CN1057694C - Plaster for treating hyperosteogeny and its prepn. method - Google Patents

Abstract

The present invention relates to a plaster for treating hyperosteogeny and a preparation method thereof, which is characterized in that the present invention uses antler and aspongopus as monarch medicine, uses turtle shell glue, gecko and aged vinegar as minister medicine, uses pangolin, ground beetle, earth worm, amber, garter snake and scorpion as adjuvant medicine, and uses musk, borneol, etc. as envoy medicine for directly treating diseases. The preparation method alters the manufacturing method of a black plaster and a rubber plaster, namely water solubility matrixes. The present invention overcomes the defects that the black plaster pollutes skins and clothes, and the side effect of lead poisoning of the black plaster, the allergic reaction of the zinc oxide for the rubber plaster, etc. The present invention has the obvious effects of high curative effect and short treatment period, and is worth popularizing and using.

Description

Plaster of treatment hyperosteogeny and preparation method thereof

The present invention relates to a kind of Chinese medicine plaster of hyperosteogeny and preparation method of this plaster for the treatment of.

Occur in neck, breast, the lumbar vertebra of human body, elbow and knee joint, and the hyperosteogeny at position such as calcaneus are a kind of commonly encountered diseases, frequently-occurring disease, and especially middle-older patient is more.This sick the many of plaster external treatment that adopt of Chinese traditional treatment so far.These Chinese medicine plaster select generally that Xin Xiang walks to scurry for use, the Chinese herbal medicine of wind dispelling cold expelling, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving four class functions is main, its substrate mostly is oiliness, can be divided into two classes according to adjuvant and preparation method, one class is that vegetable oil is endured explosive material method, the traditional black plaster that adds adjuvant Plumbum preparatium, another kind of is that adjuvant is the adhesive plaster with medicine of zinc oxide.In " the 128 routine clinical observations of succinum softening the hard mass cream external treatment lumbar vertebra hyperosteogeny " literary composition of delivering as " the Shanxi traditional Chinese medical science " 1993 the 9th the 1st phase of volume, disclosed " succinum softening the hard mass cream ", it is by succinum, Olibanum, Myrrha, Moschus, Pseudobulbus Cremastrae Seu Pleiones, Fructus Gleditsiae Abnormalis, Scorpio, Limax, Radix Angelicae Sinensis, Squama Manis, Radix Achyranthis Bidentatae, Radix Dipsaci, Radix Rehmanniae Preparata, Radix Aconiti Kusnezoffii, Radix Aconiti, Radix Angelicae Pubescentis, Herba Asari, Resina Ferulae, Semen Strychni, Camphora, Radix Et Rhizoma Rhei, Radix Notoginseng, Sanguis Draxonis, Plumbum preparatium, 25-component Chinese crude drugs such as Oleum Sesami are formed in right amount, remove Moschus during preparation, Resina Ferulae, Sanguis Draxonis, outside the Camphora, all the other medical materials then all go into to endure withered removing slag in the Oleum Sesami, descend Plumbum preparatium to become cream again.Arranged " traditional Chinese medical science research " in June, 1994 again, in " ointment for eliminating pain of spur is treated the observation of curative effect of 194 routine hyperosteogenys " literary composition that the 7th volume, the 2nd phase deliver, disclosed " ointment for eliminating pain of spur ", it mainly selects medical materials such as Sanguis Draxonis, Radix Clematidis, Semen Strychni, Moschus, Olibanum, Myrrha, Borneolum Syntheticum, Semen Persicae, Flos Carthami for use, by " Chinese plaster " method for making, also belong to black oiliness lead plaster medicine.In addition in " Five Dragons Wheeling ointment for treating hyperosteogeny 1250 examples " literary composition that the 14th the 9th phase of volume of " Shandong journal of Chinese medicine " nineteen ninety-five delivers, disclosed " Five Dragons Wheeling cream ", its prescription is: Radix Clematidis, Squama Manis, Rhizoma Dioscoreae Nipponicae, FENGXIANCAO, Herba Lycopodii, Myrrha, Olibanum, Herba Erodii, Semen Sinapis Albae, the Radix Angelicae Dahuricae, each 30g of Radix Gentianae Macrophyllae, Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Herba Ephedrae, each 20g of Fructus Schisandrae Chinensis, Sanguis Draxonis 15g, Moschus 5g, Plumbum preparatium is an amount of, its method for making is removed Moschus, Olibanum, Myrrha, outside the Sanguis Draxonis, all the other medical materials also all drop into the interior immersion of vegetable oil and medical material are endured to dried-up, pull medicinal residues out, cast Plumbum preparatium again and make.Above-mentioned three kinds of used Chinese crude drugs of plaster are that aforementioned four class function models belong to, and only are flavour of a drug, dose difference, but all belong to the leaded class black plaster of oils and fats substrate.This class plaster shows poor heat resistance owing to adopt greasing base, has facilitation, easily stream pollutes the scarce limit of skin and medicated clothing and because of all containing more lead, has lead poisoning and causes the side effect of skin allergy.The more important thing is,, can reduce the active ingredient of medicine, thereby influence therapeutic effect because the important step of such plaster manufacturing is the Chinese crude drug of symptomatic treatment to be put into high-temperature vegetable oil endure fried dried-uply to medical material.In above-mentioned three pieces of articles of publishing, in " succinum softening the hard mass cream " treatment lumbar vertebra hyperosteogeny 128 examples, cure rate ability 41.4%, in " ointment for eliminating pain of spur " treatment hyperosteogeny 194 examples, cure rate only 54.6%, in " Five Dragons Wheeling cream " treatment bone matrix hyperplasia 1250 examples, cure rate also only 70%.Illustrated that curative effect is good not enough.Another kind of plaster is a rubber plaster, " GUZHIZENGSHENG YITIELING " as the production of the sharp pharmaceutical Co. Ltd of Henan Province antelope, its disclosed primary raw material has rubber or Corium elephatis extractum, zinc oxide, lanoline, vaseline, Rhizoma Chuanxiong, Flos Carthami, Borneolum Syntheticum, Camphora etc., its method for making is that Rhizoma Chuanxiong, Flos Carthami are made extractum with ethanol or soak with ethanol, Camphora, Borneolum Syntheticum are dissolved back and above adjuvant and extractum mixing, be coated on the elastic force cloth oven dry with plaster bed thickness 0.2mm and form.Though this plaster has overcome above-mentioned scarce limit of black plaster and saturnine side effect etc.But, easily bring the red anaphylaxis of itching of skin because it contains more zinc oxide.When it is manufactured in addition, medicinal ethanol or soak with ethanol in Rhizoma Chuanxiong, the Flos Carthami etc. are extracted into cream, can be volatilized fall a part at the effective ingredient of leaching process Chinese medicine, this plaster additive is more simultaneously, the Chinese medicine content of symptomatic treatment is less, and its usage is that every subsides were changed once in 12 hours.Through on probation, curative effect is also not ideal.

Purpose of the present invention exactly in order to overcome the deficiency of above-mentioned existing plaster, provides a kind of curative effect height, does plaster substrate with the medicinal animal glue of symptomatic treatment, and mainly selecting the animal Chinese crude drug for use is plaster of raw material for treating hyperosteogeny and preparation method thereof.

The present invention realizes by the following technical solutions, it is a substrate by Colla carapax Trionycis, reach the Chinese medical concrete of making by Cornu Cervi, Aspongopus, eupolyphaga, Pheretima, Squama Manis, Gekko Swinhonis, Zaocys, Scorpio, evenly being mixed with powder by Borneolum Syntheticum, succinum, Moschus three flavor medical materials makes, and the ratio of weight and number of above-mentioned each Chinese crude drug is:

Colla carapax Trionycis: 17～50, Cornu Cervi: 15～45, Aspongopus: 10～30, eupolyphaga: 8～25, Pheretima: 7～21, Squama Manis: 7～20, Gekko Swinhonis: 6～18, Zaocys: 5～15, Scorpio: 3～9, Borneolum Syntheticum and succinum are 1～3, Moschus: 0.1～0.3.

The formula optimization parts by weight ratio range of preparation medicine of the present invention is:

Colla carapax Trionycis: 25～45, Cornu Cervi: 25～40, Aspongopus: 18～28, eupolyphaga: 10～20, Pheretima: 9～18, Squama Manis: 8～16, Gekko Swinhonis: 7～15, Zaocys: 5～10, Scorpio: 3～6, Borneolum Syntheticum and succinum are 1～3, Moschus: 0.1～0.3.

The concrete ratio of weight and number of each Chinese crude drug of the present invention can be:

Colla carapax Trionycis: 40, Cornu Cervi: 35, Aspongopus: 27, eupolyphaga: 15, Pheretima: 14, Squama Manis: 10, Gekko Swinhonis: 8, Zaocys: 6, Scorpio: 5, succinum: 2, Borneolum Syntheticum: 2, Moschus: 0.18.

The preparation method of plaster of the present invention is:

1, with after the clean Colla carapax Trionycis pulverizing, with 1: 2.4 weight ratio, put in the Sucus Allii Fistulosi and mix thoroughly, the slow fire heating is the viscose glue shape and makes plaster substrate;

2, clean Cornu Cervi, Aspongopus, eupolyphaga, Pheretima, Gekko Swinhonis, Squama Manis, Zaocys, Scorpio are inserted in Shanxi mature vinegar and the water, the weight ratio of medicine, vinegar, water is 1: 2: 2, be heated to and boil, the heat time of boiling is half an hour, medicinal residues are taken out in cooling back, medicinal liquid after 100 order nets filter, slow fire infusion again, make medicinal liquid be the beading that drips, make Chinese medical concrete.

3, Borneolum Syntheticum, succinum, Moschus are made powder respectively, add in the lump in above-mentioned substrate and the Chinese medical concrete, stir, be coated on the fabric or non-woven fabrics after the sterilization, cut into the plaster piece, pack, make this plaster.

Adjuvants such as the present invention is not leaded, zinc oxide are so it has overcome side effect such as existing plaster lead poisoning, zinc oxide anaphylaxis.Substrate of the present invention is the oleaginous base that water solublity has replaced existing plaster generally to adopt, and has therefore also overcome the scarce limit of polluting skin and medicated clothing.Especially technical solution of the present invention is based on modern Chinese medicine to the pathogenetic correct understanding of hyperosteogeny, has embodied invigorating the kidney and strengthening the bones Zhi Qiben, and disperse blood stasis and dredge collateral, dispersing cold for relieving pain are controlled its mark, and cartilage disappears and increases the Therapeutic Principle of its root of dispelling.Reuse Cornu Cervi, Aspongopus kidney-replenishing, benefiting essence-blood, bone and muscle strengthening, regulating qi to disperse stagnation, reducing swelling and alleviating pain are monarch drug; Select Colla carapax Trionycis, Gekko Swinhonis, mature vinegar hard masses softening and resolving for use, the removing food stagnancy piece removes the hard long-pending ministerial drug that is; Select Squama Manis, eupolyphaga, Pheretima, succinum blood circulation promoting and blood stasis dispelling for use, dredge the meridian passage is joined expelling wind and removing dampness such as Zaocys, Scorpio, and dispersing cold for relieving pain is an adjuvant drug; Moschus, Borneolum Syntheticum are with the gas of fragrance, and saturating flesh bone is opened all keys, the meridian dredging, and the detumescence pain is drawn the through sick be total to of all medicines for making.Add that plaster method for making of the present invention exempted oil and endured explosive material and alcohol-pickled medical material, easily reduce the technology of medical material active ingredient, so the present invention also has short treating period, good effect that curative effect is high.

Below in conjunction with embodiment the present invention is done following further specifying.About enforcement of the present invention (small lot), at first get clean Chinese crude drug by following weight fraction another name:

Colla carapax Trionycis: 300g, Cornu Cervi: 300g, Aspongopus: 230g, eupolyphaga: 160g, Pheretima, Squama Manis, each 100g of Gekko Swinhonis, Zaocys: 60g, Scorpio: 40g, Borneolum Syntheticum: 25g, succinum: 21g, Moschus: 2.5g;

Second step is with Colla carapax Trionycis, Moschus, the succinum of above-mentioned weight, that Borneolum Syntheticum is made powder respectively is standby;

The 3rd step, get the fresh Herba Alii fistulosi cutting of cleaning and be processed into Sucus Allii Fistulosi, take by weighing Sucus Allii Fistulosi 720g (for 2.4 times of Colla carapax Trionycis) and put into pot or other copper, porcelain container, will above-mentioned Colla carapax Trionycis powder add in the Sucus Allii Fistulosi and mix thoroughly through fruit juice mixer, the slow fire heating is the viscose glue shape, and it is stand-by to make this plaster substrate;

The 4th step, with the Cornu Cervi of above-mentioned weight, Aspongopus, eupolyphaga, Pheretima, Squama Manis, Gekko Swinhonis, Zaocys, Scorpio totally 8 flavor medical material meter 1090g insert in the copper pot, according to the ratio of medicine, vinegar, water 1: 2: 2, add Shanxi mature vinegar and each 2180g of water in pot, be heated to and boil, heat is boiled half an hour time, after the cooling medical material is taken out, medicinal liquid is after 100 order nets filter, and the slow fire infusion makes medicinal liquid be the beading that drips again, makes Chinese medical concrete;

The 5th step added the powder and the plaster substrate of above-mentioned Moschus, succinum, Borneolum Syntheticum in the aforementioned Chinese medical concrete in the lump, stirred and promptly got unguentum of the present invention.This unguentum is coated on coating machine (plaster bed thickness 0.4mm is advisable) cuts into the plaster piece on the dehydration elastic force cloth after the sterilization, packs, the standby plaster of the present invention.

This plaster can be treated neck, breast, lumbar vertebra, and the hyperosteogeny at each position such as elbow, knee joint and calcaneus, every subsides 3 days.Above-mentioned each position hyperosteogeny patient 276 example of trial edition plaster treatment all obtain remarkable result.According to the standard of hyperosteogeny healing and produce effects, above-mentioned 276 routine treatment situations are as follows:

1, by the sex branch: male's 140 examples wherein, women's 136 examples are cured 128 example and 125 examples respectively, and produce effects is respectively 12 routine and 11 examples, always cures 253 examples, and cure rate reaches 91.7%, and produce effects 23 examples account for 8.3%;

2, age-based section is divided, and wherein 20～50 years old, totally 155 examples were cured 155 examples, cure rate 100%; More than 50～70 years old, totally 121 examples are cured 98 examples, cure rate 81%, and produce effects 23 examples account for 19%; Total cure rate 91.7%, produce effects 8.3%;

3, by medical history length branch: wherein below 4 years, totally 214 examples are cured 214 examples, cure rate 100%; (contain 10 examples more than 6 years) more than 4 years totally 62 examples are cured 39 examples, cure rate 62.9%, and produce effects 23 examples account for 37.1%, total cure rate 91.7%, produce effects 8.3%;

4, divide by the sick position of hypertrophy: cervical vertebra 61 examples wherein, cure 61 examples; Thoracic vertebra 10 examples are cured 10 examples, and lumbar vertebra 90 examples are cured 79 examples, produce effects 11 examples; Elbow joint 44 examples are cured 40 examples, produce effects 4 examples; Knee joint 56 examples are cured 49 examples, produce effects 7 examples; Calcaneus 15 examples are cured 14 examples, produce effects 1 example; Total cure rate 91.7%, produce effects 8.3%.

5, by treatment time length branch: 28 examples of curing in 3～18 days wherein, 83 examples of curing in 18～36 days, 82 examples of curing in 36～54 days, totally 193 examples of curing in 3～54 day time account for 73.8% of total healing 253 examples.

By on be not difficult to find out (one) this plaster cure rate up to 91.7%, produce effects 8.3%, do not have one the example invalid; (2) this plaster to the right side of fifty patient and to 4 years with interior medical history person, curative effect is higher, cure rate reaches 100%.(3) this plaster is to neck, breast, lumbar vertebra, and each position hypertrophy therapeutic effect of elbow, knee joint and calcaneus is all fine, and the hypertrophy cure rate with neck, thoracic vertebra and calcaneus is higher especially.(4) this plaster treatment cycle shorter, instant effect.

Therefore, plaster of the present invention has promotional value very much.

Claims (4)

1. plaster for the treatment of hyperosteogeny, it is characterized in that it is made by the Chinese crude drug of following weight portion proportioning: Colla carapax Trionycis 17～50, Cornu Cervi 15～45, Aspongopus 10～30, eupolyphaga 8～25, Pheretima 7～21, Squama Manis 7～20, Gekko Swinhonis 6～18, Zaocys 5～15, Scorpio 3～9, Borneolum Syntheticum and succinum are 1～3, Moschus 0.1～0.3.

2. plaster according to claim 1, it is characterized in that the Chinese crude drug and the ratio of weight and number that prepare this plaster are: Colla carapax Trionycis 25～45, Cornu Cervi 25～40, Aspongopus 18～28, eupolyphaga 10～20, Pheretima 9～18, Squama Manis 8～16, Gekko Swinhonis 7～15, Zaocys 5～10, Scorpio 3～6, Borneolum Syntheticum and succinum are 1～3, Moschus 0.1～0.3.

3. plaster according to claim 1 is characterized in that the Chinese crude drug and the ratio of weight and number that prepare this plaster are: Colla carapax Trionycis 40, Cornu Cervi 35, Aspongopus 27, eupolyphaga 15, Pheretima 14, Squama Manis 10, Gekko Swinhonis 8, Zaocys 6, Scorpio 5, Borneolum Syntheticum 2, Moschus 0.18, succinum 2.

4. the preparation method of plaster as claimed in claim 1 is characterized in that: (1) with 1: 2.4 part by weight, is put in the Sucus Allii Fistulosi and is mixed thoroughly after clean Colla carapax Trionycis is pulverized, and the slow fire heating is the viscose glue shape, makes plaster substrate; (2) clean Cornu Cervi, Aspongopus, eupolyphaga, Pheretima, Squama Manis, Gekko Swinhonis, Zaocys, Scorpio are inserted in Shanxi mature vinegar and the water, the weight ratio of medicine, vinegar, water is 1: 2: 2, be heated to and boil, the heat time of boiling is half an hour, after the cooling medical material is taken out, with 100 order net filtering liquid medicines, slow fire infusion filtered liquid medicine makes it be the beading that drips again, makes Chinese medical concrete; (3) succinum, Borneolum Syntheticum and Moschus are pulverized the back and add in above-mentioned plaster substrate and the Chinese medical concrete, stir promptly.