CN105596981A - 用于治疗猝死型冠心病的药物 - Google Patents

用于治疗猝死型冠心病的药物 Download PDF

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CN105596981A
CN105596981A CN201511021659.6A CN201511021659A CN105596981A CN 105596981 A CN105596981 A CN 105596981A CN 201511021659 A CN201511021659 A CN 201511021659A CN 105596981 A CN105596981 A CN 105596981A
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杨桂珍
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Abstract

本发明公开了一种用于治疗猝死型冠心病的药物，主要由下述重量份配比的原料制成：黄芪12-18份，香橼皮5-7份，川芎8-12份，当归8-10份，白芍8-12份，红花8-12份，广郁金8-12份，白术8-12份，茯苓8-12份，丹参8-10份，五味子8-10份，苍术8-10份，川朴5-7份，栝楼5-7份，菖蒲5-7份。本发明用于治疗猝死型冠心病的药物，选取15种天然中药科学配伍，配方简单，各原料药协同作用起到理气活血、通络止痛的效果，见效快，标本兼治，无毒副作用，而且其制备方法简单、服用方便，成本低。有效率达到93％以上。

Description

用于治疗猝死型冠心病的药物
技术领域
本发明涉及中药，具体是一种用于治疗猝死型冠心病的药物。
背景技术
冠心病是中老年人常见的一种心血管疾病，是由于冠状动脉功能性改变或器质性病变引起的冠脉血流和心肌需求之间不平衡而导致的心肌损害。本病的基本病变是供应心肌营养物质的血管——冠状动脉发生了粥样硬化，故其全称为冠状动脉粥样硬化性心脏病，简称为冠心病。主要表现为心绞痛、心律失常、心力衰竭，可能猝死。心电图、心肌酶测定、放射性核素检查和冠状动脉造影能进一步明确诊断。控制血压、血脂、体重和戒烟能有效防止冠心病的发生和发展。
冠心病的危险因素包括可改变的危险因素和不可改变的危险因素。了解并干预危险因素有助于冠心病的防治。可改变的危险因素有：高血压，血脂异常(总胆固醇过高或低密度脂蛋白胆固醇过高、甘油三酯过高、高密度脂蛋白胆固醇过低)、超重/肥胖、高血糖/糖尿病，不良生活方式包括吸烟、不合理膳食(高脂肪、高胆固醇、高热量等)、缺少体力活动、过量饮酒，以及社会心理因素。不可改变的危险因素有：性别、年龄、家族史。此外，与感染有关，如巨细胞病毒、肺炎衣原体、幽门螺杆菌等。冠心病的发作常常与季节变化、情绪激动、体力活动增加、饱食、大量吸烟和饮酒等有关。
现在多以西药和手术治疗为主，但是副作用较大，且容易复发，不能根治，对患者经济和生理造成一定的负担。而目前的一些中药的治疗效率也不甚理想，治疗周期长，且疗效不显著。
发明内容
本发明的目的是提供一种疗效好、疗程短、成本低、无毒副作用的用于治疗猝死型冠心病的药物。
实现本发明目的的技术方案是：
一种用于治疗猝死型冠心病的药物，主要由下述重量份配比的原料制成：
黄芪12-18份，香橼皮5-7份，川芎8-12份，当归8-10份，白芍8-12份，红花8-12份，广郁金8-12份，白术8-12份，茯苓8-12份，丹参8-10份，五味子8-10份，苍术8-10份，川朴5-7份，栝楼5-7份，菖蒲5-7份。
上述用于治疗猝死型冠心病的药物，各原料的最佳重量份配比为：
黄芪15份，香橼皮6份，川芎10份，当归9份，白芍10份，红花10份，广郁金10份，白术10份，茯苓10份，丹参9份，五味子9份，苍术9份，川朴6份，栝楼6份，菖蒲6份。
所述的原料药材在中药店及市场有售。
本发明药物的制备方法如下：按重量配比称取各原料药，加入混合置于容器中，再加原料量重量10-20倍的水煎煮3次，每次煎煮30-40min，合并煎煮液，过滤去渣，滤液浓缩至50-60℃下相对密度为1.20-1.30的浸膏，加入辅料，制成相应的剂型，即得。
本发明中，各原料药的药理、功效如下：
黄芪：有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。黄芪不仅能扩张冠状动脉，改善心肌供血，提高免疫功能，而且能够延缓细胞衰老的进程。
香橼皮：舒肝理气，宽中，化痰。用于肝胃气滞，胸胁胀痛，脘腹痞满，呕吐噫气，痰多咳嗽。
川芎：行气开郁，法风燥湿，活血止痛。治风冷头痛旋晕，胁痛腹疼，寒痹筋挛，经闭，难产，产后瘀阻块痛，痈疽疮疡。用于月经不调，经闭痛经，瘕腹痛，胸胁刺痛，跌扑肿痛，头痛，风湿痹痛。
当归：具有补血活血，调经止痛，润肠通便之功效。常用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，风湿痹痛，跌扑损伤，痈疽疮疡，肠燥便秘。
白芍：具有养血调经，敛阴止汗，柔肝止痛，平抑肝阳之功效。常用于血虚萎黄，月经不调，自汗，盗汗，胁痛，腹痛，四肢挛痛，头痛眩晕。
红花：具有活血通经，散瘀止痛之功效。用于经闭，痛经，恶露不行，症瘕痞块，胸痹心痛，瘀滞腹痛，胸胁刺痛，跌扑损伤，疮疡肿痛。
广郁金：活血止痛，行气解郁，清心凉血，利胆退黄。
白术：具有健脾益气，燥湿利水，止汗，安胎的功效，用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。
茯苓：利水渗湿，健脾，宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。
丹参：具有活血祛瘀，通经止痛，清心除烦，凉血消痈之功效。用于胸痹心痛，脘腹胁痛，瘕瘕积聚，热痹疼痛，心烦不眠，月经不调，痛经经闭，疮疡肿痛。
五味子：具有收敛固涩，益气生津，补肾宁心之功效。常用于久嗽虚喘，梦遗滑精，遗尿尿频，久泻不止，自汗盗汗，津伤口渴，内热消渴，心悸失眠。
苍术：燥湿健脾，祛风散寒，明目。用于湿阻中焦，脘腹胀满，泄泻，水肿，脚气痿蹙，风湿痹痛，风寒感冒，夜盲，眼目昏涩。
川朴：行气消积；燥湿除满；降逆平喘。主治：食积气滞；腹胀便秘；湿阻中焦，脘痞吐泻；痰壅气逆；胸满喘咳。
栝楼：清热涤痰，宽胸散结，润燥滑肠。用于肺热咳嗽，痰浊黄稠，胸痹心痛，结胸痞满，乳痈，肺痈，肠痈肿痛，大便秘结。
菖蒲：化痰，开窍，健脾，利湿。用于癫痫，惊悸健忘，神志不清，湿滞痞胀，泄泻痢疾，风湿疼痛，痈肿疥疮。
本发明用于治疗猝死型冠心病的药物，选取15种天然中药科学配伍，配方简单，各原料药协同作用起到理气活血、通络止痛的效果，见效快，标本兼治，无毒副作用，而且其制备方法简单、服用方便，成本低。
具体实施方式
下面结合实施例对本发明内容作进一步的说明，但不是对本发明的限定。
实施例1
一种用于治疗猝死型冠心病的药物，主要由下述重量份配比的原料制成：
黄芪12kg，香橼皮5kg，川芎8kg，当归8kg，白芍8kg，红花8kg，广郁金8kg，白术8kg，茯苓8kg，丹参8kg，五味子8kg，苍术8kg，川朴5kg，栝楼5kg，菖蒲5kg。
制备方法如下：按上述称取各原料药混合置于容器中，再加原料量重量10倍的水煎煮3次，每次煎煮30min，合并煎煮液，过滤去渣，滤液浓缩至50℃下相对密度为1.20的浸膏，加入辅料，制成片剂，每片0.1g。
实施例2
一种用于治疗猝死型冠心病的药物，主要由下述重量份配比的原料制成：
黄芪15kg，香橼皮6kg，川芎10kg，当归9kg，白芍10kg，红花10kg，广郁金10kg，白术10kg，茯苓10kg，丹参9kg，五味子9kg，苍术9kg，川朴6kg，栝楼6kg，菖蒲6kg。
制备方法如下：按上述称取各原料药混合置于容器中，再加原料量重量15倍的水煎煮3次，每次煎煮34min，合并煎煮液，过滤去渣，滤液浓缩至54℃下相对密度为1.20的浸膏，加入辅料，制成片剂，每片0.2g。
实施例3
一种用于治疗猝死型冠心病的药物，主要由下述重量份配比的原料制成：
黄芪18kg，香橼皮7kg，川芎12kg，当归10kg，白芍12kg，红花12kg，广郁金12kg，白术12kg，茯苓12kg，丹参10kg，五味子10kg，苍术10kg，川朴7kg，栝楼7kg，菖蒲7kg。
制备方法如下：按上述称取各原料药混合置于容器中，再加原料量重量18倍的水煎煮3次，每次煎煮37min，合并煎煮液，过滤去渣，滤液浓缩至58℃下相对密度为1.30的浸膏，加入辅料，制成丸剂，每粒0.4g。
实施例4
一种用于治疗猝死型冠心病的药物，主要由下述重量份配比的原料制成：
黄芪18kg，香橼皮7kg，川芎12kg，当归10kg，白芍12kg，红花12kg，广郁金12kg，白术12kg，茯苓12kg，丹参10kg，五味子10kg，苍术10kg，川朴7kg，栝楼7kg，菖蒲7kg。
制备方法如下：按上述称取各原料药混合置于容器中，再加原料量重量20倍的水煎煮3次，每次煎煮40min，合并煎煮液，过滤去渣，滤液浓缩至60℃下相对密度为1.30的浸膏，加入辅料，制成丸剂，每粒0.5g。
为了进一步证明本发明中药的临床疗效，选择收治患者中的100例，对本发明药物的疗效进行临床观察。年龄50-70岁，随机分为4组，每组为25例，分别为实验组1-4组。
实验组1-4组分别服用实施例1-4的药物，每日2次，每次内服5片/粒，12天为一个疗程，连续服用1-2个疗程。其中显效91例，有效93例，治愈89例，无效7例，治愈率89％，有效率93％。

Claims (3)

1.一种用于治疗猝死型冠心病的药物，其特征是：主要由下述重量份配比的原料制成：
黄芪12-18份，香橼皮5-7份，川芎8-12份，当归8-10份，白芍8-12份，红花8-12份，广郁金8-12份，白术8-12份，茯苓8-12份，丹参8-10份，五味子8-10份，苍术8-10份，川朴5-7份，栝楼5-7份，菖蒲5-7份。
2.根据权利要求1所述的用于治疗猝死型冠心病的药物，其特征是：各原料的最佳重量份配比为：
黄芪15份，香橼皮6份，川芎10份，当归9份，白芍10份，红花10份，广郁金10份，白术10份，茯苓10份，丹参9份，五味子9份，苍术9份，川朴6份，栝楼6份，菖蒲6份。
3.根据权利要求1所述的用于治疗猝死型冠心病的药物，其特征是：
制备方法如下：按重量配比称取各原料药，加入混合置于容器中，再加原料量重量10-20倍的水煎煮3次，每次煎煮30-40min，合并煎煮液，过滤去渣，滤液浓缩至50-60℃下相对密度为1.20-1.30的浸膏，加入辅料，制成相应的剂型，即得。
CN201511021659.6A 2015-12-30 2015-12-30 用于治疗猝死型冠心病的药物 Pending CN105596981A (zh)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106075317A (zh) * 2016-08-22 2016-11-09 黄琴 用于治疗冠心病的药物
CN107096000A (zh) * 2017-05-26 2017-08-29 蒋田英 一种治疗冠心病的药物
CN109876113A (zh) * 2019-03-27 2019-06-14 苏凤哲 一种用于治疗颈动脉斑块的中药组合物及其制备方法和应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
周庆义: "逍遥散治疗冠心病", 《中国乡村医药杂志》 *
张波: "肺心痛胶囊调理肺脏功能治疗冠心病临床研究", 《现代中西医结合杂志》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106075317A (zh) * 2016-08-22 2016-11-09 黄琴 用于治疗冠心病的药物
CN107096000A (zh) * 2017-05-26 2017-08-29 蒋田英 一种治疗冠心病的药物
CN109876113A (zh) * 2019-03-27 2019-06-14 苏凤哲 一种用于治疗颈动脉斑块的中药组合物及其制备方法和应用

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