CN105663953A - Traditional Chinese medicine powder for treating stroke and facial paralysis - Google Patents

Traditional Chinese medicine powder for treating stroke and facial paralysis Download PDF

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Publication number
CN105663953A
CN105663953A CN201610198559.9A CN201610198559A CN105663953A CN 105663953 A CN105663953 A CN 105663953A CN 201610198559 A CN201610198559 A CN 201610198559A CN 105663953 A CN105663953 A CN 105663953A
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chinese medicine
medicine powder
facial paralysis
traditional chinese
powder
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CN201610198559.9A
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郑尚海
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Huaiyang Zhongke Hanfang Biotechnology Product Factory
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Huaiyang Zhongke Hanfang Biotechnology Product Factory
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Priority to CN201610198559.9A priority Critical patent/CN105663953A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/27Asclepiadaceae (Milkweed family), e.g. hoya
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483Gleditsia (locust)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • A61K36/575Magnolia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

Abstract

The invention provides traditional Chinese medicine powder for treating stroke and facial paralysis. An aim of dredging channels and collaterals is achieved through mutual cooperation of the components so as to realize an effect of treating stroke and facial paralysis. The traditional Chinese medicine powder comprises the following raw materials: ligusticum wallichii, rhizoma kaempferiae, radix angelicae, asarum sieboldii, fructus gleditsiae, borneol, paniculate swallowwort root, small centipeda herb, flos magnoliae and musk. In use, the powder is wrapped with gauze and put into the nasal cavity and inhaled through natural breathing. The raw materials cooperate with each other and together realize an effect of activating blood and relieving stuffy orifices; and according to verifying application to multiple patients, the treatment effect is perfect, and the traditional Chinese medicine powder has relatively good popularization values.

Description

A kind of Chinese medicine powder for treating palsy facial paralysis
Technical field
The invention belongs to Chinese medicine powder goods, specifically a kind of Chinese medicine powder for treating palsy facial paralysis.
Background technology
Apoplexy and facial paralysis are the diseases being common in middle-aged and elderly people, apoplexy, names of disease of tcm, have exogenous wind and endogenous wind point, exogenous wind is because caused by being invaded by exogenous pathogen, saying apoplexy in treatise on Febrile Diseases name; Endogenous wind belongs to diseases caused by internal damage, also known as apoplexy, apoplexy etc. Modern times, commonly referred to as apoplexy, refer to the syndrome similar to wind disease of diseases caused by internal damage more, how because QI and blood is inverse disorderly, brain BI-syndrome involved the blood vessels hinders or blood oozing from the body openings or subcuta neous tissue is in caused by brain. With unexpected confused servant, hemiplegia, numb limbs and tense tendons, stiffness of the tongue in silence, crooked mouth and tongue, hemianesthesia etc. is brain god's disease of main manifestations. And there is onset urgency, change soon, such as the disease of the feature of ailment said due to cold or exposure benefaction number change. Facial paralysis refers generally to facial paralysis, be be principal character with facial expression muscle group dyskinesia a kind of disease, it is a kind of commonly encountered diseases, frequently-occurring disease, and general symptom is facial hemiparalysis, and patient is often most basic to lift the actions such as eyebrow, eye closing, drum mouth and all cannot complete.
The blood vessel that the general cause of disease of palsy facial paralysis is face trophic nerve occurs this spasm to cause nervous tissue's ischemia, edema, suffer oppression and cause a disease because having a cold. Most of patients premorbid Ipsilateral head was subject to cold wind, cold water etc. to stimulate, as blown electric fan, meeting cold water etc. Viral infection sign is had, it is common to suffer from the symptoms such as flu, otitis before and after small part morbidity.
Summary of the invention
The invention provides a kind of Chinese medicine powder for treating palsy facial paralysis, it is by the purpose of the mutual cooperative achievement dredging the meridian between each component, thus reaching the effect for the treatment of apoplexy and facial paralysis.
The present invention realizes above-mentioned purpose by the following technical solutions:
A kind of Chinese medicine powder for treating palsy facial paralysis, it comprises following raw material: Rhizoma Chuanxiong, Rhizoma Kaempferiae, the Radix Angelicae Dahuricae, Herba Asari, Fructus Gleditsia, Borneolum Syntheticum, Radix Cynanchi Paniculati, Herba Centipedae, Flos Magnoliae, Moschus.
The proportioning of described each component is as follows: Rhizoma Chuanxiong 6-9 part, Rhizoma Kaempferiae 6-9 part, Radix Angelicae Dahuricae 6-9 part, Herba Asari 2-3 part, Fructus Gleditsia 6-9 part, Borneolum Syntheticum 2-3 part, Radix Cynanchi Paniculati 6-9 part, Herba Centipedae 6-9 part, Flos Magnoliae 6-9 part, Moschus 2-3 part.
Described a kind of Chinese medicine powder for treating palsy facial paralysis, its making and using method are for and to pulverize above-mentioned raw materials according to corresponding proportioning mix homogeneously, with gauze powder wrapped up during use and fill in nasal cavity, being sucked by general breathing.
In we:
Rhizoma Chuanxiong, qi-activating drug, dispel-wind drug, blood circulation promoting medicine;Blood-activating and qi-promoting, suitable stagnation of blood stasis; Wind-expelling pain-stopping, can control wind syndrome of head headache, rheumatic arthralgia, menoxenia, amenorrhea dysmenorrhea, puerperal the stagnant raw meat pain of the stasis of blood, lump in the abdomen lump, pain in chest and hypochondrium, headache dizziness, traumatic injury; Rhizoma Chuanxiong is the gas medicine in blood, its residence of dangerous speech is pungent to be dissipated, resolving depression, sensible, pain relieving, anemofrigid-damp arthralgia, ulcer sores.
Rhizoma Kaempferiae, acrid in the mouth, warm in nature, nontoxic; Return stomach warp. Warming middle-JIAO for eliminating dampness, promoting the circulation of QI to relieve pain. Warming middle-JIAO, helps digestion, pain relieving. Control trusted subordinate's cold type of pain, stop dyspepsia, traumatic injury, toothache. For septum pectorale distension, coldness and pain in the epigastrium. Diet does not disappear.
The Radix Angelicae Dahuricae, pungent, temperature; Return stomach, large intestine, lung meridian. Dissipate wind dehumidifying, sensible pain relieving, detumescence and apocenosis. For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Herba Asari, pungent, temperature; GUIXIN, lung, kidney channel. Expelling wind and cold, sensible pain relieving, warming the lung to resolve fluid-retention. For anemofrigid cold, headache, toothache, nasal sinusitis of having a stuffy nose, rheumatic arthralgia, phlegm retention is breathed with cough.
Fructus Gleditsia, warm in nature; Pungent, salty; Return lung meridian, large intestine channel. With controlling apoplexy locked mouth, remain unconscious, epilepsy abundant expectoration, close that key is obstructed, sore throat stagnation of phlegm, pertinacious phlegm are not well, constipation due to dry stool; External treatment carbuncle.
Borneolum Syntheticum, pungent, bitter, it is slightly cold; GUIXIN, spleen, lung meridian. Have one's ideas straightened out refreshment, clearing away heat to alleviate pain. Fainting for calentura coma, convulsion, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, and conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.
Radix Cynanchi Paniculati, pungent, temperature; Return liver, stomach warp. Dispel the wind removing dampness, antalgesic-antipruritic. For rheumatic arthralgia, distension of having a stomachache, toothache, lumbago, injury from falling down, urticaria, eczema.
Herba Centipedae, pungent, temperature; Return lung, Liver Channel. Clearing the nasal passage, cough-relieving, for headche due to wind-cold, cough with copious phlegm, have a stuffy nose obstructed, nasal sinusitis watery nasal discharge.
Flos Magnoliae, pungent, temperature; Attach to the lung and stomach meridians. Dispersing wind and cold, clearing the nasal passage. For headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge. On lead in nose, with dispersing wind and cold, therefore clinically for treating the nasal sinusitis disease of the how turbid tears of nose, anosmia, often apply with the compatibility such as the Radix Angelicae Dahuricae, Herba Asari, Radix Saposhnikoviae, Fructus Xanthii.
Moschus, pungent, temperature; GUIXIN, spleen channel. Have one's ideas straightened out refreshment, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain. For calentura coma, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, amenorrhea, abdominal mass, stillborn fetus of having difficult labour, trusted subordinate's sudden pain, carbuncle scrofula, and laryngopharynx swelling and pain falls and flutters the pain of injury, and arthralgia pain is numb.
We are active mainly through dredging, and the sensible effect invigorated blood circulation is gone directly focus, it is achieved the treatment to palsy facial paralysis.
The present invention adopts technique scheme to have the advantages that
Each raw material cooperates complete, and each component realizes sensible effect of invigorating blood circulation jointly, through the checking of many sufferers is used, and excellent treatment effect, there is good promotional value.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
A kind of Chinese medicine powder for treating palsy facial paralysis, it comprises following raw material: Rhizoma Chuanxiong, Rhizoma Kaempferiae, the Radix Angelicae Dahuricae, Herba Asari, Fructus Gleditsia, Borneolum Syntheticum, Radix Cynanchi Paniculati, Herba Centipedae, Flos Magnoliae, Moschus.
The proportioning of described each component is as follows: Rhizoma Chuanxiong 6-9 part, Rhizoma Kaempferiae 6-9 part, Radix Angelicae Dahuricae 6-9 part, Herba Asari 2-3 part, Fructus Gleditsia 6-9 part, Borneolum Syntheticum 2-3 part, Radix Cynanchi Paniculati 6-9 part, Herba Centipedae 6-9 part, Flos Magnoliae 6-9 part, Moschus 2-3 part.
Described a kind of Chinese medicine powder for treating palsy facial paralysis, its making and using method are for and to pulverize above-mentioned raw materials according to corresponding proportioning mix homogeneously, with gauze powder wrapped up during use and fill in nasal cavity, being sucked by general breathing.
Embodiment 1
A kind of Chinese medicine powder for treating palsy facial paralysis, it comprises following raw material: Rhizoma Chuanxiong, Rhizoma Kaempferiae, the Radix Angelicae Dahuricae, Herba Asari, Fructus Gleditsia, Borneolum Syntheticum, Radix Cynanchi Paniculati, Herba Centipedae, Flos Magnoliae, Moschus.
The proportioning of described each component is as follows: Rhizoma Chuanxiong 6 parts, Rhizoma Kaempferiae 6 parts, the Radix Angelicae Dahuricae 6 parts, Herba Asari 2 parts, Fructus Gleditsia 6 parts, Borneolum Syntheticum 2 parts, Radix Cynanchi Paniculati 6 parts, Herba Centipedae 6 parts, Flos Magnoliae 6 parts, 2 parts of Moschus.
Described a kind of Chinese medicine powder for treating palsy facial paralysis, its making and using method are for and to pulverize above-mentioned raw materials according to corresponding proportioning mix homogeneously, with gauze powder wrapped up during use and fill in nasal cavity, being sucked by general breathing.
Embodiment 2
A kind of Chinese medicine powder for treating palsy facial paralysis, it comprises following raw material: Rhizoma Chuanxiong, Rhizoma Kaempferiae, the Radix Angelicae Dahuricae, Herba Asari, Fructus Gleditsia, Borneolum Syntheticum, Radix Cynanchi Paniculati, Herba Centipedae, Flos Magnoliae, Moschus.
The proportioning of described each component is as follows: Rhizoma Chuanxiong 9 parts, Rhizoma Kaempferiae 9 parts, the Radix Angelicae Dahuricae 9 parts, Herba Asari 3 parts, Fructus Gleditsia 9 parts, Borneolum Syntheticum 3 parts, Radix Cynanchi Paniculati 9 parts, Herba Centipedae 9 parts, Flos Magnoliae 9 parts, 3 parts of Moschus.
Described a kind of Chinese medicine powder for treating palsy facial paralysis, its making and using method are for and to pulverize above-mentioned raw materials according to corresponding proportioning mix homogeneously, with gauze powder wrapped up during use and fill in nasal cavity, being sucked by general breathing.
Embodiment 3
A kind of Chinese medicine powder for treating palsy facial paralysis, it comprises following raw material: Rhizoma Chuanxiong, Rhizoma Kaempferiae, the Radix Angelicae Dahuricae, Herba Asari, Fructus Gleditsia, Borneolum Syntheticum, Radix Cynanchi Paniculati, Herba Centipedae, Flos Magnoliae, Moschus.
The proportioning of described each component is as follows: Rhizoma Chuanxiong 6 parts, Rhizoma Kaempferiae 6 parts, the Radix Angelicae Dahuricae 6 parts, Herba Asari 3 parts, Fructus Gleditsia 6 parts, Borneolum Syntheticum 3 parts, Radix Cynanchi Paniculati 6 parts, Herba Centipedae 6 parts, Flos Magnoliae 6 parts, 3 parts of Moschus.
Described a kind of Chinese medicine powder for treating palsy facial paralysis, its making and using method are for and to pulverize above-mentioned raw materials according to corresponding proportioning mix homogeneously, with gauze powder wrapped up during use and fill in nasal cavity, being sucked by general breathing.
By taking the follow-up investigation of medicine of the present invention, choose middle parting paralysis patient 212 people, 20-30 year 15 people, 31-40 year 48 people, 41-50 year 69 people, 51-60 year 66 people, more than 61 14 people. Curing: facial paralysis symptom all disappears, face nerve replys vigor; Effective: facial paralysis symptom partial disappearance or alleviate, face nerve replys part vigor; Invalid: facial paralysis symptom is without alleviating. Therapeutic effect: cure 202 examples, effective 10 examples, invalid 0 example, cure rate 95.28%, effective percentage 100%, therefore may be used
To find out that Chinese medicine composition of the present invention has good effect for middle parting paralysis.
Case:
Fourth, the Five Dragons, Linzhou City Zhen Nan irrigates people from village, man, 48 years old, and long-term alcohol causes face apoplexy to take this Chinese medicine after 10 days, within 5th, cures.
Tan, Xuchang City people from Xuchang County, man, 62 years old, face apoplexy took this Chinese medicine after 20 days, within 7th, cured.
Zhang, man, 42 years old. Main suit: left side facial hemiparalysis two days. Patient washed one's face with cold water after drinking because of night, finds left side paresis, ptosis of labial angle early morning, found that right eye can not close to second day, and on the left of food entrapment between tooth cheek, emergency is gone to a doctor. Pharmaceutical treatment of the present invention is used, further consultation after 12h, it has been found that symptom substantially alleviates to patient. Reuse medicament of the present invention, restore after three days.
Cui, man, 54 years old.Main suit: facial hemiparalysis seven days. At dusk enjoying the cool under the tree sleeping before five days, finding that the corners of the mouth right side is askew next day, leak, emergency is gone to a doctor. Upon examination it is found that this patient's complexion is slightly red, left eyelid can not close, sialorrhea, and the corners of the mouth right side is askew, tooth malalignment, and left side nasolabial fold drops down mistake. Adopt the present embodiment pharmaceutical treatment, fully recover two days later.
Money, man, 37 years old. Main suit: distortion of commissure one week. On the left of patient's private prosecution, face is numb, left basal part of the ear portion pain with distension, tinnitus. Upon examination it is found that there is herpes at the left ear rear portion of patient, be that viral infection causes facial paralysis. After disinfecting after patient's ear, applying the present embodiment medicament at left back half head and face, and coordinate antherpetic Drug therapy, further consultation after a day, facial hemiparalysis symptom is fully recovered. After ear, herpes is without significant change, continues to take medicine, and fully recovers after two weeks.

Claims (3)

1. the Chinese medicine powder being used for treating palsy facial paralysis, it is characterised in that: it comprises following raw material: Rhizoma Chuanxiong, Rhizoma Kaempferiae, the Radix Angelicae Dahuricae, Herba Asari, Fructus Gleditsia, Borneolum Syntheticum, Radix Cynanchi Paniculati, Herba Centipedae, Flos Magnoliae, Moschus.
2. a kind of Chinese medicine powder for treating palsy facial paralysis according to claim 1, it is characterised in that: the proportioning of described each component is as follows: Rhizoma Chuanxiong 6-9 part, Rhizoma Kaempferiae 6-9 part, Radix Angelicae Dahuricae 6-9 part, Herba Asari 2-3 part, Fructus Gleditsia 6-9 part, Borneolum Syntheticum 2-3 part, Radix Cynanchi Paniculati 6-9 part, Herba Centipedae 6-9 part, Flos Magnoliae 6-9 part, Moschus 2-3 part.
3. a kind of Chinese medicine powder for treating palsy facial paralysis according to claim 2, it is characterized in that: described a kind of Chinese medicine powder for treating palsy facial paralysis, its making and using method are for and to pulverize above-mentioned raw materials according to corresponding proportioning mix homogeneously, with gauze powder wrapped up during use and fill in nasal cavity, being sucked by general breathing.
CN201610198559.9A 2016-04-01 2016-04-01 Traditional Chinese medicine powder for treating stroke and facial paralysis Pending CN105663953A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108452000A (en) * 2018-03-28 2018-08-28 王吉泽 A kind of Chinese traditional medicine composition formula of facial paralysis and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
谢震强: "头痛塞鼻散加味临床验证偶得", 《中医杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108452000A (en) * 2018-03-28 2018-08-28 王吉泽 A kind of Chinese traditional medicine composition formula of facial paralysis and preparation method thereof

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