CN105751501A - Manufacturing device and manufacturing method of large-size bone scaffold - Google Patents

Manufacturing device and manufacturing method of large-size bone scaffold Download PDF

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CN105751501A
CN105751501A CN 201610102050 CN201610102050A CN105751501A CN 105751501 A CN105751501 A CN 105751501A CN 201610102050 CN201610102050 CN 201610102050 CN 201610102050 A CN201610102050 A CN 201610102050A CN 105751501 A CN105751501 A CN 105751501A
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manufacturing
control
device
working
scaffold
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CN 201610102050
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CN105751501B (en )
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贺永
邵惠锋
傅建中
苟中入
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浙江大学
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56Porous materials, e.g. foams or sponges
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00Processes of additive manufacturing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y30/00Apparatus for additive manufacturing; Details thereof or accessories therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y50/00Data acquisition or data processing for additive manufacturing
    • B33Y50/02Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

The invention discloses a manufacturing device and a manufacturing method of a large-size bone scaffold. The manufacturing device comprises a three-dimensional motion working framework, an extrusion mechanism, a temperature control unit, a control panel and a working table, wherein the temperature control unit comprises a heating unit and a movable platform capable of driving the heating device to perform three-dimensional motion; the heating unit is controlled by the control panel; the temperature control unit is fixedly arranged on the working table; the extrusion mechanism and the working table are arranged on the working framework. The manufacturing device of the bone scaffold is simple in structure, convenient to operate and low in manufacturing cost; by use of the characteristics of bio-ink and accurate control of the control panel over the heating temperature according to the size of the scaffold, so that manufacturing of porous bone scaffold structures which have large size in a height direction and are different in shape is realized, and a beneficial material and technical support are provided for large bone defect treatment.

Description

一种大尺寸骨支架制造装置及其制造方法 One kind of a large-sized bone stent manufacturing apparatus and manufacturing method thereof

技术领域 FIELD

[0001]本发明涉及生物医学工程和组织工程技术领域,尤其是涉及一种大尺寸骨支架制造装置及其制造方法。 [0001] The present invention relates to a technical field of biomedical engineering and tissue engineering, particularly to a large size bone stent manufacturing apparatus and manufacturing method.

背景技术 Background technique

[0002]目前,随着社会的发展,各种创伤、骨肿瘤、人口老龄化等导致的骨缺损特别是长段骨缺损成为了骨科临床上的棘手问题。 [0002] Now, with the development of society, all kinds of trauma, bone tumors, aging population in particular bone defects caused by long bone defects become a thorny problem in orthopedics. 面对已有的传统骨缺损治疗方法包括自身骨移植、异体松质骨,以及其他骨移植方法等,存在供体不足、排异反应、手术耗费周期长等缺陷,骨组织工程技术在骨组织缺损治疗领域展现了它的优点,各种具有生物相容性、生物可降解性、具有高度连通有序通孔结构、可控孔形状和孔外形的多孔性骨支架被制造出来,使得细胞和养分能在支架中成功的运输,为细胞依附、生长和增值提供了空间。 The face of the existing traditional method of treating bone defects comprising bone graft itself, allograft cancellous bone, bone grafting, and other methods, the presence of donor shortage, rejection, operation takes long cycle defects in bone tissue engineering bone tissue defect therapeutic areas demonstrated its benefits, a variety of biocompatible, biodegradable, highly ordered communicating via structure, the shape and controlled pore porous bone shape bracket holes are produced, and such that the cell nutrients can be successful in the bracket transportation, it provides space for cell attachment, growth and value.

[0003]目前,已有的制造多孔骨支架的方法主要有,选择性激光烧结(selective lasersintering),三维印刷(three-dimens1nal printing),恪融沉积建模(fused deposit1nmodeling)和自动注楽成型(robocasting)等方法,这些方法都能制造出不同尺寸的骨支架结构,但针对于骨缺损中的长段骨缺损问题,上述方法都存在不同的缺陷。 [0003] Currently, existing methods for producing a porous scaffold mainly of bone, selective laser sintering (selective lasersintering), three-dimensional printing (three-dimens1nal printing), fusion deposition modeling Ke (fused deposit1nmodeling) and automatic injection molding yue ( robocasting) and other methods, these methods can produce different sized bone scaffold, but for a long period of problems in bone defects in bone defects, the above-described methods have various defects.

[0004] 如选择性激光烧结方法(例如申请号为201310282922.1的专利文献公开了一种可控多孔的陶瓷/聚合物基复合骨支架的制备方法,利用选择性激光烧结工艺,制备成类似天然骨组织的多孔陶瓷/聚合物基复合骨支架)的设备投入成本高,对制造骨支架的粉体要求高,由于超细的粉体使得设备对外部环境要求高,制造一个大尺寸的骨支架需要预先准备大量的粉体,激光束的光斑直径导致不能制造很细线条的骨支架结构。 [0004] The selective laser sintering process (e.g. Patent Application No. 201310282922.1 discloses a method for preparing a controlled porous ceramic / polymer composites bone scaffold, using a selective laser sintering process, similar to natural bone prepared high tissue porous ceramic / polymer composites bone scaffold) of the equipment investment costs, high requirements for manufacturing a bone scaffold powder, ultrafine powder such devices due to the high external environmental requirements, for manufacturing a large-sized bone scaffold requires a large amount of powder prepared in advance, the spot diameter of the laser beam can not cause a bone scaffold for producing very fine line.

[0005]三维印刷方法是利用设备中的挤出头挤出有粘结性的液滴,液滴落到正下方的粉体上,利用粘性液滴粘连粉体,形成一个具有三维孔结构的骨支架结构,液滴的粘性直接影响支架中线条的粗细,即制造的精度,对于骨支架结构如果内部孔小,结构内的没有粘结的粉体很难去除;熔融沉积建模方法存在只能用特定的热塑性聚合物材料,并且需要预先加工成丝才能制造;自动注浆成型方法能够制造多孔的骨支架结构,但不能制造像大段骨一样的长高度的结构,因为在制造过程中,材料无法继续支撑自身的重量,会坍塌。 [0005] The three-dimensional printing method using the extrusion head of the extrusion apparatus cementitious droplets, the droplets fall directly beneath the powder, powder adhesion using an adhesive droplets, to form a three-dimensional pore structure having bone support structure, droplet viscosity directly affects the thickness of the lines in the stent, i.e. the accuracy of manufacturing, if the internal structure of the bone scaffold small hole, no adhesion of the powder is difficult to remove within the structure; the presence of a fused deposition modeling method only use specific thermoplastic polymer material, and the need to pre-processed to wire in order to manufacture; slip casting method capable of automatically producing the porous structure of the bone scaffold, but not for producing massive bone as long as the height of the structure, because during the manufacturing process the material can no longer support its own weight, would collapse.

发明内容 SUMMARY

[0006]基于已有的制造大尺寸骨支架设备和方法遇到的问题,本发明提供了一种多孔的大尺寸骨支架制造装置,通过该装置,能够制造出大尺寸的多孔的在高度方向即Z方向大尺寸的骨支架结构。 [0006] Based on the problem of large-size bone scaffold conventional apparatus and method for producing encountered, the present invention provides a porous bone scaffold large-size manufacturing apparatus, by means of which the height direction can be manufactured in a large size porous i.e., a large-sized bone support structure in the Z direction.

[0007]本发明同时提供了一种新的骨支架制造方法,通过本发明方法,能够实现在高度方向大尺寸的多孔骨支架结构的制造,解决了制造多孔大段骨支架的问题,为后期大段骨缺损的治疗提供了很好的技术支持和材料。 [0007] The present invention also provides a novel method for producing a bone scaffold, by the method of the present invention can be realized in the production of porous bone scaffold large size in the height direction, to solve the problem of large bone producing a porous scaffold, for the latter large bone defects treatment provides a good technical support and materials.

[0008] —种大尺寸骨支架制造装置,包括工作台面、挤出机构、驱动工作台面或挤出机构三维运动的工作框架以及温控单元,所述温控单元包括加热单元,以及驱动加热单元三维运动的运动平台;所述加热单元包括与所述运动平台固定的固定架以及设置在固定架上的加热块,该加热块围成对骨支架进行加热的工作空间。 [0008] - large size species bone scaffold manufacturing apparatus, comprising a countertop, the extrusion mechanism, the drive mechanism extruded countertop or three-dimensional motion of the framework and a temperature control means, said temperature control unit comprises a heating unit, a heating unit and a driving three-dimensional movement of the motion platform; said heating means comprises a moving platform of the stationary holder and a heating block on the holder, the pair of the heating block surrounding bone scaffold work space heating.

[0009]本发明的工作框架一般包括X轴轨道,Y轴轨道,Z轴轨道,通过滑块相互配合,实现三维运动。 [0009] The framework of the present invention generally includes an X-axis rails, Y-axis rail, Z-axis rail, the slider cooperate with each other, three-dimensional motion. 作为优选,所述的挤出机构固定安装在工作框架的X轴轨道上,其可以是气动挤出装置,也可以是机械式活塞挤出装置,还可以是机械式螺杆挤出装置。 Advantageously, said extrusion means fixedly mounted on the X-axis rails of the framework, which may be pneumatic extrusion means may be a piston extrusion mechanical means may also be a mechanical screw extrusion apparatus.

[0010]作为优选,还包括控制板,所述加热单元受控于该控制板;所述加热单元还包括检测骨支架周围环境温度的温度传感器,控制板采集该温度传感器的温度信号,根据温度信号大小实现对加热单元的控制。 [0010] Advantageously, further comprising a control panel, the heating unit is controlled by the control panel; said heating unit further comprises a bone scaffolding ambient temperature detected by the temperature sensor, the temperature signal acquisition board temperature sensor based on the temperature signal magnitude to achieve control of the heating unit.

[0011]骨支架的形状一般为圆柱体型,为了使支架能够受热均匀,固定架的形状设计成U型或者半圆弧型,在制造支架时,支架的中心位于加热块的中心位置附近,使得支架能够均匀的受热。 [0011] The shape of the bone is generally cylinder-type stent, the stent can be heated evenly in order to make the shape of the holder is designed as a U-shaped or semi-circular arc, during the production of the stent, the stent is located in the center position near the center of the heating block, such that the stent can be uniformly heated. 所以,作为优选,所述固定架一端与运动平台安装固定,另一端设有U型或者半圆弧型的安装端,所述加热块固定在安装端内,呈U型或者半圆弧型布置。 Therefore, preferably, the holder with the motion platform fixed end, the other end is provided with a mounting end of a U-shaped or semi-circular arc, the heating block is fixed in the mounting end is U-shaped or semicircular arc arrangement .

[0012]作为优选,所述加热块为加热膜,加热线圈,加热板等中的一种。 [0012] Advantageously, the heating block is heated as a film, a heating coil, a heating plate or the like.

[0013]为了防止加热块产生的加热环境过大,使得在制造过程中的线条的水分过快蒸发,影响前一层与后一层的线条之间的粘结性能,使得骨支架不能成为一体,上下支架分离,上述的加热块不能太大,同时,对于横截面积很大的支架,如果加热块太小,会导致加热不充分,骨支架结构坍塌,厚度在3_到15mm之间,可以根据不同的支架,选择不同厚度的加热块和提供不同的加热温度。 [0013] In order to prevent heat generated by ambient excessive heating block, such that the water line in the manufacturing process is too fast evaporated before impact bonding properties between the layer and the latter layer lines, such that the bone holder can be integrally , separation of the vertical frame, the above-described heating block is not too large, while a large cross sectional area for the stent, if the heating block is too small, resulting in insufficient heating, bone scaffold structure collapses, 3_ to a thickness of between 15mm, the stent may be different, the heating block select different thicknesses and provide different heating temperatures. 作为优选,所述加热块的厚度在3_到15_之间。 Advantageously, the thickness of the heat block between 3_ to 15_.

[0014]本发明中所述的固定架可以更换,通过更换不同尺寸,不同形状的支架,可以实现不同尺寸,不同形状的骨支架的制造。 [0014] The holder of the present invention can be replaced by the replacement of different sizes, different shapes of the stent can be achieved in different sizes, different shapes for producing a bone of the stent.

[0015]作为优选,所述运动平台包括: [0015] Advantageously, the motion platform comprising:

[0016]与工作台面固定第一水平轨道; [0016] level and a first rail fixed working table;

[0017]垂直滑动设置在第一水平轨道上的第二水平轨道; [0017] The second horizontal rails disposed vertically slidable in a first horizontal rail;

[0018]竖直滑动设置在第二水平轨道上的Z轴轨道; [0018] Z-axis rail slides vertically disposed on the second horizontal rail;

[0019]所述固定架通过滑块与Z轴轨道滑动设置。 [0019] The slider holder slidably disposed through the Z-axis rail.

[0020]上述第一水平轨道、第二水平轨道可选择X轴轨道或者Y轴轨道中任一种。 [0020] The first horizontal rail, the second rail selectable horizontal X-axis and Y-axis rail track either. 所述固定架固定安装在上述运动平台的Z轴轨道上,所述Z轴轨道固定安装在X、Y轴轨道上,所述X、Y轴轨道固定安装在上述工作台面上。 The fixation rail is mounted on the Z-axis of the moving platform, said Z-axis rail fixedly mounted on the X, Y-axis rail, the X, Y-axis rail mounted on the work table is fixed. 本发明的加热块和温度传感器都与控制板相连,在制造支架的过程中,控制板控制加热块对骨支架周围的环境进行加热,温度传感器对环境温度进行检测,把检测到的温度实时传输给控制板,形成一个闭环温度控制回路,通过控制板内的算法,再次控制加热块,使得支架周围的温度控制在一定设计的温度范围内。 Heating block temperature sensor and the control board of the present invention are connected, in the process of manufacturing the stent, the control panel of the heating block surrounding bone scaffold environment is heated to a temperature sensor for detecting ambient temperature, the temperature detected by the real-time transmission to the control panel, forming a closed loop temperature control, by an algorithm in the control panel, controlling the heating block again, such that the ambient temperature is controlled within a certain stent design temperature range. 在制造过程中,热量传递到加热块对应位置的支架内部,加速骨支架内部水分的蒸发,使得支架能够在短时间内固化,在支撑自身重量的同时,也能够支撑后面即将在其上方打印的骨支架结构。 In the manufacturing process, heat is transferred to the heating block corresponding to the inner support position, accelerate the evaporation of moisture inside the bone scaffold, such that the stent can be cured in a short time, to support its own weight at the same time, it is possible later to be printed on the support over which the bone scaffold structure.

[0021]根据需要制造的支架在工作面上的位置,加热装置在运动平台的作用下,可以快速方便的到达指定的位置,给支架进行加热,同时根据支架的大小,在控制板的作用下,利用预先设定的温度控制参数对支架进行加热。 [0021] The need to make the stent in position of the working surface, the heating means under the effect of movement of the platform, can be quickly and easily reaches the specified position, the stent is heated to, at the same time according to the size of the stent, the role of the control panel at by the temperature control parameter set in advance by heating the stent.

[0022] 一种大尺寸骨支架制造方法,采用上述任一方案所述的大尺寸骨支架制造装置,包括以下步骤: [0022] A method for producing a large-sized bone scaffold, a bone using a large-sized stent manufacturing apparatus according to any preceding embodiment, comprising the steps of:

[0023]首先,把粉体和粘性液体按一定的比例混合,配置挤出装置所需要的高粘度的生物墨水; [0023] First, the viscous liquid and powder certain proportions, the configuration of the ink means any biological extruding high viscosity;

[0024]然后: [0024] then:

[0025] (I)利用分层软件将需要制造的骨支架三维结构模型分层切片处理,形成相应代码,即:将需要制造的骨支架三维结构模型输入计算机,利用分层软件分层切片处理,形成相应代码输入到骨支架制造装置中; [0025] (I) will need to be manufactured using a layered software structure of three-dimensional model of the bone scaffold slicing process, to form the corresponding codes, namely: the need to create a three-dimensional structure of the bone scaffold into the computer model, the use of layered software slicing process to form the corresponding code into the bone scaffold manufacturing apparatus;

[0026] (2)根据代码,挤出机构将预先配置好的生物墨水喷射到位于正下方的工作台面上,加热单元同时在运动平台驱动下实时调整加热位置,工作面上获得Z方向长尺寸的三维骨支架结构;即:加热装置根据制造的三维骨支架结构的具体尺寸在三维运动平台下全方位调整,同时随时改变温度值,并且温控装置和工作面一起沿Z轴向下运动,在工作面上获得可控的Z方向长尺寸的三维骨支架结构; [0026] (2) based on the code, extrusion biological mechanism preconfigured ink onto the work surface is located directly below the heating unit is heated while adjusting the position of the moving platform driven in real time, to obtain a long working surface direction Z the three-dimensional structure of the bone scaffold; i.e.: heating means adapted to the specific size of the full three-dimensional structure of the bone scaffold fabricated in three-dimensional motion platform, while varying the temperature value at any time, and the Z-axis direction together with the movement of the temperature control device and the face, obtaining a controlled work surface direction of the long dimension Z three dimensional structure of the bone scaffold;

[0027] (3)把得到的骨支架结构在80〜120 °C烘箱中干燥20〜48小时,然后放到高温炉内高温1000〜1500°C保温2〜4小时,最后冷却得到骨支架结构。 [0027] (3) the structure of the bone scaffold obtained at 80~120 ° C oven for 20~48 hours, and then placed in a high temperature furnace insulation temperature 1000~1500 ° C ~ 4 hours, and finally cooled to give a bone scaffold .

[0028]作为优选,所述三维骨支架结构为柱形结构;所述固定架一端与运动平台安装固定,另一端设有U型或者半圆弧型的安装端,所述加热块固定在安装端内,呈U型或者半圆弧型布置;所述三维骨支架结构设置在加热块中心位置。 [0028] Advantageously, the three-dimensional structure of the bone is cylindrical stent structure; the fixture fixed at one end to the motion platform, and the other end is provided with a mounting end of a U-shaped or semi-circular arc, the heating block to the mounting an inner end, a U-shaped or semicircular arc disposed; the three-dimensional structure of the bone scaffold center position is provided in a heating block.

[0029]作为优选,所述的挤出装置中的生物墨水是一种高粘度的溶液,可以是水凝胶溶液和粉体的混合物,其具有自我支撑的能力,同时随着水分的蒸发,溶液会变硬。 [0029] Preferably, the bio-ink said extrusion apparatus is a high viscosity solution, hydrogel solution may be a mixture of powder and which has the ability to be self-supporting, and with the evaporation of water, the solution will harden.

[0030]作为优选,所述生物墨水为水凝胶溶液和粉体的混合物; [0030] Advantageously, the ink is a mixture of biological hydrogel solution and powder;

[0031 ] 所述水凝胶溶液为PVA水凝胶溶液、CMC水凝胶溶液、PEG水凝胶溶液中的一种或几种混合; [0031] The aqueous solution of a PVA hydrogel hydrogel solution, the CMC hydrogel solution, or a mixture of several PEG hydrogel in a solution;

[0032]所述粉体可以是硅酸盐、磷酸盐、生物玻璃中的一种或几种的混合,其粒径在I到1微米之间。 [0032] The powder may be a silicate, phosphate, bioglass several mixing of one or a particle size between 1 micron in I.

[0033]作为进一步优选,所述PVA水凝胶溶液中PVA的质量百分比浓度在1%〜15% ,CMC水凝胶溶液中的CMC的质量百分比浓度在0.5%〜4%,PVA水凝胶溶液为小分子量的溶液,例如平均分子量为2000以下。 [0033] As a further preferred mass concentration aqueous gel solution of PVA in the PVA 1% ~15%, CMC aqueous gel solution of CMC at a mass concentration of 0.5% ~4%, PVA hydrogels solution is a solution of low molecular weight, such as an average molecular weight of 2000 or less.

[0034]作为优选,所述大尺寸骨支架制造装置包括还包括控制板,所述加热单元受控于该控制板;所述加热单元还包括检测骨支架周围环境温度的温度传感器,控制板采集该温度传感器的温度信号,根据温度信号大小实现对加热单元的控制; [0034] Advantageously, the large-sized manufacturing apparatus comprises a bone scaffolding further comprises a control panel, the heating unit is controlled by the control panel; said heating unit further comprises a bone scaffolding ambient temperature detected by the temperature sensor, the acquisition control board temperature signal of the temperature sensor, the temperature control signal magnitude is achieved according to the heating unit;

[0035]如果检测到的温度低于控制板设定的温度,则控制板输出控制信号给加热块,加热块继续加热; [0035] If the detected temperature is lower than the set temperature of the control board, the control board outputs a control signal to the heating block, heating was continued heating block;

[0036]如果检测到的检测到温度达到或低于设定温度时,控制板继续进行判断: [0036] If the detected temperature detected reaches or falls below the set temperature, the control board is determined to continue:

[0037]如果在设定时间内,设定温度与检测到的温度差值小于等于设定值,则控制加热块停止工作; [0037] If within the set time, set temperature and the detected temperature difference is less than equal to the set value, the control stops heating block;

[0038]如果在设定时间内,设定温度与检测到的温度差值大于设定值,降低加热块的功率,控制板继续控制加热块工作。 [0038] If the temperature difference within the set time, set temperature and the detected than the set value, reducing power to the heating block, the heating block control panel continues to work.

[0039]与现有技术相比,本发明具有如下优点: [0039] Compared with the prior art, the present invention has the following advantages:

[0040] —、本发明的骨支架制造装置结构简单,操作方便,制造成本低,利用生物墨水的特性,再加上控制板对加热温度的精确控制,实现高度方向大尺寸的多孔骨支架结构的制造。 [0040] - simple bone scaffold structure manufacturing apparatus according to the present invention, convenient operation, low manufacturing costs, the use of biological characteristics of the ink, plus precise control of the heating temperature of the panel, the height direction to achieve a large-sized porous bone scaffold manufacturing.

[0041] 二、本发明的制造装置可以制造不同尺寸的骨支架结构,只需要事先更换相应的加热块和支架,操作简单方便。 [0041] Second, the manufacturing apparatus of the present invention may be manufactured in different sizes of bone scaffold structure, only to replace the corresponding previously heating block and bracket, easy to operate.

[0042]三、本发明的制造装置可以制造不同形状的骨支架结构,包括管状结构,实心圆柱体结构,以及薄片结构,只需要更改输入的支架三维模型结构。 [0042] Third, the manufacturing apparatus can manufacture a bone supporting structure of the present invention of different shapes, including tubular structures, a solid cylindrical structure, and a sheet structure, only need to change the three-dimensional input model structure of the stent.

[0043]四、本发明的制造装置制造的多孔骨支架解决了大段骨制造的问题,为组织工程中的大段骨缺损治疗提供了有利的材料支持。 [0043] Fourth, the porous bone scaffold manufacturing apparatus for producing the present invention solves the problem of manufacturing large section of bone, the material provides a favorable support for Treatment of segmental bone defects in tissue engineering.

附图说明 BRIEF DESCRIPTION

[0044]图1是本发明的大尺寸骨支架制造装置的结构示意图; [0044] FIG. 1 is a schematic view of the present invention is a large-sized apparatus for manufacturing bone scaffold;

[0045]图2是本发明的大尺寸骨支架的制造方法流程示意图; [0045] FIG 2 is a flowchart of a method for manufacturing a large-sized bone scaffold is a schematic view of the present invention;

[0046]图3是本发明的温控单元的结构示意图; [0046] FIG. 3 is a schematic diagram of the temperature control unit according to the present invention;

[0047]图4是本发明的温控单元工作原理流程图; [0047] FIG. 4 is a flowchart of the temperature control unit according to the present invention works;

[0048]图5是本发明的温控单元加热温度控制图; [0048] FIG 5 is a temperature control means controlling the heating temperature FIG invention;

[0049]图6是本发明的骨支架制造过程中加热单元的位置变化示意图; [0049] FIG. 6 is a schematic view of the position of a bone scaffold according to the present invention, the manufacturing process of the heating unit changes;

[0050]图7是本发明制造的多孔性骨支架实物图; [0050] FIG. 7 is a pictorial diagram of a porous bone scaffold manufactured according to the present invention;

[0051]图中:I为三维运动工作框架,2为挤出机构,3为温控单元,4为工作台面,5为X、Y轴运动平台,6为Z轴运动平台,7为支架,8为加热块,9为温度传感器。 [0051] FIG: I is a three-dimensional movement of the working frame, 2 for the extrusion means, for the temperature control unit 3, 4 to the work surface 5 of X, Y axis motion platform, the Z-axis motion platform 6, 7 is a stent, 8 is a heating block, 9 a temperature sensor.

具体实施方式 detailed description

[0052]如图1、图3和图6所示,一种大尺寸骨支架制造装置,包括:三维运动工作框架1、挤出机构2,温控单元3,控制板以及工作台面4; [0052] As shown in FIG. 1, FIG. 3 and FIG. 6 A large-sized bone scaffold manufacturing apparatus, comprising: a three-dimensional moving framework, the extrusion mechanism 2, the temperature control unit 3, the control board and the work table 4;

[0053] 如图1所示,三维运动工作框架I包括通过相对固定的四个立柱,以及固定在立柱顶部的Y轴工作轨道、X轴工作轨道,X轴工作轨道底部设有与Y轴工作轨道滑动配合的Y轴滑块;挤出机构2顶部一侧设有与X轴工作轨道滑动配合的X轴滑块。 [0053] As shown, three-dimensional motion includes a framework 1 I shown by four relatively stationary column, and the Y axis rails fixed to the top of the working column, the work of the X-axis rail, a bottom rail with the X-axis work and the work of the Y-axis Y-axis slider rails slidably fitted; a top side 2 is provided with an extrusion mechanism and the X-axis X-axis slider track work sliding fit. 通过Y轴滑块、X轴滑块的移动,可实现挤出机构2Χ轴、Y轴方向的移动。 The Y-axis slider, moving the X-axis slider can be achieved extrusion mechanism 2Χ axis, the Y-axis direction. 三维运动工作框架I上同时设有Z轴轨道,工作台面4通过Z轴滑块与Z轴轨道滑动配合。 Also features a three-dimensional movement of the Z-axis rails framework I, work table 4 by the Z-axis slider sliding fit with the Z-axis rail. X轴滑块、Y轴滑块、Z轴滑块均可以通过丝杠和电机驱动。 X-axis slider, Y-axis slider, Z-axis slider can be driven by a motor and lead screw.

[0054]挤出机构2固定安装在三维运动工作框架I的X轴上,其可以是气动挤出机构,也可以是机械式活塞挤出机构,还可以是机械式螺杆挤出机构。 X-axis [0054] The extruder 2 is fixedly mounted in the three-dimensional movement of the framework I, which may be pneumatic extrusion means may be a piston extrusion mechanical means, may also be a mechanical screw extruder mechanism.

[0055]挤出机构2中的生物墨水是一种高粘度的溶液,可以是水凝胶溶液和粉体的混合物,其具有自我支撑的能力,同时随着水分的蒸发,溶液会变硬。 [0055] Biological ink extrusion mechanism 2 is a high viscosity solution, hydrogel solution may be a mixture of powder and which has the ability to be self-supporting, and with the evaporation of water, the solution will harden. 上述水凝胶溶液可以是PVA,CMC,PEG等溶液中的一种或几种混合,PVA的质量百分比浓度在I %〜15 %,CMC的质量百分比浓度在0.5 %〜4 %,PEG用低分子量的溶液,比如PEG-200,PEG-400,PEG-600,PEG-800,PEG-1000 等。 The aqueous gel solution may be mixed with one or more of PVA, CMC, PEG and the like in the solution, the mass concentration of PVA in I% ~15%, CMC mass percentage concentration of 0.5% ~4%, PEG with a low the molecular weight of the solution, such as PEG-200, PEG-400, PEG-600, PEG-800, PEG-1000 and the like.

[0056]上述粉体可以是硅酸盐,磷酸盐,生物玻璃中的一种或几种的混合,其粒径在I到1微米之间。 [0056] The powder may be a silicate, phosphate, bioglass several mixing of one or a particle size between 1 micron in I.

[0057] 温控单元3包括加热单元以及驱动加热单元三维运动的运动平台,加热单元受控制板控制;温控单元3固定安装在工作台面4上。 [0057] The temperature control unit 3 comprises a heating unit and a motion platform driving the heating unit of the three-dimensional motion, the heating unit by a control panel; temperature control unit 3 is fixedly mounted on the work table 4.

[0058]如图3所示,上述加热单元包括固定架7、固定在固定架7上的加热块8、固定安装在固定架7两个端部的温度传感器9。 [0058] As shown in FIG. 3, the heating means comprises a holder 7, fixed on the heat block 8 in the holder 7, the temperature sensor 7 is fixedly mounted at both end portions of the holder 9. 固定架7固定安装在上述运动平台的Z轴运动平台6上,Z轴运动平台6固定安装在X、Y轴运动平台5上,X、Y轴运动平台5固定安装在上述工作台面4上。 Bracket 7 fixedly mounted on the Z-axis motion of the moving platform, the platform 6, Z-axis motion platform 6 is fixedly mounted in the X, the Y-axis moving table 5, X, Y axis motion platform 5 is fixedly mounted on the work table 4. 上述的加热块8和温度传感器9都与控制板相连,通过Χ、Υ轴运动平台5和Z轴运动平台6的运动,控制固定架7在三维空间内的运动,从而控制固定架7上的加热块8的运动,使其对固定架7进行均匀的加热。 Block 8 and the above heating temperature sensor 9 are connected to the control plate, through the movement Χ, Υ-axis motion platform 5 and the Z-axis motion platform 6, 7 controlling movement of the holder in the three-dimensional space, thereby controlling the fixed frame 7 heating the motion block 8, the holder 7 so as to be uniformly heated. 上述的Χ、Υ轴运动平台5—般包括与工作台面4相对固定的X轴轨道和Y轴轨道,X轴轨道和Y轴轨道之间通过X轴滑块相连,X轴滑块可通过电机驱动;比如,当设置X轴滑块时,Y轴轨道通过X轴滑块与X轴轨道滑动配合。 Above Χ, Υ-axis motion platform 5- typically includes work surface 4 relative to the fixed X-axis and Y-axis rail track connected to the X-axis slide rails between the X-axis and Y-axis rails, the X-axis slider by a motor drive; For example, when the X-axis slider disposed, Y-axis by the X-axis slide rails and the X-axis rail sliding fit. Z轴运动平台6—般也由Z轴轨道和Z轴滑块构成,Z轴轨道底部可通过Y轴滑块与Y轴轨道滑动配合;固定架7远离加热块8的一端通过Z轴滑块与Z轴轨道滑动配合。 Z-axis motion platform generally be made of 6- Z-axis rail and the Z-axis slider, the bottom of the Z-axis rail slidably fitted with the Y-axis Y-axis slide rails; holder 7 is heated by the Z-axis away from the one end of the slide block 8 and Z-axis rail sliding fit. 在制造过程中,热量通过热传导和对流慢慢传递到加热块对应位置的骨支架内部,加速骨支架内部水分的蒸发,使得骨支架能够在短时间内固化,在支撑自身重量的同时,也能够支撑后面即将在其上方打印的骨支架结构。 In the manufacturing process, heat slowly by conduction and convection heat transfer to the interior of the bone holder position corresponding to the heating block, accelerate the evaporation of moisture inside the bone scaffold, so that the bone holder can be cured in a short time, at the same time to support its own weight, it is possible to the back bone scaffold support structure about to be printed above it.

[0059]根据需要制造的骨支架在工作台面上的位置,加热单元在运动平台的作用下,可以快速方便的到达指定的位置,给骨支架进行加热,同时根据骨支架的大小,在控制板的作用下,利用预先设定的温度控制参数对骨支架进行加热。 [0059] The bone at the position of the stent need to make a countertop, under the effect of the heating unit movement of the platform, can be quickly and easily reaches the specified position, the stent is heated to a bone, while the holder according to the size of the bone, in the board under the action, with a temperature control parameter set in advance to be heated bone scaffold.

[0060]上述的加热块8可以是加热膜,加热线圈,加热板等中的一种。 [0060] The heat block 8 may be a film is heated, the heating coil, a heating plate or the like.

[0061]为了防止加热块8产生的加热环境过大,使得在制造过程中的线条的水分过快蒸发,影响前一层与后一层的线条之间的粘结性能,使得骨支架不能成为一体,上下骨支架分离,上述的加热块不能太大,同时,对于横截面积很大的支骨架,如果加热块太小,会导致加热不充分,骨支架结构坍塌,厚度在3_到15_之间,可以根据不同的骨支架,选择不同厚度的加热块和提供不同的加热温度。 [0061] In order to prevent heat generated by the heating block 8 environment is too large, so that the water line in the manufacturing process is too fast evaporated before impact bonding properties between the layer and the latter layer lines, such that the bone holder can not be integrally, separate upper and lower bone scaffold, can not be too much above the heating block, while a large cross sectional area for the branched backbone, if the heating block is too small, resulting in insufficient heating, bone scaffold structure collapses, to a thickness of 15 3_ _ between, depending on the bone holder can select different thicknesses and the heating block to provide different heating temperatures. 在制造骨支架的过程中,加热块的位置要比挤出机构低,防止加热块在给骨支架提供热量的过程中,使得挤出机构内的未挤出的溶液过分蒸发,影响溶液的流动性,从而影响线条的挤出和整个结构的制造,一般选择在挤出机构已经制造完一部分骨支架后,开始对骨支架进行加热处理。 In the process for producing a bone holder, the position of the heating block lower than the extrusion means, during the heat block to prevent heat provided to the bone holder, such that the extruded solution is not within the extruder excessive evaporation mechanism, the influence of the flow of the solution resistance, thus affecting the entire structure and manufacturing extrusion line, usually after selection has been completed for producing extrusion mechanism holder portion of the bone, bone scaffold starts heat treatment.

[0062]固定架7可以更换,通过更换不同尺寸,不同形状的固定架,可以实现不同尺寸,不同形状的骨支架的制造。 [0062] The bracket 7 can be replaced by the replacement of different sizes, different shapes of the holder, can be realized in different sizes, different shapes for producing a bone of the stent.

[0063]骨支架的形状一般为圆柱体型,为了使骨支架能够受热均匀,固定架7的形状设计成U型或者半圆弧型,在制造骨支架时,骨支架的中心位于加热块8的中心位置附近,使得骨支架能够均匀的受热。 [0063] The shape of the bone is generally cylinder-type stent, the stent can be heated in order to make uniform the bone, the shape of the holder 7 is designed as a U-shaped or semi-circular arc, during the production of the bone holder, the center of the bone holder of the heating block 8 near the center position, so that the bone holder can be uniformly heated.

[0064]如图4所示,是本发明的温控单元工作原理流程图,在制造骨支架的过程中,首先把骨支架模型导入计算机,控制板根据骨支架的横截面尺寸和高度方向的尺寸,通过已有的温度控制方法得到相应的温度参数,控制加热块对骨支架周围的环境进行加热,温度传感器对环境温度进行检测,把检测到的温度实时传输给控制板,形成一个闭环温度控制回路,如果检测到的温度低于控制板设定的温度,则控制板输出数据给加热块,加热块继续工作,当检测到环境温度达到设定温度时,控制板继续按照设定的程序进行判断,如果在一段时间内,设定温度与检测到的温度差值比较小,自动认为当前热量流失比较少,则控制加热块停止工作,直到超出设定温度的下限时,控制加热块继续工作,如果在一段时间内,设定温度与检测到的温度差值比较大,则认为当 [0064] As shown in FIG 4, the temperature control unit is a flowchart of operation of the present invention, the process for producing a bone of the stent, the first stent bone model into a computer, according to cross-sectional dimensions of the control panel and the height direction of the bone scaffold size, obtained by a conventional method of controlling the temperature of the respective temperature parameters, control of the heating block surrounding bone scaffold environment is heated to a temperature sensor for detecting ambient temperature, the temperature detected real-time transmission to the control panel, forming a closed-loop temperature control circuit, if the detected temperature is lower than the set temperature of the control board, the control board to the heating output data block, the heating block continues to operate, when the detected temperature reaches the set temperature, the control panel in accordance with the procedures set continued the determination, if the temperature difference over a period of time, the set temperature is detected is relatively small, that the current automatic less heat loss, the heating control block stop working until beyond the lower limit of the set temperature, the heating control block continues work, if a period of time, set temperature and the detected temperature difference is relatively large, it is considered that when 前热量流失比较多,控制板继续控制加热块工作,只是放低加热功率,通过实时比较设定温度与检测温度的差值,调节加热块的加热功率,确保环境温度在一个设定的容许的范围内变化。 More heat loss before, the control panel continues to work heating block, the heating power is only lowered by the difference between the set temperature and real-time comparison of the detected temperature, adjusting the heating power of the heating block, to ensure that the allowable ambient temperature for a set of changes in scope.

[0065]如图5所示,是针对不同横截面积尺寸和高度尺寸的骨支架结构,所对应的温度调控范围图,当骨支架横截面积比较小时,不需要太高的温度,温度就能传到骨支架的内部,相反,当骨支架横截面积很大时,由于温度的传热速度相同,在相同的时间内,在同一温度下,在骨支架制造过程中,会导致骨支架的内部没有达到足够的温度,以致水分蒸发过慢,无法支撑其上方的骨支架结构,导致结构无法成型,甚至导致坍塌,所以需要更高的温度使得在相同的时间内,温度能够传热到骨支架内部,即使是高度很低的骨支架,由于此时骨支架的横截面积比正常时候要大很多,因此常温下的水分蒸发速度无法满足要求,所以还是需要加热单元的辅助,同时,对于不同高度的骨支架,当高度比较低时,骨支架上部分的结构重量比较轻,骨支架的下部分完全可 [0065] As shown in FIG. 5 is a structural scaffold for bone size and height of different cross-sectional dimensions, the temperature control range corresponding to FIG, relatively small cross-sectional area when the bone scaffold, does not require high temperature, the temperature is can propagate to the internal bone scaffold, on the contrary, when the bone holder large cross-sectional area, the heat transfer rate is the same as the temperature at the same time, at the same temperature, the bone scaffold manufacturing process, can cause bone scaffold the internal temperature does not reach a sufficient, so that the water evaporates too slowly, the stent structure can not support the bone above it, resulting in the structure can not be formed, and even lead to collapse, so that a higher temperature is required at the same time, capable of transferring heat to a temperature internal bone scaffold, even highly low bone scaffold, at this time since the cross-sectional area of ​​the bone scaffold much larger than the normal time, so the moisture evaporation rate at room temperature, can not meet the requirements, it is necessary to heat the secondary unit while, bone scaffold for different heights, when the height is low, the bone support structure relatively light weight of the portion, the lower portion of the bone holder can be completely 以支撑,就不需要进行加热处理,或者把温度控制在室温,对于高度高的骨支架,需要进行加热处理,利用线条的固化来骨支撑后面的结构,具体的温度控制参数可以从图5上看出来,当横截面积大,高度又高时,所需要的加热温度最高,对于小尺寸的支架,可以不加热。 In support, it does not require heat treatment, or to control at room temperature, for high altitude bone holder, the need for a heat treatment, curing by lines to the back bone support structure, particularly on temperature control parameters may FIG 5 from see, when a large cross-sectional area, and the height is high, the required maximum heating temperature, for a small-sized stent may not be heated.

[0066]本发明的装置制造的骨支架结构尺寸在横截面积的分界尺寸是225mm2和900mm2,高度的分界尺寸是15mm,25mm和50mm,对于不同材料的生物墨水,其水分蒸发速度也不同,因此温度存在一个波动,在分界尺寸附近也存在一定的交集。 [0066] The size of the device for producing a bone scaffold according to the present invention at the boundary of the cross-sectional area is 225mm2 and the size of 900mm2, the height of the boundary size 15mm, 25mm and 50mm, for inks of different biological materials, the moisture evaporation rate is different, Thus there is a temperature fluctuation, there are some boundary in the vicinity of the intersection of dimensions.

[0067]考虑到不同的季节,温度反差大,为了保证支架条件一致,把环境的温度控制在一个恒温范围内,20〜24°C。 [0067] Taking into account the different seasons, large temperature contrast, in order to ensure consistent conditions holder, the temperature of the environment within a controlled temperature range, 20~24 ° C.

[0068] 如图2所示,一种大尺寸骨支架制造方法,包括以下步骤: [0068] As shown A method for manufacturing a large-sized bone holder 2, comprising the steps of:

[0069] I)把粉体和粘性液体按一定的比例混合,配置挤出机构所需要的高粘度的生物墨水; [0069] I) the powder and viscous liquids certain proportions, extrusion configuration biological mechanism required high viscosity ink;

[0070] 2)将需要制造的骨支架三维结构模型输入计算机,利用分层软件分层切片处理,形成相应代码输入到骨支架制造装置中,层高设置在0.1〜0.4毫米,挤出线条大小为0.1〜 [0070] 2) the need for producing three-dimensional structure of the bone scaffold into the computer model, the use of layered software slicing process, to form the corresponding code into the bone scaffold manufacturing apparatus, in the story provided 0.1~0.4 mm, the size of the extrusion line as 0.1~

0.5mm,挤出线条间距为50〜2000微米,挤出机构运动速度为2〜40mm/s; 0.5mm, line spacing 50~2000 microns extruded, the extrusion speed of the movement mechanism 2~40mm / s;

[0071] 3)控制板控制所有装置工作,挤出机构在三维运动工作框架的作用下运动到设定的骨支架制造位置,由挤出机构将生物墨水喷射到位于正下方的工作台面上,加热单元根据制造的三维骨支架结构的具体尺寸在三维运动平台下全方位调整,同时随时改变温度参数和加热功率,当制造完一层支架结构时,温控单元和工作台面一起沿三维运动工作框架的Z轴轨道向下运动一层的距离,同时加热块在随后沿运动平台的Z轴轨道上移一段距离,给刚挤出来的骨支架结构进行加热,循环往复,最后在工作台面上获得可控的Z方向长尺寸的三维骨支架结构。 [0071] 3) All the control panel device is operated, extruding mechanism for producing the movement to the position of the bone holder set in motion under the action of the three-dimensional framework by the extrusion mechanism to the ink jet biological positioned directly below the work surface, the heating unit according to the specific dimensions of the three-dimensional structure of the bone scaffold fabricated round adjustment in three-dimensional moving platform, while changing the parameters and the temperature of the heating power at any time, when manufacturing the finished scaffold layer, the temperature control unit and the work surface with the working motion in three dimensions Z-axis downward movement distance rail frame layer, while in a subsequent heating block shifted a distance along the Z-axis motion platform rails, to just squeezed bone scaffold structure is heated, the cycle, finally obtaining a countertop controllable direction of the long dimension Z three dimensional structure of the bone scaffold.

[0072] 4)把得到的支架结构在100 0C烘箱中干燥24小时,然后放到高温炉内高温1200 V保温3小时,最后炉内室温冷却得到骨支架结构。 [0072] 4) The resulting stent structure is dried in an oven at 100 0C for 24 hours and then placed in a high temperature furnace temperature 1200 V for 3 hours, and finally furnace cooled to room temperature to obtain a bone scaffold.

[0073] 实施例 [0073] Example

[0074]如图7所示,是利用本发明的骨支架制造装置制造的高度方向大尺寸的多孔骨支架,以硅酸盐材料的骨支架结构为例,来说明支架的具体制造过程: [0074] As shown in FIG. 7, a bone scaffold is a porous bone scaffold manufacturing apparatus of the present invention for producing a large size in the height direction, to the structure of the bone scaffold silicate material for example, to illustrate specific stent manufacturing process:

[0075] I)通过化学合成方法制备硅酸盐粉体,通过球磨处理得到5到10微米大小的粉体,配置浓度在5 %到8 %之间的PVA水溶液,然后把粉体和溶液按重量比1.4〜1.6:1的比例混合均匀,得到可挤出的高粘度的生物墨水; [0075] I) prepared by a chemical synthesis method silicate powder, powder obtained by the ball mill treatment, configure a concentration of 5 to 10 microns in size between 5% aqueous solution of PVA to 8%, and then the powder was press 1.4~1.6 weight ratio: 1 ratio mixed uniformly to obtain a biological extrudable high viscosity ink;

[0076] 2)将需要制造的骨支架圆柱体结构模型输入计算机,利用分层软件分层切片处理,形成相应代码输入到骨支架制造装置中,层高设置在0.5毫米,挤出线条大小为1mm,挤出线条间距为1.9_,挤出机构运动速度为15mm/s ; [0076] 2) The bone scaffold cylindrical structure necessary to manufacture a model input to a computer, using the layered software slicing process, to form the corresponding code into the bone scaffold manufacturing apparatus, the height 0.5 mm is provided, the size of the extrusion line 1mm, the line spacing of 1.9_ extruded, the extrusion mechanism is a moving speed 15mm / s;

[0077] 3)控制板控制所有装置工作,起始位置如图6(a)所示,挤出机构和加热块都位于初始位置;接着如图6(b)所示,挤出机构在三维运动工作框架的作用下运动到设定的骨支架制造位置,由挤出机构将生物墨水喷射到位于正下方的工作台面上,加热单元根据制造的圆柱体支架结构的具体尺寸在其自身的三维运动平台作用下运动到相应位置,同时按照图5所示的加热温度控制图进行加热,当制造完一层骨支架结构时,温控单元和工作台面一起沿Z轴向下运动一层的距离,同时加热块在随后上移一段距离,给刚挤出来的支架结构进行加热,如图6(c)所示,循环往复,最后在工作台面上获得可控的Z方向长尺寸的三维骨支架结构,同时挤出机构和加热块都回到各自的初始位置,如图6(d)所示。 [0077] 3) the control panel for all the working devices, the starting position in FIG. 6 (a), the extrusion block and the heating means are located in an initial position; a three-dimensional 6 (b), the extrusion mechanism Next, as motion effect moving framework scaffold to the bone at a set position manufactured by extrusion mechanism to the ink jet biological positioned directly below the work surface, the heating unit depending on the size of the cylindrical support structure fabricated in its own three-dimensional motion effect moving the platform into position, while being heated according to a heating temperature control shown in FIG. 5, when manufacturing the finished layer of a bone scaffold, and the temperature control unit from the work surface along with the axial movement of the Z layer while heating block at some distance and then move on, to the freshly extruded stent structure to be heated, FIG. 6 (c), the cycle, finally obtained a controlled long dimension in the Z-direction three-dimensional bone scaffold countertop structure, and the heating means simultaneously extruded blocks are returned to their initial position, FIG. 6 (d) shown in FIG.

[0078] 4)把得到的支架结构在100 0C烘箱中干燥24小时,然后放到高温炉内高温1200 V保温3小时,最后炉内室温冷却得到骨支架结构,如图7所示。 [0078] 4) The resulting stent structure is dried in an oven at 100 0C for 24 hours and then placed in a high temperature furnace temperature 1200 V for 3 hours, and finally furnace cooled to room temperature to give bone scaffold structure, as shown in FIG.

Claims (10)

  1. 1.一种大尺寸骨支架制造装置,包括工作台面、挤出机构、驱动工作台面或挤出机构三维运动的工作框架以及温控单元,其特征在于:所述温控单元包括加热单元,以及驱动加热单元三维运动的运动平台;所述加热单元包括与所述运动平台固定的固定架以及设置在固定架上的加热块,该加热块围成对骨支架进行加热的工作空间。 An apparatus for producing large size bone scaffold, comprising a countertop, the extrusion mechanism, driven extruded countertop or the temperature control unit and a framework of three-dimensional movement mechanism, characterized in that: said temperature control unit comprises a heating unit, and motion platform driving of the heating unit of the three-dimensional movement; unit includes heating block and the motion platform and the fixed mount bracket provided on the heating, the heating block surrounding bone scaffold pair of work space heating.
  2. 2.根据权利要求1所述的大尺寸骨支架制造装置,其特征在于:还包括控制板,所述加热单元受控于该控制板;所述加热单元还包括检测骨支架周围环境温度的温度传感器,控制板采集该温度传感器的温度信号,根据温度信号大小实现对加热单元的控制。 The large size of the bone scaffold manufacturing apparatus as claimed in claim 1, characterized in that: further comprising a control panel, the heating unit is controlled by the control panel; said heating unit further includes a temperature detecting bone scaffold ambient temperature a temperature sensor signal, the temperature sensor acquisition board, the temperature control signal magnitude is achieved according to the heating unit.
  3. 3.根据权利要求1所述的大尺寸骨支架制造装置,其特征在于:所述固定架一端与运动平台安装固定,另一端设有U型或者半圆弧型的安装端;所述加热块固定在安装端内,呈U型或者半圆弧型布置。 The large size of the bone scaffold manufacturing apparatus as claimed in claim 1, wherein: one end of said bracket and fixed motion platform, the mounting end and the other end is provided with a U-shaped or semicircular arc; said heating block fixed in the mounting end, U-shaped or semicircular arc arrangement.
  4. 4.根据权利要求1所述的大尺寸骨支架制造装置,其特征在于:所述加热块为加热膜,加热线圈,加热板中的一种。 The large size of the bone scaffold manufacturing apparatus as claimed in claim 1, wherein: said heating block is a membrane heating, heating coils, heating plates.
  5. 5.根据权利要求1所述的大尺寸骨支架制造装置,其特征在于:所述加热块的厚度在3mm到15mm之间。 The large size of the bone scaffold manufacturing apparatus according to claim 1, wherein: the thickness of the heat block between 3mm and 15mm.
  6. 6.根据权利要求1所述的大尺寸骨支架制造装置,其特征在于:所述运动平台包括: 与工作台面固定第一水平轨道; 垂直滑动设置在第一水平轨道上的第二水平轨道; 竖直滑动设置在第二水平轨道上的Z轴轨道; 所述固定架通过滑块与Z轴轨道滑动设置。 The large size of the bone scaffold manufacturing apparatus as claimed in claim 1, wherein: said motion platform comprising: a first work surface and a fixed horizontal rail; second horizontal rails disposed vertically slidable in a first horizontal rail; vertical sliding track provided on the second level of the Z-axis rail; the fixture by the Z-axis slider rails slidably disposed.
  7. 7.一种大尺寸骨支架制造方法,其特征在于:采用权利要求1〜6任一项所述的大尺寸骨支架制造装置,包括以下步骤: (1)利用分层软件将需要制造的骨支架三维结构模型分层切片处理,形成相应代码; (2)根据代码,挤出机构将预先配置好的生物墨水喷射到位于正下方的工作台面上,加热单元同时在运动平台驱动下实时调整加热位置,工作面上获得Z方向长尺寸的三维骨支架结构; (3)把得到的骨支架结构在80〜120 0C烘箱中干燥20〜48小时,然后放到高温炉内高温1000〜1500°C保温2〜4小时,最后冷却得到骨支架结构。 A method for manufacturing a large-sized bone scaffold, comprising: using a large-sized bone claim stent manufacturing apparatus according to any one of claims 1~6, comprising the steps of: (1) the need to make use of layered software bone three-dimensional structural model of scaffold slicing process, to form the corresponding codes; (2) according to the code, the extrusion mechanism preconfigured biological located directly below the ink onto the work surface, while real-time adjustment of the heating the heating unit in the moving platform driven position, the work surface in the Z direction to obtain a three-dimensional structure of the bone scaffold long dimension; (3) the structure of the bone scaffold obtained was dried in an oven 80~120 0C 20~48 hours, and then placed in a high temperature furnace temperature 1000~1500 ° C incubated 2 ~ 4 hours, and finally cooled to give a bone scaffold.
  8. 8.根据权利要求7所述的大尺寸骨支架制造方法,其特征在于:所述三维骨支架结构为柱形结构;所述固定架一端与运动平台安装固定,另一端设有U型或者半圆弧型的安装端;所述加热块固定在安装端内,呈U型或者半圆弧型布置;所述三维骨支架结构设置在加热块中心位置。 8. A method of manufacturing a large-sized bone scaffold according to claim 7, wherein: the three-dimensional structure is a columnar structure of the bone scaffold; end of the holder with the motion platform fixed, the other end is provided with a U-shaped or semi- arc mounting ends; said heater block is mounted in the mounting end is U-shaped or semicircular arc disposed; the three-dimensional structure of the bone scaffold center position is provided in a heating block.
  9. 9.根据权利要求7所述的大尺寸骨支架制造方法,其特征在于:所述生物墨水为水凝胶溶液和粉体的混合物; 所述水凝胶溶液为PVA水凝胶溶液、CMC水凝胶溶液、PEG水凝胶溶液中的一种或几种混合; 所述粉体可以是硅酸盐、磷酸盐、生物玻璃中的一种或几种的混合,其粒径在I到10微米之间。 9. A method of manufacturing a large-sized bone scaffold according to claim 7, wherein: said ink is a mixture of biological hydrogel solution and powder; the hydrogel solution is a solution of PVA hydrogels, the CMC water gel solution, mixed with one or more PEG hydrogel solution; the powder may be mixed silicate, phosphate, bioglass of one or more of a particle size in the 10 to I between microns.
  10. 10.根据权利要求9所述的大尺寸骨支架制造方法,其特征在于:所述大尺寸骨支架制造装置为权利要求2所述的大尺寸骨支架制造装置;所述温度传感器对环境温度进行检测,把检测到的温度实时传输给控制板; 如果检测到的温度低于控制板设定的温度,则控制板输出控制信号给加热块,加热块继续加热; 如果检测到的检测到温度达到或低于设定温度时,控制板继续进行判断: 如果在设定时间内,设定温度与检测到的温度差值小于等于设定值,则控制加热块停止工作; 如果在设定时间内,设定温度与检测到的温度差值大于设定值,降低加热块的功率,控制板继续控制加热块工作。 10. A method of manufacturing a large size of the bone holder according to claim 9, wherein: said means for producing a large-sized bone scaffold large size bone stent manufacturing apparatus according to claim 2; the temperature sensor of ambient temperature detection, the real-time transmission of the detected temperature to the control panel; if the detected temperature is lower than the set temperature of the control board, the control board outputs a control signal to the heating block, heating was continued heating block; is detected if the detected temperature reaches when or below the set temperature, the control board is determined to continue: if the temperature difference within the set time, set temperature and the detected set value or less, the control stops heating block; if within the set time , the temperature difference between the set temperature and the detected than the set value, reducing power to the heating block, the heating block control panel continues to work.
CN 201610102050 2016-02-24 2016-02-24 One kind of a large-sized bone stent manufacturing apparatus and manufacturing method thereof CN105751501B (en)

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