CN105664091B - 一种健脾健胃、利水消肿的兽用中药组合物、发酵制剂及其应用 - Google Patents
一种健脾健胃、利水消肿的兽用中药组合物、发酵制剂及其应用 Download PDFInfo
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Abstract
本发明公开了一种健脾健胃、利水消肿的兽用中药组合物、发酵制剂及其应用,该中药组合物由以下重量份数的中药组分组成:桑白皮20~40份,陈皮20~40份,大腹皮20~40份,姜皮20~40份,茯苓皮20~40份,柴胡10~20份,山楂20~40份,龙胆草10~20份;发酵制剂主要由复合益生菌和上述重量份数的中药原料混合发酵制成。与原五皮散相比,本发明的兽用中药组合物增强了原处方舒肝、利水、去湿、消肿的效果;增强了胃肠道的消化功能,缓解食欲差和消化不良的症状;增加三味中药后调和了原处方中部分中药的毒副作用,具有舒肝、健脾健胃、利水、去湿、消肿的功效,对各种因素引起的水肿和炎症反应具有显著疗效。
Description
技术领域
本发明属于兽用中药饲料添加剂技术领域,具体涉及一种健脾健胃、利水消肿的兽用中药组合物,同时还涉及一种健脾健胃、利水消肿的兽用中药发酵制剂及其应用。
背景技术
五皮散为《中华人民共和国兽药典》2010版第二部公布的处方,由桑白皮30克,陈皮30克,大腹皮30克,姜皮30克,茯苓皮30克组方。方中茯苓皮具有淡渗利湿、健脾和中功效,为君药;大腹皮下气行水、消胀满,桑白皮肃降肺气、通调水道、泻肺行水,为臣药;陈皮芳香化湿、理气健脾和胃,为佐药,姜皮辛散,通行全身,散随气,为使药。诸药合用,共奏行气、化湿、利水之功。该方具有利尿作用、镇痛抗炎、降低毛细血管通透性和抑菌作用,临床用于治疗各种水肿病。
五皮散在施药时,多为水煎服。将该方用于畜禽防病治病,由于畜禽脾胃结构不同,直接将五皮散作为饲料添加剂使用,效果不佳。如现有技术中,CN103784905A公开了一种治疗猪水肿的中药散剂,由生姜皮、桑白皮、陈皮、大腹皮和茯苓皮组成,按其重量份数计生姜皮1-5份、桑白皮1-5份、陈皮1-5份、大腹皮1-5份、茯苓皮1-5份。该中药散剂的用量为每1g中药散剂混匀于1Kg饲料中让猪自由采食,连用3-5天为一个疗程,口服后通过胃肠吸收达到治疗疾病的目的。但是采用该组方饲喂畜禽,动物的顺应性较差,容易引起畜禽脾胃不适,食欲差及消化不良等症状,不能发挥中药原有的功效。
发明内容
本发明的目的是提供一种健脾健胃、利水消肿的兽用中药组合物。
本发明的第二个目的是提供一种健脾健胃、利水消肿的兽用中药发酵制剂。
本发明的第三个目的是提供一种健脾健胃、利水消肿的兽用中药发酵制剂的应用。
为了实现以上目的,本发明所采用的技术方案是:
一种健脾健胃、利水消肿的兽用中药组合物,由以下重量份数的中药组分组成:桑白皮20~40份,陈皮20~40份,大腹皮20~40份,姜皮20~40份,茯苓皮20~40份,柴胡10~20份,山楂20~40份,龙胆草10~20份。
优选的,所述的健脾健胃、利水消肿的兽用中药组合物,由以下重量份数的中药组分组成:桑白皮30份,陈皮30份,大腹皮30份,姜皮30份,茯苓皮30份,柴胡15份,山楂30份,龙胆草15份。
本发明的健脾健胃、利水消肿的兽用中药组合物中,各中药组分的药性药效如下:
桑白皮:为桑科桑属植物桑的干燥根皮;含有黄酮类如桑素、桑黄酮、桑白皮素等以及具有降压作用的乙酰胆碱类似物成分;性甘、辛、寒,归肺、脾经。功效为泻肺平喘、利水消肿;主治肺热或水饮停肺的胸满喘咳,咳血,水肿,脚气,小便不利。现代药理学研究证明桑白皮具有利尿、镇咳、祛痰、平喘、抗炎、降糖等作用。
陈皮:为芸香科柑橘属植物橘及其栽培变种的成熟果皮;含有挥发油如柠檬烯、月桂烯、松油烯、侧柏烯、辛醛、水芹烯、芳樟烯等有效成分。辛、苦,温;归脾、胃、肺经;功效为理气调中,降逆止呕,燥湿化痰;主治胸膈满闷,脘腹胀痛,不思饮食,呕吐,哕逆,咳嗽痰多,乳痈初起。现代药理学研究表明,陈皮具有促消化、祛痰、平喘、促进免疫功能、抗炎、抗氧化等作用。
大腹皮:为棕榈科槟榔属植物槟榔的果皮;含有儿茶酚,生物碱如槟榔碱、去甲基槟榔碱、槟榔次碱、四氢烟酸等,单宁类如原矢车菊素五聚物、四聚物、三聚物,儿茶素等有效成分。辛,微温;归脾、胃、大肠、小肠经;功效为下气宽中,行水消肿;主治胸腹胀闷,水肿,脚气,小便不利。现代药理学研究表明,大腹皮具有促胃肠动力等作用。
姜皮:又称生姜皮,为姜科姜属植物姜的根茎外皮。性状:呈卷缩不整齐的碎片,质软,有特殊香气,味辣;辛,凉;归脾、肺经;功效为行水消肿;主治水肿初起,小便不利。《食疗本草》:治偏风;《纲目》:消浮肿腹胀痞满,和脾胃,去翳;《医林纂要》:达于皮毛,行水驱风,止汗;《本草汇言》:去表寒,消浮肿,化痞满腹胀之药。
茯苓皮:为多孔菌科卧孔属真菌茯苓菌核的外皮,加工时将茯苓的紫黑外皮削下,阴干或晒干;性状:多呈不规则片状,质较松软,气微,味淡。性平,味甘、淡;功效为利水消肿,主治水湿肿满,小便不利。《纲目》:主水肿肤胀,开水道,开腠理;《医林纂要》:行皮肤之水。
柴胡:为伞形科柴胡属植物柴胡或狭叶柴胡的根;含有挥发油如邻甲氧基苯酚、庚内酯、辛内酯、癸内酯、丁香油酚、十一烷酸内酯等,还含有皂苷类如柴胡皂苷、乙酰柴胡皂苷,黄酮类如芦丁、槲皮素等有效成分。苦、辛,微寒,归肝、胆经;功效为解表退热,疏肝解郁,升举阳气;主治外感发热,寒热往来,疟疾,肝郁胁痛乳胀,头痛头眩,月经不调,气虚下陷之脱肛、子宫垂落、胃下垂。现代药理学研究表明,柴胡具有抗炎、解热、镇静、镇痛、镇咳、保肝、护胃、降血脂、抗菌抗病毒、抗肿瘤、促进代谢等作用。
山楂:为蔷薇科山楂属植物山里红、山楂的成熟果实;含有黄酮类如左旋表儿茶素、绿原酸、枸橼酸、熊果酸、植物甾醇等有效成分;性酸、甘,微温,归脾、胃、肝经。功效为消食健胃,行气散瘀;主治饮食积滞,脘腹胀痛,泄泻痢疾,血瘀痛经、闭经,产后腹痛,恶露不尽,疝气,高脂血症。现代药理学研究证明山楂具有促进消化、增强心血管系统功能、降压、降脂、抗氧化、增强免疫功能、防癌等作用。山东产的山楂又称东查。
龙胆草:又称龙胆,为龙胆科龙胆属植物龙胆、条叶龙胆、三花龙胆和滇龙胆的根和根茎;含有裂环烯醚萜苷类苦味成分如龙胆苦苷、当药苷,生物碱如龙胆碱、龙胆黄碱,还含有三萜类等有效成分;苦,寒,归肝、胆经。功效为清肝胆实火,泻下焦湿热;主治头胀头痛,目赤肿痛,耳聋耳肿,口苦胁痛;湿热黄疸,小便淋痛,阴肿阴痒,带下,热病惊风抽搐。现代药理学研究表明,龙胆草具有保肝、利胆、健胃、抗炎、抗过敏、促进中枢神经系统功能等作用。
本发明的健脾健胃、利水消肿的兽用中药组合物,在原五皮散处方中加入柴胡、山楂、龙胆草三味中药,柴胡有疏散退热,舒肝,升阳之功能,用于感冒发热、寒热往来、疟疾、肝郁气滞、胸肋胀痛、脱肛、子宫脱垂、月经不调;山楂有破气消积、消食化滞、温中健脾、活血化痰之功效;龙胆草有清热燥湿,泻肝胆实火、定惊熄风的作用。上述七味中药按照君臣佐使原则配伍组方,诸药合用共奏化湿利水、舒肝、健脾健胃、去湿消肿之功效,主治由各种因素引起的水肿和炎症反应。
本发明的健脾健胃、利水消肿的兽用中药组合物,采用桑白皮、陈皮、大腹皮、姜皮、茯苓皮、柴胡、山楂、龙胆草共八味中药,按照君臣佐使原则配伍组方,其中,茯苓皮、柴胡为君药,大腹皮、龙胆草为臣药,姜皮为佐药,茯苓皮、山楂为使药;具有舒肝、健脾健胃、利水、去湿、消肿的功效,主治各种因素引起的水肿和炎症反应。与原五皮散相比,本发明的兽用中药组合物增强了原处方舒肝、利水、去湿、消肿的效果;增强了胃肠道的消化功能,缓解食欲差和消化不良的症状;增加三味中药后调和了原处方中部分中药的毒副作用,对各种因素引起的水肿和炎症反应具有显著疗效。
一种健脾健胃、利水消肿的兽用中药发酵制剂,主要由复合益生菌和以下重量份数的中药原料混合发酵制成:桑白皮20~40份,陈皮20~40份,大腹皮20~40份,姜皮20~40份,茯苓皮20~40份,柴胡10~20份,山楂20~40份,龙胆草10~20份。
优选的,所述的健脾健胃、利水消肿的兽用中药发酵制剂,主要由复合益生菌和以下重量份数的中药原料混合发酵制成:桑白皮30份,陈皮30份,大腹皮30份,姜皮30份,茯苓皮30份,柴胡15份,山楂30份,龙胆草15份。
所述复合益生菌主要由枯草芽孢杆菌、乳酸菌、酵母菌组成,枯草芽孢杆菌、乳酸菌与酵母菌的数量比为(1~3):(6~7):(0.5~2)。
所述复合益生菌采用菌液接种,复合益生菌菌液接种量为中药原料总质量的5%~30%;所述复合益生菌菌液的菌浓度为109~1011个/mL。
所述中药原料使用前经粉碎、过筛处理制成中药粉,再进行混合、发酵。过筛是指过50目筛网。
所述发酵的温度为25℃~35℃,发酵的时间为3~7天。优选的,所述发酵采用发酵袋形式。
中药组合物中,各味中药均为植物来源,其有效成份主要集中在细胞内,由于植物细胞壁阻隔,大多数发病动物消化能力弱,内源性消化酶分泌不足,单胃动物缺乏降解木质素的纤维素酶,因此,以原药形式投喂,在动物消化道内不能完全破裂该组合物中各味药物的细胞壁,其有效成份不能释放出来,影响到临床应用效果。
本发明的健脾健胃、利水消肿的兽用中药发酵制剂,主要是由复合益生菌与桑白皮、陈皮、大腹皮、姜皮、茯苓皮、柴胡、山楂、龙胆草共八味中药混合发酵制成的;利用复合益生菌对该中药组合物进行发酵处理,益生菌产生的代谢消化酶(淀粉酶、蛋白酶、脂肪酶和纤维素酶等)可裂解植物细胞壁,其细胞内的有效成份更容易释放出来,提高了生物利用率;同时,在发酵过程中产生大量的益生菌及其代谢产物,促进消化系统保持健康,其代谢产物具有营养支持作用,有利于增强动物的抗病力。
一种上述的健脾健胃、利水消肿的兽用中药发酵制剂在饲料添加剂方面的应用。
所述的应用是将所述发酵制剂按照日用量为2~250g/只添加到畜禽饲料中。优选的,将所得发酵制剂按照日用量分别为240克/只、60克/只、60克/只、2克/只,添加到牛、羊、猪、鸡的饲料中,使其自由采食即可。
具体实施方式
下面结合具体实施方式对本发明作进一步的说明。
具体实施方式中,所用的复合益生菌菌液主要由枯草芽孢杆菌、乳酸菌、酵母菌组成,其共生发酵产生的代谢消化酶主要包括淀粉酶、蛋白酶、脂肪酶和纤维素酶等。
具体实施方式中,所用的山楂均为山东产的山楂(又称东查)。
实施例1
本实施例的健脾健胃、利水消肿的兽用中药组合物,由以下重量份数的中药组分组成:桑白皮30份,陈皮30份,大腹皮30份,姜皮30份,茯苓皮30份,柴胡15份,山楂30份,龙胆草15份。
本实施例的健脾健胃、利水消肿的兽用中药发酵制剂,主要是由复合益生菌和上述的中药组合物混合发酵制成的。具体制备方法包括下列步骤:
1)将各中药原料粉碎后,过50目筛,按配方量混合均匀,得中药混合物;
2)将复合益生菌菌液与步骤1)所得中药混合物混合均匀,装入发酵袋中,在发酵温度35℃条件下,发酵5天,即得;其中复合益生菌菌液的质量为中药混合物质量的15%,复合益生菌菌液的菌浓度为109个/mL,枯草芽孢杆菌、乳酸菌与酵母菌的数量比为3:6:1。
本实施例的健脾健胃、利水消肿的兽用中药发酵制剂,在饲料添加剂方面的应用,具体为:将所得发酵制剂按照日用量分别为240克/只、60克/只、60克/只、2克/只,添加到牛、羊、猪、鸡的饲料中,使其自由采食即可。
实施例2
本实施例的健脾健胃、利水消肿的兽用中药组合物,由以下重量份数的中药组分组成:桑白皮20份,陈皮40份,大腹皮40份,姜皮20份,茯苓皮40份,柴胡20份,山楂20份,龙胆草10份。
本实施例的健脾健胃、利水消肿的兽用中药发酵制剂,主要是由复合益生菌和上述的中药组合物混合发酵制成的。具体制备方法包括下列步骤:
1)将各中药原料粉碎后,过50目筛,按配方量混合均匀,得中药混合物;
2)将复合益生菌菌液与步骤1)所得中药混合物混合均匀,装入发酵袋中,在发酵温度25℃条件下,发酵7天,即得;其中复合益生菌菌液的质量为中药混合物质量的10%,复合益生菌菌液的菌浓度为1010个/mL,枯草芽孢杆菌、乳酸菌与酵母菌的数量比为2:7:1。
本实施例的健脾健胃、利水消肿的兽用中药发酵制剂,在饲料添加剂方面的应用,具体为:将所得发酵制剂按照日用量分别为240克/只、60克/只、60克/只、2克/只,添加到牛、羊、猪、鸡的饲料中,使其自由采食即可。
实施例3
本实施例的健脾健胃、利水消肿的兽用中药组合物,由以下重量份数的中药组分组成:桑白皮40份,陈皮20份,大腹皮20份,姜皮40份,茯苓皮20份,柴胡10份,山楂40份,龙胆草20份。
本实施例的健脾健胃、利水消肿的兽用中药发酵制剂,主要是由复合益生菌和上述的中药组合物混合发酵制成的。具体制备方法包括下列步骤:
1)将各中药原料粉碎后,过50目筛,按配方量混合均匀,得中药混合物;
2)将复合益生菌菌液与步骤1)所得中药混合物混合均匀,装入发酵袋中,在发酵温度37℃条件下,发酵3天,即得;其中复合益生菌菌液的质量为中药混合物质量的30%,复合益生菌菌液的菌浓度为1011个/mL,枯草芽孢杆菌、乳酸菌与酵母菌的数量比为2.5:7:0.5。
本实施例的健脾健胃、利水消肿的兽用中药发酵制剂,在饲料添加剂方面的应用,具体为:将所得发酵制剂按照日用量分别为240克/只、60克/只、60克/只、2克/只,添加到牛、羊、猪、鸡的饲料中,使其自由采食即可。
实施例4-6的健脾健胃、利水消肿的兽用中药组合物,中药组分及重量份数如表1所示。实施例4-6的健脾健胃、利水消肿的兽用中药发酵制剂主要是由复合益生菌和表1所示的中药组合物混合发酵制成的,其制备方法和应用分别同实施例1-3。
表1实施例4-6的兽用中药组合物的组分表(单位:重量份数)
名称 | 实施例4 | 实施例5 | 实施例6 |
桑白皮 | 25 | 35 | 30 |
陈皮 | 35 | 30 | 25 |
大腹皮 | 30 | 25 | 35 |
姜皮 | 35 | 25 | 30 |
茯苓皮 | 25 | 30 | 35 |
柴胡 | 10 | 15 | 20 |
山楂 | 35 | 25 | 30 |
龙胆草 | 20 | 10 | 15 |
实验例1
本实验例对实施例1-6所得兽用中药发酵制剂防治鸡疾病的性能进行检测。实验内容如下:
1、试验材料:817肉鸡,试验场为标准化养殖公司生产基地的,按照公司管理程序正常饲养管理和免疫。肉鸡饲养至22日龄时因气候温差大突发疾病,患病鸡出现精神萎靡,食欲减退或废绝,拉白色米汤样稀便,胸腿肌出血,法氏囊肿大有出血,肾脏肿大出血,花斑肾,严重的鸡群死亡率50%以上。临床诊断疑似传染性法氏囊炎和大肠杆菌混合感染。
2、试验方法:随机选取800只,分为8组,每组100只。试验组设置6个,试验组1-6分别使用实施例1-6所得兽用中药发酵制剂;对比组使用未经发酵处理的传统组方五皮散;对照组不添加中药。饲喂量按每天每只鸡2克计算,加入当日采食量的1/3饲料中,混匀后一次投饲。连续用药7天,每天观察病情并统计记录,结果见表2。
3、实验结果:
表2肉鸡感染鸡法氏囊病的中药防治效果分析
无效/死亡(例) | 有效(例) | 好转(例) | 治愈(例) | 总有效率 | |
试验组1 | 10 | 90 | 50 | 40 | 90% |
试验组2 | 9 | 91 | 40 | 51 | 91% |
试验组3 | 14 | 86 | 44 | 42 | 86% |
试验组4 | 8 | 92 | 42 | 50 | 92% |
试验组5 | 12 | 88 | 44 | 44 | 88% |
试验组6 | 10 | 90 | 47 | 43 | 90% |
对比组 | 20 | 80 | 42 | 38 | 80% |
对照组 | 36 | 64 | 55 | 9 | 64% |
注:疗效判定标准:
治愈:精神状态正常,采食饮水恢复正常,无临床症状。
好转:精神状态明显改善,采食饮水增加,仍有小部分临床症状没有消失。
有效:精神状态有改善,出现采食饮水行为,但是还有部分临床症状。
无效:临床症状加重或没有明显改善,仍出现零星死亡,精神萎靡,食欲废绝等。
4、分析
从表2的数据可以看出,试验组与对照组和对比组相比较,试验组总有效率明显高于对比组和对照组(P<0.05),说明中药发酵制剂五皮散具有显著的舒肝、利胆、健脾健胃、利水祛湿、利尿消肿的功效,在恢复鸡群精神、采食饮水、提高鸡群抗病力,提高成活率和提高饲料报酬方面具有显著效果。
实验例2
本实验例对实施例1-6所得兽用中药发酵制剂防治猪疾病的性能进行检测。实验内容如下:
1、试验材料:某猪场断奶仔猪突然发病,体温升高,精神沉郁,食欲下降甚至绝食,脸部、眼睑水肿并发蓝或黑,发病猪独自伏卧一角呈嗜睡状。病初一肢先出现跛行,而后发展到四肢麻痹卧地不起,体表各部感觉钝弱。疾病后期部分猪只的头顶部、颊部、眼睑等处皮肤高度肿胀,呼吸困难,叫声哑或尖。有的横卧、抽搐,即接近濒死期。临床诊断为猪的水肿病。
2、试验方法:选取50日龄200头仔猪,随机分成8组,每组25头。试验组设置6个,试验组1-6分别使用实施例1-6所得兽用中药发酵制剂;对比组使用未经发酵处理的传统组方五皮散;空白对照组不添加中药。饲喂量按照每头每天60克计算,全天用药加入当日采食量的1/3饲料中,集中一次投饲。连续用药七天,每天观察统计记录,结果见下表3。
3、结果
表3仔猪水肿病治疗效果统计
无效(例) | 有效(例) | 好转(例) | 治愈(例) | 总有效率 | |
试验组1 | 3 | 22 | 14 | 8 | 88% |
试验组2 | 3 | 22 | 13 | 9 | 88% |
试验组3 | 2 | 23 | 14 | 9 | 92% |
试验组4 | 2 | 23 | 15 | 8 | 92% |
试验组5 | 2 | 23 | 14 | 9 | 92% |
试验组6 | 3 | 22 | 12 | 10 | 88% |
对比组 | 4 | 21 | 15 | 6 | 84% |
空白对照组 | 24 | 1 | 1 | 0 | 4% |
注:疗效判定标准:
治愈:精神状态正常,采食饮水恢复正常,无临床症状。
好转:精神状态明显改善,采食饮水增加,仍有小部分临床症状没有消失。
有效:精神状态有改善,出现采食饮水行为,但是还有部分临床症状。
无效:临床症状加重或没有明显改善,体温升高,眼睑水肿,个别死亡。
4、结果总结分析:
试验组开始使用2-3天症状明显改善,食欲增加,6-7天后恢复正常。表现出明显的治疗效果。对照组病情加重,死亡率明显增加。根据临床效果观察,仔猪水肿病临床主要原因是仔猪胃肠道尚未健全,微生物区系容易受到干扰,在各种应激状态下,导致致病性大肠杆菌大量繁殖,产生的水肿毒素经肠道吸收后进入血液,并引起毒血症,导致发病。中兽医认为,仔猪水肿病主要由脾阳虚衰引起的水湿内停,泛滥皮肤所致,治宜健胃健脾、渗湿行气、利水消肿,疏肝利胆,调理肠道微生态平衡。
本发明的兽用中药组合物,药物组成为茯苓皮、桑白皮、陈皮、大腹皮、生姜皮和柴胡、山楂、龙胆草,其中茯苓皮可渗湿利水、健脾、宁心安神,陈皮理气和中、止咳化痰,二药合用行气化湿醒脾共为主药;桑白皮宣降肺气,疏通水道为辅药,主治面目浮肿;生姜皮可以辛散水湿,大腹皮乃槟榔的干燥果皮,下气利水,具有很强的消肿和导水下行作用,柴胡有疏散退热,舒肝,升阳之功能,山楂有破气消积、消食化滞、温中健脾、活血化痰之功效;龙胆草有清热燥湿,泻肝胆实火、定惊熄风的作用。诸药相合,健脾、理气、行水,共奏健脾化湿、利水消肿之功,中药发酵制剂是在上述中药组方基础上添加益生菌经发酵而成,具有调理肠道菌群平衡,提高饲料报酬,增强仔猪抗病力的功效。
从表3的数据可以看出,试验组与对照组和对比组相比较,试验组总有效率明显高于对比组和对照组(P<0.05),说明中药发酵制剂具有显著的舒肝、利胆、健脾健胃、利水祛湿、利尿消肿的功效,在恢复仔猪精神、采食饮水、提高仔猪抗病力,提高成活率和提高饲料报酬方面具有显著效果。
实验例3
本实验例对实施例1-6所得兽用中药发酵制剂防治绵羊疾病的性能进行检测。实验内容如下:
1、试验材料:某绵羊饲养场,出现厌食和精神沉郁,病羊腹泻拉稀,甚至脱水,解剖发现肠道粘膜脱落、出血、坏死,诊断为疑似D型魏氏梭菌感染。
2、试验方法:选取200只10月龄绵羊进行试验。随机分成8组,每组25只。试验组设置6个,试验组1-6分别使用实施例1-6所得兽用中药发酵制剂;对比组使用未经发酵处理的传统组方五皮散;对照组不使用同类中药。饲喂量按照每只每天60克计算,全天用药加入当日采食量的1/3饲料中,集中一次投饲。用药七天,每天观察病情并统计记录,结果见表4。
3、结果
表4绵羊毒血症治疗试验统计
注:根据临床效果观察,判定标准如下:
治愈:精神状态正常,采食饮水恢复正常,无临床症状。
好转:精神状态明显改善,采食饮水增加,仍有小部分临床症状没有消失。
有效:精神状态有改善,出现采食饮水行为,但是还有部分临床症状。
无效:临床症状加重或没有明显改善,拉稀腹泻不止,精神沉郁,不食或食欲下降。
4、结果分析:
绵羊痢疾腹泻临床上常见D型魏氏梭菌感染所致,主要是采食含有治病菌的饲草或饮水,导致消化道菌群失调,脾胃虚脱,肠道粘膜脱落,出血,坏死,拉水样稀便或血便,病羊脱水,消瘦,食欲减退或废绝,严重的甚至死亡。中医认为治宜健胃健脾、渗湿行气、利水消肿、舒肝、利胆,调理肠道微生态平衡。
本发明的兽用中药组合物,药物组成为茯苓皮、桑白皮、陈皮、大腹皮、生姜皮和柴胡、山楂、龙胆草,其中茯苓皮可渗湿利水、健脾、宁心安神,陈皮理气和中、止咳化痰,二药合用行气化湿醒脾共为主药;桑白皮宣降肺气,疏通水道为辅药,主治面目浮肿;生姜皮可以辛散水湿,大腹皮乃槟榔的干燥果皮,下气利水,具有很强的消肿和导水下行作用,柴胡有疏散退热,舒肝,升阳之功能,山楂有破气消积、消食化滞、温中健脾、活血化痰之功效;龙胆草有清热燥湿,泻肝胆实火、定惊熄风的作用。诸药相合,健胃健脾、理气、行水,共奏健胃健脾、行气化湿、利水消肿、涩肠止痢之功。本发明中药发酵制剂是经益生菌发酵而成,除具有传统中药组方的功效外,还具有调理肠道菌群平衡,提高饲料报酬,增强绵羊抗病力的功效。
从表4的数据可以看出,试验组与对照组和对比组相比较,试验组总有效率明显高于对比组和对照组(P<0.05),说明本发明的中药发酵制剂对于防治绵羊D型魏氏梭菌感染,提高饲料报酬,增强绵羊抗病力具有显著效果。
实验例4
本实验例对实施例1-6所得兽用中药发酵制剂防治肉牛疾病的性能进行检测。实验内容如下:
1、试验材料:某肉牛养殖场,由于饲喂过量谷物饲料,导致肉牛出现消化不良,瘤胃积食,胀气。临床出现食欲、反刍、嗳气减少或停止,鼻镜干燥,表现为拱腰、回头顾腹、后肢踢腹、摇尾、卧立不安;触诊时瘤胃胀满而坚实,呈现沙袋样,并有痛感,叩诊呈浊音,听诊瘤胃蠕动音初减弱,以后消失。严重的呼吸困难、呻吟、吐粪水,有时从鼻腔流出。有些因脱水、中毒、衰竭或窒息死亡。
2、试验方法:选取200头12月龄肉牛,随机分成8组,每组25头。试验组设置6个,试验组1-6分别使用实施例1-6所得兽用中药发酵制剂;对比组使用未经发酵处理的传统组方五皮散;对照组不添加药物。饲喂量按照每头每天240克计算,全天用药加入当日采食量的1/3饲料中,集中一次投饲。用药七天,每天观察病情并统计记录,结果见下表5。
3、结果
表5肉牛瘤胃积食治疗效果统计
无效(例) | 有效(例) | 好转(例) | 治愈(例) | 总有效率 | |
试验组1 | 2 | 23 | 14 | 9 | 92% |
试验组2 | 2 | 23 | 13 | 10 | 92% |
试验组3 | 3 | 22 | 14 | 8 | 88% |
试验组4 | 2 | 23 | 15 | 8 | 92% |
试验组5 | 3 | 22 | 13 | 9 | 88% |
试验组6 | 3 | 22 | 12 | 10 | 88% |
对比组 | 4 | 21 | 15 | 6 | 84% |
对照组 | 24 | 1 | 1 | 0 | 4% |
注:疗效判定标准:
根据临床症状表现,将治疗效果分成4个等级。判断治疗效果标准如下:
治愈:精神状态正常,采食饮水恢复正常,无临床症状。
好转:精神状态明显改善,采食饮水增加,仍有小部分临床症状没有消失。
有效:精神状态有改善,出现采食饮水行为,但是还有部分临床症状。
无效:临床症状加重或没有明显改善。
4、结果分析:
肉牛瘤胃积食病是肉牛一种常见的疾病,治宜健胃健脾、渗湿行气、利水消肿,疏肝利胆,调理肠道微生态平衡。本发明的兽用中药组合物,药物组成为茯苓皮、桑白皮、陈皮、大腹皮、生姜皮和柴胡、山楂、龙胆草,其中茯苓皮可渗湿利水、健脾、宁心安神,陈皮理气和中、止咳化痰,二药合用行气化湿醒脾共为主药;桑白皮宣降肺气,疏通水道为辅药,主治面目浮肿;生姜皮可以辛散水湿,大腹皮乃槟榔的干燥果皮,下气利水,具有很强的消肿和导水下行作用,柴胡有疏散退热,舒肝,升阳之功能,山楂有破气消积、消食化滞、温中健脾、活血化痰之功效;龙胆草有清热燥湿,泻肝胆实火、定惊熄风的作用。诸药相合,健脾、理气、行水,共奏健脾化湿、利水消肿之功,本发明的中药发酵制剂是经益生菌发酵而成,增强了调理肠道菌群平衡,提高饲料报酬,增强肉牛抗病力的功效。
从表5的数据可以看出,试验组与对照组和对比组相比较,试验组总有效率明显高于对比组和对照组(P<0.05),说明本发明的中药发酵制剂对于防治肉牛瘤胃积食,提高饲料报酬,增强肉牛抗病力具有显著效果。
Claims (10)
1.一种健脾健胃、利水消肿的兽用中药组合物,其特征在于:由以下重量份数的中药组分组成:桑白皮20~40份,陈皮20~40份,大腹皮20~40份,姜皮20~40份,茯苓皮20~40份,柴胡10~20份,山楂20~40份,龙胆草10~20份。
2.根据权利要求1所述的健脾健胃、利水消肿的兽用中药组合物,其特征在于:由以下重量份数的中药组分组成:桑白皮30份,陈皮30份,大腹皮30份,姜皮30份,茯苓皮30份,柴胡15份,山楂30份,龙胆草15份。
3.一种健脾健胃、利水消肿的兽用中药发酵制剂,其特征在于:主要由复合益生菌和以下重量份数的中药原料混合发酵制成:桑白皮20~40份,陈皮20~40份,大腹皮20~40份,姜皮20~40份,茯苓皮20~40份,柴胡10~20份,山楂20~40份,龙胆草10~20份。
4.根据权利要求3所述的健脾健胃、利水消肿的兽用中药发酵制剂,其特征在于:主要由复合益生菌和以下重量份数的中药原料混合发酵制成:桑白皮30份,陈皮30份,大腹皮30份,姜皮30份,茯苓皮30份,柴胡15份,山楂30份,龙胆草15份。
5.根据权利要求3或4所述的健脾健胃、利水消肿的兽用中药发酵制剂,其特征在于:所述复合益生菌主要由枯草芽孢杆菌、乳酸菌、酵母菌组成,枯草芽孢杆菌、乳酸菌与酵母菌的数量比为(1~3):(6~7):(0.5~2)。
6.根据权利要求3或4所述的健脾健胃、利水消肿的兽用中药发酵制剂,其特征在于:所述复合益生菌采用菌液接种,复合益生菌菌液接种量为中药原料总质量的5%~30%;所述复合益生菌菌液的菌浓度为109~1011个/mL。
7.根据权利要求3或4所述的健脾健胃、利水消肿的兽用中药发酵制剂,其特征在于:所述中药原料使用前经粉碎、过筛处理制成中药粉,再进行混合、发酵。
8.根据权利要求3或4所述的健脾健胃、利水消肿的兽用中药发酵制剂,其特征在于:所述发酵的温度为25℃~35℃,发酵的时间为3~7天。
9.一种如权利要求3所述的健脾健胃、利水消肿的兽用中药发酵制剂在制备饲料添加剂方面的应用。
10.根据权利要求9所述的健脾健胃、利水消肿的兽用中药发酵制剂在制备饲料添加剂方面的应用,其特征在于:将所述发酵制剂按照日用量为2~250g/只添加到畜禽饲料中。
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