CN105663952A

CN105663952A - Traditional Chinese medicinal composition for treating gastroenteritis of cows and preparation method of traditional Chinese medicinal composition

Info

Publication number: CN105663952A
Application number: CN201610173562.5A
Authority: CN
Inventors: 李佃场
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-03-24
Filing date: 2016-03-24
Publication date: 2016-06-15

Abstract

The invention discloses a traditional Chinese medicinal composition for treating gastroenteritis of cows and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition comprises Ageratum Conyzoides, Fructus Cinnamomi, Mosla Chinensis, Radix Stellariae, Rhizoma Acori Tatarinowii, Nux Pandani Tectorii, Cortex Ilicis Rotundae, Tetracera Sarmentosa, Rhizoma Kaempferiae, Siberian nitraria fruits, Phyllanthus Emblica, Urena Procumbens, Delphinium Candelabrum, Herba Violae Diamantiacae, Fructus Rhamni Leptophyllae, scandent schefflera roots, Zornia Diphylla Pers, Herba Meliloti Suaveolentis, Eriosema Himalaicum, Wikstroemia Canescens, Herba Stephaniae Longae and Herba Cistanches. The traditional Chinese medicinal composition has the advantages that the traditional Chinese medicinal composition can protect gastrointestinal mucous membranes and improved immunity of the cows to some extent when being used for treating the gastroenteritis of the cows and has the advantages of high cure rate, quick action, short treatment course, nonexistence of toxic and side effect and the like.

Description

A kind of pharmaceutical composition for the treatment of ox gastroenteritis and preparation method thereof

Technical field

The present invention relates to field of veterinary, particularly a kind of pharmaceutical composition for the treatment of ox gastroenteritis and preparation method thereof.

Background technology

Ox gastroenteritis refers to the inflammation that gastrointestinal mucosa and deep tissues thereof occur. Mainly because stomach and intestine are subject to due to strong harmful stimulation, many because having eaten the bad forage of quality, as the hay going mouldy, freezing rotten piece root, forage, rotten corn etc.; Poisonous plant, dripping of irritant drugs and eat the forage of pollution by pesticides by mistake, can directly cause mucous membrane to the intestines and stomach, causes gastroenteritis; Because causing Abwehrkraft des Koepers, malnutrition, excessively forced labour or long-distance transport reduce, make conditionity pathogenic bacteria (Escherichia coli, the necrobacillus etc.) virulence in intestines and stomach strengthen and cause gastroenteritis, in addition, abuse of antibiotics, also can cause Biology Barrier of Gastrointestinal Tract disorder, cause suprainfection. Main clinical manifestation is that early stage ight soil is in the pasty state soft, and the grizzly yellowish-white alternate water sample loose stool of ight soil after several days is abnormal sour smelly, later stage ight soil is dark red, stench, anus redness, around by fleece fecal pollution, lassitude, anorexia or absolutely useless, xanthochromia after the first flush of eye conjunctiva, diarrhoea as slurry, ight soil stench and band blood and mucous membrane, thin and weak unable gradually, mouth parched and tongue scorched, shortness of breath, breathe heavily slightly, pulse condition is counted accurately. Young ox anorexia, becomes thin, and happiness is sleeping, the back of a bow symptom such as stand. The young ox of severe infections lactation is finally because of the death of dewatering.

Current methods for the treatment of is as follows: first will remove the cause of disease, intensive care, goes on a hunger strike 1 ~ 2 day, feed to a small amount of soft digestible feed later, though just sick or row's stench is just rare, discharge feces when obstructed, should clear up stomach and intestine, give 300 ~ 400 grams of sodium sulphate (magnesium) caccagogue etc. Substantially emptying when intestinal contents, the stink of excrement not quite and is still suffered from diarrhoea when more than, wants antidiarrheal, for oral administration with 3000 ~ 5000 milliliters of 0.1% potassium permanganate liquids, or uses other antidiarrheal agent. Diminish inflammation, can select antibiotic etc. Intestinal bleeding can give vitamin K. Western medical treatment ox gastroenteritis is to widely apply antibiotic, the chemical synthetic drugs such as Pituamin. Western medicine is for motherland's traditional Chinese medicine, and the medicine that doctor trained in Western medicine is used, generally makes with chemical synthesis process or obtain through refining and form from natural products. The course for the treatment of is longer, and drug residue is larger, and effect is undesirable.

Summary of the invention

Technical problem to be solved by this invention is to be to provide a kind of pharmaceutical composition for the treatment of ox gastroenteritis; pharmaceutical composition of the present invention is in treatment ox gastroenteritis; can protect gastrointestinal mucosa, strengthen to a certain extent the immunity of ox; there is cure rate high; instant effect; treatment short treating period, the advantage such as have no side effect.

In order to realize foregoing invention object, the invention provides a kind of pharmaceutical composition for the treatment of ox gastroenteritis, described pharmaceutical composition comprises following raw medicinal material: Ageratum conyzoides, Gui Ding, grass-leaved sweetflag, thatch screwpine fruit, iron holly bark, asian tetracera root or leaf, Kaempferia galanga, card are close, emblic leafflower fruit, smallpox of ancient India, oneflower larkspur herb, Herba Violae diamantiacae, thinleaf buckthorn fruit, schefflera arboricola, fourth grass in the last of the ten Heavenly stems, Long Stephania Herb and saline cistanche.

In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Ageratum conyzoides 10-20 weight portion, osmanthus fourth 15-35 weight portion, grass-leaved sweetflag 12-26 weight portion, thatch screwpine fruit 14-32 weight portion, iron holly bark 13-27 weight portion, asian tetracera root or leaf 15-35 weight portion, Kaempferia galanga 10-20 weight portion, block close 12-34 weight portion, emblic leafflower fruit 17-26 weight portion, smallpox 11-31 weight portion of ancient India, oneflower larkspur herb 14-28 weight portion, Herba Violae diamantiacae 10-22 weight portion, thinleaf buckthorn fruit 3-5 weight portion, schefflera arboricola 15-25 weight portion, fourth grass in last of the ten Heavenly stems 10-22 weight portion, Long Stephania Herb 14-28 weight portion and saline cistanche 7-14 weight portion.

In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Ageratum conyzoides 15 weight portions, osmanthus fourth 29 weight portions, grass-leaved sweetflag 23 weight portions, thatch screwpine fruit 30 weight portions, iron holly bark 25 weight portions, asian tetracera root or leaf 34 weight portions, Kaempferia galanga 15 weight portions, block close 20 weight portions, emblic leafflower fruit 24 weight portions, smallpox 31 weight portions of ancient India, oneflower larkspur herb 24 weight portions, Herba Violae diamantiacae 12 weight portions, thinleaf buckthorn fruit 4 weight portions, schefflera arboricola 16 weight portions, fourth grass in the last of the ten Heavenly stems 18 weight portions, Long Stephania Herb 25 weight portions and saline cistanche 10 weight portions.

Described pharmaceutical composition also comprises: shepherd's purse ramie, radix stellariae dichotomae, daghestan sweetclover herb, Himalayan Eriosema and canescent wikstroemia.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Ageratum conyzoides 10-20 weight portion, osmanthus fourth 15-35 weight portion, grass-leaved sweetflag 12-26 weight portion, thatch screwpine fruit 14-32 weight portion, iron holly bark 13-27 weight portion, asian tetracera root or leaf 15-35 weight portion, Kaempferia galanga 10-20 weight portion, block close 12-34 weight portion, emblic leafflower fruit 17-26 weight portion, smallpox 11-31 weight portion of ancient India, oneflower larkspur herb 14-28 weight portion, Herba Violae diamantiacae 10-22 weight portion, thinleaf buckthorn fruit 3-5 weight portion, schefflera arboricola 15-25 weight portion, fourth grass in last of the ten Heavenly stems 10-22 weight portion, Long Stephania Herb 14-28 weight portion, saline cistanche 7-14 weight portion, shepherd's purse ramie 10-20 weight portion, radix stellariae dichotomae 13-31 weight portion, daghestan sweetclover herb 15-24 weight portion, Himalayan Eriosema 9-18 weight portion and canescent wikstroemia 2-4 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Ageratum conyzoides 15 weight portions, osmanthus fourth 29 weight portions, grass-leaved sweetflag 23 weight portions, thatch screwpine fruit 30 weight portions, iron holly bark 25 weight portions, asian tetracera root or leaf 34 weight portions, Kaempferia galanga 15 weight portions, block close 20 weight portions, emblic leafflower fruit 24 weight portions, smallpox 31 weight portions of ancient India, oneflower larkspur herb 24 weight portions, Herba Violae diamantiacae 12 weight portions, thinleaf buckthorn fruit 4 weight portions, schefflera arboricola 16 weight portions, fourth grass in the last of the ten Heavenly stems 18 weight portions, Long Stephania Herb 25 weight portions, saline cistanche 10 weight portions, shepherd's purse ramie 14 weight portions, radix stellariae dichotomae 28 weight portions, daghestan sweetclover herb 22 weight portions, Himalayan Eriosema 14 weight portions and canescent wikstroemia 3 weight portions.

The formulation of described pharmaceutical composition is powder-injection, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into micronizer and be ground into the mixed powder that the micron particles of 0.1～10 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, described mixed powder powder rate be at least 95%;

Second step, the ethanol that to add with respect to the determining alcohol of 3～5 times of the quality of described mixed powder in the mixed powder obtaining in the first step be 85%～95%, stirring and dissolving obtains ethanolic solution, ethanolic solution is left standstill to 24～36 hours under the condition of 5 DEG C～10 DEG C, adopt the speed slowly diacolation of percolation with 1～2ml per minute, collect percolate, concentrate and be dried, and put into micronizer at this and pulverize 40～60 minutes, the micron particles of acquisition 0.1～10 μ m volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets mixed powder 10g～20g that second step obtains, and adds propane diols 30g～50g, adds 200ml water for injection, stirs it is dissolved, and further injects water to 1000ml, then adds 1g～1.5g needle-use activated carbon, fully stirs 30～50 minutes; Decarbonization filtering; With 0.22～0.24 μ m filtering with microporous membrane; Freeze drying obtains aseptic powdery, packing embedding.

The formulation of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

The first step, thatch screwpine fruit, iron holly bark, asian tetracera root or leaf, Kaempferia galanga and Ka Mi are mixed in described ratio, and the ethanol that to use with respect to the determining alcohol of 3～5 times of mixture quality obtaining be 85%～95% dissolves, and adds hot reflux and extracts after 2～4 hours, filter, obtain the first filtered fluid; Filter residue is used to the ethanol dissolving with respect to the determining alcohol 85%～95% of 1～2 times of the mixture quality obtaining again, add hot reflux and extract after 1～2 hour, filter, obtain the second filtered fluid; Merge the first filtered fluid and the second filtered fluid, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, the large pore resin absorption column wash-out that is 5L through volume, first use deionized water or the distilled water wash-out of 5 times of resin column volumes, be 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol eluate, reduced pressure concentration is removed ethanol, is dried and is ground into powder;

Second step, schefflera arboricola, fourth grass in the last of the ten Heavenly stems, Long Stephania Herb and saline cistanche are mixed in described ratio, add the ethanol with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtaining, heating and refluxing extraction 1～2 time, extract merges, with the centrifugal removal of impurities of tube centrifuge, the lotion that when extract after removal of impurities is evaporated to 60 DEG C under the condition of 60 DEG C～70 DEG C, relative density is 1.20～1.23, is dried to powder by the lotion after concentrated with spray dryer;

The 3rd step, mixes surplus stock medicinal material in described ratio, add the water-soluble solution of 2～4 times with respect to the mixture quality obtaining, and heating decocts 2～4 hours, filters; Filter residue is used to the water-soluble solution of 1～2 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour again, filters; Merge the filtered fluid of twice, reduced pressure concentration is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and is screened into subsequently 80～120 object fine powders, and the fine powder of acquisition is dropped in mixing and blending machine and stirred, and obtains powder.

The invention has the beneficial effects as follows: pharmaceutical composition of the present invention, in treatment ox gastroenteritis, can be protected gastrointestinal mucosa, strengthen to a certain extent the immunity of ox, has cure rate high, instant effect, treatment short treating period, the advantage such as have no side effect.

Detailed description of the invention

The invention provides a kind of pharmaceutical composition for the treatment of ox gastroenteritis, comprise following raw medicinal material: Ageratum conyzoides, Gui Ding, shepherd's purse ramie, radix stellariae dichotomae, grass-leaved sweetflag, thatch screwpine fruit, iron holly bark, asian tetracera root or leaf, Kaempferia galanga, card are close, emblic leafflower fruit, smallpox of ancient India, oneflower larkspur herb, Herba Violae diamantiacae, thinleaf buckthorn fruit, schefflera arboricola, fourth grass in the last of the ten Heavenly stems, daghestan sweetclover herb, Himalayan Eriosema, canescent wikstroemia, Long Stephania Herb and saline cistanche.

The pharmacological property of above-mentioned each raw medicinal material is as follows:

Saline cistanche: nature and flavor: sweet, salty, temperature. Gui Jing: return kidney, large intestine channel. Cure mainly: kidney-replenishing, benefiting essence-blood, relaxes bowel. For impotence, infertile, soreness and weakness of waist and knees, muscles and bones is unable, the dry constipation of intestines. Saline cistanche Himalayan Eriosema: another name: the short top top of heart, napiform root hair hemp nettle. Source: pulse family hair hemp nettle platymiscium Himalayan Eriosema EriosemahimalaicumOhashi[E.tuberosum(Buch.-Ham.) WangetTang], be used as medicine with piece root. Adopt autumn, cleans section, dries. Nature and flavor: sweet, bitter, puckery, flat. Cure mainly: stomach invigorating disappears long-pending regulating qi-flowing for relieving pain. For infantile malnutrition, indigestion, stomach abdomen pain, diarrhoea, traumatic injury.

Fourth grass in the last of the ten Heavenly stems: another name: RENZICAO, two leaf RENZICAOs, the fly wing, the black fly wing, PUDIJIN [Guangdong], lao-ya-tsao, golden mandarin duck. Source: be pulse family fourth grass in last of the ten Heavenly stems platymiscium fourth grass in last of the ten Heavenly stems Zorniadiphylla(L.) Pers., with all herbal medicine. Summer, autumn gather. Nature and flavor: sweet, light, cool. Cure mainly: clearing heat and detoxicating, removing pattogenic heat from the blood and toxic material from the body. For flu, sphagitis, acute icteric hepatitis, acute gastroenteritis, acute appendicitis, infantile malnutrition, acute mastitis, eye keratitis; Traumatic injury is controlled in external application, carbuncle furuncle poison, venomous snake bite.

Schefflera arboricola: source: Guangzhou army " conventional Chinese herbal medicine handbook ". Another name: leaflet Ivy Tree Bark, CAULIS SCHEFFLERAE KWANGSIENSIS (" Guangxi Chinese herbal medicine "), hand tree, seven adds skin, seven leaf mushrooms (" the practical Chinese herbal medicine in Guangxi newly selects "), seven leaves rotten (Guangzhou army " conventional Chinese herbal medicine "). Source: be root or the cauline leaf of Araliaceae schefflera arboricola. Can adopt the whole year. Clean, dry. Nature and flavor: micro-hardship, temperature. 1. " Guangxi Chinese herbal medicine ": " warm in nature, taste is pungent. " 2. Guangzhou army " conventional Chinese herbal medicine handbook ": " is bitter sweet, temperature. " cure mainly: dispel rheumatism, promoting blood circulation and stopping pain. Control arthralgia due to wind-dampness, stomachache, injury and bone fracture, traumatism and bleeding. " the practical Chinese herbal medicine in Guangxi newly selects ": " promoting qi circulation and relieving pain, activating blood circulation and reducing swelling strengthen the bone. Control acute rheumatic arthritis, stomachache, fracture, bruise, pain in waist and lower extremities, paralysis. "

Thinleaf buckthorn fruit: [source] " Chongqing herbal medicine ". [another name] son (" classification herbal medicine ") of shooting, be pear (" conventional glossary of Herbs and Drugs among the people "), be ear mothers and sons, be bell (" Traditional Chinese Medicine in Sichuan will "), money, thunder-crash bomb, Lei Zhenzi (" Chongqing herbal medicine "), dateplum persimmon (Chengdu " conventional herbtherapy handbook "). [nature and flavor] " Kweiyang medicinal herbs among the people ": " hardship, cold, poisonous. " [function cures mainly] helps digestion, row water, defaecation. Control dyspepsia glutted, oedema tympanites, constipation. 1. " conventional glossary of Herbs and Drugs among the people ": " help digestion, remove to amass Li Shui. " 2. " Kweiyang medicinal herbs among the people ": " relieve oedema or abdominal distension through diuresis or purgation, detumescence, defaecation. Control dyspepsia, tympanites, constipation. " thinleaf buckthorn fruit oneflower larkspur herb: source: " the sweet peaceful blue or green Chinese herbal medicine choosing in Shan ". Another name: moral wood Sa (hiding name). Source: be the herb of ranunculaceae plant oneflower larkspur herb. Gather summer, washes away silt, removes residual stem on root, withered skin, dries. Nature and flavor: warm in nature. Cure mainly: Wen Zhong, antidiarrheal. Control stomach and intestine crymodynia, have loose bowels.

Smallpox of ancient India: source: come from " Fujian traditional herbal medicine ". Another name: trident maple, three closes that maple, Hong Kong Anemone Vitifolia, dog fall mark, dog fall pawl, wild eggplant, rag strangle, false meat is colored, the numb head of lice, the Five Dragons meeting, sticky colorful clothes, false cotton, cotton, eight sledgehammers, the dry mallet that snows, little peach blossom, a little mother-in-law of being crazy about, berchemia lineata, black clouds lid, Anemone Vitifolia, RADIX ANEMONAE, cotton kidney, red Anemone Vitifolia, small size mountain cotton skin, wild kapok, road blocking tiger, cochinchina leafflower herb. Source: medicinal material Ji Yuan: be the herb of Malvaceae plant smallpox of ancient India. Latin plant animal mineral name: UrenaprocumbensL.[U.sinuataL.]. Gather and store: excavate herb in summer, autumn, clean, remove impurity, chopping, dries. Nature and flavor: sweet; Bitter; Cool in nature. Gui Jing: liver; Large intestine channel. Cure mainly: expelling wind and removing dampness; Heat reliving and toxin-eliminating. Main air pain of dampness syndrome; Have loose bowels; Dysentery; Flu; Abscess of throat; Cough with lung heat; Wind poison streamer; Sore swollen toxin; Traumatic injury; Venomous snake bite.

Thatch screwpine fruit: source: come from Compendium of Material Medica. " Gui Haiyu weigh will ": thatch screwpine fruit, large as half liter of bowl, examines closely it, and balling-up is gathered closely together in tens of rooms, and every room is seamed, and the winter is raw blue or green, red to the summer, its lobe food micro-sweet. Another name: reveal pocket, Jin POLO, false pineapple, mountain POLO, strangle silver coin, mother-in-law saw and strangle son, wild pineapple. Source: medicinal material Ji Yuan: be the drupe of Pandanaceae plant aggag. Nature and flavor: taste is pungent; Light; Cool in nature. Gui Jing: kidney; Spleen; Liver; Stomach warp. Cure mainly: tonifying spleen benefit blood; Promoting qi circulation and relieving pain; Dampness removing reduces phlegm; Improving eyesight. Main dysentery; Stomachache; Cough; Hernia; Orchitis; Hemorrhoid difficult urination; The raw ocular of order.

Radix stellariae dichotomae: source: " detailed outline ". Another name: Yin Hu (" book on Chinese herbal medicine is looked for the truth "), mountain dish root, mountain horse step on dish root (" Shandong Chinese medicine "), tripe root, the root of straight ladybell, white root, soil ginseng (" Chinese medicinal herbal "). Source: be the root of pinkwort radix stellariae dichotomae. Excavate autumn, removes stem, leaf and fibrous root, cleans, and dries. Nature and flavor: sweetness and bitterness, cool. Gui Jing: enter liver, stomach warp. Cure mainly: clearing heat and cooling blood. Control consumptive disease hectic fever due to yin, deficiency of Yin chronic malaria, children's's infantile malnutrition due to digestive disturbances or intestinalparasites heat is thin thin. " it is former that book on Chinese herbal medicine is asked ": " clearing lung-heat, stomach, spleen, kidney heat, holding concurrently can cool blood. Treating disorders in five ZANG-organs is deficient, skin labor heat, the tired pain of hectic fever due to yin, arthritis with fixed pain caused by dampness contraction. "

Kaempferia galanga: source: " detailed outline ". Another name: three sons (" sea side ") how, three rely (" product converge smart will "), three a kind of apples, mountain peppery (" detailed outline ") ， tri-Lai (" South Uietnam notes "), husky ginger (" south of the Five Ridges gather medicinal herbs record "). Source: be the rhizome of zingiberaceous plant Kaempferia galanga. Between March December to next year, when the aerial stem of plant withers, take biennial rhizome, wash away earth, crosscut is in blocks. , after 1 day, be layered on bamboo mat and dry with Sulfur sootiness. Must guard against fire and dry, otherwise become black, lack fragrance. Nature and flavor: pungent, temperature. 1. " product remittance essence is wanted ": " taste is pungent, warm in nature, nontoxic. " 2. " book on Chinese herbal medicine converges and says ": " acrid-sweet flavor, warm in nature, nontoxic. " return through: enter stomach warp. 1. " book on Chinese herbal medicine converges and says ": " enter bright, the large the moon of foot sun, JUE YIN meridian. " 2. " book on Chinese herbal medicine is new again ": " enters the heart, spleen, kidney three warps. " cure mainly: Wen Zhong, help digestion, pain relieving. Control trusted subordinate's crymodynia, stop dyspepsia, traumatic injury, toothache. For septum pectorale turgor, coldness and pain in the epigastrium. Diet does not disappear.

Iron holly bark: another name: silver bark, ninebark, white orchid perfume (or spice), bear gall wood. Source: the bark (double-layer fur) of Aquifoliaceae Holly ilexrotunda IlexrotundaThunb., leaf, root also can be used as medicine. Can adopt the whole year, scrapes off outer tertia, and chopping, dries or using fresh herb; Leaf mostly is using fresh herb, and root is excavated spring and autumn. Nature and flavor: hardship, cool. Cure mainly: clearing heat and detoxicating, swelling and pain relieving. For flu, tonsillitis, abscess of throat, acute gastroenteritis, treating rheumatic ostealgia; Traumatic injury is controlled in external application, carbuncle furuncle sore, traumatism and bleeding, burn and scald.

Canescent wikstroemia: source: " herbal classic ". Source: be the flower of Isolated From Thymelaeaceae Species canescent wikstroemia. Nature and flavor: arduous, cold, poisonous. 1. " herbal classic ": " bitter, cold. " 2. " not Lu ": " is pungent, is slightly cold, poisonous. " return through: " book on Chinese herbal medicine is looked for the truth ": " enters stomach. " cure mainly: water pouring drink, broken gathering. Control and stay drink, cough with dyspnea, oedema, abdominal mass Xuan addiction. 1. " herbal classic ": " main typhoid fever a kind of malaria, lower 12 water brokenly gather, large hard abdominal mass, cleanse in stomach and stay addiction, diet, fever and chills perverse trend, dredging water passages. " 2. " not Lu ": " treats phlegmatic cough. " 3. " property of medicine opinion ": " controls cough with dyspnea, turgor in larynx, Xuan addiction air parcel, lower oedema etc. "

Gui Ding: source: " detailed outline is picked up any lost article from the road ". Another name: FRUCTUS CINNAMOMI CASSIAE LMMA-TURI (" hundred careless mirrors "), Gui Zi (" Chinese medicinal herbal "), osmanthus cloves (" Shanghai process of preparing specification "). Source: be the tender fruit of children of canella Chinese cassia tree. Pluck immature fruit branch 10～November, remove branch, dry. Nature and flavor: Xin Gan, temperature. Cure mainly: " Chinese medicinal herbal ": " warming spleen and stomach for dispelling cold is controlled the cold mediocre sound of vomiting of vomitting of gastral cavilty. "

Long Stephania Herb: source: " south of the Five Ridges gather medicinal herbs record ". Another name: Ha Soft-Fleece grass, frog grass (" south of the Five Ridges gather medicinal herbs record ") ， Lei Portland mouth, dustpan grass, the Thunder God (" Nanning City's medicine will ") that flies to the sky, mouldboard rattan, iron plate plaster grass (Fujian). Source: be herb or rhizome and the root of menispermaceous plants Long Stephania Herb. Can adopt the whole year. Generally how to extract in the fall rattan leaf or to grub out and get, washing away silt particle, removing radicula, drying or using fresh herb. Nature and flavor: 1. " south of the Five Ridges gather medicinal herbs record ": " taste raw meat, property is flat. " 2. " Luchuan book on Chinese herbal medicine ": " hardship, cold. " cure mainly: clearing heat and detoxicating, dampness removing defaecation, the sore that disappears is swollen. Control pyreticosis and go mad, jaundice, gastroenteritis, dysentery, constipation, hematuria, sore and toxic. 1. " south of the Five Ridges gather medicinal herbs record ": " promote tissue regeneration and stop bleeding. Control dysentery, control again jaundice, go mad. Breast sore, and piece candy mash apply it. " 2. " Luchuan book on Chinese herbal medicine ": " refreshing and detoxicating, logical stool. Control enterogastritis, constipation; Snake bite. " 3. " Nanning City's medicine will ": " clearing away heat and promoting diuresis, controls inflammatory diarrhea and hematuria; Sore is disliked in external application, detumescence poison. "

Block close: source: " Deserts in China area medicinal plant ". Another name: Nitraria sibirica (" Deserts in China area medicinal plant "), acid is fat, breathe out not (" Inner Mongol Chinese herbal medicine "). Source: be the fruit of the white thorn of zygophyllaceae plant fruitlet. When fruit is ripe, gather, dry. Nature and flavor: sweet acid is micro-salty, temperature. Cure mainly: strengthening the spleen and stomach, strengthening by means of tonics, regulating menstruation and activating blood. Control gynecological ailments, qi-blood deficiency, incoordination between the spleen and the stomach, indigestion, irregular menstruation, waist abdomen pain.

Shepherd's purse ramie: source: Tang Materia Medica. Another name: smelly Soviet Union, bluish white Soviet Union (" Japan hanako materia medica "). Source: be stem, the leaf of labiate shepherd's purse ramie. Summer, autumn gather. Nature and flavor: " detailed outline ": " pungent, temperature, nontoxic. " return through: " book on Chinese herbal medicine converge with speech ": " starts with, sufficient Yangming Channel. " curing mainly: 1. supplement to the Herbal: ", except ant fistula, Re is broken applies it. Also main cold air is let out dysentery; Can be romaine lettuce, except sour water between stomach. "

Grass-leaved sweetflag: another name: grassleaf sweetflag leaf, mountain calamus, water sword grass, white flag, medicine calamus. Source: this product is the dry rhizome of acorus gramineus araceae plant AcorustatarinowiiSchott. Autumn, two seasons of winter excavate, and remove fibrous root and silt, dry. Nature and flavor: pungent, bitter, temperature. Gui Jing: the thoughts of returning home, stomach warp. Cure mainly: dampness elimination appetizing, the open-minded phlegm of having one's ideas straightened out, inducing resuscitation intelligence development. Not hungry for gastral cavity ruffian, mouthful diarrhea of keeping silent, coma epilepsy, forgetful deafness.

Ageratum conyzoides: another name: halfspreading ironweed herb, Pemisetum flaccidum Griseb, spend vanilla in vain, spend stinkweed in vain, lemon chrysanthemum, seven-star chrysanthemum, white hair hardship, cat dung grass, purulence bubble are careless, win red medicine, anti-inflammatory grass. Source: composite family Ageratum plant Ageratum conyzoides AgeratumconyzoidesL., is used as medicine with herb or leaf and tender stem. Xia Qiu gathers, and cleans using fresh herb or dry. Nature and flavor: pungent, micro-hardship, cool. Cure mainly: expelling wind and clearing away heat, pain relieving, hemostasis, row's stone. For the infection of the upper respiratory tract, tonsillitis, sphagitis, acute gastroenteritis, stomachache, stomachache, uterine bleeding, kidney stone, vesical calculus; Eczema is controlled in external application, thrush, carbuncle pyogenic infections from tumour or sore, cellulitis, the ulcer of lower limb, tympanitis, traumatism and bleeding.

Scabrous Mosla Herb: source: supplement to the Herbal. Source: be the herb of the coarse shepherd's purse ramie of labiate. Take herb 7～August, dry. Nature and flavor: arduous, cool. Supplement to the Herbal: " pungent, temperature, nontoxic. " cure mainly: clear hot summer weather, wines used as antirheumatic, detumescence, removing toxic substances. Control hot summer weather acute filthy disease, bleeding from five sense organs or subcutaneous tissue, bloody flux, cold cough, chronic bronchitis, ulcer sore is swollen, rubella, hot miliaria.

Emblic leafflower fruit: source: Tang Materia Medica. Another name: emblic (" foreign matter will borders on the sea "), emblic (Tang Materia Medica), the Buddhist nunnery character used in proper names and in rendering some foreign names fruit (" detailed outline ") that rubs, hope fruit (" Chinese tree systematics "), Phyllanthus embical fruit (" Guangzhou flora "), Niu Ganzi (" Nanning City's medicine spring "), olive is pulled son (" Traditional Chinese Medicine in Sichuan will "), pyhllanth usemhlica L., barna fruit (" Guangxi medicine is planted register "), Yunnan olive (" choosing of Yunnan Chinese herbal medicine "). Source: be the fruit of euphorbia plant phyllanthus emblica. Gather when fruit is ripe for 9～October, dries. Nature and flavor: bitter sweet, cold. 1. Tang Materia Medica: " bitter but sweet flavor, cold, nontoxic. " 2. " Haiyao Bencao, Oversea Materia Medica ": " bitter acid is sweet, is slightly cold, nontoxic. " return through: " Traditional Chinese Medicine in Sichuan will ": " enters spleen, stomach two warps. " cure mainly: reduce phlegm, promote the production of body fluid, cough-relieving, removing toxic substances. The heating that cures cold, cough pharyngalgia, diphtheria, restlessness and fever with thirst. 1. Tang Materia Medica: " main air abnormal heat gas. " 2. supplement to the Herbal: " main help, strong strength. Get son pressure and get juice and oily coating head hair tonic, go pruritus, rendering is sent out de-, and rear life is as paint. The cough of " 3. " Haiyao Bencao, Oversea Materia Medica ": " Your Majesty's gas. " 4. " Nanning City's medicine will ": " refreshing and detoxicating, controls larynx numbness. " 5. Guangzhou army " conventional Chinese herbal medicine handbook ": " moistening lung for removing phlegm, promotes the production of body fluid to quench thirst. "

Daghestan sweetclover herb: source: " Illustrated Book on Plants ". Another name: wild alfalfa, Pin Chuan bush clover, Fu bush clover (" Chinese main plant figure says pulse family "), TIESAOBA (" Traditional Chinese Medicine in Sichuan will "), clarke boea herb (" medicine investigation is planted in Shaanxi "), Ocimum basilicum L. var. pilosum, wild peanut, chicken head flowers and plants (" Chinese herbal medicine is commonly used in Shanghai "), chicken lousewort (" Chinese herbal medicine is commonly used in Sichuan "), sweet vernal grass sweet-scented osmanthus (" Jilin Chinese herbal medicine "), smelly clover, the grass that relieves internal heat (" Shaanxi Chinese herbal medicine "), fragrant horse material (" discriminating of Heilongjiang Province Main Wild Medicinal plant and Chinese herbal medicine novel formulation "), in very stop in east (towards name). Source: be the herb of legume sweet clover. Florescence harvesting herb, dries in the shade. Nature and flavor: arduous, cool. 1. " Traditional Chinese Medicine in Sichuan will ": " bitter light, cool, nontoxic. " 2. " Chinese herbal medicine is commonly used in Shanghai ": " is pungent, flat. " cure mainly: heat-clearing, removing toxic substances, dampness elimination, desinsection. Control hot summer weather uncomfortable in chest, malaria, dysentery, gonorrhoea, skin ulcer. 1. " Traditional Chinese Medicine in Sichuan will ": " heat-clearing, removing toxic substances, desinsection, diuresis. Control skin sore, wind pellet, dysentery, gonorrhoea. " 2. " Chinese herbal medicine is commonly used in Shanghai ": " and in, stomach invigorating, dampness elimination. Control summer-heat and damp uncomfortable in chest, mouth is greasy, halitosis, alliteration. Headache. Poison is dared in " 3. " Shaanxi Chinese herbal medicine ": " heat-clearing, only dysentery, preventing malaria, stomach invigorating, dampness elimination. Control dysentery, malaria, halitosis, headache. "

Asian tetracera root or leaf: source: Guangzhou army " conventional Chinese herbal medicine handbook ". Another name: Xi Ye (" south of the Five Ridges gather medicinal herbs record "), puckery rattan, puckery husky rattan (" Luchuan book on Chinese herbal medicine "), puckery leaf rattan (" Hainan flora "), large puckery sand, Shibuya rattan (" Guangxi medicine is planted register "), waterwheel rattan (Guangzhou army " commonly using Chinese herbal medicine handbook "). Source: be root or the leaf of Dilleniaceae plant asian tetracera root or leaf. Nature and flavor: " Luchuan book on Chinese herbal medicine ": " cool in nature, bitter and puckery flavor. " cure mainly: control enteritis, dysentery, prolapse of the anus, seminal emission, falls and beats. 1. " south of the Five Ridges gather medicinal herbs record ": " leaf: control red dysentery characterized by white mucous stool. " 2. " Luchuan book on Chinese herbal medicine ": " leaf: antidiarrheal hemostasis, promoting granulation and wound healing. Control diarrhoea, stain ulcer. " 3. " Guangxi medicine is planted register ": " root: control prolapse of the anus, metroptosis, protracted dysentery, seminal emission, falls and beats. " 4. Guangzhou army " conventional Chinese herbal medicine handbook ": " convergence, antidiarrheal, controlling nocturnal emission with astringent drugs. Control enteritis, diarrhea, hepatosplenomegaly, seminal emission. "

Herba Violae diamantiacae: another name: large whiteflower violet herb with root, great Ye violet. Source: for Violaceae Viola plant great Ye violet VioladiamantiacaNakai, with all herbal medicine. Gather late summer, cleans, and dries. Nature and flavor: pungent, bitter, cool. Cure mainly: clearing heat and detoxicating, hemostasis. For sore furuncle poison, sty, venomous snake bite, traumatism and bleeding.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 pharmaceutical composition 1

The embodiment of the present invention provides a kind of pharmaceutical composition for the treatment of ox gastroenteritis, is made up of the raw medicinal material of following parts by weight: Ageratum conyzoides 15 weight portions, Gui Ding 29 weight portions, grass-leaved sweetflag 23 weight portions, thatch screwpine fruit 30 weight portions, iron holly bark 25 weight portions, asian tetracera root or leaf 34 weight portions, Kaempferia galanga 15 weight portions, block close 20 weight portions, emblic leafflower fruit 24 weight portions, smallpox of ancient India 31 weight portions, oneflower larkspur herb 24 weight portions, Herba Violae diamantiacae 12 weight portions, thinleaf buckthorn fruit 4 weight portions, schefflera arboricola 16 weight portions, fourth grass in the last of the ten Heavenly stems 18 weight portions, Long Stephania Herb 25 weight portions and saline cistanche 10 weight portions.

The first step, described raw medicinal material is mixed in proportion, put into micronizer and be ground into the mixed powder that the micron particles of 3 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, described mixed powder powder rate be at least 95%;

Second step, the ethanol that to add with respect to the determining alcohol of 4 times of the quality of described mixed powder in the mixed powder obtaining in the first step be 90%, stirring and dissolving obtains ethanolic solution, ethanolic solution is left standstill to 30 hours under the condition of 9 DEG C, adopt the speed slowly diacolation of percolation with 2ml per minute, collect percolate, concentrate and be dried, and put into micronizer at this and pulverize 50 minutes, obtain the mixed powder that the micron particles of 4 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets the mixed powder 15g that second step obtains, and adds propane diols 40g, adds 200ml water for injection, stirs it is dissolved, and further injects water to 1000ml, then adds 1.5g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μ m filtering with microporous membrane; Freeze drying obtains aseptic powdery, packing embedding.

Embodiment 2 pharmaceutical compositions 2

The embodiment of the present invention provides a kind of pharmaceutical composition for the treatment of ox gastroenteritis, raw medicinal material by following parts by weight is made: Ageratum conyzoides 15 weight portions, osmanthus fourth 29 weight portions, grass-leaved sweetflag 23 weight portions, thatch screwpine fruit 30 weight portions, iron holly bark 25 weight portions, asian tetracera root or leaf 34 weight portions, Kaempferia galanga 15 weight portions, block close 20 weight portions, emblic leafflower fruit 24 weight portions, smallpox 31 weight portions of ancient India, oneflower larkspur herb 24 weight portions, Herba Violae diamantiacae 12 weight portions, thinleaf buckthorn fruit 4 weight portions, schefflera arboricola 16 weight portions, fourth grass in the last of the ten Heavenly stems 18 weight portions, Long Stephania Herb 25 weight portions, saline cistanche 10 weight portions, shepherd's purse ramie 14 weight portions, radix stellariae dichotomae 28 weight portions, daghestan sweetclover herb 22 weight portions, Himalayan Eriosema 14 weight portions and canescent wikstroemia 3 weight portions.

The first step, mixes thatch screwpine fruit, iron holly bark, asian tetracera root or leaf, Kaempferia galanga and Ka Mi in described ratio, the ethanol that to use with respect to the determining alcohol of 4 times of mixture quality obtaining be 90% dissolves, and adds hot reflux and extracts after 3 hours, and filtration, obtains the first filtered fluid; Filter residue is used to the ethanol dissolving with respect to the determining alcohol 90% of 2 times of the mixture quality obtaining again, add hot reflux and extract after 2 hours, filter, obtain the second filtered fluid; Merge the first filtered fluid and the second filtered fluid, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, the large pore resin absorption column wash-out that is 5L through volume, first use deionized water or the distilled water wash-out of 5 times of resin column volumes, be 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol eluate, reduced pressure concentration is removed ethanol, is dried and is ground into powder;

Second step, schefflera arboricola, fourth grass in the last of the ten Heavenly stems, Long Stephania Herb and saline cistanche are mixed in described ratio, add the ethanol with respect to the determining alcohol 90% of 3 times of the mixture quality obtaining, heating and refluxing extraction 2 times, extract merges, with the centrifugal removal of impurities of tube centrifuge, the lotion that when extract after removal of impurities is evaporated to 60 DEG C under the condition of 65 DEG C, relative density is 1.22, the lotion after concentrated is dried to powder with spray dryer;

The 3rd step, mixes surplus stock medicinal material in described ratio, add the water-soluble solution of 3 times with respect to the mixture quality obtaining, and heating decocts 3 hours, filters; Filter residue is used to the water-soluble solution of 1.5 times with respect to the mixture quality obtaining again, and heating decocts 1.5 hours again, filters; Merge the filtered fluid of twice, reduced pressure concentration is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and is screened into subsequently 100 object fine powders, and the fine powder of acquisition is dropped in mixing and blending machine and stirred, and obtains powder.

The toxicity test of pharmaceutical composition:

1, trial drug

Choose Ageratum conyzoides 15g, Gui Ding 29g, grass-leaved sweetflag 23g, thatch screwpine fruit 30g, iron holly bark 25g, asian tetracera root or leaf 34g, Kaempferia galanga 15g, block close 20g, emblic leafflower fruit 24g, smallpox 31g of ancient India, oneflower larkspur herb 24g, Herba Violae diamantiacae 12g, thinleaf buckthorn fruit 4g, schefflera arboricola 16g, fourth grass 18g, Long Stephania Herb 25g in the last of the ten Heavenly stems and saline cistanche 10g mix, and is ground into powder; Acquisition powder is added in 1400g cold water and soaked 25 hours, and with slow fire boiling, decocting time is 1.5 hours, and decoction liquor is filtered, and obtains the first filtrate, collects filter residue; Again add in 1400g cold water filtering the filter residue obtaining, with slow fire boiling 3 times, decoct 1 hour at every turn, filter and merge filtered fluid, obtain the second filtrate; Merge filtrate twice, reduced pressure concentration remove portion water, obtains decoction, and the crude drug concentration of decoction is 3g/ml.

2, test method: select SD rat, give the decoction of the pharmaceutical composition of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, after last administration, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half), and all the other 1/2 animals continue observation and live and kill after 2 weeks. Duration of test is observed outward appearance, general behavior, food ration, the changes of weight of animal, and after administration, the index checkings such as hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, Histopathology are carried out in 90 days and drug withdrawal for 2 weeks. Result of the test shows: pharmaceutical composition of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Three dosage groups and control group hematological examination, blood biochemical are learned, urine biochemical analysis is all in normal range (NR), between group without significant difference; Each group main organs histopathological examination shows no obvious abnormalities. These parameters drug withdrawal also has no change after 2 weeks. This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test pharmaceutical composition of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, points out the dosage safety of pharmaceutical composition clinical practice of the present invention higher.

Contrast test

Inner Mongol Ba Bainiu plant, in by the end of December, 2013, finds the ox of 300 1.5 years old mean aves nearly, and ight soil is in the pasty state soft at the initial stage of a disease, the grizzly yellowish-white alternate water sample loose stool of ight soil after several days, abnormal sour smelly, later stage ight soil is dark red, stench, anus redness, around by fleece fecal pollution, lassitude, anorexia, xanthochromia after the first flush of eye conjunctiva, diarrhoea as slurry, ight soil stench and band blood and mucous membrane, thin and weak unable gradually, mouth parched and tongue scorched, shortness of breath, breathes heavily slightly, and pulse condition such as counts accurately at the symptom.

From above-mentioned 300 oxen, choose 180,180 oxen are divided into three groups at random, be respectively 1 group of embodiment, 2 groups of embodiment and control group, the ill ox of three groups all without significant difference, has comparativity at the aspect such as body weight, the state of an illness. 1 group of embodiment, 2 groups of embodiment and control group use respectively the powder-injection of the embodiment of the present invention 1, powder and the conventional medicament of embodiment 2 to treat; Wherein, powder-injection adopts hypodermic injection, and each 60mg/kg, every day twice, injects 6 days continuously; The using method of powder be by powder according in the part by weight conventional feed of 7g:500g, feed continuously 6 days; Conventional medicament first gives 300g sodium sulphate, and substantially emptying when intestinal contents, the stink of excrement not quite and is still suffered from diarrhoea when more than, wants antidiarrheal, more for oral administration with 4000 milliliters of 0.1% potassium permanganate liquids, and continuous 6 days, the conventional feed of feeding. Be 6 days experimental period, before and after experiment, takes respectively each group of ill ox body weight, records during this time recovery from illness situation and the death toll of ill ox, calculate cure rate, average daily ingestion amount and average body condition divide (BCS), and cure the time comparison of number, and result is as shown in table 1, table 2 and table 3. Wherein, cure: stool colour is normal, and mental restoration is normal, appetite increases, and eye conjunctiva recovers normal, mouth parched and tongue scorched, and shortness of breath, breathes heavily slightly, and it is normal that pulse condition such as counts accurately at the glucose recovery; Invalid: clinical symptoms are not improved.

The result for the treatment of table of comparisons of the each experimental group ox of table 1

Group	Sum	Recovery from illness number	Invalid number	Cure rate
					1 group of embodiment	60	60	0	100%
2 groups of embodiment	60	60	0	100%
					Control group	60	48	12	80%

Data from table 1: compared with conventional medicament, the pharmaceutical composition of the embodiment of the present invention 1 and 2 has advantage evident in efficacy, cheap, that have no side effect aspect treatment ox gastroenteritis.

Known by contrast test: compared with conventional medicament; the pharmaceutical composition of the embodiment of the present invention 1 and 2 has toxic and side effect advantage little, evident in efficacy aspect treatment ox gastroenteritis; can protect gastrointestinal mucosa, strengthen to a certain extent the immunity of ox, but also can be good at ensureing the normal growth of other organs of ox.

In the each experimental group of table 2, the average lactation amount of every ox, average daily ingestion amount and average body condition divide the result for the treatment of table of comparisons of (BCS)

Group	Average daily ingestion amount (kg/d)	Average body condition divides (BCS)
			1 group of embodiment	28.6±0.4	2.8±0.25
2 groups of embodiment	31.9±0.4	3.2±0.25
			Control group	26.7±0.4	1.6±0.25

The average daily ingestion amount that 1 group of data from table 2: embodiment and embodiment are 2 groups all has growth than control group, has improved 1.9kg/d, 5.2kg/d. The average body condition that 1 group of embodiment and embodiment are 2 groups divides (BCS) to make moderate progress with respect to control group.

Known by contrast test: compared with conventional medicament, the pharmaceutical composition of the embodiment of the present invention 1 and 2 is aspect treatment ox gastroenteritis, have average daily ingestion amount and also increase, average body condition divides (BCS) also relatively to make moderate progress, and no longer includes the phenomenon that appetite die-offs or do not eat.

Each group of table 3 is treated respectively the time comparative example (%) of the number of fully recovering afterwards for 6 days

Group	Number of cases	1-2 days	3-4 days	5-6 days
					1 group of embodiment	60	（57）95%	（3）5%	（0）0%
Embodiment 2	60	（59）98.3%	（1）1.7%	（0）0%
					Control group	48	（2）4.2%	（6）12.5%	（40）83.3%

Data from table 3: pharmaceutical composition of the present invention, to treatment ox gastroenteritis, in result for the treatment of, has significant improvement with respect to conventional medicament, have obviously shortened treatment course for the treatment of.

Model case:

In January, 2014 Shanxi Hua Xin plant the oxen of 450 1.5 years old mean aves, nearly 160 oxen ight soil is in the pasty state soft at the initial stage of a disease, the grizzly yellowish-white alternate water sample loose stool of ight soil after several days, abnormal sour smelly, later stage ight soil is dark red, stench, anus redness, around by fleece fecal pollution, lassitude, anorexia, xanthochromia after the first flush of eye conjunctiva, diarrhoea as slurry, ight soil stench and band blood and mucous membrane, thin and weak unable gradually, mouth parched and tongue scorched, shortness of breath, breathes heavily slightly, and pulse condition such as counts accurately at the symptom. Choose 50 ill oxen wherein, start to feed and be added with the feed of the embodiment of the present invention 2 powders, powder is sneaked in conventional feed according to 7g:500g weight ratio, feeds 6 days, and within the 2nd day, ill ox symptom is obviously improved, within the 3rd day, 50 oxen are all fully recovered, continue to feed after 4 days, compared with healthy ox, stool colour, spirit, eye conjunctiva recovers normal, and appetite increases, and does not occur mouth parched and tongue scorched, shortness of breath, breathe heavily slightly, pulse condition such as counts accurately at the symptom, compared with healthy ox, average daily ingestion amount increases, and average body condition divides (BCS) also relatively to make moderate progress.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims

1. treat the pharmaceutical composition of ox gastroenteritis for one kind, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Ageratum conyzoides, Gui Ding, grass-leaved sweetflag, thatch screwpine fruit, iron holly bark, asian tetracera root or leaf, Kaempferia galanga, card are close, emblic leafflower fruit, smallpox of ancient India, oneflower larkspur herb, Herba Violae diamantiacae, thinleaf buckthorn fruit, schefflera arboricola, fourth grass in the last of the ten Heavenly stems, Long Stephania Herb and saline cistanche.

2. the pharmaceutical composition for the treatment of ox gastroenteritis according to claim 1, it is characterized in that, in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Ageratum conyzoides 10-20 weight portion, osmanthus fourth 15-35 weight portion, grass-leaved sweetflag 12-26 weight portion, thatch screwpine fruit 14-32 weight portion, iron holly bark 13-27 weight portion, asian tetracera root or leaf 15-35 weight portion, Kaempferia galanga 10-20 weight portion, block close 12-34 weight portion, emblic leafflower fruit 17-26 weight portion, smallpox 11-31 weight portion of ancient India, oneflower larkspur herb 14-28 weight portion, Herba Violae diamantiacae 10-22 weight portion, thinleaf buckthorn fruit 3-5 weight portion, schefflera arboricola 15-25 weight portion, fourth grass in last of the ten Heavenly stems 10-22 weight portion, Long Stephania Herb 14-28 weight portion and saline cistanche 7-14 weight portion.

3. the pharmaceutical composition for the treatment of ox gastroenteritis according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Ageratum conyzoides 15 weight portions, osmanthus fourth 29 weight portions, grass-leaved sweetflag 23 weight portions, thatch screwpine fruit 30 weight portions, iron holly bark 25 weight portions, asian tetracera root or leaf 34 weight portions, Kaempferia galanga 15 weight portions, block close 20 weight portions, emblic leafflower fruit 24 weight portions, smallpox 31 weight portions of ancient India, oneflower larkspur herb 24 weight portions, Herba Violae diamantiacae 12 weight portions, thinleaf buckthorn fruit 4 weight portions, schefflera arboricola 16 weight portions, fourth grass in the last of the ten Heavenly stems 18 weight portions, Long Stephania Herb 25 weight portions and saline cistanche 10 weight portions.

4. according to the pharmaceutical composition of the treatment ox gastroenteritis described in claim 1-3 any one, it is characterized in that, described pharmaceutical composition also comprises: shepherd's purse ramie, radix stellariae dichotomae, daghestan sweetclover herb, Himalayan Eriosema and canescent wikstroemia.

5. according to the pharmaceutical composition of the treatment ox gastroenteritis described in claim 1-4 any one, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Ageratum conyzoides 10-20 weight portion, osmanthus fourth 15-35 weight portion, grass-leaved sweetflag 12-26 weight portion, thatch screwpine fruit 14-32 weight portion, iron holly bark 13-27 weight portion, asian tetracera root or leaf 15-35 weight portion, Kaempferia galanga 10-20 weight portion, block close 12-34 weight portion, emblic leafflower fruit 17-26 weight portion, smallpox 11-31 weight portion of ancient India, oneflower larkspur herb 14-28 weight portion, Herba Violae diamantiacae 10-22 weight portion, thinleaf buckthorn fruit 3-5 weight portion, schefflera arboricola 15-25 weight portion, fourth grass in last of the ten Heavenly stems 10-22 weight portion, Long Stephania Herb 14-28 weight portion, saline cistanche 7-14 weight portion, shepherd's purse ramie 10-20 weight portion, radix stellariae dichotomae 13-31 weight portion, daghestan sweetclover herb 15-24 weight portion, Himalayan Eriosema 9-18 weight portion and canescent wikstroemia 2-4 weight portion.

6. according to the pharmaceutical composition of the treatment ox gastroenteritis described in claim 1-5 any one, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Ageratum conyzoides 15 weight portions, osmanthus fourth 29 weight portions, grass-leaved sweetflag 23 weight portions, thatch screwpine fruit 30 weight portions, iron holly bark 25 weight portions, asian tetracera root or leaf 34 weight portions, Kaempferia galanga 15 weight portions, block close 20 weight portions, emblic leafflower fruit 24 weight portions, smallpox 31 weight portions of ancient India, oneflower larkspur herb 24 weight portions, Herba Violae diamantiacae 12 weight portions, thinleaf buckthorn fruit 4 weight portions, schefflera arboricola 16 weight portions, fourth grass in the last of the ten Heavenly stems 18 weight portions, Long Stephania Herb 25 weight portions, saline cistanche 10 weight portions, shepherd's purse ramie 14 weight portions, radix stellariae dichotomae 28 weight portions, daghestan sweetclover herb 22 weight portions, Himalayan Eriosema 14 weight portions and canescent wikstroemia 3 weight portions.

7. according to the pharmaceutical composition of the treatment ox gastroenteritis described in claim 1-6 any one, it is characterized in that, the formulation of described pharmaceutical composition is powder-injection, and its preparation method comprises the following steps:

8. according to the pharmaceutical composition of the treatment ox gastroenteritis described in claim 1-6 any one, it is characterized in that, the formulation of described pharmaceutical composition is powder, and its preparation method comprises the following steps:

9. a preparation method for the pharmaceutical composition of the treatment ox gastroenteritis as described in claim 1-6 any one, is characterized in that, the formulation of described pharmaceutical composition is powder-injection, and its preparation method comprises the following steps:

10. a preparation method for the pharmaceutical composition of the treatment ox gastroenteritis as described in claim 1-6 any one, is characterized in that, the formulation of described pharmaceutical composition is powder, and its preparation method comprises the following steps: