CN105767219A - Preparation method of vegetable oil and vegetable oil product - Google Patents
Preparation method of vegetable oil and vegetable oil product Download PDFInfo
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- CN105767219A CN105767219A CN201610141980.6A CN201610141980A CN105767219A CN 105767219 A CN105767219 A CN 105767219A CN 201610141980 A CN201610141980 A CN 201610141980A CN 105767219 A CN105767219 A CN 105767219A
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- vegetable oil
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- 235000015112 vegetable and seed oil Nutrition 0.000 title claims abstract description 33
- 239000008158 vegetable oil Substances 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 206010021143 Hypoxia Diseases 0.000 claims abstract description 24
- 239000003921 oil Substances 0.000 claims abstract description 20
- 235000019198 oils Nutrition 0.000 claims abstract description 20
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 6
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 6
- 239000007901 soft capsule Substances 0.000 claims abstract description 6
- 238000000605 extraction Methods 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims abstract description 4
- 239000000047 product Substances 0.000 claims description 22
- 206010002660 Anoxia Diseases 0.000 claims description 20
- 241000976983 Anoxia Species 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 230000007953 anoxia Effects 0.000 claims description 20
- 239000012567 medical material Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 241001411214 Cryptolepis sinensis Species 0.000 claims description 7
- 241001660187 Sanicula lamelligera Species 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
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- 238000009835 boiling Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 238000004364 calculation method Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- -1 stirring Chemical compound 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 13
- 229940079593 drug Drugs 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 7
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- 244000000231 Sesamum indicum Species 0.000 abstract 1
- 235000003434 Sesamum indicum Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 12
- 229910052760 oxygen Inorganic materials 0.000 description 12
- 239000001301 oxygen Substances 0.000 description 12
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- 239000008280 blood Substances 0.000 description 7
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- 229920002678 cellulose Polymers 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
- 239000010931 gold Substances 0.000 description 4
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- 208000008035 Back Pain Diseases 0.000 description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 2
- 241001503987 Clematis vitalba Species 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
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- 206010038669 Respiratory arrest Diseases 0.000 description 2
- 244000061458 Solanum melongena Species 0.000 description 2
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- 230000036284 oxygen consumption Effects 0.000 description 2
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- UUTKICFRNVKFRG-WDSKDSINSA-N (4R)-3-[oxo-[(2S)-5-oxo-2-pyrrolidinyl]methyl]-4-thiazolidinecarboxylic acid Chemical compound OC(=O)[C@@H]1CSCN1C(=O)[C@H]1NC(=O)CC1 UUTKICFRNVKFRG-WDSKDSINSA-N 0.000 description 1
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- 241000721047 Danaus plexippus Species 0.000 description 1
- 208000027877 Disorders of Sex Development Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
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- 238000012449 Kunming mouse Methods 0.000 description 1
- 102000010445 Lactoferrin Human genes 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 241001423456 Maianthemum bifolium Species 0.000 description 1
- 206010027423 Metabolic alkalosis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
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- 235000013399 edible fruits Nutrition 0.000 description 1
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- 230000002989 hypothyroidism Effects 0.000 description 1
- 208000018875 hypoxemia Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000001936 parietal effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 201000003144 pneumothorax Diseases 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- 201000004193 respiratory failure Diseases 0.000 description 1
- 210000003019 respiratory muscle Anatomy 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 208000013327 true hermaphroditism Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/02—Other edible oils or fats, e.g. shortenings, cooking oils characterised by the production or working-up
- A23D9/04—Working-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of vegetable oil. The preparation method of vegetable oil is characterized by comprising the following steps: stir-frying oil-bearing crops, i.e., rapeseeds or sesame seeds, so that dried oil-bearing crops are prepared; grinding the dried oil-bearing crops, so that powdered oil-bearing crops are prepared; sending the powder into super-critical equipment, introducing carbon dioxide of 50MPa into the super-critical equipment, wherein flow of the carbon dioxide is 15L/min; extracting the powder at an extraction temperature of 40 DEG C for 2.5 hours; adjusting a separation pressure to 12MPa, so that the vegetable oil is separated; and adding drugs and preparing the mixture into soft capsules. The invention further discloses an application of the vegetable oil in preparations of healthcare products with the effects of improving hypoxia tolerance.
Description
Technical field
The present invention relates to food technology field, be specifically related to preparation method and the vegetable oil products of a vegetable oil.
Background technology
Oxygen is that human body carries out metabolic key substance, is the primary need of human life activity.The oxygen sucked by lung is converted in human body available blood oxygen, and blood carries blood oxygen and inputs the energy needed for biological oxidation to whole body, and therefore oxygen is important substance indispensable in normal activities.Adult is under quiescent condition, and oxygen consumption per minute is about 250ml, if during activity, oxygen consumption just substantially increases.Storage level (including retaining in the oxygen combined in alveolar and with hemoglobin and Lactoferrin) only about about the 1.5L of oxygen in normal body.Work as respiratory arrest, even if internal storage oxygen makes full use of the vital movement that also can only maintain a few minutes., the various metabolic activities of general body all far away from internal oxygen but without before completely depleted, so that it may obvious obstacle occurs.So, body is necessarily dependent upon the supply of extraneous oxygen and is constantly completed picked-up and the transport of oxygen by breathing, blood, blood circulation, to ensure the needs of cell biooxidation.
Respiratory insufficiency may result in anoxia.Due to Central respiration repression, paralysis of respiratory muscle, respiratory tract blocks, Pulmonary Diseases (pneumonia, pulmonary edema etc.), the ventilation of the lung caused by thorax illness (hydrothorax, pneumothorax etc.) and other some diseases (such as hypothyroidism, metabolic alkalosis etc.) and (or) dysfunction of ventilation, can cause hypotonic hypoxemia.
Clinical practice is in improving the medicine of anoxia endurance and tonic is a lot, but these kind toxic and side effects are relatively big, and is inconvenient to take, and up to now, people are look for a kind of making the health product improving anoxia endurance simple, taking convenience.
Summary of the invention
Goal of the invention: in order to solve the problems referred to above, it is an object of the invention to provide the preparation method of a vegetable oil and vegetable oil products.
Technical scheme: it is an object of the invention to by following scheme realization:
The preparation method of one vegetable oil, carries out parch by oil crop Semen Brassicae campestris or Semen Sesami, obtains dried oil crop；Described dried oil crop are ground, obtains pulverous oil crop；Putting in supercritical equipment, pass into the carbon dioxide of 50MPa, flow is 15L/min, and extraction temperature is 40 DEG C, and after extracting 2.5h, adjustment separating pressure is 12MPa, is separated to vegetable oil.
A kind of vegetable oil products improving anoxia endurance, for vegetable oil health product, its contained active component is prepared from by following raw materials in part by weight proportioning: vegetable oil 5 parts, sanicula lamelligera Hance 20 parts, fried 25 parts of August, Herba Maianthemi Bifolii 18 parts, Radix Cryptolepis sinensis 10 parts, 6 parts of Radix Glycyrrhizae, and vegetable oil is that said method preparation obtains.
The health product of described raising anoxia endurance, preparation method step is: take the above-mentioned merging of other medical materials, boiling twice except vegetable oil, collecting decoction, being concentrated into relative density when 65 DEG C is 1.10-1.20, adds ethanol, stirring, makes alcohol content by volume percentage calculation reach 65-85%, stands, filter, when filtrate reduced in volume is to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, and by concentrated solution spray drying, gained granular powder is broken into dry extract, add vegetable oil, make soft capsule.
The health product of described raising anoxia endurance, in preparation method, decocting condition is: first time amount of water is the 8-12 times amount of medical material weight, decocts 1-2h, and second time amount of water is the 6-10 times amount of medical material weight, decocts 1-2h.
The health product of described raising anoxia endurance, in preparation method, spray drying condition is: inlet temperature is 90-110 DEG C, and leaving air temp is 60-90 DEG C, and temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
The health product of described raising anoxia endurance improve the application in anoxia endurance health product in preparation.
Sanicula lamelligera Hance is Umbelliferae sanicle platymiscium sanicula lamelligera Hance SaniculalamelligeraHance, with all herbal medicine, cold expelling cough-relieving, promoting the circulation of blood dysmenorrhea.For cough due to wind and cold, pertussis, menoxenia, amenorrhea, lumbago.
August explodes, Classification system HolboelliafargesiiReaub., for fallen leaves woody climber, high 10m.Bark has obvious point-like protruding, and branch is brown or brown；Minor matters place harbors perula, and bottom person is slightly with wooden, top papery, all without hair.Trifoliolate leaf, clusters in branch end, and petiole is thin and delicate, long 6～8cm, vanelets oval, width egg shape or long oval etc., length and width change greatly, the blunt circle of tip, central nick or have short point, basal circular or wide wedge shape, sometimes in micro-heart, full edge or in wavy, usual 5～6 pairs of lateral vein.Flower unisexuality, hermaphroditism, aubergine, raceme axil is raw, is about 8cm, and male flower is less, most, and is born in inflorescence top, has squamella, and perianth 3, stamen 6, filigree is flat；Female flower 1～3, and is born in inflorescence bottom, bract wire lanceolar, and perianth 3, stamen 6, filigree is flat；Female flower 1～3, and is born in inflorescence bottom, bract wire lanceolar, perianth 3, and wide ellipse is blunt nosed, has staminodium 6, carpel 3～12, and from life, stigma head, ovary cylindrical shape or slightly bent, upper Room 1, parietal placenta, ovule is most.Sarcocarp matter, oblong, aubergine time ripe, ftractures along ventral suture.Seed sealene triangle, slightly flat, rufous, the vertical wrinkle of tool is fine and closely woven and glossy, is embedded in canescence fruit flesh, and hilum is slightly partial to, its other spongy strophiole of visible white.4～May of florescence, really 8～October of phase.Soothing the liver, the kidney invigorating, pain relieving, diuresis, parasite killing.Cure mainly: stomachache, colic, painful and swollen testis, lumbago, seminal emission, menoxenia, leucorrhea, uterine prolapse.Distending pain, amenorrhea dysmenorrhea, dysuria, snake bite and insect sting is coerced for gastral cavity.
Herba Maianthemi Bifolii is the herb of liliaceous plant Herba Maianthemi Bifolii, cooling blood for hemostasis, heat-clearing and toxic substances removing, main haematemesis, hematuria, menorrhagia, traumatic hemorrhage, sore, carbuncle and painful swelling.Classification system is Maianthemumbifolium (L.) Fr.Schmidt.
Radix Cryptolepis sinensis Latin is called Cryptolepissinensis (Lour.) Merr., weak woody climber, has milk；The usual bronzing of sprig, diameter about 1 millimeter, without hair.Leaf Long Circle.Seed Long Circle, is about 1 centimetre, wide 2 millimeters, brown, top tool white thin,tough silk matter kind hair.Heat-clearing and toxic substances removing, eliminating stasis to stop pain, hemostasis.For hemoptysis of pulmonary tuberculosis, lung-heat is spat blood, gastrorrhagia, venom, sore ulcer, scabies, traumatic injury knife injury.Summer, autumn gather, using fresh herb or dry.The present invention adopts all herbal medicine.
Beneficial effect:
From theory of Chinese medical science, in we, sanicula lamelligera Hance, August explode soothing the liver, and the kidney invigorating is monarch drug, and Herba Maianthemi Bifolii, Radix Cryptolepis sinensis heat-clearing and toxic substances removing are ministerial drug, and Radix Glycyrrhizae is adjuvant, and all medicines are harmonious, and plays benefiting QI for activating blood circulation effect altogether, is used for improving anoxia endurance.
Detailed description of the invention
Form by the following examples, the foregoing of the present invention is described in further detail again, but this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to Examples below, and all technology realized based on foregoing of the present invention belong to the scope of the present invention.
Embodiment 1: oil crop Semen Brassicae campestris 10kg is carried out parch, obtains dried oil crop；Described dried oil crop are ground, obtains pulverous oil crop；Putting in supercritical equipment, pass into the carbon dioxide of 50MPa, flow is 15L/min, and extraction temperature is 40 DEG C, and after extracting 2.5h, adjustment separating pressure is 12MPa, is separated to vegetable oil.
Embodiment 2: oil crop Semen Sesami 10kg is carried out parch, obtains dried oil crop；Described dried oil crop are ground, obtains pulverous oil crop；Putting in supercritical equipment, pass into the carbon dioxide of 50MPa, flow is 15L/min, and extraction temperature is 40 DEG C, and after extracting 2.5h, adjustment separating pressure is 12MPa, is separated to vegetable oil.
Embodiment 3: take sanicula lamelligera Hance 20g, August explodes 25g, Herba Maianthemi Bifolii 18g, Radix Cryptolepis sinensis 10g, Radix Glycyrrhizae 6g medical material mixes, boiling twice, 10 times amount into medical material weight that add water, decoct 2h, add water 8 times amount into medical material weight for the second time, decoct 1h, collecting decoction, filter, filtrate is concentrated into relative density 1.15 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stirring, stand 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum of relative density 1.25 (65 DEG C), it is spray-dried that (condition is inlet temperature is 120 DEG C, leaving air temp is 90 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5/s.), it is ground into dry extract, adds vegetable oil prepared by above-described embodiment 1 method, obtain vegetable oil health product soft capsule finished product.
Embodiment 4: take sanicula lamelligera Hance 20g, August explodes 25g, Herba Maianthemi Bifolii 18g, Radix Cryptolepis sinensis 10g, Radix Glycyrrhizae 6g medical material mixes, boiling twice, add water 10 times amount into medical material weight for the first time, decoct 1.5h, add water 8 times amount into medical material weight for the second time, decoct 1.5h, collecting decoction, filter, filtrate is concentrated into relative density 1.15 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stirring, stand 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum of relative density 1.25 (65 DEG C), it is spray-dried that (condition is inlet temperature is 120 DEG C, leaving air temp is 90 DEG C, temperature of charge is 90 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 7.5/s.), it is ground into dry extract, adds vegetable oil prepared by above-described embodiment 2 method, obtain vegetable oil health product soft capsule finished product.
Embodiment 5: improve the pharmacodynamic study of anoxia endurance
Laboratory animal: Kunming mouse, male, body weight 18-22g, Shanghai Slac Experimental Animal Co., Ltd. provides, production licence: SCXK (Shanghai) 2007-0005.
Experimental agents: the vegetable oil health product soft capsule prepared by above-described embodiment 3 preparation method.
Dosage: mouse stomach, then press Mice Body restatement, low dosage, middle dosage and high dose respectively 20g crude drug amount/kg, 40g crude drug amount/kg and 80g crude drug amount/kg.
Positive drug gold day board heart source cellulose capsule, Xiamen Goldensun Technology Co., Ltd., hygienic food and health number (1999) the 0249th, lot number: 20110423.Specification: every dress 0.5g.Patient uses generally each 2, every day 2 times, i.e. people's consumption per day 2g, and being equivalent to every 20g mice consumption is 2*0.0026=0.0052g, calculates by per kilogram mice, and namely positive drug group gives gold day board heart source cellulose capsule 0.26g/kg.
Instrument and reagent: 250mL ground wide mouthed bottle, operating scissors, 1mL syringe, stopwatch, vaseline, sodica calx.
Oxygen deficit tolerance is tested: select healthy mice 50, separate 10 at random and be only used as normal group, all the other 40 mices, it is randomly divided into 4 groups: high dose group, middle dosage group, low dose group, positive drug gold day board heart source cellulose capsule group, wherein 3 dosage groups, gold day board heart source cellulose capsule groups are by above-mentioned dosage gastric infusion, normal group is to the water of 0.2ml, every morning 1 time, continuous 30d, after last gives experiment tested material 1 hour, mice is respectively put in the 250mL ground wide mouthed bottle filling 5g sodica calx (every bottle of mice)；Smear bottleneck with vaseline, cover tightly, so as to air tight；The immediate record time, with respiratory arrest for index, record mice is the death time because of anoxia.
The present invention impact ((X scholar D) on the mice normobaric hypoxia time-to-live
* p < 0.05 is compared with normal group；* compares p < 0.01 with normal group
The normobaric hypoxia time-to-live of of the present invention group of mice is considerably longer than normal group, and has significant difference, illustrates that the present invention has raising anoxia endurance, and compared with positive drug, the time-to-live is long, illustrates that improving anoxia endurance effect is better than positive drug.
Claims (6)
1. the preparation method of a vegetable oil, it is characterised in that oil crop Semen Brassicae campestris or Semen Sesami are carried out parch, obtains dried oil crop；Described dried oil crop are ground, obtains pulverous oil crop；Putting in supercritical equipment, pass into the carbon dioxide of 50MPa, flow is 15L/min, and extraction temperature is 40 DEG C, and after extracting 2.5h, adjustment separating pressure is 12MPa, is separated to vegetable oil.
2. the health product improving anoxia endurance, its contained active component is prepared from by following raw materials in part by weight proportioning: vegetable oil 5 parts, sanicula lamelligera Hance 20 parts, fried 25 parts of August, Herba Maianthemi Bifolii 18 parts, Radix Cryptolepis sinensis 10 parts, 6 parts of Radix Glycyrrhizae, and the method preparation that vegetable oil is the claims 1 obtains.
3. improve the health product of anoxia endurance as claimed in claim 4, it is characterized in that, preparation method step is: take above-mentioned other medical materials merging except vegetable oil, boiling twice, collecting decoction, being concentrated into relative density when 65 DEG C is 1.10-1.20, adds ethanol, stirring, alcohol content by volume percentage calculation is made to reach 65-85%, standing, filter, when filtrate reduced in volume is to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, by concentrated solution spray drying, gained granular powder is broken into dry extract, adds vegetable oil, makes soft capsule.
4. improving the health product of anoxia endurance as claimed in claim 3, it is characterised in that in preparation method, decocting condition is: first time amount of water is the 8-12 times amount of medical material weight, decoct 1-2h, second time amount of water is the 6-10 times amount of medical material weight, decocts 1-2h.
5. improve the health product of anoxia endurance as claimed in claim 3, it is characterised in that in preparation method, spray drying condition is: inlet temperature is 90-110 DEG C, leaving air temp is 60-90 DEG C, temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
6. the health product of raising anoxia endurance application in improving anoxia endurance health product as claimed in claim 2.
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