CN105643839A - 用于制备微针芯片的模具及其制备方法 - Google Patents
用于制备微针芯片的模具及其制备方法 Download PDFInfo
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- CN105643839A CN105643839A CN201510998852.9A CN201510998852A CN105643839A CN 105643839 A CN105643839 A CN 105643839A CN 201510998852 A CN201510998852 A CN 201510998852A CN 105643839 A CN105643839 A CN 105643839A
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- 238000004519 manufacturing process Methods 0.000 title abstract description 9
- 239000007788 liquid Substances 0.000 claims abstract description 71
- 238000002360 preparation method Methods 0.000 claims abstract description 68
- 238000000034 method Methods 0.000 claims abstract description 23
- 238000013022 venting Methods 0.000 claims description 82
- 230000010412 perfusion Effects 0.000 claims description 22
- -1 polytetrafluoroethylene Polymers 0.000 claims description 21
- 238000007711 solidification Methods 0.000 claims description 20
- 230000008023 solidification Effects 0.000 claims description 20
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 12
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 12
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- 229920004935 Trevira® Polymers 0.000 claims description 10
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- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 6
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- 239000012467 final product Substances 0.000 claims description 4
- 238000004080 punching Methods 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 11
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- 239000012466 permeate Substances 0.000 abstract 1
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- 239000000243 solution Substances 0.000 description 24
- 239000000463 material Substances 0.000 description 18
- 210000001124 body fluid Anatomy 0.000 description 17
- 239000010839 body fluid Substances 0.000 description 17
- 229920002379 silicone rubber Polymers 0.000 description 11
- 230000002262 irrigation Effects 0.000 description 10
- 238000003973 irrigation Methods 0.000 description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 9
- 238000010586 diagram Methods 0.000 description 8
- 229910001369 Brass Inorganic materials 0.000 description 6
- 229930006000 Sucrose Natural products 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
- 239000010951 brass Substances 0.000 description 6
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- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 238000001354 calcination Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 2
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- 230000008961 swelling Effects 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 229910021543 Nickel dioxide Inorganic materials 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 239000008118 PEG 6000 Substances 0.000 description 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 238000001015 X-ray lithography Methods 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
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- 230000000975 bioactive effect Effects 0.000 description 1
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- 229940079593 drug Drugs 0.000 description 1
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- 238000005429 filling process Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000003837 high-temperature calcination Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000003698 laser cutting Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
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- 229910003445 palladium oxide Inorganic materials 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/10—Moulds or cores; Details thereof or accessories therefor with incorporated venting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Mechanical Engineering (AREA)
Abstract
Description
Claims (14)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510998852.9A CN105643839B (zh) | 2015-12-24 | 2015-12-24 | 用于制备微针芯片的模具及其制备方法 |
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CN201510998852.9A CN105643839B (zh) | 2015-12-24 | 2015-12-24 | 用于制备微针芯片的模具及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN105643839A true CN105643839A (zh) | 2016-06-08 |
CN105643839B CN105643839B (zh) | 2018-01-12 |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106426687A (zh) * | 2016-10-17 | 2017-02-22 | 中国科学院理化技术研究所 | 一种用于制作聚合物微针的设备 |
WO2017107417A1 (zh) * | 2015-12-24 | 2017-06-29 | 广州新济药业科技有限公司 | 微针芯片及其制备方法 |
CN110038215A (zh) * | 2019-04-28 | 2019-07-23 | 广州新济薇娜生物科技有限公司 | 可溶性微针芯片生产设备及其生产方法 |
CN111344131A (zh) * | 2017-11-15 | 2020-06-26 | 株式会社Lg生活健康 | 用于连续制造微针的装置和工艺 |
CN113580491A (zh) * | 2021-07-21 | 2021-11-02 | 优微(珠海)生物科技有限公司 | 可溶性微针的喷射制作设备及方法 |
CN114211699A (zh) * | 2021-11-10 | 2022-03-22 | 武汉南望环保技术研究有限责任公司 | 一种高分子微针的制备模具及制备方法 |
WO2023004787A1 (zh) * | 2021-07-28 | 2023-02-02 | 上海悦肤达生物科技有限公司 | 制备微针的设备及方法 |
CN115737531A (zh) * | 2022-11-29 | 2023-03-07 | 华中科技大学 | 一种双透微灌注法制备微针阵列的方法、微针阵列及应用 |
WO2023241213A1 (zh) * | 2022-06-15 | 2023-12-21 | 深圳青澜生物技术有限公司 | 一种分层式微针成型方法及分层式微针成型装置 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102202723A (zh) * | 2009-10-08 | 2011-09-28 | 株式会社培旺精廉宅 | 微针片材的压模及其制造方法和采用该压模的微针的制造方法 |
-
2015
- 2015-12-24 CN CN201510998852.9A patent/CN105643839B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102202723A (zh) * | 2009-10-08 | 2011-09-28 | 株式会社培旺精廉宅 | 微针片材的压模及其制造方法和采用该压模的微针的制造方法 |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11452853B2 (en) | 2015-12-24 | 2022-09-27 | Guangzhou Micnano Biotech Co., Ltd | Microneedle chip and manufacturing method thereof |
WO2017107417A1 (zh) * | 2015-12-24 | 2017-06-29 | 广州新济药业科技有限公司 | 微针芯片及其制备方法 |
CN106426687B (zh) * | 2016-10-17 | 2019-05-10 | 中科微针(北京)科技有限公司 | 一种用于制作聚合物微针的设备 |
CN106426687A (zh) * | 2016-10-17 | 2017-02-22 | 中国科学院理化技术研究所 | 一种用于制作聚合物微针的设备 |
CN111344131A (zh) * | 2017-11-15 | 2020-06-26 | 株式会社Lg生活健康 | 用于连续制造微针的装置和工艺 |
US11511463B2 (en) | 2017-11-15 | 2022-11-29 | Lg Household & Health Care Ltd. | Apparatus and process for continuously manufacturing microneedles |
CN110038215A (zh) * | 2019-04-28 | 2019-07-23 | 广州新济薇娜生物科技有限公司 | 可溶性微针芯片生产设备及其生产方法 |
CN113580491B (zh) * | 2021-07-21 | 2022-05-17 | 优微(珠海)生物科技有限公司 | 可溶性微针的喷射制作设备及方法 |
CN113580491A (zh) * | 2021-07-21 | 2021-11-02 | 优微(珠海)生物科技有限公司 | 可溶性微针的喷射制作设备及方法 |
WO2023004787A1 (zh) * | 2021-07-28 | 2023-02-02 | 上海悦肤达生物科技有限公司 | 制备微针的设备及方法 |
CN114211699A (zh) * | 2021-11-10 | 2022-03-22 | 武汉南望环保技术研究有限责任公司 | 一种高分子微针的制备模具及制备方法 |
WO2023241213A1 (zh) * | 2022-06-15 | 2023-12-21 | 深圳青澜生物技术有限公司 | 一种分层式微针成型方法及分层式微针成型装置 |
CN115737531A (zh) * | 2022-11-29 | 2023-03-07 | 华中科技大学 | 一种双透微灌注法制备微针阵列的方法、微针阵列及应用 |
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CN105643839B (zh) | 2018-01-12 |
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Effective date of registration: 20180302 Address after: 510006 Guangdong city of Guangzhou province Panyu District Xiaoguwei Street Outer Ring Road No. 280 Building Room 101, a department of Guangdong Pharmaceutical University Patentee after: GUANGZHOU XINJI WEINA BIOTECHNOLOGY CO.,LTD. Address before: 510660, room 262, No. 503, Zhongshan Avenue, Tianhe District, Guangdong, Guangzhou Patentee before: NEWORLD PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20200827 Address after: 510000 Room 101, No.1 building, Department of Guangdong Pharmaceutical College, no.280, Waihuan East Road, Xiaoguwei street, Panyu District, Guangzhou City, Guangdong Province Co-patentee after: GUANGZHOU XINJI WEINA BIOTECHNOLOGY Co.,Ltd. Patentee after: NEWORLD PHARMACEUTICAL Co.,Ltd. Address before: 510006 Guangdong city of Guangzhou province Panyu District Xiaoguwei Street Outer Ring Road No. 280 Building Room 101, a department of Guangdong Pharmaceutical University Patentee before: GUANGZHOU XINJI WEINA BIOTECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20231018 Address after: 510006 Room 501, floor 2, building 1, No. 1078, Xingye Avenue East, Hualong Town, Panyu District, Guangzhou, Guangdong Province Patentee after: NEWORLD PHARMACEUTICAL Co.,Ltd. Address before: 510000 Room 101, building 1, Guangdong Pharmaceutical College, 280 Waihuan East Road, Xiaoguwei street, Panyu District, Guangzhou City, Guangdong Province Patentee before: NEWORLD PHARMACEUTICAL Co.,Ltd. Patentee before: GUANGZHOU XINJI WEINA BIOTECHNOLOGY CO.,LTD. |