CN105622460A - Synthesis method for (R)-N-t-BOC biphenyl alaninol - Google Patents
Synthesis method for (R)-N-t-BOC biphenyl alaninol Download PDFInfo
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- 0 CC(C)(C)OC(N[C@@](C*)Cc(cc1)ccc1-c1ccccc1)=O Chemical compound CC(C)(C)OC(N[C@@](C*)Cc(cc1)ccc1-c1ccccc1)=O 0.000 description 2
- TYQICOFAZDVKMK-GOSISDBHSA-N CC(C)(C)OC(N[C@H](Cc(cc1)ccc1-c1ccccc1)CO)=O Chemical compound CC(C)(C)OC(N[C@H](Cc(cc1)ccc1-c1ccccc1)CO)=O TYQICOFAZDVKMK-GOSISDBHSA-N 0.000 description 1
- LNYPSVADYCVBTQ-QFIPXVFZSA-N O[C@@H](Cc(cc1)ccc1-c1ccccc1)COCc1ccccc1 Chemical compound O[C@@H](Cc(cc1)ccc1-c1ccccc1)COCc1ccccc1 LNYPSVADYCVBTQ-QFIPXVFZSA-N 0.000 description 1
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Abstract
The invention discloses a synthesis method for (R)-N-t-BOC biphenyl alaninol.The synthesis method includes the steps that firstly, a compound 1 is obtained through a reaction of 4-bromo biphenyl and (S)-benzyl oxygen methyloxirane; the compound 1 and amine(succinimide and orthophthalic succinimide) are subjected to a Mitsunobu reaction to generate a compound 2, the compound 2 is subjected to an acidolysis reaction to obtain a compound 3, the compound 3 is subjected to an N-Boc reaction to obtain a compound 4, and the compound 4 is subjected to hydrogenolysis to obtain the needed compound 5 (R)-N-t-BOC biphenyl alaninol.The synthesis method has the advantages that side reactions are fewer, reaction conditions are mild, the yield is high, operability is high, product quality is stable, and side products are easy to separate, and is more suitable for industrial production.
Description
Technical field
The method that the present invention relates to the R configuration biphenyl Propanolamine preparing Boc protection, particularly to the synthetic method of a kind of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine.
Background technology
Endogenous atrial natriuretic peptide (ANP), or it is called endogenous atrionatriuretic factor (ANF), there is diuresis, short natruresis and arterial dilation in mammal body. Internal ANF peptide is easily by neutral endopeptidase (enkephalin enzyme, NEP) metabolic inactivation, and enkephalin metabolism also can be inactivated by NEP simultaneously.
In the prior art, the phosphonate derivative of known biaryl substituted can be used as the inhibitor of neutral endopeptidase (NEP), such as the inhibitor of mammal ANF digestive enzyme, extend thus the relatively low metabolite of activity can be degraded to by development ANF and strengthen ANF diuresis in mammal body, natruresis and vasodilation characteristic. Therefore, nep inhibitor can be used for treating the suppression of centering endopeptidase situation and disease, particularly the cardiovascular disorder such as hypertension, renal insufficiency of response, including edema and salt retention, pulmonary edema and congestive heart failure.
(R) structural formula of-N-tertbutyloxycarbonyl biphenyl Propanolamine is:Wherein Boc=tertbutyloxycarbonyl. Should (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine be the key intermediate (see such as EP00590442 and US4722810) in the synthesis of neutral endopeptidase (NEP) inhibitor.
Several method for preparing (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine has been seen in report. But, these methods are all to use the raw material (D-Tyrosine of costliness; J.Med.Chem.1995,38,189) based on or depend on the fractionation (EP1980622) of corresponding racemate, or using and have optically active metal complex to be used as reagent (WO2013026773A1), Financial cost is high; Or synthetic route is loaded down with trivial details, not easily operation (WO2015024991A1). Patent WO2014032627A1 uses raw material epoxychloropropane to participate in grignard reaction; easily carry out the exchange of grignard reagent and coupling side reaction with grignard reagent (namely; it is easily generated the reaction impurities of high-load; therefore reaction yield is low); or use S-tert-butoxy oxirane to participate in grignard reaction as raw material; in subsequent reactions, tert-butoxy not easily deprotection generates target product; accordingly, it would be desirable to a kind of reaction condition of exploitation is gentle, side reaction is few, environmental protection and be suitable for industrial method synthesis (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine.
Summary of the invention
The technical problem to be solved in the present invention is to provide the synthetic method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of a kind of reaction condition gentleness, environmental protection.
In order to solve above-mentioned technical problem, the present invention provides the synthetic method of a kind of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine, is sequentially carried out following steps:
1), the anhydrous tetrahydro furan using magnesium with as solvent is put in reaction bulb, it is warming up to 35��55 DEG C (being preferably 40��45 DEG C) under nitrogen protection, add iodine and bromo biphenyl/tetrahydrofuran solution is prepared grignard reagent by addition, mol ratio to bromo biphenyl Yu magnesium is 1:1��1.5 (being preferably 1:1��1.2), iodine and the weight ratio to bromo biphenyl are 0.1%��0.5%, and the response time is 2��6h (being preferably 2��4h);
Then reaction temperature is reduced extremely-15��0 DEG C (being preferably-15��-5 DEG C), add Hydro-Giene (Water Science)., drip (S)-benzyloxymethyl oxirane/tetrahydrofuran solution again, mol ratio to bromo biphenyl Yu Hydro-Giene (Water Science). is 1:0.1��0.5, mol ratio to bromo biphenyl Yu (S)-benzyloxymethyl oxirane is 1:1��1.5 (being preferably 1:1.1��1.3), response time is 2��6h (being preferably 2��4h), obtains compound 1; The structural formula of this compound 1 is:
Remarks illustrate: grignard reagent is the high activity intermediate preparing compound 1; To bromo biphenyl, i.e. 4-bromo biphenyl; Iodine is catalyst, is also judge the color indicator that reaction starts; To bromo biphenyl/tetrahydrofuran solution, i.e. bromo biphenyl will be dissolved in the solution of oxolane gained; All the other are by that analogy;
2), by compound 1, triphenylphosphine, R1-H and low polar solvent mixing, the mol ratio of compound 1 and triphenylphosphine is 1:1��2 (being preferably 1:1��1.2), compound 1 and R1The mol ratio of-H is 1:1��2 (being preferably 1:1��1.2), controlling reaction temperature under nitrogen protection is-1��15 DEG C, add azoformic acid diester and carry out insulation reaction, the mol ratio of compound 1 and azoformic acid diester is 1:1��2 (being preferably 1:1��1.2), response time is 2��6h (being preferably 2��4h), obtains compound 2; R1-H is succimide, adjacent benzene succimide (phthalimide);
The structural formula of this compound 2 is:
3), using water as solvent, compound 2 reacts under the acid condition that pH is 0.5��1, and reaction temperature is 60��100 DEG C, and the response time is 6��15h (being preferably 6��10h), obtains compound 3; The structural formula of this compound 3 is:
4), using alcohol-water mixture as solvent, with sodium hydroxide for acid binding agent, compound 3 and Bis(tert-butoxycarbonyl)oxide (Boc2O) react, compound 3 and Bis(tert-butoxycarbonyl)oxide (Boc2O) mol ratio is 1:1��2 (being preferably 1:1��1.2), and the mol ratio of compound 3 and sodium hydroxide is 1:1��2.5 (being preferably 1:1.1��1.3); Reaction temperature is 20��60 DEG C, and the response time is 2��6h (being preferably 2��4h), obtains compound 4; The structural formula of this compound 4 is:
5), with alcohol for solvent, H is utilized2Regulating pressure to 0.5��3Mpa (being preferably 1��1.5Mpa), compound 4 reacts after mixing with Pd/C; In described Pd/C, the mass content of Pd is 10%; The mol ratio of the Pd in compound 4 and Pd/C is 1:0.001��0.004 (being preferably 1:0.003��0.004); Reaction temperature is 25��60 DEG C, and the response time is 2��16h (being preferably 2��4h), obtains compound 5; This compound 5 is (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine, and its structural formula is:
The improvement of synthetic method as (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention: described step 2) in:
Described azoformic acid diester is diethyl azodiformate (diethylazodicarboxylate), diisopropyl azodiformate, di tert butyl carbonate;
Low polar solvent is oxolane, ether, dichloromethane, toluene, ethyl acetate, acetonitrile.
The further of synthetic method as (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention is improved:
Described step 4) alcohol-water mixture in, the volume content of water is 20��80%; Described alcohol is methanol or ethanol;
Described step 5) alcohol be methanol or ethanol.
The further of synthetic method as (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention is improved:
Described step 3) in acid used be organic acid or mineral acid, organic acid is formic acid and acetic acid; Mineral acid is hydrochloric acid, sulphuric acid.
The further of synthetic method as (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention is improved:
Step 1) in magnesium be magnesium powder, magnesium chips or magnesium rod.
The further of synthetic method as (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention is improved:
Step 1) in magnesium be preferably the magnesium powder sieve of 200 orders (can cross);
Step 2) in preferable reaction temperature be-1��5 DEG C;
Step 3) in preferable reaction temperature be 80��100 DEG C (being more preferred from 80��90 DEG C);
Step 4) in preferable reaction temperature be 35��60 DEG C;
Step 5) in preferable reaction temperature be 35��40 DEG C.
In the present invention, dropping general control completed in 1��2 hour.
The synthetic method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention, flow chart is as shown in Figure 1. The present invention, by the reaction to bromo biphenyl Yu (S)-benzyloxymethyl oxirane, obtains compound 1; This compound 1 next step there is Mitsunobu reacting generating compound 2 in (succimide, adjacent benzene succimide) with amine, compound 2 obtains compound 3 through acidolysis reaction, compound 3 is obtained by reacting compound 4 through N-Boc, and compound 4 obtains required compound 5---(R)-N-tertbutyloxycarbonyl biphenyl Propanolamine then through hydrogenesis.
In the present invention, employ following abbreviation: Bn=benzyl, DEAD=diethyl azodiformate, Boc=tertbutyloxycarbonyl. R1Title and the structural formula of-H are as shown in the table:
In the present invention,
To step 1) grignard reaction complete after the reactant liquor that generates, the available conventional treatment method process reactant liquor such as extracting, concentrating, or preferably mode be reactant liquor is regulated to acid, wash several times again, then organic phase solution is evaporated to dry, thus obtaining the crude product of compound 1. Above-mentioned crude product can be directly used for following step 2) reaction. This crude product toluene can also be refined, obtain highly purified compound 1; Again highly purified compound 1 is used for following step 2) reaction.
In step 1) in, it is preferable that react in anhydrous tetrahydro furan.
To step 2) Mitsunobu reacted after the reactant liquor that generates, available such as extract, the conventional treatment method of concentration process reactant liquor, or preferably mode be directly thickened to do; Thus obtaining the crude product of compound 2. Above-mentioned crude product can be directly used for following step 3) reaction.
In step 2) in, it is preferable that react in toluene.
To step 3) reacting by heating complete after the reactant liquor that generates, the available conventional treatment method process reactant liquor such as extracting, washing, concentrate, or mode is to wash several times with toluene preferably, then aqueous phase solution is regulated PH to alkalescence, thus precipitating out the crude product obtaining compound 3. Above-mentioned crude product can be directly used for following step 4) reaction.
In step 3) in, it is preferable that react in pure water.
To step 4) reacting by heating complete after the reactant liquor that generates, the available conventional treatment method process reactant liquor such as extracting, washing, concentrate, or mode is directly by the alcoholic solvent evaporated under reduced pressure in reactant liquor preferably, thus crystallizing out the crude product of compound 4 in water. Above-mentioned crude product can be directly used for following step 5) reaction.
In step 4) in, it is preferable that react in 50% ethanol water.
To step 5) reacting by heating complete after the reactant liquor that generates, the available conventional treatment method process reactant liquor such as extracting, washing, concentrate, or mode is directly by reactant liquor evaporated under reduced pressure preferably, thus obtaining the crude product of compound 5, above-mentioned crude product uses crystal's system again, thus obtaining highly purified compound 5.
In step 5) in, it is preferable that react in ethanol.
The synthetic method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention, with to bromo biphenyl and (S)-benzyloxymethyl oxirane for raw material, just can prepare (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine by simple five steps reactions. The preparation method of the present invention does not need based on expensive raw material or depends on the fractionation of corresponding racemate, it is not required that uses and has optically active metal complex to be used as reagent, it is not necessary to use special reagent; And raw material can directly be commercially available, greatly reduce production cost, and the preparation method five step total recovery of the present invention is up to 62.4%.
In sum, the synthetic method of the present invention has the advantages such as side reaction is few, reaction condition is gentle, yield is high, workable, constant product quality, by-product are easily separated, is more suitable for industrialization and produces. The present invention, for WO2014032627A1, improves reaction yield.
Accompanying drawing explanation
Below in conjunction with accompanying drawing, the specific embodiment of the present invention is described in further detail.
Fig. 1 is the flow chart of the synthetic method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention.
Detailed description of the invention
Dropping involved in the step of following case is all completed in 1��2 hour.
For the ease of further appreciating that the present invention, provide below embodiment and it has been done more detailed description. These embodiments are intended for narration and are not for limiting the scope of the present invention or implementation principle.
Embodiment 1, a kind of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine preparation method, be sequentially carried out following steps:
1), the preparation of compound 1:
500ml four-hole boiling flask adds 4.94g (0.21mol) magnesium powder and the anhydrous THF of 88g, stirring; Obtain magnesium/tetrahydrofuran solution.
Separately open one pot of parallel reaction, 250ml flask adds 46.6g4-bromo biphenyl (0.20mol) and the anhydrous THF of 88g, stirring, obtains 4-bromo biphenyl/tetrahydrofuran solution; Standby.
Reaction system (magnesium/tetrahydrofuran solution) heats under nitrogen protection to 40 �� 1 DEG C; under heat-retaining condition; add iodine (0.047g) while stirring to this reaction system and account for 4-bromo biphenyl tetrahydrofuran solution (about 25ml) of total amount 1/4; then; remaining (namely; account for the 3/4 of total amount) 4-bromo biphenyl tetrahydrofuran solution by dropping in the way of add, drip afterwards insulation 2h react. It is cooled to-5 �� 1 DEG C after having reacted, add 3.81g (0.02mol) Hydro-Giene (Water Science)., then keep temperature dropping (S)-benzyloxymethyl oxirane/tetrahydrofuran solution [39.4g (0.24mol) (s)-benzyloxymethyl oxirane is dissolved in 30g oxolane], drip and be incubated 2h afterwards.
The reactant liquor of gained adds 120.4g4MHCl solution, stirring. Then, solution is layered, collected organic layer (is positioned at upper strata), the THF washing of water layer 80ml, with saturated aqueous common salt 100ml washing after the cleaning mixture of gained and organic layer being merged, concentration (in 45 �� 5 DEG C of concentrations until no longer there being new solid to produce), solid filters, filter cake pure water, and vacuum 55-60 DEG C dries, finally obtain yellow powder solid (compound 1) 56.0g, yield 88.2%.
1H-NMR(500MHz,CDCl3, �� ppm): 7.59-7.57 (m, 4H, Ar-H), 7.41 (d, J=9.12Hz, 2H, Ar-H), 7.39 (d, J=9.18Hz, 2H, Ar-H), 7.38-7.34 (m, 3H, Ar-H), 7.32-7.29 (m, 3H, Ar-H), 4.52 (s, 2H, CH2), 4.12-4.11 (m, 1H, CH), 3.58 (d, J=9.33Hz, 2H, CH2), 2.96 (d, J=5.5Hz, 2H, CH2), 2.31 (dd, J=0.6Hz, 1H, OH).
2), the preparation of compound 2-1:
Adding 63.6g (0.20mol) compound 1 and 600g toluene in 1000ml four-hole boiling flask, stirring is until all dissolving. Solution is cooled to 0 �� 1 DEG C under nitrogen protection; add 57.64g (0.22mol) triphenylphosphine and 20.79g (0.22mol) succimide; then at 0 �� 1 DEG C, add diethylazodicarboxylate's solution [40.02g (0.20mol) diethylazodicarboxylate is dissolved in 40g toluene], insulation reaction 2h while stirring.
The reactant liquor of gained is evaporated under reduced pressure and removes toluene, and substrate is directly used in next step. Containing compound 2-1 in this substrate.
1H-NMR(500MHz,CDCl3, �� ppm): 7.71-7.65 (m, 4H, Ar-H), 7.64 (d, J=9.33Hz, 2H, Ar-H), 7.61 (d, J=8.33Hz, 2H, Ar-H), 7.56-7.45 (m, 3H, Ar-H), 7.38-7.31 (m, 3H, Ar-H), 4.72 (s, 2H, CH2), 4.42-4.32 (m, 1H, CH), 3.67 (d, J=10.32Hz, 2H, CH2), 3.05 (d, J=5.8Hz, 2H, CH2),2.73-2.77(m,4H,CH2)��
3), the preparation of compound 3:
300g water adds above-mentioned steps 2) in the substrate that obtains, heating, to 80 �� 1 DEG C, is slowly added to HCl until the pH value of regulation system is 1. Then insulated and stirred 6h.
After the product of gained is cooled to room temperature, add 433g toluene, heating to 80 �� 1 DEG C of stirring 30min, cooling, solution is layered, collect water layer (being positioned at lower floor), the sodium hydrate aqueous solution utilizing concentration to be 30% regulates PH=9-10, precipitates out product, cold filtration, finally obtain white solid (compound 3) 51.3g, yield 81.2%.
1H-NMR(500MHz,CDCl3, �� ppm): 7.77-7.71 (m, 4H, Ar-H), 7.69 (d, J=9.33Hz, 2H, Ar-H), 7.64 (d, J=10.12Hz, 2H, Ar-H), 7.59-7.56 (m, 3H, Ar-H), 7.49-7.45 (m, 3H, Ar-H), 5.11 (d, J=7.2Hz, 2H, NH2),4.38(s,2H,CH2), 4.32-4.22 (m, 1H, CH), 3.46 (d, J=8.12Hz, 2H, CH2), 2.85 (d, J=6.4Hz, 2H, CH2)��
4), the preparation of compound 4:
1000ml four-hole boiling flask adds 63.4g (0.20mol) compound 3,200g water and 160g ethanol, stirring is until dissolving, then, add 9.6g (0.24mol) sodium hydroxide, heating, to 55 �� 1 DEG C, is subsequently adding 48.4g (0.22mol) Bis(tert-butoxycarbonyl)oxide, keeps temperature stirring 2h.
By the reactant liquor vacuum fractionation of gained, until removing all ethanol, then mother solution cooling, precipitate filters, and filter cake washes with water, dries (baking temperature of 55-60 DEG C) in air dry oven, obtain white solid (compound 4) 79.2g, yield 95.2%.
1H-NMR(500MHz,CDCl3, �� ppm): 7.82-7.76 (m, 4H, Ar-H), 7.72 (d, J=9.33Hz, 2H, Ar-H), 7.69 (d, J=10.12Hz, 2H, Ar-H), 7.64-7.58 (m, 3H, Ar-H), 7.52-7.44 (m, 3H, Ar-H), 5.84 (d, J=8.2Hz, 1H, NH), 4.41 (s, 2H, CH2), 4.35-4.32 (m, 1H, CH), 3.72 (d, J=8.12Hz, 2H, CH2), 2.75 (d, J=8.33Hz, 2H, CH2).1.38(s,9H,CH3)��
5), the preparation of compound 5:
Adding 83.4g (0.20mol) compound 4,300g ethanol in 1000ml autoclave, stirring is until dissolving, then, 0.8g10%Pd/C (that is, Pd is 0.0007mol) is added, Hydrogen Vapor Pressure is 1MPa, heats to 45 �� 1 DEG C of maintenance temperature stirring 4h.
By the reacting liquid filtering of gained, filtrate decompression fractional distillation, until removing all ethanol, obtains white solid (compound 5, i.e. (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine) 60.8g, yield 93.0%.
1H-NMR(500MHz,CDCl3, �� ppm): 7.54-7.49 (m, 4H, Ar-H), 7.48 (d, J=9.56Hz, 2H, Ar-H), 7.30-7.24 (m, 3H, Ar-H), 6.04 (d, J=9.12Hz, 1H, NH), 4.72 (d, J=7.2Hz, 1H, OH), 4.24-4.20 (m, 1H, CH), 3.74 (d, J=8.56Hz, 2H, CH2), 2.57 (d, J=4.8Hz, 2H, CH2).1.28(s,9H,CH3)��
Above five step total recoverys are 63.4%.
Embodiment 2, a kind of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine preparation method, be sequentially carried out following steps:
1), the preparation of compound 1:
100ml four-hole boiling flask adds 0.99g (0.041mol) magnesium powder and the anhydrous THF of 18g, stirring; Obtain magnesium/tetrahydrofuran solution.
Separately open one pot of parallel reaction, 50ml flask adds 9.3g4-bromo biphenyl (0.040mol) and the anhydrous THF of 18g, stirring, obtains 4-bromo biphenyl/tetrahydrofuran solution, standby.
Reaction system (magnesium/tetrahydrofuran solution) heats under nitrogen protection to 45 �� 1 DEG C. Under heat-retaining condition, in magnesium/tetrahydrofuran solution, iodine (0.0465g) and account for 4-bromo biphenyl tetrahydrofuran solution (about 5ml) of total amount 1/4 and add while stirring, then, remaining 4-bromo biphenyl tetrahydrofuran solution is (namely, account for the 3/4 of total amount) add in the way of dropping, drip and be incubated 4h afterwards. It is cooled to-14 �� 1 DEG C after having reacted, add 0.76g (0.0040mol) Hydro-Giene (Water Science)., then keep temperature dropping solution [7.9g (0.048mol) (s)-benzyloxymethyl oxirane is dissolved in 6g oxolane], drip and be incubated 4h afterwards.
The reactant liquor of gained adds 24g4MHCl solution, stirring. Then, solution is layered, collected organic layer, and water layer THF washs, saturated common salt water washing is used after the cleaning mixture of gained and organic layer being merged, concentration, solid filters, filter cake pure water, vacuum 55-60 DEG C dries, finally obtains yellow powder solid 10.0g, yield 79%. MS-ESI:319 (M+1,100%).
2), the preparation of compound 2-2:
Adding 10.6g (0.033mol) compound 1 and 100g toluene in 250ml four-hole boiling flask, stirring is until all dissolving. Solution is cooled to 5 �� 1 DEG C under nitrogen protection; add 9.6g (0.036mol) triphenylphosphine and the adjacent benzene succimide of 5.2g (0.036mol); then at 5 �� 1 DEG C, add diethylazodicarboxylate's solution [6.7g (0.033mol) diethylazodicarboxylate is dissolved in 6g toluene], insulation reaction 4h while stirring.
The reactant liquor of gained is evaporated under reduced pressure and removes toluene, and substrate is directly used in next step. Containing compound 2-2 in this substrate.
1H-NMR(500MHz,CDCl3, �� ppm): 7.82-7.80 (m, 2H, Ar-H), 7.78-7.74 (m, 2H, Ar-H), 7.71-7.68 (m, 4H, Ar-H), 7.59 (d, J=9.33Hz, 2H, Ar-H), 7.52 (d, J=10.12Hz, 2H, Ar-H), 7.49-7.45 (m, 3H, Ar-H), 7.42-7.38 (m, 3H, Ar-H), 4.15 (s, 2H, CH2), 3.85-3.82 (m, 1H, CH), 3.64 (d, J=8.42Hz, 2H, CH2), 2.47 (d, J=4.12Hz, 2H, CH2)��
3), the preparation of compound 3:
50g water adds above-mentioned steps 2) in the substrate that obtains, heating to 90 �� 1 DEG C, be slowly added to HCl until regulation system pH value be 1. Then insulated and stirred 10h.
After the product of gained is cooled to room temperature, adding 72.1g toluene, heat to 90 �� 1 DEG C of stirring 30min, cooling, solution is layered, and collects water layer, regulates PH=9-10, precipitation product, cold filtration, finally obtains white solid 7.7g, yield 73.9%. MS-ESI:318 (M+1,100%).
4), the preparation of compound 4:
250ml four-hole boiling flask adds 10.6g (0.033mol) compound 3,30g water and 25g ethanol, stirring is until dissolving, then, add 1.6g (0.040mol) sodium hydroxide, heating, to 35 �� 1 DEG C, is subsequently adding 8.1g (0.037mol) Bis(tert-butoxycarbonyl)oxide, keeps temperature stirring 4h.
By the reactant liquor vacuum fractionation of gained, until removing all ethanol, then mother solution cooling, precipitate filters, and filter cake washes with water, dries, obtain white solid 12.5g, yield 90.2% in air dry oven. MS-ESI:418 (M+1,100%).
5), the preparation of compound 5:
Adding 13.9g (0.033mol) compound 4,50g ethanol in 250ml autoclave, stirring is until dissolving, then, 0.12g10%Pd/C (that is, Pd is 0.00011mol) is added, Hydrogen Vapor Pressure is 1.5MPa, heats to 35 �� 1 DEG C of maintenance temperature stirring 2h.
By the reacting liquid filtering of gained, filtrate decompression fractional distillation, until removing all ethanol, obtains white solid 9.65g, yield 90.0%. MS-ESI:328 (M+1,100%).
Above five step total recoverys are 47.3%.
Embodiment 3, by embodiment 1 step 2) in diethylazodicarboxylate make diisopropyl azodiformate into, mole is constant; All the other are equal to embodiment 1. Five step total recoverys are 57.5%.
Embodiment 4, by embodiment 1 step 2) in diethylazodicarboxylate make di tert butyl carbonate into, mole is constant; All the other are equal to embodiment 1. Five step total recoverys are 65.2%.
Finally, in addition it is also necessary to be only several specific embodiments of the present invention it is noted that listed above. It is clear that the invention is not restricted to above example, it is also possible to there are many deformation. All deformation that those of ordinary skill in the art can directly derive from present disclosure or associate, are all considered as protection scope of the present invention.
Claims (6)
1. the synthetic method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine, is characterized in that being sequentially carried out following steps:
1), the anhydrous tetrahydro furan using magnesium with as solvent is put in reaction bulb, it is warming up to 35��55 DEG C under nitrogen protection, add iodine and bromo biphenyl/tetrahydrofuran solution is prepared grignard reagent by addition, mol ratio to bromo biphenyl Yu magnesium is 1:1��1.5, iodine and the weight ratio to bromo biphenyl are 0.1%��0.5%, and the response time is 2��6h;
Then reaction temperature is reduced to-15��0 DEG C, add Hydro-Giene (Water Science)., drip (S)-benzyloxymethyl oxirane/tetrahydrofuran solution again, mol ratio to bromo biphenyl Yu Hydro-Giene (Water Science). is 1:0.1��0.5, mol ratio to bromo biphenyl Yu (S)-benzyloxymethyl oxirane is 1:1��1.5, response time is 2��6h, obtains compound 1; The structural formula of this compound 1 is:
2), by compound 1, triphenylphosphine, R1-H and low polar solvent mixing, the mol ratio of compound 1 and triphenylphosphine is 1:1��2, compound 1 and R1The mol ratio of-H is 1:1��2, and controlling reaction temperature under nitrogen protection is-1��15 DEG C, adds azoformic acid diester and carries out insulation reaction, and the mol ratio of compound 1 and azoformic acid diester is 1:1��2, and the response time is 2��6h, obtains compound 2; R1-H is succimide, adjacent benzene succimide;
The structural formula of this compound 2 is:
3), using water as solvent, compound 2 reacts under the acid condition that pH is 0.5��1, and reaction temperature is 60��100 DEG C, and the response time is 6��15h, obtains compound 3; The structural formula of this compound 3 is:
4), using alcohol-water mixture as solvent, with sodium hydroxide for acid binding agent, compound 3 and Bis(tert-butoxycarbonyl)oxide react, and the mol ratio of compound 3 and Bis(tert-butoxycarbonyl)oxide is 1:1��2, and the mol ratio of compound 3 and sodium hydroxide is 1:1��2.5; Reaction temperature is 20��60 DEG C, and the response time is 2��6h, obtains compound 4; The structural formula of this compound 4 is:
5), with alcohol for solvent, H is utilized2Regulating pressure to 0.5��3Mpa, compound 4 reacts after mixing with Pd/C; In described Pd/C, the mass content of Pd is 10%; The mol ratio of the Pd in compound 4 and Pd/C is 1:0.001��0.004; Reaction temperature is 25��60 DEG C, and the response time is 2��16h, obtains compound 5; This compound 5 is (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine, and its structural formula is:
2. the synthetic method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine according to claim 1, is characterized in that:
Described step 2) in:
Described azoformic acid diester is diethyl azodiformate, diisopropyl azodiformate, di tert butyl carbonate;
Low polar solvent is oxolane, ether, dichloromethane, toluene, ethyl acetate, acetonitrile.
3. the synthetic method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine according to claim 2, is characterized in that:
Described step 4) alcohol-water mixture in, the volume content of water is 20��80%; Described alcohol is methanol or ethanol;
Described step 5) alcohol be methanol or ethanol.
4. the synthetic method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine according to claim 2, is characterized in that:
Described step 3) in acid used be organic acid or mineral acid, organic acid is formic acid and acetic acid; Mineral acid is hydrochloric acid, sulphuric acid.
5. the synthetic method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine according to claim 2, is characterized in that:
Step 1) in magnesium be magnesium powder, magnesium chips or magnesium rod.
6. the synthetic method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine according to claim 2, is characterized in that:
Step 1) in magnesium be preferably magnesium powder;
Step 2) in preferable reaction temperature be-1��5 DEG C;
Step 3) in preferable reaction temperature be 80��100 DEG C;
Step 4) in preferable reaction temperature be 35��60 DEG C;
Step 5) in preferable reaction temperature be 35��40 DEG C.
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| US3462483A (en) * | 1964-07-23 | 1969-08-19 | British Drug Houses Ltd | Novel derivatives of 3-hydroxy-4-phenyl-butyric acid |
| CN85101902A (en) * | 1983-10-03 | 1987-01-17 | E·R·斯奎布父子公司 | Enkephalinase inhibitor |
| CN101370943A (en) * | 2006-01-17 | 2009-02-18 | 住友化学株式会社 | Production method of optically active biphenyl alanine compound or salt thereof and ester thereof |
| CN103764624A (en) * | 2011-08-19 | 2014-04-30 | 帝斯曼知识产权资产管理有限公司 | Synthesis of R-biphenylalaninol |
| CN105026361A (en) * | 2012-08-31 | 2015-11-04 | 浙江九洲药业股份有限公司 | New process |
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| US4722810A (en) * | 1984-08-16 | 1988-02-02 | E. R. Squibb & Sons, Inc. | Enkephalinase inhibitors |
| CN105017082B (en) * | 2015-07-31 | 2017-09-19 | 上海皓元医药股份有限公司 | A kind of preparation method of heart failure medicine Entresto key intermediates (R) tert-butyl group (base of 1 ([1,1` biphenyl] 4 bases) 3 hydroxy propane 2) carbamate |
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| CN85101902A (en) * | 1983-10-03 | 1987-01-17 | E·R·斯奎布父子公司 | Enkephalinase inhibitor |
| CN101370943A (en) * | 2006-01-17 | 2009-02-18 | 住友化学株式会社 | Production method of optically active biphenyl alanine compound or salt thereof and ester thereof |
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