CN105745335A - 用于对cMET核酸进行多模态分析的组合物及方法 - Google Patents

用于对cMET核酸进行多模态分析的组合物及方法 Download PDF

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Publication number
CN105745335A
CN105745335A CN201480056221.9A CN201480056221A CN105745335A CN 105745335 A CN105745335 A CN 105745335A CN 201480056221 A CN201480056221 A CN 201480056221A CN 105745335 A CN105745335 A CN 105745335A
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CN
China
Prior art keywords
primer
cmet
gene
amplicon
level
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Pending
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CN201480056221.9A
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English (en)
Chinese (zh)
Inventor
乔克·诺林
希兰·马登纳哈利·迪瓦卡
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Qiagen Mansfield Inc
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Qiagen Mansfield Inc
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Publication of CN105745335A publication Critical patent/CN105745335A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/143—Concentration of primer or probe
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201480056221.9A 2013-08-14 2014-08-07 用于对cMET核酸进行多模态分析的组合物及方法 Pending CN105745335A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361865755P 2013-08-14 2013-08-14
US61/865,755 2013-08-14
PCT/US2014/050076 WO2015023503A2 (en) 2013-08-14 2014-08-07 Compositions and methods for multimodal analysis of cmet nucleic acids

Publications (1)

Publication Number Publication Date
CN105745335A true CN105745335A (zh) 2016-07-06

Family

ID=51358135

Family Applications (1)

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CN201480056221.9A Pending CN105745335A (zh) 2013-08-14 2014-08-07 用于对cMET核酸进行多模态分析的组合物及方法

Country Status (9)

Country Link
US (1) US20160130660A1 (enExample)
EP (1) EP3033434A2 (enExample)
JP (1) JP2016527900A (enExample)
KR (1) KR20160106040A (enExample)
CN (1) CN105745335A (enExample)
BR (1) BR112016003057A2 (enExample)
CA (1) CA2917924A1 (enExample)
SG (1) SG11201600754PA (enExample)
WO (1) WO2015023503A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108893536A (zh) * 2018-07-13 2018-11-27 江苏省人民医院（南京医科大学第附属医院） 一种从人外周血CTC中检测c-MET基因拷贝数变异的方法和试剂盒

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016077687A1 (en) 2014-11-14 2016-05-19 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (als)
JP7336091B2 (ja) * 2016-08-02 2023-08-31 一般社団法人生命科学教育研究所 簡便な遺伝子検査法およびコピー数計測法ならびにその支援技術
WO2018204786A1 (en) 2017-05-05 2018-11-08 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (als)
WO2019079240A1 (en) 2017-10-16 2019-04-25 Voyager Therapeutics, Inc. TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
JP2021533769A (ja) * 2018-08-16 2021-12-09 ライフ テクノロジーズ コーポレーション 核酸の増幅のための試薬、混合物、キット、および方法
KR20210107492A (ko) * 2020-02-24 2021-09-01 (재)록원바이오융합연구재단 복제수 변이 검출용 표준화 유전자의 선별 방법 및 상기 방법에 의해서 선별된 c-Met 복제수 변이 검출용 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2143441A1 (en) * 2008-07-08 2010-01-13 Pierre Fabre Medicament Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer

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JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US7445893B2 (en) 2002-04-12 2008-11-04 Primera Biosystems, Inc. Sampling method for amplification reaction analysis
US20070213292A1 (en) 2005-08-10 2007-09-13 The Rockefeller University Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
CA2705146A1 (en) 2007-11-07 2009-05-14 Primeradx, Inc. Quantification of nucleic acid molecules using multiplex pcr
PA8849001A1 (es) * 2008-11-21 2010-06-28 Lilly Co Eli Anticuerpos de c-met
CN107083444B (zh) * 2008-12-22 2023-03-14 犹他大学研究基金会 单色多重定量pcr
WO2012088337A1 (en) * 2010-12-23 2012-06-28 Prometheus Laboratories Inc. Drug selection for malignant cancer therapy using antibody-based arrays
WO2012119113A2 (en) * 2011-03-02 2012-09-07 Nestec Sa Prediction of drug sensitivity of lung tumors based on molecular and genetic signatures

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2143441A1 (en) * 2008-07-08 2010-01-13 Pierre Fabre Medicament Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SMOLEN GROMOSLAW A ET AL.: "Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752", 《PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES》 *
马天骏等: "DNA拷贝数变异及其研究进展", 《中华临床医师杂志》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108893536A (zh) * 2018-07-13 2018-11-27 江苏省人民医院（南京医科大学第附属医院） 一种从人外周血CTC中检测c-MET基因拷贝数变异的方法和试剂盒
CN108893536B (zh) * 2018-07-13 2022-02-15 江苏省人民医院（南京医科大学第一附属医院） 一种从人外周血CTC中检测c-MET基因拷贝数变异的方法和试剂盒

Also Published As

Publication number Publication date
EP3033434A2 (en) 2016-06-22
US20160130660A1 (en) 2016-05-12
WO2015023503A2 (en) 2015-02-19
SG11201600754PA (en) 2016-02-26
KR20160106040A (ko) 2016-09-09
JP2016527900A (ja) 2016-09-15
CA2917924A1 (en) 2015-02-19
BR112016003057A2 (pt) 2017-11-21
WO2015023503A3 (en) 2015-07-16

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