CN105748428B - A kind of preparation method of peace stomach ulcer dispersible tablet - Google Patents
A kind of preparation method of peace stomach ulcer dispersible tablet Download PDFInfo
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- CN105748428B CN105748428B CN201511011086.9A CN201511011086A CN105748428B CN 105748428 B CN105748428 B CN 105748428B CN 201511011086 A CN201511011086 A CN 201511011086A CN 105748428 B CN105748428 B CN 105748428B
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- stomach ulcer
- dispersible tablet
- peace stomach
- peace
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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Abstract
The present invention discloses a kind of preparation method of peace stomach ulcer dispersible tablet, includes the following steps：S1. peace stomach ulcer and beta-cyclodextrin are added separately in 1% sodium bicarbonate solution, break-in is carried out using colloid mill, it is dry, obtain inclusion compound；S2. inclusion compound, PPVP, microcrystalline cellulose, stevioside, calcium monohydrogen phosphate and 5% PVP K30 solution are granulated, obtain uncoated peace stomach ulcer dispersible tablet；S3. HPMC, crosslinked carboxymethyl fecula sodium, acrylic resin, glycerine, magnesium stearate, white pigment and crospovidone are mixed to form coating solution, to the uncoated peace stomach ulcer dispersible tablet obtained by S2 be coated to get.The peace stomach ulcer dispersible tablet obtained through the invention is suitble to the use of dispersible tablet, has the advantages that dissolution is fast, rapid-action.
Description
Technical field
The present invention relates to dispersible tablets of traditional Chinese medicine fields, more particularly, to a kind of preparation method of peace stomach ulcer dispersible tablet.
Background technology
Dispersible tablet (dispersible tablet) refers to being disintegrated rapidly in water and evenly dispersed tablet.Chinese medicine disperses
Piece be exactly using Chinese medical extract, Chinese medicinal raw powder or refined intermediate as raw material, can be rapid in water in addition made of proper auxiliary materials
It is disintegrated evenly dispersed tablet.
Pacify gastric ulcer capsule, tonifying middle-Jiao and Qi solves taking poison and growing muscle due.Cure mainly stomach and duodenal bulbar ulcer.To asthenic cold type and the stagnation of the circulation of vital energy
Type patient has a better effect.And it can be used for the maintaining treatment after ulcer healing.Peace stomach ulcer is fabricated to dispersible tablet, can increase its life
Object availability, and the quick release in stomach, renovating tummy mucous membrane reach quick-acting, the effect of relieving spasm to stop pain.Since dispersible tablets of traditional Chinese medicine is general
Store-through is in the effect of dispersing uniformity effect difference, therefore dispersible tablet is still less in general Chinese medicine preparation.
Invention content
An object of the present invention is to make a kind of dispersible tablet system that suitable peace stomach ulcer uses.
According to goal of the invention, the present invention provides a kind of preparation method of peace stomach ulcer dispersible tablet, includes the following steps
S1. peace stomach ulcer and cycloheptaamylose are added separately in 1% sodium bicarbonate solution, are ground using colloid mill
It closes, it is dry, obtain inclusion compound；
S2. inclusion compound, PPVP, microcrystalline cellulose, stevioside, calcium monohydrogen phosphate and 5% PVP K30 solution are made
Grain, obtains uncoated peace stomach ulcer dispersible tablet；
S3. HPMC, crosslinked carboxymethyl fecula sodium, acrylic resin, glycerine, magnesium stearate, white pigment and crosslinking is poly-
Dimension ketone be mixed to form coating solution, to the uncoated peace stomach ulcer dispersible tablet obtained by S2 be coated to get.
Peace stomach ulcer, cycloheptaamylose and 1% sodium bicarbonate solution, remembers by weight, respectively 1 part, 1 ~ 3 part and 4
~ 6 parts.
Break-in described in S1 is flowing shape break-in 30 ~ 50 minutes.
The present invention has the following advantages：
1. peace stomach ulcer is changed to dispersible tablet from capsule, peace stomach ulcer fater disintegration in gastric juice is set to form Radix Glycyrrhizae yellow
Ketone dispersed phase, adheres to stomach wall, the effect of playing the role of protecting stomach lining and renovating tummy mucous membrane, there is class Targeting delivery.
2. the present invention by weakly alkaline solution, considerably increases the solubility of peace stomach ulcer, to be included with liquid
Object greatly improves the inclusion efficiency of peace stomach ulcer.
3. adding crospovidone in coating solution, increases the water sucting degree of coating membrane material, accelerates its water swelling,
The channel that moisture enters is formed, after moisture content enters label, label crospovidone quickly absorbs moisture, and the peace after β-cdinclusion
Stomach ulcer inclusion compound reduces the bridging action power between traditional Chinese medicine extraction powder because changing the bridge formation between licoflavone powder, because
After this piece wicking absorbent, can fater disintegration leach.
Specific implementation mode
With reference to specific embodiment, present invention be described in more detail.Reagent that unless stated otherwise, the present invention uses,
Device and method are reagent, equipment and the conventional use of method of the art regular market purchase.
Embodiment 1
A kind of preparation method of peace stomach ulcer dispersible tablet, includes the following steps
S1. remember by weight, 2 parts of 1 part of peace stomach ulcer and cycloheptaamylose are added separately to 5 part of 1% sodium bicarbonate solution
In, break-in is carried out using colloid mill, it is dry, obtain inclusion compound；
S2. remember by weight, by 1 part of inclusion compound, PPVP0.03 parts, 0.2 part of microcrystalline cellulose, 0.02 part of stevioside, phosphorus
0.1 part of sour hydrogen calcium is added in 5% PVP K30 solution and is granulated, and obtains uncoated peace stomach ulcer dispersible tablet；
S3. HPMC, crosslinked carboxymethyl fecula sodium, acrylic resin, glycerine, magnesium stearate, white pigment and crosslinking is poly-
Dimension ketone be mixed to form coating solution, to the uncoated peace stomach ulcer dispersible tablet obtained by S2 be coated to get.
Embodiment 2
A kind of preparation method of peace stomach ulcer dispersible tablet, includes the following steps
S1. remember by weight, 1 part of 1 part of peace stomach ulcer and cycloheptaamylose are added separately to 4 part of 1% sodium bicarbonate solution
In, break-in is carried out using colloid mill, it is dry, obtain inclusion compound；
S2. remember by weight, by 1 part of inclusion compound, PPVP0.03 parts, 0.2 part of microcrystalline cellulose, 0.02 part of stevioside, phosphorus
0.1 part of sour hydrogen calcium is added in 5% PVP K30 solution and is granulated, and obtains uncoated peace stomach ulcer dispersible tablet；
S3. HPMC, crosslinked carboxymethyl fecula sodium, acrylic resin, glycerine, magnesium stearate, white pigment and crosslinking is poly-
Dimension ketone be mixed to form coating solution, to the uncoated peace stomach ulcer dispersible tablet obtained by S2 be coated to get.
Embodiment 3
A kind of preparation method of peace stomach ulcer dispersible tablet, includes the following steps
S1. remember by weight, 3 parts of 1 part of peace stomach ulcer and cycloheptaamylose are added separately to 6 part of 1% sodium bicarbonate solution
In, break-in is carried out using colloid mill, it is dry, obtain inclusion compound；
S2. remember by weight, by 1 part of inclusion compound, PPVP0.03 parts, 0.2 part of microcrystalline cellulose, 0.02 part of stevioside, phosphorus
0.1 part of sour hydrogen calcium is added in 5% PVP K30 solution and is granulated, and obtains uncoated peace stomach ulcer dispersible tablet；
S3. HPMC, crosslinked carboxymethyl fecula sodium, acrylic resin, glycerine, magnesium stearate, white pigment and crosslinking is poly-
Dimension ketone be mixed to form coating solution, to the uncoated peace stomach ulcer dispersible tablet obtained by S2 be coated to get.
Claims (4)
1. a kind of preparation method of peace stomach ulcer dispersible tablet, which is characterized in that include the following steps：
S1. by weight, 2 parts of 1 part of peace stomach ulcer and cycloheptaamylose are added separately in 5 part of 1% sodium bicarbonate solution,
Break-in is carried out using colloid mill, it is dry, obtain inclusion compound；
S2. by weight, by 1 part of inclusion compound, PPVP0.03 parts, 0.2 part of microcrystalline cellulose, 0.02 part of stevioside, phosphoric acid
0.1 part of hydrogen calcium is added in 5% PVP K30 solution and is granulated, and obtains uncoated peace stomach ulcer dispersible tablet；
S3. by HPMC, crosslinked carboxymethyl fecula sodium, acrylic resin, glycerine, magnesium stearate, white pigment and crospovidone
Be mixed to form coating solution, to the uncoated peace stomach ulcer dispersible tablet obtained by S2 be coated to get.
2. a kind of preparation method of peace stomach ulcer dispersible tablet, which is characterized in that include the following steps：
S1. by weight, 1 part of 1 part of peace stomach ulcer and cycloheptaamylose are added separately in 4 part of 1% sodium bicarbonate solution,
Break-in is carried out using colloid mill, it is dry, obtain inclusion compound；
S2. by weight, by 1 part of inclusion compound, PPVP0.03 parts, 0.2 part of microcrystalline cellulose, 0.02 part of stevioside, phosphoric acid
0.1 part of hydrogen calcium is added in 5% PVP K30 solution and is granulated, and obtains uncoated peace stomach ulcer dispersible tablet；
S3. by HPMC, crosslinked carboxymethyl fecula sodium, acrylic resin, glycerine, magnesium stearate, white pigment and crospovidone
Be mixed to form coating solution, to the uncoated peace stomach ulcer dispersible tablet obtained by S2 be coated to get.
3. a kind of preparation method of peace stomach ulcer dispersible tablet, which is characterized in that include the following steps：
S1. by weight, 3 parts of 1 part of peace stomach ulcer and cycloheptaamylose are added separately in 6 part of 1% sodium bicarbonate solution,
Break-in is carried out using colloid mill, it is dry, obtain inclusion compound；
S2. by weight, by 1 part of inclusion compound, PPVP0.03 parts, 0.2 part of microcrystalline cellulose, 0.02 part of stevioside, phosphoric acid
0.1 part of hydrogen calcium is added in 5% PVP K30 solution and is granulated, and obtains uncoated peace stomach ulcer dispersible tablet；
S3. by HPMC, crosslinked carboxymethyl fecula sodium, acrylic resin, glycerine, magnesium stearate, white pigment and crospovidone
Be mixed to form coating solution, to the uncoated peace stomach ulcer dispersible tablet obtained by S2 be coated to get.
4. according to the preparation method of any peace stomach ulcer dispersible tablet of claim 1 ~ 3, which is characterized in that the break-in described in S1
For flowing shape break-in 30 ~ 50 minutes.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511011086.9A CN105748428B (en) | 2015-12-30 | 2015-12-30 | A kind of preparation method of peace stomach ulcer dispersible tablet |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511011086.9A CN105748428B (en) | 2015-12-30 | 2015-12-30 | A kind of preparation method of peace stomach ulcer dispersible tablet |
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| Publication Number | Publication Date |
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| CN105748428A CN105748428A (en) | 2016-07-13 |
| CN105748428B true CN105748428B (en) | 2018-08-24 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101347495A (en) * | 2007-07-16 | 2009-01-21 | 兰州大学 | Preparation of Glabridin dispersible tablets and use of the tablets in reducing blood sugar as medicament active composition |
| CN102000179A (en) * | 2010-11-09 | 2011-04-06 | 承德颈复康药业集团有限公司 | New stomachic core coated tablet and preparation method thereof |
| CN103446238A (en) * | 2012-06-01 | 2013-12-18 | 贵州百灵企业集团制药股份有限公司 | Medicament for treating dysmenorrhea and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012100408A1 (en) * | 2011-01-25 | 2012-08-02 | 河北以岭医药研究院有限公司 | Dextrin inclusion complex, preparation method thereof and pharmaceutical formulation comprising said inclusion complex |
-
2015
- 2015-12-30 CN CN201511011086.9A patent/CN105748428B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101347495A (en) * | 2007-07-16 | 2009-01-21 | 兰州大学 | Preparation of Glabridin dispersible tablets and use of the tablets in reducing blood sugar as medicament active composition |
| CN102000179A (en) * | 2010-11-09 | 2011-04-06 | 承德颈复康药业集团有限公司 | New stomachic core coated tablet and preparation method thereof |
| CN103446238A (en) * | 2012-06-01 | 2013-12-18 | 贵州百灵企业集团制药股份有限公司 | Medicament for treating dysmenorrhea and preparation method thereof |
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| CN105748428A (en) | 2016-07-13 |
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Effective date of registration: 20210831 Address after: 516000 office building of Henan an Dalang Du Jiuhui Pharmaceutical Co., Ltd., Huizhou City, Guangdong Province Patentee after: Huizhou Jiuhui Pharmaceutical Co.,Ltd. Address before: 516007 No. 199 Nan'an Road, Huizhou City, Guangdong Province Patentee before: JIUHUI PHARMACEUTICAL Co.,Ltd. |