CN105693499B - It is a kind of that there is analgesia, the jasmine extract of sedative-hypnotic effect - Google Patents
It is a kind of that there is analgesia, the jasmine extract of sedative-hypnotic effect Download PDFInfo
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- CN105693499B CN105693499B CN201610030391.0A CN201610030391A CN105693499B CN 105693499 B CN105693499 B CN 105693499B CN 201610030391 A CN201610030391 A CN 201610030391A CN 105693499 B CN105693499 B CN 105693499B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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Abstract
The invention discloses a kind of jasmine extract with analgesia, sedative-hypnotic effect, its preparation method includes following operation：1) jasmine rhizome, segment crushing are taken, the 0.5% sodium hydrate aqueous solution soak extraction for adding 10~15 times of weight twice, 24 hours every time, is released soak, filtered, merge, obtain filtrate；2) pH value 3.5~4.0 is adjusted, is stood, supernatant is released, obtains lower sediment layer liquid；3) 70 DEG C are heated to, is kept for 10 minutes, filters, water washing, obtains sediment；4) add 300 times of weight purified water, heated by step (3), filter operation twice, obtain Jasmonate dissociate crystalline solid；5) the Jasmonate crystalline solid that dissociates is placed in the ethanol of 100 times of weight, adds soda lye until all into salt, then through filtering, washing, dry, pulverize, sieving, obtain Jasmonate sodium finished product.Jasmonate sodium yield has significant analgesic activity, sedative-hypnotic effect is also notable, and extraction process is easy to operate, pollution-free up to 0.6% in the present invention.
Description
Technical field
It is specifically a kind of that there is analgesia, the jasmine of sedative-hypnotic effect the present invention relates to the technical field of medicinal plant extraction
Jasmine extract.
Background technology
Jasmine is the root, stem, leaf of Oleaceae plants jasmine, is distributed mainly on the ground such as Guangxi, Guangdong, Sichuan.It is wild few,
Mostly family's kind, it is a kind of industrial crops.Make tea-drinking with its flower, claim jasmine tea, or distillate is obtained after being spent distillation, claim jasmine
Jasmine liquid distilled from honeysuckle flowers or lotus leaves, there is the effect of solution all old gas in the heart, invigorating the spleen qi-regulating.There are extensive plantation, shape in the multiple small towns in Hengxian County
Into the industry of certain scale, but only spent with it, Jasmine section is all held every year, to promote the development of Jasmine industry.Make jasmine
Jasmine industry is developed it is necessary to improve the yield of Jasmine, and the yield of Jasmine is relevant with the old and new of plant, new strain flower
More, old strain is spent less, and peasant household is planted for this will excavate old strain, the new strain of transplanting every year, and the old strain excavated is not fully used,
Cause to waste, or even influence the enthusiasm of peasant.
Jasmine rhizome is not Chinese medicine, is arrived as herbal medicine is also rare.Traditional popular prescription is all to take its rhizome (using fresh herb) mill juice to take orally,
Or rhizome is smash into suede wine and fries external application, just there are analgesia, tranquilizing soporific, anesthesia and other effects.The analgesia anesthetic effect of jasmine was last
In the Chinese drug anesthesia research of century the seventies development, also without isolated this kind of monomer component.In recent years, many scholars
The chemical composition of jasmine rhizome is studied, but has currently without discovery and carries out treatment analgesia, town using jasmine extract
The relevant report of quiet hypnosis.
The content of the invention
The technical problems to be solved by the invention be to provide it is a kind of have analgesia, the jasmine extract of sedative-hypnotic effect,
With increase analgesia, the medicament categories of tranquilizing soporific, and waste agronomic crop can be made full use of.
The present invention solves above-mentioned technical problem with following technical scheme：
The present invention have analgesia, sedative-hypnotic effect jasmine extract preparation method, its preparation method include with
Lower operating procedure：
(1) jasmine rhizome is taken, segment crushing, it is water-soluble for 0.5% sodium hydroxide to add 10~15 times of weight, mass concentration
Liquid soak extraction twice, 24 hours every time, stirring frequently or ultrasonic, is released soak, filtered, merge, obtain filtrate；
(2) filtrate is taken, with hydrochloric acid tune pH value to 3.5~4.0, stands, floccule is deposited on bottom, release supernatant,
Obtain lower sediment layer liquid；
(3) a layer beds of precipitation liquid is removed, is heated to 70 DEG C, is kept for 10 minutes, filters, water washing, obtains sediment；
(4) by sediment add 300 times of weight purified water, heated by step (3), filter operation twice, obtain jasmine
The free crystalline solid of jasmine element；
(5) the Jasmonate crystalline solid that dissociates is placed in the ethanol of 100 times of weight, adds soda lye until whole
It into salt, then through filtering, washing, dry, pulverize, sieve, produce Jasmonate sodium finished product.
In step (5), the mass concentration of soda lye is 30~40%.
Jasmine extract of the present invention is according to the special nature of jasmine active component, is sought with the method for zoopery tracking
Look for and determine jasmine analgesic composition.The preparation method of jasmine extract of the present invention is simple to operate, and cost is cheap, to environment hardly
Pollute.
Because Jasmonate episome is unstable, perishable failure, the use of traditional jasmine is all to take using fresh herb, and passes through this
The jasmine extract that inventive method obtains, property is relatively stable, is unlikely to deteriorate failure, and urge with significant analgesia, calmness
Dormancy acts on.
Embodiment
The preparation process of jasmine extract of the present invention is further described with reference to specific embodiment：
It is the specific embodiment of jasmine extract of the present invention below：
Embodiment 1, preparation process is as follows：
(1) rhizome of jasmine aerial part (except flower) is taken to be cut into segment, the machine of dry, pulverize breaks into coarse powder, and it is public that sample weighs 2.4
Jin, 24 hours every time, add 6 times of weight for the first time with the sodium hydrate aqueous solution soak extraction that mass concentration is 0.4% twice
Sodium hydrate aqueous solution soak one day, stir frequently, release soak, second add 4 times of weight sodium hydroxide it is water-soluble
Liquid, operated with method, merge soak, three layers of gauze filtration, obtain filtrate；
(2) filtrate is taken to adjust pH value to stand to 3.5, floccule is deposited on bottom, release supernatant liquor, obtain with watery hydrochloric acid
Lower sediment layer liquid；
(3) the lower sediment layer liquid that step (2) obtains is placed on electric furnace and is heated to 70 DEG C, keeping temperature 10 minutes,
Room temperature is cooled to, incline supernatant, filters, water washing, obtains sediment；
(4) sediment that step (3) obtains is placed in the purified water of 300 times of weight, the operation processing two of same step (3)
It is secondary to obtain the free crystalline solid of Jasmonate；
(5) the Jasmonate crystalline solid that dissociates is placed in the ethanol of 100 times of weight, adds the hydroxide that mass concentration is 30%
Sodium concentrated solution filters until completely into salt, washing, dry, pulverize, and sieves, obtains Jasmonate sodium finished product.
Obtained Jasmonate sodium finished product is ground with 1%CMC-Na, 10mg/ml solution is made into and is administered to mouse stomach,
5mg/ produces lethargic sleep more than 8 hours per mouse.Done experiment again after more than 20 days, lethargic sleep phenomenon no longer occurs, but analgesic activity is very
Substantially, analgesic effect is shown in Table 1.
Embodiment 2, preparation process is as follows：
(1) arabian jasmine root cutting shoots are taken, the machine of dry, pulverize breaks into coarse powder, and sample weighs 2.2 kilograms.It is 0.5% with mass concentration
Sodium hydrate aqueous solution soak extraction twice, 24 hours every time, adds 7 times of weight aqueous sodium hydroxides and soaked 1 day for the first time,
Stir frequently, release maceration extract, second of addition, 5 times of weight aqueous sodium hydroxides immersions, operated with method, merge soak,
Three layers of gauze filter to obtain filtrate；
(2) pH value is adjusted to stand to 4.0, floccule is deposited on bottom, release supernatant, obtain with watery hydrochloric acid filtrate
Lower sediment layer liquid；
(3) the lower sediment layer liquid for taking step (2) to obtain is placed and is heated to 70 DEG C on electric furnace, and keeping temperature 10 minutes is cold
But to room temperature, incline supernatant, filters, water washing, obtains sediment；
(4) sediment that step (3) obtains is placed in the purified water of 300 times of weight, the operation processing two of same step (3)
It is secondary to obtain the free crystalline solid of Jasmonate；
(5) the Jasmonate crystalline solid that dissociates is placed in the ethanol of 100 times of weight, adds the hydroxide that mass concentration is 40%
Sodium concentrated solution is complete up to transition, i.e., filters, washing, dry, pulverize into salt completely, sieving, that is, obtain Jasmonate sodium finished product,
For Jasmonate sodium yield up to 0.6%, analgesic effect is shown in Table 1.
The product Jasmonate sodium Dichlorodiphenyl Acetate of the present invention of table 1 cause mouse writhing reaction influence (N=10)
Compared with blank group：* the pharmaceutical colleges of Guangxi Medical University of P ＜ 0.05, * * P ＜ 0.01
As seen from the above table, Jasmonate sodium of the present invention can significantly inhibit acetic acid induced mice writhing response, have obvious town
Pain acts on.
Claims (1)
1. it is a kind of have analgesia, sedative-hypnotic effect jasmine extract preparation method, it is characterised in that this method include with
Lower operating procedure：
1) jasmine rhizome is taken, segment crushing, it is water-soluble for 0.4~0.5% sodium hydroxide to add 10~15 times of weight, mass concentration
Liquid soak extraction twice, 24 hours every time, stirring frequently or ultrasonic, is released soak, filtered, merge, obtain filtrate；
2) filtrate is taken, adjusts pH value to stand to 3.5~4.0, floccule is deposited on bottom, release supernatant, obtain lower floor with hydrochloric acid
Beds of precipitation liquid；
3) a layer beds of precipitation liquid is removed, is heated to 70 DEG C, is kept for 10 minutes, filters, water washing, obtains sediment；
4) by sediment add 300 times of weight purified water, heated by step (3), filter operation twice, obtain Jasmonate trip
From crystalline solid；
5) the Jasmonate crystalline solid that dissociates is placed in the ethanol of 100 times of weight, adds the hydroxide that mass concentration is 30~40%
Sodium concentrated solution washing, dry, pulverize until all into salt, then through filtering, and sieving, obtain Jasmonate sodium finished product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610030391.0A CN105693499B (en) | 2016-01-18 | 2016-01-18 | It is a kind of that there is analgesia, the jasmine extract of sedative-hypnotic effect |
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| CN201610030391.0A CN105693499B (en) | 2016-01-18 | 2016-01-18 | It is a kind of that there is analgesia, the jasmine extract of sedative-hypnotic effect |
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| CN105693499A CN105693499A (en) | 2016-06-22 |
| CN105693499B true CN105693499B (en) | 2018-01-05 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1524872A (en) * | 2003-02-25 | 2004-09-01 | 敏 洪 | Active ingredient of jasmine root, extracting method and uses thereof |
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- 2016-01-18 CN CN201610030391.0A patent/CN105693499B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1524872A (en) * | 2003-02-25 | 2004-09-01 | 敏 洪 | Active ingredient of jasmine root, extracting method and uses thereof |
Non-Patent Citations (2)
| Title |
|---|
| 茉莉花根对小鼠的镇痛和镇静作用;宁天，梁红;《中药药理与临床》;20141231;第30卷(第2期);99-100页，表1 * |
| 茉莉花根成分及作用研究进展;张园，王玫恒;《实用中医药杂志》;20120228;第28卷(第2期);163页 * |
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