the connection supports plate 8, it is described in
Empty capillary 10 is fixed on the capillary pipe connector 9, and slide bar through hole, the cunning are offered on the centrifugation tube support plate 11
Bar 7 passes through the slide bar through hole, so that the centrifugation tube support plate 11 can be slided up and down along the slide bar 7.Connection supports plate 8
It can be fixed by the top of nut and slide bar 7.
In a more preferred embodiment, linear bearing 6 is installed on the slide bar through hole of the centrifugation tube support plate 11,
The outside of linear bearing 6 is interference fitted with the centrifugation tube support plate 11, the ball and the cunning of the inner side of linear bearing 6
Bar 7 is in rolling contact.
In a more preferred embodiment, structure is led to during the capillary pipe connector 9 is, the capillary pipe connector 9 passes through
External screw thread is fixedly connected with the screwed hole opened up on the connection supports plate 8, and the capillary hollow 10 connects from the capillary
Pass through in the middle of joint 9 and constrained and fixed by the capillary pipe connector 9.Preferably, the capillary pipe connector 9 includes one end
The stubborn annulus of hand and the other end gradually small pyramidal structure, the pyramidal structure are provided with for being screwed with the connection supports plate
The external screw thread of cooperation.
In a more preferred embodiment, it is provided with capillary between the capillary hollow 10 and the capillary pipe connector 9
Pipe-in-pipe, the capillary pipe-in-pipe is deformable material, or the capillary pipe-in-pipe is with the capillary pipe connector 9
Deformable material, so that the capillary hollow 10 can carry out upper-lower position adjustment for the capillary pipe connector 9.It is excellent
Selection of land, the capillary pipe-in-pipe be elastomeric material, the capillary pipe connector 9 be PEEK or polytetrafluoroethylmaterial material, it is described in
Empty capillary 10 is quartz capillary.
Capillary hollow 10 under the constraints, is perpendicularly inserted in centrifuge tube 12 in capillary pipe connector 9 and capillary pipe-in-pipe
Sample solution in.Under the pressure at two ends of capillary hollow 10 difference or other driving forces, sample solution is fed in mass spectrograph.
In certain embodiments, pulse sample injection device also includes base 1 and motor cover 2, and the motor cover 2 can pass through screw
It is fixed on the base 1, the slot structure mutually agreed with the stepper motor 3 is provided with the motor cover 2, passes through the groove
The stepper motor 3 is fixed in the motor cover 2 by structure, the lower end of the capillary support fixed mechanism and the base
1 is fixedly connected, and the base 1, the motor cover 2, the motor, capillary support fixed mechanism are fixed as one, shape
Into certain counterweight, stable sampling device can be played a part of.
In certain embodiments, the control module includes dc source, signal generator (or signal source) and motor
Driver, the dc source connects motor driver by the signal generator, and signal occurs the motor driver
The control signal that device is produced is modulated, and generates drive signal, and drive signal is exported to the stepper motor 3.Centrifuge tube
Up and down motion speed, up and down motion time, highs and lows residence time can adjust according to procedural freedom.
Refering to Fig. 4, in another embodiment, a kind of mass spectroscopy device, including mass spectrograph 13 and it is connected to the mass spectrograph
The sampling device of ion gun 14 in 13 vacuum chamber, the sampling device can fill for the Pulsed Sampling of foregoing any embodiment
Put.
Specific embodiment, its principle and the advantage of the present invention is further described below in conjunction with accompanying drawing.
Fig. 1 show the structure and principle schematic of a specific embodiment of the invention, and pulse sample injection device includes signal
The mechanical structure in source, motor driver and pulse sample injection device.
As shown in figure 1, in a preferred embodiment of the invention, signal source is an one-chip computer module, and signal source is also
Can be provided by programs such as the labview at PC ends.Signal source produces four road signals, and exports respectively to motor driver
OPTO, DIR, FREE, CP end, wherein OPTO are public oedoeagus, and DIR is motor drive direction level input, and FREE is off line end, CP
For pulse ends.The input of four tunnels is modulated by motor driver, and four of four road signals of output to the line stepper motor of two-phase four are defeated
Enter end, so as to control the start and stop of stepper motor, motion rotating speed and steering.
As shown in Figure 2 to Figure 3, motor lead screw 4 and feed screw nut 5 coordinate, and feed screw nut 5 fastens with centrifugation tube support plate 11
Connection, centrifugation tube support plate 11 is interference fitted with linear bearing 6, and centrifuge tube 12 is placed on centrifugation tube support plate 11, linear axis
Hold 6 inner side balls to contact with slide bar smooth surface, the start and stop of motor, rotating speed, be diverted through feed screw nut and be converted into centrifuge tube
The steering of start and stop, shuttle speed and up and down motion.
As shown in Figure 2 to Figure 3, in a preferred embodiment of the invention, the time of sample feeding passes through with lower section
Formula is controlled：Capillary hollow 10 is only reached in centrifuge tube 12 and contacted at peak with sample solution, and centrifuge tube 12 is at peak
Residence time is sample injection time.In addition, the solution in capillary hollow and centrifuge tube is all disengaged position.By pre-
If program can arbitrarily control the sample injection time in sample introduction cycle and a cycle.
As shown in Figure 2 to Figure 3, the capillary hollow 10 passes through capillary tube connector 9, and capillary tube connector 9 is for hollow hair
Tubule 10 plays effect of contraction, can be perpendicularly inserted in centrifuge tube 12.Preferably, capillary tube connector one end is taper knot
Structure, and screw cooperations provided with the screw thread on screw thread and connection supports plate 8, the other end is that hand twists annulus, annulus be provided with reticulate pattern or
Straight burr, is conveniently tightened.Capillary pipe connector 9 has the ability of certain plastic deformation, it is preferable that can use PEEK or poly-
The materials such as tetrafluoroethene.
As shown in Figure 2 to Figure 3, connection supports plate 8 is compressed and matched somebody with somebody by being screwed with the threaded upper ends of slide bar 7 by nut with slide bar 7
Close, capillary pipe connector 9 remains static all the time, and with it relative motion occurs for centrifuge tube 12.The position of centrifuge tube 12 can be with
Manually adjusting for vertical direction is carried out in capillary pipe connector.
As shown in Figure 2 to Figure 3, base 1 is fixed with motor cover 2 by screw, and one and electric machine structure are machined with motor cover
Motor 3 is fixed in motor cover by the slot structure mutually agreed with, slot structure.The lower end thread segment of slide bar 7 by with the screw thread on base 1
The cooperation in hole is fixedly connected with base 1, and base, motor cover, motor, slide bar are fixed as one, and is formed certain counterweight, is served
The effect of stable sampling device.
Preferably, the capillary hollow 10 is quartz capillary.The external diameter of capillary hollow 10 can be 50~2000 μ
M, internal diameter can be 1~100 μm.
Fig. 4 illustrates a kind of mass spectroscopy device of embodiment, wherein in the pulse sample injection device and small spectrometer of the present invention
The uviol lamp ionization source combination put, it is notable that with the not office of mass spectrometer ion source associated with pulse sample injection device of the present invention
It is limited to the ionization source such as uviol lamp ionization source or electron spray ionisation source (ESI).
Above content is to combine specific/preferred embodiment made for the present invention be further described, it is impossible to recognized
The specific implementation of the fixed present invention is confined to these explanations.For general technical staff of the technical field of the invention,
Without departing from the inventive concept of the premise, it can also make some replacements or modification to the embodiment that these have been described,
And these are substituted or variant should all be considered as belonging to protection scope of the present invention.
Claims (12)
1. one kind is used for mass spectrometric pulse sample injection device, it is characterised in that including capillary hollow, centrifuge tube, drive mechanism
And control module, the drive mechanism controls by the control module, the driving effect of the drive mechanism cause it is described from
Occurs relative motion between heart pipe and the capillary hollow, so that in the sophisticated and centrifuge tube of the capillary hollow
Sample solution is contacted and the sample solution in sample introduction or the disengaging centrifuge tube, wherein the type of drive of the drive mechanism is through control
Make to cause the capillary hollow to realize pulsed sample introduction.
2. pulse sample injection device as claimed in claim 1, it is characterised in that also support fixed mechanism including capillary, described
Drive mechanism is drives the centrifuge tube drive mechanism that the centrifuge tube is moved, and the capillary hollow is fixed on the capillary
On pipe support fixed mechanism.
3. pulse sample injection device as claimed in claim 2, it is characterised in that the centrifuge tube drive mechanism includes stepping electricity
Machine, screw mandrel, feed screw nut and centrifugation tube support plate, the stepper motor are coupled to the screw mandrel, and the feed screw nut installs
On the screw mandrel, the centrifugation tube support plate is fixed on the feed screw nut, and the centrifuge tube is arranged on the centrifuge tube
In supporting plate, the stepper motor is converted into the straight of the centrifugation tube support plate by the screw mandrel with the feed screw nut
Line is moved, and the centrifugation tube support plate, which is carried between the centrifuge tube and the capillary hollow, occurs the relative motion.
4. pulse sample injection device as claimed in claim 3, it is characterised in that the screw mandrel is erected to arrangement, the centrifuge tube
Supporting plate is horizontally fixed on the feed screw nut, and the screw mandrel turns the rotation of the stepper motor with the feed screw nut
The linear motion up and down of the centrifugation tube support plate is turned to, the capillary hollow supports fixed mechanism to erect by the capillary
The top of the centrifuge tube is on the spot arranged in, the centrifugation tube support plate drives the centrifuge tube to move up and down to realize itself and institute
State the relative motion between capillary hollow.
5. pulse sample injection device as claimed in claim 4, it is characterised in that the capillary support fixed mechanism includes erectting
Ground arrangement slide bar, be fixed on the connection supports plate of the upper end of the slide bar and the capillary on the connection supports plate
Pipe connector, the capillary hollow is fixed on the capillary pipe connector, and slide bar is offered on the centrifugation tube support plate
Through hole, the slide bar passes through the slide bar through hole, so that the centrifugation tube support plate can be slided up and down along the slide bar.
6. pulse sample injection device as claimed in claim 5, it is characterised in that the slide bar through hole of the centrifugation tube support plate
On linear bearing is installed, with the centrifugation tube support plate interference fit on the outside of the linear bearing, on the inside of the linear bearing
Ball be in rolling contact with the slide bar.
7. pulse sample injection device as claimed in claim 5, it is characterised in that the capillary pipe connector leads to structure, institute in being
State capillary pipe connector to be fixedly connected with the screwed hole opened up on the connection supports plate by external screw thread, the capillary hollow
Passed through in the middle of from the capillary pipe connector and constrained and fixed by the capillary pipe connector.
8. pulse sample injection device as claimed in claim 7, it is characterised in that the capillary pipe connector includes one end hand and twists use
Annulus and the other end gradually small pyramidal structure, the pyramidal structure, which is provided with, to be used to screw cooperation with the connection supports plate
External screw thread.
9. pulse sample injection device as claimed in claim 7, it is characterised in that the capillary hollow is connected with the capillary
Be provided with capillary pipe-in-pipe between head, the capillary pipe-in-pipe is deformable material, or the capillary pipe-in-pipe with it is described
Capillary pipe connector is deformable material, so that the capillary hollow can be carried out for the capillary pipe connector
Lower position adjustment.
10. pulse sample injection device as claimed in claim 9, it is characterised in that the capillary pipe-in-pipe is elastomeric material, described
Capillary pipe connector is PEEK or polytetrafluoroethylmaterial material, and the capillary hollow is quartz capillary.
11. the pulse sample injection device as described in any one of claim 3 to 10, it is characterised in that the control module includes straight
Power supply, signal generator and motor driver are flowed, the dc source connects motor driver, institute by the signal generator
State the control signal that motor driver produces signal generator to be modulated, generate drive signal, and drive signal is exported
To the stepper motor.
12. a kind of mass spectroscopy device, including mass spectrograph and the sampling device for being connected to the mass spectrometric ion gun, its feature exist
In the sampling device is the pulse sample injection device described in any one of claim 1 to 11.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610278831.4A CN105789020B (en) | 2016-04-28 | 2016-04-28 | For mass spectrometric pulse sample injection device and mass spectroscopy device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610278831.4A CN105789020B (en) | 2016-04-28 | 2016-04-28 | For mass spectrometric pulse sample injection device and mass spectroscopy device |
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| Publication Number | Publication Date |
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| CN105789020A CN105789020A (en) | 2016-07-20 |
| CN105789020B true CN105789020B (en) | 2017-07-28 |
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| CN111243936A (en) * | 2020-01-17 | 2020-06-05 | 清华大学深圳国际研究生院 | Pulse electrospray ion source, pulse sampling method and mass spectrum detection system |
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| CN104849412A (en) * | 2015-05-29 | 2015-08-19 | 中国石油大学(北京) | In-situ observation testing device for simulating micro oil displacing interface |
| CN105097411A (en) * | 2014-05-21 | 2015-11-25 | 北京理工大学 | Atmospheric pressure interface device and mass spectrometer |
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2016
- 2016-04-28 CN CN201610278831.4A patent/CN105789020B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2029635A (en) * | 1978-08-30 | 1980-03-19 | Leybold Heraeus Gmbh & Co Kg | Mass spectroscopy of fluids leaving a chromatograph |
| CN102478466A (en) * | 2010-11-30 | 2012-05-30 | 中国科学院大连化学物理研究所 | Sampling and sample introduction apparatus for aerosol |
| CN104661758A (en) * | 2012-10-11 | 2015-05-27 | 塞莫费雪科学（不来梅）有限公司 | Apparatus and method for improving throughput in spectrometry |
| CN203672851U (en) * | 2014-01-26 | 2014-06-25 | 中国科学院地球环境研究所 | Multi receiving ion coupled plasma mass spectroscopy sampling system |
| CN105097411A (en) * | 2014-05-21 | 2015-11-25 | 北京理工大学 | Atmospheric pressure interface device and mass spectrometer |
| CN204424208U (en) * | 2015-03-31 | 2015-06-24 | 合肥美亚光电技术股份有限公司 | A kind of sample introduction ionizing system for mass spectrometer |
| CN104849412A (en) * | 2015-05-29 | 2015-08-19 | 中国石油大学(北京) | In-situ observation testing device for simulating micro oil displacing interface |
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| CN105789020A (en) | 2016-07-20 |
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