CN105722860A - 白介素-2融合蛋白及其应用 - Google Patents
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Classifications
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- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1761—Apoptosis related proteins, e.g. Apoptotic protease-activating factor-1 (APAF-1), Bax, Bax-inhibitory protein(s)(BI; bax-I), Myeloid cell leukemia associated protein (MCL-1), Inhibitor of apoptosis [IAP] or Bcl-2
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
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- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
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- Wood Science & Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Marine Sciences & Fisheries (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
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| US201361881931P | 2013-09-24 | 2013-09-24 | |
| US61/881,931 | 2013-09-24 | ||
| PCT/CA2014/050917 WO2015042707A1 (fr) | 2013-09-24 | 2014-09-24 | Protéines hybrides de l'interleukine-2 et leurs utilisations |
Publications (1)
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| CN105722860A true CN105722860A (zh) | 2016-06-29 |
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| CN201480062149.0A Pending CN105722860A (zh) | 2013-09-24 | 2014-09-24 | 白介素-2融合蛋白及其应用 |
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| US (3) | US10781242B2 (fr) |
| EP (1) | EP3049445A4 (fr) |
| JP (2) | JP2016533167A (fr) |
| CN (1) | CN105722860A (fr) |
| CA (1) | CA2925421C (fr) |
| WO (1) | WO2015042707A1 (fr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2925421C (fr) * | 2013-09-24 | 2023-08-29 | Medicenna Therapeutics, Inc. | Proteines hybrides de l'interleukine-2 et leurs utilisations |
| JP6592505B2 (ja) | 2014-04-24 | 2019-10-16 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | インターロイキン−２のスーパーアンタゴニスト、パーシャルアゴニスト及びアンタゴニスト |
| US11446398B2 (en) | 2016-04-11 | 2022-09-20 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| KR102623244B1 (ko) | 2016-12-21 | 2024-01-09 | 주식회사 엔케이맥스 | 면역 세포 및 포나티닙을 포함하는 약학 조성물 및 방법 |
| JP2020515289A (ja) * | 2017-03-24 | 2020-05-28 | オルフェウス バイオサイエンス インコーポレイテッド | 自己免疫障害の治療のためのｐａｎｔｉｄ |
| EP3641814A4 (fr) | 2017-06-19 | 2021-06-23 | Medicenna Therapeutics Inc. | Utilisations et procédés pour des superagonistes et agonistes d'il-2 et des fusions de ceux-ci |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| US20200246420A1 (en) * | 2019-01-28 | 2020-08-06 | Rhode Island Council On Postsecondary Education | pHLIP® peptide-mediated epitope tethering at cell surfaces |
| JP2023515247A (ja) | 2020-03-31 | 2023-04-12 | ハンミ ファーマシューティカル カンパニー リミテッド | 新規な免疫活性インターロイキン２アナログ |
| WO2023004368A1 (fr) * | 2021-07-21 | 2023-01-26 | Trutino Biosciences Inc. | Polypeptides lieurs |
| WO2023133595A2 (fr) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Méthodes de dosage et d'administration ex vivo de particules lipidiques ou de vecteurs viraux ainsi que systèmes et utilisations associés |
| WO2023170475A2 (fr) * | 2022-03-08 | 2023-09-14 | Medicenna Therapeutics, Inc. | Utilisations et procédés pour molécules bifonctionnelles de cytokine d'il-2, d'il-13 et d'il-4 |
| WO2023193015A1 (fr) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Polythérapies d'agoniste de récepteur de cytokine et de vecteur viral |
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| US6011002A (en) * | 1994-04-08 | 2000-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Circularly permuted ligands and circularly permuted chimeric molecules |
| CN1299417A (zh) * | 1998-03-02 | 2001-06-13 | 耶路撒冷希伯来大学伊森姆研究发展公司 | 具有细胞靶向特异性和诱导凋亡活性的嵌合蛋白 |
| WO2008039173A2 (fr) * | 2005-09-09 | 2008-04-03 | Government Of The United States Of Amercica, As Represented By The Secretary, Department Of Health And Human Services | Procédés et compositions pour inhiber la mort des cellules ou renforcer la prolifération des cellules |
| WO2012054929A2 (fr) * | 2010-10-22 | 2012-04-26 | Protox Therapeutics Corp. | Utilisation d'albumine sérique humaine pour diminuer l'immunogénicité de protéines thérapeutiques |
| WO2012088446A1 (fr) * | 2010-12-22 | 2012-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Super-agonistes et antagonistes de l'interleukine-2 |
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| US4816249A (en) | 1981-11-17 | 1989-03-28 | The Board Of Trustees Of The Leland Stanford Junior University | Monoclonal anti-idiotype antibodies |
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2019
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2020
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2015042707A1 (fr) | 2015-04-02 |
| US11680090B2 (en) | 2023-06-20 |
| JP2016533167A (ja) | 2016-10-27 |
| US10781242B2 (en) | 2020-09-22 |
| CA2925421C (fr) | 2023-08-29 |
| EP3049445A1 (fr) | 2016-08-03 |
| US20160229901A1 (en) | 2016-08-11 |
| EP3049445A4 (fr) | 2017-10-25 |
| JP2020005655A (ja) | 2020-01-16 |
| US20240067689A1 (en) | 2024-02-29 |
| CA2925421A1 (fr) | 2015-04-02 |
| US20210246183A1 (en) | 2021-08-12 |
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