CN105617109A - 用于治疗慢性咽炎的药物组合物 - Google Patents

用于治疗慢性咽炎的药物组合物 Download PDF

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CN105617109A
CN105617109A CN201610128811.9A CN201610128811A CN105617109A CN 105617109 A CN105617109 A CN 105617109A CN 201610128811 A CN201610128811 A CN 201610128811A CN 105617109 A CN105617109 A CN 105617109A
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徐艳阳
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Abstract

本发明涉及一种用于治疗慢性咽炎的药物组合物，其经由以下步骤制作而成：(1)取厚朴20份、枳实20份、香附6份、桔梗15份、陈皮15份、茯苓12份、半夏9份、苏子12份、甘草6份、沉香3份、柴胡12份、竹茹15份、薄荷12份，经混合、水洗、干燥后形成中药组方，水洗后的水经过滤后形成煎煮用水；(2)将步骤1中的中药组方加入煎煮用水中浸泡2小时，然后文火煮沸30min，倒出药液，再次加入煎煮用水文火煮沸30min，倒出药液，第三次加入煎煮用水文火煮沸30min，倒出药液，将三次药液混合均匀、过滤形成元汤；(3)将步骤2中的元汤中加入蜂胶、甲基纤维素和蔗糖溶液，混合均匀后文火熬制成粘稠膏体。本发明的药物组合物以“气”为核心，有升有降，兼顾肺、肝、脾，使气机调畅，用于治疗慢性咽炎引起的喉中异物感、干咳不止，疗效甚佳，不易复发。

Description

用于治疗慢性咽炎的药物组合物
技术领域
本发明申请涉及一种基于中药组方的药物组合物，特别涉及一种可用于治疗慢性咽炎的药物组合物。
背景技术
咽炎作为一种常见的上呼吸道疾病，发病率极高，分为急性咽炎和慢性咽炎。急性咽炎如不能及时治疗，往往会发展成慢性咽炎，症状主要表为咽部黏膜慢性充血，咽部有异物感、干燥感，可有咳嗽、恶心等。随着近年来空气质量的恶化，咽炎发病率有大幅攀升的趋势，发病以成年人居多，症状反复、病程长，往往给发病者的生活质量造成严重困扰。
针对慢性咽炎，目前西医疗法主要使用抗生素、抗菌素等药物对症状进行缓解、抑制，治标不治本，病情极易出现反复，且药物副作用较大。中医疗法主要有各种口服液、中药汤剂等，但由于见效较慢加上患者服用不方便，多数患者难以长期坚持按时服药，因此往往治疗半途而废。
发明内容
针对上述现有技术的需求及不足之处，本发明提供一种服用方便、疗效好的用于治疗慢性咽炎的药物组合物。具体技术方案如下：
一种用于治疗慢性咽炎的药物组合物，其经由以下步骤制作而成：(1)取厚朴20份、枳实20份、香附6份、桔梗15份、陈皮15份、茯苓12份、半夏9份、苏子12份、甘草6份、沉香3份、柴胡12份、竹茹15份、薄荷12份，经混合、水洗、干燥后形成中药组方，水洗后的水经过滤后形成煎煮用水；(2)将步骤1中的中药组方加入煎煮用水中浸泡2小时，然后文火煮沸30min，倒出药液，再次加入煎煮用水文火煮沸30min，倒出药液，第三次加入煎煮用水文火煮沸30min，倒出药液，将三次药液混合均匀、过滤形成元汤；(3)将步骤2中的元汤中加入蜂胶、甲基纤维素和蔗糖溶液，混合均匀后文火熬制成粘稠膏体。采用水洗后的水过滤作为煎煮用水以及三次煎煮工艺可有效避免药物中有效成份的流失。慢性咽炎患者可直接口服上述粘稠膏体，也可用开水冲服，每次10ml，每日三次。
优选的，可加热所述粘稠膏体直至去除其中所有水分，经冷却定型形成含片。所述含片经包装后便于随身携带，患者便于按时服用或咽部不适时服用。
优选的，所述中药组方浸泡前可进行适度破碎加工。中药组方破碎后更有利于药物中有效成分的析出，提高中药组方的利用率。
优选的，每次煎煮时加入煎煮用水的重量份数为中药组方的3-5倍。煎煮过程中可酌情加水，避免无水干煮，以水量可覆盖其中的中药组方为准。
优选的，所述蜂胶为6-12份。加入蜂胶可有效提升消炎镇痛疗效，同时也有利于药物的粘合成型。
优选的，所述粘稠膏体和所述含片的蔗糖含量均不超过50％。控制蔗糖含量，防止过高糖分对人体的不良影响，保证甲基纤维素含量，提高药物在水中的溶解性，易于吸收。
优选的，所述煎煮用水和元汤的过滤均采用100-200目的滤网。控制滤网的目数，保证滤除杂质的同时能够保留其中的有效药物成分。
本发明的中药组方，重用厚朴、枳实为君药，行气散结；桔梗宣肺行气、香附疏肝理气、陈皮与茯苓健脾行气为臣药；半夏、苏子化痰降气为佐，甘草味甘缓和，又可调和诸药为使药。本发明的药物组合物以“气”为核心，有升有降，兼顾肺、肝、脾，使气机调畅，用于治疗慢性咽炎引起的喉中异物感、干咳不止，疗效甚佳，不易复发。
临床试验：
选择某医院耳鼻喉科门诊病人86人，主要症状为：咽痒、咽部异物感、干咳不止。随机分为两组每组43人，一组用本发明药物组合物治疗，另一组选择西药治疗。西药治疗方案为：口服复方甘草片4片tid，维生素C100mgtid，含化华素片prn，疗程7天。试验结果如下表：
评价标准 治愈 好转 无效 有效率 2个月内复发
本发明 15人 24人 4人 90.7％ 3人
西药治疗 9人 20人 14人 67.4％ 9人
其中：“治愈”是指咽部异物感消失；“好转”是指咽部异物感减轻，偶有干咳；“无效”是指症状不缓解。可见两组治疗方案的有效率有明显差异(t＜0.05)，本发明的药物组合物疗效显著、不易复发。
具体实施方式
实施例一
一种用于治疗慢性咽炎的药物组合物，其经由以下步骤制作而成：(1)取厚朴20份、枳实20份、香附6份、桔梗15份、陈皮15份、茯苓12份、半夏9份、苏子12份、甘草6份、沉香3份、柴胡12份、竹茹15份、薄荷12份，经混合、水洗、干燥后形成中药组方，水洗后的水经过滤后形成煎煮用水；(2)将步骤1中的中药组方加入煎煮用水中浸泡2小时，然后文火煮沸30min，倒出药液，再次加入煎煮用水文火煮沸30min，倒出药液，第三次加入煎煮用水文火煮沸30min，倒出药液，将三次药液混合均匀、过滤形成元汤；(3)将步骤2中的元汤中加入蜂胶6份、甲基纤维素和蔗糖溶液，混合均匀后文火熬制成粘稠膏体。每次煎煮时加入煎煮用水的重量份数为中药组方的3倍。
实施例二
一种用于治疗慢性咽炎的药物组合物，其经由以下步骤制作而成：(1)取厚朴20份、枳实20份、香附6份、桔梗15份、陈皮15份、茯苓12份、半夏9份、苏子12份、甘草6份、沉香3份、柴胡12份、竹茹15份、薄荷12份，经混合、水洗、干燥后形成中药组方，水洗后的水经过滤后形成煎煮用水；(2)将步骤1中的中药组方加入煎煮用水中浸泡2小时，然后文火煮沸30min，倒出药液，再次加入煎煮用水文火煮沸30min，倒出药液，第三次加入煎煮用水文火煮沸30min，倒出药液，将三次药液混合均匀、过滤形成元汤；(3)将步骤2中的元汤中加入蜂胶10份、甲基纤维素和蔗糖溶液，混合均匀后文火熬制成粘稠膏体。每次煎煮时加入煎煮用水的重量份数为中药组方的4倍。
实施例三
一种用于治疗慢性咽炎的药物组合物，其经由以下步骤制作而成：(1)取厚朴20份、枳实20份、香附6份、桔梗15份、陈皮15份、茯苓12份、半夏9份、苏子12份、甘草6份、沉香3份、柴胡12份、竹茹15份、薄荷12份，经混合、水洗、干燥后形成中药组方，水洗后的水经过滤后形成煎煮用水；(2)将步骤1中的中药组方加入煎煮用水中浸泡2小时，然后文火煮沸30min，倒出药液，再次加入煎煮用水文火煮沸30min，倒出药液，第三次加入煎煮用水文火煮沸30min，倒出药液，将三次药液混合均匀、过滤形成元汤；(3)将步骤2中的元汤中加入蜂胶12份、甲基纤维素和蔗糖溶液，混合均匀后文火熬制成粘稠膏体。每次煎煮时加入煎煮用水的重量份数为中药组方的5倍。
实施例四
一种用于治疗慢性咽炎的药物组合物，其经由以下步骤制作而成：(1)取厚朴20份、枳实20份、香附6份、桔梗15份、陈皮15份、茯苓12份、半夏9份、苏子12份、甘草6份、沉香3份、柴胡12份、竹茹15份、薄荷12份，经混合、水洗、干燥后形成中药组方，水洗后的水经过滤后形成煎煮用水；(2)将步骤1中的中药组方加入煎煮用水中浸泡2小时，然后文火煮沸30min，倒出药液，再次加入煎煮用水文火煮沸30min，倒出药液，第三次加入煎煮用水文火煮沸30min，倒出药液，将三次药液混合均匀、过滤形成元汤；(3)将步骤2中的元汤中加入蜂胶6份、甲基纤维素和蔗糖溶液，混合均匀后文火熬制成粘稠膏体。每次煎煮时加入煎煮用水的重量份数为中药组方的3倍。加热所述粘稠膏体直至去除其中所有水分，经冷却定型形成含片。

Claims (7)

1.一种用于治疗慢性咽炎的药物组合物，其特征在于，其经由以下步骤制作而成：(1)取厚朴20份、枳实20份、香附6份、桔梗15份、陈皮15份、茯苓12份、半夏9份、苏子12份、甘草6份、沉香3份、柴胡12份、竹茹15份、薄荷12份，经混合、水洗、干燥后形成中药组方，水洗后的水经过滤后形成煎煮用水；(2)将步骤1中的中药组方加入煎煮用水中浸泡2小时，然后文火煮沸30min，倒出药液，再次加入煎煮用水文火煮沸30min，倒出药液，第三次加入煎煮用水文火煮沸30min，倒出药液，将三次药液混合均匀、过滤形成元汤；(3)将步骤2中的元汤中加入蜂胶、甲基纤维素和蔗糖溶液，混合均匀后文火熬制成粘稠膏体。
2.如权利要求1所述的用于治疗慢性咽炎的药物组合物，其特征在于：加热所述粘稠膏体直至去除其中所有水分，经冷却定型形成含片。
3.如权利要求1或2所述的用于治疗慢性咽炎的药物组合物，其特征在于：所述中药组方浸泡前可进行适度破碎加工。
4.如权利要求1或2所述的用于治疗慢性咽炎的药物组合物，其特征在于：每次煎煮时加入煎煮用水的重量份数为中药组方的3-5倍。
5.如权利要求1或2所述的用于治疗慢性咽炎的药物组合物，其特征在于：所述蜂胶为6-12份。
6.如权利要求1或2所述的用于治疗慢性咽炎的药物组合物，其特征在于：所述粘稠膏体和所述含片的蔗糖含量均不超过50％。
7.如权利要求1或2所述的用于治疗慢性咽炎的药物组合物，其特征在于：所述煎煮用水和元汤的过滤均采用100-200目的滤网。
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CN103721197A (zh) * 2014-01-21 2014-04-16 魏兴禹 一种治疗慢性咽炎的中药
CN104324174A (zh) * 2014-10-22 2015-02-04 四川金堂海纳生物医药技术研究所 一种治疗慢性咽炎的汤剂药物及其制备方法

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