CN105647803B - Biometric print machine print module and biometric print machine - Google Patents
Biometric print machine print module and biometric print machine Download PDFInfo
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- CN105647803B CN105647803B CN201511025784.4A CN201511025784A CN105647803B CN 105647803 B CN105647803 B CN 105647803B CN 201511025784 A CN201511025784 A CN 201511025784A CN 105647803 B CN105647803 B CN 105647803B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
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Abstract
The present invention relates to a kind of biometric print machine print modules and biometric print machine, print module to include：Support member and the swingle equipped with nutrient solution supply interface (14), swingle is rotatably supported in support member, the surface of swingle is used to receive the biological prepared Chinese ink of printing head offer, swingle includes the hollow pipeline section (22) with center through hole, and the tube wall of hollow pipeline section (22) is equipped with the permeability hole (26) connected with center through hole, nutrient solution supply interface connects external nutrient solution importing swingle with the center through hole of swingle.The biometric print machine print module of the present invention can supply extraneous nutrient solution to interface by nutrient solution in print procedure and import inside swingle, exudation is to supply the cell and biological tubular tissue on swingle from permeability hole again, so as to improve the survival rate of cell and biological function.
Description
Technical field
The present invention relates to biometric print technical field more particularly to a kind of biometric print machine print modules and biometric print
Machine.
Background technology
Biological 3D printing refers to the principle and method by 3D printing, by biomaterial (including natural biologic material, synthesis
Biomaterial or cell solution) it prints as the three-dimensional structure designed, it is different from common 3D printing technique, biological 3D printing
The biological tissue of technology production or organ also have certain biological function, need to be provided for the further growth of cell and tissue
Condition, just because of above-mentioned characteristic, biological 3D printing technique is faced with the technical issues of many specific in development.
Wherein, in biological 3D printing field, it is known as cell 3D printing technique, people using cell as the technology of printed material
It can utilize cell and biocompatible materials that biological prepared Chinese ink is made, make nozzle mobile and spray biological prepared Chinese ink, pass through program
Nozzle movement is controlled, by biological prepared Chinese ink according to preset target print, with according to the three-dimensional digital model printing shaping of object.
In medical field, the method for commonly using biology 3D printing makes cavity active mass such as artificial blood vessel, this is treats many blood vessel classes
Disease provides approach.
In the prior art for printing the printer of blood vessel, including swingle and printing head, the length of swingle and big
The small shape of blood vessel printed as needed and size are designed, and one end of swingle is supported by stent and driven by motor,
The other end is hanging, and printing head is located above swingle, and can be moved relative to the surface of swingle.Printing head will during work
To form biological vascular tissue on biological ink jet to the surface of swingle, after printing, by the rotation with vascular tissue
Bull stick, which is removed, to be put into bio-incubator, is added in various growth factors and is promoted differentiation factor, accelerates vascular tissue's structure and various
Physiological function is reached maturity, the blood vessel needed.
But cell is ejected on swingle after formation biology vascular tissue, until whole by such scheme in printing head
In this period that a print procedure terminates, cell and biological vascular tissue on swingle lack external nourishment supply,
Its cell survival and biological function realization will all be affected.As it can be seen that for biological 3D printing, nutrition supply is essential
Important link, and how carrier on dynamic swingle provides nutrient solution, then the always insoluble skill in this field
Art problem.
Invention content
The purpose of the present invention is to propose to a kind of biometric print machine print module and biometric print machines, can be in print procedure
By the cell and biological tubular tissue on extraneous nutrient solution supply swingle.
To achieve the above object, first aspect present invention provides a kind of biometric print machine print module, including：Support portion
Part and the swingle equipped with nutrient solution supply interface, the swingle are rotatably supported in the support member, the rotation
The surface of bull stick is used to receive the biological prepared Chinese ink of printing head offer, and the swingle includes the hollow tube with center through hole
Section, and the tube wall of hollow pipeline section is equipped with the permeability hole that connect with the center through hole, the nutrient solution supply interface with it is described
The center through hole of swingle connects external nutrient solution importing the swingle.
Further, the support member includes support portion and nutrient solution delivery section, and the nutrient solution supply interface is located at
On the circumferencial direction of the swingle, the swingle is rotatably supported on the support portion, the nutrient solution delivery section
It is set on the swingle and with delivery section interface, is equipped in the nutrient solution delivery section and the delivery section orifice
, the conversion cavity for surrounding the swingle in a circumferential direction, center through hole described in nutrient solution supply orifice with
The conversion cavity.
Further, sealing device is further included, the sealing device is located at the nutrient solution delivery section and the swingle
Between.
Further, the nutrition liquid bath for providing nutrient solution to the swingle is further included, the nutrition liquid bath has
Slot interface, the slot interface are connect with the delivery section interface by nutrient solution conveying device, and the nutrient solution conveying device is used
Enter the swingle in controlling the nutrient solution in the nutrition liquid bath.
Further, the nutrient solution conveying device is additionally operable to the flow velocity and flow of control nutrient solution；Or the biology
Printer print module further includes the nutrient solution control device connected with the nutrient solution conveying device, the slot interface with it is described
Delivery section interface is connected by nutrient solution conveying device with the nutrient solution control device, and the nutrient solution control device is used to control
The flow velocity and flow of nutrient solution processed.
Further, temperature detection part for detecting solution temperature is further included or for controlling solution temperature
Nutrient solution temperature control device.
Further, the nutrient solution temperature control device includes：Semiconductor chilling plate, temperature controller and radiator, institute
State the bottom that semiconductor chilling plate is set to the nutrition liquid bath, under the control of the temperature controller to the nutrition
Liquid bath is heated or cooled, and the semiconductor chilling plate has temperature control end and non-temperature control end, and the temperature control end is towards the battalion
Nutrient solution slot is set, and the non-temperature control end is set towards the radiator.
Further, heat-conducting plate or soaking plate are equipped between the nutrition liquid bath and the semiconductor chilling plate.
Further, the swingle further includes group section, and the nutrient solution supply interface is arranged on the group section,
The group section is removably coaxially located at the end of the hollow pipeline section, and the group section is rotatably supported at the support
On component, the group section can be actuated to drive the hollow pipeline section rotation.
Further, connector is further included, the group section is connected by the end of the connector and the hollow pipeline section
It connects.
Further, the connector is screw thread coupling.
Further, the hollow portion with nutrient solution supply orifice, the hollow portion are equipped in the group section
It connects that nutrient solution is imported the hollow pipeline section by the hollow portion with the center through hole of the hollow pipeline section.
Further, the group section is connect with the end part seal of the hollow pipeline section.
Further, servo motor is further included, the servo motor is arranged in parallel with the swingle, the servo motor
Pass through synchronous pulley and synchronous band connection with the swingle.
To achieve the above object, second aspect of the present invention provides a kind of biometric print machine, including described in above-described embodiment
Print module.
Based on above-mentioned technical proposal, biometric print machine print module of the invention, by setting nutrient solution on swingle
Interface and permeability hole are supplied, extraneous nutrient solution can be supplied to interface by nutrient solution in print procedure and imported in swingle
Portion, then oozed out from permeability hole to supply the cell and biological tubular tissue on swingle, so as to cell and biological tubular tissue
Protection is formed, and then improves the survival rate and biological function of cell.
Description of the drawings
Attached drawing described herein is used to provide further understanding of the present invention, and forms the part of the application, this hair
Bright illustrative embodiments and their description do not constitute improper limitations of the present invention for explaining the present invention.In the accompanying drawings：
The three dimensional structure diagram of one embodiment of Fig. 1 biometric print machine print modules of the present invention；
Fig. 2 is the vertical view of biometric print machine print module shown in Fig. 1；
Fig. 3 is the A-A sectional views of biometric print machine print module shown in Fig. 2；
Fig. 4 is the partial enlarged view B of biometric print machine print module shown in Fig. 2.
Reference sign
1- installing plates；2- servo motors；3- synchronous pulleys；4- tension-regulators；The first pipe fittings of 5-；6- second
Pipe fitting；7- third pipe fittings；The 4th pipe fittings of 8-；The 5th pipe fittings of 9-；The 6th pipe fittings of 10-；11- nutrition liquid baths；
12- cooled plates；13- semiconductor chilling plates；14- nutrient solutions supply interface；15- group sections；16- end caps；17- first
Seat；18- bearings；19- nutrient solution delivery sections；20- sealing rings；21- connectors；The hollow pipeline sections of 22-；The second bearings of 23-；
24- group sections；25- converts cavity；26- permeability holes.
Specific embodiment
The present invention described further below.In the following paragraphs, the different aspect of embodiment is defined in more detail.So
The various aspects of restriction can be combined with any other one side or many aspects, can not be combined unless explicitly stated otherwise.Especially,
Be considered as preferred or advantageous any feature can be considered as preferred or advantageous feature with other one or more.
The terms descriptions merely for convenience such as " first " that occurs in the present invention, " second " have same names to distinguish
Different building blocks, be not offered as successively or primary-slave relation.
In the description of the present invention, it is to be understood that the fingers such as term " on ", " under ", "front", "rear", " left side " and " right side "
The orientation or position relationship shown is based on orientation shown in the drawings or position relationship, is for only for ease of the description present invention, without
It is instruction or implies that signified device there must be specific orientation, with specific azimuth configuration and operation, therefore not be understood that
For limiting the scope of the invention.
The present invention provides a kind of biometric print machine print module, as shown in Figures 1 to 4, including：It support member and is equipped with
Nutrient solution supplies the swingle of interface 14, and swingle is rotatably supported in support member, and the surface of swingle is used to receive
The biological prepared Chinese ink that printing head provides, swingle include the hollow pipeline section 22 with center through hole, and the tube wall of hollow pipeline section 22
It is equipped with the permeability hole 26 that connect with center through hole, nutrient solution supply interface is connected with the center through hole of swingle with by outside
Nutrient solution imports swingle.
Moreover, by adjusting the distribution of permeability hole 26 and size on swingle, it is adapted to different-thickness, length and property
Biological tubular tissue printing needs.Such as：Biological tubular tissue can be blood vessel.It, can be in addition, nutrient solution is as needed
By the way of disposable, biological safety can be improved.
Extraneous nutrient solution can be passed through battalion by the biometric print machine print module of the embodiment of the present invention in print procedure
Nutrient solution supply interface 14 is imported inside swingle, then oozed out from permeability hole 26 to supply the cell and biological tubular on swingle
Tissue so as to organize the formation of protection to cell and biological tubular, and then improves the survival rate and biological function of cell.
Swingle in the embodiment can only include hollow pipeline section 22 or only be equipped with switching in one end of hollow pipeline section 22
Section, can also take structure shown in Fig. 3, i.e. swingle includes hollow pipeline section 22 and the switching for being connected to hollow 22 both ends of pipeline section
Section 15 and group section 24, group section 15 and group section 24 are respectively the first swivel adapter and the second swivel adapter.It gives below
The each embodiment gone out for the swingle of structure is formed shown in Fig. 3 to illustrate.
In order to be guided nutrient solution to the swingle of rotation from fixed structure, two kinds of lead at least may be used
Enter mode：
First, nutrient solution can be imported from the end of swingle by delivery pipe, needing in this case will be in swingle
The center through hole in portion penetrates through in an axial direction, and needs to set sound crossover sub in the junction of delivery pipe and swingle.
Second, nutrient solution supply interface 14 is located on the circumferencial direction of swingle.Specifically, swingle includes hollow pipeline section
22 and the group section 15 and group section 24 at hollow 22 both ends of pipeline section are connected to, group section 15 and group section 24 are respectively the first rotation
Adapter and the second swivel adapter.Correspondingly, nutrient solution supply interface 14 is located at the first swivel adapter and the second rotation is suitable
On the circumferencial direction of orchestration, two nutrient solution delivery sections 19 are respectively sleeved on the first swivel adapter and the second swivel adapter
And with delivery section interface, enlarged drawing B shown in Figure 4, be equipped in nutrient solution delivery section 19 it is with delivery section orifice,
The conversion cavity 25 of swingle is surrounded in a circumferential direction, and for the flowing of nutrient solution, nutrient solution supply interface 14 connects center
Through-hole and conversion cavity 25.For a kind of specific structure, conversion cavity 25 is on the interlude edge of 19 endoporus of nutrient solution delivery section
Own axes open up, and surround corresponding swivel adapter in a circumferential direction, it is preferable that convert cavity 25 as cylindrical empty
Chamber.
In order to which nutrient solution is enable to flow into the center through hole of hollow pipeline section 22 from nutrient solution supply interface 14, the first rotation is suitable
Orchestration and the second swivel adapter close to one end of hollow pipeline section 22 from being equipped with and being connected with nutrient solution supply interface 14
Empty portion, hollow portion are connected with the center through hole of hollow pipeline section 22, nutrient solution is imported hollow pipeline section 22 by hollow portion.It is preferred that
Ground, nutrient solution supply interface 14 is the hole radially opened up on the outer wall of the first swivel adapter and the second swivel adapter.
The embodiment that nutrient solution supply interface 14 is located on swingle circumferencial direction can make nutrient solution supply interface 14 exist
Any moment is all immersed in the nutrient solution riddled in conversion cavity 25, is solved nutrient solution and is entered movement knot from fixed structure
The technical barrier of structure, but also a part of nutrient solution can be stored in advance in conversion cavity 25, so as to make the supply of nutrient solution
More stablize.
In this embodiment, support member can include support portion and nutrient solution delivery section 19, the first swivel adapter and
Second swivel adapter is rotatably supported on support portion, both can be designed as between support portion and nutrient solution delivery section 19 solely
Vertical structure is also designed to the structure of monoblock type, here to the position of support portion and nutrient solution delivery section 19 along rotation rod axis
Putting relationship, there is no limit.In figure 3, support portion is respectively the first bearing 17 and the second bearing 23 being fixed on installing plate 1, the
One bearing 17 is supported the first swivel adapter by bearing 18, and the second bearing 23 is by bearing to the second swivel adapter
It is supported, the use of bi-lateral support structure, improves the stability of rotation of swingle.
Further, nutrient solution is adapted to from nutrient solution delivery section 19 with the first swivel adapter or the second rotation in order to prevent
Clearance leakage between device, between 19 and first swivel adapter of nutrient solution delivery section and nutrient solution delivery section 19 and
Sealing device, such as sealing ring 20 are set between two swivel adapters, concretely O-ring seal.Preferably, in conversion cavity
25 both sides, which are respectively provided to a few sealing ring 20, can reach preferable sealing effect.Circumferential from group section imports nutrition
The embodiment of liquid can be more prone to the setting of sealing ring.Moreover, also should between the end of group section and hollow pipeline section 22
It is connected and sealed.
In order to be biological tubular tissue with nutrient liquid in print procedure, biometric print machine print module, which further includes, to be used for
The nutrition liquid bath 11 of nutrient solution is provided to swingle, nutrition liquid bath 11 has slot interface.In one embodiment, slot interface with it is defeated
Portion's interface is sent to be connected by nutrient solution conveying device, nutrient solution conveying device is used to control the nutrient solution in nutrition liquid bath 11 smooth
Ground enters swingle.For example, pump can be set between slot interface and delivery section interface, to promote the flowing of nutrient solution.Further
Ground, nutrient solution conveying device can also control the flow velocity and flow of nutrient solution, the adjustable circulating pump of flow specifically can be used, such as can
Think peristaltic pump or gear pump etc..
In another embodiment, biometric print machine print module further includes the nutrient solution connected with nutrient solution conveying device
Control device, slot interface are connect with delivery section interface by nutrient solution conveying device and nutrient solution control device, nutrient solution control
Device is used to control the flow velocity and flow of nutrient solution.For example, circulating pump and flow control valve are used cooperatively.
It,, can also be indirectly by adjusting the flow velocity and flow of nutrient solution in print procedure for both embodiments
The temperature control capacity of swingle is adjusted, cooling and heating for printing or largely print for high temperature provides the foundation.It is rotated in swingle
During, it can decide whether to open nutrient solution cycle as needed.
A kind of concrete mode that each interface is set on nutrition liquid bath 11 and nutrient solution delivery section 19 is presented below.Such as figure
Shown in 1, the delivery section interface in nutrient solution delivery section 19 includes：It is located at left side (on the basis of the direction of Fig. 3) nutrient solution conveying
The first pipe fitting 5 in portion 19 and the second pipe fitting 6 being located in right side nutrient solution delivery section 19.Slot on nutrition liquid bath 11
Interface includes：7 and the 4th pipe fitting 8 of third pipe fitting being located on nutrition liquid bath 11.Circulating pump can be located at the first pipe fitting 5
Between the 4th pipe fitting 8 or it is located between the second pipe fitting 6 and third pipe fitting 7, for promoting the flowing of nutrient solution,
The flow path of nutrient solution will be described in the operation principle of subsequent descriptions printer, wouldn't be described in detail here.From pipe-line layout
Convenient and aesthetics considers, by the first pipe fitting 5, the second pipe fitting 6, third pipe fitting 7, the 4th pipe fitting 8 and is set to
5th pipe fitting 9 of the side of cooled plate 12 and the 6th pipe fitting 10 are arranged in the same side of printer.
In order to ensure the activity of biological cell in print procedure, the nutrient solution provided needs to be maintained at certain temperature range
It is interior, it may be provided for the temperature detection part of detection solution temperature thus.In a kind of achievable embodiment, following
Ring pump outlet be equipped with temperature detection part, for obtaining the outlet temperature of circulating pump, in conjunction with nutrient solution circulation time just
Whether the nutrient solution in energy comprehensive descision swingle reaches the temperature of needs.Turn in addition, temperature-detecting device can also be arranged on
It changes in cavity 25 or positions is waited in nutrition liquid bath 11.
In one embodiment of the invention, printer further includes that the nutrient solution temperature control of solution temperature is controlled to fill
It puts.As shown in figure 3, nutrient solution temperature control device includes：At least one semiconductor chilling plate 13, temperature controller and radiator,
At least one semiconductor chilling plate 13 is set to the outside of nutrition liquid bath 11, for being heated under the control of a temperature controller
Or cooling.Set multiple semiconductor chilling plates 13 that can effectively promote the power of refrigeration or heating, moreover it is possible to play redundancy backup
Effect.More preferably, gap can be set between two adjacent semiconductor chilling plates 13, semiconductor chilling plate 13 to be facilitated to pacify
Dress and wiring, wiring, which is placed in gap, to play a protective role.Wherein, semiconductor chilling plate 13 has temperature control end and non-control
Wen Duan, temperature control end are set towards nutrition liquid bath 11, to realize the temperature of control nutrition liquid bath 11 and then control in nutrition liquid bath 11
Solution temperature purpose, non-temperature control end towards radiator set.
In specific structure design, nutrition liquid bath 11 is located at the underface of swingle, and radiator includes cooled plate 12,
Semiconductor chilling plate 13 is located at 11 lower section of nutrition liquid bath, for automatically being changed by program under the control of external temperature controller
Become operating mode, including heating or refrigeration mode；Cooled plate 12 is located at the lower section of semiconductor chilling plate 13, and is fixed on installing plate
On 1, for taking away the heat generated when semiconductor chilling plate 13 works, wherein, cooled plate 12 can also use other heat dissipations to fill
Put replacement, such as fan coolling etc..
In order to facilitate the fixation of semiconductor chilling plate 13, it is more than slot in one size of envisaged underneath of rectangle nutrition liquid bath 11
The heat-conducting plate or soaking plate of body floor space, the even heat that on the one hand semiconductor chilling plate 13 can be generated to nutrition liquid bath
11 transmit, and on the other hand semiconductor chilling plate 13 can also be clipped between pedestal and cooled plate 12, and by the four of pedestal
Week sets bolt to realize the fixation with cooled plate 12.Polylith semiconductor chilling plate 13 can be arranged side by side.Such as due to partly leading
Body cooling piece 13 is generally square, and in order to be uniformly heated up to rectangle nutrition liquid bath 11, two block semiconductors may be used
Cooling piece 13 is arranged side by side.As depicted in figs. 1 and 2, the side of cooled plate 12 is equipped with the 5th pipe fitting 9 and the 6th pipe fitting 10,
5th pipe fitting 9 and the 6th pipe fitting 10 connect the inlet and outlet of external water-cooling circulating system respectively, for taking away
The heat that semiconductor chilling plate 13 generates when working.
When needing heating, temperature control system is in heated condition, and the temperature control end of semiconductor chilling plate 13 is hot face at this time, and
Thermogenetic heat transfer will be added to realize the purpose to heat up to nutrient solution to the nutrient solution in nutrition liquid bath 11.Conversely, work as
When needing cooling, the temperature control end of semiconductor chilling plate 13 becomes huyashi-chuuka (cold chinese-style noodles), to absorb the heat of nutrient solution in nutrition liquid bath 11, realizes
To the purpose that nutrient solution cools down, meanwhile, the non-temperature control end of semiconductor becomes hot face, transfers heat to cooled plate 12, with
Just the temperature difference of 13 cold and hot surface of semiconductor chilling plate is reduced, increases refrigeration effect.
Also there are another drawbacks for printer of the prior art, after each printing, will unload swingle
When be required for together removing the support construction of end so that disassembly process is relatively complicated, and is difficult to ensure that the essence installed every time
Degree is consistent；And when needing to print the biological tubular tissue of different-diameter, it is necessary to be changed to the swingle of respective diameters, make
It obtains support construction to be also required to redesign, makes the versatility of the printer and adaptability poor.
In order to solve this problem, in the improved embodiment of the present invention, swingle is also wrapped in addition to including hollow pipeline section 22
Include at least one group section (group section 15 and 24 is respectively the first swivel adapter and the second swivel adapter in Fig. 3), nutrition
Liquid supply interface 14 is arranged on group section 15 and 24, and group section is removably coaxially located at the end of hollow pipeline section 22, and
It is rotatably supported in support member, can be actuated to that hollow pipeline section 22 is driven to rotate, it is real so as to coordinate with printing head
Existing biological tubular tissue or the printing of other cavity active mass.
The biometric print machine print module of the embodiment, by being designed as being segmented dismountable structure by swingle, and by
Support member is supported group section, avoids the structure being directly supported in the prior art to the end of swingle, energy
It is enough easily to remove swingle after biological tubular tissue prints, dismounting support member is not needed to, is equally beaten in next time
Also it can facilitate installation swingle during print so that handling are more convenient, so as to save the time-write interval, and are easily guaranteed that printing
The installation accuracy of machine.In addition, when needing to print the biological tubular tissue of different-diameter, hollow pipeline section need to be only provided for simple replacement of with turning
Connect the interface of section, you can easily replace the swingle of different size to print different biological tubular tissues.
In a kind of structure type, only with a group section, which is connected to one end of hollow pipeline section, the other end
Vacantly, when needing to dismount swingle, it is only necessary to disconnect or connect the interface section of hollow pipeline section and group section between the two, no
It is related to the dismounting of support construction.
In another structure type, using two group sections, in the embodiment shown in fig. 3, group section 15 is first
Swivel adapter, group section 24 are the second swivel adapter, are removably coaxially located at the both ends of hollow pipeline section 22, support respectively
Component is supported two group sections, so as to realize support to swingle indirectly, drive one of group section or
Two group sections of driving just can drive hollow pipeline section 22 to rotate simultaneously, thus with printing head tri- directions of X, Y and Z at least it
One movement matches so that the biological prepared Chinese ink that printing head sprays is attached to the appearance of hollow pipeline section 22 according to scheduled track
Face, so as to fulfill the printing of biological tubular tissue.
For the embodiment using two group sections, due to biological tubular tissue in printing using swingle as matrix, and
And swingle uses the form of both ends support, can so that rotation is more steady, thus printing longer biological tubular tissue
When, higher precision can be obtained, reduces to the greatest extent due to gravity and swingle is made to deform, so as to influence biological prepared Chinese ink
Preset movement locus.After printing, hollow pipeline section 22 and group section can be separated to realize dismounting, and be put into life
In object incubator, add in various growth factors and promote differentiation factor, accelerate biological tubular institutional framework and various physiological functions hair
Be bred as it is ripe, with the biological tubular tissue needed.When needing to print again, then will be corresponding with biological tubular tissue diameter
Hollow pipeline section 22 is installed on group section.
Following various embodiments will for realizing the printing of biological tubular tissue using the printer of two group sections into
Row explanation.
In order to realize being detachably connected between hollow pipeline section 22 and group section, in a kind of way of realization, referring to Fig. 3,
The printer further includes two connectors 21, and the first swivel adapter and the second swivel adapter pass through a connector 21 respectively
It is connected to the both ends of hollow pipeline section 22.Preferably, connector 21 is screw thread coupling, i.e., opens up threaded hole on connector 21,
Axial two sections of diameters respectively with swivel adapter and hollow pipeline section 22 of threaded hole are adapted, the spiral shell with swivel adapter cooperation
Pit is equipped with surplus with the axial length of aperture smaller in the threaded hole of hollow pipeline section 22 cooperation；It is and suitable in the first rotation
The linkage section setting external screw thread of orchestration and the second swivel adapter and hollow pipeline section 22, can be realized by the cooperation of internal and external threads
It is detachably connected.
When the printing of biological tubular tissue, which finishes, to be needed to remove hollow pipeline section 22, it is only necessary to rotate two connectors 21, example
Such as, two connectors 21 is made to be moved to both ends respectively when the axial length of the threaded hole coordinated with swivel adapter is equipped with surplus
It is dynamic, you can to remove hollow pipeline section 22；When needing to print biological tubular tissue, hollow pipeline section 22 is docked at the first rotation and is fitted
Between orchestration and the second swivel adapter, then two connectors 21 are rotated, for example, in the threaded hole coordinated with swivel adapter
Axial length makes two connectors 21 mobile to centre respectively when being equipped with surplus, you can the installation of hollow pipeline section 22 is realized, by spiral shell
After line connector locking, during can external rotary power be transferred to by the first swivel adapter or the second swivel adapter
Blank pipe section 22.As can be seen that causing to dismount by the way of screw thread coupling more convenient, the support knot to both ends will not relate to
Structure, so as to ensure the installation accuracy of printer, it is ensured that after hollow pipeline section 22 installs, bounce during rotation conforms to
It asks, and then the track that biological prepared Chinese ink is made to be formed on swingle surface is more accurate, to ensure artificial biological tubular organization internal knot
The arrangement of structure more meets demand.
In addition, hollow pipeline section 22 can according to printing different size biological tubular tissue purposes, select diameter from 1.5mm to
The different specifications of 10mm.It is also possible to a series of screw thread couplings to match with biological tubular tissue diameter are made,
When printing the biological tubular tissue of different-diameter, it can only replace hollow pipeline section 22 on the basis of the printer and screw thread connect
It connects device can be realized, without needing the design of change support construction as structure of the prior art, so as to improve printer
Versatility and using flexible.
In addition to using screw thread coupling, those skilled in the art can also use buckle either clip or flange disc-type
Structure realization be detachably connected.
In another way of realization, the end of hollow pipeline section 22 and group section is directly connected to.Here citing is provided several
Plant structure type that can be for reference.If first, only with a group section, group section and the design of hollow pipeline section can be passed through spiral shell
The structure that line is directly connected to.Second, according to two group sections, it can be close in the first swivel adapter and the second swivel adapter
One end of hollow pipeline section radially offers sliding slot, and sliding slot extends to the axis line location of swingle, and the both ends of hollow pipeline section are equal
Equipped with the over-hang part being adapted with sliding slot, only need to be embedded in over-hang part from the open end of sliding slot when mounted, then pass through again
Axis pin or other fasteners are fixed.
For the various embodiments described above, in order to nutrient solution be avoided to be leaked in transmission process as possible, preferably by group section
It is connect with the end part seal of hollow pipeline section 22.For being connected through a screw thread device by the first swivel adapter and the second swivel adapter
The embodiment being connect with hollow pipeline section 22, after screw thread coupling is screwed, you can two swivel adapters of sealing and hollow pipeline section
Gap between 22, and rotary power is transferred to hollow pipeline section 22.
In yet another embodiment of the present invention, printer drives swingle by servo motor 2, and servo motor 2 exists
Under the control of control system, with external printing head Union Movement, the required cavity of spiralization on hollow pipeline section 22
Structure.The use of servo motor 2 can more accurately control the rotating speed of swingle, and position control is carried out to swingle so as to improve
The ability of system, and then can control and carry out Union Movement with printing head.
In a preferred embodiment, in order to save space, vertical view as shown in Figure 2, servo motor 2 and swingle
It is arranged in parallel on installing plate 1, servo motor 2 and the first swivel adapter are by synchronous pulley 3 and synchronous band connection, for will
The power of servo motor 2 is transferred to the first swivel adapter, and the mode of V belt translation is conducive to integral arrangement.Wherein, servo electricity
Machine 2 is connect with the driving wheel of synchronous pulley 3, and the first swivel adapter is connect with the driven wheel of synchronous pulley 3, such as：It can adopt
With the modes such as key connection or fastener connection.Synchronous pulley 3 is by tension-regulator 4 come tension adjusting, such servo electricity
Machine 2 more can carry out position control exactly by synchronous pulley 3 according to a constant-speed ratio.It is not required to by the way of V belt translation
It is lubricated, can be polluted in print procedure by lubricating oil to avoid biological tubular tissue, so as to ensure artificial bio-membrane
The safety that tubular tissue uses.Gear drive or chain can also used to pass in the case of isolation lubricating oil pollution
Dynamic mode.
For the power delivery mode in the embodiment, with reference to figure 3, the first swivel adapter is as drive end, the second rotation
Turn adapter as driven end, the first bearing 17 for being arranged on drive end is adjusted with being arranged on the second bearing 23 of driven end in installation
To ensure that two nutrient solution delivery sections 19 being mounted thereon are coaxial in examination, to ensure that bounce of the swingle in rotary course is use up
It measures small.Further, the first swivel adapter is installed on by two bearings 18 on the first bearing 17, so that support force is more
Stablize, and pass through end cap 16 and nutrient solution delivery section 19 and carry out thrust in both sides.The connection mode of driven end and drive end can adopt
With identical form, can be adjusted according to demand in structure.In order to reach preferable support stiffness, preferably by first
17 and second bearing 23 of seat is located at the outside of two nutrient solution delivery sections 19, so that end of the supporting point close proximity to axis.And
It is all in the printer to be installed on same installing plate 1 with the relevant component of swingle, the stabilization of overall performance can be improved
Property.
In order to make those skilled in the art be well understood cavity active mass of the present invention printer operation principle, under
Face will combine Fig. 1 to specific embodiment shown in Fig. 3, its course of work is described in detail.
Nutrient solution is fitted into nutrition liquid bath 11, temperature control temperature is set, opens simultaneously nutrient solution circulating pump, nutrient solution is from the
Four pipe fittings 8 enter the import of circulating pump, and the nutrient solution through being overpressurized enters the first pipe fitting 5 from the outlet of circulating pump again, from
And it flows into the conversion cavity 25 of the nutrient solution delivery section 19 of drive end, and full of conversion cavity 25, then connect by nutrient solution supply
Mouth 14 enters the hollow portion of the first swivel adapter, and then flow to the inside of hollow pipeline section 22, and nutrient solution can be by hollow pipeline section
Permeability hole 26 on 22 tube walls oozes out outward, does not continue to run to the nutrition of driven end from permeability hole 26 to the nutrient solution of exosmosis
Liquid delivery section, by with flow into the opposite method of process, flow out to the second pipe fitting 6, the second pipe fitting 6 on nutrition liquid bath 11
Third pipe fitting 7 be connected, suitable temperature is kept in nutrition liquid bath 11 so as to return to nutrient solution, is recycled according to this.Certainly,
It can also select that nutrient solution is made to enter to flow out from the first pipe fitting 5 by the second pipe fitting 6, at this time the conveying direction of circulating pump
It is also required to correspondingly switch over.
By detecting temperature and circulation time at external circulating-pump outlet, nutrient solution in current swingle can be speculated
Whether set temperature is reached.When the set temperature is reached, servo motor 2 under control of the control system, is controlled by synchronous pulley 3
Swingle rotation processed, so as to the printing head Union Movement with outside, the required cavity body structure of spiralization on swingle,
During printing, nutrient solution is oozed out from the permeability hole 26 of swingle for cells with nutrient.In addition, the present invention also provides
A kind of biometric print machine, including the print module described in above-described embodiment, which can spray with the printing on printer
Head matches the printing so as to fulfill biological tubular tissue or other cavity active mass.When in use, by print module water
Safety fills, and forming 90 degree with printing head places, it can be achieved that the printing of lateral biological tubular tissue.Such biometric print machine due to
Employ the print module of convenient disassembly, it is thus possible to improve the convenience that printer uses, and shorten the time-write interval；And by
In cells with nutrient liquid can be given in print procedure so that the biological tubular tissue or other cavitys that such printer makes
Active mass can keep higher activity and longer service life.
A kind of biometric print machine print module provided by the present invention and biometric print machine are described in detail above.
Specific embodiment used herein is expounded the principle of the present invention and embodiment, and the explanation of above example is only
It is the method and its core concept for being used to help understand the present invention.It should be pointed out that for those skilled in the art
For, without departing from the principle of the present invention, can also to the present invention some improvement and modification can also be carried out, these improve and repair
Decorations are also fallen within the protection scope of the claims of the present invention.
Claims (14)
1. a kind of biometric print machine print module, which is characterized in that including：Support member and equipped with nutrient solution supply interface (14)
Swingle, the swingle is rotatably supported in the support member, and the surface of the swingle prints for receiving
The biological prepared Chinese ink that nozzle provides, the swingle include the hollow pipeline section (22) with center through hole, and hollow pipeline section (22)
Tube wall is equipped with the permeability hole (26) connected with the center through hole, the center of the nutrient solution supply interface and the swingle
Through-hole connects external nutrient solution importing the swingle；
The support member includes support portion and nutrient solution delivery section (19), and the nutrient solution supply interface (14) is located at the rotation
On the circumferencial direction of bull stick, the swingle is rotatably supported on the support portion, nutrient solution delivery section (19) set
It is located on the swingle and there is delivery section interface, be equipped in the nutrient solution delivery section (19) and the delivery section interface connects
Logical, to surround the swingle in a circumferential direction conversion cavity (25), the nutrient solution are supplied described in interface (14) connection
Center through hole and the conversion cavity (25).
2. biometric print machine print module according to claim 1, which is characterized in that sealing device is further included, it is described close
Encapsulation is set between the nutrient solution delivery section (19) and the swingle.
3. biometric print machine print module according to claim 1, which is characterized in that further include for the swingle
The nutrition liquid bath (11) of nutrient solution is provided, the nutrition liquid bath (11) has slot interface, and the slot interface connects with the delivery section
Mouth is connected by nutrient solution conveying device, and the nutrient solution conveying device is used to control the nutrient solution in the nutrition liquid bath (11)
Into the swingle.
4. biometric print machine print module according to claim 3, which is characterized in that the nutrient solution conveying device is also used
In the flow velocity and flow of control nutrient solution；Or the biometric print machine print module further includes and the nutrient solution conveying device
The nutrient solution control device of series connection, the slot interface pass through the nutrient solution conveying device and the battalion with the delivery section interface
Nutrient solution control device connects, and the nutrient solution control device is used to control the flow velocity and flow of nutrient solution.
5. biometric print machine print module according to claim 3, which is characterized in that further include to detect nutrient solution temperature
The temperature detection part of degree or the nutrient solution temperature control device for controlling solution temperature.
6. biometric print machine print module according to claim 5, which is characterized in that the nutrient solution temperature control device packet
It includes：Semiconductor chilling plate (13), temperature controller and radiator, the semiconductor chilling plate (13) are set to the nutrient solution
The bottom of slot (11), for the nutrition liquid bath (11) to be heated or cooled under the control of the temperature controller, institute
Semiconductor chilling plate (13) is stated with temperature control end and non-temperature control end, the temperature control end is set towards the nutrition liquid bath (11), institute
Non- temperature control end is stated to set towards the radiator.
7. biometric print machine print module according to claim 6, which is characterized in that the nutrition liquid bath (11) with it is described
Heat-conducting plate or soaking plate are equipped between semiconductor chilling plate (13).
8. biometric print machine print module according to claim 1, which is characterized in that the swingle further includes group section
(15；24), the nutrient solution supply interface (14) is arranged on the group section (15；24) on, the group section (15；24) it is removable
Coaxially it is located at the end of the hollow pipeline section (22), the group section (15 with unloading；24) it is rotatably supported at the support portion
On part, the group section (15；24) it can be actuated to that the hollow pipeline section (22) is driven to rotate.
9. biometric print machine print module according to claim 8, which is characterized in that connector (21) is further included, it is described
Group section (15；24) it is connect by the connector (21) with the end of the hollow pipeline section (22).
10. biometric print machine print module according to claim 9, which is characterized in that the connector (21) is screw thread
Connector.
11. biometric print machine print module according to claim 8, which is characterized in that the group section (15；24) it is set in
There are the hollow portion connected with nutrient solution supply interface (14), the hollow portion and the center through hole of the hollow pipeline section (22)
It connects that nutrient solution is imported the hollow pipeline section (22) by the hollow portion.
12. biometric print machine print module according to claim 8, which is characterized in that the group section (15；24) and institute
State the end part seal connection of hollow pipeline section (22).
13. biometric print machine print module according to claim 1, which is characterized in that further include servo motor (2), institute
It states servo motor (2) to be arranged in parallel with the swingle, the servo motor (2) passes through synchronous pulley (3) with the swingle
With synchronous band connection.
14. a kind of biometric print machine, which is characterized in that including print module described in claim 1.
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| CN201511025784.4A CN105647803B (en) | 2015-12-30 | 2015-12-30 | Biometric print machine print module and biometric print machine |
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| CN201511025784.4A CN105647803B (en) | 2015-12-30 | 2015-12-30 | Biometric print machine print module and biometric print machine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017113156A1 (en) * | 2015-12-30 | 2017-07-06 | 四川蓝光英诺生物科技股份有限公司 | Printing module for biological printer, and biological printer |
| CN107432777A (en) * | 2016-08-31 | 2017-12-05 | 四川蓝光英诺生物科技股份有限公司 | The assembly and disassembly methods of rotational supporting structure, biometric print platform and its rotating rod structure |
| CN108673887B (en) * | 2018-06-14 | 2023-06-09 | 浙江大学 | Extensible human body fixing device for biological 3D printer |
| CN110669754A (en) * | 2019-10-29 | 2020-01-10 | 华侨大学 | Method for 3D printing of xylanase catalyst and application thereof |
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| CN104873300A (en) * | 2015-05-11 | 2015-09-02 | 浙江大学 | Apparatus for printing three dimensional biological structure having built-in nutrition channels |
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| CN204734579U (en) * | 2015-04-24 | 2015-11-04 | 周惠兴 | A make platform system for 3D blood vessel is printed |
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| US6513897B2 (en) * | 2000-12-29 | 2003-02-04 | 3M Innovative Properties Co. | Multiple resolution fluid applicator and method |
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| CN103120521A (en) * | 2013-03-15 | 2013-05-29 | 苏州卫生职业技术学院 | Combined-type semiconductor cold and hot vacuum cup |
| CN104146794A (en) * | 2014-08-24 | 2014-11-19 | 周惠兴 | Blood vessel forming device and method for 3D bioprinting |
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