CN105664184A - Contrast medium with effect of relieving intestine and stomach spasm and preparing method thereof - Google Patents
Contrast medium with effect of relieving intestine and stomach spasm and preparing method thereof Download PDFInfo
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- 239000002872 contrast media Substances 0.000 title claims abstract description 23
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- 208000005392 Spasm Diseases 0.000 title claims abstract description 17
- 210000000936 intestine Anatomy 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims description 5
- 239000003814 drug Substances 0.000 claims abstract description 32
- 210000000582 semen Anatomy 0.000 claims abstract description 17
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims abstract description 16
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- 235000007034 Carum copticum Nutrition 0.000 claims abstract description 9
- 241000218176 Corydalis Species 0.000 claims abstract description 9
- 239000000725 suspension Substances 0.000 claims abstract description 7
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0404—X-ray contrast preparations containing barium sulfate
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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Abstract
The invention relates to a contrast medium with an effect of relieving intestine and stomach spasm. The contrast medium is composed of, by weight, 50-60 parts of barium sulfate (II type) dry suspension and 3-9 parts of traditional Chinese medicine extract. The traditional Chinese medicine extract is prepared from, by weight, 3-6 parts of illicium verum, 3-9 parts of dried ginger, 3-9 parts of angelica polymorpha maxim, 10-20 parts of microtoena insuavis (hance) prain ex dunn, 3-9 parts of seeds of ajowan-caraway, 5-15 parts of rice sprouts, 5-15 parts of rhizoma atractylodis, 5-15 parts of silkworm excrement, 3-6 parts of fennel, 3-9 parts of semen aesculi, 3-9 parts of litchi Seeds, 3-9 parts of radix bupleuri, 3-9 parts of finger citron and 3-9 parts of rhizoma corydalis. The traditional Chinese medicine is based on the theory of traditional Chinese medicine, and middle warming, cold dispelling, spleen and stomach strengthening, liver-qi stagnation smoothing, qi circulation promoting and pain relieving are taken as the main treatment rules. The intestine and stomach contrast medium containing the traditional Chinese medicine extract is small in toxic and side effect, can achieve the intestine and stomach radiography function, has the effect of relieving intestine and stomach spasm and achieves a hypotonic effect pursued by clinic, and radiography is clear.
Description
Technical field
The present invention relates to containing the medicinal preparation and the technology of preparing thereof that derive from plant, animal or mineral component, particularly to a kind of contrast agent having and releasing the intestines and stomach spasm effect and preparation method thereof.
Background technology
Contrast agent (also known as contrast medium, contrastmedia) is to inject (or taking) chemicals to tissue or organ for strengthening Imaging Study effect. The density of these goods is higher or lower than surrounding tissue, and the contrast of formation shows image with some apparatus. Operand as conventional in x-ray observation, barium sulfate etc.
In clinical gastrointestinal examination practice, good gastrointestinal image effect to be expected, it is necessary to the low Zhang Zaoying of gastrointestinal, better to reach the double contrast of gas, contrast agent. Want to reach low Zhang Xiaoguo, it is necessary to release digestive tract spasm, in order to better smearing gastrointestinal mucosa, thus being conducive to showing tiny pathological changes, being conducive to early diagnosis, early treatment. In current clinic, before patient checks, frequent injectable drug reaches to release cramps of gastrointestinal tract, the effect of low, but this method existing defects, the untoward reaction such as mouth dry, gastrointestinal paralysis, intestinal tympanites can be produced after major part patient's injection, add the misery of patient, be unfavorable for diagnosis and follow-up treatment.
Summary of the invention
It is an object of the invention to provide a kind of contrast agent having and releasing the intestines and stomach spasm effect and preparation method thereof, for reaching object above, the present invention adopts the technical scheme that:
A kind of have the contrast agent releasing the intestines and stomach spasm effect, is made up of according to weight fraction following components:
Barium sulfate (TypeⅡ) dry suspension 50-60 part, Chinese medicine extract 3-9 part;
Described Chinese medicine extract is made up of according to weight fraction following components:
Fructus Anisi Stellati 3-6 part, Rhizoma Zingiberis 3-9 part, turn celery 3-9 part, Herba Pogostemonis 10-20 part, Semen Trachyspermi Ammi 3-9 part, Fructus Setariae Germinatus 5-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Bombyx mori L. 5-15 part, Fructus Foeniculi 3-6 part, Semen Aesculi 3-9 part, Semen Litchi: 3-9 part, Radix Bupleuri 3-9 part, Fructus Citri Sarcodactylis 3-9 part, Rhizoma Corydalis 3-9 part.
On the basis of such scheme, described Chinese medicine extract is made up of according to weight fraction following components:
Fructus Anisi Stellati 5 parts, Rhizoma Zingiberis 6 parts, turn celery 6 parts, Herba Pogostemonis 15 parts, Semen Trachyspermi Ammi 6 parts, Fructus Setariae Germinatus 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Bombyx mori L. 10 parts, Fructus Foeniculi 4 parts, Semen Aesculi 6 parts, Semen Litchi 6 parts, Radix Bupleuri 6 parts, Fructus Citri Sarcodactylis 6 parts, Rhizoma Corydalis 6 parts.
On the basis of such scheme, described Chinese medicine extract is prepared from by following methods:
(1) weigh each component and be ground into fine powder, each component after pulverizing being added in the clear water of 10-12 times amount and soak 4 hours;
(2) 30 minutes are boiled;
(3) filter, discard filtering residue;
(4) filtrate reduced in volume postlyophilization, to obtain final product.
On the basis of such scheme, described has the contrast agent releasing the intestines and stomach spasm effect, is made up of according to weight fraction following components:
Barium sulfate (TypeⅡ) dry suspension 55 parts, Chinese medicine extract 6 parts;
Described Chinese medicine extract is made up of according to weight fraction following components:
Fructus Anisi Stellati 5 parts, Rhizoma Zingiberis 6 parts, turn celery 6 parts, Herba Pogostemonis 15 parts, Semen Trachyspermi Ammi 6 parts, Fructus Setariae Germinatus 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Bombyx mori L. 10 parts, Fructus Foeniculi 4 parts, Semen Aesculi 6 parts, Semen Litchi 6 parts, Radix Bupleuri 6 parts, Fructus Citri Sarcodactylis 6 parts, Rhizoma Corydalis 6 parts.
Chinese medicine extract in the present invention, based on theory of Chinese medical science, with warming spleen and stomach for dispelling cold, invigorating the spleen and regulating the stomach, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain for the main rule for the treatment of; In extract: Fructus Anisi Stellati: warming YANG to expel cold, regulating QI to relieve pain; Rhizoma Zingiberis: warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, warming the lung to resolve fluid-retention; Turn celery: warming spleen and stomach for dispelling cold, regulating QI to relieve pain, deliver and dispel the wind; Herba Pogostemonis: expelling wind and cold; Warming middle-JIAO is regulated the flow of vital energy; Semen Trachyspermi Ammi: dispelling cold and dehumidification, regulate the flow of vital energy appetizing, pain relieving; Five medicines are monarch drug altogether; Fructus Setariae Germinatus: help digestion and in, spleen benefiting and stimulating the appetite; The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, dampness diuretic; Bombyx mori L.: expelling wind and removing dampness, regulating the function of the stomach to resolve the turbidity, promoting blood circulation to restore menstrual flow; Fructus Foeniculi: dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach; Semen Aesculi: depressed liver-energy dispersing and QI regulating, and stomach and alleviating pain; Five medicines are ministerial drug altogether; Semen Litchi: promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving; Radix Bupleuri: reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang, preventing the attack (or recurrence) of malaria of bringing down a fever; Fructus Citri Sarcodactylis: depressed liver-energy dispersing and QI regulating, and stomach and alleviating pain, drying dampness to eliminate phlegm; Rhizoma Corydalis: invigorate blood circulation, circulation of qi promoting, pain relieving; Four medicines are adjuvant drug altogether; 14 medicines share, and play altogether: warming spleen and stomach for dispelling cold, invigorating the spleen and regulating the stomach, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain effect. The gastrointestinal contrast agent containing Chinese medicine extract of the present invention, toxic and side effects is little, is not only able to meet gastrointestinal imaging function, and has releasing cramps of gastrointestinal tract, reaches the clinical low Zhang Xiaoguo pursued, and radiography is clear. Chinese medicine extract warming spleen and stomach for dispelling cold, invigorating the spleen and regulating the stomach, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain, release gastric abscess, gastrointestinal convulsion etc.
Detailed description of the invention
Embodiment 1
A kind of have the contrast agent releasing the intestines and stomach spasm effect, is made up of according to weight fraction following components:
Barium sulfate (TypeⅡ) dry suspension 55 parts, Chinese medicine extract 6 parts;
Described Chinese medicine extract is made up of according to weight fraction following components:
Fructus Anisi Stellati 5 parts, Rhizoma Zingiberis 6 parts, turn celery 6 parts, Herba Pogostemonis 15 parts, Semen Trachyspermi Ammi 6 parts, Fructus Setariae Germinatus 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Bombyx mori L. 10 parts, Fructus Foeniculi 4 parts, Semen Aesculi 6 parts, Semen Litchi 6 parts, Radix Bupleuri 6 parts, Fructus Citri Sarcodactylis 6 parts, Rhizoma Corydalis 6 parts.
Described Chinese medicine extract is prepared from by following methods:
(1) weigh each component and be ground into fine powder, each component after pulverizing being added in the clear water of 10-12 times amount and soak 4 hours;
(2) 30 minutes are boiled;
(3) filter, discard filtering residue;
(4) filtrate reduced in volume postlyophilization, to obtain final product.
During use, take barium sulfate (TypeⅡ) dry suspension and the total 150-300g of Chinese medicine extract according to the above ratio, add water and mix well, concentration 50-80%, oral or clysis with barium.
Model case:
1, field, female, 58 years old, play loss of appetite, upper abdominal pain in April, 2012, feel sick nearly 2 months, melena 1 week, in July, 2012 carries out gastrointestinal image inspection, and patient's stomach spasm is obvious;After the contrast agent of the oral embodiment of the present invention 1 preparation, stomach spasm transference cure, reach low Zhang Xiaoguo. Gastric mucosa pleat and area gastrica structure contrast agent fully smear, develop clear, the scope of abundant lesions showed and the destructiveness of duplicature, clearly display: at the bottom of stomach; It is about the deep ulcer of 2x2.5cm near the visible place's size of body of stomach lesser curvature side. After radiography, patient feels that gastrointestinal is comfortable, and malaise symptoms is alleviated.
2, Lee, man, 42 years old, continue upper abdominal pain occurred in 2 weeks. Having an X-rayed visible gastric retention on an empty stomach, stomach spasm is obvious; The contrast agent of the oral embodiment of the present invention 1 preparation, hence it is evident that relieving cramps of gastrointestinal tract, radiography relatively clearly shows that body of stomach Dou Jiao cuts district's size and is about the ulcer surface of 1x1.5cm, niche outside chamber, and the mucosa around ulcer gets together sign, coat of the stomach is wriggled, expansion ratio is good; Diagnosis is benign gastric ulcer. After radiography, patient feels good.
3, the summer, man, 38 years old, stomachache, more than black February of having blood in stool. Using the contrast enema radiography of the embodiment of the present invention 1 preparation, after coloclysis, spastic colon releases, contrast agent uniform application haustra of colon, duplicature ditch, after per anum injects gas, it is seen that rectum, second shape, the multiple mottled niche in descending colon district, haustra of colon full still can, intestinal wall expansion ratio is good; Diagnosis is ulcerative colitis.
Describing the present invention by way of example above, but the invention is not restricted to above-mentioned specific embodiment, all any changes done based on the present invention or modification belong to the scope of protection of present invention.
Claims (4)
1. one kind has the contrast agent releasing the intestines and stomach spasm effect, it is characterised in that: it is made up of according to weight fraction following components:
Barium sulfate (TypeⅡ) dry suspension 50-60 part, Chinese medicine extract 3-9 part;
Described Chinese medicine extract is made up of according to weight fraction following components:
Fructus Anisi Stellati 3-6 part, Rhizoma Zingiberis 3-9 part, turn celery 3-9 part, Herba Pogostemonis 10-20 part, Semen Trachyspermi Ammi 3-9 part, Fructus Setariae Germinatus 5-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Bombyx mori L. 5-15 part, Fructus Foeniculi 3-6 part, Semen Aesculi 3-9 part, Semen Litchi: 3-9 part, Radix Bupleuri 3-9 part, Fructus Citri Sarcodactylis 3-9 part, Rhizoma Corydalis 3-9 part.
2. according to claim 1 have the contrast agent releasing the intestines and stomach spasm effect, it is characterised in that: described Chinese medicine extract is made up of according to weight fraction following components:
Fructus Anisi Stellati 5 parts, Rhizoma Zingiberis 6 parts, turn celery 6 parts, Herba Pogostemonis 15 parts, Semen Trachyspermi Ammi 6 parts, Fructus Setariae Germinatus 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Bombyx mori L. 10 parts, Fructus Foeniculi 4 parts, Semen Aesculi 6 parts, Semen Litchi 6 parts, Radix Bupleuri 6 parts, Fructus Citri Sarcodactylis 6 parts, Rhizoma Corydalis 6 parts.
3. according to claim 1 and 2 have the contrast agent releasing the intestines and stomach spasm effect, it is characterised in that: described Chinese medicine extract is prepared from by following methods:
(1) weigh each component and be ground into fine powder, each component after pulverizing being added in the clear water of 10-12 times amount and soak 4 hours;
(2) 30 minutes are boiled;
(3) filter, discard filtering residue;
(4) filtrate reduced in volume postlyophilization, to obtain final product.
4. according to claim 4 have the contrast agent releasing the intestines and stomach spasm effect, it is characterised in that: it is made up of according to weight fraction following components:
Barium sulfate (TypeⅡ) dry suspension 55 parts, Chinese medicine extract 6 parts;
Described Chinese medicine extract is made up of according to weight fraction following components:
Fructus Anisi Stellati 5 parts, Rhizoma Zingiberis 6 parts, turn celery 6 parts, Herba Pogostemonis 15 parts, Semen Trachyspermi Ammi 6 parts, Fructus Setariae Germinatus 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Bombyx mori L. 10 parts, Fructus Foeniculi 4 parts, Semen Aesculi 6 parts, Semen Litchi 6 parts, Radix Bupleuri 6 parts, Fructus Citri Sarcodactylis 6 parts, Rhizoma Corydalis 6 parts.
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| CN107551281A (en) * | 2016-12-26 | 2018-01-09 | 王淑霞 | A kind of intestines and stomach acoustic contrast agent suitable for cramps of gastrointestinal tract patient |
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