CN105664290A - Intelligent insulin attaching pump - Google Patents

Intelligent insulin attaching pump Download PDF

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Publication number
CN105664290A
CN105664290A CN201610020026.1A CN201610020026A CN105664290A CN 105664290 A CN105664290 A CN 105664290A CN 201610020026 A CN201610020026 A CN 201610020026A CN 105664290 A CN105664290 A CN 105664290A
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CN
China
Prior art keywords
insulin
shell
lead screw
pump
medicine casket
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201610020026.1A
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Chinese (zh)
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CN105664290B (en
Inventor
阙先进
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Special Leaf Medical Technology Co ltd
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Individual
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Priority to CN201610020026.1A priority Critical patent/CN105664290B/en
Publication of CN105664290A publication Critical patent/CN105664290A/en
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Publication of CN105664290B publication Critical patent/CN105664290B/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M2005/14208Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention discloses an intelligent insulin attaching pump. The intelligent insulin attaching pump comprises a shell, an insulin pumping device and a medicine box provided with a piston, wherein the insulin pumping device and the medicine box are packaged in an inner cavity of the shell, and the insulin pumping device comprises a power component and a transmission component which are connected in sequence; preferably, the power component comprises a micro motor and a gear reducer, and the transmission component comprises a transmission lead screw and a transmission nut; the rotating speed of the micro motor is reduced through the gear reducer, then the transmission lead screw is made to rotate at a low speed, motion is transmitted through the transmission nut so as to make the piston move along the inner wall of the medicine box to extrude and pump an insulin preparation out to be injected into the body of a patient through a subcutaneous remaining needle, the amount of residual liquid is small, hypoglycemia reaction possibly caused by the large length of a connecting pipeline in the prior art can be avoided, and waste of liquid medicine can be avoided so that expenses can be reduced. An output pipe tilting up by 45 degrees is arranged on the upper side of the outer end of the medicine box, an oblique hole inclining by 45 degrees is also formed in the corresponding position of the shell to allow the remaining needle to be inserted therein, and it is guaranteed that the remaining needle is inserted into subskin at 45 degrees too.

Description

A kind of intelligence insulin attaches pump
Technical field
The present invention relates to a kind of Intelligent insulin pump, be specifically related to the pump body structure of a kind of Intelligent insulin pump.
Background technology
In in 1992, a kind of insulin pump has been invented by Medtronic Inc. of the U.S., this pump has a bigger pump housing, it is connected with health by the liquid-transport pipe-line of longer (about 35cm), it is embedded in subcutaneous abdomen by a lienable injection needle, dosage and injection time is injected, with the basal dose of the control software design regulable control insulin in the pump housing by the button control on the Non-follow control pump housing. The relatively subcutaneous manual injection's insulin of this pump has the advantage that 1, can effectively control blood glucose, because having outside the value of the cutting edge of a knife or a sword before the meal injection of every day, also has the injection of the water preparation amount basal insulin of up to a hundred times, effective whole day can control blood glucose in 24 hours. Particularly blood glucose at dawn being raised the patient of phenomenon, what more can effectively control blood glucose raises the infringement to human organ; 2, patient is facilitated to reduce frequency injection. After this pump, patient can change shot position within one to two weeks, greatly reduces manual injection's number of times, improves the quality of life of patient, decreases because injecting the superinfection caused and because injecting the damage that skin is caused. But there is following defect in this pump simultaneously: extremely inconvenient when 1, patient uses, because the pump housing is relatively big, patient is typically all and carries piggyback or hang over loins on the arm, and patient takes exercises, has a bath, all inconvenient in bed, the pump housing does not have water-proof function, more can not significantly move and the sports such as swimming; 2, patients ' privacy can not be protected, every time before the meal injection peak insulin time patient must on the pump housing button press, owing to the pump housing is relatively big, when cool autumn weather in summer, temperature was high, pump housing exposure, patient can not protect ill privacy; 3, expensive, the insulin pump price of current import is all at 4-6 more than ten thousand, and monthly consumptive material is more than 400-600 unit, adds expense burden to patient; 4, hypoglycemia can not effectively be controlled. Longer owing to connecting pipeline, patient in the end change dressings casket time due to external pressure relatively big, residual liquor can disposable entrance subcutaneous, cause excess injection to cause hypoglycemic reaction;5, during piping foundation, waste is relatively big, owing to being that high concentration insulin pumping admixture every milliliter includes 200 units, monthly to change pipeline 2 to 4 times, every secondary waste insulin about 20 to 40 unit.
Summary of the invention
It is an object of the invention to provide the insulin that a kind of integrated level is high, volume is little, lightweight, it is short to connect pipeline, injection volume is accurately controlled and attach pump.
The invention discloses a kind of intelligence insulin and attach pump, it includes shell and the insulin pumping installations being packaged in its inner chamber and the medicine casket with piston, insulin pumping installations includes the power part and the drive disk assembly that are sequentially connected with, the terminal link of drive disk assembly is connected with the piston of medicine casket, makes piston can move along the inwall of medicine casket and insulin preparation extruding is pumped under percutaneous remaining needle injects in the patient.
Described shell is close-shaped U-shaped body, sealed by upper shell U-shaped accordingly and lower house and surround, it is provided with the seal dividing plate parallel with upper and lower casing two parallel side wall between upper shell and lower house and divides the housing into two independent chambers, shell is provided through the U-shaped conduit sealing dividing plate.
Described medicine casket and described power part, drive disk assembly are placed in two chambers of described shell; The piston end of medicine casket inwardly, is provided with the outlet becoming 45 degree of angles, past surface thereof with horizontal plane on the upside of the other end.
Described power part includes the gear reduction box of micromotor and its connection, and micromotor adopts rechargeable high-energy minicell as power supply.
Described drive disk assembly includes drive lead screw, transmission nut and flexible piston rod, flexible piston rod adopts carbon fiber composite materials to make, its one end is inserted in described U-shaped conduit, the piston of the other end and described medicine casket is detachably connected as a single entity, drive lead screw is arranged along the side of U-shaped conduit two parallel side wall, transmission nut is connected on drive lead screw, the sidewall of transmission nut is connected to drive block, on U-shaped conduit, corresponding drive lead screw position offers bar-shaped trough parallel with it, and in drive block insertion bar-shaped trough, the corresponding end-faces with flexible piston rod is connected as a single entity.
Described drive lead screw is as the output shaft of described gear reduction box or is connected with the output shaft of gear reduction box by shaft joint, and the convert rotational motion of drive lead screw is that the rectilinear motion of transmission nut is to promote the piston of flexible piston rod and described medicine casket to move forward.
On described shell, there is the angling hole of respective angles at the outlet place of corresponding described medicine casket outer end, inserts for remaining needle, and angling hole place configures corresponding sealing ring.
There also is provided, in chamber residing for corresponding described power part, the control circuit circuit board being connected to described micromotor in described shell; Shell is connected to the USB interface and illuminating lamp that are connected with panel.
The bottom surface of described housing lower shell is pasted on patient's hypogastric region skin as attaching face by biogum, and the corresponding described medicine casket place of upper shell is provided with slidably seal cover board and is easy to the replacing of medicine casket.
Described shell and U-shaped conduit, to seal dividing plate be one-time formed carbon fiber composite materials single piece, and the corresponding described medicine casket of the inwall of shell, micromachine, gear reduction box and drive lead screw position are respectively arranged with one-time formed corresponding fixed structure.
The present invention utilizes drive lead screw and driving screw-nut structure to be transmission by the convert rotational motion of drive lead screw
The rectilinear motion of nut, promote flexible piston rod again through transmission nut and then promote the piston that medicine casket carries to move forward, insulin preparation extruding in medicine casket is pumped remaining needle under percutaneous inject in the patient, remaining needle is directly connected with the outlet of medicine casket, residual liquor is few, is avoided that prior art is likely to, because connecting pipeline length, the hypoglycemic reaction caused, improves the safety of patient, also it is avoided that the waste of medicinal liquid, saves expense.
In order to make drive lead screw produce low-speed rotation, configuring gear reduction box, the power set of gear reduction box adopt micromachine, so both can meet instructions for use, and can reduce again and take up room.
In order to make power set safety in use, shell is carried out independent partitions, make medicine casket and power set be respectively placed in the separate chamber of shell.
In order to meet hospital to hypodermic working specification, the outlet of medicine casket is set to acclivitous 45 degree of angles, in like manner the corresponding position of shell is also provided with the angling hole of equal angular, for the insertion of remaining needle, so ensures that remaining needle injects subcutaneous inserting needle and is also 45 degree.
For the ease of the replacing of medicine casket, removably connect between the piston of flexible piston rod and medicine casket, offer corresponding slidably seal cover board simultaneously in the upside of shell.
In order to alleviate the weight of whole pump and be easy to attach; carbon fiber composite materials is adopted to make shell and U-shaped conduit, flexible piston rod; the overall weight so attaching pump is very light, can be attached directly on the skin of patient's hypogastric region correct position, and the activity not affecting patient also protects the privacy of patient.
For the ease of controlling the injection volume of medicinal liquid, realize the injection volume of medicinal liquid by controlling the distance of distance and then control medicine casket piston-advance that the rotating speed of micromotor controls transmission nut advance.
Data and the power source charges to micromotor is transmitted also by USB interface.
Accompanying drawing explanation
Fig. 1 is the appearance schematic diagram of a preferred embodiment of the invention.
Fig. 2 is the cross-sectional schematic of Fig. 1.
Fig. 3 is the structural representation of insulin pumping installations in Fig. 2.
Detailed description of the invention
As shown in Figure 1 to Figure 3, present embodiment discloses a kind of intelligence insulin and attach pump, including shell 1 with the insulin pumping installations 2 being packaged in its inner chamber and medicine casket 3. Shell 1 is the U-shaped of totally-enclosed shape, employing carbon fiber makes, sealed by upper shell U-shaped accordingly and lower house and surround, be provided with the seal dividing plate 11 parallel with upper and lower casing two parallel side wall between upper shell and lower house and shell 1 is divided into two independent chambers of size. Being provided through the U-shaped conduit 14 sealing dividing plate 11 in shell 1, its two parallel side wall lays respectively in two chambers of shell 1.
Insulin pumping installations 2 includes micromotor 21, gear reduction box 22, drive lead screw 23, transmission nut 24, flexible piston rod 25.
Micromotor 21 adopts rechargeable high-energy minicell as power supply. Micromotor 21 is as the power set of gear reduction box 22, and the output shaft of gear reduction box 22 is drive lead screw 23, and transmission nut 24 is connected on drive lead screw 23.
The inner of medicine casket 3 is connected on the upside of piston 31, outer end and is connected to the outlet 32 becoming 45 degree of angles, past surface thereof with horizontal plane. Medicine casket 3 is parallel to dividing plate 11 inwardly with piston end and is arranged in the little chamber of shell 1.
Micromotor 21, gear reduction box 22, drive lead screw 23, transmission nut 24 are arranged in the big chamber of shell 1, and drive lead screw 23 is arranged in parallel in the big chamber of shell 1 inner side of U-shaped conduit 14.
The sidewall of transmission nut 24 is connected to drive block 241.
On U-shaped conduit 14, corresponding drive lead screw 23 place offers bar-shaped trough, and drive block 241 inserts in bar-shaped trough. The piston 31 of one end of flexible piston rod 25 and medicine casket 3 is detachably connected as a single entity, the other end inserts in U-shaped conduit 14 and is connected as a single entity with drive block 241.
On shell 1, there is the angling hole 12 of respective angles at outlet 32 place of corresponding medicine casket 3 outer end, inserts for remaining needle, and angling hole 12 place configures corresponding sealing ring, in case Drug leakage.
Shell 1 is arranged in the big chamber of power set and be there also is provided the control circuit circuit board being connected with micromotor 21.
On the upside of shell 1, corresponding medicine casket 3 position is provided with out the seal cover board 13 of slip, it is simple to the replacing of medicine casket 3.
Shell 1 is additionally provided with the USB interface being connected with control circuit circuit board and illuminating lamp (attached not shown in FIG., concrete link position can according to circumstances be determined).
Shell 1 and U-shaped conduit 14, to seal dividing plate 11 be one-time formed carbon fiber composite materials single piece, and the inwall correspondence medicine casket 3 of shell 1, micromachine 21, gear reduction box 22 and drive lead screw 23 position are respectively arranged with one-time formed corresponding fixed structure.
The operation principle of the present embodiment is as follows: utilize the rectilinear motion that the convert rotational motion of drive lead screw is transmission nut by drive lead screw and driving screw-nut structure, promote flexible piston rod again through transmission nut and then promote the piston that medicine casket carries to move forward, insulin preparation extruding in medicine casket is pumped remaining needle under percutaneous inject in the patient, remaining needle is directly connected with the outlet of medicine casket, residual liquor is few, it is avoided that prior art is likely to, because connecting pipeline length, the hypoglycemic reaction caused, improve the safety of patient, also it is avoided that the waste of medicinal liquid, saving expense. in order to make drive lead screw produce low-speed rotation, configuring gear reduction box, the power set of gear reduction box adopt micromachine, so both can meet instructions for use, and can reduce again and take up room. in order to make power set safety in use, shell is carried out independent partitions, make medicine casket and power set be respectively placed in the separate chamber of shell. in order to meet hospital to hypodermic working specification, the outlet of medicine casket is set to acclivitous 45 degree of angles, in like manner the corresponding position of shell is also provided with the angling hole of equal angular, for the insertion of remaining needle, so ensures that remaining needle injects subcutaneous inserting needle and is also 45 degree. for the ease of the replacing of medicine casket, removably connect between the piston of flexible piston rod and medicine casket, offer corresponding slidably seal cover board simultaneously in the upside of shell. in order to alleviate the weight of whole pump and be easy to attach, carbon fiber composite materials is adopted to make shell and U-shaped conduit, flexible piston rod, the overall weight so attaching pump is very light, can be attached directly on the skin of patient's hypogastric region correct position, and the activity not affecting patient also protects the privacy of patient. for the ease of controlling the injection volume of medicinal liquid, it is provided with the control circuit circuit board being connected with micromotor in the enclosure, realizes the injection volume of medicinal liquid by controlling the distance of distance and then control medicine casket piston-advance that the rotating speed of micromotor controls transmission nut advance. data and the power source charges to micromotor is transmitted also by USB interface.

Claims (10)

1. an intelligent insulin attaches pump, it is characterized in that: it includes shell and the insulin pumping installations being packaged in its inner chamber and the medicine casket with piston, insulin pumping installations includes the power part and the drive disk assembly that are sequentially connected with, the terminal link of drive disk assembly is connected with the piston of medicine casket, makes piston can move along the inwall of medicine casket and insulin preparation extruding is pumped under percutaneous remaining needle injects in the patient.
2. intelligence insulin as claimed in claim 1 attaches pump, it is characterized in that: described shell is close-shaped U-shaped body, sealed by upper shell U-shaped accordingly and lower house and surround, it is provided with the seal dividing plate parallel with upper and lower casing two parallel side wall between upper shell and lower house and divides the housing into two independent chambers, shell is provided through the U-shaped conduit sealing dividing plate.
3. intelligence insulin as claimed in claim 2 attaches pump, it is characterised in that: described medicine casket and described power part, drive disk assembly are placed in two chambers of described shell; The piston end of medicine casket inwardly, is provided with the outlet becoming 45 degree of angles, past surface thereof with horizontal plane on the upside of the other end.
4. intelligence insulin as claimed in claim 3 attaches pump, it is characterised in that: described power part includes the gear reduction box of micromotor and its connection, and micromotor adopts rechargeable high-energy minicell as power supply.
5. intelligence insulin as claimed in claim 4 attaches pump, it is characterized in that: described drive disk assembly includes drive lead screw, transmission nut and flexible piston rod, flexible piston rod adopts carbon fiber composite materials to make, its one end is inserted in described U-shaped conduit, the piston of the other end and described medicine casket is detachably connected as a single entity, drive lead screw is arranged along the side of U-shaped conduit two parallel side wall, transmission nut is connected on drive lead screw, the sidewall of transmission nut is connected to drive block, on U-shaped conduit, corresponding drive lead screw position offers bar-shaped trough parallel with it, in drive block insertion bar-shaped trough, the corresponding end-faces with flexible piston rod is connected as a single entity.
6. intelligence insulin as claimed in claim 5 attaches pump, it is characterized in that: described drive lead screw is as the output shaft of described gear reduction box or is connected with the output shaft of gear reduction box by shaft joint, and the convert rotational motion of drive lead screw is that the rectilinear motion of transmission nut is to promote the piston of flexible piston rod and described medicine casket to move forward.
7. intelligence insulin as claimed in claim 6 attaches pump, it is characterised in that: on described shell, there is the angling hole of respective angles at the outlet place of corresponding described medicine casket outer end, inserts for remaining needle, and angling hole place configures corresponding sealing ring.
8. intelligence insulin as claimed in claim 7 attaches pump, it is characterised in that: there also is provided, in chamber residing for corresponding described power part, the control circuit circuit board being connected to described micromotor in described shell; Shell is connected to the USB interface and illuminating lamp that are connected with panel.
9. intelligence insulin as claimed in claim 8 attaches pump, it is characterized in that: the bottom surface of described housing lower shell is pasted on patient's hypogastric region skin as attaching face by biogum, the corresponding described medicine casket place of upper shell is provided with slidably seal cover board and is easy to the replacing of medicine casket.
10. intelligence insulin as claimed in claim 9 attaches pump, it is characterized in that: described shell and U-shaped conduit, to seal dividing plate be one-time formed carbon fiber composite materials single piece, the corresponding described medicine casket of the inwall of shell, micromachine, gear reduction box and drive lead screw position are respectively arranged with one-time formed corresponding fixed structure.
CN201610020026.1A 2016-01-13 2016-01-13 A kind of intelligent insulin attaches pump Active CN105664290B (en)

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Application Number Priority Date Filing Date Title
CN201610020026.1A CN105664290B (en) 2016-01-13 2016-01-13 A kind of intelligent insulin attaches pump

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Application Number Priority Date Filing Date Title
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CN105664290A true CN105664290A (en) 2016-06-15
CN105664290B CN105664290B (en) 2017-09-26

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109414546A (en) * 2016-06-23 2019-03-01 特克法马许可公司 Segmented piston rod for medicine delivery device
CN111870772A (en) * 2020-07-15 2020-11-03 中国科学院大学宁波华美医院 Anti-curling indwelling needle application

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1419459A (en) * 2000-03-24 2003-05-21 诺沃挪第克公司 Flexible piston rod
WO2005072794A2 (en) * 2004-01-29 2005-08-11 M 2 Medical A/S Disposable medicine dispensing device
CN1732027A (en) * 2002-12-23 2006-02-08 M2医药有限公司 Flexible piston rod
WO2006105792A1 (en) * 2005-04-06 2006-10-12 M 2 Medical A/S Method and device for dispensing liquid medicine by means of a reversible electrical motor
TW201103593A (en) * 2009-03-31 2011-02-01 Sanofi Aventis Deutschland Improvements in and relating to a medicament delivery devices
CN102908695A (en) * 2012-09-29 2013-02-06 深圳玉升医疗科技有限公司 Automatic injection pump
CN202859793U (en) * 2012-11-07 2013-04-10 刘玉芹 Medical injector with injecting direction capable of being changed
CN103857427A (en) * 2011-07-25 2014-06-11 普雷斯弗雷克斯股份公司 Fluid dispenser
CN205339727U (en) * 2016-01-13 2016-06-29 阙先进 Attached pump of intelligence insulin

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1419459A (en) * 2000-03-24 2003-05-21 诺沃挪第克公司 Flexible piston rod
CN1732027A (en) * 2002-12-23 2006-02-08 M2医药有限公司 Flexible piston rod
WO2005072794A2 (en) * 2004-01-29 2005-08-11 M 2 Medical A/S Disposable medicine dispensing device
WO2006105792A1 (en) * 2005-04-06 2006-10-12 M 2 Medical A/S Method and device for dispensing liquid medicine by means of a reversible electrical motor
TW201103593A (en) * 2009-03-31 2011-02-01 Sanofi Aventis Deutschland Improvements in and relating to a medicament delivery devices
CN103857427A (en) * 2011-07-25 2014-06-11 普雷斯弗雷克斯股份公司 Fluid dispenser
CN102908695A (en) * 2012-09-29 2013-02-06 深圳玉升医疗科技有限公司 Automatic injection pump
CN202859793U (en) * 2012-11-07 2013-04-10 刘玉芹 Medical injector with injecting direction capable of being changed
CN205339727U (en) * 2016-01-13 2016-06-29 阙先进 Attached pump of intelligence insulin

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109414546A (en) * 2016-06-23 2019-03-01 特克法马许可公司 Segmented piston rod for medicine delivery device
CN111870772A (en) * 2020-07-15 2020-11-03 中国科学院大学宁波华美医院 Anti-curling indwelling needle application
CN111870772B (en) * 2020-07-15 2022-04-26 中国科学院大学宁波华美医院 Anti-curling indwelling needle application

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Effective date of registration: 20210107

Address after: 223800 No.1 Fujian Road, Siyang Economic Development Zone, Suqian City, Jiangsu Province

Patentee after: Jiangsu special leaf Medical Technology Co.,Ltd.

Address before: 410200 Cao Jiatang, yujiapo street, Wangcheng District, Changsha City, Hunan Province

Patentee before: Que Xianjin