CN105748406A - A procaine penicillin G oil suspension injection for veterinary use and a preparing method thereof - Google Patents
A procaine penicillin G oil suspension injection for veterinary use and a preparing method thereof Download PDFInfo
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- CN105748406A CN105748406A CN201410793206.4A CN201410793206A CN105748406A CN 105748406 A CN105748406 A CN 105748406A CN 201410793206 A CN201410793206 A CN 201410793206A CN 105748406 A CN105748406 A CN 105748406A
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- injection
- neoproc
- oil
- butylated hydroxyanisole
- suspension injection
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Abstract
A procaine penicillin G oil suspension injection for veterinary use and a preparing method thereof are disclosed. Each 100 mL of the injection comprises 20 million to 40 million IU of procaine penicillin G, 0.01-0.04 g of butylated hydroxyanisole and 0.2-0.6 g of aluminum tristearate, with the balance being oil used for injections. By utilizing suspending and dispersing effects of the butylated hydroxyanisole and the aluminum tristearate, a prepared product of the injection is stable in properties, good in redispersibility, reliable in quality, safe and effective.
Description
Technical field
The invention belongs to veterinary drug field of pharmaceutical technology, be specifically related to a kind of neoproc oil preparation suspension injection for animals and preparation method thereof.
Background technology
Penicillin belongs to bactericidal antibiotic, and antibacterial activity is strong, and its Antibacterial mechanism mainly suppresses the synthesis that bacteria cell wall is mucopeptide.The sensitive organism division of trophophase is vigorous, and cell wall is in the biosynthesis phase, and under the effect of penicillin, mucopeptide biosynthesis block can not form cell wall, causes membranolysis and dead under osmotic pressure effect.Penicillin is a narrow-spectrum antibiotic, mainly multiple gram positive bacteria and minority Gram-negative coccus there is effect, sensitive prime bacterium has staphylococcus, streptococcus, bacillus rhusiopathiae suis, corynebacterium, clostridium tetani, actinomycetes, anthrax bacillus, spirillum etc., and mycobacterium, mycoplasma, chlamydia, rickettsia, Nocardia, fungus and virus bacterium is insensitive.
Benzylpenicillin is because half-life short Metabolism Excretion is fast, so benzylpenicillin effective drug duration is short, needs multiple dosing for reaching therapeutic effect during clinical treatment.Neoproc is benzathine penicillin, well makes up this shortcoming of benzylpenicillin.
Summary of the invention
In view of this, it is an object of the invention to provide a kind of neoproc oil preparation suspension injection for animals and preparation method thereof, neoproc is made stable in properties, oil preparation suspension injection that redispersibility is good.
For reaching above-mentioned purpose, the present invention provides following technical scheme:
The neoproc oil preparation suspension injection for animals of the present invention, every 100mL injection is composed of the following components:
Neoproc 20 ~ 40,000,000 IU；
Butylated hydroxyanisole 0.01 ~ 0.04g；
Aluminium Tristearate Micronized sterile 0.2 ~ 0.6g；
Surplus is oil for injection.
The optimization formula of the neoproc oil preparation suspension injection for animals of the present invention, every 100mL injection is composed of the following components:
Neoproc 30,000,000 IU；
Butylated hydroxyanisole 0.02g；
Aluminium Tristearate Micronized sterile 0.4g；
Surplus is oil for injection.
The preparation method of the neoproc oil preparation suspension injection for animals of the present invention, comprises the following steps:
(1) Aluminium Tristearate Micronized sterile accurately weighing recipe quantity adds in oil for injection, and heated and stirred is dissolved；
(2) after Aluminium Tristearate Micronized sterile is completely dissolved, standing lets cool, and slowly topples over, and discards visible foreign；
(3) add after the Butylated hydroxyanisole of recipe quantity being dissolved with oil for injection in the system of step (2), add the neoproc of recipe quantity while stirring, use oil for injection constant volume；
(4) cross homogenizer after the system of step (3) being stirred, obtain neoproc oil preparation suspension injection.
The beneficial effects of the present invention is:
The present invention utilizes the suspending of Butylated hydroxyanisole and Aluminium Tristearate Micronized sterile to disperse, and the neoproc oil preparation suspension injection product property of preparation is stable, redispersibility good, and reliable in quality, safely, effectively.
Detailed description of the invention
The preferred embodiments of the present invention will be described in detail below.
Embodiment 1
The neoproc oil preparation suspension injection for animals of the present embodiment, every 100mL injection is composed of the following components:
Neoproc 30,000,000 IU；
Butylated hydroxyanisole 0.02g；
Aluminium Tristearate Micronized sterile 0.4g；
Surplus is oil for injection.
The preparation method of the neoproc oil preparation suspension injection for animals of the present embodiment, comprises the following steps:
(1) Aluminium Tristearate Micronized sterile accurately weighing recipe quantity adds in oil for injection, and heated and stirred is dissolved；
(2) after Aluminium Tristearate Micronized sterile is completely dissolved, standing lets cool, and slowly topples over, and discards visible foreign；
(3) add after the Butylated hydroxyanisole of recipe quantity being dissolved with oil for injection in the system of step (2), add the neoproc of recipe quantity while stirring, use oil for injection constant volume；
(4) cross homogenizer after the system of step (3) being stirred, obtain neoproc oil preparation suspension injection.
Embodiment 2
The neoproc oil preparation suspension injection for animals of the present embodiment, every 100mL injection is composed of the following components:
Neoproc 20,000,000 IU；
Butylated hydroxyanisole 0.01g；
Aluminium Tristearate Micronized sterile 0.3g；
Surplus is oil for injection.
The preparation method of the neoproc oil preparation suspension injection for animals of the present embodiment, comprises the following steps:
(1) Aluminium Tristearate Micronized sterile accurately weighing recipe quantity adds in oil for injection, and heated and stirred is dissolved；
(2) after Aluminium Tristearate Micronized sterile is completely dissolved, standing lets cool, and slowly topples over, and discards visible foreign；
(3) add after the Butylated hydroxyanisole of recipe quantity being dissolved with oil for injection in the system of step (2), add the neoproc of recipe quantity while stirring, use oil for injection constant volume；
(4) cross homogenizer after the system of step (3) being stirred, obtain neoproc oil preparation suspension injection.
Embodiment 3
The neoproc oil preparation suspension injection for animals of the present embodiment, every 100mL injection is composed of the following components:
Neoproc 40,000,000 IU；
Butylated hydroxyanisole 0.03g；
Aluminium Tristearate Micronized sterile 0.5g；
Surplus is oil for injection.
The preparation method of the neoproc oil preparation suspension injection for animals of the present embodiment, comprises the following steps:
(1) Aluminium Tristearate Micronized sterile accurately weighing recipe quantity adds in oil for injection, and heated and stirred is dissolved；
(2) after Aluminium Tristearate Micronized sterile is completely dissolved, standing lets cool, and slowly topples over, and discards visible foreign；
(3) add after the Butylated hydroxyanisole of recipe quantity being dissolved with oil for injection in the system of step (2), add the neoproc of recipe quantity while stirring, use oil for injection constant volume；
(4) cross homogenizer after the system of step (3) being stirred, obtain neoproc oil preparation suspension injection.
Different batches neoproc oil preparation suspension injection to embodiment 1 preparation, carries out including character, sedimentation volume ratio, the weight quality controling research such as dispersibility and medicament contg.
Character: neoproc oil preparation suspension injection is the suspension solution of fine particle, after standing, fine particle sinks, uniformly faint yellow suspension after jolting.
Sedimentation volume ratio: the method specified according to Chinese veterinary pharmacopoeia, take the neoproc oil preparation suspension injection of different batches in right amount in tool plug graduated cylinder, with after forced oscillation lmin after close plug, the original height Ho (ml) of record suspension, after standing 3h, final height H (ml) of record suspension, by formula F=Ho/H, calculated settlement volume ratio, surveyed F is all higher than 0.91, meets suspension prescription.
Weight dispersibility: the neoproc oil preparation suspension injection of different batches is stood after placing a couple of days, upset rocks suspension for several times gently so that it is redispersion is suspending system uniformly, and result is after rocking several times, all can become uniform suspendible liquid, and without drug precipitation at the bottom of bottle.
Clinical trial:
1, experimental animal
Clinical Mastitis in Dairy Cows in Kunming mastitis average attack rate is 35.9%, the highest by 52.8%, minimum 17.8%, and case fatality rate 5% ~ 8%.The milch cow 96 that mastitis is suffered from Kunming Areas is selected to carry out clinical trial, often group 17-23 cow head.
2, therapeutic effect judges
Clinical recovery: after treatment, the red and swollen heat pain in ill Lac Bovis seu Bubali district disappears, the grumeleuse in Ruzhong, floccule disappear, and lacteous and milk yield recover normal, and spirit and appetite are normal, and drug withdrawal observes more than 7 days without rebound phenomenon；Effective: clinical symptom disappearance, but after discontinuing medication, have rebound phenomenon；Invalid: after treatment, sick cattle symptom does not disappear, even occur that the state of an illness continues to worsen.
3, result is shown in following table
Visible, the injection group of the embodiment of the present invention is after medication, and mammitis of cow cure rate is apparently higher than blank group and sulfa drugs group, the above results shows, the neoproc oil preparation suspension injection of the present invention can significantly improve cure rate, reduces mortality rate, effectively prevents and treats mammitis of cow.
What finally illustrate is, preferred embodiment above is only in order to illustrate technical scheme and unrestricted, although the present invention being described in detail by above preferred embodiment, but skilled artisan would appreciate that, in the form and details it can be made various change, without departing from claims of the present invention limited range.
Claims (3)
1. a neoproc oil preparation suspension injection for animals, it is characterised in that: every 100mL injection is composed of the following components:
Neoproc 20 ~ 40,000,000 IU；
Butylated hydroxyanisole 0.01 ~ 0.04g；
Aluminium Tristearate Micronized sterile 0.2 ~ 0.6g；
Surplus is oil for injection.
2. neoproc oil preparation suspension injection for animals according to claim 1, it is characterised in that: every 100mL injection is composed of the following components:
Neoproc 30,000,000 IU；
Butylated hydroxyanisole 0.02g；
Aluminium Tristearate Micronized sterile 0.4g；
Surplus is oil for injection.
3. the preparation method of the neoproc oil preparation suspension injection for animals described in claim 1 or 2, it is characterised in that: comprise the following steps:
(1) Aluminium Tristearate Micronized sterile accurately weighing recipe quantity adds in oil for injection, and heated and stirred is dissolved；
(2) after Aluminium Tristearate Micronized sterile is completely dissolved, standing lets cool, and slowly topples over, and discards visible foreign；
(3) add after the Butylated hydroxyanisole of recipe quantity being dissolved with oil for injection in the system of step (2), add the neoproc of recipe quantity while stirring, use oil for injection constant volume；
(4) cross homogenizer after the system of step (3) being stirred, obtain neoproc oil preparation suspension injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410793206.4A CN105748406A (en) | 2014-12-20 | 2014-12-20 | A procaine penicillin G oil suspension injection for veterinary use and a preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410793206.4A CN105748406A (en) | 2014-12-20 | 2014-12-20 | A procaine penicillin G oil suspension injection for veterinary use and a preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN105748406A true CN105748406A (en) | 2016-07-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410793206.4A Pending CN105748406A (en) | 2014-12-20 | 2014-12-20 | A procaine penicillin G oil suspension injection for veterinary use and a preparing method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2792329A (en) * | 1950-04-13 | 1957-05-14 | Glaxo Lab Ltd | Aluminum stearate gelled mineral oil containing procaine penicillin with or without streptomycin or dihydrostreptomycin |
| CN101721366A (en) * | 2010-01-13 | 2010-06-09 | 洛阳惠中兽药有限公司 | Components and preparation method of beta-lactam injection |
-
2014
- 2014-12-20 CN CN201410793206.4A patent/CN105748406A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2792329A (en) * | 1950-04-13 | 1957-05-14 | Glaxo Lab Ltd | Aluminum stearate gelled mineral oil containing procaine penicillin with or without streptomycin or dihydrostreptomycin |
| CN101721366A (en) * | 2010-01-13 | 2010-06-09 | 洛阳惠中兽药有限公司 | Components and preparation method of beta-lactam injection |
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Application publication date: 20160713 |
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