CN105727021B - A kind of medicament being avoided that treatment vaginitis that intravaginal lactobacillus is killed - Google Patents

A kind of medicament being avoided that treatment vaginitis that intravaginal lactobacillus is killed Download PDF

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CN105727021B
CN105727021B CN201610115509.XA CN201610115509A CN105727021B CN 105727021 B CN105727021 B CN 105727021B CN 201610115509 A CN201610115509 A CN 201610115509A CN 105727021 B CN105727021 B CN 105727021B
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朱有名
潘虹
朱晓蕾
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

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Abstract

The invention discloses a kind of medicaments for being avoided that treatment vaginitis that intravaginal lactobacillus is killed, the medicament pH value is 2.5~6.5, it is mixed by bamboo vinegar or/and wood vinegar with matrix and water, wherein by weight percentage, the content of the bamboo vinegar or wood vinegar is the 2~50% of dose weight, the content of the matrix is the 0.1~35% of dose weight, and the content of the water is the percentage surplus of dose weight.Experiment confirms: medicament of the invention has the killing or inhibiting effect of specificity to harmful pathogenic bacteria, there is no killing or inhibiting effect to probiotic Lactobacillus, overcome the shortcomings that presently relevant drug with antibiotic is main treatment vaginitis, microecology in vaginas environment is maintained well, vagina self-cleaning action possessed by lactobacillus is played, the local immunity for improving vagina is expected to become the optimal drug for the treatment of colpitis, has good potential applicability in clinical practice.

Description

A kind of medicament being avoided that treatment vaginitis that intravaginal lactobacillus is killed
Technical field
The present invention relates to a kind of antimicrobial agent more particularly to a kind for the treatment of vaginas for being avoided that intravaginal lactobacillus and being killed Scorching medicament.
Background technique
Vaginitis is the most common disease of female genital tract infection, is a variety of vaginal mucosa inflammatories caused by different pathogens The general name of disease.Vaginitis has more than ten, including the vacation of trichomonas vaginitis, vulvovaginal according to the difference of its cause of disease and pathogen Silk blastomycosis (original claims vulvovaginal candidiasis), bacterial vaginosis BV, aerobic bacteria property vaginitis, senile vahinitis, baby Child's property vaginitis, viral vaginitis, amebic vaginitis, Drug vaginitis, emphysematous vaginitis, radioactivity vagina Inflammation, anaphylaxis vaginitis, chemically vaginitis etc., one of the most common is first three.
Under normal condition, there are the multiple-microorganisms such as bacterium, fungi, virus, protozoon, main resident bacteria newborn bar for intravaginal Bacterium, corynebacteria, enterococcus faecalis, staphylococcus, streptococcus, bacillus faecalis, mycoplasma and candidiasis etc..A variety of diseases Pathogenic microorganism can cause female genital tract infection.Clinically 50% or more vaginitis is mixed infection.But many vaginas Inflammation is caused by being destroyed due to Tiny ecosystem and the immune function balance of vagina.Lactobacillus accounts for intravaginal and lives away from home carefully under normal circumstances 95% or more of bacterium, lactobacillus can generate lactic acid by glycogen intradermal on glycolysis vaginal mucosa, to maintain the lower pH of intravaginal Value, and pathogenic bacteria are difficult to survive under this acid condition, lactobacillus sticks vagina epithelium with pathogen competition, can produce H2O2, H2O2Itself is also the broad-spectrum antiseptic factor, while lactobacillus and its metabolite can stimulate vaginal mucosa cellular immunity function Can, various cell factors are secreted, the local immunity of vagina is improved, inhibit the survival and reproduction of other bacteriums, to reach yin The self-cleaning action in road.Therefore, when lactobacillus quantity reduces, necessarily lactic acid is caused to reduce, H2O2It reduces, pH value increases, Qi Tazhi Pathogen growth leads to inflammation when serious.
At present to the treatment of vaginitis with sterilize it is anti-inflammatory based on, common treatment method have drug vaginadouche, part put Medicine, oral medication etc., but drug principle active component used is antibiotic, and treatment vaginitis has a serious defect, I.e. while killing or inhibiting pathogenic bacteria, the growth of lactobacillus is killed or is inhibited, the destruction of microecology in vaginas environment is caused, Normal flora imbalance, final result are exactly Relapse rate breaking-out, the more control the more bad.A large amount of report displays, vaginitis and a variety of woman produce Section's disease is related.Because malpractice can cause the complication of pelvic inflammatory disease in gynecology, such as ectopic pregnancy, infertile Deng.In terms of obstetrics, premature rupture of fetal membranes, premature labor, chorioamnionitis, puerperal infection and infection of newborn etc., serious shadow can be caused Ring the physical and mental health of women.Therefore, the treatment for reinforcing vaginitis is very important to the physical and mental health of maintenance women.And A kind of medicament for being avoided that treatment vaginitis that intravaginal lactobacillus is killed is developed and prepares in the treatment to be of great significance.
Summary of the invention
In view of the deficiencies of the prior art, the problem to be solved in the present invention is to provide one kind to be avoided that intravaginal lactobacillus is killed The medicament for the treatment vaginitis gone out.
The medicament of the present invention for being avoided that treatment vaginitis that intravaginal lactobacillus is killed, it is characterised in that: described Medicament pH value is 2.5~6.5, is mixed by bamboo vinegar or/and wood vinegar with matrix and water, wherein by weight percentage, The content of the bamboo vinegar or/and wood vinegar is the 2~50% of dose weight, and the content of the matrix is the 0.1 of dose weight ~35%, the content of the water is the percentage surplus of dose weight；Bamboo vinegar described in each component is commercial product or utilization Acidic liquid is made through destructive distillation in bamboo, and using precipitating, absorption or way of distillation purification are obtained；The wood vinegar be commercial product or Through destructive distillation acidic liquid to be made using weedtree, branch, bark, shell, fruit stone, stalk, rice husk, using precipitating, absorption or Way of distillation purification obtains；The matrix is glycerin gelatine, glycerinum amyli, cellulose derivative, sodium alginate, polysorbate, shell Glycan, chitosan derivatives, carbomer, poloxamer, glycerol, polyethylene glycol, disodium ethylene diamine tetraacetate, propylene glycol, three second One of hydramine, tween or its any weight ratio mix several.
The above-mentioned medicament preferred embodiment for being avoided that treatment vaginitis that intravaginal lactobacillus is killed is: the medicine Agent pH value is 2.6~5.5, is mixed by bamboo vinegar or/and wood vinegar with matrix and water, wherein by weight percentage, institute The content for stating bamboo vinegar or/and wood vinegar is the 5~40% of dose weight, the content of the matrix be dose weight 0.1~ 25%, the content of the water is the percentage surplus of dose weight；Bamboo vinegar described in each component is commercial product or utilizes bamboo Acidic liquid is made through destructive distillation in son, and using precipitating, absorption or way of distillation purification are obtained；The wood vinegar be commercial product or Acidic liquid is made through destructive distillation using weedtree, branch, bark, shell, fruit stone, stalk, rice husk, using precipitating, absorption or steaming Method purification is evaporated to obtain；The matrix is glycerin gelatine, sodium alginate, chitosan, carbomer, poloxamer, glycerol, ethylenediamine tetraacetic One of acetic acid disodium, propylene glycol, triethanolamine, tween or its any weight ratio mix several.
The above-mentioned medicament further preferred embodiment for being avoided that treatment vaginitis that intravaginal lactobacillus is killed is: The medicament pH value is 2.8~5.0, is mixed by bamboo vinegar or/and wood vinegar with matrix and water, wherein with weight percent The content of meter, the bamboo vinegar or/and wood vinegar is the 8~35% of dose weight, and the content of the matrix is dose weight 0.5~8%, the content of the water is the percentage surplus of dose weight；Bamboo vinegar described in each component is using bamboo through destructive distillation Acidic liquid is made, using precipitating, absorption or way of distillation purification are obtained；The wood vinegar is passed through using weedtree, shell, stalk Acidic liquid is made in destructive distillation, and using precipitating, absorption or way of distillation purification are obtained；The matrix is glycerin gelatine, chitosan, card What one of wave nurse, glycerol, tween, propylene glycol, triethanolamine, disodium ethylene diamine tetraacetate or its any weight ratio mixed It is several.
The embodiment of the above-mentioned medicament for being avoided that treatment vaginitis that intravaginal lactobacillus is killed still further preferably Be: the medicament pH value is 2.8~4.8, is mixed by bamboo vinegar or/and wood vinegar with matrix and water, wherein with weight hundred Divide than counting, the content of the bamboo vinegar or/and wood vinegar is the 8~30% of dose weight, and the content of the matrix is medicament weight The 0.5~6.5% of amount, the content of the water are the percentage surplus of dose weight；Bamboo vinegar described in each component is to utilize bamboo Acidic liquid is made through destructive distillation, using precipitating, absorption or way of distillation purification are obtained；The wood vinegar be using weedtree, shell, Acidic liquid is made through destructive distillation in stalk, and using precipitating, absorption or way of distillation purification are obtained；The matrix is glycerin gelatine, shell One of glycan, carbomer, glycerol, tween or its any weight ratio mix several.
The above-mentioned most preferred embodiment citing of medicament for being avoided that treatment vaginitis that intravaginal lactobacillus is killed: institute Stating medicament pH value is 3.5~4.5, is mixed by wood vinegar and matrix and water, wherein by weight percentage, the wood vinegar Content be the 10~20% of dose weight, the content of the matrix is the 2~3.5% of dose weight, and the content of the water is The percentage surplus of dose weight；Wood vinegar described in each component is that acidic liquid is made through destructive distillation using weedtree, shell, stalk, Using precipitating, absorption or way of distillation purification are obtained；The matrix is the liquid that the weight ratio such as carbomer and glycerol mix.
The above-mentioned most preferred embodiment of medicament for being avoided that treatment vaginitis that intravaginal lactobacillus is killed is illustrated again: The medicament pH value is 2.8~3.5, by etc. weight ratios mixing bamboo vinegar and wood vinegar be mixed with matrix and water, wherein By weight percentage, the total content of the bamboo vinegar and wood vinegar is the 8~15% of dose weight, and the content of the matrix is The 0.5~5% of dose weight, the content of the water are the percentage surplus of dose weight；Bamboo vinegar described in each component is to utilize Acidic liquid is made through destructive distillation in bamboo, and using precipitating, absorption or way of distillation purification are obtained；The wood vinegar be using weedtree, Acidic liquid is made through destructive distillation in shell, stalk, and using precipitating, absorption or way of distillation purification are obtained；The matrix is chitosan.
The invention discloses a kind of medicaments for being avoided that treatment vaginitis that intravaginal lactobacillus is killed.Experiment confirms: The medicament for the treatment of vaginitis provided by the invention is to harmful pathogenic bacterias such as Gartner bacterium, Candida albicans, staphylococcus aureuses There is the killing or inhibiting effect of specificity, there is no killing or inhibiting effect to probiotic Lactobacillus, overcomes treatment vagina at present The shortcomings that scorching related drugs cause microecology in vaginas flora to destroy using antibiotic, maintains microecology in vaginas ring well Border has played vagina self-cleaning action possessed by lactobacillus, improves the local immunity of vagina, is expected to become treatment vaginitis The optimal drug of disease has good potential applicability in clinical practice.
Specific embodiment
Heretofore described bamboo vinegar is commercial product (such as Shijiazhuang Hua Zhuo Activated Carbon Production Co., Ltd product, ground Location: Zhengding County new city spreads town airport industrial park；Or Shaanxi Yixin Biological Energy Science and Technology Development Co., Ltd.'s product, address: in State, Xianyang, the Xi'an City, Shanxi Province town the Yangling Area Wu Quan village Shang Wan.) or using bamboo acidic liquid is made through destructive distillation, then By precipitating, absorption or way of distillation purification are obtained.
Heretofore described wood vinegar is commercial product (such as Suichang County Dragon Lord Gu Tan industry Co., Ltd product, address: Zhejiang The Suichang County Jiang Sheng Mudanjiang Road 185；Or Zhejiang Yiwu Bao Tai household items Co., Ltd product, the Zhejiang road Yiwu City Cheng Dian No. 38-1 3 buildings 4 buildings.) or using weedtree, branch, bark, shell, fruit stone, stalk, rice husk acidic liquid is made through destructive distillation, then By precipitating, absorption or way of distillation purification are obtained.
Above-mentioned bamboo vinegar or/and wood vinegar those skilled in the art can prepare according to a conventional method.
Embodiment 1: it is a kind of be avoided that intravaginal lactobacillus kill treatment vaginitis medicament and its preparation
Reagent combination: 260 grams of wood vinegar, carbomer 200, Tween 80 gram, propylene glycol are 10 grams, disodium ethylene diamine tetraacetate 2g grams, triethanolamine be 58 grams, 390 grams of water.
Medicament preparation: take carbomer cross 100 mesh or more sieve it is spare；The water of design flow is taken to be heated to 50~65 DEG C, heat preservation is stirred It mixes down, first disodium ethylene diamine tetraacetate is dissolved in the water, then carbomer is added thereto, its swelling is made to become uniform glue Body；The water of triethanolamine surplus is diluted, under insulated and stirred, is slowly added into above-mentioned colloid, then tween, propylene glycol are stirred Under be added thereto, continue insulated and stirred make it completely dissolved, be uniformly mixed, and make pH value 4.8, dispense to obtain the final product.
Embodiment 2: it is a kind of be avoided that intravaginal lactobacillus kill treatment vaginitis medicament and its preparation
Reagent combination: 10 grams of bamboo vinegar, 2 grams of glycerin gelatine, 0.01 gram of tween, 88 grams of water.
Medicament preparation: bamboo vinegar is added in water, is adjusted pH value to 4.5, is heated to 60~70 DEG C, it is added in glycerin gelatine In, tween is added after its dissolution, stirs evenly, dispenses.
Embodiment 3: it is a kind of be avoided that intravaginal lactobacillus kill treatment vaginitis medicament and its preparation
Reagent combination: 10 grams of wood vinegar, 1 gram of carbomer, 1 gram of glycerol, 88 grams of water.
Medicament preparation: wood vinegar is added in water, is adjusted pH value to 3.5, is heated to 60~70 DEG C, carbomer will be added to enter it In, glycerol is added after its dissolution, stirs evenly, dispenses.
Embodiment 4: it is a kind of be avoided that intravaginal lactobacillus kill treatment vaginitis medicament and its preparation
Reagent combination: 5 grams of wood vinegar, 3 grams of bamboo vinegar, 5 grams of chitosan, 87 grams of water.
Medicament preparation: wood vinegar, bamboo vinegar are added in water, are adjusted pH value to 3.0,60~70 DEG C are heated to, by chitosan It is added thereto, stirs evenly, dispense after its dissolution.
Embodiment 5: it is a kind of be avoided that intravaginal lactobacillus kill treatment vaginitis medicament and its preparation
Reagent combination: 5 grams of wood vinegar, 5 grams of bamboo vinegar, 8 grams of chitosan, 82 grams of water.
Medicament preparation: wood vinegar, bamboo vinegar are added in water, are adjusted pH value to 2.8,60~70 DEG C are heated to, by chitosan It is added thereto, stirs evenly, dispense after its dissolution.
Embodiment 6: the medicament bacteriostatic test for the treatment of vaginitis of the invention
Bacteriostatic test
Strain: Candida albicans, Gartner bacterium, Bacillus acidi lactici, staphylococcus aureus, Escherichia coli.
Culture medium: conventional anaerobic culture medium, Bacillus acidi lactici culture medium, ordinary culture medium.
Sample: medicament sample, the metronidazole positive control for the treatment of vaginitis prepared by embodiment 3.
Method: it is operated by plate bacteriostatic test method.
It is Candida albicans, staphylococcus aureus, big with anaerobic culture medium to Gartner bacterium, Bacillus acidi lactici Anaerobic culturel Enterobacteria is cultivated according to a conventional method.
Bacteriostatic test result statistics see the table below:
Experiment confirms: the medicament for the treatment of vaginitis provided by the invention is to Gartner bacterium, Candida albicans, golden yellow grape The harmful pathogenic bacterias such as coccus, Escherichia coli have the killing or inhibiting effect of specificity, and probiotic Lactobacillus is not killed or pressed down Production is used.

Claims (2)

1. a kind of medicament for being avoided that treatment vaginitis that intravaginal lactobacillus is killed, mixes system with matrix and water by wood vinegar At, wherein the wood vinegar is that acidic liquid is made through destructive distillation using weedtree, shell, stalk, and using precipitating, absorption or distillation Method purification obtains；
It is characterized by:
The pH value of the medicament is 3.5~4.5, and by weight percentage, the content of wood vinegar is the 10 of dose weight to component ~20%, the content of matrix is the 2~3.5% of dose weight, and the content of water is the percentage surplus of dose weight；The wherein base Matter is the liquid that the weight ratio such as carbomer and glycerol mix.
2. a kind of medicament for being avoided that treatment vaginitis that intravaginal lactobacillus is killed, by etc. weight ratios mixing bamboo vinegar and Wood vinegar is mixed with matrix and water, wherein the bamboo vinegar is that acidic liquid is made through destructive distillation using bamboo, using heavy It forms sediment, absorption or way of distillation purification obtain；The wood vinegar is acidic liquid to be made through destructive distillation using weedtree, shell, stalk, then pass through Precipitating is crossed, absorption or way of distillation purification obtain；
It is characterized by:
The pH value of the medicament is 2.8~3.5, component by weight percentage, the bamboo vinegar of the weight ratios such as described mixing and The total content of wood vinegar is the 8~15% of dose weight, and the content of the matrix is the 0.5~5% of dose weight, the water Content is the percentage surplus of dose weight；Wherein the matrix is chitosan.
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CN108785680A (en) * 2018-07-10 2018-11-13 杨先锋 It is a kind of to be applied using the gel of biomass through pyrolysis liquid preparation and its in preparing gynaecology external-use drug

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1101276A (en) * 1994-04-13 1995-04-12 吴晓景 External-use medicine composition for vaginitis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1101276A (en) * 1994-04-13 1995-04-12 吴晓景 External-use medicine composition for vaginitis

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