CN105749063A - 治疗肾虚崩漏的中药速溶颗粒及其制备方法 - Google Patents

治疗肾虚崩漏的中药速溶颗粒及其制备方法 Download PDF

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CN105749063A
CN105749063A CN201610265657.XA CN201610265657A CN105749063A CN 105749063 A CN105749063 A CN 105749063A CN 201610265657 A CN201610265657 A CN 201610265657A CN 105749063 A CN105749063 A CN 105749063A
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秦朝东
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Abstract

本发明公开了一种治疗肾虚崩漏的中药速溶颗粒及其制备方法，本发明对以下重量份的原来进行浸提：当归812、太子参812、白芍812、焦白术810、三七46、山药1825、人参24、棕榈炭812、艾叶炭58、炒麦芽812、炒山楂812、炒杜仲46、香附46、炙黄芪1218、益母草810、桑寄生46、骨碎补58、鹿角胶13、菟丝子812、五味子46、地榆炭1015、玫瑰花4060及月季花4060。

Description

治疗肾虚崩漏的中药速溶颗粒及其制备方法
技术领域
本发明涉及速溶颗粒加工技术领域，尤其涉及一种治疗肾虚崩漏的中药速溶颗粒及其制备方法。
背景技术
崩漏，中医病名，西医的功能性子宫出血所出现的阴道出血，属崩漏范畴，是月经的周期、经期、经量发生严重失常的病证，其发病急骤，暴下如注，大量出血者为“崩”；病势缓，出血量少，淋漓不绝者为“漏”。崩与漏虽出血情况不同，但在发病过程中两者常互相转化，如崩血量渐少，可能转化为漏，漏势发展又可能变为崩，故临床多以崩漏并称。
崩漏可发生在月经初潮后至绝经的任何年龄，足以影响生育，危害健康。属妇科常见病，也是疑难急重病证。汉代《金匮要略.妇人妊娠病脉证并治》首先提出“漏下”之名和宿有症病，又兼受孕，症痼害胎下血流不止，以及瘀阻冲任、子宫之病机、治法及方药。又在《金匮要略·妇人妊娠病脉证并治》中指出妇人年五十，病下血数十日不止，温经汤主之，是冲任虚寒兼瘀热互结导致更年期崩漏的证治。《内经》论崩和《金贵要略》论漏下，为后世研究崩漏奠定了基础。
中医上认为引起崩漏的原因有多种，例如：脾虚血失统摄，甚则需而下陷，冲任不固，不能制约经血，发为崩漏；热伤冲任，迫血妄行，发为崩漏；瘀阻冲任、子宫，血不归经而妄行，遂成崩漏。此外，先天肾气不足，或少女肾气未盛，天癸未充，或房劳多产损伤肾气，或久病大病穷必及肾，或七七之年肾气渐衰，天癸渐竭，肾气虚则封藏失司，冲任不固，不能制约经血，即肾虚崩漏。目前，由于多种原因，对于肾虚崩漏的治疗效果不尽理想。
西医治疗崩漏需排除生殖器肿瘤、炎症或全身性疾病(如再生障碍性贫血等)引起的阴道出血，往往应用一些抗生素药物进行治疗，副作用较大，且往往治标不治本，易复发，难以根治。
目前，还没有中药成分的可有效治疗肾虚崩漏的保健药品，尤其是可有效治疗崩漏的中药速溶颗粒。
发明内容
本发明针对现有技术中存在的上述问题，提供一种治疗肾虚崩漏的中药组合物，能够有效治疗肾虚崩漏，无副作用。
为实现上述目的，本发明采用如下技术方案：
一种治疗肾虚崩漏的中药速溶颗粒，包含以下重量份的原料：
当归8-12、太子参8-12、白芍8-12、焦白术8-10、三七4-6、山药18-25、人参2-4、棕榈炭8-12、艾叶炭5-8、炒麦芽8-12、炒山楂8-12、炒杜仲4-6、香附4-6、炙黄芪12-18、益母草8-10、桑寄生4-6、骨碎补5-8、鹿角胶1-3、菟丝子8-12、五味子4-6、地榆炭10-15、玫瑰花40-60及月季花40-60。
优选的是，所述的治疗肾虚崩漏的中药速溶颗粒中，包含以下重量份的原料：当归10、太子参10、白芍10、焦白术9、三七5、山药20、人参3、棕榈炭10、艾叶炭6、炒麦芽10、炒山楂10、炒杜仲5、香附5、炙黄芪15、益母草9、桑寄生5、骨碎补6、鹿角胶2、菟丝子10、五味子5、地榆炭12、玫瑰花50及月季花50。
一种治疗肾虚崩漏的中药速溶颗粒的制备方法，包括以下步骤：
步骤一、浸提，将所述原料与5-6倍体积的水混合后，在温度35-48℃下浸提40-50min，过滤，得到一次滤渣及一次浸提液；将所得一次滤渣与2-3倍体积的水混合后，在温度68-72℃下浸提20-30min，过滤，得到二次滤渣及二次浸提液；将所得二次滤渣与2-3倍体积的水混合，在温度80-90℃下浸提20-30分钟，过滤，得到三次滤渣及三次浸提液；
步骤二、混合浓缩，将一次浸提液、二次浸提液以及三次浸提液混合后进行真空浓缩，得到混合浓缩液；
步骤三、喷雾干燥，将所得混合浓缩液进行喷雾干燥，既得所述治疗肾虚崩漏的中药速溶颗粒。
优选的是，所述的治疗肾虚崩漏的中药速溶颗粒的制备方法中，步骤三中在进行喷雾干燥之前将混合浓缩液的浓度调节为25-28％，并控制喷雾干燥后的治疗肾虚崩漏的中药速溶颗粒的总水分含量为2-3％。
本发明具有以下有益效果：本发明利用中医五行及辨证理论，认为肾虚崩漏的病因为：欲念不遂，情志积郁，心脾气结，致伤冲任之源，而肾气日消不能固摄经水，崩漏渐成。治宜补脾胃以资血之源、养肾气以安血固经。本发明中，当归，破恶血、养新血；太子参，补益脾肺；白芍，养血柔肝；焦白术，健脾胃、补元气；三七，化瘀止血；山药，健脾胃、补气血；人参，补肾气、健脾胃；棕榈炭，收敛止血；艾叶炭，温经止血；炒麦芽、炒山楂，健脾助消食；炒杜仲，补肝肾、止血；香附，疏理肝郁之气；炙黄芪，补气血、升举阳气；益母草，活血祛瘀；桑寄生，补肝肾、养血；骨碎补，补肾、活血、止血；鹿角胶，补肝肾、益精血、止血；菟丝子，补阳益阴、固元气；五味子，敛肺滋肾、宁心安神；地榆炭，收敛止血。本发明将以上多种中药合理配伍，补脾胃、养肾气，使肾虚崩漏得以治愈，与玫瑰花、月季花进行复配，制备为速溶颗粒，提取率高，服用方便，口感好。本发明所述中药速溶颗粒提取率大于40％，每日取10-20g速溶颗粒用40℃以上的温水冲调，可迅速溶解，溶液清澈透明，适宜直接饮用，可有效治疗肾虚崩漏。
具体实施方式
下面对本发明做详细说明，以令本领域普通技术人员参阅本说明书后能够据以实施。
一种治疗肾虚崩漏的中药速溶颗粒，包含以下重量份的原料：
当归8-12、太子参8-12、白芍8-12、焦白术8-10、三七4-6、山药18-25、人参2-4、棕榈炭8-12、艾叶炭5-8、炒麦芽8-12、炒山楂8-12、炒杜仲4-6、香附4-6、炙黄芪12-18、益母草8-10、桑寄生4-6、骨碎补5-8、鹿角胶1-3、菟丝子8-12、五味子4-6、地榆炭10-15、玫瑰花40-60及月季花40-60。
本发明利用中医五行及辨证理论，认为肾虚崩漏的病因为：欲念不遂，情志积郁，心脾气结，致伤冲任之源，而肾气日消不能固摄经水，崩漏渐成。治宜补脾胃以资血之源、养肾气以安血固经。本发明中，当归，破恶血、养新血；太子参，补益脾肺；白芍，养血柔肝；焦白术，健脾胃、补元气；三七，化瘀止血；山药，健脾胃、补气血；人参，补肾气、健脾胃；棕榈炭，收敛止血；艾叶炭，温经止血；炒麦芽、炒山楂，健脾助消食；炒杜仲，补肝肾、止血；香附，疏理肝郁之气；炙黄芪，补气血、升举阳气；益母草，活血祛瘀；桑寄生，补肝肾、养血；骨碎补，补肾、活血、止血；鹿角胶，补肝肾、益精血、止血；菟丝子，补阳益阴、固元气；五味子，敛肺滋肾、宁心安神；地榆炭，收敛止血。本发明将以上多种中药合理配伍，补脾胃、养肾气，使肾虚崩漏得以治愈，与玫瑰花、月季花进行复配，制备为速溶颗粒，提取率高，服用方便，口感好。本发明所述中药速溶颗粒提取率大于40％，每日取10-20g速溶颗粒用40℃以上的温水冲调，可迅速溶解，溶液清澈透明，适宜直接饮用，可有效治疗肾虚崩漏
一种治疗肾虚崩漏的中药速溶颗粒的制备方法，包括以下步骤：
步骤一、浸提，将所述原料与5-6倍体积的水混合后，在温度35-48℃下浸提40-50min，过滤，得到一次滤渣及一次浸提液；将所得一次滤渣与2-3倍体积的水混合后，在温度68-72℃下浸提20-30min，过滤，得到二次滤渣及二次浸提液；将所得二次滤渣与2-3倍体积的水混合，在温度80-90℃下浸提20-30分钟，过滤，得到三次滤渣及三次浸提液；
步骤二、混合浓缩，将一次浸提液、二次浸提液以及三次浸提液混合后进行真空浓缩，得到混合浓缩液；
步骤三、喷雾干燥，将所得混合浓缩液进行喷雾干燥，既得所述治疗肾虚崩漏的中药速溶颗粒。
所述的治疗肾虚崩漏的中药速溶颗粒的制备方法中，步骤三中在进行喷雾干燥之前将混合浓缩液的浓度调节为25-28％，并控制喷雾干燥后的治疗肾虚崩漏的中药速溶颗粒的总水分含量为2-3％。
本发明所述中药颗粒粉提取率大于40％，每日取10-20g颗粒粉在用40℃以上的温水冲调，可迅速溶解，溶液清澈透明，适宜直接饮用，可有效治疗肾虚崩漏。
实施例1
一种治疗肾虚崩漏的中药速溶颗粒，包含以下重量份的原料：当归10、太子参10、白芍10、焦白术9、三七5、山药20、人参3、棕榈炭10、艾叶炭6、炒麦芽10、炒山楂10、炒杜仲5、香附5、炙黄芪15、益母草9、桑寄生5、骨碎补6、鹿角胶2、菟丝子10、五味子5、地榆炭12、玫瑰花50及月季花50。
步骤一、浸提，将所述原料与5倍体积的水混合后，在温度40℃下浸提40min，过滤，得到一次滤渣及一次浸提液；将所得一次滤渣与2倍体积的水混合后，在温度70℃下浸提25min，过滤，得到二次滤渣及二次浸提液；将所得二次滤渣与2倍体积的水混合，在温度80℃下浸提20分钟，过滤，得到三次滤渣及三次浸提液；
步骤二、混合浓缩，将一次浸提液、二次浸提液以及三次浸提液混合后进行真空浓缩，得到混合浓缩液；
步骤三、喷雾干燥，将所得混合浓缩液进行喷雾干燥，既得所述治疗肾虚崩漏的中药速溶颗粒。
所述的治疗肾虚崩漏的中药速溶颗粒的制备方法中，步骤三中在进行喷雾干燥之前将混合浓缩液的浓度调节为25％，并控制喷雾干燥后的治疗肾虚崩漏的中药速溶颗粒的总水分含量为2％。
每日取15g可所述速溶颗粒，50℃温水冲调饮用。
实施例2
一种治疗肾虚崩漏的中药速溶颗粒，包含以下重量份的原料：当归12、太子参12、白芍12、焦白术10、三七6、山药22、人参5、棕榈炭12、艾叶炭5、炒麦芽12、炒山楂12、炒杜仲6、香附6、炙黄芪16、益母草10、桑寄生6、骨碎补5、鹿角胶3、菟丝子12、五味子6、地榆炭14、玫瑰花60及月季花60。
步骤一、浸提，将所述原料与6倍体积的水混合后，在温度45℃下浸提50min，过滤，得到一次滤渣及一次浸提液；将所得一次滤渣与3倍体积的水混合后，在温度75℃下浸提30min，过滤，得到二次滤渣及二次浸提液；将所得二次滤渣与3倍体积的水混合，在温度85℃下浸提30分钟，过滤，得到三次滤渣及三次浸提液；
步骤二、混合浓缩，将一次浸提液、二次浸提液以及三次浸提液混合后进行真空浓缩，得到混合浓缩液；
步骤三、喷雾干燥，将所得混合浓缩液进行喷雾干燥，既得所述治疗肾虚崩漏的中药速溶颗粒。
所述的治疗肾虚崩漏的中药速溶颗粒的制备方法中，步骤三中在进行喷雾干燥之前将混合浓缩液的浓度调节为28％，并控制喷雾干燥后的治疗肾虚崩漏的中药速溶颗粒的总水分含量为2.5％。
每日取20g可所述速溶颗粒，40℃温水冲调饮用。
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本发明的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节。

Claims (4)

1.一种治疗肾虚崩漏的中药速溶颗粒，其特征在于，包含以下重量份的原料：
当归8-12、太子参8-12、白芍8-12、焦白术8-10、三七4-6、山药18-25、人参2-4、棕榈炭8-12、艾叶炭5-8、炒麦芽8-12、炒山楂8-12、炒杜仲4-6、香附4-6、炙黄芪12-18、益母草8-10、桑寄生4-6、骨碎补5-8、鹿角胶1-3、菟丝子8-12、五味子4-6、地榆炭10-15、玫瑰花40-60及月季花40-60。
2.如权利要求1所述的治疗肾虚崩漏的中药速溶颗粒，其特征在于，包含以下重量份的原料：当归10、太子参10、白芍10、焦白术9、三七5、山药20、人参3、棕榈炭10、艾叶炭6、炒麦芽10、炒山楂10、炒杜仲5、香附5、炙黄芪15、益母草9、桑寄生5、骨碎补6、鹿角胶2、菟丝子10、五味子5、地榆炭12、玫瑰花50及月季花50。
3.一种如权利要求1或2所述的治疗肾虚崩漏的中药速溶颗粒的制备方法，其特征在于，包括以下步骤：
步骤一、浸提，将所述原料与5-6倍体积的水混合后，在温度35-48℃下浸提40-50min，过滤，得到一次滤渣及一次浸提液；将所得一次滤渣与2-3倍体积的水混合后，在温度68-72℃下浸提20-30min，过滤，得到二次滤渣及二次浸提液；将所得二次滤渣与2-3倍体积的水混合，在温度80-90℃下浸提20-30分钟，过滤，得到三次滤渣及三次浸提液；
步骤二、混合浓缩，将一次浸提液、二次浸提液以及三次浸提液混合后进行真空浓缩，得到混合浓缩液；
步骤三、喷雾干燥，将所得混合浓缩液进行喷雾干燥，既得所述治疗肾虚崩漏的中药速溶颗粒。
4.如权利要求3所述的治疗肾虚崩漏的中药速溶颗粒的制备方法，其特征在于，步骤三中在进行喷雾干燥之前将混合浓缩液的浓度调节为25-28％，并控制喷雾干燥后的治疗肾虚崩漏的中药速溶颗粒的总水分含量为2-3％。
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Application publication date: 20160713