CN105687710A - 一种用于治疗甲状腺机能亢进症的中药胶囊 - Google Patents

一种用于治疗甲状腺机能亢进症的中药胶囊 Download PDF

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CN105687710A
CN105687710A CN201610114272.3A CN201610114272A CN105687710A CN 105687710 A CN105687710 A CN 105687710A CN 201610114272 A CN201610114272 A CN 201610114272A CN 105687710 A CN105687710 A CN 105687710A
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孙宁
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Abstract

本发明公开了一种用于治疗甲状腺机能亢进症的中药胶囊，由以下重量配比的中药材制备而成：柴胡12份、川楝子12份、川芎6份、苍术6份、白芍12份、野百合10份、阿纳其根10份、浙贝母10份、云南琵琶甲8份、幌伞树8份、滇刺枣8份、烟草8份、生牡蛎8份、黄精6份、生地6份、猪靥6份、鹿衔草6份、黄大豆6份、头顶一朵花6份、装饰卷柏6份、黄芪14份、椭圆叶花锚6份、万寿竹5份、铁力木花4份、石胡椒3份、三匹风3份、银杏花粉2份。临床实验证明，本发明通过选择合适的药材及其配比，达到治疗甲状腺机能亢进症的显著功效，且安全无毒副作用。

Description

一种用于治疗甲状腺机能亢进症的中药胶囊
技术领域
本发明涉及一种中药胶囊，具体涉及一种用于治疗甲状腺机能亢进症的中药胶囊。
背景技术
甲状腺机能亢进一症，为现代西医病名，中医归入“瘿病”范畴。典型症状可见甲状腺肿大、突眼症、心律加速，有时可见心律失常，多食易饥，部分患者大便次数增多，但常挟不消化食物，易消瘦及营养不良：中医对此症之认识，为多与气郁痰结有关。疾病初起，证多属实，每见心肝火炽症状。如头痛、眩晕、心烦易怒，目涩口干、失眠多梦。后期证多属虚，而虚中挟实。对于甲状腺机能亢进症的治疗目前尚缺少公认安全有效的药物。
发明内容
本发明旨在提供一种用于治疗甲状腺机能亢进症的中药胶囊及其制备方法，通过选择合适的药材及其配比，达到有助于治疗甲状腺机能亢进症的显著功效，且安全无毒副作用。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗甲状腺机能亢进症的中药胶囊，由以下重量配比的中药材制备而成：柴胡12份、川楝子12份、川芎6份、苍术6份、白芍12份、野百合10份、鲨鱼肝10份、阿纳其根10份、浙贝母10份、云南琵琶甲8份、幌伞树8份、滇刺枣8份、烟草8份、生牡蛎8份、黄精6份、生地6份、猪靥6份、鹿衔草6份、黄大豆6份、头顶一朵花6份、装饰卷柏6份、黄芪14份、椭圆叶花锚6份、万寿竹5份、铁力木花4份、石胡椒3份、三匹风3份、银杏花粉2份。
制备方法为：将上述药材分别去除杂质后混合，送入烘干箱内于120℃温度下烘干，粉碎成100-130目细末，紫外线消毒后按0.5g/粒装入胶囊，即为成品。
本发明各中药成份的药理分析如下：
柴胡【来源】伞形科植物柴胡或狭叶柴胡的干燥根。【功能主治】和解表里，疏肝，升阳。用于感冒发热，寒热往来，胸胁胀痛，月经不调，子官脱垂，脱肛。
川楝子【来源】本品为楝科植物川楝的干燥成熟果实。【性味】苦，寒；有小毒。【归经】归肝、小肠、膀胱经。【功能主治】舒肝行气止痛，驱虫。用于胸胁、脘腹胀痛，疝痛，虫积腹痛。
川芎【来源】伞形科植物川芎的干燥根茎。【性味】辛，温。【归经】归肝、胆、心包经。【功能主治】活血行气，祛风止痛。
苍术【来源】菊科植物茅苍术的干燥根茎。【功能主治】燥湿健脾，祛风散寒，明目。用于脘腹胀满，泄泻，水肿，脚气痿躄，风湿痹痛，风寒感冒，夜盲。
野百合【来源】为豆科植物野百合的全草。【功能主治】清热，利湿，解毒。治痢疾，疮疖，小儿疳积。近试用于治疗癌症。
阿纳其根【来源】为菊科植物罗马除虫菊的根。【性味】味辛辣而麻舌。【功能主治】祛寒强筋，开通阻滞，清除脑中余物，热身壮阳，通利经水，固精，祛风止痛，燥湿化痰，滋补神经。主治湿寒性或豁液质性疾病，如瘫痪，面瘫，肌肉松弛，麻痹，颤动，疮病，舌重，性欲减退，精液不固，经闭不畅，头痛牙痛，多痰咳嗽，神经衰弱。
浙贝母【来源】本品为百合科植物浙贝母的干燥鳞茎。【性味】苦，寒。【归经】归肺、心经。【功能主治】清热散结，化痰止咳，用于风热犯肺，痰火咳嗽，肺痈，乳痈，瘰疬，疮毒。
云南琵琶甲【来源】为拟步行虫科动物云南琵琶甲的全虫。【性味】味咸，性寒。【功能主治】清火解毒，软坚散结，消肿止痛，熄风定惊。主治小儿高热惊风，无名肿毒，腮腺、颌下淋巴结肿痛，湿疹，各种痒症，乳房肿痛，腮腺痛，鼻咽癌，直肠腺癌，淋巴肉瘤，胃脘疼痛。
幌伞树【来源】为五加科植物幌伞树的干燥根及茎。【性味】味苦、涩，性凉。【功能主治】活血，消肿，退热，止痛。治感冒发热，寒热往来，月经失调，崩漏。
滇刺枣【来源】鼠李科植物滇刺枣的树皮和叶。【性味】味涩，微苦。性平。【功能主治】清火解毒，消肿止痛，杀虫止痒，敛水止泻。主治水火烫伤，牙痛，乳房胀痛，疔疮痈疖脓肿，黄水疮，皮肤红疹瘙痒，外阴瘙痒，腹泻，赤白下痢，腹扭痛，刺痛。
烟草【别名】野烟、淡把姑、担不归、金丝烟、相思草、返魂烟、仁草、八角草、烟酒、金毕醺、淡肉要、淡巴菰、鼻烟、水烟、烟草、贪极草、延合草、穿墙草、土烟草、金鸡脚下红、烟叶、土烟【来源】药材基源：为茄科植物烟草的叶。【性味】味辛；性温；有毒。【功能主治】行气止痛；燥湿；消肿；解毒杀虫。主食滞饱胀；气结疼痛；关节痹痛；痈疽；疔疮；疥癣；湿疹；毒蛇咬伤；扭挫伤。
生牡蛎【来源】牡蛎科动物长牡蛎的贝壳。【性味】咸，微寒。【归经】归肝、胆、肾经。【功能主治】重镇安神，潜阳补阴，软坚散结。
生地【来源】本品为玄参科植物地黄的新鲜或干燥块根。【性味】甘，寒。【归经】归心、肝、肾经。【功能主治】清热凉血，养阴，生津。用于热病舌绛烦渴，阴虚内热，骨蒸劳热，内热消渴，吐血，衄血，发斑发疹。
猪靥【来源】为猪科动物猪的甲状腺体。【性味】味甘；性微温；有毒。【归经】肺；胆；膀胱；肾经。【功能主治】散结消瘿。主气瘿；气瘤。
鹿衔草【来源】本品为鹿蹄草科植物鹿蹄草的干燥全草。【性味】甘、苦，温。【归经】归肝、肾经。【功能主治】祛风湿，强筋骨，止血。用于风湿痹痛，腰膝无力，月经过多，久咳劳嗽。
黄大豆【来源】药材基源：为豆科植物大豆的种皮黄色的种子。【性味】甘；平。【归经】脾；心；大肠经。【功能主治】健脾利水；宽中导滞；解毒消肿。主食积泻痢；腹胀食呆；疮痈肿毒；脾虚水肿；外伤出血。
头顶一朵花【来源】药材基源：为报春花科植物管茎过路黄的全草。【性味】酸；苦；性凉。【功能主治】清热解毒；活血消肿。主无名肿毒；毒蛇咬伤；跌打损伤。
装饰卷柏【性味】微苦；凉【来源】药材基源：为卷柏科植物装饰卷柏的全草。【归经】胃；胆；大肠经。【功能主治】清热利湿；通经活络。主肝炎；胆囊炎；痢疾；肠炎；肺痈；风湿性关节炎；烫火伤
黄芪【来源】豆科植物蒙古黄芪的干燥根。【性味】甘，温。【归经】归肺、脾经。【功能主治】补气固表，利尿托毒，排脓，敛疮生肌。
椭圆叶花锚【来源】为龙胆科植物椭圆叶花锚的带花全草。【性味】味苦，性寒。【功能主治】抑协日，清热，疗伤，健胃。主治协日热，肝热，疫热，脏腑热。
万寿竹【来源】为百合科植物万寿竹的根及根茎。【性味】味苦，性冷。【功能主治】润肺止咳，健脾消积。主治咳喘，痰中带血，肠风下血，食积腹胀。
铁力木花【来源】为藤黄科植物铁力木的花。【性味】二级干热，味苦。【功能主治】生干生热，温补心脏，爽心悦志，热身壮阳，燥湿补胃，止泻，敛创，止血消痔。主治湿寒性或黏液质性疾病，如寒性心虚、抑郁症、神经衰弱、身寒阳实，湿性胃虚、腹泻及各种湿创、痔疮出血等。
石胡椒【来源】为胡椒科植物石南藤的茎叶或全株。【性味】味麻、辣，性热。【功能主治】祛风湿，强腰膝，补肾壮阳，止咳平喘，活血止痛。主治风寒湿痹，腰膝酸痛，阳痿，咳嗽气喘，痛经，跌打肿痛。
三匹风【来源】蔷薇科蛇莓属植物蛇莓，以全草入药。【性味】甘、酸，寒。有小毒。【功能主治】清热解毒，散瘀消肿。用于感冒发热，咳嗽，小儿高热惊风，咽喉肿痛，白喉，黄疸型肝炎，细菌性痢疾，阿米巴痢疾，月经过多；外用治腮腺炎，毒蛇咬伤，眼结膜炎，疔疮肿毒，带状疱疹，湿疹。亦可试治癌症。并可用于杀灭孑孓、蝇蛆。
银杏花粉【来源】是经过超微粉碎破壁与抗氧化处理的银杏花粉。【功效】银杏花粉中含有大量的黄酮，内酯等活性物质，对高血压、高血脂等心血管疾病都有一定的治疗效果。因它含有一种高效能的生物活性物质，能改善人体组织器官的新陈代谢，增强心血管功能，延缓衰老，可用作提升人体体力和耐力的增强剂。
黄球花【来源】为豆科植物大叶球花豆的根皮和叶。【性味】味苦、涩，气臭，性凉。【功能主治】祛风除湿，清火解毒，消肿止痛，敛疮排脓。主治牙痛，腮腺、颌下淋巴结肿痛，疔疮痈疖脓肿。
乌韭【来源】鳞始蕨科植物乌蕨的叶及全草。【性味】味苦，性冷。【功能主治】清热，解毒，利湿，止血。主治风热感冒，中暑，泄泻，痢疾，肝炎，白浊，白带，叶血，便血，尿血。
本发明与现有技术相比，具有以下有益效果：
1、本发明中药制剂对于治疗甲状腺机能亢进症治愈率极高且安全无毒副作用，并可预防相关并发症。在配伍应用的情况下，由于药物与药物之间出现相互作用的关系，所以有些药物因协同作用而增进疗效，但是也有些药物却可能互相对抗而抵消、削弱原有的功效；有些药物因为相互配用而减轻或消除了毒性或副作用，但是也有些药物反而因为相互作用而使作用减弱或不利人体的作用等等，即是所谓的单行、相须、相使、相畏、相杀、相恶、相反。中医的复方组成是发挥中药疗效的一种组织形式，它的优越性在于讲究君臣佐使、四气五味升降浮沉，通过药物的有机配合，达到提高药物的疗效，并削弱其不良副作用的目的。就本发明而言，所列药材的组合，既不是药材之间简单的堆砌，也不是同类药效的相加，而是有一定的配伍原则的，配方药材之间配伍严谨，不仅充分利用药物配伍后所产生的协同增效作用，而且避免了药物作用的互相拮杭而抵销或消弱原有的功效，更加注意选用能减轻或消除药物的烈性或毒副作用的药物配伍应用，坚决避免了药物相互配伍产生毒性反应或强烈的副作用。本发明中苍术气味芳香，不仅善长燥湿，更能行气解郁，配以川芎，气血双调，用于多种难治病，有“疏其血气，令其调达，而致和平”之效。以猪靥散结消瘿，柴胡、白芍、川楝子疏肝解郁，野百合益气养阴，鲨鱼肝、阿纳其根、浙贝母健脾化痰，幌伞树、滇刺枣活血消肿，云南琵琶甲、烟草、生牡蛎等软坚散结，佐以椭圆叶花锚、万寿竹、铁力木花、石胡椒等调理五脏，其中椭圆叶花锚健胃保肝，万寿竹润肺健脾，铁力木花温补心脏，石胡椒补肾壮阳，分别顾及脾、肺、心、肝、肾五脏之气阴，减少并发证候，另以银杏花粉增强免疫，全方共奏舒肝清热、益气养阴、化痰散结之功效。通过科学配伍，不仅在病情复杂，瞬息万变的情况下，本发明不仅能有效组织实施合理医治，而且对于防止疾病传变、内侵脏腑还有较好的预防作用，在临床运用上很有价值。
2、本发明中药制剂选用优质中药材制成，所选药材配伍相宜，符合中医药及现代医学研究理论，并利用现代医药制药技术制成，安全无毒副作用，达到标本兼治的目的，值得临床推广应用。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：柴胡12克、川楝子12克、川芎6克、苍术6克、白芍12克、野百合10克、鲨鱼肝10克、阿纳其根10克、浙贝母10克、云南琵琶甲8克、幌伞树8克、滇刺枣8克、烟草8克、生牡蛎8克、黄精6克、生地6克、猪靥6克、鹿衔草6克、黄大豆6克、头顶一朵花6克、装饰卷柏6克、黄芪14克、椭圆叶花锚6克、万寿竹5克、铁力木花4克、石胡椒3克、三匹风3克、银杏花粉2克。制备方法为：将上述药材分别去除杂质后混合，送入烘干箱内于120℃温度下烘干，粉碎成100-130目细末，紫外线消毒后按0.5g/粒装入胶囊，即为成品。
用法用量：口服，每日2次，早晚各1次，每次1粒，饭后温开水送服；30天为1个疗程，连续服用2个疗程。
临床资料：
1、病例选择：
选择在我院诊治的甲状腺机能亢进症患者90例临床观察，临床症状均符合甲状腺机能亢进症诊治标准。病人随机分成治疗组和对照组两组，治疗组48例，对照组42例。治疗组和对照组两组病例的病程、症状轻重程度基本一致，无显著差异，具有可比性。
2、药物选择：
治疗组服用本发明实施例1所制得的中药胶囊制剂，口服，每日2次，早晚各1次，每次1粒，饭后温开水送服；30天为1个疗程。
对照组采用常规西药综合治疗，疗程同治疗组。
连续冶疗2个疗程，对比两组疗效。
3、疗效判定：
（1）基本痊愈：临床症状消失，实验室检查值全部恢复正常。
（2）好转：临床症状明显好转，实验室检查值大部分正常或接近正常。
（3）未愈：临床症状无改善，实验室检查值无好转。
4、结果：
选用本发明实施例1中药胶囊的治疗组中，基本痊愈36例，好转9例，未愈3例，基本痊愈率75.0%，总有效率93.8%。对好转及基本痊愈患者跟踪随访24个月，无1例复发。
对照组中基本痊愈24例，好转10例，未愈8例，基本痊愈率57.1%，总有效率81.0%。对好转及基本痊愈患者跟踪随访24个月，4例复发。
以上结果显示，治疗组的治愈率和总有效率明显高于对照组。
实施例2
称取：柴胡12克、川楝子12克、川芎6克、苍术6克、白芍12克、野百合10克、阿纳其根10克、浙贝母10克、云南琵琶甲8克、幌伞树8克、滇刺枣8克、烟草8克、生牡蛎8克、黄精6克、生地6克、猪靥6克、鹿衔草6克、黄大豆6克、头顶一朵花6克、装饰卷柏6克、西黄芪胶4克、黄芪14克、椭圆叶花锚6克、黄球花12克、乌韭8克、万寿竹5克、铁力木花4克、石胡椒3克、三匹风3克、银杏花粉3克。
制备方法为：将上述药材分别去除杂质后混合，送入烘干箱内于120℃温度下烘干，粉碎成100-130目细末，紫外线消毒后按0.5g/粒装入胶囊，即为成品。
用法用量：口服，每日2次，早晚各1次，每次1粒，饭后温开水送服；30天为1个疗程，连续服用2个疗程。
选用本发明实施例2中药汤剂对在我院诊治的甲状腺机能亢进症14名患者治疗，60天后基本痊愈11例，好转2例，未愈1例，基本痊愈率78.6%，总有效率92.8%。对好转及基本痊愈患者跟踪随访24个月，无1例复发。
显然，本发明的上述实施例仅仅是为清楚地说明本发明所作的举例，而并非是对本发明的实施方式的限定。相关中药及其药理通过现有公开文献及网络均可获得，也可以用相近功效的药材代之代用。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无法对所有的实施方式予以穷举。凡是属于本发明的技术方案所引伸出的显而易见的变化或变动仍处于本发明的保护范围之列。

Claims (1)

1.一种用于治疗甲状腺机能亢进症的中药胶囊，其特征在于，由以下重量配比的中药材制备而成：柴胡12份、川楝子12份、川芎6份、苍术6份、白芍12份、野百合10份、阿纳其根10份、浙贝母10份、云南琵琶甲8份、幌伞树8份、滇刺枣8份、烟草8份、生牡蛎8份、黄精6份、生地6份、猪靥6份、鹿衔草6份、黄大豆6份、头顶一朵花6份、装饰卷柏6份、黄芪14份、椭圆叶花锚6份、万寿竹5份、铁力木花4份、石胡椒3份、三匹风3份、银杏花粉4份。
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