CN105778555B - A kind of preparation method of simple lycopene oleoresin precipitation purification - Google Patents
A kind of preparation method of simple lycopene oleoresin precipitation purification Download PDFInfo
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- CN105778555B CN105778555B CN201410823965.0A CN201410823965A CN105778555B CN 105778555 B CN105778555 B CN 105778555B CN 201410823965 A CN201410823965 A CN 201410823965A CN 105778555 B CN105778555 B CN 105778555B
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- lycopene oleoresin
- oleoresin
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Abstract
The invention discloses a kind of preparation method of simple lycopene oleoresin precipitation purification, crystal of lycopene is placed in precipitation kettle with dissection, and the vegetable oil for adding is stirred intensification；Material after will heat up again is imported in precipitation tank, opens vacuum valve and precipitation tank is depressurized, and the residual solvent in non-precipitation lycopene oleoresin is extracted, while being filled with nitrogen, 8 24 hours of precipitation in precipitation bottom portion；The advantage of the invention is that：Method is easy, and the time is short, low cost, ensure that lycopene oleoresin free from extraneous odour, because without adding aqueous alcohol, the lycopene oleoresin after precipitation to be unlikely to deteriorate, purity is high, improve lycopene oleoresin quality, safe, the suitable industrialized production of product.
Description
Technical field
The present invention relates to a kind of purification preparation of lycopene, specifically a kind of simple lycopene oleoresin precipitation
The preparation method of purification, belongs to the purification preparation field of lycopene.
Background technology
Lycopene is contained a kind of natural pigment in plant.It is primarily present in the ripening fruits of plant of Solanaceae tomato
In.It is most one of the powerful antioxidant being found in the plant of nature at present.Science proves, the singlet oxygen in human body
With the arch-criminal that oxygen radical is infringement human body self immune system.Effect that lycopene removes free radical outclass other
Carotenoid and vitamin E, its singlet-oxygen quenching speed constant are 100 times of vitamin E.Lycopene is very unstable, and
It is water-insoluble, current maximally effective extracting method is still carried out with organic solvent, but, because water content is very in tomato
Height, lycopene is in water content cellular environment very high, and organic solvent is not easily penetrated into, and causes the consumption of organic solvent
Greatly, extraction efficiency is not also high.
The content of the invention
In order to solve the above problems, the present invention devises a kind of preparation side of simple lycopene oleoresin precipitation purification
Method, precipitation purification is carried out using present invention process, and the time is short, low cost, ensure that lycopene oleoresin free from extraneous odour, due to
Without adding aqueous alcohol, the lycopene oleoresin after precipitation to be unlikely to deteriorate, purity is high, improves lycopene oleoresin
Quality, safe, the suitable industrialized production of product.
The technical scheme is that：
A kind of preparation method of simple lycopene oleoresin precipitation purification, comprises the following steps：
（1）Crystal of lycopene is placed in precipitation kettle with dissection, and the vegetable oil for adding is stirred intensification, leads to
Addition vegetable oil is crossed, is not only able to dilute lycopene oleoresin, increase mobility, oily tree can also be increased in whipping process
The surface area that fat is contacted with vacuum gas-phase, the resistance that residual dissolved goes out in reduction oleoresin, is conducive to residual molten precipitation；
Relative to tradition plus alcohol precipitation technique, due to alcohol inherently solvent, if de- unclean, it is possible to leave
New residual molten-alcohol is residual molten, and the vegetable oil that the present invention is used is the composition that lycopene oleoresin inherently contains, it is not necessary to
Removing, it is also just residual molten without alcohol；In addition, alcohol in the market much all contains plasticiser residue, alcohol precipitation is used
It is possible to bring plasticiser to remain exceeded risk.
（2）By step（1）Material after intensification is imported in precipitation tank, opens vacuum valve and precipitation tank is depressurized, and is extracted
Residual solvent in non-precipitation lycopene oleoresin, while being filled with nitrogen, 8-24 hour of precipitation in precipitation bottom portion.
Residual molten in lycopene oleoresin can be maintained at below 50ppm using after above-mentioned steps of the present invention, meet country relevant
The requirement of standard.And precipitation is purified, the time is short, low cost, ensure that lycopene oleoresin free from extraneous odour, due to without plus
Enter aqueous alcohol, the lycopene oleoresin after precipitation is unlikely to deteriorate, and purity is high, improve lycopene oleoresin quality,
Safe, the suitable industrialized production of product.
Wherein, the step（1）Vegetable oil include safflower seed oil, certain herbaceous plants with big flowers salad or rapeseed oil, the addition of the vegetable oil
Measure the 10%-30% for gross weight.
The step（1）Temperature after intensification is maintained between 30-50 DEG C.
The step（2）The vacuum of precipitation tank is≤- 0.08MPa.
The step（2）It is passed through the pressure≤0.1MPa of nitrogen.
The advantage of the invention is that：Precipitation purification is carried out using present invention process, method is easy, the time is short, low cost, energy
Enough ensure lycopene oleoresin free from extraneous odour, because without the aqueous alcohol of addition, the lycopene oleoresin after precipitation is difficult
Rotten, purity is high, improves lycopene oleoresin quality, safe, the suitable industrialized production of product.
The invention will be further described with reference to the accompanying drawings and examples.
Brief description of the drawings
Fig. 1 is the process chart of the embodiment of the present invention.
Specific embodiment
The preferred embodiments of the present invention are illustrated below, it will be appreciated that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Unless otherwise indicated, the percentage employed in the present invention is percetage by weight.
Embodiment 1
As shown in figure 1, a kind of preparation method of simple lycopene oleoresin precipitation purification, comprises the following steps：
（1）Produced crystal of lycopene is placed in precipitation kettle with dissection, and the vegetable oil for adding is stirred
Intensification is mixed, by adding vegetable oil, is not only able to dilute lycopene oleoresin, increase mobility, may be used also in whipping process
To increase the surface area that oleoresin is contacted with vacuum gas-phase, the resistance that residual dissolved goes out in reduction oleoresin is conducive to residual molten analysis
Go out；
Relative to tradition plus alcohol precipitation technique, due to alcohol inherently solvent, if de- unclean, it is possible to leave
New residual molten-alcohol is residual molten, and the vegetable oil that the present invention is used is the composition that lycopene oleoresin inherently contains, it is not necessary to
Removing, it is also just residual molten without alcohol；In addition, alcohol in the market much all contains plasticiser residue, alcohol precipitation is used
It is possible to bring plasticiser to remain exceeded risk；
（2）By step（1）Material after intensification is imported in precipitation tank, opens vacuum valve and precipitation tank is depressurized, and is extracted
Residual solvent in non-precipitation lycopene oleoresin, while being filled with nitrogen in precipitation bottom portion, prevents the lycopene of purification
It is oxidized, the precipitation time closes precipitation tank vacuum valve after 8-24 hour, opens exhaust-valve.
Residual molten in lycopene oleoresin can be maintained at below 50ppm using after above-mentioned steps, meeting country has
The requirement of pass standard.And precipitation is purified, the time is short, low cost, lycopene oleoresin free from extraneous odour is ensure that, due to not having
Aqueous alcohol, the lycopene oleoresin after precipitation is added to be unlikely to deteriorate, purity is high, improves lycopene oleoresin product
Matter, safe, the suitable industrialized production of product.
Wherein, the step（1）Vegetable oil include safflower seed oil, certain herbaceous plants with big flowers salad, rapeseed oil, the addition of the vegetable oil
It is the 10%-30% of gross weight.
The step（1）Temperature after intensification is maintained between 30-50 DEG C.
The step（2）The vacuum of precipitation tank is≤- 0.08MPa；Nitrogen pressure≤0.1MPa.
It is raw materials used in the present invention to be conventional raw material in the production of this area, can be obtained from market, and for production
Result will not produce influence；Various equipment employed in the present invention, are the conventional equipment used in the production technology of this area,
And operation, the parameter of each equipment etc. is carried out according to routine operation, special feature is had no.
Claims (1)
1. the preparation method that a kind of simple lycopene oleoresin precipitation is purified, it is characterised in that comprise the following steps：
（1）Crystal of lycopene is placed in precipitation kettle with dissection, and the vegetable oil for adding is stirred intensification；
（2）By step（1）Material after intensification is imported in precipitation tank, opens vacuum valve and precipitation tank is depressurized, and extraction does not take off
Residual solvent in molten lycopene oleoresin, while being filled with nitrogen, 8-24 hour of precipitation in precipitation bottom portion；It is described
Step（1）Vegetable oil include safflower seed oil, certain herbaceous plants with big flowers salad or rapeseed oil；The addition of the vegetable oil is the 10%- of gross weight
30%；The step（1）Temperature after intensification is maintained between 30-50 DEG C；The step（2）The vacuum of precipitation tank for≤-
0.08MPa；The step（2）It is passed through the pressure≤0.1MPa of nitrogen.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410823965.0A CN105778555B (en) | 2014-12-26 | 2014-12-26 | A kind of preparation method of simple lycopene oleoresin precipitation purification |
Applications Claiming Priority (1)
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|---|---|---|---|
| CN201410823965.0A CN105778555B (en) | 2014-12-26 | 2014-12-26 | A kind of preparation method of simple lycopene oleoresin precipitation purification |
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| CN105778555A CN105778555A (en) | 2016-07-20 |
| CN105778555B true CN105778555B (en) | 2017-05-31 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1380009A (en) * | 2002-05-29 | 2002-11-20 | 北京普瑞孚天然药物现代纯化和分离研究所有限公司 | Preparation method of lycopene richly containing cis-isomer |
| WO2008032006A1 (en) * | 2006-09-11 | 2008-03-20 | Overseal Natural Ingredients Ltd. | Naturally derived colours with bioactive compounds |
| CN101148631A (en) * | 2007-11-09 | 2008-03-26 | 天津商业大学 | Method for preparing lycopene-enriched vegetable oil |
| CN101184543A (en) * | 2005-04-19 | 2008-05-21 | 爱德华多·萨维奥雷伊 | Method of preparing lycopene-enriched formulations that are free of organic solvents, formulations thus obtained, compositions comprising said formulations and use of same |
| CN101248861A (en) * | 2007-02-22 | 2008-08-27 | 刘洪涛 | Tomato deep-processing method |
| CN101381274A (en) * | 2008-10-16 | 2009-03-11 | 中国农业大学 | Method for removing dissolvent residual from lycopene oleoresin |
-
2014
- 2014-12-26 CN CN201410823965.0A patent/CN105778555B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1380009A (en) * | 2002-05-29 | 2002-11-20 | 北京普瑞孚天然药物现代纯化和分离研究所有限公司 | Preparation method of lycopene richly containing cis-isomer |
| CN101184543A (en) * | 2005-04-19 | 2008-05-21 | 爱德华多·萨维奥雷伊 | Method of preparing lycopene-enriched formulations that are free of organic solvents, formulations thus obtained, compositions comprising said formulations and use of same |
| WO2008032006A1 (en) * | 2006-09-11 | 2008-03-20 | Overseal Natural Ingredients Ltd. | Naturally derived colours with bioactive compounds |
| CN101248861A (en) * | 2007-02-22 | 2008-08-27 | 刘洪涛 | Tomato deep-processing method |
| CN101148631A (en) * | 2007-11-09 | 2008-03-26 | 天津商业大学 | Method for preparing lycopene-enriched vegetable oil |
| CN101381274A (en) * | 2008-10-16 | 2009-03-11 | 中国农业大学 | Method for removing dissolvent residual from lycopene oleoresin |
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| Publication number | Publication date |
|---|---|
| CN105778555A (en) | 2016-07-20 |
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