CN1057191A

CN1057191A - Nourishing skin cream

Info

Publication number: CN1057191A
Application number: CN 91104465
Authority: CN
Inventors: 薛乐勋
Original assignee: HENAN MEDICAL UNIV
Current assignee: HENAN MEDICAL UNIV
Priority date: 1991-06-29
Filing date: 1991-06-29
Publication date: 1991-12-25

Abstract

The present invention relates to a kind of nourishing skin cream, it be soy yogurt with Lactobacillus acidophilus's fermenting process of preparing as substrate, other is added with emollient, emulsifying agent, sucrose alcohol, neutrality or compositions such as negative polysaccharide and water.Advantage of the present invention is: it not only contains the multiple free amino acid to the human body beneficial, lubricate the vegetalitas unsaturated fatty acid that reaches conditioning functions but also contain a large amount of skin is had, to improving the skin-nourishing situation, promote skin metabolism, the delaying human body skin aging has obvious effect.This product raw material sources are wide, and preparation technology is easy, can obtain than the large economy benefit.

Description

Nourishing skin cream

The present invention relates to a kind of cosmetics, relate in particular to a kind of protective skin cream that skin is had nutrition health-care functions.

The horny layer of the outermost layer meaning of human skin, this confluent monolayer cells are a kind of dead cells with regard to its function.The stratum germinativum epidermidis of epidermis innermost layer has 10～20 cells thick approximately.The regenerative cell that constantly comes off promptly by stratum germinativum epidermidis of outer dead cell replaces.If the displaced speed of regenerative cell slows down, the skin aging phenomenon just appears.For a long time, cosmetics designer and medical investigator are in the method for inquiring into delaying decrepitude of skin.

Proved already that lactobacillus was the health care antibacterial healthy and helpful to animal and human's body, these antibacterials can digest Lac Bovis seu Bubali or bean protein of milk in advance owing to its proteolysis, so the free amino acid showed increased in the fermentation milk.Lactobacillus can produce Lactose enzyme between yeast phase, the lactose hydrolysis in Ruzhong can be become galactose and glucose, and the latter is synthesizing lactic acid further, thereby the lactates in the fermentation milk is increased.In the incubation, some lactobacillus can synthesize many vitamin B group, as vitamin B1, riboflavin, nicotinic acid, pantothenic acid, folic acid, vitamin B6 and B12, therefore in the fermentation milk said vitamin content apparently higher than common not fermentation milk, in addition, lactobacillus fermented product has antitumor action, and some lactobacillus can also synthesize certain antibiotic.In view of above-mentioned reason, more existing patents, as French Patent (FRP) FR2411001, Japan Patent J58198409 and DRP DT2630560, the cultured milk that the animal milk (as Lac Bovis seu Bubali) of employing lactobacillus fermentation is made is as the component of cosmetics for skin.But for various reasons, this cosmetics are not implemented in China.

The object of the present invention is to provide the cosmetics of a kind of soy yogurt by Lactobacillus acidophilus Xia Hani strain fermenting process of preparing as substrate, it not only contains a large amount of multiple free amino acids, but also contain lecithin, unsaturated fatty acids such as multiple vitamin B group of vitamin E and Palmic acid, linoleic acid, oleic acid, inferior acid.So skin is had the lubricated usefulness of good nutrition, but delaying decrepitude of skin reduces facial wrinkles.

The object of the present invention is achieved like this: with the soy yogurt of Lactobacillus acidophilus Xia Hani strain fermenting process of preparing as substrate, other is added with emollient 20.0～28.0%, emulsifying agent 5.0～8.0%, sucrose alcohol 1.0～4.5%, neutral or negative polysaccharide 0.4～0.8% and water (deionized water or distilled water), essence 0.1～0.3%, antiseptic (propyl group-P-carboxyl benzoate) 0.1～0.12%.

Among the present invention, the soy yogurt composition accounts for 20～30% of formulation weight; Emollient is optional with water solublity and fat-soluble emollient, as stearic acid, vaseline, mineral oil, lanoline, hexadecanol, dimethyl polysiloxane, isopropyl palmitate, linoleic acid isopropyl ester, propylene glycol, glycerol etc.; Emulsifying agent can be selected glyceryl monostearate for use.Increase in the viscoelastic material, should select a kind of sucrose alcohol for use at least, as sorbitol or mannitol.Neutral or negative polysaccharide also can increase viscoelasticity, answers first-selected methylcellulose (carboxymethyl cellulose), and other macromolecule polysaccharide also can adopt as pectin, alginate.In addition, also can add titanium dioxide in this cosmetic formulations as brightening agent.

Advantage of the present invention is that it not only contains multiple free amino acid, vitamin E, multiple vitamin B group to the human body beneficial, but also contains the vegetalitas unsaturated fatty acid that in a large number skin is had lubricated and conditioning functions.Improving skin-nourishing, promoting skin metabolism, the delaying decrepitude of skin aspect has obvious effect.

Embodiment 1

Skin-nourishing prescription for skin cream according to the present invention's preparation is as follows:

Component A(water)

Soy yogurt 25.00%

Sorbitol 1.50

Carboxymethyl cellulose 0.50

Carbamide 3.00

Triethanolamine 0.28

Sodium lauryl sulphate 0.10

Propylene glycol 2.00

Sodium lactate 0.52

Water 42.08

B component (oil phase)

Hexadecanol 4.00

Stearic acid 8.00

Liquid paraffin 1.50

White vaseline 5.00

Glyceryl monostearate 6.00

Component C

Titanium dioxide 0.10

Essence 0.30

Propyl group-P-carboxyl benzoate 0.12

Preparation method

Water and oil phase are prepared respectively.Water-phase component except that soy yogurt may be dissolved in the hot water, and water temperature is approximately 90 ℃, stirs evenly with soy yogurt then, continues heating, and temperature remains on 85～90 ℃, 15 minutes.After the ultrasonic grinding machine was handled 5 minutes, water (component) promptly prepares and finishes.The oil phase component heating of putting together when temperature rises to 75～80 ℃, can form uniform mixture.After biphase preparation finishes, oil phase is pumped into aqueous phase lentamente, stir rapidly simultaneously, when temperature is reduced to 35～40 ℃, add component C, continue to be stirred to semi-solid and get final product.The PH of finished product is 6.0～6.5.

Embodiment 2

A kind of oil-in-water type nourishing skin cream that contains soy yogurt is the semi-solid cream frost body of being made by following set of dispense, it is a kind of skin protection cosmetics base material, wherein can add some Rhizoma Phragmitis and Flos Chrysanthemi hybrid extraction liquid, make sun-proof nourishing skin cream with anti-sunlight function.

Component A(water)

Soy yogurt 20.00(%)

Sorbitol 1.00

Carboxymethyl cellulose 0.30

Carbamide 3.00

Triethanolamine 0.38

Sodium lauryl sulphate 0.12

Propylene glycol 1.10

Sodium lactate 0.52

Rhizoma Phragmitis, Flos Chrysanthemi hybrid extraction liquid 9.20

Water 41.26

B component (oil phase)

Stearic acid 10.00

Hexadecanol 6.00

Lanoline 0.50

White oil (50 ℃ of 11 centipoises) 0.80

Glyceryl monostearate 5.50

Component C

Essence 0.20

Propyl group-P-carboxyl benzoate 0.12

Preparation method

As described in embodiment 1, oil phase and water prepare respectively.Thereafter oil phase is slowly pumped into aqueous phase, stir rapidly simultaneously, when treating that temperature is reduced to 40 ℃ of left and right sides, add component C, continue to be stirred to the semi-solid cream frost body that forms homogenizing.

Embodiment 3

This example is on embodiment 1 basis, adds hyaluronic acid and the nourishing skin cream made.

Component A(water)

Soy yogurt 20.00(%)

Sodium lauryl sulphate 0.10

Triethanolamine 0.38

Propylene glycol 1.00

Glycerol 2.00

Sorbitol 1.00

Sodium lactate 0.52

Water 22.58

B component (oil phase)

Stearic acid 10.00

Liquid paraffin 1.50

White vaseline 5.00

Glyceryl monostearate 5.50

Component C

Essence 0.30

Propyl group-P-carboxyl benzoate 0.12

0.1% crest hyalomitome acid solution 30.00

Preparation method

Aqueous phase preparation method is seen embodiment 1.The oil phase component Hybrid Heating when temperature rises to 80 ℃ of left and right sides, forms uniform mixture.After biphase preparation finishes, oil phase is slowly pumped into aqueous phase, stir rapidly simultaneously.When temperature is reduced to 65 ℃, 0.1% hyalomitome acid solution is added in the aforesaid liquid, stir continuously and healthily, when temperature is reduced to 35～40 ℃, add essence and antiseptic among the component C, be stirred to semi-solid cream frost body fast.

Embodiment 4

With the component appropriate change of the nourishing skin cream of embodiment 1 and add the cosmetics materials that to remove pigmented spots, freckle, promptly can be made into nutrition speckle dispelling facial cream.

Component A(water)

Soy yogurt 20.00(%)

Sorbitol 1.00

Carbamide 3.00

Triethanolamine 0.30

Sodium lactate 0.52

Glycerol 2.50

Water 30.38

B component (oil phase)

Stearic acid 5.00

White vaseline 6.00

Liquid paraffin 8.00

Lanoline 10.00

Bleaching Cera Flava 4.00

Glyceryl monostearate 8.00

Component C

Essence 0.30

Propyl group-P-carboxyl benzoate 0.12

Thujiplicans 0.03

3-hydroxy pyrone 0.80

Disodium edetate 0.05

Preparation method

As described in embodiment 1, after water, oil phase prepare respectively,, when temperature is reduced to 40 ℃ of left and right sides, add component C with two phase component uniform mixing, keep quick stirring, be cooled to room temperature and get final product.

Various pilot project result of the present invention is as follows:

(1), per os acute toxicity test (LD50)

Soy yogurt is made by edible Lactobacillus acidophilus's fermented soybean milk, and does not use any deleterious chemical reagent in this cosmetics preparation process again, so the per os acute toxicity test can be removed from.

(2), local skin toxicity test

6 hairless mouses, cosmetics of the present invention are put the left side skin of back on the skin, and once a day, around continuing, the right side skin of back compares.Observe skin therebetween and change project: rubescent, thickening and desquamation etc.After duration of test and the end, any above-mentioned skin abnormality variation there is no.The result shows that these cosmetics are to the animal skin nonirritant.

(3), mutagenicity test (bone marrow cell micronucleus test)

40 of Kunming mouses, body weight 25 ± 1 grams, after week quarantine, random packet, every group female, male each 5, the free drinking acid soyabean milk of experimental group (ratio of milk and water is 1: 3), negative and positive controls is all freely drunk water.Irritate stomach for the positive control treated animal at the 21st, 22 day twice usefulness cyclophosphamide aqueous solution of test, dosage is 80ml/kg/d, 6 hours whole three treated animals of execution behind the last filling stomach, produce the breastbone marrow cell smear, Giemsa(Jim Sa) dyeing, the oil mirror is observed 1000 polychromatic erythrocytes of every mice down, obtains and respectively organizes micronuclear rates (seeing attached list):

Subordinate list: the micronucleus test result of soy yogurt

※ and negative control group be P＜0.01 relatively

This result of the test shows that soy yogurt can not cause that the micronuclear rates of mammalian somatic cell increases.

(4), eye toxicity test:

12 of healthy rabbits, body weight 2.5～3.0kg, male and female are regardless of, the present invention is diluted with 3 times of sterile salines, this solution of the left eye point of every rabbit, normal saline of right eye point compares, and uses the variation of slit lamp examination conjunctiva, cornea and iris after 48 hours.The eyes that found that these rabbit all do not produce inflammation or stimulation.

(5), the present invention is to the effect of hairless mouse skin

6 hairless mouses, every mouse back both sides are coated with cosmetics of the present invention and the ordinary cosmetics that do not contain soy yogurt respectively and put on the skin, once a day, continue one month, found that, under xerodermatic situation, it is quite smooth to use the present invention to be coated with a side skin surface of putting on the skin, and crack and fold are than being coated with a side much less of putting on the skin with ordinary cosmetics.The reason that produces this species diversity obviously is because the aminoacid that can absorb for Skin Cell, vitamin etc. are rich in the present invention, thereby maintains the normal of (as drying) skin cell metabolism under the mal-condition.

Claims

1, the present invention relates to a kind of nourishing skin cream, it is characterized in that: it be soy yogurt with Lactobacillus acidophilus's fermenting process of preparing as substrate, other is added with emollient, emulsifying agent, sucrose alcohol, neutrality or negative polysaccharide and water, essence, antiseptic is formed.

2, nourishing skin cream according to claim 1 is characterized in that: the used Lactobacillus acidophilus of fermenting process of preparing soy yogurt is Lactobacillus acidophilus Shahani(summer Hani) strain.

3, nourishing skin cream according to claim 1 is characterized in that: each constituent content of nourishing skin cream is (percentage by weight):

Soy yogurt 25.0～30.0%

Emollient 20.0～28.0%

Emulsifying agent 5.0～8.0%

Sucrose alcohol 1.0～4.5%

Neutral or negative polysaccharide 0.4～0.8%

Essence 0.1～0.3%

Antiseptic 0.1～0.12%

Surplus is a water

4, according to claim 1 or 3 described nourishing skin creams, it is characterized in that: emollient is selected following one or more chemical compounds for use: linoleic acid isopropyl ester, lanoline, hexadecanol, stearic acid, liquid paraffin, white vaseline, dimethyl polysiloxane, isopropyl palmitate, propylene glycol, glycerol etc.

5, according to claim 1 or 3 described nourishing skin creams, it is characterized in that: emulsifying agent should be selected glyceryl monostearate for use.

6, according to claim 1 or 3 described nourishing skin creams, it is characterized in that: sucrose alcohol can be selected mannitol or sorbitol for use.

7, according to claim 1 or 3 described nourishing skin creams, it is characterized in that: neutral or negative polysaccharide can be selected carboxymethyl cellulose, alginate or pectin for use.

8, according to claim 1 or 3 described nourishing skin creams, it is characterized in that: the pH value of this nourishing skin cream finished product is 6.0-6.5.