CN105641734A - Preparation method of slow-release type bacterial cellulose based antibacterial agent - Google Patents
Preparation method of slow-release type bacterial cellulose based antibacterial agent Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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Abstract
The invention discloses a preparation method of a slow-release type bacterial cellulose based antibacterial agent. The preparation method comprises steps as follows: firstly, frozen and dried bacterial cellulose is subjected to in-situ reduction, nano-silver or copper particles are uniformly implanted in the bacterial cellulose, a nano-silver or copper supported bacterial cellulose composite is obtained and then put in an acidic or alkaline tetraethyl orthosilicate solution to be soaked, and the slow-release type bacterial cellulose based antibacterial agent covered with silicon dioxide on the surface is prepared after washing and drying. The preparation process is simple, the prepared slow-release type bacterial cellulose based antibacterial agent keeps high flexibility of bacterial cellulose and the nanostructure of metal particles, silicon dioxide on the surface of the antibacterial agent can prevent metal particles from dropping, silver or copper particles can be slowly diffused to the outer side of a spherical shell from the inner wall of the spherical shell through silicon dioxide mesopores, and the continuous antibacterial function is realized. The prepared bacterial cellulose based antibacterial agent has good stability and durable and stable antibacterial effects.
Description
Technical field
The invention belongs to the preparing technical field of antibacterial, the preparation method being specifically related to a kind of spacetabs type Bacterial cellulose based antimicrobials.
Background technology
Bacterial cellulose, also referred to as micro organism cellulose, produced by part antibacterial, in chemical composition similar with plant cellulose, but it is due to the nanoscale three-dimensional network structure of its uniqueness, excellent bioaffinity, biocompatibility, good mechanical property and excellent water holding capacity, extremely concerned in Wound dressing application aspect. Bacterial cellulose itself does not have the ability of antibacterial bacteriostatic, limits its use scope. At present, mainly through various methods to some functional particles of Bacterial cellulose load or group, prepare functional bacteria cellulose base Wound dressing, give Bacterial cellulose dressing antibacterial bacteriostatic function. Chinese patent CN101586309A utilizes the silver ion in the hydroxyl Adsorption For Ag ammonia solution on Bacterial cellulose, then generates nano silver/silver chloride using the chemical reagent containing aldehyde as reducing agent reaction. Chinese invention patent CN101905031A, adopts infusion method to prepare flamazine/bacterial cellulose composite membrane. But, in composite prepared by above method, metal particle forms coordination compound with the hydroxyl of Bacterial cellulose, and active force between the two is more weak, easy to fall off free, is directly exposed to the metal particle unstable chemcial property in air simultaneously, and anti-microbial property is not lasting.
Summary of the invention
For classical antibacterial agents in prior art because of silver or copper be carried on outer surface easily aoxidize, active component run off and anti-microbial property reduce problem, the preparation method that the invention provides the spacetabs type Bacterial cellulose based antimicrobials that a kind of chemical stability is good, durable antibacterial effect is stable.
Technical scheme is as follows:
A kind of preparation method of spacetabs type Bacterial cellulose based antimicrobials, with fermentation method prepare Bacterial cellulose for raw material, soaking normal direction Bacterial cellulose introduces silver ion or copper ion, Bacterial cellulose/silver or Bacterial cellulose/copper is prepared by in-situ reducing reaction, the silicon dioxide microsphere of hollow meso-hole structure is covered Bacterial cellulose/silver or the surface of Bacterial cellulose/copper by the hydrolysis condensation reaction again through tetraethyl orthosilicate, specifically comprises the following steps that
Step 1, by Bacterial cellulose lyophilization;
Step 2, is immersed in silver salt or copper salt solution by dried Bacterial cellulose, adds reducing agent, stirring reaction after taking-up, and reaction terminates post rinse and removes moisture;
Step 3, Bacterial cellulose step 2 obtained soaks 12��48 hours in the acidity or alkaline solution of tetraethyl orthosilicate, isolated by filtration afterwards, and washing is drying to obtain spacetabs type Bacterial cellulose based antimicrobials.
In step 1, described Bacterial cellulose is Acetobacter pasteurianus, product acetobacter, glucose bacillus, acetobacter xylinum, Agrobacterium, root nodule bacteria, Pseudomonas cepacia, sarcina, acetifies the Bacterial cellulose that bacillus, Pseudomonas cocovenenans or campylobacter jejuni produce, and the cryodesiccated time is 12��48 hours.
In step 2, described silver salt is silver nitrate or 2 ethyl hexanoic acid silver, described mantoquita is copper chloride, copper sulfate or copper nitrate, the mass ratio of described silver salt or mantoquita and Bacterial cellulose is 0.01��0.1:1, the stirring reaction time is 2��48 hours, described reducing agent selected from ascorbic acid, boron potassium cyanide, boron Cyanogran., formaldehyde one or more, the mass ratio of reducing agent and silver salt or mantoquita is 0.1��10:1, and stirring reaction temperature is 0��50 DEG C.
In step 3, the concentration of described teos solution is 0.5��30wt%, and in acid solution, acid is one or more in hydrochloric acid, sulphuric acid, phosphoric acid, acetic acid, and concentration is 0.001��10M; In alkaline solution alkali be ammonia, sodium hydroxide, potassium hydroxide, sodium carbonate one or more, concentration is 0.001��10M; Soaking temperature is 0��60 DEG C, and washing times is 1��5 time, dries as vacuum drying or lyophilization.
Compared with prior art, the remarkable advantage of the present invention is as follows:
The present invention utilizes the hydrolysis condensation reaction of tetraethyl orthosilicate that silicon dioxide is covered in the surface of Bacterial cellulose/silver or Bacterial cellulose/copper, a large amount of oxygen atoms of silica surface can form valence link with silver or copper atom, can there is polycondensation reaction with the hydroxyl of Bacterial cellulose or form hydrogen bond in silanol simultaneously, make silicon dioxide can be anchored on the surface of Bacterial cellulose/silver or Bacterial cellulose/copper firmly, effectively prevent the come off active component that causes of functional particles to run off, improve the chemical stability of material; Hollow that simultaneously silicon dioxide microsphere has and meso-hole structure, can be slowly diffused into outside spherical shell from mesoporous spherical shell at the silver of silicon dioxide spherical shell inwall or copper, play the effect that Continuous sterilization is antibacterial, bacteria cellulose-base dressing chemical stability prepared by the present invention is good, durable antibacterial effect is stable, can preserve for a long time.
Accompanying drawing explanation
The spacetabs type Bacterial cellulose based antimicrobials that Fig. 1 is silicon dioxide covering Bacterial cellulose/silver is the bacteriostatic experiment result figure to staphylococcus aureus.
Fig. 2 is that silicon dioxide covers the spacetabs type Bacterial cellulose based antimicrobials of the Bacterial cellulose/copper bacteriostatic experiment result figure to staphylococcus aureus.
Detailed description of the invention
Below in conjunction with embodiment and accompanying drawing, the present invention is described in further detail.
Embodiment 1
Step 1, is placed in freezer dryer lyophilization 12 hours by Bacterial cellulose;
Step 2, the Bacterial cellulose dried by 1g is immersed in the solution containing 0.01g silver nitrate, then takes out solids, adds 0.01g boron potassium cyanide and reacts 2 hours at 0 DEG C, then rinses products therefrom and remove moisture;
Step 3, the Bacterial cellulose that upper step processes is joined (concentration of hydrochloric acid is 0.001M) in the hydrochloric acid solution of 0.5wt% tetraethyl orthosilicate, 0 DEG C is soaked 12 hours, prepare the composite of Bacterial cellulose and silicon dioxide, by product isolated by filtration, it is drying to obtain spacetabs type Bacterial cellulose based antimicrobials with 3 final vacuums of deionized water wash.
Fig. 1 is that silicon dioxide prepared by the present embodiment covers the spacetabs type Bacterial cellulose based antimicrobials of the Bacterial cellulose/silver bacteriostatic experiment result to staphylococcus aureus, the inhibition zone of radius 4mm is had around this Bacterial cellulose based antimicrobials, and the Bacterial cellulose of blank does not have inhibition zone, illustrate that the spacetabs type Bacterial cellulose based antimicrobials of prepared silicon dioxide covering Bacterial cellulose/silver has good antibacterial effect.
Embodiment 2
Step 1, is placed in freezer dryer lyophilization 16 hours by Bacterial cellulose;
Step 2, the Bacterial cellulose dried by 1g is immersed in containing, in 0.1g copper nitrate solution, then taking out solids, adds 0.2g boron Cyanogran. and reacts 48 hours at 50 DEG C, then rinses products therefrom and remove moisture;
Step 3, the Bacterial cellulose that upper step processes is joined (acetate concentration is 10M) in the acetum of 30wt% tetraethyl orthosilicate, 60 DEG C are soaked 15 hours, prepare the composite of Bacterial cellulose and silicon dioxide, by product isolated by filtration, namely obtain spacetabs type Bacterial cellulose based antimicrobials with 1 postlyophilization of deionized water wash.
Fig. 2 is that silicon dioxide prepared by the present embodiment covers the spacetabs type Bacterial cellulose based antimicrobials of the Bacterial cellulose/copper bacteriostatic experiment result to staphylococcus aureus, the inhibition zone of radius 3mm is had around this Bacterial cellulose based antimicrobials, and the Bacterial cellulose of blank does not have inhibition zone, illustrate that the spacetabs type Bacterial cellulose based antimicrobials of prepared silicon dioxide covering Bacterial cellulose/copper has good antibacterial effect.
Embodiment 3
Step 1, is placed in freezer dryer lyophilization 18 hours by Bacterial cellulose;
Step 2, is immersed in dried for 1g Bacterial cellulose containing, in 0.05g copper nitrate solution, then taking out solids, adds 0.2g formaldehyde and reacts 36 hours at 10 DEG C, then rinses products therefrom and remove moisture;
Step 3, the Bacterial cellulose that upper step processes is joined (naoh concentration is 0.001M) in the sodium hydroxide solution of 15wt% tetraethyl orthosilicate, 30 DEG C are soaked 48 hours, prepare the composite of Bacterial cellulose and silicon dioxide, by product isolated by filtration, namely obtain spacetabs type Bacterial cellulose based antimicrobials with 2 postlyophilizations of deionized water wash.
Embodiment 4
Step 1, is placed in freezer dryer lyophilization 48 hours by Bacterial cellulose;
Step 2, the Bacterial cellulose dried by 1g is immersed in containing, in 0.02g copper-bath, then taking out solids, adds 0.2g ascorbic acid and reacts 20 hours at 40 DEG C, then rinses products therefrom and remove moisture;
Step 3, the Bacterial cellulose that upper step processes is joined (ammonia concn is 0.005M) in the ammonia spirit of 10wt% tetraethyl orthosilicate, 30 DEG C are soaked 48 hours, prepare the composite of Bacterial cellulose and silicon dioxide, by product isolated by filtration, it is drying to obtain spacetabs type Bacterial cellulose based antimicrobials with 2 final vacuums of deionized water wash.
Embodiment 5
Step 1, is placed in freezer dryer lyophilization 36 hours by Bacterial cellulose;
Step 2, the Bacterial cellulose dried by 1g is immersed in containing, in 0.06g2-thylhexoic acid silver solution, then taking out solids, adds 0.06g formaldehyde and reacts 15 hours at 30 DEG C, then rinses products therefrom and remove moisture;
Step 3, the Bacterial cellulose that upper step processes is joined (concentration of potassium hydroxide is 1M) in the potassium hydroxide solution of 12wt% tetraethyl orthosilicate, 20 DEG C are soaked 20 hours, prepare the composite of Bacterial cellulose and silicon dioxide, by product isolated by filtration, it is drying to obtain spacetabs type Bacterial cellulose based antimicrobials with 3 final vacuums of deionized water wash.
Embodiment 6
Step 1, is placed in freezer dryer lyophilization 24 hours by Bacterial cellulose;
Step 2, the Bacterial cellulose dried by 1g is immersed in 0.01g2-thylhexoic acid silver solution, then takes out solids, adds 0.05g sodium borohydride and reacts 2 hours at 20 DEG C, then rinses products therefrom and remove moisture;
Step 3, the Bacterial cellulose that upper step processes is joined (phosphoric acid concentration is 5M) in the phosphoric acid solution of 28wt% tetraethyl orthosilicate, 35 DEG C are soaked 12 hours, prepare the composite of Bacterial cellulose and silicon dioxide, by product isolated by filtration, namely obtain spacetabs type Bacterial cellulose based antimicrobials with 5 postlyophilizations of deionized water wash.
Embodiment 7
Step 1, is placed in freezer dryer lyophilization 15 hours by Bacterial cellulose;
Step 2, the Bacterial cellulose dried by 1g is immersed in containing, in 0.05g copper nitrate solution, then taking out solids, adds 0.02g potassium borohydride and reacts 6 hours at 20 DEG C, then rinses products therefrom and remove moisture;
Step 3, the Bacterial cellulose that upper step processes is joined (acetate concentration is 0.01M) in the sodium carbonate liquor of 20% tetraethyl orthosilicate, 50 DEG C are soaked 36 hours, prepare the composite of Bacterial cellulose and silicon dioxide, by product isolated by filtration, it is drying to obtain spacetabs type Bacterial cellulose based antimicrobials with 5 final vacuums of deionized water wash.
Embodiment 8
Step 1, is placed in freezer dryer lyophilization 16 hours by Bacterial cellulose;
Step 2, the Bacterial cellulose dried by 1g is immersed in containing, in 0.08g copper chloride solution, then taking out solids, adds 0.08g sodium borohydride and 0.08g potassium borohydride and reacts 2 hours at 30 DEG C, then rinses products therefrom and remove moisture;
Step 3, the Bacterial cellulose that upper step processes is joined (sulfuric acid concentration is 0.002M) in the sulfuric acid solution of 10wt% tetraethyl orthosilicate, 20 DEG C are soaked 48 hours, prepare the composite of Bacterial cellulose and silicon dioxide, by product isolated by filtration, namely obtain spacetabs type Bacterial cellulose based antimicrobials with 4 postlyophilizations of deionized water wash.
Embodiment 9
Step 1, is placed in freezer dryer lyophilization 14 hours by Bacterial cellulose;
Step 2, the Bacterial cellulose dried by 1g is immersed in containing, in 0.04g silver nitrate solution, then taking out solids, adds 0.08g sodium borohydride and 0.08g potassium borohydride and reacts 2 hours at 30 DEG C, then rinses products therefrom and remove moisture;
Step 3, the Bacterial cellulose that upper step processes is joined in the acetate and hydrochloride mixed solution of 10wt% tetraethyl orthosilicate (acetate concentration is 0.01M, concentration of hydrochloric acid is 0.002M), 20 DEG C are soaked 48 hours, prepare the composite of Bacterial cellulose and silicon dioxide, by product isolated by filtration, namely obtain spacetabs type Bacterial cellulose based antimicrobials with 4 postlyophilizations of deionized water wash.
Embodiment 10
Step 1, is placed in freezer dryer lyophilization 15 hours by Bacterial cellulose;
Step 2, the Bacterial cellulose dried by 1g is immersed in containing, in 0.1g silver nitrate solution, then taking out solids, adds 0.01g sodium borohydride and reacts 2 hours at 30 DEG C, then rinses products therefrom and remove moisture;
Step 3, the Bacterial cellulose that upper step processes is joined in the potassium hydroxide of 10wt% tetraethyl orthosilicate and sodium hydroxide mixed solution (concentration of potassium hydroxide is 0.01M, naoh concentration is 0.002M), 30 DEG C are soaked 36 hours, prepare the composite of Bacterial cellulose and silicon dioxide, by product isolated by filtration, namely obtain spacetabs type Bacterial cellulose based antimicrobials with 4 postlyophilizations of deionized water wash.
Claims (4)
1. the preparation method of a spacetabs type Bacterial cellulose based antimicrobials, it is characterised in that specifically comprise the following steps that
Step 1, by Bacterial cellulose lyophilization;
Step 2, is immersed in silver salt or copper salt solution by dried Bacterial cellulose, adds reducing agent, stirring reaction after taking-up, and reaction terminates post rinse and removes moisture;
Step 3, Bacterial cellulose step 2 obtained soaks 12��48 hours in the acidity or alkaline solution of tetraethyl orthosilicate, isolated by filtration afterwards, and washing is drying to obtain spacetabs type Bacterial cellulose based antimicrobials.
2. the preparation method of a kind of spacetabs type Bacterial cellulose based antimicrobials according to claim 1, it is characterized in that, in step 1, described Bacterial cellulose is Acetobacter pasteurianus, product acetobacter, glucose bacillus, acetobacter xylinum, Agrobacterium, root nodule bacteria, Pseudomonas cepacia, sarcina, acetifies the Bacterial cellulose that bacillus, Pseudomonas cocovenenans or campylobacter jejuni produce, and the cryodesiccated time is 12��48 hours.
3. the preparation method of a kind of spacetabs type Bacterial cellulose based antimicrobials according to claim 1, it is characterized in that, in step 2, described silver salt is silver nitrate or 2 ethyl hexanoic acid silver, described mantoquita is copper chloride, copper sulfate or copper nitrate, the mass ratio of described silver salt or mantoquita and Bacterial cellulose is 0.01��0.1:1, the stirring reaction time is 2��48 hours, described reducing agent is selected from ascorbic acid, boron potassium cyanide, boron Cyanogran., one or more of formaldehyde, the mass ratio of reducing agent and silver salt or mantoquita is 0.1��10:1, stirring reaction temperature is 0��50 DEG C.
4. the preparation method of a kind of spacetabs type Bacterial cellulose based antimicrobials according to claim 1, it is characterized in that, in step 3, the concentration of described teos solution is 0.5��30wt%, in acid solution, acid is one or more in hydrochloric acid, sulphuric acid, phosphoric acid, acetic acid, and concentration is 0.001��10M; In alkaline solution alkali be ammonia, sodium hydroxide, potassium hydroxide, sodium carbonate one or more, concentration is 0.001��10M; Soaking temperature is 0��60 DEG C, and washing times is 1��5 time, dries as vacuum drying or lyophilization.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107006518A (en) * | 2017-04-26 | 2017-08-04 | 连云港师范高等专科学校 | A kind of preparation method of the plain composite of antibiotic carbon fiber |
| CN108018744A (en) * | 2017-11-08 | 2018-05-11 | 天津科技大学 | A kind of preparation method of multifunctional modification filter paper |
| CN108997620A (en) * | 2018-08-03 | 2018-12-14 | 武汉工程大学 | A kind of mesoporous silicon oxide of carbonate protection and cellulose blending film and its preparation method and application |
| CN109260053A (en) * | 2018-11-20 | 2019-01-25 | 天津科技大学 | The preparation method of the disposable Bacteriostasis Emulsion of permeable water base in a kind of zero skin |
| CN111228302A (en) * | 2020-02-27 | 2020-06-05 | 青岛科技大学 | Antibacterial hydrogel and preparation method and application thereof |
| CN112500674A (en) * | 2020-10-28 | 2021-03-16 | 合肥创农生物科技有限公司 | Antibacterial, algae-proof and anti-discoloration water culture tank material and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107006518A (en) * | 2017-04-26 | 2017-08-04 | 连云港师范高等专科学校 | A kind of preparation method of the plain composite of antibiotic carbon fiber |
| CN108018744A (en) * | 2017-11-08 | 2018-05-11 | 天津科技大学 | A kind of preparation method of multifunctional modification filter paper |
| CN108997620A (en) * | 2018-08-03 | 2018-12-14 | 武汉工程大学 | A kind of mesoporous silicon oxide of carbonate protection and cellulose blending film and its preparation method and application |
| CN109260053A (en) * | 2018-11-20 | 2019-01-25 | 天津科技大学 | The preparation method of the disposable Bacteriostasis Emulsion of permeable water base in a kind of zero skin |
| CN109260053B (en) * | 2018-11-20 | 2021-06-18 | 天津科技大学 | Preparation method of water-based wash-free antibacterial emulsion with zero skin internal permeability |
| CN111228302A (en) * | 2020-02-27 | 2020-06-05 | 青岛科技大学 | Antibacterial hydrogel and preparation method and application thereof |
| CN112500674A (en) * | 2020-10-28 | 2021-03-16 | 合肥创农生物科技有限公司 | Antibacterial, algae-proof and anti-discoloration water culture tank material and preparation method thereof |
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Application publication date: 20160608 |