CN105764543A - Ambulatory infusion system including a step switching mechanism for valve control - Google Patents
Ambulatory infusion system including a step switching mechanism for valve control Download PDFInfo
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- CN105764543A CN105764543A CN201480066363.3A CN201480066363A CN105764543A CN 105764543 A CN105764543 A CN 105764543A CN 201480066363 A CN201480066363 A CN 201480066363A CN 105764543 A CN105764543 A CN 105764543A
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- valve
- valve actuator
- unit
- pump
- administration unit
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1413—Modular systems comprising interconnecting elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14212—Pumping with an aspiration and an expulsion action
- A61M5/14216—Reciprocating piston type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16804—Flow controllers
- A61M5/16809—Flow controllers by repeated filling and emptying of an intermediate volume
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M2005/14573—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for quick connection/disconnection with a driving system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M2039/226—Spindles or actuating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
Abstract
The present disclosure is directed towards a dosing unit (100) for an ambulatory infusion system, including: a metering pump unit (110), the pump unit including a dosing cylinder (112) and a piston (111), the piston (111) being arranged in sealing sliding engagement inside the dosing cylinder (112); a valve unit (120), the valve unit (120) having a filling port (127b), the filling port being designed for fluidic coupling with a liquid drug reservoir (300), a draining port (127c), the draining port (127c) being designed for fluidic coupling with an infusion site interface (890), and a shut-off body (126), the shut-off body (126) being movable between a filling position where it fluidic couples the filling port (127b) with the dosing cylinder (112) and an alternative draining position where it fluidic couples the dosing cylinder (112) with the draining port (127c); a valve driver coupler (125), the valve driver coupler (125) being coupled to or integral with the shut-off body and being the output element of a step switching mechanism. The disclosure is further directed towards a drive unit that may be used in combination with a disclosed dosing unit, an ambulatory infusion system and a method for coupling a dosing unit and a drive unit.
Description
Technical field
The disclosure belongs to the field of the administration unit for portable infusion system.The disclosure still belongs to the field of the driver element for being used in combination with administration unit and enters the field of the portable infusion system of patient body for infusion liquid medicine within the time cycle extended.Additionally, the disclosure belongs to the field of the method for coupling administration unit and driver element.
Background technology
Portable infusion device is well known in the art, such as at the treating diabetes by continuous subcutancous insulin infusion (CSII) and in pain therapy or treatment of cancer, and can obtain from many suppliers, such as Roche Diagnostics GmbH (the Roche Diagnostics of Germany
GmbH, Germany) or Medtronic Inc. (Medtronic MiniMed of California, USA
Inc., CA, USA.).
According to design that is classical and that accepted extensively, these portable infusion devices or system are typically syringe-type of driver.Many shortcomings of this device are well known in the present art.Specifically, they have limited precision because they relate to transferring out from the medicine box of the total injection volume in the range of there is milliliter generally nanoliter in the range of the least medication amount.Therefore, other principle and framework have been proposed that and use special administration unit from the downstream of medicament reservoir, and this administration unit includes, such as, and mocromembrane pump or micro-piston pump, and be adapted for couple to medicament reservoir and be particularly intended for the accurate measurement of small size.Although being well known in the art for several designs of this administration unit, but they being considerably complicated, in them, great majority are relative to being expensive and/or critical on a large scale.
EP1970677A1 discloses a kind of system with miniaturization metering piston pump, it has to cartridge case, should repeat be attached to bigger bin and filled from it to cartridge case, make subsequently to be connected to infusion site to cartridge case, and go out liquid medicine to cartridge case infusion in the time cycle of progressive step and prolongation.In order to make alternately to be connected to bin and infusion site to cartridge case, it is proposed that valve system.
Summary of the invention
EP2163273A1 discloses a kind of administration unit of the principle established according to EP1970677A1.Open according to this, administration unit (the most releasedly) is connected to single driver element, and this driver element is used for piston movement and threshold switch according to plunger position.Threshold switch is by making realizing to cartridge case of described administration unit relative to fixing valve member motion (as rotated), thus sets up the alternately fluid communication arbitrary with import or export to cartridge case.
The overall purpose of the disclosure is to provide a kind of for for the portable infusion system being operated alone of piston displacement and threshold switch and the alternative design of parts thereof.This purpose is that the theme by independent claims realizes.Specific exemplary embodiment is limited by corresponding dependent claims and the embodiment that describes in the present description and drawings.
According to the disclosure, the administration unit for portable infusion system can include dosing pump unit and valve cell.Valve cell can have fill port and discharge port, and described fill port is designed to couple with liquid medicine bin fluid, and described discharge port is designed to couple with infusion site interface fluid.Described valve cell may also include shutoff valve (shut-off) body, described shutoff valve body can move between drain position at filling position and alternately, in filling position, it makes coupling to cartridge case fluid of described fill port and described pump unit, and in drain position, it makes coupling to cartridge case of described pump unit with described discharge port fluid.Described administration unit can farther include valve actuator shaft coupling, and described valve actuator shaft coupling is connected to described shutoff valve body or is one with it, and as stepping switch mechanism (step
Switching mechanism) output element.
For the operation of administration unit, valve actuator is operably linked to valve actuator, valve actuator and valve actuator shaft coupling via valve actuator and forms stepping switch mechanism in combination.As following under the background of exemplary embodiment with will be discussed in greater detail, make described valve cell couple with attachment valve actuator via stepping switch mechanism and confirm many advantages.Specifically, it allows valve transmission to use relatively low required precision to operate.Additionally, for the simple and convenient assembly or disassembly of modular infusion system, it is favourable.
Pump unit can be specifically designed to the miniaturization piston pump of cartridge case and piston, and this piston is arranged to sealing and is slidably engaged on described to cartridge interior, such as in the hole extended along the described central axis to cartridge case (i.e. with cylinder axis coaxle).It should be noted that term " hole " (in herein and below) does not implies that any restriction relative to manufacturing process.Described can be as other parts of described administration unit to cartridge case, such as, print by machining, injection-molded, 3D or can manufacture with other manufacturing technology used by the way of alone or in combination.
The measuring room limiting variable-volume to cartridge case and piston in the way of syringe-like in combination, wherein this volume is limited by cross-sectional area and the piston position in hole.Between measuring room with valve cell, there is fluid couple, thus fluid couples and enters measuring room for pumping liquid medicine via valve cell to cartridge case and valve cell, and be alternately transferred out liquid medicine from measuring room.Piston can move between farthest side position and recent side position, and wherein farthest side position is corresponding to the maximum volume of measuring room, and recent side position is corresponding to the minimum and the most insignificant volume of measuring room.The volume of measuring room is also referred to as to the packing volume of cartridge case.In an exemplary embodiment, it can be used for such as in CSII field, and maximum packing volume can be such as in the range of 10 μ l to 200 μ l, corresponding to 1 to 20 units of liquid U100 insulin preparation.In certain embodiments, maximum packing volume is in the range of 50 μ l to 100 μ l, such as 60 μ l.The diameter in hole can cause piston displacement in the range of several millimeters to several centimeters in the range of several millimeters.
As will be detailed below being discussed further, piston can be connected to pump drive for the shift reciprocately in incremental or virtually limitless step, thus allows packing volume change in incremental or virtually limitless step.
Designing according to specific valve, shutoff valve body can have multiple design.In an exemplary embodiment, it is the axially symmetric body with the some radially and/or axially fluid passages for controlling flow.Advantageously there are at least one position in shutoff valve body, the particularly centre position between filling position and drain position, in this position, pump port had both been not coupled to fill port and had also been not coupled to discharge port and measuring room correspondingly fluid isolation.
In certain embodiments, valve actuator shaft coupling includes pocket-wheel or pocket-wheel part, sheave or sheave portions (Geneva-type
Wheel section).As by described by under the background of exemplary embodiment below, sheave can serve as being particularly suitable for the output element of the switching mechanism design of the application.It is also possible, however, to use other type of stepping switch mechanism.
In certain embodiments, shutoff valve body design is general cylindrical body.Cylinder body can exemplarily have a diameter of 3 millimeters or less, such as 1.5 millimeters.In modification, diameter can change the most along its length or continuously, and the latter produces the shutoff valve body of taper.Valve and the small size of especially shutoff valve body be favourable due to multiple reasons, such as minimize dead volume and the overall dimension of fluid.
In certain embodiments, shutoff valve body is made up of hard material, specifically, is made up of rigid plastics, and the shutoff valve body contact surface of valve chest is made up of soft material, specifically, is made up of thermoplastic elastic body.It is used as other flexible plastic.This type of design is favourable for sealing.
In certain embodiments, shutoff valve body design becomes around valve rotation axis rotatable movement.For the embodiment of this type, valve cell is designed as rotary valve, and wherein valve state is determined relative to the position of rotation of valve chest by shutoff valve body.Embodiment for this type, filling position and drain position are the position of rotation of the shutoff valve body that the fluid passage of foregoing shutoff valve body is directed at fill port or discharge port respectively, wherein fill port and get rid of the hole that port is implemented as in valve chest.Alternatively, however, valve cell can be realized in a different manner, such as, it is achieved become there is the slide-valve of linear slide shutoff valve body, or in the way of rotary motion with the combination of sliding motion.
In certain embodiments, valve rotation axis is parallel or perpendicular to the piston displacement axis of pump unit.The design of the particularly compact and user friendly design of arbitrary permission in those designs that will illustrate in greater detail further the most below.
In certain embodiments, valve actuator shaft coupling includes engaging groove, and it is for engaging with the engaging pin of the valve actuator driving element as stepping switch mechanism.
In certain embodiments, administration unit is designed to couple releasedly with driver element.The releasable of administration unit and driver element couples the design allowing modular portable infusion system, the design of this modular portable infusion system such as with include driver element with and the durable unit of user interface, control circuit etc. can be included and be designed to such as the single application of the most several days and administration unit and the disposable unit of liquid medicine bin can be included.For this type of modularized design, presented below go out, be particularly advantageous via stepping switch mechanism control valve for coupling and releasing connection, will be discussed the most further.Alternatively, however, administration unit can completely or partially with driver element global formation.
Term " releasably couples " design correspondingly referring to allow administration unit and the mechanical attachment of driver element and releasing to couple, it is shown greatly substantially rigid mechanical attachment and additionally is able to release subsequently the form of connection, wherein releases connection and at least driver element is not resulted in infringement.For this purpose it is proposed, corresponding mechanical erection structure may be provided at administration unit and driver element, further described below.Administration unit is to the position of the mechanical attachment simultaneously the most advantageously piston driving of attachment valve unit (especially, valve actuator shaft coupling) and the valve transmission of administration unit and administration unit of driver element.
According to other aspect, the disclosure is for driver element.Driver element can include pump drive (pump drive), described pump drive includes pump actuator and is connected to the pump driver of described pump actuator, described pump driver is designed for being connected to the piston of dosing pump unit, for the piston by being transferred to pump unit from the pump activation force of pump actuator and/or pump driving torque.Driver element may further include valve transmission, described valve transmission includes valve actuator and is connected to the valve actuator of described valve actuator, described valve actuator is designed for being connected to the valve actuator shaft coupling of valve cell, for threshold switch active force and/or the threshold switch torque from valve actuator is transferred to valve cell, wherein valve actuator is the driving element of stepping switch mechanism.
In certain embodiments, valve actuator includes the engaging pin for engaging with valve actuator shaft coupling.Described engaging pin is off on valve actuator body.Valve actuator can farther include the centrepin being directed at valve gear output shaft.In operation, engaging pin correspondingly moves on circular path around centrepin.
In certain embodiments, driver element is designed for coupling releasedly with administration unit." releasably " be understood as with in the context of administration unit before described identical implication.
According to aspect still further, it relates to enter the portable infusion system of patient body for infusion liquid medicine within the time cycle extended.Infusion system can include as under the background of exemplary embodiment before and further below substantially described in administration unit and driver element.
In some embodiments of portable infusion system, when administration unit couples with driver element, valve actuator and valve actuator shaft coupling are in non-engagement state.For the embodiment of this type, the engagement of valve actuator and valve actuator shaft coupling only occurs under such state, i.e. after coupling motion, the mechanical attachment between driver element and administration unit has built up.Thus, reduce to a great extent for setting up the precision coupled and to alignment request.
According to aspect still further, it relates to for coupling the method for administration unit and the method for driver element, as under the background of exemplary embodiment before and further below substantially described in.Described method can include being provided as driver element with administration unit the unit that structure is different.Described method can farther include to implement to couple motion, described connection campaign causes driver element to enter exercisable relative position with dosing pump unit, described connection motion causes valve actuator and valve actuator shaft coupling to enter exercisable relative position further, wherein, valve actuator and valve actuator shaft coupling are in non-engaged configuration during coupling motion.
Accompanying drawing explanation
Hereinafter, exemplary embodiment is discussed in more detail referring additionally to accompanying drawing.
It is to be noted that, in the following description, the term of direction indication, position or orientation, as "left", "right", " upper and lower ", " top ", " end " are intended only to facilitate the understanding of reader and only refer to accompanying drawing.It is not intended to imply that for any specific direction of the application or orientation.
Fig. 1 shows the critical piece according to portable infusion system disclosed by the invention with the function view simplified.
Fig. 2 shows the exemplary embodiment of the administration unit that the exemplary embodiment with driver element is combined.
Fig. 3 a, 3b illustrate in perspective view the exemplary shutoff valve body being attached with valve actuator shaft coupling.
Fig. 4 a, Fig. 4 b, Fig. 4 c show the operation of the Geneva mechanism of the exemplary embodiment as stepping switch mechanism.
Fig. 5 a, 5b show the internal structure of a part for example valve unit and example pump unit, and show their operation.
Fig. 6 a, 6b show illustrative portable infusion system.
Fig. 7 a, 7b show the internal structure of a part for other example valve unit and other example pump unit, and show their operation.
Fig. 8 shows other exemplary slot wheel mechanism.
Detailed description of the invention
Fig. 1 shows administration unit 100 and driver element 200, and liquid medicine bin 300.In the present invention, those especially relevant 26S Proteasome Structure and Function unit are disclosed it should be noted that, illustrate only.It is also typically present other unit such as such as electronic control unit, power supply, user interface.
Administration unit 100 includes dosing pump unit 110, be included in general introduction have as above hole and the piston element of label (individually) to cartridge case.To in the nearside antetheca of cartridge case, hole is arranged to couple to the fluid port of pump port 127a.Administration unit also includes alternately being in occupied state 120b or the valve cell of state 120a of discharge.During operation, valve cell repeats switching between these states.Bin 300 is fluidly coupled to valve cell via the fill port 127b of valve cell.Patient 900 is fluidly coupled to valve cell via fill port 127c, infusion site interface 890.It is noted that infusion site interface 890 is exemplarily illustrated as with infusion line (such as, conduit) integrally.Administration unit 100 also includes valve actuator shaft coupling 125, and it is used for making valve cell switch between filling position 120b and drain position 120a.Similarly, administration unit 100 includes pump driver shaft coupling 115, and it is for making the piston of pump unit 110 move to cartridge case inner linear.
Relative to valve cell, being further noted that, Fig. 1 illustrate only and arbitrary in fill port 127b or discharge port 127c is connected to state 120a of pump port 127a, 120b.But in other intermediateness, all three port 127a, 127b, 127c are turned off, produce fluid isolation.
Driver element 200 includes the pump drive 217 being connected to pump driver shaft coupling 215 and is connected to the valve transmission 227 of valve actuator shaft coupling 215.
Hereinafter, referring additionally to Fig. 2, it illustrates exemplary administration unit 100 and corresponding exemplary driver unit 200, administration unit 100 and driver element 200 belong to the part of the portable infusion system according to Fig. 1.Actuator unit 200 is usually designed to long-life or durable module.Other parts of similar portable infusion system, such as user interface and control circuit may be designed as having the service life that some months was by several years.Administration unit 100 is usually designed to be intended for single use module, and it uses the most continuously and to (such as) 2 weeks and is dropped subsequently for several days.Due to their different application time, administration unit 100 and driver element 200 are designed to releasable mechanism as previously described and exercisable connection.Administration unit mounting structure 195 and driver element mounting structure 295 are respectively equipped with for mechanical attachment or installation, administration unit 100 and driver element 200.Exemplarily, administration unit mounting structure 195 is implemented as the elongated convex structure with T section, and driver element mounting structure 295 is implemented as the elongated concave structure accordingly with T section.This structure is designed with small-gap suture (alternatively, biasing) and is slidably engaged.Alternatively, it is possible to provide other locking member (not shown).In order to couple administration unit 100 and driver element 200, administration unit 100 is moved on the direction contrary with arrow A linearly relative to driver element 200 so that mounting structure 195,295 engages.Release to couple and implemented by the motion of corresponding linear inverse.In a further embodiment, mechanical attachment can keep via snap fit clip, via magnetic couplings etc., as by described by under the background in another following embodiment.
Hereinafter referred to as " nearside ", the direction contrary with arrow A is referred to as " distally " in the direction indicated by arrow A.
The pump unit 110 of administration unit 100 and valve cell 120 are illustratively embodied as wherein piston displacement axis and valve rotation axis coincident and are parallel to the conllinear design of arrow A, produce the elongated global shape of administration unit 100.Valve cell 120 is arranged to the shape close with pump unit 110.Both internal structures and the operation of administration unit 100 are described further below referring additionally to other accompanying drawing.
In the proximal end of valve cell 120, valve actuator shaft coupling 125 is arranged to rotate around valve rotation axis.Valve actuator shaft coupling 125 is illustratively embodied as the sheave portions with three sectors.
Driver element 200 includes pump drive 217 and valve transmission 227.Pump drive 217 includes pump actuator 217a and pump gear 217b, and valve transmission 227 includes valve actuator 227a and valve gear 227b.Two pump drives 217 and valve transmission 227 are all designed for reciprocating operation.
Pump actuator 217a and valve actuator 227a both of which are illustratively embodied as the motor of routine.But any one can also realize, such as direct current generator, brshless DC motor or the specially designed electromagnetic driver of standard by different modes in both.Optional sensor can be there is for controlling and/or the purpose of feedback, but not necessarily.For example, it is possible to provide optional sensor for detecting piston to the proximal location within the hole of cartridge case and remote location, it is corresponding to the minimum and maximum packing volume of cartridge case and/or linear position sensor can be provided to be used for substantially continuous detect piston.Similarly, such as the sensor of contact or noncontact end switch can exist whether to detect the shutoff valve body of valve cell 110 respectively at filling position or drain position.
Pump gear 217b is designed as combining the reduction gearing of the conventional spur gear form of main shaft drives and plunger 217c, thus the rotary motion of the output shaft of pump actuator 217a is converted into the plunger 217 corresponding linear displacement motion on the direction being parallel to arrow A.In the coupled situation of administration unit and driver element, the axis of plunger 217c with to the hole of cartridge case and piston displacement axis coaxle.In pump driver 215(Fig. 2 invisible) be attached to plunger 217c or become its a part, it is designed to couple releasedly with pump driver shaft coupling, this pump driver shaft coupling be rigidly connected to pump unit 110 piston (invisible in Fig. 2) or with its one.Pump driver 215 and pump driver coupling design are that push-pull type couples, and such as bayonet type connection, be clasped connection etc..The reciprocating motion of plunger 217c causes the corresponding reciprocating-piston on nearside or distal direction to move the most respectively.
Valve gear 277b is reduction gearing, and it is embodied as with being connected to the output shaft of valve gear 227b or the conventional gear of the valve actuator 225 with its one.For stepping switch mechanism and the following design of valve cell, such as, can be level Four spur gear by valve design of gears.It should be noted, however, that for pump gear 217b and valve gear 227b, it is possible to use alternatively design, such as, can use planetary gear, worm-gear toothing, sprocket or other type of Traction Drive.
The most separately below with reference to Fig. 3 and Fig. 4.Fig. 3 a, Fig. 3 b shows two perspective views of the shutoff valve body 126 of the valve cell 120 together with valve actuator shaft coupling 125, and shutoff valve body 126 and valve actuator shaft coupling 125 are rigidly connected or with integral manner molding.Shutoff valve body 126 has the shape of general cylindrical shape, and is designed for sealing with rotational slide reception in the corresponding hole of valve chest.Shutoff valve body 126 has central fluid channel 126a, and it is implemented as bolt hole and the longitudinal axis along shutoff valve body 126 extends.The outlet of central fluid channel 126a is used as pump port 127a.Shutoff valve body 126 also includes vertical and with central passage 126a fluid communication two radial passages 126b, 126c.As will be described in further detail below, radial passage 126b, 126c are fluidly connected to fill port 127b and discharge port 127c.Exemplarily, radial passage 126b, 126c arranges relative angle in 90 °.It is used as other angle.
Valve actuator shaft coupling 125 is designed to sheave portions.In a particular embodiment, corresponding full sheave will have eight sections around its circumference equal distribution, and indeed achieves three section 125a for valve actuator shaft coupling 125.Single section 125a includes the circular side face 125b and sagittal plane 125d of spill.Circular side face 125b and sagittal plane 125d connects via little middle side face (unmarked).Sagittal plane 125d forms engaging groove 125c radially between adjacent section 125a.
Fig. 4 shows the interaction designing and illustrating between stepping switch mechanism of valve actuator 225, and it is realized by valve actuator 225 and valve actuator shaft coupling 125 combination.Valve actuator 225 includes body 225a, centrepin 225b and eccentric engaging pin 225c, and the single parts of valve actuator 225 are rigidly attached or molding in a unitary manner.Valve actuator 225 is rigidly coupled to the output shaft of valve gear 227b so that centrepin 225b and output shaft are coaxial, thus when output shaft rotates, valve actuator body 225a and engaging pin 225c rotates around centrepin 225b.As seen from Figure 4, centrepin 225b actually wherein has and points to the pin part that the section of engaging pin 225c is cut.The diameter of centrepin 225b is corresponding to the diameter of circular side face 125, and the diameter of engaging pin 225c is corresponding to the width of engaging groove 125c, slidably engage so that being formed between engaging pin 225c with engaging groove 125c and between centrepin 225a and circular side face 125b substantially free of rotation (play-free).
Fig. 4 a is shown in which that valve cell 120 is in the configuration of filling position.In this state, centrepin 225b and circular side face 225b is in slide to rotate and engages.As long as engaging pin 225c does not engages with engaging groove 125c, then the most therefore any rotation and especially holding shaft 225b of valve actuator 225 cause any motion of valve actuator shaft coupling 125.Via joint, valve actuator 125 is kept and is locked in its position.
In order to the operation of stepping switch mechanism is described, it is assumed that valve actuator 225 turns clockwise, as shown in arrow corresponding in Fig. 4 a, 4b, 4c.Fig. 4 a shows that engaging pin 225c and engaging groove 125c reaches to engage the moment engaged.Further rotating of valve actuator 225 causes engaging pin 225c radially-inwardly to advance in engaging groove 125c, and via the sliding engagement with cell wall, makes valve actuator shaft coupling 125 rotate in the counterclockwise direction together with shutoff valve body 126.
Fig. 4 b shows that engaging pin 225c is in the configuration of its radially inner most position in engaging groove 125c.The radial outward movement of the engaging pin 225c caused in engaging groove 125c and the most counterclockwise of valve actuator shaft coupling 125 are rotated by turning clockwise further of valve actuator 225, to the last engaging pin 225c leaves engaging groove 125c, thus terminates to engage joint between engaging pin 225c with engaging groove 125c.Fig. 4 c shows that engaging pin 225c and engaging groove 125c is disengaged from the configuration engaged the most subsequently.
It can be seen that at least one in all time points with centrepin 225b or engaging pin 225c of the sheave of valve actuator 125 is in joint from Fig. 4 a, 4b, 4c.When engaging pin 225b is in and engages the position engaged with engaging groove 125c, rotating via positive orientation guide by being controlled with the interaction of engaging pin 225c of valve actuator shaft coupling 225.When engaging pin 225c is in not with the position of the interaction of engaging groove 125c, valve actuator shaft coupling 125 is locked into position via the joint of centrepin 225b with circular side face 125b.
Configuration shown in Fig. 4 c is neutral configuration, in this configuration, valve cell had both been not at filling position not also in drain position, but there is not, with between arbitrary in fill port 127a or discharge port 127c, both centres that fluid couples respectively at pump port 127a.Turning clockwise further of plunger actuator 225 will cause repetition aforementioned sequence, wherein differs only in another engagement in engaging pin 225c and two groove 125c.When engaging pin 225c and the second engaging groove 125c is disengaged from engaging, valve cell 110 is in drain position.The most complete rotation of valve actuator 225 correspondingly causes the rotation of valve actuator shaft coupling 125, and it corresponds respectively to the angle between adjacent sheave type section 125a or engaging groove 125c.
Exemplary design for shutoff valve body as shown in Figure 3, the order that engagement continuously between engaging pin 225c and two engaging groove 125c engages and is disengaged from engaging causes valve actuator shaft coupling 125 and shutoff valve body 126 half-twist altogether, and it corresponds respectively to the angle between radial passage 126b, 126c.In modification, valve actuator shaft coupling 125 can have more or less of section 125a, and the switching between filling position and drain position can be via more than one intermediate steps or do not have any intermediate steps to realize, as long as total angle is corresponding to according to the switch angle needed for shutoff valve body design.For the modular design of Miniaturized portable infusion system, shown exemplary design is considered as the good compromise considering the such as factor of friction (and thereby taking into account the design of energy expenditure and valve actuator), valve gear reduction ratio and overall dimensions.
It is to be realized by the similar fashion rotated counterclockwise with valve actuator 225 that the state of switching valve cell is back to filling position.
Advantageously, it is provided with two pairs of retainers (not being shown respectively), it limits the rotary motion between valve actuator shaft coupling 125 and shutoff valve body 126 relative to valve chest, when shutoff valve body is respectively at filling position or drain position, this type of further motion of valve actuator shaft coupling 125 and shutoff valve body 126 is prevented from.Therefore, rotary motion is limited to the angular range between filling position and drain position respectively.
The design of retainer is included for this type of, when such as motor is used as valve actuator, it is possible to achieve simply and effectively control.Owing to the motion further of valve actuator shaft coupling 125 and shutoff valve body 126 is impossible, so when reaching filling position or drainage position, activating further of motor will cause detectable stepping to lose.In this way, it is possible to detection filling position and drain position are without extra sensor.
In the description and be previously given from Fig. 4 a to 4c, stepping switch mechanism is used to be made apparent from de for the major advantage of threshold switch.
As it was previously stated, when engaging pin 225c does not engages any engaging groove 125c, for all position of rotation of valve actuator 225, restriction well and lock-up valve driver shaft coupling 125 and the position of rotation of corresponding shutoff valve body 126.The independence of this effective holding valve actuator 225 and the especially specific orientation of engaging pin 225c.This is in the diagram by the situation in region represented by letter " B ", corresponding to the anglec of rotation of about 180 °, the half that i.e. valve actuator 225 is fully rotating.When switching between filling position and drain position respectively, as long as the complete sequence being engaged and disengaged from guaranteed between engaging pin 225c and engaging groove 125, then valve actuator 225 starts its motion and therefore eventually stop at which position of rotation after handover be inessential at which definite position of rotation.Therefore, the required precision for valve actuator and control thereof significantly reduces.
Stepping switch mechanism is also advantageous relative to the connection of administration unit 100 and driver element 200.Foregoing, this process is by not having special mechanical ability and having user's (such as diabetics) of the dyskinesia and/or visual disorder in many cases and implement on a regular basis.As long as engaging pin 225c is in disengaged condition, then unique between valve actuator 225 with valve actuator shaft coupling 125 couples is to be provided by the sliding engagement between centrepin 225b and circle side face 125b.Therefore, coupling between administration unit mounting structure 195 and driver element mounting structure 295 and engage and can be set up relative to the simple translational motion of driver element 200 by administration unit 100, specific orientation or position of rotation without valve actuator 225 are set up.By in this way administration unit 100 being connected to driver element 200, automatically set up correct operating position, and thus automatically set up valve actuator 225 and couple with the operable of valve actuator shaft coupling 125.
By keeping the alternative connection form (such as valve actuator and a pair spur gear of valve actuator shaft coupling and valve transmission) coupled to compare with via angle, it is possible to be best understood by the aforementioned advantages of stepping switch mechanism.This type of couples the accurate relative orientation needing connection element.Via the connection of gear, such as spur gear, such as, the tooth of in gear and the backlash of other wheel alignment is needed correct to engage joint to set up.
Favorable property for driving stepping switch mechanism that valve moves is closely related with the big volume property of the stepping switch mechanism being suitable for, drive or input element (valve actuator) and driven or output element (valve actuator shaft coupling) be in engagement engage only be temporarily used for switch and drive or input element complete rotation a part on, and be otherwise disengaged.Common angle for such as spur gear keeps gear just contrary, drives or input element is in driven or output element and engages joint continuously.Therefore, as, in the broad variety of (such as) clockwork and wrist-watch, in film camera and projector, changed the other type of stepping switch mechanism used in mechanism at the pen of chemistry/medical analysis instrument or drawing apparatus and may be adapted to the purpose of Vavle switching equally.
The characteristic of stepping switch mechanism with need not to position specially alternative couple compared be also advantageous, such as compared with coupling with via the friction of a pair friction pulley, wherein friction pulley is typically crucial and such as reduces and be therefore subjected to fault owing to producing and coupling the friction unintentionally of tolerance, lubricant and abrasion.
But, making administration unit 100 and driver element 200 couple in the foregoing manner needs the position of rotation of valve actuator shaft coupling 125, and in this position of rotation, arbitrary circular side face 125b is coaxially aligned with centrepin 225b.For shown embodiment, in filling position and drainage position, (one of them is shown in fig .4) respectively and centre position shown in Fig. 4 c meets this requirement.For assembling, no matter shutoff valve body is in filling position or drain position, and both of which can be limited well by foregoing retainer.Owing to administration unit is typically the aseptic disposable product that is used continuously some skies and is dropped subsequently, administration unit 100 is only implemented once to couple.Therefore, it can administration unit be provided in limited be in filling position and exhaust position by producer.
The internal structure of administration unit 100, especially pump unit 110 and valve cell 120 and its operation is received below referring additionally to Fig. 5 a, 5b, each of which illustrates the sectional view of a part for pump 110, as from the top of Fig. 2 with seen by the intersecting plane of axis of symmetry (piston displacement axis and valve rotation axis).Fig. 5 a illustrates occupied state (valve body 126 is at filling position), and Fig. 5 b illustrates discharge state (valve body 126 is at drain position).But for the exemplary design of administration unit 100, it must further be noted that, occupied state and discharge state are fluid equivalences and therefore can exchange.
As visible from Fig. 5 a, 5b, exemplarily there is the central through hole changing diameter along its center axis to cartridge case 112, and have valve chest 127 and be sealingly disposed in the distal part in hole, and piston 111 seals and is slidably arranged on from valve chest 127 nearside of hole.During assembly, valve cell is correspondingly distally received by centre bore and piston 111 is received by centre bore from the nearside to cartridge case 112.The nearside front surface of piston 111 and the distal anterior surface of valve chest 127 the most correspondingly limit the distally and proximally limiting surface of measuring room 113, and pump port 127a is a part for nearside limiting surface.
As visible from Fig. 5 a, in occupied state, radial passage 126b is directed at fill port 127b, and as discharge port 127c, this fill port is formed by the radial fluid passages in valve chest 127 or hole.In this state, fill port 127b correspondingly couples with central passage 126a fluid.Not corresponding with valve chest 127 fluid passage of other radial passage 126c or hole alignment, and be thus sealed and closed via with contacting of valve chest 127.
In occupied state, by making piston 111 along piston displacement axis shift in the distal direction contrary with arrow A, correspondingly can fill with liquid medicine to cartridge case 112, thus increase and pumping liquid entrance measuring room 113.During this filling process, valve cell 120 guarantees the fluid isolation of discharge port 127c, and therefore ensures that the fluid isolation of infusion line 890.
In discharge state shown in figure 5b, radial passage 126c is directed at discharge port 127C.In this state, discharge port 127c correspondingly couples with central passage 126a fluid.Other radial passage 126b not with the corresponding fluids channel alignment of valve chest 127, and be thus sealed and closed via with contacting of valve chest 127.
In discharge state, by make piston 111 by the proximal direction indicated by arrow A along piston displacement axis shift, it is possible to correspondingly discharge the liquid in measuring room 113, thus reduce from measuring room 113 and correspondingly drain.During this discharge process, this valve guarantees the fluid isolation at fill port 127b, and therefore ensures that the fluid isolation of medicament reservoir 300.
Fig. 6 a, 6b show the illustrative portable infusion system according to the disclosure.This system includes durable unit 400 and disposable unit 500.The orientation that unit 400,500 both of which is illustrated to be orientated to during applying is corresponding, but is currently in not-connected status, such as, before coupling.Reusable unit 400 realizes relative to the linear movement of disposable unit 500 upwardly through reusable unit 400 with the side indicated by arrow A that is connected in of disposable unit 500.Fig. 6 a and 6b the difference is that only that Fig. 6 a illustrates that both unit 400,500 have external shell or outer housing, and unit 400,500 in figure 6b is shown without housing.
Reusable unit 400 includes driver element and can also include the parts such as such as user interface, control circuit, communication interface.The seam that circumferential seal 403 is located to disposable unit 500 is to guarantee watertightness in the assembled state or waterproofing protection.Alternatively or additionally, sealing member is located at disposable unit 500.In the following description, identical with the element of previous embodiment or corresponding element is appointed as identical reference.
Disposable unit 400 includes administration unit and medicament reservoir, and it can be implemented as substantially flexible bag or bag, such as such as cylinder rigid case, or has rigidity and the soft or semi-rigid construction of flexible member.Can use in conjunction with administration unit as shown in Figure 2 with type medicament reservoir.
The overall architecture of administration portable infusion system and especially administration unit and driver element is corresponding to design as shown in Figure 1.Additionally, this design is corresponding generally to the exemplary design shown in Fig. 2 to Fig. 5.But, realize some aspects in a different manner, as will be described below.
In the embodiment in fig 6, driver element is implemented as only rotating driving, and pump driver 215 is reciprocating rotary rotating shaft.Pump driver 225 has noncircular cross section the most over a part of its length, and this noncircular cross section can be realized by longitudinal concave element (such as, groove) and/or longitudinally projecting element (such as, wedge).The pump driver shaft coupling (not shown) of pump unit have corresponding to drive shaft coupling 225 shape in a rotational direction engage and in a longitudinal direction substantially free of friction or the sliding engagement of low friction.Thus, can use to slide axially and engage and rotate positive lock driving torque is sent to have from pump driver 225 the pump driver shaft coupling in corresponding cross section.Pump driver shaft coupling can be formed by elongated axial member, and it is disposed remotely from sealing piston and points to away from measuring room.Pump driver shaft coupling can with piston be in rigid attachment or with piston one.In order to the rotary motion of pump driver 225 is changed into the linear of piston, or spiral helicine motion, the distal part of cartridge case being provided with screw thread, particularly female thread, its length at least corresponds to the total displacement distance of plunger.Corresponding external screw thread is located at at least one part of pump driver shaft coupling.
Contrary with the embodiment of valve rotation axis coincident with piston displacement axis in Fig. 2 to Fig. 5, valve rotation axis is parallel to arrow A' and is perpendicular to piston displacement axis.Therefore, valve chest 127 is the most correspondingly perpendicular to the axis of cartridge case.
For coupling of reusable unit 400 and disposable unit 500, snap fit clip 405 is located at reusable unit.Snap fit clip 405 is designed as proximal open loop member and the diameter that has to snap into around valve chest 127, and in the present embodiment, this valve chest is used simultaneously as administration unit mounting structure.It should be apparent that, it is possible to use alternative mounting structure, such as corresponding to that structure shown in Fig. 2 and magnetic connection etc..
Corresponding with Fig. 5 a, Fig. 5 b for previous embodiment, according to the internal structure of the administration unit of this exemplary embodiment 100, especially pump unit 110 and valve cell 120 and the operation of administration unit, it is described below referring additionally to Fig. 7 a, 7b.In the embodiment of Fig. 7, shutoff valve body 126 only has two radial passage 126b and 126, but does not has central passage.Radial passage 126b and 126c is designed as through hole, and it is axially displaced along the axis of symmetry of shutoff valve body 126 and arranges exemplary angle in 90 °.Being provided with two pump port 127a, one of them is directed at radial passage 126b in occupied state (Fig. 7 a), and another is directed at radial passage 126c in the state of discharge (Fig. 7 b).Similarly, two corresponding holes (unmarked) are located in 112a before the nearside substantially closed of cartridge case 112, and it is directed at pump port 127a.
Fill port 127b and discharge port 127c are arranged to piston displacement axis in the present embodiment parallel and perpendicular to valve rotation axis.Fill port 127b or discharge port 127c is formed respectively respectively via the straight design fluidly connected of radial passage 126b or 126c to measuring room 113 to this end, give.
Fig. 8 shows the layout of the stepping switch mechanism with valve actuator 225 and valve actuator shaft coupling 115, and it illustrates the state that non-engagement engages.
Reference
| 100 | Administration unit |
| 110 | Pump unit |
| 111 | Piston |
| 112 | To cartridge case |
| 112a | Before nearside |
| 113 | Measuring room |
| 115 | Pump driver shaft coupling |
| 120 | Valve cell |
| 120a | Valve (drain position) |
| 120b | Valve (filling position) |
| 125 | Valve actuator shaft coupling |
| 125a | Sheave type section |
| 125b | Circular side face |
| 125c | Engaging groove |
| 125d | Sagittal plane |
| 126 | Shutoff valve body |
| 126a | Central passage |
| 126b, c | Radial passage |
| 127a | Pump port |
| 127b | Fill port |
| 127c | Discharge port |
| 195 | Administration unit mounting structure |
| 200 | Driver element |
| 215 | Pump driver |
| 217 | Pump drive |
| 217a | Pump actuator |
| 217b | Pump gear |
| 217c | Plunger |
| 225 | Valve actuator |
| 225a | Valve actuator body |
| 225b | Centrepin |
| 225c | Engaging pin |
| 227 | Valve transmission |
| 227a | Valve actuator |
| 227b | Valve gear |
| 295 | Driver element mounting structure |
| 300 | Medicament reservoir |
| 400 | Reusable unit |
| 403 | Sealing member |
| 405 | Snap fit clip |
| 500 | Disposable unit |
| 890 | Infusion line with infusion site interface |
| 900 | Patient |
Claims (14)
1. the administration unit (100) for portable infusion system, including:
-dosing pump unit (110), described pump unit includes to cartridge case (112) and piston (111), and described piston (111) is arranged in described being in cartridge case (112) inside and seals sliding engagement；
-valve cell (120), described valve cell (120) has: fill port (127b), and described fill port is designed to couple with liquid medicine bin (300) fluid；Discharge port (127c), described discharge port (127c) is designed for coupling with infusion site interface (890) fluid；And shutoff valve body (126), described shutoff valve body (126) can be moved between drain position at filling position and alternately, wherein described in described filling position, fill port (127b) couples to cartridge case (112) fluid with described, and couples to described in described drain position cartridge case (112) with described discharge port (127c) fluid；
-valve actuator shaft coupling (125), described valve actuator shaft coupling (125) is connected to described shutoff valve body or is one with described shutoff valve body, and as the output element of stepping switch mechanism.
Administration unit the most according to claim 1 (100), wherein, described valve actuator shaft coupling (125) includes pocket-wheel or pocket-wheel part, sheave or sheave portions.
3. according to administration unit in any one of the preceding claims wherein (100), wherein, described shutoff valve body (126) is designed to general cylindrical body.
4. according to administration unit in any one of the preceding claims wherein (100), wherein, described shutoff valve body (126) is made up of hard material, it is made up of rigid plastics especially, and the shutoff valve body contact surface of valve chest (127) is made up of soft material, it is made up of thermoplastic elastic body especially.
5. according to administration unit in any one of the preceding claims wherein (100), wherein, described shutoff valve body (126) is designed around valve rotation axis rotary motion.
Administration unit the most according to claim 5 (100), wherein, described valve rotation axis is parallel or perpendicular to the piston displacement axis of described pump unit (110).
7. according to administration unit in any one of the preceding claims wherein (100), wherein, described valve actuator shaft coupling (125) includes engaging groove (125c), and described engaging groove (125c) is for engaging with the engaging pin (225c) of the valve actuator (225) driving element as stepping switch mechanism.
Administration unit the most according to claim 7 (100), wherein, described administration unit (100) is designed to couple releasedly with driver element (200).
9. a driver element (200), described driver element (200) including:
-pump drive (217), described pump drive (217) includes pump actuator (217a) and is connected to the pump driver (215) of described pump actuator (217a), and described pump driver (215) is designed to couple to the piston of dosing pump unit (110) so that pump driving force and/or pump driving torque are sent to the piston (111) of described pump unit (110) from described pump actuator (217a)；
-valve transmission (227), described valve transmission (227) includes valve actuator (227a) and is connected to the valve actuator (225) of described valve actuator (227a), described valve actuator (225) is designed to couple to the valve actuator shaft coupling (125) of valve cell (120) so that threshold switch active force and/or threshold switch torque are sent to described valve cell (120) from described valve actuator (227a)
Wherein, described valve actuator (225) is the driving element of stepping switch mechanism.
Driver element the most according to claim 9 (200), wherein, described valve actuator (225) includes the engaging pin (225c) for engaging with described valve actuator shaft coupling (125).
11. according to the driver element (200) described in claim 9 or 10, and wherein, described driver element (200) is designed to couple releasedly with described administration unit (100).
12. 1 kinds enter the portable infusion system of patient body for infusion liquid medicine within the time cycle extended, and described infusion system includes the driver element (200) described in administration unit according to claim 8 (100) and claim 11.
13. portable infusion systems according to claim 12, wherein, when described administration unit (100) couples with described driver element (200), described valve actuator (225) and described valve actuator shaft coupling (125) are in non-engagement state.
14. 1 kinds are used for coupling administration unit according to any one of claim 1 to 8 (100) and the method according to the driver element (200) according to any one of claim 9 to 11, and described method includes:
-described driver element (200) is provided as, with described administration unit (100), the unit that structure is different；
-implement to couple motion, described connection campaign causes described driver element (200) to enter exercisable relative position with dosing pump unit (110), described connection motion causes described valve actuator (225) to enter exercisable relative position with described valve actuator shaft coupling (125) further, wherein, described valve actuator (225) and described valve actuator shaft coupling (125) are in non-engaged configuration during coupling motion.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13195599.9A EP2881128B1 (en) | 2013-12-04 | 2013-12-04 | Ambulatory infusion system including a step switching mechanism for valve control |
| EP13195599.9 | 2013-12-04 | ||
| PCT/EP2014/075826 WO2015082305A1 (en) | 2013-12-04 | 2014-11-27 | Ambulatory infusion system including a step switching mechanism for valve control |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105764543A true CN105764543A (en) | 2016-07-13 |
| CN105764543B CN105764543B (en) | 2019-05-14 |
Family
ID=49725017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480066363.3A Active CN105764543B (en) | 2013-12-04 | 2014-11-27 | Portable infusion system including the stepping switch mechanism controlled for valve |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10183113B2 (en) |
| EP (1) | EP2881128B1 (en) |
| JP (1) | JP6517205B2 (en) |
| KR (1) | KR101852695B1 (en) |
| CN (1) | CN105764543B (en) |
| DK (1) | DK2881128T3 (en) |
| ES (1) | ES2698603T3 (en) |
| MX (1) | MX2016005382A (en) |
| PL (1) | PL2881128T3 (en) |
| RU (1) | RU2673861C2 (en) |
| SI (1) | SI2881128T1 (en) |
| WO (1) | WO2015082305A1 (en) |
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| CN113167258A (en) * | 2018-11-28 | 2021-07-23 | 英赛罗公司 | Drug delivery reciprocating pump system and valve assembly |
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| CN115190807A (en) * | 2020-01-31 | 2022-10-14 | 贝克顿·迪金森公司 | Valve shaft pump with coordinated pumping and valving operations |
| US11633541B2 (en) | 2017-01-19 | 2023-04-25 | Insulet Corporation | Cartridge hold-up volume reduction |
| US11672917B2 (en) | 2018-05-31 | 2023-06-13 | Insulet Corporation | Drug cartridge with drive system |
| US11746765B2 (en) | 2017-08-03 | 2023-09-05 | Insulet Corporation | Micro piston pump |
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| DK2881128T3 (en) | 2013-12-04 | 2019-01-28 | Hoffmann La Roche | Ambulatory infusion system comprising a step switch mechanism for valve control |
| DK2921189T3 (en) | 2014-03-17 | 2017-11-13 | Hoffmann La Roche | Initialization of a drug infusion dosing unit |
| AU2017277381B2 (en) * | 2016-06-07 | 2019-12-05 | F. Hoffmann-La Roche Ag | Valve drive unit with shape memory alloy actuator |
| RU2720297C1 (en) | 2016-07-08 | 2020-04-28 | Ф. Хоффманн-Ля Рош Аг | Flow detector |
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| DK3335746T3 (en) * | 2016-12-14 | 2020-07-20 | Hoffmann La Roche | Outpatient infusion unit |
| EP3335745B1 (en) | 2016-12-14 | 2019-12-11 | Roche Diabetes Care GmbH | Ambulatory infusion system initialization |
| US11786668B2 (en) | 2017-09-25 | 2023-10-17 | Insulet Corporation | Drug delivery devices, systems, and methods with force transfer elements |
| AU2019223659A1 (en) * | 2018-02-23 | 2020-07-09 | F. Hoffmann-La Roche Ag | Dosing unit refilling scheduling |
| US11698059B2 (en) | 2018-12-29 | 2023-07-11 | Biosense Webster (Israel) Ltd. | Disposable dual-action reciprocating pump assembly |
| US11730882B2 (en) * | 2018-12-29 | 2023-08-22 | Biosense Webster (Israel) Ltd. | Dual-action irrigation pump with variable speed to provide constant fluid flow |
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Also Published As
| Publication number | Publication date |
|---|---|
| SI2881128T1 (en) | 2019-01-31 |
| JP6517205B2 (en) | 2019-05-22 |
| EP2881128B1 (en) | 2018-10-24 |
| US20160317741A1 (en) | 2016-11-03 |
| DK2881128T3 (en) | 2019-01-28 |
| KR101852695B1 (en) | 2018-04-26 |
| WO2015082305A1 (en) | 2015-06-11 |
| US10183113B2 (en) | 2019-01-22 |
| KR20160065186A (en) | 2016-06-08 |
| EP2881128A1 (en) | 2015-06-10 |
| JP2016538958A (en) | 2016-12-15 |
| MX2016005382A (en) | 2016-08-08 |
| CN105764543B (en) | 2019-05-14 |
| ES2698603T3 (en) | 2019-02-05 |
| RU2673861C2 (en) | 2018-11-30 |
| PL2881128T3 (en) | 2019-04-30 |
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