CN205295361U - Bio -printer print module and bio -printer - Google Patents

Abstract

The utility model relates to a bio -printer print module and bio -printer, print module includes: the support component, motor (2) and be equipped with the rotary rod of nutrient solution supply interface (14), the rotary rod rotationally supports on the support component, and can be rotatory in order to realize by motor (2) drive, the surface of rotary rod is used for receiving the biological chinese ink of printing the shower nozzle and providing, the rotary rod is including cavity pipeline section (22) that have central through -hole, and be equipped with permeability hole (26) with central through -hole intercommunication on the pipe wall of cavity pipeline section (22), nutrient solution supply interface channels into the rotary rod with the central through -hole intercommunication of rotary rod with the nutrient solution with the outside. The utility model discloses a bio -printer print module can ooze out in order to supply with cell and the biological tubulose tissue on the rotary rod from the permeability hole printing inside the nutrient solution of in -process with the external world pass through the leading -in rotary rod of nutrient solution supply interface again to improve the survival rate and the biological function of cell.

Description

Biometric print machine print module and biometric print machine

Technical field

This utility model relates to biometric print technical field, particularly relates to a kind of biometric print machine print module and biometric print machine.

Background technology

Biological 3D prints and refers to by the 3D principle printed and method, biomaterial (including natural biologic material, synthesising biological material or cell solution) is printed the three-dimensional structure becoming design, it is different from common 3D printing technique, biological tissue or organ that biological 3D printing technique produces also have certain biological function, the further growth being required to be cell and tissue provides condition, just because of above-mentioned characteristic, biological 3D printing technique, in development, is faced with a lot of specific technical problem.

Wherein, field is printed at biological 3D, cell is called cell 3D printing technique as the technology of printed material, people can utilize cell and biocompatible materials to make biological prepared Chinese ink, make shower nozzle move and biology prepared Chinese ink is sprayed, moved by programme-control shower nozzle, by biological prepared Chinese ink according to default target print, with the three-dimensional digital model printing shaping according to object. In the medical field, the method that conventional biological 3D prints makes cavity active mass such as artificial blood vessel, and this provides approach for treating a lot of blood vessel kind diseases.

For printing the printer of blood vessel in prior art, including swingle and printing head, shape of blood vessel and size that the length of swingle and size print as required are designed, one end of swingle is supported by support and is driven by motor, the other end is unsettled, printing head is positioned at above swingle, and can move relative to the surface of swingle. During work printing head by biological ink jet to the surface of swingle to form biological vascular tissue, after printing, swingle with vascular tissue is taken off and puts into bio-incubator, add various somatomedin and short differentiation factor, accelerate vascular tissue's structure and various physiological function is reached maturity, obtain the blood vessel needed.

But this kind of scheme after cell is ejected on swingle and forms biological vascular tissue by printing head until whole print procedure terminate during this period of time in, it is positioned at the cell on swingle and biological vascular tissue lacks external nourishment supply, its cell survival and biological function and realizes all being subjected to impact. Visible, biological 3D is printed, nutrition supply is requisite important step, and how to provide nutritional solution to the carrier on dynamic swingle, then be always up the insoluble technical barrier in this area.

Utility model content

The purpose of this utility model is to propose a kind of biometric print machine print module and biometric print machine, it is possible to by the cell on extraneous nutritional solution supply swingle and biological tubular tissue in print procedure.

For achieving the above object, this utility model first aspect provides a kind of biometric print machine print module, including: support parts, motor and the swingle being provided with nutritional solution supply interface, described swingle is rotatably supported on described support parts, and can be driven to realize rotating by described motor, the surface of described swingle is for receiving the biological prepared Chinese ink that printing head provides, described swingle includes the hollow pipeline section with center through hole, and the tube wall of hollow pipeline section is provided with the permeability hole connected with described center through hole, described nutritional solution supply interface connects with the center through hole of described swingle outside nutritional solution is imported described swingle.

Further, described support parts include support portion and nutritional solution delivery section, described nutritional solution supply interface is located on the circumferencial direction of described swingle, described swingle is rotatably supported on described support portion, described nutritional solution delivery section is set on described swingle and has delivery section interface, it is provided with in described nutritional solution delivery section and described delivery section orifice, the conversion cavity that surrounds described swingle in a circumferential direction, center through hole and described conversion cavity described in described nutritional solution supply orifice.

Further, also including sealing device, described sealing device is located between described nutritional solution delivery section and described swingle.

Further, also include the nutrition liquid bath for providing nutritional solution to described swingle, described nutrition liquid bath has groove interface, described groove interface is connected by nutritional solution conveyer device with described delivery section interface, and described nutritional solution conveyer device enters described swingle for controlling the nutritional solution in described nutrition liquid bath.

Further, described nutritional solution conveyer device is additionally operable to control flow velocity and the flow of nutritional solution; Or the nutritional solution that described biometric print machine print module also includes connecting with described nutritional solution conveyer device controls device, described groove interface controls device with described delivery section interface by nutritional solution conveyer device and described nutritional solution and is connected, and described nutritional solution controls device for controlling flow velocity and the flow of nutritional solution.

Further, the temperature detection part for detecting solution temperature is also included or for controlling the nutritional solution attemperating unit of solution temperature.

Further, described nutritional solution attemperating unit includes: semiconductor chilling plate, temperature controller and heat abstractor, described semiconductor chilling plate is arranged at the bottom of described nutrition liquid bath, for described nutrition liquid bath being heated or cools down under the control of described temperature controller, described semiconductor chilling plate has temperature control end and non-temperature control end, described temperature control end is arranged towards described nutrition liquid bath, and described non-temperature control end is arranged towards described heat abstractor.

Further, it is provided with heat-conducting plate or soaking plate between described nutrition liquid bath and described semiconductor chilling plate.

Further, described swingle also includes group section, described nutritional solution supply interface is arranged on described group section, described group section is removably coaxially located at the end of described hollow pipeline section, described group section is rotatably supported on described support parts, and described group section can be actuated to drive described hollow pipeline section to rotate.

Further, also including adapter, described group section is connected by the end of described adapter with described hollow pipeline section.

Further, described adapter is screw thread coupling.

Further, being provided with and the hollow bulb of described nutritional solution supply orifice in described group section, described hollow bulb connects with the center through hole of described hollow pipeline section, by described hollow bulb, nutritional solution imports described hollow pipeline section.

Further, described group section is connected with the end seal of described hollow pipeline section.

Further, described motor is servomotor, and described servomotor and described swingle are arranged in parallel.

For achieving the above object, this utility model second aspect provides a kind of biometric print machine, including the print module described in above-described embodiment.

Based on technique scheme; biometric print machine print module of the present utility model; by arranging nutritional solution supply interface and permeability hole on swingle; can in print procedure, extraneous nutritional solution be imported inside swingle by nutritional solution supply interface; the cell and the biological tubular tissue that supply swingle is oozed out again from permeability hole; thus cell and biological tubular organization formation are protected, and then improve survival rate and the biological function of cell.

Accompanying drawing explanation

Accompanying drawing described herein is used for providing being further appreciated by of the present utility model, constitutes the part of the application, and schematic description and description of the present utility model is used for explaining this utility model, is not intended that improper restriction of the present utility model. In the accompanying drawings:

The three dimensional structure schematic diagram of one embodiment of Fig. 1 this utility model biometric print machine print module;

Fig. 2 is the top view of biometric print machine print module shown in Fig. 1;

Fig. 3 is the A-A sectional view of biometric print machine print module shown in Fig. 2;

Fig. 4 is the partial enlarged drawing B of biometric print machine print module shown in Fig. 2.

Description of reference numerals

1-installing plate; 2-servomotor; 3-synchronous pulley; 4-tension-regulator; 5-the first pipe joint; 6-the second pipe joint; 7-the 3rd pipe joint; 8-the 4th pipe joint; 9-the 5th pipe joint; 10-the 6th pipe joint; 11-nutrition liquid bath; 12-cooled plate; 13-semiconductor chilling plate; 14-nutritional solution supply interface; 15-group section; 16-end cap; 17-the first bearing; 18-bearing; 19-nutritional solution delivery section; 20-sealing ring; 21-adapter; 22-hollow pipeline section; 23-the second bearing; 24-group section; 25-changes cavity; 26-permeability hole.

Detailed description of the invention

This utility model described further below. In the following paragraphs, the different aspect of embodiment is defined in more detail. The each side so limited can combine with any other a aspect or many aspects, not can be combined unless explicitly stated otherwise. Especially, it is believed that be preferred or favourable any feature can one or more with other be considered as preferred or favourable feature.

The term descriptions merely for convenience such as " first ", " second " occurred in this utility model, to distinguish the different building blocks with same names, are not offered as successively or primary-slave relation.

In description of the present utility model; it will be appreciated that; term " on ", D score, "front", "rear", the orientation of the instruction such as " left side " and " right side " or position relationship be based on orientation shown in the drawings or position relationship; it is for only for ease of description this utility model; rather than the device of instruction or hint indication must have specific orientation, with specific azimuth configuration and operation, therefore it is not intended that restriction to this utility model protection domain.

This utility model provides a kind of biometric print machine print module, as shown in Figures 1 to 4, including: support parts, motor 2 and the swingle being provided with nutritional solution supply interface 14, swingle is rotatably supported on support parts, and can be driven to realize rotating by motor 2, the surface of swingle is for receiving the biological prepared Chinese ink that printing head provides, swingle includes the hollow pipeline section 22 with center through hole, and the tube wall of hollow pipeline section 22 is provided with the permeability hole 26 connected with center through hole, nutritional solution supply interface connects with the center through hole of swingle outside nutritional solution is imported swingle.

And, by regulating distribution and the size of permeability hole 26 on swingle, it is possible to adapt to the needs that the biological tubular tissue of different-thickness, length and character prints. Such as: biological tubular tissue can be blood vessel. It addition, nutritional solution is as required, it is possible to adopt disposable mode, it is possible to increase biological safety.

The biometric print machine print module of this utility model embodiment; can in print procedure, extraneous nutritional solution be imported inside swingle by nutritional solution supply interface 14; the cell and the biological tubular tissue that supply on swingle is oozed out again from permeability hole 26; thus cell and biological tubular organization formation are protected, and then improve survival rate and the biological function of cell.

Swingle in this embodiment can only include hollow pipeline section 22, or only it is provided with group section in one end of hollow pipeline section 22, the structure shown in Fig. 3 can also be taked, namely swingle includes hollow pipeline section 22 and is connected to group section 15 and the group section 24 at hollow pipeline section 22 two ends, group section 15 and group section 24 respectively the first swivel adapter and the second swivel adapter. Each embodiment given below all illustrates for the swingle forming structure shown in Fig. 3.

In order to be guided to the swingle rotated from fixed structure by nutritional solution, two kinds of lead-in mode at least can be adopted:

One, it is possible to from the end of swingle by carrying pipe to import nutritional solution, need the center through hole within swingle through vertically in this case and it needs to sound adapter is set in the junction of conveying pipe with swingle.

Its two, nutritional solution supply interface 14 be located on the circumferencial direction of swingle. Specifically, swingle includes hollow pipeline section 22 and is connected to group section 15 and the group section 24 at hollow pipeline section 22 two ends, group section 15 and group section 24 respectively the first swivel adapter and the second swivel adapter. Correspondingly, nutritional solution supply interface 14 is located on the circumferencial direction of the first swivel adapter and the second swivel adapter, two nutritional solution delivery section 19 are respectively sleeved on the first swivel adapter and the second swivel adapter and have delivery section interface, enlarged drawing B shown in Figure 4, it is provided with in nutritional solution delivery section 19 and delivery section orifice, the conversion cavity 25 that surrounds swingle in a circumferential direction, for the flowing of nutritional solution, nutritional solution supply interface 14 connects center through hole and conversion cavity 25.For a kind of concrete structure, conversion cavity 25 is offered along own axes at the interlude of nutritional solution delivery section 19 endoporus, and surrounds the swivel adapter of correspondence in a circumferential direction, it is preferable that change cavity 25 into cylindrical cavity.

In order to enable nutritional solution to supply, from nutritional solution, the center through hole that interface 14 flows into hollow pipeline section 22, first swivel adapter and the second swivel adapter are equipped with from the one end near hollow pipeline section 22 and supply, with nutritional solution, the hollow bulb that interface 14 connects, hollow bulb connects with the center through hole of hollow pipeline section 22, nutritional solution to import hollow pipeline section 22 by hollow bulb. Preferably, nutritional solution supply interface 14 is the hole radially offered on the outer wall of the first swivel adapter and the second swivel adapter.

Nutritional solution supply interface 14 is located at the embodiment on swingle circumferencial direction can make nutritional solution supply interface 14 all be immersed in the nutritional solution riddled in conversion cavity 25 at any time, solve nutritional solution and enter the technical barrier of motion structure from fixed structure, but also a part of nutritional solution can be stored in advance in conversion cavity 25, so that the supply of nutritional solution is more stable.

In this embodiment, support parts and can include support portion and nutritional solution delivery section 19, first swivel adapter and the second swivel adapter are rotatably supported on support portion, both independent structure had been can be designed as between support portion and nutritional solution delivery section 19, it is also designed to all-in-one-piece structure, here support portion is not limited along the position relationship of swingle axis with nutritional solution delivery section 19. In figure 3, support portion is respectively fixed on the first bearing 17 and the second bearing 23 on installing plate 1, first swivel adapter is supported by the first bearing 17 by bearing 18, second swivel adapter is supported by the second bearing 23 by bearing, the employing of bi-lateral support structure, improves the stability of rotation of swingle.

Further, in order to prevent nutritional solution from the clearance leakage between nutritional solution delivery section 19 and the first swivel adapter or the second swivel adapter, between nutritional solution delivery section 19 and the first swivel adapter, and between nutritional solution delivery section 19 and the second swivel adapter, sealing device is set, such as sealing ring 20, concretely O RunddichtringO. Preferably, it is respectively provided with at least one sealing ring 20 in the both sides of conversion cavity 25 and can reach good sealing effectiveness. The embodiment importing nutritional solution from the circumference of group section can make the setting of sealing ring be more prone to. And, also should be connected and sealed between the end of group section and hollow pipeline section 22.

In order to be biological tubular tissue with nutrient liquid in print procedure, biometric print machine print module also includes the nutrition liquid bath 11 for providing nutritional solution to swingle, and nutrition liquid bath 11 has groove interface. In one embodiment, groove interface is connected by nutritional solution conveyer device with delivery section interface, and nutritional solution conveyer device smoothly enters swingle for the nutritional solution controlled in nutrition liquid bath 11. Such as, pump can be set between groove interface and delivery section interface, to promote the flowing of nutritional solution. Further, nutritional solution conveyer device can also control flow velocity and the flow of nutritional solution, specifically can adopt the adjustable circulating pump of flow, for instance can be peristaltic pump or gear pump etc.

In another embodiment, the nutritional solution that biometric print machine print module also includes connecting with nutritional solution conveyer device controls device, groove interface controls device with delivery section interface by nutritional solution conveyer device and nutritional solution and is connected, and nutritional solution controls device for controlling flow velocity and the flow of nutritional solution. Such as, by circulating pump and flow control valve with the use of.

For both embodiments, in print procedure, by adjusting flow velocity and the flow of nutritional solution, it is also possible to indirectly regulate the temperature control capacity of swingle, print for high temperature or cooling and the heating of a large amount of printing provide the foundation.In the process that swingle rotates, can decide whether as required to open nutritional solution circulation.

A kind of concrete mode that each interface is set on nutrition liquid bath 11 and nutritional solution delivery section 19 presented below. As it is shown in figure 1, the delivery section interface in nutritional solution delivery section 19 includes: be located at the first pipe joint 5 in (with the direction of Fig. 3 for benchmark) the nutritional solution delivery section 19 of left side and be located at the second pipe joint 6 in the nutritional solution delivery section 19 of right side. Groove interface on nutrition liquid bath 11 includes: be located at the 3rd pipe joint 7 and the 4th pipe joint 8 on nutrition liquid bath 11. Circulating pump can be located between the first pipe joint 5 and the 4th pipe joint 8, or it is located between the second pipe joint 6 and the 3rd pipe joint 7, for promoting the flowing of nutritional solution, the flow path of nutritional solution, by describing when the operation principle of subsequent descriptions printer, wouldn't describe in detail here. Consider from the convenience of pipe-line layout and aesthetics, the 5th pipe joint 9 of first pipe joint the 5, second pipe joint the 6, the 3rd pipe joint the 7, the 4th pipe joint 8 and the side being arranged at cooled plate 12 and the 6th pipe joint 10 are arranged in the same side of printer.

In order to ensure the activity of biological cell in print procedure, it is provided that nutritional solution need to be maintained in certain temperature range, may be provided for for this detection solution temperature temperature detection part. In a kind of attainable embodiment, it is provided with temperature detection part at circulation delivery side of pump, for obtaining the outlet temperature of circulating pump, whether reaches the temperature needed in conjunction with the nutritional solution in the circulation time just energy comprehensive descision swingle of nutritional solution. It addition, temperature-detecting device can also be arranged in conversion cavity 25 or the position such as in nutrition liquid bath 11.

In an embodiment of the present utility model, printer also includes the nutritional solution attemperating unit for controlling solution temperature. As shown in Figure 3, nutritional solution attemperating unit includes: at least one semiconductor chilling plate 13, temperature controller and heat abstractor, at least one semiconductor chilling plate 13 is arranged at the outside of nutrition liquid bath 11, for being heated under the control of a temperature controller or cooling down. Multiple semiconductor chilling plate 13 is set and can effectively promote refrigeration or the power of heating, moreover it is possible to play the effect of redundancy backup. More preferably, between two adjacent semiconductor chilling plates 13, gap can be set, to facilitate semiconductor chilling plate 13 to install and wiring, wiring is placed in gap and can also play a protective role. Wherein, semiconductor chilling plate 13 has temperature control end and non-temperature control end, and temperature control end is arranged towards nutrition liquid bath 11, and to realize controlling the purpose of the solution temperature in the temperature of nutrition liquid bath 11 and then control nutrition liquid bath 11, non-temperature control end is arranged towards heat abstractor.

In concrete structural design, nutrition liquid bath 11 is positioned at the underface of swingle, and heat abstractor includes cooled plate 12, and semiconductor chilling plate 13 is located at below nutrition liquid bath 11, for passing through the change mode of operation of Automatic Program under the control of external temperature controller, including heating or refrigeration mode; Cooled plate 12 is located at the lower section of semiconductor chilling plate 13, and is fixed on installing plate 1, and for taking away the heat produced when semiconductor chilling plate 13 works, wherein, cooled plate 12 can also replace with other heat abstractor, for instance fan coolling etc.

In order to facilitate the fixing of semiconductor chilling plate 13, one heat-conducting plate being sized larger than cell body floor space of envisaged underneath or soaking plate at rectangle nutrition liquid bath 11, even heat that semiconductor chilling plate 13 produces can be transmitted to nutrition liquid bath 11 on the one hand, semiconductor chilling plate 13 can also be clipped between base and cooled plate 12 on the other hand, and by arranging bolt to realize and the fixing of cooled plate 12 in the surrounding of base.Polylith semiconductor chilling plate 13 can be arranged side by side. Such as owing to semiconductor chilling plate 13 is generally square, in order to rectangle nutrition liquid bath 11 is uniformly heated up, it is possible to adopt two block semiconductor cooling pieces 13 to be arranged side by side. As depicted in figs. 1 and 2, the side of cooled plate 12 is provided with the 5th pipe joint 9 and the 6th pipe joint 10,5th pipe joint 9 and the 6th pipe joint 10 connect water inlet and the outlet of external water-cooling circulating system respectively, are used for taking away the heat produced when semiconductor chilling plate 13 works.

When needs heat, temperature control system is in heated condition, and now the temperature control end of semiconductor chilling plate 13 is hot side, and passes to the nutritional solution in nutrition liquid bath 11 by adding thermogenetic heat, it is achieved the purpose that nutritional solution is heated up. Otherwise, when cooling is needed, the temperature control end of semiconductor chilling plate 13 becomes huyashi-chuuka (cold chinese-style noodles), absorb the heat of nutrition liquid bath 11 Middle nutrition liquid, it is achieved the purpose that nutritional solution is lowered the temperature, simultaneously, the non-temperature control end of quasiconductor becomes hot side, transfer heat to cooled plate 12, in order to reduce the temperature difference of semiconductor chilling plate 13 cold and hot surface, increase refrigeration.

Printer of the prior art there is also another drawback, and after printing, just swingle is required for when unloading pulling down the supporting construction of end together so that disassembly process is relatively complicated every time, and is difficult to ensure that the precision of installation every time is consistent; And when needing the biological tubular tissue printing different-diameter, it is necessary to it is replaced by the swingle of respective diameters so that supporting construction is also required to redesign, and makes the versatility of this printer and adaptability poor.

In order to solve this problem, in the embodiment that this utility model improves, swingle is except including hollow pipeline section 22, also include at least one group section (in Fig. 3 group section 15 and 24 respectively the first swivel adapter and the second swivel adapter), nutritional solution supply interface 14 is arranged on group section 15 and 24, group section is removably coaxially located at the end of hollow pipeline section 22, and it is rotatably supported on support parts, can be actuated to drive hollow pipeline section 22 to rotate, thus coordinate the printing realizing biological tubular tissue or other cavity active mass with printing head.

The biometric print machine print module of this embodiment, by swingle being designed as the dismountable structure of segmentation, and by supporting parts, group section is supported, avoid the structure directly end of swingle being supported in prior art, easily swingle can be pulled down after biological tubular tissue prints, support parts need not be dismantled, equally swingle also can be conveniently installed when next time prints, make handling comparatively convenient, such that it is able to save the time-write interval, and it is easily guaranteed that the installation accuracy of printer. It addition, when needing the biological tubular tissue printing different-diameter, the interface of hollow pipeline section and group section only need to be provided for simple replacement of, can change the swingle of different size easily to print different biological tubular tissues.

In a kind of version, only with a group section, this group section is connected to one end of hollow pipeline section, the other end is unsettled, when needs dismount swingle, it is only necessary to disconnect or connect hollow pipeline section and group section interface section between the two, being not related to the dismounting of supporting construction.

In another kind of version, adopt two group sections, in the embodiment shown in fig. 3, group section 15 is the first swivel adapter, group section 24 is the second swivel adapter, removably coaxially it is located at the two ends of hollow pipeline section 22 respectively, support parts two group sections are supported, thus indirectly realizing the support to swingle, drive one of them group section or simultaneously drive two group sections hollow pipeline section 22 just can be driven to rotate, thus with printing head at X, three at least one of motions in direction of Y and Z match, the biological prepared Chinese ink that printing head sprays is made to be attached to the outer surface of hollow pipeline section 22 according to predetermined track, thus realizing the printing of biological tubular tissue.

For adopting the embodiment of two group sections, with swingle for matrix when being organized in printing due to biological tubular, and swingle adopts the form that two ends support, can so that rotating comparatively steady, thus when printing longer biological tubular tissue, it is obtained in that higher precision, reduces making swingle deform due to action of gravity as far as possible, thus affecting the movement locus that biological prepared Chinese ink is preset. After printing, can be separated to realize dismounting by hollow pipeline section 22 and group section, and put into bio-incubator, add various somatomedin and short differentiation factor, accelerate biological tubular organizational structure and various physiological function is reached maturity, to obtain the biological tubular tissue needed. When needs print again, then the hollow pipeline section 22 corresponding with biological tubular tissue diameter is installed on group section.

Following various embodiments will print to example and illustrate adopting the printer of two group sections to realize biological tubular tissue.

In order to realize removably connecting between hollow pipeline section 22 and group section, in a kind of way of realization, referring to Fig. 3, this printer also includes two adapters 21, the first swivel adapter and the second swivel adapter and is connected to the two ends of hollow pipeline section 22 respectively through an adapter 21. Preferably, adapter 21 is screw thread coupling, namely on adapter 21, screwed hole is offered, axial two sections of screwed hole adapt with the diameter of swivel adapter and hollow pipeline section 22 respectively, and the axial length of the screwed hole coordinated with swivel adapter or the screwed hole mesoporous smaller coordinated with hollow pipeline section 22 is provided with surplus; And external screw thread is set at the linkage section of the first swivel adapter and the second swivel adapter with hollow pipeline section 22, can realize removably connecting by the cooperation of internal and external threads.

When biological tubular tissue print complete need to pull down hollow pipeline section 22 time, only need to rotate two adapters 21, such as, the axial length at the screwed hole coordinated with swivel adapter makes two adapters 21 move to two ends respectively when being provided with surplus, can be pulled down by hollow pipeline section 22; When needs print biological tubular tissue, hollow pipeline section 22 is docked between the first swivel adapter and the second swivel adapter, rotate two adapters 21 again, such as, axial length at the screwed hole coordinated with swivel adapter makes two adapters 21 move to centre respectively when being provided with surplus, the installation of hollow pipeline section 22 can be realized, after being locked by screw thread coupling, it is possible to outside rotary power is transferred to hollow pipeline section 22 by the first swivel adapter or the second swivel adapter. Can be seen that, the mode adopting screw thread coupling makes dismounting more convenient, will not relate to the supporting construction at two ends, it is thus possible to ensure the installation accuracy of printer, after guaranteeing that hollow pipeline section 22 installs, beating during rotation meets the requirements, and then makes the track that biological prepared Chinese ink is formed on swingle surface more accurate, and the arrangement to ensure artificial biological tubular organization internal structure more meets demand.

It addition, hollow pipeline section 22 according to the purposes printing different size biological tubular tissue, can select the diameter different specification from 1.5mm to 10mm. Simultaneously, a series of and biological tubular tissue diameter compatible set screw thread coupling can also be made, when printing the biological tubular tissue of different-diameter, can on the basis of this printer, only change hollow pipeline section 22 and screw thread coupling can realize, need not need to change the design of supporting construction as structure of the prior art, thus improve the versatility of printer and using motility.

Except adopting screw thread coupling, those skilled in the art can also adopt the structure of buckle or clip or ring flange type to realize removably connecting.

In another kind of way of realization, the end of hollow pipeline section 22 and group section is directly connected to. Here citing is provided several version that can be for reference. One, if only with a group section, then can design, with hollow pipeline section, the structure being directly connected to by screw thread by group section. They are two years old, according to two group sections, chute can be radially offered near one end of hollow pipeline section at the first swivel adapter and the second swivel adapter, chute extends to the axial line place of swingle, and the two ends of hollow pipeline section are equipped with the over-hang part suitable with chute, only need when mounted to embed from the open end of chute by over-hang part, be then fixed again through bearing pin or other securing member.

For the various embodiments described above, in order to avoid nutritional solution to leak in course of conveying as far as possible, it is desirable to the end seal of group section with hollow pipeline section 22 is connected. For being threaded connection the embodiment that the first swivel adapter and the second swivel adapter are connected by device with hollow pipeline section 22, after screw thread coupling is screwed, i.e. gap between salable two swivel adapters and hollow pipeline section 22, and rotary power is transferred to hollow pipeline section 22.

In further embodiment of the present utility model, printer drives swingle by servomotor 2, servomotor 2 under control of the control system, and outside printing head associated movement, cavity body structure required for spiralization on hollow pipeline section 22. The employing of servomotor 2 can comparatively accurately control the rotating speed of swingle, thus improving the ability that swingle carries out position control, and then can control to carry out associated movement with printing head.

In a preferred embodiment, in order to save space, top view as shown in Figure 2, servomotor 2 and swingle are arranged in parallel on installing plate 1, servomotor 2 is connected by synchronous pulley 3 and Timing Belt with the first swivel adapter, for the power of servomotor 2 is transferred to the first swivel adapter, the mode of V belt translation is beneficial to integral arrangement. Wherein, servomotor 2 is connected with the drivewheel of synchronous pulley 3, and the first swivel adapter is connected with the driven pulley of synchronous pulley 3, for instance: the modes such as key connection or securing member connection can be adopted. Synchronous pulley 3 carrys out tension adjusting by tension-regulator 4, and such servomotor 2 just comparatively can carry out position control exactly by synchronous pulley 3 according to a constant-speed ratio. The mode adopting V belt translation is made without lubrication, it is possible to avoid biological tubular to be organized in print procedure to be subject to the pollution of lubricating oil, thus ensureing the safety that artificial biological tubular tissue uses. When can isolation lubricating oil pollute, it would however also be possible to employ gear drive or chaindriven mode.

For the power delivery mode in this embodiment, with reference to Fig. 3, first swivel adapter is as drive end, second swivel adapter is as driven end, the first bearing 17 being arranged on drive end and the second bearing 23 being arranged on driven end to ensure that in installation and debugging two the nutritional solution delivery section 19 being mounted thereon are coaxial, as far as possible little to ensure swingle beating in rotary course. Further, the first swivel adapter is installed on the first bearing 17 by two bearings 18, so that support force is more stable, and carries out thrust in both sides by end cap 16 and nutritional solution delivery section 19.The connected mode of driven end and drive end can adopt identical form, structurally can be adjusted according to demand. In order to reach good support stiffness, it is desirable to the first bearing 17 and the second bearing 23 are located at the outside of two nutritional solution delivery section 19, so that the strong point is close proximity to the end of axle. And all assemblies relevant to swingle are installed on same installing plate 1 in this printer, it is possible to increase the stability of overall performance.

In order to make to understand with those skilled in the art know that the operation principle of the printer of this utility model cavity active mass, below in conjunction with the specific embodiment shown in Fig. 1 to Fig. 3, its work process is described in detail.

Nutritional solution is loaded in nutrition liquid bath 11, temperature control temperature is set, open nutritional solution circulating pump simultaneously, nutritional solution enters the import of circulating pump from the 4th pipe joint 8, nutritional solution through pressurization enters the first pipe joint 5 from circulation delivery side of pump again, thus flowing in the conversion cavity 25 of the nutritional solution delivery section 19 of drive end, and it is full of conversion cavity 25, the hollow bulb that interface 14 enters the first swivel adapter is supplied again by nutritional solution, and then it flow to the inside of hollow pipeline section 22, nutritional solution outwards can be oozed out by the permeability hole 26 on hollow pipeline section 22 tube wall, the nutritional solution delivery section of driven end is not continued to run to from permeability hole 26 to the nutritional solution of exosmosis, through the method contrary with the process of inflow, flow out to the second pipe joint 6, second pipe joint 6 is connected with the 3rd pipe joint 7 on nutrition liquid bath 11, so that nutritional solution returns to the temperature keeping suitable in nutrition liquid bath 11, circulate according to this. it is of course also possible to select to make nutritional solution be entered by the second pipe joint 6 and flow out from the first pipe joint 5, now the conveying direction of circulating pump is also required to correspondingly switch over.

By detecting temperature and the circulation time at external circulating-pump outlet place, it is possible to speculate in current swingle, whether nutritional solution reaches design temperature. When the set temperature is reached, servomotor 2 is under control of the control system, control swingle by synchronous pulley 3 to rotate, thus with outside printing head associated movement, cavity body structure required for spiralization on swingle, in the process printed, nutritional solution oozes out for cells with nutrient from the permeability hole 26 of swingle. It addition, this utility model additionally provides a kind of biometric print machine, including the print module described in above-described embodiment, this print module can match with the printing head on printer thus realizing biological tubular tissue or the printing of other cavity active mass. In use, print module level is installed, constitute 90 degree with printing head and lay, it may be achieved the printing of horizontal biological tubular tissue. This kind of biometric print machine is owing to have employed the print module of convenient disassembly, it is thus possible to improves the convenience that printer uses, and shortens the time-write interval; And owing to cells with nutrient liquid can be given in print procedure so that the biological tubular tissue of this kind of printer making or other cavity active mass can keep the higher active and longer life-span.

Above a kind of biometric print machine print module provided by the utility model and biometric print machine are described in detail. Principle of the present utility model and embodiment are set forth by specific embodiment used herein, and the explanation of above example is only intended to help to understand method of the present utility model and core concept thereof. Should be understood that; for those skilled in the art; under the premise without departing from this utility model principle, it is also possible to this utility model carries out some improvement and modification, these improve and modification also falls in this utility model scope of the claims.

Claims (15)

1. a biometric print machine print module, it is characterized in that, including: support parts, motor (2) and be provided with nutritional solution supply interface (14) swingle, described swingle is rotatably supported on described support parts, and can be driven to realize rotating by described motor (2), the surface of described swingle is for receiving the biological prepared Chinese ink that printing head provides, described swingle includes the hollow pipeline section (22) with center through hole, and the tube wall of hollow pipeline section (22) is provided with the permeability hole (26) connected with described center through hole, described nutritional solution supply interface connects with the center through hole of described swingle outside nutritional solution is imported described swingle.

2. biometric print machine print module according to claim 1, it is characterized in that, described support parts include support portion and nutritional solution delivery section (19), described nutritional solution supply interface (14) is located on the circumferencial direction of described swingle, described swingle is rotatably supported on described support portion, described nutritional solution delivery section (19) is set on described swingle and has delivery section interface, it is provided with and described delivery section orifice in described nutritional solution delivery section (19), surround the conversion cavity (25) of described swingle in a circumferential direction, described nutritional solution supply interface (14) connects described center through hole and described conversion cavity (25).

3. biometric print machine print module according to claim 2, it is characterised in that also including sealing device, described sealing device is located between described nutritional solution delivery section (19) and described swingle.

4. biometric print machine print module according to claim 2, it is characterized in that, also include the nutrition liquid bath (11) for providing nutritional solution to described swingle, described nutrition liquid bath (11) has groove interface, described groove interface is connected by nutritional solution conveyer device with described delivery section interface, and the nutritional solution that described nutritional solution conveyer device is used for controlling in described nutrition liquid bath (11) enters described swingle.

5. biometric print machine print module according to claim 4, it is characterised in that described nutritional solution conveyer device is additionally operable to control flow velocity and the flow of nutritional solution; Or the nutritional solution that described biometric print machine print module also includes connecting with described nutritional solution conveyer device controls device, described groove interface controls device with described delivery section interface by described nutritional solution conveyer device and described nutritional solution and is connected, and described nutritional solution controls device for controlling flow velocity and the flow of nutritional solution.

6. biometric print machine print module according to claim 4, it is characterised in that also include the temperature detection part for detecting solution temperature or for controlling the nutritional solution attemperating unit of solution temperature.

7. biometric print machine print module according to claim 6, it is characterized in that, described nutritional solution attemperating unit includes: semiconductor chilling plate (13), temperature controller and heat abstractor, described semiconductor chilling plate (13) is arranged at the bottom of described nutrition liquid bath (11), for described nutrition liquid bath (11) being heated or cools down under the control of described temperature controller, described semiconductor chilling plate (13) has temperature control end and non-temperature control end, described temperature control end is arranged towards described nutrition liquid bath (11), described non-temperature control end is arranged towards described heat abstractor.

8. biometric print machine print module according to claim 7, it is characterised in that be provided with heat-conducting plate or soaking plate between described nutrition liquid bath (11) and described semiconductor chilling plate (13).

9. biometric print machine print module according to claim 1, it is characterised in that described swingle also includes group section (15; 24), described nutritional solution supply interface (14) is arranged on described group section (15; 24) on, described group section (15; 24) end of described hollow pipeline section (22), described group section (15 removably coaxially it are located at; 24) it is rotatably supported on described support parts, described group section (15; 24) can be actuated to drive described hollow pipeline section (22) to rotate.

10. biometric print machine print module according to claim 9, it is characterised in that also include adapter (21), described group section (15; 24) it is connected by the end of described adapter (21) with described hollow pipeline section (22).

11. biometric print machine print module according to claim 10, it is characterised in that described adapter (21) is screw thread coupling.

12. biometric print machine print module according to claim 9, it is characterised in that described group section (15; 24) being provided with in and supply interface (14) hollow bulb that connects with described nutritional solution, described hollow bulb connects with the center through hole of described hollow pipeline section (22), by described hollow bulb, nutritional solution imports described hollow pipeline section (22).

13. biometric print machine print module according to claim 9, it is characterised in that described group section (15; 24) it is connected with the end seal of described hollow pipeline section (22).

14. biometric print machine print module according to claim 1, it is characterised in that described motor (2) is servomotor, described servomotor and described swingle are arranged in parallel.

15. a biometric print machine, it is characterised in that include the print module described in claim 1.