CN105770810A - Traditional Chinese medicine composition containing folium artemisiae argyi and capable of treating postpartum hemorrhage and preparation method thereof - Google Patents
Traditional Chinese medicine composition containing folium artemisiae argyi and capable of treating postpartum hemorrhage and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition containing folium artemisiae argyi and capable of treating postpartum hemorrhage and a preparation method thereof. The traditional Chinese medicine compound is prepared from the following raw materials in parts by weight: 12-25 parts of folium artemisiae argyi, 13-24 parts of Herba seu Radix Cirsii Japonici, 8-20 parts of Herba Portulacae, 9-19 parts of Cyrtomium Rhizome, 7-18 parts of radix ginseng, 8-19 parts of radix angelica sinensis, 5-12 parts of donkey-hide gelatin, 5-15 parts of Rhizoma Chuanxiong, 3-12 parts of radix angelicae, 2-15 parts of litchi fruit, 3-9 parts of rhizoma zingiberis and 6-10 parts of liquorice root. The traditional Chinese medicine composition conforms to the combination principle of monarch, minister, assistant and guide of traditional Chinese medicine and is reasonable in ingredients and has a mutually synergistic effect; all the herbs are coordinated in proper proportion, so that the traditional Chinese medicine composition has the effects of activating blood and eliminating stasis, reinforcing qi and nourishing blood, calming the liver and eliminating heat, and strengthening chong and stopping bleeding, is capable of effectively treating postpartum hemorrhage, and has the advantages of high pertinence, rapidness in effect taking, short treatment course, high cure rate and high safety.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to the Chinese medicine composition of a kind for the treatment of postpartum hemorrhage containing Folium Artemisiae Argyi
Thing and preparation method thereof.
Background technology
After delivery of baby, 24 hours internal hemorrhage amounts are referred to as postpartum hemorrhage more than 500mL person, and 80% occurred in puerperal 2
In hour.After late postpartum hemorrhage refers to give a birth 24 hours, bleed profusely in the uterus occurred within puerperal,
It is more common in puerperal 1～2 weeks.Postpartum hemorrhage is the complication that term is serious, is cause maternal death four big
One of reason.The most always cause first reason of maternal death at China's postpartum hemorrhage, particularly exist
This situation of Far-away Backward Areas is more prominent.The sickness rate of postpartum hemorrhage accounts for the 2%～3% of childbirth sum, due to
The subjective factors measuring and collecting amount of bleeding is relatively big, and actual sickness rate is higher.
What doctor trained in Western medicine thought postpartum hemorrhage mainly has a following reason: 1. uterine inertia: under normal circumstances, Placenta Hominis is arranged
After going out, uterus muscle fiber shrinks the blood sinus multiple, open between icarceration muscle fiber with contracting immediately, is allowed to temporarily stop blooding.Become silted up
Stagnant blood forms thrombosis, and gradually fibrosis, and total blockage is satisfied in blood sinus chamber.Therefore, any uterine contraction is affected
And the multiple factor that contracts all can cause postpartum hemorrhage.Systemic factor has stages of labor long or in the flue after difficult labour, tranquilizer
Use too much, anaesthetized deep and whole body acute and chronic diseases etc..Local factor has uterus muscle fiber because of twins, amniotic fluid mistake
Many, giant and overextension；The myometrium degeneration repeatedly giving a birth caused；Pregnancy induced hypertension syndrome or
The edema that anemia causes, the oozing of blood after placental abruption；Hysteromyoma or uterine malformation cause uterine contraction to be obstructed；Preposition tire
During dish, the lower uterine segment of Placenta Hominis attachment shrinks bad etc..2. hemorrhage caused by placental retention is shown in " placental retention " bar.
3. soft birth canal injury: fetus is excessive or lopsided, malpresentation, delivery of baby are too fast, operation midwifery is improper
Cause perineum, vagina, cervix uteri, itself or lower uterine segment laceration and cause postpartum hemorrhage.4. coagulation disorders:
It is detained the most long, serious symptom palace at serious symptom placental abruption, amniotic embolism, Severe Pregnancy Induced, stillborn fetus
Under interior infection conditions, cause disseminated inravascular coagulation owing to Placenta Hominis, amniotic fluid or stillborn fetus release rush blood coagulation substance enters blood,
Consume a large amount of thrombin, Chang Jifa postpartum hemorrhage.Additionally, the original leukemia of puerpera, thrombocytopenic are purple
When purplish or white patches on the skin disease, aplastic anemia etc. or merging severe viral hepatitis, also can cause postpartum hemorrhage.5. in puerperal
Palace trophoblastic tumor or submucosal myoma of uterus.Also may result in uterus continual or substantial amounts of bleed.
Postpartum hemorrhage is also known as massive postpartum vaginal bleeding, and the traditional Chinese medical science thinks that the Etiological of massive postpartum vaginal bleeding is as follows: 1. deficient qi and blood, element
Bromhidrosis insufficiency of blood, multiple because of intrapartum hemorrhage more, healthy energy is the most empty, and blood loses and has under one's command, the debility of CHONG and REN meridians and cause hemorrhage；2. the stasis of blood
Blood internal resistance, prolonged lochia, tire thing residual does not goes out, or experiences cold-evil and cause blood stasis and hinder in uterus, and fresh blood must not
Old warp and cause vaginal hemorrhage；3. rage impairing the liver, puerperal, QI and blood was the most empty, and too drastic because of feelings will again, rage impairing the liver, liver is not
Store blood, so that sudden onset of metrorrhagia.
In the treatment of late postpartum hemorrhage, doctor trained in Western medicine mainly to use uterine contraction agent and antibiotic, coordinates if desired and scrapes
Palace art or exploratory laparotomy.Western medical treatment has bigger infringement to womb, is seriously possible to cause sterility and infertility.
The traditional Chinese medical science thinks the treatment to primary disease, when being its principle with symptomatic treatment in acute condition, radical treatment in chronic case.When sudden onset of metrorrhagia,
Anxious when hemostasis is admittedly to take off, find out rapidly the cause of disease simultaneously；After blood gesture is slightly slow, according to the different causes of disease, dialectical control
Treat.As really belong to tire thing not under, within residual uterus, or the long disunion of uterine incision or the person of splitting should perform the operation in time and control
Treat.The treatment of primary disease, should be with first aid as elder generation, during amount of bleeding many gesture urgency, should QI invigorating Gu Chong immediately, or recuperating depleted YANG and rescuing the patient from collapse.
After blood gesture is slightly slow, benefiting QI and nourishing blood, tonifying Chong and Ren channels, blood circulation and removing stasis can be taked respectively according to the different causes of disease, put down
The methods such as liver and clearing heat, for there being tire thing residual person, if desired should row uterine curettage；The uterine incision person of splitting, when with doctor trained in Western medicine
Operation is rescued.
Chinese invention patent application number 201410133331.2 discloses a kind of Chinese medicine composition treating postpartum hemorrhage
Thing, this Chinese medicine preparation includes following Chinese crude drug: Radix Trichosanthis: 3-5 part, Radix Et Rhizoma Rhei 3.5-5 part, Radix Angelicae Sinensis 2.5-5.5
Part, Rhizoma Chuanxiong 3-6 part, Radix Astragali 2-4 part, Ophicalcitum 4-7 part, Radix seu Caulis Verntilaginis Leiocarpae 3-5 part, Radix Codonopsis 1-2.5 part,
Radix Paeoniae Alba 2-4.5 part, Rhizoma Polygoni suffulti 4-6.5 part, Fructus Jujubae 1.5-3 part.Clinical trial shows Chinese medicine composition of the present invention
Thing has certain curative effect to postpartum hemorrhage, but this Chinese medicine composition making step is excessively simple, and the effective ingredient of medicine obtains
Less than making full use of, and in clinical experiment, the reason of postpartum hemorrhage of 200 cases is not described, and causes this Chinese medicine
The uncertainty of compositions treatment postpartum hemorrhage.
Summary of the invention
It is an object of the invention to overcome prior art not enough, it is provided that in a kind for the treatment of postpartum hemorrhage containing Folium Artemisiae Argyi
Drug composition and preparation method thereof, by selecting suitable medical material and regulation compatibility, reach with strong points, effective fast,
The purpose that short treating period, cure rate are high, toxic and side effects is little, safety is high.
For realizing the object of the invention, research and the clinic of Chinese medical theory are tested by inventor's foundation repeatedly, it is provided that
A kind of Chinese medicine composition for the treatment of postpartum hemorrhage containing Folium Artemisiae Argyi and preparation method thereof, its technical scheme is as follows:
The prescription of Chinese medicine composition of the present invention includes the raw material of preparing of following parts by weight:
Folium Artemisiae Argyi 12-25 part, Radix Cirsii Japonici 13-24 part, Herba Portulacae 8-20 part, Rhizoma Osmundae 9-19 part, Radix Ginseng 7-18 part,
Radix Angelicae Sinensis 8-19 part, Colla Corii Asini 5-12 part, Rhizoma Chuanxiong 5-15 part, Radix Angelicae Dahuricae 3-12 part, Fructus Litchi 2-15 part, Rhizoma Zingiberis 3-9
Part and Radix Glycyrrhizae 6-10 part.
In the range of these parts by weight, preferably 3 curative effects more significantly formula:
Formula 1: Folium Artemisiae Argyi 12 parts, Radix Cirsii Japonici 13 parts, Herba Portulacae 8 parts, Rhizoma Osmundae 9 parts, Radix Ginseng 7 parts, Radix Angelicae Sinensis 8
Part, 5 parts of Colla Corii Asini, Rhizoma Chuanxiong 5 parts, the Radix Angelicae Dahuricae 3 parts, Fructus Litchi 2 parts, Rhizoma Zingiberis 3 parts and 6 parts of Radix Glycyrrhizae.
Formula 2: Folium Artemisiae Argyi 25 parts, Radix Cirsii Japonici 24 parts, Herba Portulacae 20 parts, Rhizoma Osmundae 19 parts, Radix Ginseng 18 parts, Radix Angelicae Sinensis
19 parts, 12 parts of Colla Corii Asini, river 5-15 part, the Radix Angelicae Dahuricae 12 parts, Fructus Litchi 15 parts, Rhizoma Zingiberis 9 parts and 10 parts of Radix Glycyrrhizae.
Formula 3: Folium Artemisiae Argyi 19 parts, Radix Cirsii Japonici 13 parts, Herba Portulacae 14 parts, Rhizoma Osmundae 14 parts, Radix Ginseng 13 parts, Radix Angelicae Sinensis
13 parts, 8 parts of Colla Corii Asini, Rhizoma Chuanxiong 10 parts, the Radix Angelicae Dahuricae 7 parts, Fructus Litchi 8 parts, Rhizoma Zingiberis 6 parts and 8 parts of Radix Glycyrrhizae.
The preparation technology of above-mentioned prescription preparation cost invention Chinese medicine composition is comprised the following steps:
S1, weigh Folium Artemisiae Argyi, Radix Cirsii Japonici, Herba Portulacae, Rhizoma Osmundae, Radix Ginseng, Radix Angelicae Sinensis, Colla Corii Asini, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Fructus Litchi,
Rhizoma Zingiberis, Radix Glycyrrhizae, respectively decontamination, clean, and dries, is ground into coarse powder, according to the 6-9 of coarse powder gross weight after section
Times amount adds water, and backflow decocts 1.5-6 hour, filters, merging filtrate, is evaporated to phase under the conditions of 45-65 DEG C
It is the drug extract of 1.25-1.35 to density；
S2, by described drug extract with inlet temperature for 120-140 DEG C, leaving air temp is the centrifugal spray of 70-90 DEG C
Mist is dried and is prepared as medicine cream powder；
S3, described medicine cream powder is substantially soluble in water, drying under reduced pressure, attrition grinding, cross 80-200 mesh sieve,
Raw material fine powder；
S4, the raw material fine powder prepared toward S3 add suitable adjuvant and make finished product Chinese medicine preparation.
Further, utilizing modern general preparation technique, Chinese medicine composition of the present invention can be made into tablet, glue
The Chinese medicine preparation such as wafer, granule or powder.
The source of medical material, nature and flavor used by Chinese medicine composition of the present invention, return through and effect:
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort.Acrid in the mouth, hardship, warm in nature；Return liver,spleen,kidney warp；Have
Qinghua is damp and hot, blood stasis dispelling is regulated the flow of vital energy, effect of blood circulation promoting and blood stasis dispelling.
Radix Cirsii Japonici: this product is dry aerial parts or the root of feverfew Ji；Sweet in the mouth, hardship, cool in nature；GUIXIN, Liver Channel；
There is cooling blood for hemostasis, effect of removing blood stasis to reduce swelling.
Herba Portulacae: this product is the dry aerial parts of portulacaceous plant Herba Portulacae；Sour in the mouth, cold in nature；Return liver, big
Intestinal warp；There is heat-clearing and toxic substances removing, effect of cooling blood for hemostasis.
Rhizoma Osmundae: this product is mainly Dryopteridaceae plant dryopteris crassirhizoma, Athyriaceae plant lunathyrium acrostichoidesChing, ball Pteridiaceae
Plant Matteuccia strthiopteris, Osmundaceae plant osmund, the rhizome of Blechnaceae plant Blechnum orientale Linn., Brainea insignis, Rhizoma Osmundae etc.；
Bitter in the mouth, cool in nature；Return stomach, Liver Channel；Have and kill ascarid, silk ribbon, pinworm, heat clearing away, removing toxic substances, removing heat from blood, effect of hemostasis.
Radix Ginseng: this product is the dry root of Araliaceae Radix Ginseng；Sweet in the mouth, micro-hardship, property is put down；Return spleen, lung, heart channel；
Having strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, the effect calmed the nerves.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica；Sweet in the mouth, pungent, warm in nature；Return liver, the heart, spleen channel；
There is replenishing and activating blood, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.
Colla Corii Asini: this product is that the skin of equine species donkey is through decocting, concentrating the solid gum made；Sweet in the mouth, property is put down；Return lung,
Liver, kidney channel；There is YIN nourishing of enriching blood, moisturize, effect of hemostasis.
Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong；Acrid in the mouth, warm in nature；Return liver, gallbladder, heart channel；Tool
There is blood-activating and qi-promoting, effect of wind-expelling pain-stopping.
The Radix Angelicae Dahuricae: this product is the umbellate form section plant Radix Angelicae Dahuricae or the dry root of Radix angelicae dahuricae；Acrid in the mouth, warm in nature；Return stomach, large intestine,
Lung meridian；There is the dehumidifying of scattered wind, sensible pain relieving, effect of detumescence and apocenosis.
Fructus Litchi: this product Sapindaceae Fructus Litchi platymiscium Fructus Litchi, with root, aril (sarcocarp) and core；Sweet in the mouth, acid,
Warm in nature；Return spleen, Liver Channel；There is spleen invigorating of nourishing blood, effect of promoting the circulation of QI for relieving swelling.
Rhizoma Zingiberis: this product is the dry rhizome of zingiber；Acrid in the mouth, property heat；Return spleen, stomach, kidney, the heart, lung meridian；
Having Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, effect of dampness expectorant.
Radix Glycyrrhizae: this product is glycyrrhizic legume dry root, spring, season in autumn two excavate, and remove fibrous root, dry sweet in the mouth,
Property flat；GUIXIN, lung, spleen, stomach warp；There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, adjust
Effect with all medicines.
The prescription analysis of Chinese medicine composition of the present invention:
The prescription of Chinese medicine composition of the present invention is according to the dialectical cognition to postpartum hemorrhage of the Chinese medicine rationale, it then follows medicine
The compatibility theory of thing, enhances the usage amount of medical material.This prescription is with Folium Artemisiae Argyi and Radix Cirsii Japonici as monarch drug, heat-clearing and toxic substances removing,
Blood circulation promoting and blood stasis dispelling, cooling blood for hemostasis, removing blood stasis to reduce swelling；With Herba Portulacae, Rhizoma Osmundae, Radix Ginseng and when be classified as ministerial drug, strongly invigorating primordial QI,
Invigorating the spleen to benefit the lung, replenishing and activating blood, menstruction regulating and pain relieving, YIN nourishing of enriching blood；With Colla Corii Asini, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Fructus Litchi and Rhizoma Zingiberis it is
Adjuvant drug, YIN nourishing of enriching blood, blood-activating and qi-promoting, dissipate wind dehumidifying, detumescence and apocenosis, spleen invigorating of nourishing blood, promoting the circulation of QI for relieving swelling；With Radix Glycyrrhizae
For making medicine, invigorating the spleen and replenishing QI, relieving spasm to stop pain, the coordinating the actions of various ingredients in a prescription property of medicine.All medicines coordinate, and complement each other, the most collaborative,
Reach tonifying kidney and nourishing yin, blood circulation promoting and blood stasis dispelling, benefiting QI and nourishing blood, calming liver and clearing heat, effect of benefiting qi and nourishing blood, go out puerperal in treatment
Blood aspect has the most significant curative effect.
Compared with prior art, Chinese medicine composition of the present invention has the advantage that
(1) compared with the medicine of Current therapeutic postpartum hemorrhage, Chinese medicine composition of the present invention complies fully with that " the China people are altogether
With state's pharmacopeia " relevant regulations, it is made up of pure natural Chinese herbal medicine, compatibility medicine reasonable, with low cost, all is collaborative, benefit
Control have both, stress conditioning.The medical material effective ingredient preparing Chinese medicine composition of the present invention all uses modern crafts by fully
Purify, thus improve bioavailability.
(2) clinical trial certificate, compared with positive control drug YANGXUE DANGGUI JIAONANG, Chinese medicine composition of the present invention has had
Effect is fast, short treating period, therapeutic effect are good, efficacy stability, safety is high and adverse reaction rate is low advantage.
(3) Chinese medicine composition of the present invention is easily made into various preparation, carries with easy to use, beneficially clinical expansion.
Detailed description of the invention
Hereinafter by specific embodiment, the present invention will be described further, but the present invention will be not limited only to following example.
It will be understood by those skilled in the art that for, the present invention is in addition to following example, without departing from present disclosure, spirit
With the change under conditions of scope, the present invention carried out, combine or replace, be for a person skilled in the art
It will be apparent that be included within the scope of the present invention.
Embodiment 1
The embodiment of the present invention 1 Chinese medicine composition includes the raw material of preparing of following parts by weight:
Folium Artemisiae Argyi 12 parts, Radix Cirsii Japonici 13 parts, Herba Portulacae 8 parts, Rhizoma Osmundae 9 parts, Radix Ginseng 7 parts, Radix Angelicae Sinensis 8 parts, Colla Corii Asini
5 parts, Rhizoma Chuanxiong 5 parts, the Radix Angelicae Dahuricae 3 parts, Fructus Litchi 2 parts, Rhizoma Zingiberis 3 parts and 6 parts of Radix Glycyrrhizae.
Preparation method is as follows:
S1, weigh Folium Artemisiae Argyi, Radix Cirsii Japonici, Herba Portulacae, Rhizoma Osmundae, Radix Ginseng, Radix Angelicae Sinensis, Colla Corii Asini, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Fructus Litchi,
Rhizoma Zingiberis, Radix Glycyrrhizae, respectively decontamination, clean, and dries, is ground into coarse powder, according to the 6 of coarse powder gross weight after section
Times amount adds water, and backflow decocts 4 hours, filters, merging filtrate, is evaporated to relative density under the conditions of 50 DEG C
It it is the drug extract of 1.35；
S2, being 130 DEG C by described drug extract with inlet temperature, leaving air temp is the centrifugal spray drying of 70 DEG C
It is prepared as medicine cream powder；
S3, described medicine cream powder is substantially soluble in water, drying under reduced pressure, attrition grinding, cross 200 mesh sieves, obtain former
Material fine powder；
S4, the raw material fine powder prepared toward S3 add suitable adjuvant and make capsule.
Embodiment 2
The embodiment of the present invention 2 Chinese medicine composition includes the raw material of preparing of following parts by weight:
Folium Artemisiae Argyi 25 parts, Radix Cirsii Japonici 24 parts, Herba Portulacae 20 parts, Rhizoma Osmundae 19 parts, Radix Ginseng 18 parts, Radix Angelicae Sinensis 19 parts,
12 parts of Colla Corii Asini, river 5-15 part, the Radix Angelicae Dahuricae 12 parts, Fructus Litchi 15 parts, Rhizoma Zingiberis 9 parts and 10 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 3
The embodiment of the present invention 3 Chinese medicine composition includes the raw material of preparing of following parts by weight:
Folium Artemisiae Argyi 19 parts, Radix Cirsii Japonici 13 parts, Herba Portulacae 14 parts, Rhizoma Osmundae 14 parts, Radix Ginseng 13 parts, Radix Angelicae Sinensis 13 parts,
8 parts of Colla Corii Asini, Rhizoma Chuanxiong 10 parts, the Radix Angelicae Dahuricae 7 parts, Fructus Litchi 8 parts, Rhizoma Zingiberis 6 parts and 8 parts of Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Chinese medicine composition pharmacodynamic study of the present invention:
The therapeutical effect of Chinese medicine composition of the present invention animal model big to rat postpartum hemorrhage
1. test method
Prepared by model: gestation SD rat all uses same feedstuff sub-cage rearing under same environment, in gestation the 7th
It difference gavage mifepristone 16.6mg/kg (body weight) and misoprostol 0.1mg/kg (body weight), treat pregnant capsule
Discharge, modeling success.
Method: this experiment gestation SD rat (Zhongshan University's animal center provides) 60, body weight 220 ± 10g,
Randomly selecting 10 rats as Normal group, remaining 50 mice is used for building postpartum hemorrhage animal model,
After modeling, rat is randomly divided into: model group, positive drug control group, embodiment 1 group, embodiment 2 groups, enforcement
Example 3 groups, often group 10.Positive drug control group gavage YANGXUE DANGGUI JIAONANG (the limited public affairs of Dabo, south, Jiangxi bodyguard pharmacy
Department, traditional Chinese medicines quasi-word Z36021609), a 10ml/kg, 2 times on the one, takes for after feeding 30 minutes.Will be real
Execute example 1 group, embodiment 2 groups, 3 groups of capsules prepared of embodiment shell, and are prepared as pastille 80% paste,
It is administered 50mg/kg respectively.Normal group and the isopyknic distilled water of model group gavage.Successive administration 15 days, the medication phase
Between observe 6 groups of mices sign performance.Each group rat 2h after last gavage punctures in ventral aorta and takes blood 2.0ml,
Room temperature stands 1h makes blood sample condense, and then centrifugal 10min at 4 DEG C, takes serum, use measured by radioimmunoassay
Estradiol (E2), progesterone (P) content.
Immunohistochemical Method detection estrogen receptor (ER) and the expression of progesterone receptor (PR).Try by SABC
Detection ER, the PR of method shown in agent box location, quantitatively, including specimen process (dehydration, waxdip, embedding), cut
Sheet, dewaxing are to water, dyeing, graphical analysis.Detecting ER, PR with SABC SABC method, concrete operations are pressed
Description is carried out, and result Computer digital image analysis carries out positioning, quantitatively, and detection positive cell rate is (positive thin
Born of the same parents account for total cell percentages in the visual field), measure average gray value.
This experiment total data uses SPSS16.O statistical package to process.Experimental data mean+SD
Represent, compare between group and use one factor analysis of variance.With P ＜ 0.05 for there being significance statistical significance.
2. experimental result
Table 1 each rats in test groups blood serum E2, the content detection result of P
Note: compare with Normal group,**P ＜ 0.01, compares with model group,#P ＜ 0.05,##P ＜ 0.01.
The positive cell rate that table 2 each rats in test groups uterine cancer cell ER and PR expresses compares
Note: compare with Normal group,**P ＜ 0.01, compares with model group,#P ＜ 0.05,##P ＜ 0.01.
From upper table 1,2, comparing with Normal group, the content of E2, P of model group significantly reduces, and gives
The content of E2 and P all can be dramatically increased after giving positive drug and the prepared capsule for treating of the embodiment of the present invention 1,2,3,
Show that medicine of the present invention has preferable curative effect for subinvolution of uterus post-abortion, wherein prepare with embodiment 3
The therapeutic effect of Chinese medicine composition is optimal.Additionally, the result of the test of SABC shows, give positive drug and Ben Fa
All can dramatically increase, after the capsule for treating that bright embodiment 1,2,3 prepares, the positive cell rate that ER and PR expresses,
Result above all shows, Chinese medicine composition of the present invention to the rat estrogen of postpartum hemorrhage and the generation of progestogen and
The expression of corresponding receptor all has regulation effect, is conducive to treating postpartum hemorrhage.
Below it is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred implementation is not construed as
Limitation of the present invention, protection scope of the present invention should be as the criterion with claim limited range.For this skill
For the those of ordinary skill in art field, without departing from the spirit and scope of the present invention, it is also possible to make some changing
Entering and retouch, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (7)
1. the Chinese medicine composition of the treatment postpartum hemorrhage containing Folium Artemisiae Argyi, it is characterised in that described Chinese medicine composition
Thing includes the raw material of preparing of following parts by weight:
Folium Artemisiae Argyi 12-25 part, Radix Cirsii Japonici 13-24 part, Herba Portulacae 8-20 part, Rhizoma Osmundae 9-19 part, Radix Ginseng 7-18 part,
Radix Angelicae Sinensis 8-19 part, Colla Corii Asini 5-12 part, Rhizoma Chuanxiong 5-15 part, Radix Angelicae Dahuricae 3-12 part, Fructus Litchi 2-15 part, Rhizoma Zingiberis 3-9
Part and Radix Glycyrrhizae 6-10 part.
The Chinese medicine composition of the treatment postpartum hemorrhage containing Folium Artemisiae Argyi the most according to claim 1, its feature exists
The raw material of preparing of following parts by weight is included in, described Chinese medicine composition:
Folium Artemisiae Argyi 12 parts, Radix Cirsii Japonici 13 parts, Herba Portulacae 8 parts, Rhizoma Osmundae 9 parts, Radix Ginseng 7 parts, Radix Angelicae Sinensis 8 parts, Colla Corii Asini
5 parts, Rhizoma Chuanxiong 5 parts, the Radix Angelicae Dahuricae 3 parts, Fructus Litchi 2 parts, Rhizoma Zingiberis 3 parts and 6 parts of Radix Glycyrrhizae.
The Chinese medicine composition of the treatment postpartum hemorrhage containing Folium Artemisiae Argyi the most according to claim 1, its feature exists
The raw material of preparing of following parts by weight is included in, described Chinese medicine composition:
Folium Artemisiae Argyi 25 parts, Radix Cirsii Japonici 24 parts, Herba Portulacae 20 parts, Rhizoma Osmundae 19 parts, Radix Ginseng 18 parts, Radix Angelicae Sinensis 19 parts,
12 parts of Colla Corii Asini, Rhizoma Chuanxiong 15 parts, the Radix Angelicae Dahuricae 12 parts, Fructus Litchi 15 parts, Rhizoma Zingiberis 9 parts and 10 parts of Radix Glycyrrhizae.
The Chinese medicine composition of the treatment postpartum hemorrhage containing Folium Artemisiae Argyi the most according to claim 1, its feature exists
The raw material of preparing of following parts by weight is included in, described Chinese medicine composition:
Folium Artemisiae Argyi 19 parts, Radix Cirsii Japonici 18 parts, Herba Portulacae 14 parts, Rhizoma Osmundae 14 parts, Radix Ginseng 13 parts, Radix Angelicae Sinensis 14 parts,
9 parts of Colla Corii Asini, Rhizoma Chuanxiong 10 parts, the Radix Angelicae Dahuricae 7 parts, Fructus Litchi 8 parts, Rhizoma Zingiberis 6 parts and 8 parts of Radix Glycyrrhizae.
5., according to the Chinese medicine composition of the arbitrary described treatment postpartum hemorrhage containing Folium Artemisiae Argyi of claim 1-4, it is special
Levying and be, described Chinese medicine composition is made into tablet, capsule, granule or powder.
6., according to the Chinese medicine composition of the arbitrary described treatment postpartum hemorrhage containing Folium Artemisiae Argyi of claim 1-4, it is special
Levying and be, the preparation technology of described Chinese medicine composition comprises the following steps:
S1, weigh Folium Artemisiae Argyi, Radix Cirsii Japonici, Herba Portulacae, Rhizoma Osmundae, Radix Ginseng, Radix Angelicae Sinensis, Colla Corii Asini, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Fructus Litchi,
Rhizoma Zingiberis, Radix Glycyrrhizae, respectively decontamination, clean, and dries, is ground into coarse powder, according to the 6-9 of coarse powder gross weight after section
Times amount adds water, and backflow decocts 1.5-6 hour, filters, merging filtrate, is evaporated to phase under the conditions of 45-65 DEG C
It is the drug extract of 1.25-1.35 to density；
S2, by described drug extract with inlet temperature for 120-140 DEG C, leaving air temp is the centrifugal spray of 70-90 DEG C
Mist is dried and is prepared as medicine cream powder；
S3, described medicine cream powder is substantially soluble in water, drying under reduced pressure, attrition grinding, cross 80-200 mesh sieve,
Raw material fine powder；
S4, the raw material fine powder prepared toward S3 add suitable adjuvant and make finished product Chinese medicine preparation.
7. the side of the Chinese medicine composition preparing the treatment postpartum hemorrhage containing Folium Artemisiae Argyi as claimed in claim 1
Method, it is characterised in that comprise the following steps:
S1, weigh Folium Artemisiae Argyi, Radix Cirsii Japonici, Herba Portulacae, Rhizoma Osmundae, Radix Ginseng, Radix Angelicae Sinensis, Colla Corii Asini, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Fructus Litchi,
Rhizoma Zingiberis, Radix Glycyrrhizae, respectively decontamination, clean, and dries, is ground into coarse powder, according to the 6-9 of coarse powder gross weight after section
Times amount adds water, and backflow decocts 1.5-6 hour, filters, merging filtrate, is evaporated to phase under the conditions of 45-65 DEG C
It is the drug extract of 1.25-1.35 to density；
S2, by described drug extract with inlet temperature for 120-140 DEG C, leaving air temp is the centrifugal spray of 70-90 DEG C
Mist is dried and is prepared as medicine cream powder；
S3, described medicine cream powder is substantially soluble in water, drying under reduced pressure, attrition grinding, cross 80-200 mesh sieve,
Raw material fine powder；
S4, the raw material fine powder prepared toward S3 add suitable adjuvant and make finished product Chinese medicine preparation.
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