CN105671942A - Method for preparing medical antibacterial cotton gauze - Google Patents
Method for preparing medical antibacterial cotton gauze Download PDFInfo
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- CN105671942A CN105671942A CN201610004893.6A CN201610004893A CN105671942A CN 105671942 A CN105671942 A CN 105671942A CN 201610004893 A CN201610004893 A CN 201610004893A CN 105671942 A CN105671942 A CN 105671942A
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- Prior art keywords
- cotton gauze
- water
- preparation
- medical antibacterial
- sodium hydroxide
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- 229920000742 Cotton Polymers 0.000 title claims abstract description 80
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 43
- 238000005406 washing Methods 0.000 claims abstract description 16
- 229920001661 Chitosan Polymers 0.000 claims abstract description 15
- 238000012986 modification Methods 0.000 claims abstract description 13
- 238000001125 extrusion Methods 0.000 claims abstract description 11
- 229940092665 tea leaf extract Drugs 0.000 claims abstract description 11
- 238000001291 vacuum drying Methods 0.000 claims abstract description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 75
- 238000002360 preparation method Methods 0.000 claims description 16
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 claims description 15
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 12
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims description 12
- 230000000845 anti-microbial effect Effects 0.000 claims description 10
- 239000002131 composite material Substances 0.000 claims description 10
- 239000010659 mugwort oil Substances 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 5
- 239000003513 alkali Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 230000008961 swelling Effects 0.000 claims description 5
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 2
- 230000004048 modification Effects 0.000 abstract 1
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
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- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/184—Carboxylic acids; Anhydrides, halides or salts thereof
- D06M13/207—Substituted carboxylic acids, e.g. by hydroxy or keto groups; Anhydrides, halides or salts thereof
- D06M13/21—Halogenated carboxylic acids; Anhydrides, halides or salts thereof
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/02—Cellulose; Modified cellulose
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- D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
- D06M11/32—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond
- D06M11/36—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompounds; Salts derived from anions with an amphoteric element-oxygen bond with oxides, hydroxides or mixed oxides; with salts derived from anions with an amphoteric element-oxygen bond
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The invention discloses a method for preparing medical antibacterial cotton gauze. The method comprises the following steps of: carrying out extrusion pretreatment on cotton gauze; carrying out carboxymethylation modification treatment on the cotton gauze after pretreatment; carrying out water washing comprising the step of washing with water for a plurality of times; carrying out antibacterial treatment comprising the steps of putting the cotton gauze after water washing into water with the bath ratio of 1:25, adding a compound antibacterial agent with the amount 5-8% of the cotton gauze weight and then increasing the temperature to about 40-48 DEG C, wherein the treating time is 2.5-3 h, and the compound antibacterial agent comprises nano titanium dioxide, modified chitosan, armoise oil and a tea leaf extract; carrying out water squeezing comprising the steps of squeezing water of the cotton gauze after antibacterial treatment to make the water content of the cotton gauze be 10-20% of the weight; and drying comprising the steps of putting the cotton gauze after water squeezing into a vacuum drying box and drying. The water absorbing property of the cotton gauze is improved, and moreover, the cotton gauze has a good antibacterial effect.
Description
Technical field
The present invention relates to medical cotton gauze field, particularly relates to the preparation method of a kind of medical antibacterial cotton gauze.
Background technology
As a kind of native cellulose fibre, cotton products are not only loved by the people with its excellent wear behavior, and with the fabulous affinity of itself and human body, one of medical base material becoming widespread use. Medical cotton gauze is the product widely used both at home and abroad, for transudate in the body in cleaning skin or the surface of a wound, absorption surgical procedure, nurse together with common drug with the surface of a wound and surgical procedure supports organ, tissue etc., the medical cotton gauze that domestic enterprise produces is used widely clinically, and Social benefit and economic benefit is obvious.
But, the microbial resistance of the medical cotton gauze used at present can be poor, and antibacterial effect is not good, and water absorbing properties also has much room for improvement.
Summary of the invention
The technical problem that the present invention mainly solves is to provide the preparation method of a kind of medical antibacterial cotton gauze, it is to increase cotton gauze water absorbing properties, and makes it have good antibacterial effect.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is: the preparation method providing a kind of medical antibacterial cotton gauze, comprises the following steps:
(1) cotton gauze is carried out extrusion pretreatment;
(2) pretreated cotton gauze is carried out carboxymethyl-modification process: adopting sodium hydroxide and Mono Chloro Acetic Acid to carry out carboxymethyl-modification process, the mol ratio of sodium hydroxide and Mono Chloro Acetic Acid is the mass ratio of 2 ~ 2.5:1, Mono Chloro Acetic Acid and cotton gauze is 1.6 ~ 1.8:1;
(3) wash: wash with water for several times, make cotton gauze neither also not contain alkali containing acid;
(4) antimicrobial treatment: the water that the cotton gauze after washing is put into bath raio 1:25, add cotton gauze weight 5 ~ 8% composite antiseptic-germicide, then raised temperature is to about 40 ~ 48 DEG C, treatment time 2.5 ~ 3h, described composite antiseptic-germicide comprises nano titanium oxide, modified chitosan, mugwort oil and tea leaf extract, and the weight proportion of described nano titanium oxide, modified chitosan, mugwort oil and tea leaf extract is 0.1:8:10:5 ~ 7;
(5) water squeezing: the cotton gauze after antimicrobial treatment carried out water squeezing, the water content making cotton gauze is the 10 ~ 20% of its weight;
(6) dry: the cotton gauze after water squeezing is put into vacuum drying oven and dries.
In a preferred embodiment of the present invention, being swelling agent taking sodium hydroxide solution, be 20 ~ 25 DEG C in temperature and carry out extrusion pretreatment in step (1), the mass percent concentration of sodium hydroxide solution is 10% ~ 15%, the treatment time 8 ~ 12min.
In a preferred embodiment of the present invention, in step (2), the mass percent concentration of sodium hydroxide solution is 20 ~ 25%.
In a preferred embodiment of the present invention, step (2) carries out the treatment time 30 ~ 40min of carboxymethyl-modification process.
In a preferred embodiment of the present invention, the washing temperature of step (3) is 35 ~ 45 DEG C.
In a preferred embodiment of the present invention, the particle diameter of the described nano titanium oxide in step (4) is 50 ~ 200nm.
In a preferred embodiment of the present invention, the described modified chitosan in step (4) is cm-chitosan.
In a preferred embodiment of the present invention, in step (4), the bake out temperature of vacuum drying oven is 60 ~ 80 DEG C.
The invention has the beneficial effects as follows: invention increases cotton gauze water absorbing properties, and make it have good antibacterial effect.
Embodiment
It is clearly and completely described to the technical scheme in the embodiment of the present invention below, it is clear that described embodiment is only a part of embodiment of the present invention, instead of whole embodiments. Based on the embodiment in the present invention, those of ordinary skill in the art, not making other embodiments all obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
A preparation method for medical antibacterial cotton gauze, comprises the following steps:
(1) cotton gauze being carried out extrusion pretreatment: take sodium hydroxide solution as swelling agent, be 20 DEG C in temperature and carry out extrusion pretreatment, the mass percent concentration of sodium hydroxide solution is 15%, treatment time 8min;
(2) pretreated cotton gauze is carried out carboxymethyl-modification process: adopt sodium hydroxide and Mono Chloro Acetic Acid to carry out carboxymethyl-modification process, treatment time 40min, the mol ratio of sodium hydroxide and Mono Chloro Acetic Acid is 2:1, the mass percent concentration of sodium hydroxide solution is 25%, and the mass ratio of Mono Chloro Acetic Acid and cotton gauze is 1.6:1;
(3) wash: washing with water for several times, washing temperature is 35 DEG C, make cotton gauze neither also not contain alkali containing acid;
(4) antimicrobial treatment: the water that the cotton gauze after washing is put into bath raio 1:25, add cotton gauze weight 5% composite antiseptic-germicide, then raised temperature is to about 40 DEG C, treatment time 3h, it is 50nm nano titanium oxide, cm-chitosan, mugwort oil and tea leaf extract that described composite antiseptic-germicide comprises particle diameter, and described particle diameter is the weight proportion of 50nm nano titanium oxide, cm-chitosan, mugwort oil and tea leaf extract is 0.1:8:10:6;
(5) water squeezing: the cotton gauze after antimicrobial treatment carried out water squeezing, the water content making cotton gauze is the 20% of its weight;
(6) dry: the cotton gauze after water squeezing being put into vacuum drying oven and dries, bake out temperature is 80 DEG C.
Embodiment 2
A preparation method for medical antibacterial cotton gauze, comprises the following steps:
(1) cotton gauze being carried out extrusion pretreatment: take sodium hydroxide solution as swelling agent, be 25 DEG C in temperature and carry out extrusion pretreatment, the mass percent concentration of sodium hydroxide solution is 10%, treatment time 10min;
(2) pretreated cotton gauze is carried out carboxymethyl-modification process: adopt sodium hydroxide and Mono Chloro Acetic Acid to carry out carboxymethyl-modification process, treatment time 30min, the mol ratio of sodium hydroxide and Mono Chloro Acetic Acid is 2.5:1, the mass percent concentration of sodium hydroxide solution is 20%, and the mass ratio of Mono Chloro Acetic Acid and cotton gauze is 1.8:1;
(3) wash: washing with water for several times, washing temperature is 40 DEG C, make cotton gauze neither also not contain alkali containing acid;
(4) antimicrobial treatment: the water that the cotton gauze after washing is put into bath raio 1:25, add cotton gauze weight 7% composite antiseptic-germicide, then raised temperature is to about 48 DEG C, treatment time 2.5h, it is 100nm nano titanium oxide, cm-chitosan, mugwort oil and tea leaf extract that described composite antiseptic-germicide comprises particle diameter, and described particle diameter is the weight proportion of 100nm nano titanium oxide, cm-chitosan, mugwort oil and tea leaf extract is 0.1:8:10:5;
(5) water squeezing: the cotton gauze after antimicrobial treatment carried out water squeezing, the water content making cotton gauze is the 10% of its weight;
(6) dry: the cotton gauze after water squeezing being put into vacuum drying oven and dries, bake out temperature is 60 DEG C.
Embodiment 3
A preparation method for medical antibacterial cotton gauze, comprises the following steps:
(1) cotton gauze being carried out extrusion pretreatment: take sodium hydroxide solution as swelling agent, be 23 DEG C in temperature and carry out extrusion pretreatment, the mass percent concentration of sodium hydroxide solution is 12%, treatment time 12min;
(2) pretreated cotton gauze is carried out carboxymethyl-modification process: adopt sodium hydroxide and Mono Chloro Acetic Acid to carry out carboxymethyl-modification process, treatment time 35min, the mol ratio of sodium hydroxide and Mono Chloro Acetic Acid is 2.2:1, the mass percent concentration of sodium hydroxide solution is 23%, and the mass ratio of Mono Chloro Acetic Acid and cotton gauze is 1.7:1;
(3) wash: washing with water for several times, washing temperature is 45 DEG C, make cotton gauze neither also not contain alkali containing acid;
(4) antimicrobial treatment: the water that the cotton gauze after washing is put into bath raio 1:25, add cotton gauze weight 8% composite antiseptic-germicide, then raised temperature is to about 44 DEG C, treatment time 2.8h, it is 200nm nano titanium oxide, cm-chitosan, mugwort oil and tea leaf extract that described composite antiseptic-germicide comprises particle diameter, and described particle diameter is the weight proportion of 200nm nano titanium oxide, cm-chitosan, mugwort oil and tea leaf extract is 0.1:8:10:7;
(5) water squeezing: the cotton gauze after antimicrobial treatment carried out water squeezing, the water content making cotton gauze is the 15% of its weight;
(6) dry: the cotton gauze after water squeezing being put into vacuum drying oven and dries, bake out temperature is 70 DEG C.
The useful effect of the preparation method of medical antibacterial cotton gauze of the present invention is: invention increases cotton gauze water absorbing properties, and makes it have good antibacterial effect.
The foregoing is only embodiments of the invention; not thereby the patent scope of the present invention is limited; every utilize description of the present invention to do equivalent structure or equivalence flow process conversion; or directly or indirectly it is used in other relevant technical field, all it is included in the scope of patent protection of the present invention with reason.
Claims (8)
1. the preparation method of a medical antibacterial cotton gauze, it is characterised in that, comprise the following steps:
(1) cotton gauze is carried out extrusion pretreatment;
(2) pretreated cotton gauze is carried out carboxymethyl-modification process: adopting sodium hydroxide and Mono Chloro Acetic Acid to carry out carboxymethyl-modification process, the mol ratio of sodium hydroxide and Mono Chloro Acetic Acid is the mass ratio of 2 ~ 2.5:1, Mono Chloro Acetic Acid and cotton gauze is 1.6 ~ 1.8:1;
(3) wash: wash with water for several times, make cotton gauze neither also not contain alkali containing acid;
(4) antimicrobial treatment: the water that the cotton gauze after washing is put into bath raio 1:25, add cotton gauze weight 5 ~ 8% composite antiseptic-germicide, then raised temperature is to about 40 ~ 48 DEG C, treatment time 2.5 ~ 3h, described composite antiseptic-germicide comprises nano titanium oxide, modified chitosan, mugwort oil and tea leaf extract, and the weight proportion of described nano titanium oxide, modified chitosan, mugwort oil and tea leaf extract is 0.1:8:10:5 ~ 7;
(5) water squeezing: the cotton gauze after antimicrobial treatment carried out water squeezing, the water content making cotton gauze is the 10 ~ 20% of its weight;
(6) dry: the cotton gauze after water squeezing is put into vacuum drying oven and dries.
2. the preparation method of medical antibacterial cotton gauze according to claim 1, it is characterized in that, step (1) is swelling agent taking sodium hydroxide solution, is 20 ~ 25 DEG C in temperature and carries out extrusion pretreatment, the mass percent concentration of sodium hydroxide solution is 10% ~ 15%, the treatment time 8 ~ 12min.
3. the preparation method of medical antibacterial cotton gauze according to claim 1, it is characterised in that, in step (2), the mass percent concentration of sodium hydroxide solution is 20 ~ 25%.
4. the preparation method of medical antibacterial cotton gauze according to claim 1, it is characterised in that, step (2) carries out the treatment time 30 ~ 40min of carboxymethyl-modification process.
5. the preparation method of medical antibacterial cotton gauze according to claim 1, it is characterised in that, the washing temperature of step (3) is 35 ~ 45 DEG C.
6. the preparation method of medical antibacterial cotton gauze according to claim 1, it is characterised in that, the particle diameter of the described nano titanium oxide in step (4) is 50 ~ 200nm.
7. the preparation method of medical antibacterial cotton gauze according to claim 1, it is characterised in that, the described modified chitosan in step (4) is cm-chitosan.
8. the preparation method of medical antibacterial cotton gauze according to claim 1, it is characterised in that, in step (4), the bake out temperature of vacuum drying oven is 60 ~ 80 DEG C.
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| CN111764165A (en) * | 2020-07-06 | 2020-10-13 | 温州大学 | Preparation method of antibacterial drug-loaded gauze and foot cover for diabetic foot patient |
| CN111764165B (en) * | 2020-07-06 | 2022-11-18 | 温州大学 | Preparation method of antibacterial drug-loaded gauze and foot cover for diabetic foot patient |
| CN112080941A (en) * | 2020-08-31 | 2020-12-15 | 中国科学院地球环境研究所 | Preparation method of antibacterial and antiviral titanium dioxide/chitosan melt-blown fabric |
| CN112370566A (en) * | 2020-11-24 | 2021-02-19 | 江西美宝利医用敷料有限公司 | Preparation process of bionic material hemostatic gauze |
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Address after: 214000, No. 12, new stone road, front zone, Huishan Economic Development Zone, Wuxi, Jiangsu Applicant after: Jiangsu Tian Zhang medical and health new material Limited by Share Ltd Address before: 214000, No. 12, new stone road, front zone, Huishan Economic Development Zone, Wuxi, Jiangsu Applicant before: JIANGSU TIANZHANG HEALTH AND MEDICAL NEW MATERIALS CO., LTD. |
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Application publication date: 20160615 |