CN102293689B - Nano-silver testicular prosthesis - Google Patents
Nano-silver testicular prosthesis Download PDFInfo
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- CN102293689B CN102293689B CN2011102117228A CN201110211722A CN102293689B CN 102293689 B CN102293689 B CN 102293689B CN 2011102117228 A CN2011102117228 A CN 2011102117228A CN 201110211722 A CN201110211722 A CN 201110211722A CN 102293689 B CN102293689 B CN 102293689B
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Abstract
The invention relates to a nano-silver testicular prosthesis. The testicular prosthesis is a silica gel testicular prosthesis, nano-grade Ag-SiO2 particles are coated on the outer surface of the testicular prosthesis, and the mass ratio of SiO2 to silver in the Ag-SiO2 particles is (5:1)-(2:1). The invention also provides a preparation method and application of the testicular prosthesis. The invention has the advantages that: the infection incidence is greatly reduced due to high Ag<+> content and strong antimicrobial capability, so that the nano-silver testicular prosthesis can constantly resist bacteria without drug resistance and avoid repeated infection, tissue healing is accelerated and function recovery is promoted; the preparation process is simple and is easy to control, the cost is saved, Ag<+> is uniformly distributed and firmly immobilized, the nano-grade SiO2 and nano-silver have higher yield, and the nano-silver in the prepared nano-silver testicular prosthesis is uniformly distributed and hard to drop; and the nano-silver testicular prosthesis meets the requirement of patients on mental health, plays a good role in resisting bacteria, and has a great potential in clinical application.
Description
Technical field
The present invention relates to a kind of medical science implanting prosthetic, specifically, is a kind of antibacterial nano-silver testicular prosthesis and its preparation method and application.
Background technology
Often can see the absence of testis that a variety of causes causes clinically, testis is not only an organ while with reproduction and endocrine function, and it is also male's important symbol, therefore, absence of testis and male castration are concerning the patient, be not only the forfeiture of biorgan, also can produce psychological defect.The testicular prosthesis orthopedic treatment has played positive effect concerning this class patient, be beneficial to its physical and mental health.Implantation of testicular prosthesis is applied decades clinically, but the same with other implant surgery, and postoperative likely have complication such as infection.The clinician can pass through the generation that changes modus operandi, strengthens the method minimizing infection such as peri-operative nursing care, in general, prevents that the important measures of postoperative infection generation from using antibiotic exactly.
In recent years, silver ion more and more causes people's attention as antibacterial, and flourish nanotechnology in recent years can be prepared into silver nanoparticle the novel nano ag material.Nanometer silver is Powdered nanometer-level silver simple substance, and particle diameter is generally between 25-50nm, and nanometer silver has higher specific surface area, and more high activity surface atom.The nanometer silver surface can discharge silver and other different types of money base groups, the silver the when ability of these money bases group kill bacteria is better than independent role, and money base group strengthens the antibacterial action of silver greatly.Nanometer silver is used widely clinically as antibacterial.
Nanometer silver plays sterilizing effect by the processes such as structure that hinder pathogenic organisms chemosynthesis, destruction enzyme.Nanometer silver has following characteristics as antibacterial: 1. broad-spectrum antiseptic, can suppress and kill drug resistance escherichia coli, drug resistance golden staphylococci, drug-resistant pseudomonas aeruginosa, streptococcus pyogenes, drug resistance enterococcus, the multiple drug-resistant bacterias such as anaerobe; 2. potent sterilization, can be at the rapid kill pathogenic organisms of low concentration; 3. can slowly discharge in vivo durable antibiotic; 4. permeability is strong, can infiltrate rapidly and organize the depths sterilization; Thereby can promote the reparation of damaged cell and regeneration to promote wound healing; 5. physical antibacterial, have no drug resistance, and protects from infection and repeatedly occur; 6. have better histocompatibility, be not easy to cause and organize foreign body reaction; 7. safety non-toxic.
Chinese patent literature CN:1947802A discloses a kind of slow-releasing testicular prosthesis and application thereof, this slow-releasing testicular prosthesis, formed by silicone rubber, androgen, silicone rubber, androgen weight ratio are 2:1-4-1, this invention is by combining silastic material with testosterone, the testicular prosthesis that preparation has the androgen slow-release capability, thus the replacement therapy of testicular prosthesis and androgen treatment are effectively united.Chinese patent literature CN:2863155Y discloses a kind of antibiotic medical urinary catheter, comprises the catheter body, at the outer surface of described catheter body, is coated with the nanometer silver coating.Chinese patent literature CN:1597009A discloses a kind of nanometer antibacterial urinary catheter, formed by common basic unit and surface coating, it is characterized in that surface coating made by the glue that mixes nano metal ion sterilizing anti-biotic material, common basic unit is made by conventional glue, and nano metal ion sterilizing anti-biotic material is nanometer silver or nano-titanium.But implant nano-silver testicular prosthesis about the medical science antibiotic property and yet there are no report.
Summary of the invention
The objective of the invention is provides a kind of nano-silver testicular prosthesis for deficiency of the prior art.
One purpose more of the present invention is that a kind of preparation method of nano-silver testicular prosthesis is provided
Another purpose of the present invention is that a kind of application of nano-silver testicular prosthesis is provided.
For achieving the above object, the technical scheme that the present invention takes is: a kind of nano-silver testicular prosthesis, described testicular prosthesis are the silica gel testicular prosthesis, described testicular prosthesis outer surface coating nanoscale Ag-SiO
2Granule, described Ag-SiO
2SiO in granule
2With the mass ratio of silver be 5:1-2:1.
Described Ag-SiO
2SiO in granule
2With the mass ratio of silver be 3:1-2:1.
Described nano-silver testicular prosthesis is made by following steps:
A, 0.5-50g nanometer SiO
2Powder joins in the silver nitrate solution that concentration is 0.006-0.8mol/L, stirs, and adjusts pH value in the scope of 6-8, carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 4-5 hour;
Reaction in b, step a is carried out centrifugalize to reactant liquor after finishing, isolated solid sample is dissolved in deionized water and washs, until in solution without silver ion;
C, with the sample that obtains in step b at the vacuum desiccator inner drying, namely make nanometer Ag-SiO
2Antibacterial;
D, common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soak in solution, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
Described nano-silver testicular prosthesis is made by following steps:
A, 5g nanometer SiO
2Powder joins in the silver nitrate solution that concentration is 0.07mol/L, stirs, and adjusts pH value in the scope of 6-8, carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 4-5 hour;
Reaction in b, step a is carried out centrifugalize to reactant liquor after finishing, isolated solid sample is dissolved in deionized water and washs, until in solution without silver ion;
C, with the sample that obtains in step b vacuum desiccator inner drying 24 hours, namely make nanometer Ag-SiO
2Antibacterial;
D, common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soaked in solution 15 minutes, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
For realizing above-mentioned second purpose, the technical scheme that the present invention takes is: a kind of preparation method of nano-silver testicular prosthesis, and described preparation method comprises the following steps:
A, 0.5-50g nanometer SiO
2Powder joins in the silver nitrate solution that concentration is 0.006-0.8mol/L, stirs, and adjusts pH value in the scope of 6-8, carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 4-5 hour;
Reaction in b, step a is carried out centrifugalize to reactant liquor after finishing, isolated solid sample is dissolved in deionized water and washs, until in solution without silver ion;
C, with the sample that obtains in step b at the vacuum desiccator inner drying, namely make nanometer Ag-SiO
2Antibacterial;
D, common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soak in solution, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
Described preparation method comprises the following steps:
A, 5g nanometer SiO
2Powder joins in the silver nitrate solution that concentration is 0.07mol/L, stirs, and adjusts pH value in the scope of 6-8, carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 4-5 hour;
Reaction in b, step a is carried out centrifugalize to reactant liquor after finishing, isolated solid sample is dissolved in deionized water and washs, until in solution without silver ion;
C, with the sample that obtains in step b vacuum desiccator inner drying 24 hours, namely make nanometer Ag-SiO
2Antibacterial;
D, common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soaked in solution 15 minutes, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
For realizing above-mentioned the 3rd purpose, the technical scheme that the present invention takes is: the application of described nano-silver testicular prosthesis in preparation treatment absence of testis disease medicament.
The invention has the advantages that:
1, the Ag of nano-silver testicular prosthesis of the present invention
+Content is high, and antibacterial ability is strong, has greatly reduced infection rate, can durable antibiotic, avoid postoperative chronic infection, and have no drug resistance, avoid occurring repeated infection, accelerate organization healing, promotion functions recovers;
What 2, preparation technology adopted is easy operating process, and reaction condition comparatively simply and is easily controlled, and does not need additionally to add other reagent, saves cost, Ag
+Be evenly distributed on antibacterial material, fixation, simultaneously reach again slow release can continue antibacterial effect, nanoscale SiO
2Higher with nanometer silver output, in the nano-silver testicular prosthesis of preparing, nanometer silver is evenly distributed, difficult drop-off;
3, nano-silver testicular prosthesis of the present invention can meet patient's needs aspect mental health, can play good antibacterial effect again, and very large potentiality are arranged in clinical practice.
Description of drawings
Accompanying drawing 1 is the outward appearance pictorial diagram of nano-silver testicular prosthesis of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing, the specific embodiment provided by the invention is elaborated.
The preparation of embodiment 1 nano-silver testicular prosthesis
Take 0.5g nanometer SiO
2It is in the silver nitrate solution of 0.006mol/L that powder joins the 100ml concentration for preparing, and fully stirs, and adjusts and keep the pH value of solution in the scope of 6-8, then carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 4 hours.After reaction finishes, reactant liquor is carried out centrifugalize, isolated solid sample is dissolved in deionized water and washs, so repeatedly several times, until in solution without silver ion.Finally with treated sample vacuum desiccator inner drying 24 hours, namely make nanometer Ag-SiO
2Antibacterial.
Common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soaked in solution 15 minutes, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
The preparation of embodiment 2 nano-silver testicular prosthesis
Take 50g nanometer SiO
2It is in the silver nitrate solution of 0.8mol/L that powder joins the 100ml concentration for preparing, and fully stirs, and adjusts and keep the pH value of solution in the scope of 6-8, then carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 5 hours.After reaction finishes, reactant liquor is carried out centrifugalize, isolated solid sample is dissolved in deionized water and washs, so repeatedly several times, until in solution without silver ion.Finally with treated sample vacuum desiccator inner drying 24 hours, namely make nanometer Ag-SiO
2Antibacterial.
Common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soaked in solution 15 minutes, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
The preparation of embodiment 3 nano-silver testicular prosthesis
Take 5g nanometer SiO
2It is in the silver nitrate solution of 0.07mol/L that powder joins the 100ml concentration for preparing, and fully stirs, and adjusts and keep the pH value of solution in the scope of 6-8, then carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 4 hours.After reaction finishes, reactant liquor is carried out centrifugalize, isolated solid sample is dissolved in deionized water and washs, so repeatedly several times, until in solution without silver ion.Finally with treated sample vacuum desiccator inner drying 24 hours, namely make nanometer Ag-SiO
2Antibacterial.
Common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soaked in solution 15 minutes, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
The preparation of embodiment 4 nano-silver testicular prosthesis
Take 2g nanometer SiO
2It is in the silver nitrate solution of 0.02mol/L that powder joins the 100ml concentration for preparing, and fully stirs, and adjusts and keep the pH value of solution in the scope of 6-8, then carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 4 hours.After reaction finishes, reactant liquor is carried out centrifugalize, isolated solid sample is dissolved in deionized water and washs, so repeatedly several times, until in solution without silver ion.Finally with treated sample vacuum desiccator inner drying 24 hours, namely make nanometer Ag-SiO
2Antibacterial.
Common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soaked in solution 15 minutes, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
The preparation of embodiment 5 nano-silver testicular prosthesis
Take 25g nanometer SiO
2It is in the silver nitrate solution of 0.4mol/L that powder joins the 100ml concentration for preparing, and fully stirs, and adjusts and keep the pH value of solution in the scope of 6-8, then carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 5 hours.After reaction finishes, reactant liquor is carried out centrifugalize, isolated solid sample is dissolved in deionized water and washs, so repeatedly several times, until in solution without silver ion.Finally with treated sample vacuum desiccator inner drying 24 hours, namely make nanometer Ag-SiO
2Antibacterial.
Common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soaked in solution 15 minutes, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
The preparation of embodiment 6 nano-silver testicular prosthesis
Take 10g nanometer SiO
2It is in the silver nitrate solution of 0.14mol/L that powder joins the 100ml concentration for preparing, and fully stirs, and adjusts and keep the pH value of solution in the scope of 6-8, then carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 4 hours.After reaction finishes, reactant liquor is carried out centrifugalize, isolated solid sample is dissolved in deionized water and washs, so repeatedly several times, until in solution without silver ion.Finally with treated sample vacuum desiccator inner drying 24 hours, namely make nanometer Ag-SiO
2Antibacterial.
Common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soaked in solution 15 minutes, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
The preparation of embodiment 7 nano-silver testicular prosthesis
Take 2.5g nanometer SiO
2It is in the silver nitrate solution of 0.035mol/L that powder joins the 100ml concentration for preparing, and fully stirs, and adjusts and keep the pH value of solution in the scope of 6-8, then carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 5 hours.After reaction finishes, reactant liquor is carried out centrifugalize, isolated solid sample is dissolved in deionized water and washs, so repeatedly several times, until in solution without silver ion.Finally with treated sample vacuum desiccator inner drying 24 hours, namely make nanometer Ag-SiO
2Antibacterial.
Common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soaked in solution 15 minutes, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
The preparation of embodiment 8 nano-silver testicular prosthesis
Take 45g nanometer SiO
2It is in the silver nitrate solution of 0.6mol/L that powder joins the 100ml concentration for preparing, and fully stirs, and adjusts and keep the pH value of solution in the scope of 6-8, then carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 5 hours.After reaction finishes, reactant liquor is carried out centrifugalize, isolated solid sample is dissolved in deionized water and washs, so repeatedly several times, until in solution without silver ion.Finally with treated sample vacuum desiccator inner drying 24 hours, namely make nanometer Ag-SiO
2Antibacterial.
Common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soaked in solution 15 minutes, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
Please refer to accompanying drawing 1, accompanying drawing 1 is the outward appearance pictorial diagram of nano-silver testicular prosthesis of the present invention.
Embodiment 9
Chinese patent literature CN:2863155Y discloses a kind of antibiotic medical urinary catheter, comprises the catheter body, at the outer surface of described catheter body, is coated with the nanometer silver coating.This utility model is directly at catheter outer surface coated with nano silver coating, and the nano silver material that this mode applies is less, and easily comes off, and can not reach good antibacterial bacteriostatic effect.Chinese patent literature CN:1597009A discloses a kind of nanometer antibacterial urinary catheter, formed by common basic unit and surface coating, it is characterized in that surface coating made by the glue that mixes nano metal ion sterilizing anti-biotic material, common basic unit is made by conventional glue, and nano metal ion sterilizing anti-biotic material is nanometer silver or nano-titanium.Although this invention has applied the conventional glue that mixes nanometer silver at the catheter skin, but the mass ratio of nanometer silver and conventional glue is not disclosed, and while preparing this coating except metal ion and conventional glue, also need add the materials such as ammonia and diffusant, increased production cost, also make production technology more complicated, be not easy to promote.The present invention adopts coated with nano Ag-SiO on testicular prosthesis
2Mode, in the nano-silver testicular prosthesis of preparing, nanometer silver is evenly distributed, difficult drop-off, because nanoscale SiO
2Particle diameter is little, specific surface area is large, there are a large amount of unsaturated bonds on surface, has very high surface activity, is suitable as Ag most
+Carrier.
Chinese patent literature CN:1597009A discloses a kind of nanometer silver take inorganic, metal oxide as carrier and preparation method thereof, and the surface of being adhered to the inorganic, metal oxide powder by nano-Ag particles forms, and inorganic, metal oxide comprises SiO
2, TiO
2, ZrO
2Deng, the content of the complex nanometer silver that makes is 0.5-8% weight.The SiO of disclosed carrying nano silver in prior art
2Middle SiO
2With the mass ratio of silver usually all lower than 10:1, and Ag-SiO of the present invention
2SiO in granule
2With the mass ratio of silver be 5:1-2:1, can find out Ag-SiO of the present invention from mass ratio
2Can the more Ag of load on granule
+, and the antibacterial and bacteriostasis of nano-silver testicular prosthesis is mainly to rely on Ag
+, so nanoscale Ag-SiO of the present invention
2Particle Phase has better antibiotic and fungistatic effect certainly than foregoing invention and prior art., because reach this ratio, can utilize to greatest extent SiO
2The unsaturated bond on surface, make SiO
2Can the more Ag of load on granule
+Thereby, make the bactericidal effect of nano-silver testicular prosthesis better, lasting fungistatic effect is stronger.In the nano-silver testicular prosthesis of preparing, nanometer silver is evenly distributed, and difficult drop-off can make Ag
+Be evenly distributed on antibacterial material, fixation, simultaneously reach again slow release can continue antibacterial effect.
Prepare nanoscale Ag-SiO in prior art
2The method of grain coating, except silver nitrate solution and SiO
2All need in addition to add ammonia, surfactant, reducing agent or bases, preparation method of the present invention only needs silver nitrate solution and SiO
2React under certain reaction condition, do not need to add other materials, greatly saved production cost, while also having avoided adding the solution such as ammonia to pollution and the murder by poisoning of environment and Producer.Preparation technology of the present invention is very simple simultaneously, and carrier silica gel and silver-colored reaction condition comparatively simply and are easily controlled, and does not need the technique of expensive equipment and complexity, more extensively promotes.
Nano-silver testicular prosthesis of the present invention, its advantage shows: what adopt in preparation technology is easy operating process, carrier silica gel and silver-colored reaction condition are comparatively simple and easily control nanoscale SiO
2Higher with nanometer silver output, in the nano-silver testicular prosthesis of preparing, nanometer silver is evenly distributed, difficult drop-off.Can meet the patient at needs aspect mental health with the nano-silver testicular prosthesis of the present invention's preparation, can play good antibacterial effect again, very large potentiality are arranged in clinical practice afterwards.
The above is only the preferred embodiment of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; can also make some improvement and supplement, these improvement and supplement and also should be considered as protection scope of the present invention.
Claims (2)
1. a nano-silver testicular prosthesis, is characterized in that, described testicular prosthesis is the silica gel testicular prosthesis, described testicular prosthesis outer surface coating nanoscale Ag-SiO
2Granule, described Ag-SiO
2SiO in granule
2With the mass ratio of silver be 3:1-2:1, described nano-silver testicular prosthesis is made by following steps:
A, 5g nanometer SiO
2Powder joins in the silver nitrate solution that concentration is 0.07mol/L, stirs, and adjusts pH value in the scope of 6-8, carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 4-5 hour;
Reaction in b, step a is carried out centrifugalize to reactant liquor after finishing, isolated solid sample is dissolved in deionized water and washs, until in solution without silver ion;
C, with the sample that obtains in step b vacuum desiccator inner drying 24 hours, namely make nanometer Ag-SiO
2Antibacterial;
D, common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soaked in solution 15 minutes, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
2. the preparation method of a nano-silver testicular prosthesis, is characterized in that, described preparation method comprises the following steps:
A, 5g nanometer SiO
2Powder joins in the silver nitrate solution that concentration is 0.07mol/L, stirs, and adjusts pH value in the scope of 6-8, carries out adsorption reaction under 50 ℃ of lucifuge conditions, and the time is 4-5 hour;
Reaction in b, step a is carried out centrifugalize to reactant liquor after finishing, isolated solid sample is dissolved in deionized water and washs, until in solution without silver ion;
C, with the sample that obtains in step b vacuum desiccator inner drying 24 hours, namely make nanometer Ag-SiO
2Antibacterial;
D, common silica gel testicular prosthesis is placed in nanometer Ag-SiO
2Soaked in solution 15 minutes, after natural drying, then in firming agent immersion treatment, last natural drying, namely make nano-silver testicular prosthesis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102117228A CN102293689B (en) | 2011-07-27 | 2011-07-27 | Nano-silver testicular prosthesis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102117228A CN102293689B (en) | 2011-07-27 | 2011-07-27 | Nano-silver testicular prosthesis |
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|---|---|
| CN102293689A CN102293689A (en) | 2011-12-28 |
| CN102293689B true CN102293689B (en) | 2013-11-20 |
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|---|---|---|---|
| CN2011102117228A Expired - Fee Related CN102293689B (en) | 2011-07-27 | 2011-07-27 | Nano-silver testicular prosthesis |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107773835B (en) * | 2017-11-28 | 2023-01-31 | 无锡市第二人民医院 | Anti-reflux antibacterial catheter and manufacturing method thereof |
| CN109821074B (en) * | 2019-02-28 | 2021-11-26 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | Intelligent children testicular prosthesis based on implanted silica gel |
| CN110664511A (en) * | 2019-10-30 | 2020-01-10 | 安徽奥弗医疗设备科技股份有限公司 | Solid testicular prosthesis and manufacturing method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080177385A1 (en) * | 2007-01-18 | 2008-07-24 | Ams Research Corporation | Testicular Prosthesis |
| CN201668534U (en) * | 2010-05-05 | 2010-12-15 | 上海依红科技工程有限公司 | Spermary prosthesis |
| CN101912638A (en) * | 2010-07-26 | 2010-12-15 | 郭云童 | Nano silver-carrying-silicon dioxide catheter and production method thereof |
| CN101912634B (en) * | 2010-08-06 | 2013-09-25 | 华南理工大学 | Method for preparing nanosilver/nano silicon dioxide-containing antibacterial biological dressing |
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