CN105660655A - Difenoconazole aromatic-free emulsifiable oil and preparation method thereof - Google Patents
Difenoconazole aromatic-free emulsifiable oil and preparation method thereof Download PDFInfo
- Publication number
- CN105660655A CN105660655A CN201610092425.9A CN201610092425A CN105660655A CN 105660655 A CN105660655 A CN 105660655A CN 201610092425 A CN201610092425 A CN 201610092425A CN 105660655 A CN105660655 A CN 105660655A
- Authority
- CN
- China
- Prior art keywords
- difenoconazole
- aromatic hydrocarbons
- methyl oleate
- emulsifying agent
- cream
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
Abstract
The invention discloses difenoconazole aromatic-free emulsifiable oil and a preparation method thereof. The difenoconazole aromatic-free emulsifiable oil is prepared from, by weight, 25-40% of difenoconazole, 5-20% of an emulsifying agent and the balance methyl oleate. After the methyl oleate and the emulsifying agent are mixed, difenoconazole raw materials can be well dissolved, and the obtained emulsifiable oil has the good stability and dispersibility. The methyl oleate is adopted for replacing a benzene series solvent in the oil, so that the usage amounts of solvents such as benzene, methylbenzene and xylene in the emulsifiable oil are decreased, and damage of the benzene series solvent to the environment and human health is lowered; the methyl oleate is wide in source and low in cost, and therefore the cost of the emulsifiable oil is lowered.
Description
Technical field
The present invention relates to emulsifiable concentrates for agricultural chemicals field, particularly relate to a kind of Difenoconazole without aromatic hydrocarbons cream and preparation method thereof.
Background technology
Current farm chemical emulsion preparation is the formulations of pesticide that China is traditional, accounts for 40% in various dosage forms, and in annual production more than in 19 kinds of pesticidal preparations products of 5 kilotons, having 11 kinds of Pesticidal products is cream dosage form, accounts for the 60% of sum. The primary solvent used in emulsifiable concentrates for agricultural chemicals is benzene,toluene,xylene, but a large amount of use of benzene, toluene and dimethylbenzene creates many problems, such as benzene, toluene and dimethylbenzene are irritant to skin, mucosa, central nervous system is had anesthetic action, sucks higher concentration in the short time and may occur in which the obvious stimulation symptom of eyes and upper respiratory tract; And often in contact with the synthesis of human deoxyribonucleic acid can be suppressed, cause chromosome mutation, destroy hemopoietic system, leukemogenesis; Benzene, toluene and dimethylbenzene dissolubility in water is little, therefore floating or be distributed in the water surface in oily, causes Fish and other aquatile dead. Additionally, toluene and dimethylbenzene also have stronger volatility and inflammability, in transport and use procedure thereof, there is bigger potential safety hazard.
But at present make the cream preparation of solvent with toluene, dimethylbenzene to be still widely used, this is mainly such cream preparation and is better than other preparation in drug effect, such as wettable powder etc., therefore some special insects are being prevented and treated, such as the aspect such as coccid, aleyrodid is better than other dosage form, and it is becoming present aspect also superior to dosage forms such as water dispersible granules, therefore cream or the formulations of pesticide that China commonly uses at present. Therefore, research and development substitute the hypotoxicity of benzene in cream, toluene and dimethylbenzene, the solvent that environmental hazard is little is very urgent.
Methyl oleate, has another name called octadecenic acid methyl ester, for pale yellow transparent oily liquids, can be miscible in water with dehydrated alcohol, ethanol, and these product are the intermediate of detergent, emulsifying agent, wetting agent and stabilizer. Methyl oleate is a kind of material that nature is very general, content is higher, it is common to be present in the oil substances in plant seed such as Semen Sesami, Semen Brassicae campestris, Semen arachidis hypogaeae, Semen Maydis, camellia oleosa seed, Semen Glycines etc., is also one of the main component of some Animal fat class materials. Methyl oleate can also have methanol and oleic acid to obtain through esterification, its method is: by oleic acid and methanol mixed, add catalyst concentrated sulphuric acid or p-methyl benzenesulfonic acid, it is heated to reflux 10h, cooling, being neutralized to pH value with Feldalat NM is 8 ~ 9, washes with water to neutrality, carry out decompression distillation after drying through anhydrous calcium chloride, obtain methyl oleate.Owing to methyl oleate source is wide, nontoxic and environmental hazard is little, it is substitute the ideal solvent of benzene, toluene and dimethylbenzene in cream.
But when adopting methyl oleate to replace the benzene in cream, toluene and dimethylbenzene, the emulsifying agent of different former pharmacopoeia apoplexy due to endogenous wind cream preparations is not suitable for methyl oleate, it is necessary to research and development are applicable to the emulsifying agent of methyl oleate.
Summary of the invention
It is an object of the invention to provide a kind of originate wide, nontoxic and to the little Difenoconazole of environmental hazard without aromatic hydrocarbons cream.
The Difenoconazole described in the providing preparation method without aromatic hydrocarbons cream is provided.
The above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of Difenoconazole, without aromatic hydrocarbons cream, is got the raw materials ready by following percentage by weight:
Difenoconazole 25% ~ 40%,
Emulsifying agent 5% ~ 20%,
Methyl oleate polishing.
Preferably, described emulsifying agent percentage by weight is 10%.
Preferably, described methyl oleate percentage by weight is 88.2%.
In order to better dissolve former medicine, described emulsifying agent is one or more in farm chemical emulgent, emulsification agent and diesel oil emulsifier.
Preferably, described farm chemical emulgent include 100#, 500#, 1601,1602, OP-7, OP-10,600,600-1,600-2,600-3, BY-110, BY-112, BY-120, BY-130, BY-140,400,403.
Preferably, described emulsifying agent be farm chemical emulgent monomer 100#, 500#, 1601, OP-7, OP-10, emulsification agent mixture.
Preferably, described emulsification agent is formed by multiple the moon/nonionic surfactant and additive compound.
Described Difenoconazole, without aromatic hydrocarbons cream, is prepared according to the following steps:
(1) emulsifying agent is added in appropriate methyl oleate, mix homogeneously;
(2) difenoconazole technical material is added in the solution of step (1) gained, mix homogeneously;
(3) remaining methyl oleate is added in the solution of step (2) gained, mix homogeneously, obtain Difenoconazole without aromatic hydrocarbons cream.
Beneficial effects of the present invention: after the methyl oleate in the present invention mixes with emulsifying agent, it is possible to dissolve difenoconazole technical material well, and the cream obtained has good stability and dispersibility; The present invention adopts methyl oleate to be substituted into the benzene-series solvent in oil, thus decreasing the consumption that makes of benzene in cream, toluene and dimethylbenzene equal solvent, and decreases the harm that environment and human health are caused by benzene-series solvent; And methyl oleate wide material sources, cost are low, thus reducing the cost of cream.
Detailed description of the invention
For describing the technology contents of the present invention in detail, realizing target effect, it is explained in detail below in conjunction with embodiment.
Embodiment 1
The present embodiment provides a kind of Difenoconazole without aromatic hydrocarbons cream, gets the raw materials ready by following percentage by weight:
Difenoconazole 25%,
Emulsifying agent 5%,
Methyl oleate polishing.
The Difenoconazole of the present embodiment, without aromatic hydrocarbons cream, is prepared according to the following steps:
(1) emulsifying agent is added in appropriate methyl oleate, mix homogeneously;
(2) difenoconazole technical material is added in the solution of step (1) gained, mix homogeneously;
(3) remaining methyl oleate is added in the solution of step (2) gained, mix homogeneously, obtain Difenoconazole without aromatic hydrocarbons cream.
Embodiment 2
The present embodiment provides a kind of Difenoconazole without aromatic hydrocarbons cream, gets the raw materials ready by following percentage by weight:
Difenoconazole 30%,
Emulsifying agent 5%,
Methyl oleate polishing.
The Difenoconazole of the present embodiment without aromatic hydrocarbons cream preparation process with embodiment 1.
Embodiment 3
The present embodiment provides a kind of Difenoconazole without aromatic hydrocarbons cream, gets the raw materials ready by following percentage by weight:
Difenoconazole 40%,
Emulsifying agent 5%,
Methyl oleate polishing.
The Difenoconazole of the present embodiment without aromatic hydrocarbons cream preparation process with embodiment 1.
Embodiment 4
The present embodiment provides a kind of Difenoconazole without aromatic hydrocarbons cream, gets the raw materials ready by following percentage by weight:
Difenoconazole 25%,
Emulsifying agent 10%,
Methyl oleate polishing.
The Difenoconazole of the present embodiment without aromatic hydrocarbons cream preparation process with embodiment 1.
Embodiment 5
The present embodiment provides a kind of Difenoconazole without aromatic hydrocarbons cream, gets the raw materials ready by following percentage by weight:
Difenoconazole 30%,
Emulsifying agent 10%,
Methyl oleate polishing.
The Difenoconazole of the present embodiment without aromatic hydrocarbons cream preparation process with embodiment 1.
Embodiment 6
The present embodiment provides a kind of Difenoconazole without aromatic hydrocarbons cream, gets the raw materials ready by following percentage by weight:
Difenoconazole 40%,
Emulsifying agent 10%,
Methyl oleate polishing.
The Difenoconazole of the present embodiment without aromatic hydrocarbons cream preparation process with embodiment 1.
Embodiment 7
The present embodiment provides a kind of Difenoconazole without aromatic hydrocarbons cream, gets the raw materials ready by following percentage by weight:
Difenoconazole 25%,
Emulsifying agent 15%,
Methyl oleate polishing.
The Difenoconazole of the present embodiment without aromatic hydrocarbons cream preparation process with embodiment 1.
Embodiment 8
The present embodiment provides a kind of Difenoconazole without aromatic hydrocarbons cream, gets the raw materials ready by following percentage by weight:
Difenoconazole 30%,
Emulsifying agent 15%,
Methyl oleate polishing.
The Difenoconazole of the present embodiment without aromatic hydrocarbons cream preparation process with embodiment 1.
Embodiment 9
The present embodiment provides a kind of Difenoconazole without aromatic hydrocarbons cream, gets the raw materials ready by following percentage by weight:
Difenoconazole 40%,
Emulsifying agent 15%,
Methyl oleate polishing.
The Difenoconazole of the present embodiment without aromatic hydrocarbons cream preparation process with embodiment 1.
Embodiment 10
The present embodiment provides a kind of Difenoconazole without aromatic hydrocarbons cream, gets the raw materials ready by following percentage by weight:
Difenoconazole 25%,
Emulsifying agent 20%,
Methyl oleate polishing.
The Difenoconazole of the present embodiment without aromatic hydrocarbons cream preparation process with embodiment 1.
Embodiment 11
The present embodiment provides a kind of Difenoconazole without aromatic hydrocarbons cream, gets the raw materials ready by following percentage by weight:
Difenoconazole 30%,
Emulsifying agent 20%,
Methyl oleate polishing.
The Difenoconazole of the present embodiment without aromatic hydrocarbons cream preparation process with embodiment 1.
Embodiment 12
The present embodiment provides a kind of Difenoconazole without aromatic hydrocarbons cream, gets the raw materials ready by following percentage by weight:
Difenoconazole 40%,
Emulsifying agent 20%,
Methyl oleate polishing.
The Difenoconazole of the present embodiment without aromatic hydrocarbons cream preparation process with embodiment 1.
In embodiment 1 to embodiment 12, described emulsifying agent is one or more in farm chemical emulgent, emulsification agent and diesel oil emulsifier, described farm chemical emulgent include 100#, 500#, 1601,1602, OP-7, OP-10,600,600-1,600-2,600-3, BY-110, BY-112, BY-120, BY-130, BY-140,400,403.
Preferably, described emulsifying agent be farm chemical emulgent monomer 100#, 500#, 1601, OP-7, OP-10, emulsification agent mixture, this emulsifying agent mixture accounts for better effects if when the percentage by weight of described emulsifiable concentrate formulation is 10%.
Emulsification agent of the present invention is formed by multiple the moon/nonionic surfactant and additive compound, for weak yellow liquid, soluble in water, in acid, alkali, oxidant all very stable, there is the functions such as emulsifying, dispersion, removing oil, decontamination, animals and plants and mineral greasy dirt cleansing power are very strong, it is widely used in all kinds of cleaning industry, such as ink cleaning, engine washing, die casting cleaning etc.
Methyl oleate of the present invention accounts for the percentage by weight of emulsifiable concentrate formulation preferably 88.2%.
After methyl oleate in the present invention mixes with mentioned emulsifier, difenoconazole technical material can be dissolved well, and the cream obtained has good stability and dispersibility, thus decreasing the consumption that makes of benzene in cream, toluene and dimethylbenzene equal solvent, and decrease the harm that environment and human health are caused by benzene-series solvent.
The foregoing is only embodiments of the invention; not thereby the scope of the claims of the present invention is limited; every equivalent transformation utilizing description of the present invention to make, or directly or indirectly it is used in other relevant technical fields, all in like manner include in the scope of patent protection of the present invention.
Claims (8)
1. a Difenoconazole is without aromatic hydrocarbons cream, it is characterised in that get the raw materials ready by following percentage by weight:
Difenoconazole 25% ~ 40%,
Emulsifying agent 5% ~ 20%,
Methyl oleate polishing.
2. Difenoconazole according to claim 1 is without aromatic hydrocarbons cream, it is characterised in that described emulsifying agent optimum weight percentage ratio is 10%.
3. Difenoconazole according to claim 1 is without aromatic hydrocarbons cream, it is characterised in that described methyl oleate optimum weight percentage ratio is 88.2%.
4. Difenoconazole according to claim 1 is without aromatic hydrocarbons cream, it is characterised in that described emulsifying agent is one or more in farm chemical emulgent, emulsification agent and diesel oil emulsifier.
5. Difenoconazole according to claim 4 is without aromatic hydrocarbons cream, it is characterized in that, described farm chemical emulgent include 100#, 500#, 1601,1602, OP-7, OP-10,600,600-1,600-2,600-3, BY-110, BY-112, BY-120, BY-130, BY-140,400,403.
6. Difenoconazole according to claim 4 is without aromatic hydrocarbons cream, it is characterised in that described emulsifying agent be farm chemical emulgent monomer 100#, 500#, 1601, OP-7, OP-10, emulsification agent mixture.
7. Difenoconazole according to claim 4 is without aromatic hydrocarbons cream, it is characterised in that described emulsification agent is formed by multiple the moon/nonionic surfactant and additive compound.
8. the Difenoconazole according to claim 1 to 7 any one is without the preparation method of aromatic hydrocarbons cream, it is characterised in that be prepared according to the following steps:
Emulsifying agent is added in appropriate methyl oleate, mix homogeneously;
Difenoconazole technical material is added in the solution of step (1) gained, mix homogeneously;
Remaining methyl oleate is added in the solution of step (2) gained, mix homogeneously, obtain Difenoconazole without aromatic hydrocarbons cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610092425.9A CN105660655A (en) | 2016-02-19 | 2016-02-19 | Difenoconazole aromatic-free emulsifiable oil and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610092425.9A CN105660655A (en) | 2016-02-19 | 2016-02-19 | Difenoconazole aromatic-free emulsifiable oil and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105660655A true CN105660655A (en) | 2016-06-15 |
Family
ID=56304650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610092425.9A Pending CN105660655A (en) | 2016-02-19 | 2016-02-19 | Difenoconazole aromatic-free emulsifiable oil and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105660655A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194606A (en) * | 2006-12-04 | 2008-06-11 | 湖南万家丰科技有限公司 | Pesticide missible oil preparation containing biological diesel oil solvent |
| CN101606517A (en) * | 2009-07-27 | 2009-12-23 | 深圳诺普信农化股份有限公司 | A kind of farm chemical emulsion preparation |
| CN101984807A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Missible oil preparation using turpentine-based vegetable oil as solvent and preparation method thereof |
| CN104823969A (en) * | 2015-05-28 | 2015-08-12 | 苏州丰倍生物科技有限公司 | Development and application of fatty acid methyl ester serving as environment-friendly solvent in pesticide preparations |
-
2016
- 2016-02-19 CN CN201610092425.9A patent/CN105660655A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194606A (en) * | 2006-12-04 | 2008-06-11 | 湖南万家丰科技有限公司 | Pesticide missible oil preparation containing biological diesel oil solvent |
| CN101606517A (en) * | 2009-07-27 | 2009-12-23 | 深圳诺普信农化股份有限公司 | A kind of farm chemical emulsion preparation |
| CN101984807A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Missible oil preparation using turpentine-based vegetable oil as solvent and preparation method thereof |
| CN104823969A (en) * | 2015-05-28 | 2015-08-12 | 苏州丰倍生物科技有限公司 | Development and application of fatty acid methyl ester serving as environment-friendly solvent in pesticide preparations |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2009235913B2 (en) | Aqueous disinfectant formulation comprising a phenolic compound, a surfactant, and a solvent. | |
| CN105660631A (en) | Clethodim aromatic-free missible oil and preparation method thereof | |
| CN102754647B (en) | Pesticide composition containing thiosulfonic acid ester fungicide | |
| CN103563901B (en) | A kind of Efficient insecticidal composition containing propylene glycol alginate | |
| EP0064478B1 (en) | Herbicidal agents | |
| CN105660654A (en) | Propiconazole arene-free missible oil and preparation method thereof | |
| CN105685063A (en) | nicotine/matrine aromatic-free emulsifiable concentrate and preparation method thereof | |
| CN105660678A (en) | Imidacloprid aromatic-free emulsifiable oil and preparation method thereof | |
| CN105660626A (en) | Indoxacarb aromatic-free missible oil and preparation method thereof | |
| CN105660652A (en) | Tebuconazole aromatic-free missible oil and preparation method thereof | |
| CN105685089A (en) | Omethoate aromatic-free emulsifiable concentrate and preparation method thereof | |
| CN105660682A (en) | Chlorpyrifos non-aromatic missible oil and reparation method thereof | |
| CN105660655A (en) | Difenoconazole aromatic-free emulsifiable oil and preparation method thereof | |
| CN105660656A (en) | Benzyl propiconazole aromatic-free emulsifiable oil and preparation method thereof | |
| CN105660683A (en) | Aacitretin triazophos aromatic-free emulsifiable oil and preparation method thereof | |
| CN105660614A (en) | Pyraclostrobin arene-free missible oil and preparation method thereof | |
| CN105660630A (en) | Sethoxydim aromatic-free missible oil and preparation method thereof | |
| CN105660664A (en) | Azadirachtin aromatic-free missible oil and preparation method thereof | |
| CN105660613A (en) | Fluoroglycofen-ethyl aromatic-free missible oil and preparation method thereof | |
| CN105685023A (en) | Beta-cypermethrin-containing aromatic-free emulsifiable concentrate and preparation method thereof | |
| CN105685079A (en) | Emamectin.hexaflumuron aromatic-free emulsifiable oil and preparation method thereof | |
| CN105685043A (en) | Aromatic-free isoprothiolane missible oil and method for preparing same | |
| CN105660653A (en) | Triadimefon arene-free missible oil and preparation method thereof | |
| CN102228055A (en) | Pesticide composite containing fenazaquin | |
| CN107593696A (en) | Clodinafop-propargyl missible oil of high-efficiency environment friendly and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160615 |
|
| WD01 | Invention patent application deemed withdrawn after publication |