CN105616357A - Resveratrol dry suspension and preparation method thereof - Google Patents
Resveratrol dry suspension and preparation method thereof Download PDFInfo
- Publication number
- CN105616357A CN105616357A CN201610006889.3A CN201610006889A CN105616357A CN 105616357 A CN105616357 A CN 105616357A CN 201610006889 A CN201610006889 A CN 201610006889A CN 105616357 A CN105616357 A CN 105616357A
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- China
- Prior art keywords
- resveratrol
- dry suspension
- preparation
- dry
- mixture
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
Abstract
The invention discloses a resveratrol dry suspension and a preparation method thereof and belongs to the field of pharmaceutic preparations. The resveratrol dry suspension consists of a suspending aid, ethanol, corrigent and an auxiliary agent. The preparation method has the characteristics of simple preparation method, high sedimentation volume ratio, good in medicine content uniformity and the like, and is easily accepted by patients.
Description
Technical field
The invention belongs to field of pharmaceutical preparations, be specifically related to a kind of resveratrol dry suspension and preparation method thereof.
Background technology
Resveratrol is a kind of phenols phytoalexin being found in Pericarpium Vitis viniferae and other plant, because resveratrol has anticancer, antioxidation, antiinflammatory, antibacterial effect and likes liking to people, plant origin mention because Frenchman often drinks in higher fatty acid thing containing resveratrol, so in other western countries at the bottom of French Incidence of CHD, resveratrol can be learnt from this information because effectively suppressing high-fat preventive and therapeutic effect. Existing Countries and area develop resveratrol using resveratrol and goods thereof as dietary supplement.
Resveratrol is insoluble in water, it is impossible to use after water-soluble, affects the absorption after it uses and convenience, brings restriction to its application.
Summary of the invention
An object of the present invention is to provide a kind of resveratrol dry suspension.
For achieving the above object, the technical scheme is that and be achieved in that:
A kind of resveratrol dry suspension, is made up of resveratrol 1-30% and adjuvant 70-99% part.
Further, resveratrol dry suspension described above, it is characterised in that described adjuvant is made up of suspending agent 1-5%, correctives 0-10%, filler 55-98%, solvent 2-30%.
Further, resveratrol dry suspension described above, it is characterized in that, described suspending agent is one or more in carbomer, gummi arabicum pulveratum, tragacanth, sodium carboxymethyl cellulose, hydroxy propyl cellulose, sodium alginate, microcrystalline Cellulose, it is preferred to sodium carboxymethyl cellulose.
Further, resveratrol dry suspension described above, it is characterized in that, described correctives is one or more compositions in sucralose, aspartame, sucrose, strawberry essence, trisodium citrate, it is preferable that the mixture of sucralose and strawberry essence.
Further, resveratrol dry suspension described above, it is characterised in that described solvent is one or more mixture in ethanol or glycerol, it is preferable that ethanol.
Further, resveratrol dry suspension described above, it is characterized in that, described filler is one or more mixture in lactose, mannitol, starch, xylitol, maltose alcohol, starch milk saccharide complex, sorbitol, it is preferable that the mixture of starch milk saccharide complex and mannitol.
The preparation method that it is a further object of the present invention to provide a kind of resveratrol dry suspension. In order to realize this purpose, the present invention is achieved by the following technical solutions:
Weigh the resveratrol of recipe quantity, add the solvent of recipe quantity, stirring, make resveratrol dissolve completely, obtain settled solution; Successively suspensoid, correctives, filler is added in solution, stirring, make soft material; By made soft material granulation, crossing 20 mesh sieves, 60 degrees Celsius dry, 20 mesh sieve granulate and get final product.
Beneficial effect of the present invention
The invention provides a kind of resveratrol dry suspension and preparation method thereof, solve resveratrol and be insoluble in water, it is impossible to by the water-soluble rear defect used, product sedimentation volume ratio is high, medicament contg homogeneity is good. Preparation method provided by the invention is simple, it is easy to accomplish.
Detailed description of the invention
Embodiment 1: resveratrol dry suspension and preparation method thereof
One, prescription: resveratrol 1g, sodium carboxymethyl cellulose 5g, ethanol 2g, starch milk saccharide complex 50g, mannitol 44g.
Two, preparation method: weigh the resveratrol of recipe quantity, adds the solvent of recipe quantity, stirring, makes resveratrol dissolve completely, obtains settled solution; Successively suspensoid, correctives, filler is added in solution, stirring, make soft material; By made soft material granulation, crossing 20 mesh sieves, 60 degrees Celsius dry, 20 mesh sieve granulate and get final product.
Embodiment 2: resveratrol dry suspension and preparation method thereof
One, prescription: resveratrol 30g, sodium carboxymethyl cellulose 1g, ethanol 30g, sucralose 9g, strawberry essence 1g, starch milk saccharide complex 35g, mannitol 24g.
Two, preparation method: weigh the resveratrol of recipe quantity, adds the solvent of recipe quantity, stirring, makes resveratrol dissolve completely, obtains settled solution; Successively suspensoid, correctives, filler is added in solution, stirring, make soft material; By made soft material granulation, crossing 20 mesh sieves, 60 degrees Celsius dry, 20 mesh sieve granulate and get final product.
Embodiment 3: resveratrol dry suspension and preparation method thereof
One, prescription: resveratrol 15g, sodium carboxymethyl cellulose 3g, ethanol 20g, sucralose 4.9g, strawberry essence 0.1g, starch milk saccharide complex 60g, mannitol 17g.
Two, preparation method: weigh the resveratrol of recipe quantity, adds the solvent of recipe quantity, stirring, makes resveratrol dissolve completely, obtains settled solution; Successively suspensoid, correctives, filler is added in solution, stirring, make soft material; By made soft material granulation, crossing 20 mesh sieves, 60 degrees Celsius dry, 20 mesh sieve granulate and get final product.
Test example: be the character of resveratrol dry suspension product, mouthfeel and sedimentation volume ratio test below
Experimental agents: the resveratrol dry suspension of embodiment 1��3 preparation.
Experimental technique: character by observing, nasil method, homogeneity and sedimentation volume ratio carry out according to " Chinese Pharmacopoeia " version two in 2010.
Experimental result: see table 1 below:
Table 1 resveratrol dry suspension character and sedimentation volume ratio result
| Laboratory sample | Face shaping | Mouthfeel | Homogeneity | Sedimentation volume ratio |
| Embodiment 1 | White or faint yellow granule | Sweet, mouthfeel is good | Qualified | 0.91 |
| Embodiment 2 | White or faint yellow granule | Sweet, mouthfeel is good | Qualified | 0.95 |
| Embodiment 3 | White or faint yellow granule | Sweet, mouthfeel is good | Qualified | 0.93 |
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.
Claims (7)
1. a resveratrol dry suspension, is made up of resveratrol 1-30% and adjuvant 70-99% part.
2. resveratrol dry suspension according to claim 1, it is characterised in that described adjuvant is made up of suspending agent 1-5%, correctives 0-10%, filler 55-98%, solvent 2-30%.
3. resveratrol dry suspension according to claim 1, it is characterized in that, described suspending agent is one or more in carbomer, gummi arabicum pulveratum, tragacanth, sodium carboxymethyl cellulose, hydroxy propyl cellulose, sodium alginate, microcrystalline Cellulose, it is preferred to sodium carboxymethyl cellulose.
4. resveratrol dry suspension according to claim 1, it is characterized in that, described correctives is one or more compositions in sucralose, aspartame, sucrose, strawberry essence, trisodium citrate, it is preferable that the mixture of sucralose and strawberry essence.
5. resveratrol dry suspension according to claim 1, it is characterised in that described solvent is one or more mixture in ethanol or glycerol, it is preferable that ethanol.
6. resveratrol dry suspension according to claim 1, it is characterized in that, described filler is one or more mixture in lactose, mannitol, starch, xylitol, maltose alcohol, starch milk saccharide complex, sorbitol, it is preferable that the mixture of starch milk saccharide complex and mannitol.
7. the preparation method of a resveratrol dry suspension, it is characterised in that weigh the resveratrol of recipe quantity, adds the solvent of recipe quantity, stirring, makes resveratrol dissolve completely, obtains settled solution; Successively suspensoid, correctives, filler is added in solution, stirring, make soft material; By made soft material granulation, crossing 20 mesh sieves, 60 degrees Celsius dry, 20 mesh sieve granulate and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610006889.3A CN105616357A (en) | 2016-01-07 | 2016-01-07 | Resveratrol dry suspension and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610006889.3A CN105616357A (en) | 2016-01-07 | 2016-01-07 | Resveratrol dry suspension and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105616357A true CN105616357A (en) | 2016-06-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201610006889.3A Pending CN105616357A (en) | 2016-01-07 | 2016-01-07 | Resveratrol dry suspension and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1935120A (en) * | 2005-08-04 | 2007-03-28 | 昆明杉榆生物技术有限公司 | Effervescent dry-mixed suspension agent |
| CN102307568A (en) * | 2009-02-04 | 2012-01-04 | 帝斯曼知识产权资产管理有限公司 | Resvertrol compositions |
| RU2557942C1 (en) * | 2014-03-19 | 2015-07-27 | Александр Александрович Кролевец | Method for producing supramolecular nanocapsules of resveratrol in xanthan gum |
-
2016
- 2016-01-07 CN CN201610006889.3A patent/CN105616357A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1935120A (en) * | 2005-08-04 | 2007-03-28 | 昆明杉榆生物技术有限公司 | Effervescent dry-mixed suspension agent |
| CN102307568A (en) * | 2009-02-04 | 2012-01-04 | 帝斯曼知识产权资产管理有限公司 | Resvertrol compositions |
| RU2557942C1 (en) * | 2014-03-19 | 2015-07-27 | Александр Александрович Кролевец | Method for producing supramolecular nanocapsules of resveratrol in xanthan gum |
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Application publication date: 20160601 |