CN105641736A - Surgical suture with bactericidal and anti-inflammatory effects and preparation method thereof - Google Patents
Surgical suture with bactericidal and anti-inflammatory effects and preparation method thereof Download PDFInfo
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- CN105641736A CN105641736A CN201510946853.9A CN201510946853A CN105641736A CN 105641736 A CN105641736 A CN 105641736A CN 201510946853 A CN201510946853 A CN 201510946853A CN 105641736 A CN105641736 A CN 105641736A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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Abstract
The present invention discloses a surgical suture with bactericidal and anti-inflammatory effects. The surgical suture is mainly prepared from the following pharmaceutical raw materials by weight: 2-8 parts of semen firmianae, 9-15 parts of scarlet swertia herb, 6-15 parts of sivery aleuritopteris herb, 5-12 parts of honey-fried licorice root, 2-6 parts of marginate rockbell herb, 3-9 parts of Toricellia angulata Olinv., 2-6 parts of longan shell, 12-18 parts of common elsholtzia herb, 10-15 parts of oot of Axillaryflower Twistedstalk, 40-54 parts of polylactic acid, 20-24 parts of polyethylene glycol, and 8-12 parts of carboxymethyl chitosan. The traditional Chinese medicines contained in the surgical suture have the effects of detoxifying, clearing heat, astringing sores and engendering flesh; and the surgical suture has the advantages of cheap and easily available materials, low cost, good economic returns, infection resistance, good tissue compatibility, and cell growth promotion.
Description
Technical field
The present invention relates to field of medical materials, particularly relate to a kind of suture and the method for making thereof with bactericidal antiphlogistic effect.
Background technology
Operating sutures is conventional biological textiles, and extensively for all kinds of surgical operation, in order to sew up a wound, conjunctive tissue is extremely important medical material. Along with development that is biomedical and polymer material science, Degradable Biomedical Materials is just causing people to pay close attention to more and more widely. At pharmaceutical sanitary field, Degradable Biomedical Materials obtains to be developed energetically, it is widely used in body the fields such as suture line, " human tissue engineering " material, drug release carrier, surgery bonesetting material, especially has a extensive future in the form reparation and reconstruction of tendon, ligament. Poly(lactic acid) (PLA), taking the farm crop such as corn, cassava as raw material, through fermentable, extracts obtained lactic acid, then through refining, dewater oligomeric, Pintsch process, be polymerized. Poly(lactic acid) is a kind of good biocompatibility and can the polymkeric substance of biological degradation of having, final degraded product is carbonic acid gas and water, it is to human non-toxic, non-stimulated, and therefore polylactide and its copolymer has become in bio-medical material one of material of being paid attention to most. At present, polylactic acid material product at medical field extensively for drug controlled release carrier, organizational project, bone internal fixtion, reparation, operating sutures, artificial skin and three-dimensional porous rack etc.
Publication No. CN104368039A(application number 201410684311.4) Chinese patent literature disclose a kind of Medical absorbable suture line and its preparation method, this suture line comprises following component: Resomer X 210, poly(lactic acid), jellyfish collagen, chitosan, linking agent, stablizer and antiseptic-germicide. Publication No. CN105079868A(application number 201510492433.8) Chinese patent literature disclose a kind of good absorbable medical suture of consistency and its preparation method, its raw material comprises by weight: PGA 20-40 part, polydactyl acid 10-20 part, poly(lactic acid) 50-70 part, hyaluronic acid 10-20 part, methyl methacrylate 5-7 part, epoxy soybean oil 4-6 part, tea tree oil 2-4 part, polycaprolactone 1-5 part, calcium stearate 0.1-0.3 part. Publication No. CN104940986A(application number 201510308466.2) Chinese patent literature disclose a kind of be applicable in skin suture line and its preparation method, polypropylene 45-63 part, butyleneglycol 17-29 part, glycerine 9-18 part, maleic anhydride 5-21 part, primary ammonium phosphate 2-11 part, poly(lactic acid) 13-27 part, PGA 2-10 part, 2,6-tri-grades of butyl-4-methylphenol 4-18 parts.
Degradable Biomedical Materials has been widely used in the preparation of suture line, but the preparation method of some of them suture line still needs to improve, or made suture line is difficult to meet clinical needs, therefore still needs to strengthen the research of this aspect, develop the suture of a kind of better performances.
Summary of the invention
For the deficiencies in the prior art, it is an object of the invention to provide a kind of suture with bactericidal antiphlogistic effect and the method for making thereof of preparing simple, good biocompatibility.
The technical scheme of the present invention is:
The suture with bactericidal antiphlogistic effect, is prepared from primarily of following raw materials according, is mass parts: Semen Firmianae 2-8, Herba Swertiae Puniceae 9-15, Silvery Aleuritopteris 6-15, Radix Glycyrrhizae Preparata 5-12, Herba Wahlenbergiae 2-6, water wax gourd root 3-9, Pericarpium Longan 2-6, Herba Elsholtziae Ciliatae 12-18, bamboo grove clouds 10-15, poly(lactic acid) 40-54, polyoxyethylene glycol 20-24, cm-chitosan 8-12.
In preferred scheme, Semen Firmianae 2-8, Herba Swertiae Puniceae 9-15, Silvery Aleuritopteris 6-15, Radix Glycyrrhizae Preparata 5-12, Herba Wahlenbergiae 2-6, water wax gourd root 3-9, Pericarpium Longan 2-6, Herba Elsholtziae Ciliatae 12-18, bamboo grove clouds 10-15, poly(lactic acid) 45-49, polyoxyethylene glycol 21-23, cm-chitosan 9-11.
More preferably, Semen Firmianae 5, Herba Swertiae Puniceae 12, Silvery Aleuritopteris 10.5, Radix Glycyrrhizae Preparata 8.5, Herba Wahlenbergiae 4, water wax gourd root 6, Pericarpium Longan 4, Herba Elsholtziae Ciliatae 15, bamboo grove clouds 12.5, poly(lactic acid) 47, polyoxyethylene glycol 22, cm-chitosan 10.
The preparation method of the described suture with bactericidal antiphlogistic effect, step is:
(1) water wax gourd root and Herba Elsholtziae Ciliatae being cleaned, mix thoroughly with ginger juice, leave standstill 30 minutes, take out, be placed in frying pan, slow fire heats, and fries to surface tawny, takes out, dry in the air cool;
(2) getting Semen Firmianae is placed in frying pan, and slow fire is heated to surperficial micro-drum, takes out, and adds refining mulse dipping 10-18 minute, take out, dry together with the bamboo grove clouds of section;
(3) being laid in steaming tray by Radix Glycyrrhizae, be placed in pot Steam by water bath, after big fire is boiled, Herba Swertiae Puniceae is put into steaming tray, fire of larding speech with literary allusions takes out, dries after steaming;
(4) Silvery Aleuritopteris, Radix Glycyrrhizae Preparata, Herba Wahlenbergiae, Pericarpium Longan are cleaned, pulverize and sieve together with step (1) (2) (3) made raw material, add dehydrated alcohol lixiviate, extracting at constant temperature 6-8 hour (preferred, lixiviate 7 hours) at 40-60 DEG C, lixiviate twice, take out filter, merging filtrate, vacuum distilling recycling design, obtained thick cream;
(5) dissolve poly(lactic acid) with methylene dichloride and it is configured to the poly(lactic acid) solution that mass concentration is 10%, add the made thick cream of step (4), mix thoroughly, add polyoxyethylene glycol again and cm-chitosan fully stirs, ultrasonic concussion 40-70 minute, filter, disappear bubble, obtains spinning solution;
(6) wet spinning technology is adopted to carry out spinning made for step (5) spinning solution, peptizer is water, first stretch bath is 50 DEG C of warm water, second stretch bath is 100 DEG C of boiling water, the long filament weaved is cut off, with 40 DEG C of water washings, takes out, dry 60-100 minute (preferred, dry 70-90 minute; More preferably, dry 80 minutes), obtained acid fiber by polylactic, adds and is twisted into suture line, sterilising packaging, obtain suture line.
The preparation method of the described suture with bactericidal antiphlogistic effect, step (2) dipping 12-16 minute (preferred, to flood 14 minutes).
The preparation method of the described suture with bactericidal antiphlogistic effect, step (3) is larded speech with literary allusions, and fire within pan-fried 20-35 minute, (preferred, decoct 24-31 minute by fire of larding speech with literary allusions;More preferably, fire of larding speech with literary allusions is decocted 27 minutes).
The preparation method of the described suture with bactericidal antiphlogistic effect, step (4) dehydrated alcohol consumption is 4-6 times (preferred, dehydrated alcohol consumption is 5 times of institute's lixiviate raw materials quality) of institute's lixiviate raw materials quality.
The preparation method of the described suture with bactericidal antiphlogistic effect, step (4) extraction temperature is 45-55 DEG C (preferred, extraction temperature is 50 DEG C).
The preparation method of the described suture with bactericidal antiphlogistic effect, step (5) ultrasonic concussion 50-60 minute (preferred, ultrasonic concussion 55 minutes).
The preparation method of the described suture with bactericidal antiphlogistic effect, step (6) drying temperature is 55-75 DEG C, and (preferred, drying temperature is 60-70 DEG C; More preferably, drying temperature is 65 DEG C).
The suture preparation science with bactericidal antiphlogistic effect provided by the invention, method is simple, it is not necessary to take out stitches. In addition, the excellent results of the present invention also shows: traditional Chinese medicine ingredients contained by the present invention has the effects such as clearing heat and detoxicating, expelling pus and promoting granulation; Material therefor of the present invention is cheaply easy to get, and cost is low, good in economic efficiency; The anti-infection of the present invention, histocompatibility is good, can Promote cell's growth.
Embodiment
The technical scheme of the present invention is described in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
Embodiment 1 has the suture of bactericidal antiphlogistic effect, is prepared from (every part of 10g) primarily of following raw materials according: Semen Firmianae 2, Herba Swertiae Puniceae 9 parts, Silvery Aleuritopteris 6 parts, Radix Glycyrrhizae Preparata 5 parts, Herba Wahlenbergiae 2 parts, water wax gourd root 3 parts, Pericarpium Longan 2 parts, Herba Elsholtziae Ciliatae 12 parts, bamboo grove clouds 10 parts, poly(lactic acid) 40 parts, polyoxyethylene glycol 20 parts, cm-chitosan 8 parts.
The preparation method of the above-mentioned suture with bactericidal antiphlogistic effect is:
(1) water wax gourd root and Herba Elsholtziae Ciliatae being cleaned, mix thoroughly with ginger juice, leave standstill 30 minutes, take out, be placed in frying pan, slow fire heats, and fries to surface tawny, takes out, dry in the air cool;
(2) getting Semen Firmianae is placed in frying pan, and slow fire is heated to surperficial micro-drum, takes out, and adds refining mulse and floods 10 minutes, take out, dry together with the bamboo grove clouds of section;
(3) being laid in steaming tray by Radix Glycyrrhizae, be placed in pot Steam by water bath, after big fire is boiled, Herba Swertiae Puniceae is put into steaming tray, fire of larding speech with literary allusions takes out, dries after steaming 20 minutes;
(4) Silvery Aleuritopteris, Radix Glycyrrhizae Preparata, Herba Wahlenbergiae, Pericarpium Longan are cleaned, pulverize and sieve together with step (1) (2) (3) made raw material, add dehydrated alcohol lixiviate 4 times of institute's lixiviate raw materials quality (dehydrated alcohol consumption be), extracting at constant temperature 6 hours at 40 DEG C, lixiviate twice, takes out filter, merging filtrate, vacuum distilling recycling design, obtained thick cream;
(5) dissolving poly(lactic acid) with methylene dichloride and be configured to the poly(lactic acid) solution that mass concentration is 10%, add the made thick cream of step (4), mix thoroughly, then add polyoxyethylene glycol and cm-chitosan fully stirs, ultrasonic concussion 40 minutes, filter, disappear bubble, obtains spinning solution;
(6) wet spinning technology is adopted to carry out spinning made for step (5) spinning solution, peptizer is water, and first stretch bath is 50 DEG C of warm water, and second stretch bath is 100 DEG C of boiling water, the long filament weaved is cut off, with 40 DEG C of water washings, take out, 55 DEG C of dryings 60 minutes, obtained acid fiber by polylactic, add and it is twisted into suture line, sterilising packaging, obtain suture line.
Embodiment 2 has the suture of bactericidal antiphlogistic effect, is prepared from (every part of 10g) primarily of following raw materials according: Semen Firmianae 8, Herba Swertiae Puniceae 15 parts, Silvery Aleuritopteris 15 parts, Radix Glycyrrhizae Preparata 12 parts, Herba Wahlenbergiae 6 parts, water wax gourd root 9 parts, Pericarpium Longan 6 parts, Herba Elsholtziae Ciliatae 18 parts, bamboo grove clouds 15 parts, poly(lactic acid) 54 parts, polyoxyethylene glycol 24 parts, cm-chitosan 12 parts.
The preparation method of the suture with bactericidal antiphlogistic effect is:
(1) water wax gourd root and Herba Elsholtziae Ciliatae being cleaned, mix thoroughly with ginger juice, leave standstill 30 minutes, take out, be placed in frying pan, slow fire heats, and fries to surface tawny, takes out, dry in the air cool;
(2) getting Semen Firmianae is placed in frying pan, and slow fire is heated to surperficial micro-drum, takes out, and adds refining mulse and floods 18 minutes, take out, dry together with the bamboo grove clouds of section;
(3) being laid in steaming tray by Radix Glycyrrhizae, be placed in pot Steam by water bath, after big fire is boiled, Herba Swertiae Puniceae is put into steaming tray, fire of larding speech with literary allusions takes out, dries after steaming 35 minutes;
(4) Silvery Aleuritopteris, Radix Glycyrrhizae Preparata, Herba Wahlenbergiae, Pericarpium Longan are cleaned, pulverize and sieve together with step (1) (2) (3) made raw material, add dehydrated alcohol lixiviate 6 times of institute's lixiviate raw materials quality (dehydrated alcohol consumption be), extracting at constant temperature 8 hours at 60 DEG C, lixiviate twice, takes out filter, merging filtrate, vacuum distilling recycling design, obtained thick cream;
(5) dissolving poly(lactic acid) with methylene dichloride and be configured to the poly(lactic acid) solution that mass concentration is 10%, add the made thick cream of step (4), mix thoroughly, then add polyoxyethylene glycol and cm-chitosan fully stirs, ultrasonic concussion 70 minutes, filter, disappear bubble, obtains spinning solution;
(6) wet spinning technology is adopted to carry out spinning made for step (5) spinning solution, peptizer is water, and first stretch bath is 50 DEG C of warm water, and second stretch bath is 100 DEG C of boiling water, the long filament weaved is cut off, with 40 DEG C of water washings, take out, 75 DEG C of dryings 100 minutes, obtained acid fiber by polylactic, add and it is twisted into suture line, sterilising packaging, obtain suture line.
Typical case: xxx, female, 46 years old. before one month, suddenly sensation upper right abdomen persistence angina, it is radiated to right infrascapular area, with feeling sick, vomiting, receive difference, abdominal distension, face is yellow, examination in hospital, is it possible that levy the positive, gall-bladder has tenderness, it is diagnosed as acute cholecystitis, row acute cholecystitis art, the present embodiment gained is used to have the silk sutures of bactericidal antiphlogistic effect when sewing up the incision, 1 day patient after art, otch has mild pain, without obviously red and swollen, after art 2 days, otch mild pain, without infecting rejection symptom, observe one week without infecting, leave hospital, patient's wound heald with I stage after 27 days, and linear healing, scar is not obvious, follow up a case by regular visits to 3 months without complication, after 32 days, suture line starts degraded, absorb completely after 45 days.
Embodiment 3 has the suture of bactericidal antiphlogistic effect, is prepared from (every part of 10g) primarily of following raw materials according: Semen Firmianae 2 parts, Herba Swertiae Puniceae 9 parts, Silvery Aleuritopteris 6 parts, Radix Glycyrrhizae Preparata 5 parts, Herba Wahlenbergiae 2 parts, water wax gourd root 3 parts, Pericarpium Longan 2 parts, Herba Elsholtziae Ciliatae 12 parts, bamboo grove clouds 10 parts, poly(lactic acid) 45 parts, polyoxyethylene glycol 21 parts, cm-chitosan 9 parts.
The preparation method of the suture with bactericidal antiphlogistic effect is:
(1) water wax gourd root and Herba Elsholtziae Ciliatae being cleaned, mix thoroughly with ginger juice, leave standstill 30 minutes, take out, be placed in frying pan, slow fire heats, and fries to surface tawny, takes out, dry in the air cool;
(2) getting Semen Firmianae is placed in frying pan, and slow fire is heated to surperficial micro-drum, takes out, and adds refining mulse and floods 12 minutes, take out, dry together with the bamboo grove clouds of section;
(3) being laid in steaming tray by Radix Glycyrrhizae, be placed in pot Steam by water bath, after big fire is boiled, Herba Swertiae Puniceae is put into steaming tray, fire of larding speech with literary allusions takes out, dries after steaming 24 minutes;
(4) Silvery Aleuritopteris, Radix Glycyrrhizae Preparata, Herba Wahlenbergiae, Pericarpium Longan are cleaned, pulverize and sieve together with step (1) (2) (3) made raw material, add dehydrated alcohol lixiviate 4 times of institute's lixiviate raw materials quality (dehydrated alcohol consumption be), extracting at constant temperature 6 hours at 45 DEG C, lixiviate twice, takes out filter, merging filtrate, vacuum distilling recycling design, obtained thick cream;
(5) dissolving poly(lactic acid) with methylene dichloride and be configured to the poly(lactic acid) solution that mass concentration is 10%, add the made thick cream of step (4), mix thoroughly, then add polyoxyethylene glycol and cm-chitosan fully stirs, ultrasonic concussion 50 minutes, filter, disappear bubble, obtains spinning solution;
(6) wet spinning technology is adopted to carry out spinning made for step (5) spinning solution, peptizer is water, and first stretch bath is 50 DEG C of warm water, and second stretch bath is 100 DEG C of boiling water, the long filament weaved is cut off, with 40 DEG C of water washings, take out, 70 DEG C of dryings 90 minutes, obtained acid fiber by polylactic, add and it is twisted into suture line, sterilising packaging, obtain suture line.
Typical case: xxx, man, 56 years old. It is hospitalized for treatment because suffering from acute appendicitis, after row appendicectomy, leave hospital after taking out stitches, but art still feels the indistinct pain of bottom right abdomen, hurt like hell within the next few days, examination in hospital later six months, find that incision of abdominal wall has tunnel, then carrying out debridement surgical, excision sinus and infected tissue, adopt the present embodiment gained to have the silk sutures of bactericidal antiphlogistic effect during stitching. Patient's wound healing is good, red and swollen infection does not occur, and X ray examination sinus heals, and follows up a case by regular visits to and occurs without complication half a year.
Embodiment 4 has the suture of bactericidal antiphlogistic effect, is prepared from (every part of 10g) primarily of following raw materials according: Semen Firmianae 8 parts, Herba Swertiae Puniceae 15 parts, Silvery Aleuritopteris 15 parts, Radix Glycyrrhizae Preparata 12 parts, Herba Wahlenbergiae 6 parts, water wax gourd root 9 parts, Pericarpium Longan 6 parts, Herba Elsholtziae Ciliatae 18 parts, bamboo grove clouds 15 parts, poly(lactic acid) 49 parts, polyoxyethylene glycol 23 parts, cm-chitosan 11 parts.
The preparation method of the suture with bactericidal antiphlogistic effect is:
(1) water wax gourd root and Herba Elsholtziae Ciliatae being cleaned, mix thoroughly with ginger juice, leave standstill 30 minutes, take out, be placed in frying pan, slow fire heats, and fries to surface tawny, takes out, dry in the air cool;
(2) getting Semen Firmianae is placed in frying pan, and slow fire is heated to surperficial micro-drum, takes out, and adds refining mulse and floods 16 minutes, take out, dry together with the bamboo grove clouds of section;
(3) being laid in steaming tray by Radix Glycyrrhizae, be placed in pot Steam by water bath, after big fire is boiled, Herba Swertiae Puniceae is put into steaming tray, fire of larding speech with literary allusions takes out, dries after steaming 31 minutes;
(4) Silvery Aleuritopteris, Radix Glycyrrhizae Preparata, Herba Wahlenbergiae, Pericarpium Longan are cleaned, pulverize and sieve together with step (1) (2) (3) made raw material, add dehydrated alcohol lixiviate 6 times of institute's lixiviate raw materials quality (dehydrated alcohol consumption be), extracting at constant temperature 8 hours at 55 DEG C, lixiviate twice, takes out filter, merging filtrate, vacuum distilling recycling design, obtained thick cream;
(5) dissolving poly(lactic acid) with methylene dichloride and be configured to the poly(lactic acid) solution that mass concentration is 10%, add the made thick cream of step (4), mix thoroughly, then add polyoxyethylene glycol and cm-chitosan fully stirs, ultrasonic concussion 60 minutes, filter, disappear bubble, obtains spinning solution;
(6) wet spinning technology is adopted to carry out spinning made for step (5) spinning solution, peptizer is water, and first stretch bath is 50 DEG C of warm water, and second stretch bath is 100 DEG C of boiling water, the long filament weaved is cut off, with 40 DEG C of water washings, take out, 70 DEG C of dryings 90 minutes, obtained acid fiber by polylactic, add and it is twisted into suture line, sterilising packaging, obtain suture line.
Embodiment 5 has the suture of bactericidal antiphlogistic effect, is prepared from (every part of 10g) primarily of following raw materials according: Semen Firmianae 5 parts, Herba Swertiae Puniceae 12 parts, Silvery Aleuritopteris 10.5 parts, Radix Glycyrrhizae Preparata 8.5 parts, Herba Wahlenbergiae 4 parts, water wax gourd root 6 parts, Pericarpium Longan 4 parts, Herba Elsholtziae Ciliatae 15 parts, bamboo grove clouds 12.5 parts, poly(lactic acid) 47 parts, polyoxyethylene glycol 22 parts, cm-chitosan 10 parts.
The preparation method of the suture with bactericidal antiphlogistic effect is:
(1) water wax gourd root and Herba Elsholtziae Ciliatae being cleaned, mix thoroughly with ginger juice, leave standstill 30 minutes, take out, be placed in frying pan, slow fire heats, and fries to surface tawny, takes out, dry in the air cool;
(2) getting Semen Firmianae is placed in frying pan, and slow fire is heated to surperficial micro-drum, takes out, and adds refining mulse and floods 14 minutes, take out, dry together with the bamboo grove clouds of section;
(3) being laid in steaming tray by Radix Glycyrrhizae, be placed in pot Steam by water bath, after big fire is boiled, Herba Swertiae Puniceae is put into steaming tray, fire of larding speech with literary allusions takes out, dries after steaming 27 minutes;
(4) Silvery Aleuritopteris, Radix Glycyrrhizae Preparata, Herba Wahlenbergiae, Pericarpium Longan are cleaned, pulverize and sieve together with step (1) (2) (3) made raw material, add dehydrated alcohol lixiviate 5 times of institute's lixiviate raw materials quality (dehydrated alcohol consumption be), extracting at constant temperature 7 hours at 50 DEG C, lixiviate twice, takes out filter, merging filtrate, vacuum distilling recycling design, obtained thick cream;
(5) dissolving poly(lactic acid) with methylene dichloride and be configured to the poly(lactic acid) solution that mass concentration is 10%, add the made thick cream of step (4), mix thoroughly, then add polyoxyethylene glycol and cm-chitosan fully stirs, ultrasonic concussion 55 minutes, filter, disappear bubble, obtains spinning solution;
(6) wet spinning technology is adopted to carry out spinning made for step (5) spinning solution, peptizer is water, and first stretch bath is 50 DEG C of warm water, and second stretch bath is 100 DEG C of boiling water, the long filament weaved is cut off, with 40 DEG C of water washings, take out, 65 DEG C of dryings 80 minutes, obtained acid fiber by polylactic, add and it is twisted into suture line, sterilising packaging, obtain suture line.
The pharmacology of the present invention's main Chinese medicine material used is as follows:
Semen Firmianae: base is former: be the seed of Sterculiaceae plant Chinese parasol tree. Nature and flavor: sweet are flat. Gui Jing: enter the heart, lung, kidney three warp. Function cures mainly: pleasant, and stomach, helps digestion. Cure the wound food, stomachache, hernia, children's's aphtha.
Herba Swertiae Puniceae: base is former: be the full grass of gentianaceae plant Swertia punicea Hemsl.. Nature and flavor: bitter, cold in nature. Function cures mainly: clearing liver profit courage, clearing heat and detoxicating, profit is wet. Main acute icterohepatitis, cholecystitis, common cold due to wind-heat, toothache due to pathogenic wind-fire, swelling and pain in the throat, maldigestion, acute bacillary dysentery, urinary system infection, tinnitus is deaf, burn and scald.
Silvery Aleuritopteris: base is former: be the complete stool of sinopteris grevilleoides section plant Aleuritopteris argentea (Gmel.) Fee. Nature and flavor: pungent, sweet, flat. Gui Jing: lung, Liver Channel. Function cures mainly: expelling phlegm for arresting cough, promoting blood circulation to restore menstrual flow, and profit is wet, detoxify and promote the subsdence of swelling. Main cough, menoxenia, through closing stomachache, leucorrhea with red and white discharge, tuberculosis hemoptysis, stool diarrhea, difficulty and pain in micturition, lung carbuncle, acute mastitis, rheumatic arthritis, wound, intercostal neuralgia, epidemic hemorrhagic conjunctivitis, sore swells.
Radix Glycyrrhizae Preparata: get clean Radix Glycyrrhizae tabellae, adds cooked honey and a little boiling water, slightly vexed after mixing thoroughly, fries to yellow to deep yellow, takes out, dry in the air cool time tack-free.Nature and flavor: sweet are flat. Gui Jing: the thoughts of returning home, lung, spleen, stomach warp. Function cures mainly: tonifying spleen and stomach, Yiqi and vein recovery. For weakness of the spleen and the stomach, fatigue and weakness, severe palpitation, intermittent pulse.
Herba Wahlenbergiae: base is former: be root or the whole herb with root of Campanulaceae Herba Wahlenbergiae. Nature and flavor: property is put down, the sweet micro-hardship of taste. Gui Jing: enter spleen, the heart. Function cures mainly: qi-restoratives, induces sweat. Controlling deficient internal lesion caused by overexertion, hemoptysis, bleeding from five sense organs or subcutaneous tissue, spontaneous perspiration, night sweat, women leukorrhea, cough due to common cold, stomachache, rushes down dysentery, knife wound.
Water wax gourd root: base is former: be root or the root skin of skunk bush section plant angle leaf sheath handle wood. Nature and flavor: taste is pungent, micro-hardship, slightly warm in nature. Function cures mainly: dispel rheumatism, synthetism of invigorating blood circulation. Main rheumatic arthralgia, falls dozen stasis of blood and swells, fracture, amenorrhoea.
Pericarpium Longan: base is former: for without suffering from the pericarp of section plant longan. Nature and flavor: sweet, temperature. Gui Jing: lung channel. Function cures mainly: dispel the wind, removing toxic substances, sore, myogenic. Main dizzy deafness, ulcer is burst for a long time and is not held back, and scalds.
Herba Elsholtziae Ciliatae: base is former: be the full grass of labiate elscholtiza. Nature and flavor: hardship pungent, micro-, temperature. Function cures mainly: drive wind sweating, clearing away heat to stop bleeding, removing toxic substances.
Bamboo grove clouds: base is former: be the root and rhizome of the precious tongued bell grass of liliaceous plant or long stamen cantonese fairy bells. Nature and flavor: taste is sweet, light, property is put down. Function cures mainly: moisten the lung and relieve the cough, and strong gland helps digestion, and stimulates the circulation of the blood and cause the muscles and joints to relax, clearing heat and detoxicating. Main cough due to lung-heat, tuberculosis is spat blood, and it is full that dyspepsia is swollen, rheumatic arthralgia, pain in the waist and lower extremities, fracture, burn.
Test example 1 gained of the present invention has the anti-microbial property test of the suture (embodiment 5) of bactericidal antiphlogistic effect:
Test strain is streptococcus aureus and intestinal bacteria, testing method reference standard GB/T20944.1-2007 " the evaluation first part of antibacterial textile performance: agar plate diffusion process ". Concrete operation: suture cutting is become 5cm segment, it is placed in the nutrient agar central authorities scribbling bacterium liquid, experimental group adopts the made suture line of the present invention, control group adopts network gutstring, substratum is placed in 37 DEG C of constant incubators after process and cultivates 24h, after 24h, suture line is moved on new culture dish, until antibacterial band disappears, measure its Durability of antimicrobial effect, every 24h observes and measures the antibacterial band external diameter width of a suture line 5 different positionss, and test repeats 3 times, and result gets the mean value after calculating. Antibacterial bandwidth=(mean value-suture diameters of antibacterial band external diameter)/2.
Test result shows: network gutstring to intestinal bacteria and streptococcus aureus all without germ resistance, two kinds of bacteriums are all had good restraining effect by the made suture line of the present invention, after process 24h, it is 13.4mm to the antibacterial bandwidth of intestinal bacteria, it is 12.2mm to the antibacterial bandwidth of streptococcus aureus, but the increase with the treatment time, bacteriostatic action weakens gradually, after process 48h, the antibacterial bandwidth of intestinal bacteria and streptococcus aureus is respectively 7.83mm and 4.25mm, after process 72h, antibacterial bandwidth is contracted to 2.46mm and 1.67mm respectively, after process 96h, intestinal bacteria and streptococcus aureus are still had certain restraining effect by suture line, without bacterial reproduction under suture line, after process 120h, two kinds of bacteriums are all lost restraining effect, under suture line and surrounding have a large amount of bacterial reproduction. illustrate that the germ resistance of intestinal bacteria and streptococcus aureus all can be maintained 4 days by the made suture line of the present invention.
It should be appreciated that the embodiment more representational example that is the present invention, it is clear that the technical scheme of the present invention is not limited to above-described embodiment, it is also possible to have a lot of distortion.The those of ordinary skill of this area, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. there is the suture of bactericidal antiphlogistic effect, it is characterised in that, it is prepared from primarily of following bulk drugs, it is mass parts: Semen Firmianae 2-8, Herba Swertiae Puniceae 9-15, Silvery Aleuritopteris 6-15, Radix Glycyrrhizae Preparata 5-12, Herba Wahlenbergiae 2-6, water wax gourd root 3-9, Pericarpium Longan 2-6, Herba Elsholtziae Ciliatae 12-18, bamboo grove clouds 10-15, poly(lactic acid) 40-54, polyoxyethylene glycol 20-24, cm-chitosan 8-12.
2. there is the suture of bactericidal antiphlogistic effect as claimed in claim 1, it is characterised in that, Semen Firmianae 2-8, Herba Swertiae Puniceae 9-15, Silvery Aleuritopteris 6-15, Radix Glycyrrhizae Preparata 5-12, Herba Wahlenbergiae 2-6, water wax gourd root 3-9, Pericarpium Longan 2-6, Herba Elsholtziae Ciliatae 12-18, bamboo grove clouds 10-15, poly(lactic acid) 45-49, polyoxyethylene glycol 21-23, cm-chitosan 9-11.
3. there is the suture of bactericidal antiphlogistic effect as claimed in claim 1, it is characterised in that, Semen Firmianae 5, Herba Swertiae Puniceae 12, Silvery Aleuritopteris 10.5, Radix Glycyrrhizae Preparata 8.5, Herba Wahlenbergiae 4, water wax gourd root 6, Pericarpium Longan 4, Herba Elsholtziae Ciliatae 15, bamboo grove clouds 12.5, poly(lactic acid) 47, polyoxyethylene glycol 22, cm-chitosan 10.
4. the preparation method of the suture with bactericidal antiphlogistic effect as described in as arbitrary in claim 1-3, it is characterised in that, step is:
(1) water wax gourd root and Herba Elsholtziae Ciliatae being cleaned, mix thoroughly with ginger juice, leave standstill 30 minutes, take out, be placed in frying pan, slow fire heats, and fries to surface tawny, takes out, dry in the air cool;
(2) getting Semen Firmianae is placed in frying pan, and slow fire is heated to surperficial micro-drum, takes out, and adds refining mulse dipping 10-18 minute, take out, dry together with the bamboo grove clouds of section;
(3) being laid in steaming tray by Radix Glycyrrhizae, be placed in pot Steam by water bath, after big fire is boiled, Herba Swertiae Puniceae is put into steaming tray, fire of larding speech with literary allusions takes out, dries after steaming;
(4) Silvery Aleuritopteris, Radix Glycyrrhizae Preparata, Herba Wahlenbergiae, Pericarpium Longan are cleaned, pulverize and sieve together with step (1) (2) (3) made raw material, add dehydrated alcohol lixiviate, extracting at constant temperature 6-8 hour (preferred, lixiviate 7 hours) at 40-60 DEG C, lixiviate twice, take out filter, merging filtrate, vacuum distilling recycling design, obtained thick cream;
(5) dissolve poly(lactic acid) with methylene dichloride and it is configured to the poly(lactic acid) solution that mass concentration is 10%, add the made thick cream of step (4), mix thoroughly, add polyoxyethylene glycol again and cm-chitosan fully stirs, ultrasonic concussion 40-70 minute, filter, disappear bubble, obtains spinning solution;
(6) wet spinning technology is adopted to carry out spinning made for step (5) spinning solution, peptizer is water, first stretch bath is 50 DEG C of warm water, second stretch bath is 100 DEG C of boiling water, the long filament weaved is cut off, with 40 DEG C of water washings, takes out, dry 60-100 minute (preferred, dry 70-90 minute; More preferably, dry 80 minutes), obtained acid fiber by polylactic, adds and is twisted into suture line, sterilising packaging, obtain suture line.
5. there is the preparation method of the suture of bactericidal antiphlogistic effect as claimed in claim 4, it is characterised in that, step (2) dipping 12-16 minute (preferred, to flood 14 minutes).
6. there is the preparation method of the suture of bactericidal antiphlogistic effect as claimed in claim 4, it is characterised in that, step (3) is larded speech with literary allusions, and fire within pan-fried 20-35 minute, (preferred, decoct 24-31 minute by fire of larding speech with literary allusions;More preferably, fire of larding speech with literary allusions is decocted 27 minutes).
7. there is the preparation method of the suture of bactericidal antiphlogistic effect as claimed in claim 4, it is characterised in that, step (4) dehydrated alcohol consumption is 4-6 times (preferred, dehydrated alcohol consumption is 5 times of institute's lixiviate raw materials quality) of institute's lixiviate raw materials quality.
8. there is the preparation method of the suture of bactericidal antiphlogistic effect as claimed in claim 4, it is characterised in that, step (4) extraction temperature is 45-55 DEG C (preferred, extraction temperature is 50 DEG C).
9. there is the preparation method of the suture of bactericidal antiphlogistic effect as claimed in claim 4, it is characterised in that, step (5) ultrasonic concussion 50-60 minute (preferred, ultrasonic concussion 55 minutes).
10. there is the preparation method of the suture of bactericidal antiphlogistic effect as claimed in claim 4, it is characterised in that, step (6) drying temperature is 55-75 DEG C, and (preferred, drying temperature is 60-70 DEG C; More preferably, drying temperature is 65 DEG C).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510946853.9A CN105641736A (en) | 2015-12-17 | 2015-12-17 | Surgical suture with bactericidal and anti-inflammatory effects and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510946853.9A CN105641736A (en) | 2015-12-17 | 2015-12-17 | Surgical suture with bactericidal and anti-inflammatory effects and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112316198A (en) * | 2020-11-13 | 2021-02-05 | 浙江桐轩医疗科技有限公司 | Absorbable and degradable suture line |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0436308A1 (en) * | 1989-12-11 | 1991-07-10 | MITSUI TOATSU CHEMICALS, Inc. | Surgical filament |
| CN101584878A (en) * | 2008-05-23 | 2009-11-25 | 赵伶 | Operation suture containing Chinese and western bactericide or bacteriostat |
| CN104368039A (en) * | 2014-11-25 | 2015-02-25 | 苏州市贝克生物科技有限公司 | Medical absorbable suture line and preparation method thereof |
-
2015
- 2015-12-17 CN CN201510946853.9A patent/CN105641736A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0436308A1 (en) * | 1989-12-11 | 1991-07-10 | MITSUI TOATSU CHEMICALS, Inc. | Surgical filament |
| CN101584878A (en) * | 2008-05-23 | 2009-11-25 | 赵伶 | Operation suture containing Chinese and western bactericide or bacteriostat |
| CN104368039A (en) * | 2014-11-25 | 2015-02-25 | 苏州市贝克生物科技有限公司 | Medical absorbable suture line and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112316198A (en) * | 2020-11-13 | 2021-02-05 | 浙江桐轩医疗科技有限公司 | Absorbable and degradable suture line |
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Address after: Anshun City, Guizhou province Xixiu District 561000 Chinese Road No. 186 Building No. 4 2-702 Applicant after: Zhang Dexin Address before: 250000, room 2, unit 6, Changsheng District, 38 East Guan Street, Lixia District, Shandong,, Ji'nan Applicant before: Zhang Dexin |
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Application publication date: 20160608 |