CN105585511A - Preparation method of (R)-N-t-butyloxycarboryl biphenyl alaninol - Google Patents
Preparation method of (R)-N-t-butyloxycarboryl biphenyl alaninol Download PDFInfo
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- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Abstract
The invention discloses a preparation method of (R)-N-t-butyloxycarboryl biphenyl alaninol. The preparation method comprises the following steps: generating a compound 1 from bromobiphenyl and (S)-benzyloxymethyl oxacyclopropanel; mixing the compound 1, triphenylphosphine, R2-H and a low-polarity solvent to react, so as to obtain a substrate containing a compound 6, wherein R2-H is N-(t-butyloxycarboryl)-p-toluene sulfonamide, or dimethyl benzyl tert-butyl imide; and carrying out subsequent reaction on the substrate containing the compound 6, so as to finally obtain (R)-N-t-butyloxycarboryl biphenyl alaninol. The preparation method has the advantages that side reactions are few, reaction conditions are mild, the yield is high, the operability is strong, the product stability is stable, by-products are easily separated, and the like; and the preparation method is more applicable to industrial production.
Description
Technical field
The present invention relates to the method for the R configuration biphenyl Propanolamine of preparing Boc protection, the particularly tertiary fourth oxygen of one (R)-N-The preparation method of carbonyl biphenyl Propanolamine.
Background technology
Endogenous ANP (ANP), or be called endogenous atrionatriuretic factor (ANF), tool in mammalian bodyThere are diuresis, short natruresis and arterial dilation. ANF peptide in body is easily by neutral endopeptidase (enkephalin enzyme, NEP)Metabolic inactivation, NEP also can be by enkephalins metabolic inactivation simultaneously.
In the prior art, the phosphonate derivative of known biaryl substituted can be used as pressing down of neutral endopeptidase (NEP)Preparation, for example, as the inhibitor of mammal ANF digestive enzyme, thereby can be degraded to active lower metabolism by development ANFProduct extends and strengthens diuresis, natruresis and the vasodilation characteristic of ANF in mammalian body. Therefore, nep inhibitorSituation and the illness, particularly cardiovascular disorder that the inhibition that can be used for treating centering endopeptidase has a response as hypertension,Renal insufficiency, comprises oedema and salt retention, pulmonary edema and congestive heart failure.
(R) structural formula of-N-tertbutyloxycarbonyl biphenyl Propanolamine is:Wherein uncle Boc=Butoxy carbonyl. Should (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine be in the middle of the key during neutral endopeptidase (NEP) inhibitor synthesizesBody (seeing for example EP00590442 and US4722810).
Several method for the preparation of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine has been seen in report. But, these methodsAll to use expensive raw material (D-Tyrosine; J.Med.Chem.1995,38,189) disappear for basis or outside depending on accordinglyRevolve the fractionation (EP1980622) of ester, or use have optically active metal complex to be used as reagent (WO2013026773A1),Financial cost is high; Or synthetic route is loaded down with trivial details, (WO2015024991A1) not easy to operate. Patent WO2014032627A1 uses raw materialEpoxychloropropane participates in grignard reaction, easily and grignard reagent carry out the exchange of grignard reagent and coupling side reaction (, easily produce highThe reaction impurities of content, therefore reaction yield is low), or it is anti-to participate in form with S-tert-butoxy oxirane as raw materialShould, in subsequent reactions, tert-butoxy is difficult for deprotection generation target product, therefore, need to develop a kind of reaction condition gentleness, pairReaction less, environmental protection and be applicable to synthetic (the R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of industrial method.
Summary of the invention
The technical problem to be solved in the present invention is to provide that a kind of reaction condition gentleness, side reaction are few, (R) of environmental protection-The preparation method of N-tertbutyloxycarbonyl biphenyl Propanolamine.
In order to solve the problems of the technologies described above, the invention provides the preparation side of one (R)-N-tertbutyloxycarbonyl biphenyl PropanolamineMethod, carry out successively following steps:
1), put in reaction bulb using magnesium with as the anhydrous tetrahydro furan of solvent, under nitrogen protection, be warming up to 35～55 DEG C, add iodine and add bromo biphenyl/tetrahydrofuran solution is prepared to grignard reagent, be 1 to the mol ratio of bromo biphenyl and magnesium:1～1.5 (being preferably 1:1～1.1), iodine be 0.1%～0.5% to the weight ratio of bromo biphenyl, the reaction time is 2～6h;
Then reduce reaction temperature to-15～0 DEG C, add cuprous iodide, then drip (S)-benzyloxymethyl oxirane/tetra-Hydrogen furans solution, is 1:0.1～0.5 to the mol ratio of bromo biphenyl and cuprous iodide, to bromo biphenyl and (S)-benzyloxymethyl epoxyThe mol ratio of ethane is 1:1～1.5 (being preferably 1:1.1～1.2), and the reaction time is 2～6h, obtains compound 1; This compound1 structural formula is:
Remarks explanation: grignard reagent is the high activity intermediate of preparing compound 1; To bromo biphenyl, that is, and 4-bromo biphenyl; IodineBeing catalyst, is also the color indicator that judgement reaction starts; To bromo biphenyl/tetrahydrofuran solution, that is, will be dissolved in bromo biphenylThe solution of oxolane gained; All the other by that analogy;
2), by compound 1, triphenylphosphine, R2-H and low polar solvent mix, the mol ratio of compound 1 and triphenylphosphineFor 1:1～2 (being preferably 1:1.1～1.2), compound 1 and R2The mol ratio of-H is 1:1～2 (being preferably 1:1.1～1.2),Under nitrogen protection, control reaction temperature and be-1～15 DEG C, then add azoformic acid diester to carry out insulation reaction, compound 1 and evenThe mol ratio of nitrogen dicarboxylate is 1:1～2, and the reaction time is 2～6h, and it is molten that gained reactant liquor reduction vaporization is removed low polarityAgent, obtains the substrate (substrate is directly used in next step reaction) that contains compound 6; R2-H is N-(tertbutyloxycarbonyl)-to tolueneSulfonamide, benzyl tert-butyl group acid imide dimethyl ester;
The structural formula of this compound 6 is:
3), work as R2When-H is N-(tertbutyloxycarbonyl)-para toluene sulfonamide, using alcohol as solvent, by step 2) gained is completeThe substrate that contains compound 6 of portion and Mg (as reaction auxiliary material, de-Ts group) are heated to 20～70 DEG C and react, reactionTime is 2～15h; The mol ratio of described Mg and compound 1 is 4～5:1; Obtain compound 4, the structural formula of this compound 4 is:
Work as R2When-H is benzyl tert-butyl group imines dimethyl ester, using alcohol as solvent, by step 2) gained contain compound 6Substrate stir 2～15h, gained reactant liquor directly carries out following step;
Remarks explanation: when R2-H is benzyl tert-butyl group acid imide dimethyl ester, compound 4 is centres for its reactionState, just purifying does not obtain, and directly carries out the next step;
4), taking alcohol as solvent, utilize H2Regulate pressure to 0.5～3Mpa (being preferably 2～3Mpa), step 3) gained completeAfter mixing with Pd/C, portion's reactant liquor or compound 4 react; In described Pd/C, the mass content of Pd is 10%; Compound 4With the mol ratio of the Pd in Pd/C be 1:0.001～0.004 (being preferably 1:0.003～0.004), or, step 3) in changeThe mol ratio of Pd in compound 6 and Pd/C is 1:0.006～0.008; Reaction temperature is 25～60 DEG C, and the reaction time is 2～16h(being preferably 12～14 hours), obtains compound 5; This compound 5 is (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine, its structural formulaFor:
Improvement as the preparation method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention:
Described step 2) in,
Azoformic acid diester is diethyl azodiformate, diisopropyl azodiformate, di tert butyl carbonate;
Low polar solvent is oxolane, ether, carrene, toluene, ethyl acetate, acetonitrile.
Further improvement as the preparation method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention:
Described step 3) and step 4) in alcohol be methyl alcohol or ethanol.
Further improvement as the preparation method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention:
Step 1) in magnesium be magnesium powder, magnesium chips or magnesium rod.
Further improvement as the preparation method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention:
Step 1) in magnesium be preferably magnesium powder (can cross 200 objects sieve);
Work as R2When-H is N-(tertbutyloxycarbonyl)-para toluene sulfonamide, step 3) in reaction temperature be 40～60 DEG C;
Step 4) in reaction temperature be 50～60 DEG C.
In the present invention, drip general control completed in 1～2 hour.
The preparation method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention, to the nucleophilic in Mitsunobu reactionReagent is optimized screening, obtains the synthetic route that yield is higher, and flow chart as shown in Figure 1.
In the present invention, use following abbreviation: Bn=benzyl, DEAD=diethyl azodiformate, the tertiary fourth oxygen of Boc=Carbonyl. R2Title and the structural formula of-H are as shown in the table:
In the present invention,
To step 1) the reactant liquor that generates after completing of grignard reaction, available such as extraction, concentrated conventional treatment sideMethod processing reaction liquid, or mode is that reactant liquor is adjusted to acidity, washes several times again, then by organic phase solution preferablyBe evaporated to dry, thereby obtain the crude product of compound 1 (formula 1). Above-mentioned crude product can be directly used in following step 2) reaction. AlsoCan this crude product is refining with toluene, obtain highly purified compound 1; Again by highly purified compound 1 for following step 2)Reaction.
In step 1) in, preferably in anhydrous tetrahydro furan, react.
To step 2) Mitsunobu reacted rear generated reactant liquor, available such as extraction, concentrated routine placeReason method processing reaction liquid, or preferably mode be directly concentrated into dry; Thereby obtain the crude product of compound 6. Above-mentioned chemical combinationThe crude product of thing 6 can be directly used in following step 3) reaction.
In step 2) in, preferably in toluene, react.
To step 3) add the reactant liquor generating after thermal response completes, available such as extraction, washing, concentrated routine placeReason method processing reaction liquid, or preferably mode is to be directly concentrated into dryly, with toluene recrystallization, obtains compound thereby separate out4 crude product. The crude product of reactant liquor, compound 4 can be directly used in following step 4) reaction.
In step 3) in, preferably in ethanol, react.
To step 4) add the reactant liquor generating after thermal response completes, available such as extraction, washing, concentrated routine placeReason method processing reaction liquid, or preferably mode is directly by evaporated under reduced pressure after reacting liquid filtering, thus compound 5 obtainedCrude product, above-mentioned crude product again water is refining, thereby obtains highly purified compound 5.
In step 4) in, preferably in ethanol, react.
In the present invention, R2-H adopts N-(tertbutyloxycarbonyl)-para toluene sulfonamide, benzyl tert-butyl group acid imide dimethyl esterDeng, advantage is that yield raising and product and byproduct of reaction triphenylphosphinc oxide are easily separated thoroughly.
The preparation method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine of the present invention, with to bromo biphenyl and (S)-benzyloxymethyl ringOxidative ethane is raw material, just can make (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine by simple four-step reaction. System of the present inventionIt is basis or the fractionation that depends on corresponding racemate that standby method does not need expensive raw material, and also not needing to use has optics to liveThe metal complex of property is used as reagent, does not need to use special reagent, and raw material can directly buy and obtain, and greatly reduces lifeProduce cost, and preparation method of the present invention four step total recoverys can reach 72.8%.
In sum, preparation method of the present invention have that side reaction is few, reaction condition is gentle, yield is high, workable, produceThe advantages such as product steady quality, accessory substance are easily separated, are more suitable for industrialization and produce.
Brief description of the drawings
Below in conjunction with accompanying drawing, the specific embodiment of the present invention is described in further detail.
Fig. 1 is the preparation flow figure of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine.
Detailed description of the invention
In the step of following case, related dropping is all to complete in 1～2 hour.
For the ease of to further understanding of the present invention, provide embodiment to do more detailed description to it below. TheseEmbodiment only is not used for limiting the scope of the invention or implementation principle for narration.
The preparation method of embodiment 1, a kind of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine, carries out following steps successively:
1), the preparation of compound 1:
In 50ml four-hole boiling flask, add 5g magnesium powder (0.21mol) and the anhydrous THF of 90g, stir; Obtain magnesium/tetrahydrofuran solution.
Separately open one pot of parallel reaction, in flask, add 46g4-bromo biphenyl (0.20mol) and the anhydrous THF of 90g, stir,Obtain 4-bromo biphenyl/tetrahydrofuran solution; For subsequent use.
Reaction system (magnesium/tetrahydrofuran solution) is heated to 54 ± 1 DEG C under nitrogen protection. Under heat-retaining condition, to magnesium/tetra-In hydrogen furans solution, iodine (0.046g) and 4-bromo biphenyl/tetrahydrofuran solution (, about 25ml) of accounting for total amount 1/4 are while stirringAdd, then, remaining (that is, and account for total amount 3/4) 4-bromo biphenyl/tetrahydrofuran solution with drip mode add, dripBe incubated afterwards 6h, after having reacted, be cooled to-14 ± 1 DEG C, add 3.8g (0.020mol) cuprous iodide, then keep temperature to dripAdd solution [39g (0.24mol) (s)-benzyloxymethyl oxirane be dissolved in 30g oxolane], after dripping, be incubated 6h.
In the reactant liquor of gained, add 120g4MHCl solution, stir. Then, solution layering, collected organic layer (is positioned atUpper strata), the THF washing of 80ml for water layer, merges the rear saturated aqueous common salt 100ml washing of using by cleaning solution and organic layer, concentrated (in45 ± 5 DEG C are concentrated until no longer include new solid generation), solid filtering, filter cake washs with pure water, and vacuum 55-60 DEG C is dry,After obtain yellow powder solid (compound 1) 58.0g, yield 92.7%. MS-ESI:319 (M+1,100%).
1H-NMR(500MHz,CDCl3,δppm):7.59-7.57(m,4H,Ar-H),7.41(d,J＝9.12Hz,2H,Ar-H),7.39(d,J＝9.18Hz,2H,Ar-H),7.38-7.34(m,3H,Ar-H),7.32-7.29(m,3H,Ar-H),4.52(s,2H,CH2),4.12-4.11(m,1H,CH),3.58(d,J＝9.33Hz,2H,CH2),2.96(d,J＝5.5Hz,2H,CH2),2.31(dd,J＝0.6Hz,1H,OH)。
2), the preparation of compound 6-1:
In 100ml four-hole boiling flask, add 6.3g (0.020mol) compound 1 and 60g toluene, stir until all dissolve. ?Under nitrogen protection, solution is cooled to 14 ± 1 DEG C, adds 5.7g (0.022mol) triphenylphosphine and 5.7g (0.022mol) N-(tertiary fourthOxygen carbonyl)-para toluene sulfonamide, then at 15 ± 1 DEG C, add while stirring solution [4g (0.020mol) azo-2-carboxylic acid twoEthyl ester is dissolved in 4g toluene], insulation reaction 6h.
The reactant liquor reduction vaporization of gained is removed toluene, and substrate is directly used in next step. In this substrate, contain compound 6-1。
1H-NMR(500MHz,CDCl3,δppm):7.92-7.87(m,2H,Ar-H),7.85-7.82(m,4H,Ar-H),7.78(d,J＝9.33Hz,2H,Ar-H),7.71(d,J＝9.56Hz,2H,Ar-H),7.68-7.65(m,3H,Ar-H),7.57-7.52(m,2H,Ar-H),7.50-7.45(m,3H,Ar-H),4.41(s,2H,CH2),3.98-3.95(m,1H,CH),3.34(d,J＝10.24Hz,2H,CH2),3.12(d,J＝4.8Hz,2H,CH2),2.24(s,3H,CH3),1.28(s,9H,CH3)。
3), the preparation of compound 4:
30g methyl alcohol adds above-mentioned steps 2) in whole substrate of obtaining, add 2.4g (0.10mol) Mg, be heated to40 ± 1 DEG C, insulated and stirred 2h is until raw material reaction is complete.
The reactant liquor of gained is cooled to after room temperature, and concentrated (thickening temperatures of 30 ± 5 DEG C), to dry, add 30ml ammonium chloride waterSolution (concentration is 20%) washing, then adds 43g toluene, is heated to 80 ± 1 DEG C and stirs 30min, is then cooled to 60 ± 1DEG C, solution layering, anhydrous magnesium sulfate drying for organic layer (being positioned at upper strata), with toluene recrystallization, obtains white solid (compound4) 7.3g, yield 88.1%. MS-ESI:418 (M+1,100%).
1H-NMR(500MHz,CDCl3,δppm):7.82-7.76(m,4H,Ar-H),7.72(d,J＝9.33Hz,2H,Ar-H),7.69(d,J＝10.12Hz,2H,Ar-H),7.64-7.58(m,3H,Ar-H),7.52-7.44(m,3H,Ar-H),5.84(d,J＝8.2Hz,1H,NH),4.41(s,2H,CH2),4.35-4.32(m,1H,CH),3.72(d,J＝8.12Hz,2H,CH2),2.75(d,J＝8.33Hz,2H,CH2).1.38(s,9H,CH3)。
4), the preparation of compound 5:
In 100ml autoclave, add 8.3g (0.020mol) compound 4,30g ethanol, stirs until then dissolving, addsEnter 0.08g10%Pd/C (that is, Pd is 0.000075mol), Hydrogen Vapor Pressure is 2MPa, is heated to 55 ± 1 DEG C and keeps temperature to stir12h。
By the reacting liquid filtering of gained, filtrate decompression fractionation is until remove all ethanol, obtain white solid (compound 5,That is, (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine) 5.8g, yield 89.2%. MS-ESI:328 (M+1,100%).
1H-NMR(500MHz,CDCl3,δppm):7.54-7.49(m,4H,Ar-H),7.48(d,J＝9.56Hz,2H,Ar-H),7.30-7.24(m,3H,Ar-H),6.04(d,J＝9.12Hz,1H,NH),4.72(d,J＝7.2Hz,1H,OH),4.24-4.20(m,1H,CH),3.74(d,J＝8.56Hz,2H,CH2),2.57(d,J＝4.8Hz,2H,CH2).1.28(s,9H,CH3).
Above four step total recoverys are 72.8%.
The preparation method of embodiment 2, a kind of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine, carries out following steps successively:
1), the preparation of compound 1:
In 50ml four-hole boiling flask, add 0.5g (0.021mol) magnesium powder and the anhydrous THF of 9g, stir, obtain magnesium/oxolane moltenLiquid.
Separately open one pot of parallel reaction, in flask, add 4.6g4-bromo biphenyl (0.020mol) and the anhydrous THF of 9g, stir,Obtain 4-bromo biphenyl/tetrahydrofuran solution; For subsequent use.
Reaction system (magnesium/tetrahydrofuran solution) is heated to 54 ± 1 DEG C under nitrogen protection. Under heat-retaining condition, to magnesium/tetra-In hydrogen furans solution, iodine (0.023g) and the 4-bromo biphenyl tetrahydrofuran solution (, about 2.5ml) that accounts for total amount 1/4 are while stirringAdd, then, remaining 4-bromo biphenyl tetrahydrofuran solution (that is, and account for total amount 3/4) add in the mode dripping, drip itRear insulation 6h, is cooled to-14 ± 1 DEG C after having reacted, and adds 0.38g (0.0020mol) cuprous iodide, then keeps temperature to dripAdd solution [3.9g (0.024mol) (s)-benzyloxymethyl oxirane be dissolved in 3g oxolane], after dripping, be incubated 6h.
In the reactant liquor of gained, add 12g4MHCl solution, stir. Then, solution layering, collected organic layer, water layer is usedTHF washing, merges the rear saturated common salt water washing of using by the cleaning solution of gained and organic layer, concentrated, solid filtering, filter cake pure waterWashing, vacuum 55-60 DEG C dry, finally obtains yellow powder solid 5.6g, yield 89.5%. MS-ESI:319 (M+1,100％)。
2), the preparation of compound 6-2:
In 100ml four-hole boiling flask, add 6.3g (0.020mol) compound 1 and 60g toluene, stir until all dissolve. ?Under nitrogen protection, solution is cooled to 14 ± 1 DEG C, adds 5.7g (0.022mol) triphenylphosphine and 5.3g (0.022mol) benzyl uncleButyl imines dimethyl ester, (4g (0.020mol) diethylazodicarboxylate is molten then at 15 ± 1 DEG C, to add while stirring solutionIn 4g toluene), insulation reaction 6h.
45 ± 5 DEG C of the reactant liquor reduction vaporizations of gained are removed toluene, and substrate is directly used in next step. Containing in this substrateCompound 6-2.
1H-NMR(500MHz,CDCl3,δppm):7.88-7.85(m,4H,Ar-H),7.81(d,J＝8.7Hz,2H,Ar-H),7.79(d,J＝9.6Hz,2H,Ar-H),7.71(d,J＝9.3Hz,2H,Ar-H),7.69-7.66(m,3H,Ar-H),7.61-7.58(m,3H,Ar-H),7.54-7.46(m,3H,Ar-H),4.87(s,2H,CH2),4.41(s,2H,CH2),4.08-4.02(m,1H,CH),3.22(d,J＝9.8Hz,2H,CH2),2.81(d,J＝5.2Hz,2H,CH2),1.18(s,9H,CH3).
3), the preparation of compound 5:
In 100ml autoclave, add above-mentioned steps 2) substrate of gained (approximately containing 0.015mol compound 6-2), 30g secondAlcohol, 20 DEG C stir 2 hours until dissolve,
Then, add 0.12g10%Pd/C (that is, Pd is 0.00011mol), Hydrogen Vapor Pressure is 2MPa, is heated to 55 ± 1DEG C keep temperature to stir 12h, then filter, filtrate decompression fractionation until remove all ethanol, by re-crystallizing in ethyl acetate, obtainsWhite solid (compound 5, that is, (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine) 5.8g, yield 79%. MS-ESI:328 (M+1,100％)。
Above three step total recoverys are 70.7%.
Embodiment 1-1, by embodiment 1 step 2) in diethylazodicarboxylate make diisopropyl azodiformate into,Mole is constant; All the other are equal to embodiment 1.
Four step total recoverys are 71.2%.
Embodiment 1-2, by embodiment 1 step 2) in diethylazodicarboxylate make di tert butyl carbonate into, mole is constant;All the other are equal to embodiment 1.
Four step total recoverys are 69.1%.
Embodiment 2-1, by embodiment 2 steps 2) in diethylazodicarboxylate make diisopropyl azodiformate into,Mole is constant; All the other are equal to embodiment 2.
Three step total recoverys are 68.5%.
Embodiment 2-2, by embodiment 2 steps 2) in diethylazodicarboxylate make di tert butyl carbonate into, mole is constant;All the other are equal to embodiment 2.
Three step total recoverys are 64.8%.
Finally, it is also to be noted that, what more than enumerate is only several specific embodiments of the present invention. Obviously, thisBrightly be not limited to above embodiment, can also have many distortion. Those of ordinary skill in the art can be from content disclosed by the inventionAll distortion of directly deriving or associating, all should think protection scope of the present invention.
Claims (5)
1. the preparation method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine, is characterized in that carrying out successively following steps:
1), put in reaction bulb using magnesium with as the anhydrous tetrahydro furan of solvent, under nitrogen protection, be warming up to 35～55 DEG C,Add iodine and add bromo biphenyl/tetrahydrofuran solution is prepared to grignard reagent, to the mol ratio of bromo biphenyl and magnesium be 1:1～1.5, iodine be 0.1%～0.5% to the weight ratio of bromo biphenyl, the reaction time is 2～6h;
Then reduce reaction temperature to-15～0 DEG C, add cuprous iodide, then drip (S)-benzyloxymethyl oxirane/tetrahydrochysene furanThe solution of muttering, is 1:0.1～0.5 to the mol ratio of bromo biphenyl and cuprous iodide, to bromo biphenyl and (S)-benzyloxymethyl oxiraneMol ratio be 1:1～1.5, the reaction time is 2～6h, obtains compound 1; The structural formula of this compound 1 is:
2), by compound 1, triphenylphosphine, R2-H and low polar solvent mix, and compound 1 is 1:1 with the mol ratio of triphenylphosphine～2, compound 1 and R2The mol ratio of-H is 1:1～2, controls reaction temperature and is-1～15 DEG C, then add idol under nitrogen protectionNitrogen dicarboxylate carries out insulation reaction, and the mol ratio of compound 1 and azoformic acid diester is 1:1～2, and the reaction time is 2～6h, gained reactant liquor reduction vaporization is removed low polar solvent, obtains the substrate that contains compound 6; R2-H is N-(tertiary butyloxycarbonylBase)-para toluene sulfonamide, benzyl tert-butyl group acid imide dimethyl ester;
The structural formula of this compound 6 is:
3), work as R2When-H is N-(tertbutyloxycarbonyl)-para toluene sulfonamide, using alcohol as solvent, by step 2) whole the containing of gainedHave the substrate of compound 6 and Mg to be heated to 20～70 DEG C and react, the reaction time is 2～15h; Described Mg and compound 1Mol ratio be 4～5:1; Obtain compound 4, the structural formula of this compound 4 is:
Work as R2When-H is benzyl tert-butyl group imines dimethyl ester, using alcohol as solvent, by step 2) end of containing compound 6 of gainedThing stirs 2～15h, and gained reactant liquor directly carries out following step;
4), taking alcohol as solvent, utilize H2Regulate pressure to 0.5～3Mpa, step 3) total overall reaction liquid or the compound 4 of gainedAfter mixing with Pd/C, react; In described Pd/C, the mass content of Pd is 10%; The mol ratio of Pd in compound 4 and Pd/CFor 1:0.001～0.004, or, step 3) in compound 6 and Pd/C in the mol ratio of Pd be 1:0.006～0.008;Reaction temperature is 25～60 DEG C, and the reaction time is 2～16h, obtains compound 5; This compound 5 is (R)-N-tertbutyloxycarbonyl connectionPhenylalaninol, its structural formula is:
2. the preparation method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine according to claim 1, is characterized in that:
Described step 2) in,
Azoformic acid diester is diethyl azodiformate, diisopropyl azodiformate, di tert butyl carbonate;
Low polar solvent is oxolane, ether, carrene, toluene, ethyl acetate, acetonitrile.
3. the preparation method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine according to claim 2, is characterized in that:
Described step 3) and step 4) in alcohol be methyl alcohol or ethanol.
4. the preparation method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine according to claim 2, is characterized in that:
Step 1) in magnesium be magnesium powder, magnesium chips or magnesium rod.
5. the preparation method of (R)-N-tertbutyloxycarbonyl biphenyl Propanolamine according to claim 2, is characterized in that:
Step 1) in magnesium be magnesium powder;
Work as R2When-H is N-(tertbutyloxycarbonyl)-para toluene sulfonamide, step 3) in reaction temperature be 40～60 DEG C;
Step 4) in reaction temperature be 50～60 DEG C.
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| CN116535324A (en) * | 2023-07-07 | 2023-08-04 | 广东嘉博制药有限公司 | Preparation method of threo-configuration methoxamine hydrochloride |
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