CN105726167A - Involved artificial heart valve prosthesis - Google Patents

Involved artificial heart valve prosthesis Download PDF

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Publication number
CN105726167A
CN105726167A CN201610074784.1A CN201610074784A CN105726167A CN 105726167 A CN105726167 A CN 105726167A CN 201610074784 A CN201610074784 A CN 201610074784A CN 105726167 A CN105726167 A CN 105726167A
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CN
China
Prior art keywords
submounts
support
insertion type
type artificial
sub
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Pending
Application number
CN201610074784.1A
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Chinese (zh)
Inventor
虞奇峰
秦涛
杨剑
王海山
梁玉晨
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Shanghai Niu Mai Medical Science And Technology Co Ltd
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Shanghai Niu Mai Medical Science And Technology Co Ltd
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Application filed by Shanghai Niu Mai Medical Science And Technology Co Ltd filed Critical Shanghai Niu Mai Medical Science And Technology Co Ltd
Priority to CN201610074784.1A priority Critical patent/CN105726167A/en
Publication of CN105726167A publication Critical patent/CN105726167A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418Scaffolds therefor, e.g. support stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves

Abstract

The invention provides an involved artificial heart valve prosthesis.A support of the involved artificial heart valve prosthesis sequentially comprises a first sub-support, a second sub-support and a third sub-support connected in sequence.The first sub-support is a net pipe in a cone frustum shape, the second sub-support is a cylindrical net pipe, and the third sub-support is a trumpet-shaped net pipe.The maximum pipe diameter of the first sub-support is the same as the pipe diameter of the second sub-support.The minimum pipe diameter of the third sub-support is the same as that pipe diameter of the second sub-support.Due to the fact that the first sub-support is designed as the net pipe in the cone frustum shape, compared with an existing support designed as a cylindrical net pipe, the length of the support is reduced through the structure of the first sub-support, and harm caused by the fact that a too long part of the support punctures into the surrounding heart tissue to the heart is avoided.In addition, due to the fact that barbs with a locating function are arranged on the first sub-support, it is avoided that the involved artificial heart valve prosthesis shifts after being released; meanwhile, the structure is matched with the surrounding tissue, a blocking structure can be conveniently formed through membranae tectoria, perivalvular leakage can be avoided, and the success rate of an operation is increased.

Description

A kind of insertion type artificial cardiac valve
Technical field
The present invention relates to technical field of medical instruments, particularly to a kind of insertion type artificial cardiac valve.
Background technology
Heart is the very important organ of human body, power is provided for blood circulation of human body, heart is divided into left and right two parts, every part comprises a ventricle and atrium, separated by interventricular septum and interatrial septum between ventricle and ventricle and between atrium and atrium, there is the valve preventing blood reflux between room, room, tremulous pulse.
Mitral position is between left atrium and left ventricle, such as same one-way cock, it is ensured that blood is flowed to left ventricle direction by left atrium and passes through certain flow.Mitral complex is one group of function and dissects baroque device, it is generally recognized that include annulus, leaflet, chordae tendineae and papillary muscles.Mitral function depends on the integrity of its physiological structure.During normal MC, two leaflets be in approximately the same plane and involutory closely, it is possible to stop the backflow of ventricular blood flow completely.Reach such effect, it is desirable to annulus of mitral valve size to fit, leaflet structural integrity, papillary muscle retracts tractive chordae tendineae play closedown strength that the supporting role of leaflet, left ventricle muscle contraction are produced suitably, ventricular morphology and function normal.In these factors, any one occurs extremely can result in mitral incompetence (MR).
The cause of disease is the most common for valvular heart disease, and women is more common.Other commonly encountered diseases because including mitral valve prolapse, papillary muscles nonfunction that Bicuspid valve degeneration, mitral annular calcification, myocardial ischemia cause, left ventricular enlargement cause functional mitral incompetence, infective endocarditis, congenital malformation etc..Surgery prosthetic valve replacement operation wound is big, and the recovery time of patient is long, therefore to gerontal patient often because of advanced age, body constitution is weak, pathological changes is heavy or merges Other diseases and avoids performing the operation.
In recent years, along with the progress of interventional therapeutic technique, carry insertion type artificial cardiac valve displacement or prothesis are developed rapidly and are applied to clinic through conduit, achieve comparatively satisfied effect.Get involved operation by Wicresoft and insertion type artificial cardiac valve is implanted in the original position Bicuspid valve of heart, carry out related work with the natural valve of displacement or reparation infringement.Described insertion type artificial cardiac valve mainly includes support, and it is arranged at the leaflet of internal stent, operation process is without opening breast, thus wound is little, post-operative recovery is fast, its life can not be extended for those current conventional therapy means or alleviate the valvular stenosis patient of its misery, it is provided that a kind of new solution.
But owing to interventional therapeutic technique time of occurrence is shorter, during application, also face more problem.Such as some insertion type artificial cardiac valves are in use owing to support force is not enough, it is easy to fracture;Support is inadequate with the physiological structure degree of agreement of natural valve, it is easy to perivalvular leakage occurs;Supporting structure easily oppresses heart efferent tract;Supporting structure is long excessive, injures heart;Development point design is unreasonable, affects operation technique.For the problem existing for existing insertion type artificial cardiac valve, the method that those skilled in the art always search for solving.
Summary of the invention
It is an object of the invention to provide a kind of insertion type artificial cardiac valve, to solve existing insertion type artificial cardiac valve to meet work requirements, support is inadequate with the physiological structure degree of agreement of natural valve, it is easy to be subjected to displacement and perivalvular leakage;Supporting structure easily oppresses heart efferent tract;Supporting structure is long excessive, injures heart;Development point design is unreasonable, the problem affecting operation technique.
For solving above-mentioned technical problem, the present invention provides a kind of insertion type artificial cardiac valve, and described insertion type artificial cardiac valve includes:
Support, it is arranged at the leaflet inside described support and is arranged at the overlay film on described support body wall;Wherein,
Described support includes the first submounts, the second submounts and the 3rd submounts that are sequentially connected with, and described first submounts is circular cone shape webmaster, and described second submounts is cylindric webmaster, and described 3rd submounts is horn-like webmaster;The maximum caliber of described first submounts is identical with the caliber of described second submounts, the minimum pipe of described 3rd submounts is identical with the caliber of described second submounts, the body wall of described first submounts and/or described second submounts is provided with agnail, the free end of described agnail tilts along the direction of the free end deviating from described first submounts, and the overlay film on described 3rd submounts and/or on described 3rd submounts is provided with development point.
Optionally, in described insertion type artificial cardiac valve, the body wall of relatively described second submounts of body wall of described first submounts tilts 10 degree~60 degree.
Optionally, in described insertion type artificial cardiac valve, the angle between the body wall of the free end of described agnail and the first submounts or described second submounts is 20 degree~80 degree, and the length of described agnail is 3mm~10mm.
Optionally, in described insertion type artificial cardiac valve, also including conveying connection member, described conveying connection member is arranged at the free end of described first submounts.
Optionally, in described insertion type artificial cardiac valve, the quantity of described conveying connection member is at least 3.
Optionally, in described insertion type artificial cardiac valve, the quantity of described development point is 2.
Optionally, in described insertion type artificial cardiac valve, the quantity of described leaflet is at least two panels.
Optionally, in described insertion type artificial cardiac valve, described leaflet is biological tissue, the valve of Polymer materialspreparation or tissue engineered heart valve.
Optionally, in described insertion type artificial cardiac valve, described first submounts or be provided with leaflet sewing hole on described second submounts, by described leaflet sewing hole, described leaflet is sutured on described support.
Optionally, in described insertion type artificial cardiac valve, the material of described support is Nitinol, and the material of described overlay film is one or more in PET, e-PTFE, pericardium material.
In insertion type artificial cardiac valve provided by the present invention, described insertion type artificial cardiac valve includes support, is arranged at the leaflet inside support and is arranged at the overlay film on support body wall, support includes the first submounts, the second submounts and the 3rd submounts that are sequentially connected with, first submounts is circular cone shape webmaster, second submounts is cylindric webmaster, and the 3rd submounts is horn-like webmaster;The maximum caliber of the first submounts and the caliber of the second submounts are identical, and the minimum pipe of the 3rd submounts is identical with the caliber of the second submounts.By the first submounts is designed as circular cone shape webmaster, and first submounts maximum caliber and the caliber of the second submounts identical, compared with being designed as cylindric webmaster with existing insertion type artificial cardiac valve medium-height trestle, in the present invention, the structure of the first submounts shortens the length of support, avoid and thrust the injury that heart is caused by surrounding heart tissue owing to support is long, improve the success rate of operation;On the other hand, owing to supporting structure matches with the physiological structure of natural valve, the body wall of described first submounts or described second submounts is provided with agnail, agnail can thrust the tissue of valve periphery after cardiac valve is implanted to ad-hoc location, play positioning action so that after insertion type artificial cardiac valve release, be not susceptible to displacement and perivalvular leakage;On the other hand, relatively reasonable based on a present invention position arranged of developing, meet the demand of operation.
Accompanying drawing explanation
Fig. 1 is the structural representation of the original position PM that insertion type artificial cardiac valve is implanted to heart in one embodiment of the invention;
Fig. 2 is the front view of the support of insertion type artificial cardiac valve in one embodiment of the invention;
Fig. 2 a is the top view of Fig. 2;
Fig. 3 is the front view after the support overlay film of insertion type artificial cardiac valve in one embodiment of the invention;
Fig. 3 a is the top view after the inside of the support of Fig. 3 is sewed with leaflet.
In figure: support 1;Leaflet 2;Overlay film 3;First submounts 10;Second submounts 11;3rd submounts 12;Agnail 4;Conveying connection member 5;Development point 6;Leaflet sewing hole 110.
Detailed description of the invention
The insertion type artificial cardiac valve present invention proposed below in conjunction with the drawings and specific embodiments is described in further detail.According to the following describes and claims, advantages and features of the invention will be apparent from.It should be noted that, accompanying drawing all adopts the form simplified very much and all uses non-ratio accurately, only in order to convenience, the purpose aiding in illustrating the embodiment of the present invention lucidly.
Before illustrating the present invention, in this cardinal principle that present invention is first described and thought.For Minimally Interventional Therapy, the support of insertion type artificial cardiac valve of the present invention can radially stretch, when installing conveying, it is easy to tighten up support in the conveyer device loading finite volume, when strutting rapidly again after release from conveyer device, it is easy to fit tightly with destination organization, forms sufficient channel of blood flow;The structure of described 3rd submounts matches (especially matching) with the native physiological structure of Bicuspid valve surrounding tissue with the physiological structure of natural valve, there is certain self-locating function, it is easy to be quickly and accurately positioned release, and release after-poppet fits tightly channel of blood flow, it is not susceptible to displacement, simultaneously this structure coordinate with surrounding tissue be easy to overlay film formed plugging structure, be conducive to avoiding perivalvular leakage;Described agnail can thrust the tissue of valve periphery after cardiac valve is implanted to ad-hoc location, play positioning action, it is not susceptible to displacement and perivalvular leakage after making cardiac valve release, as the blood inlet of blood behind described 3rd submounts implantation position of valve, the first submounts is as the blood outlet of blood.Owing to the diameter of described 3rd submounts structural portion is more than the diameter of described second submounts, when because of diastole, the 3rd submounts portion can be played barrier effect and prevent the centripetal indoor landing of valve by natural plate ring tissue, and when the heart contracts, owing to the effect of agnail can stop again valve to move, therefore the support of this structure, it is shifted in blood stream pressure with under washing away after can more efficiently preventing from valve release, longer service life after valve release, the injury of surrounding tissue is little.
Fig. 1 is the structural representation that the insertion type artificial cardiac valve of the present invention is implanted to the original position PM of heart.Fig. 2 is the front view of the support of insertion type artificial cardiac valve of the present invention.Fig. 3 is the front view after the support overlay film of insertion type artificial cardiac valve in one embodiment of the invention.Fig. 3 a is the top view after the inside of the support of Fig. 3 is sewed with leaflet.As shown in Fig. 2, Fig. 3-Fig. 3 a, the insertion type artificial cardiac valve of the present invention includes: support 1, is arranged at the leaflet 2 inside described support 1 and is arranged at the overlay film 3 on described support 1 body wall;Wherein, described support 1 includes the first submounts the 10, second submounts 11 and the 3rd submounts 12 being sequentially connected with, and described first submounts 10 is circular cone shape webmaster, and described second submounts 11 is cylindric webmaster, and described 3rd submounts 12 is in horn-like webmaster;The maximum caliber of described first submounts 10 is identical with the caliber of described second submounts 11, and the minimum pipe of described 3rd submounts 12 is identical with the caliber of described second submounts 11.
Refer to Fig. 2 and Fig. 2 a, described first submounts the 10, second submounts 11 and the 3rd submounts 12 three are coaxial, and three is distinctive in that shape is different.Actual when preparing support, it is adopt same original webmaster, it is divided into three sections to carry out moulding technology original webmaster, second submounts 11 is identical with the caliber of original webmaster, namely without deformation process, the first submounts 10 is the edge radial contraction along original webmaster of the one end by original webmaster, presents the shape being numbered 10 parts in Fig. 2, the angle, θ that the body wall of relatively described second submounts 11 of body wall of the first submounts 10 described here tilts is 10 degree~60 degree, it is preferred to 30 degree.
Refer to Fig. 2 and Fig. 3, the body wall of described first submounts 10 or described second submounts 11 is provided with agnail 4, the free end of described agnail 4 tilts along the direction of the free end deviating from described first submounts 10, angle between the body wall of agnail 4 and the first submounts 10 or described second submounts 11 is 20 degree~80 degree, it is preferred that 60 degree.The length of described agnail is 3mm~10mm.During application, agnail 4 thrusts the tissue of valve periphery, plays the effect of location insertion type artificial cardiac valve.Here, the quantity of agnail 4 is multiple, and multiple described agnails 4 are evenly distributed on the periphery of the first submounts 10 or the second submounts 11.
Concrete, insertion type artificial cardiac valve in the present embodiment can radially stretch, when installing conveying insertion type artificial cardiac valve, for the ease of fitting tightly with destination organization, to form the channel of blood flow of abundance, the structural design that the structure of above-mentioned second submounts and described 3rd submounts matches is that the physiological structure with natural valve matches (especially matching) with the native physiological structure of mitral surrounding tissue thus making it have certain self-locating function by the present invention, it is easy to be quickly and accurately positioned release, and release after-poppet fits tightly channel of blood flow, it is not susceptible to displacement, simultaneously this structure coordinate with surrounding tissue be easy to overlay film formed plugging structure, be conducive to avoiding perivalvular leakage.
nullDuring practical application,Insertion type artificial cardiac valve is to be placed in conveyer device implantation within a patient,When arriving target location,Release insertion type artificial cardiac valve,Now the support of insertion type artificial cardiac valve can be strutted rapidly by compressive state,Known as shown in Figure 1,After insertion type artificial cardiac valve release, the first submounts is positioned at ventricle,3rd submounts is arranged in atrium,Described 3rd submounts is as the blood inlet of blood,First submounts is as the blood outlet of blood,Owing to the caliber of the 3rd submounts is more than the caliber of described second submounts,When because of diastole, the 3rd submounts can be played barrier effect and prevent the centripetal indoor landing of insertion type artificial cardiac valve by natural plate ring tissue,And when the heart contracts,Owing to the effect of agnail can stop again insertion type artificial cardiac valve to shift,Therefore based on the supporting structure of the present invention,It is shifted in blood stream pressure with under washing away after can more efficiently preventing from insertion type artificial cardiac valve release,Extend the service life after insertion type artificial cardiac valve release,Reduce its injury to surrounding tissue.
As shown in Figure 3 a, would know that the distributing position of leaflet 2 and shape thereof, in the present embodiment, the quantity of leaflet 2 is at least two panels.Described leaflet is biological tissue's (such as Cor Sus domestica bag, bovine pericardium, Cor Sus domestica lobe, Cor Bovis seu Bubali lobe etc.), the valve of Polymer materialspreparation or tissue engineered heart valve.Wherein, described leaflet includes rectangular portion and the curved portions being connected with described rectangular portion, adopts the leaflet of this shape to be easy to coordinate stitching, and the hemodynamic effect of gained valve is good.Wherein, as in figure 2 it is shown, in order to leaflet be arranged in described support, the present invention is provided with leaflet sewing hole 110 on described first submounts or described second submounts, described leaflet is sutured on described support by described leaflet sewing hole 110.
Further, refer to Fig. 2, Fig. 2 a and Fig. 3, be combined with conveyer device in delivery phase for the ease of insertion type artificial cardiac valve, the free end at described first submounts is provided with conveying connection member 5, and the quantity of described conveying connection member 5 is at least 2.
Refer to Fig. 2 and Fig. 3 a, in order to meet location and the position of observation insertion type artificial cardiac valve, being provided with development point 6 on overlay film on described 3rd submounts and/or on described 3rd submounts, the quantity of described development point 6 is 3, and three development points 6 are uniformly arranged along the circumference of support.Concrete, if development point 6 is arranged on the 3rd submounts, then the outer wall on described 3rd submounts needs to be provided with development hole, described development hole is filled with developing media;If development point 6 is arranged in overlay film, then in the covering material needing to arrange the position of development point 6, add developing media.Above-mentioned developing media is one or more in platinumiridio (Pt/Ir), platinum (Pt), tantalum metal (Ta).
It is also preferred that the left the material of described support is Nitinol, the material of described overlay film is one or more in PET, e-PTFE, pericardium material.
Preferably, the mesh shape of the cylindric webmaster of described second submounts is designed as rhombus, to improve insertion type artificial cardiac valve in use support force, it is to avoid the problem occurring causing the fracture of support due to support force deficiency.
To sum up, in insertion type artificial cardiac valve provided by the present invention, described insertion type artificial cardiac valve includes support, is arranged at the leaflet inside support and is arranged at the overlay film on support body wall, support includes the first submounts, the second submounts and the 3rd submounts that are sequentially connected with, first submounts is circular cone shape webmaster, second submounts is cylindric webmaster, and the 3rd submounts is horn-like webmaster;The maximum caliber of the first submounts and the caliber of the second submounts are identical, and the minimum pipe of the 3rd submounts is identical with the caliber of the second submounts.By the first submounts is designed as circular cone shape webmaster, and first submounts maximum caliber and the caliber of the second submounts identical, compared with being designed as cylindric webmaster with existing insertion type artificial cardiac valve medium-height trestle, in the present invention, the structure of the first submounts shortens the length of support, avoid and thrust the injury that heart is caused by surrounding heart tissue owing to support is long, improve the success rate of operation;On the other hand, owing to supporting structure matches with the physiological structure of natural valve, the body wall of described first submounts and/or described second submounts is provided with agnail, agnail can thrust the tissue of valve periphery after cardiac valve is implanted to ad-hoc location, play positioning action, being not susceptible to displacement after making insertion type artificial cardiac valve release, simultaneously valve coordinates with surrounding tissue and is easy to overlay film formation plugging structure, is conducive to avoiding perivalvular leakage;On the other hand, relatively reasonable based on a present invention position arranged of developing, meet the demand of operation.
Foregoing description is only the description to present pre-ferred embodiments, not any restriction to the scope of the invention, any change that the those of ordinary skill in field of the present invention does according to the disclosure above content, modification, belongs to the protection domain of claims.

Claims (10)

1. an insertion type artificial cardiac valve, it is characterised in that including: support, be arranged at the leaflet inside described support and be arranged at the overlay film on described support body wall;Wherein,
Described support includes the first submounts, the second submounts and the 3rd submounts that are sequentially connected with, and described first submounts is circular cone shape webmaster, and described second submounts is cylindric webmaster, and described 3rd submounts is horn-like webmaster;The maximum caliber of described first submounts is identical with the caliber of described second submounts, the minimum pipe of described 3rd submounts is identical with the caliber of described second submounts, the body wall of described first submounts or described second submounts is provided with agnail, the free end of described agnail tilts along the direction of the free end deviating from described first submounts, and the overlay film on described 3rd submounts and/or on described 3rd submounts is provided with development point.
2. insertion type artificial cardiac valve as claimed in claim 1, it is characterised in that the body wall of relatively described second submounts of body wall of described first submounts tilts 10 degree~60 degree.
3. insertion type artificial cardiac valve as claimed in claim 1, it is characterised in that the angle between the body wall of the free end of described agnail and the first submounts or described second submounts is 20 degree~80 degree, and the length of described agnail is 3mm~10mm.
4. insertion type artificial cardiac valve as claimed in claim 1, it is characterised in that also including conveying connection member, described conveying connection member is arranged at the free end of described first submounts.
5. insertion type artificial cardiac valve as claimed in claim 4, it is characterised in that the quantity of described conveying connection member is at least 2.
6. insertion type artificial cardiac valve as claimed in claim 5, it is characterised in that the quantity of described development point is 3.
7. insertion type artificial cardiac valve as claimed in claim 1, it is characterised in that the quantity of described leaflet is at least two panels.
8. insertion type artificial cardiac valve as claimed in claim 7, it is characterised in that described leaflet is biological tissue, the valve of Polymer materialspreparation or tissue engineered heart valve.
9. the insertion type artificial cardiac valve as according to any one of claim 1-8, it is characterised in that described first submounts or be provided with leaflet sewing hole on described second submounts, is sutured in described leaflet on described support by described leaflet sewing hole.
10. the insertion type artificial cardiac valve as according to any one of claim 1-8, it is characterised in that the material of described support is Nitinol, the material of described overlay film is one or more in PET, e-PTFE, pericardium material.
CN201610074784.1A 2016-02-02 2016-02-02 Involved artificial heart valve prosthesis Pending CN105726167A (en)

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Cited By (12)

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CN106175987A (en) * 2016-08-31 2016-12-07 上海纽脉医疗科技有限公司 Cardiac valve prosthesis
CN107088112A (en) * 2017-05-18 2017-08-25 金仕生物科技(常熟)有限公司 One kind is through conduit aortic valve
WO2018077146A1 (en) * 2016-10-24 2018-05-03 宁波健世生物科技有限公司 Asymmetrical heart valve prosthesis
WO2018077143A1 (en) * 2016-10-24 2018-05-03 宁波健世生物科技有限公司 Heart valve prosthesis
WO2018077145A1 (en) * 2016-10-24 2018-05-03 宁波健世生物科技有限公司 Adaptive heart valve prosthesis
CN108542554A (en) * 2018-03-05 2018-09-18 沛嘉医疗科技(苏州)有限公司 Through catheter heart valves holder
CN109549754A (en) * 2017-09-25 2019-04-02 先健科技(深圳)有限公司 Heart valve
CN109549753A (en) * 2017-09-25 2019-04-02 先健科技(深圳)有限公司 Heart valve
CN110882026A (en) * 2018-09-11 2020-03-17 上海捍宇医疗科技有限公司 Apex of heart closure ware
CN113057765A (en) * 2021-03-26 2021-07-02 上海申淇医疗科技股份有限公司 Artificial heart valve
US20220257374A1 (en) * 2021-02-18 2022-08-18 P+F Products + Features Gmbh Mitral Stent
WO2023279491A1 (en) 2021-07-07 2023-01-12 上海臻亿医疗科技有限公司 Valve prosthesis

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