CN105596671A - Externally applied pharmaceutical composition for treating dermatophytosis - Google Patents

Externally applied pharmaceutical composition for treating dermatophytosis Download PDF

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Publication number
CN105596671A
CN105596671A CN201610020207.4A CN201610020207A CN105596671A CN 105596671 A CN105596671 A CN 105596671A CN 201610020207 A CN201610020207 A CN 201610020207A CN 105596671 A CN105596671 A CN 105596671A
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parts
pharmaceutical composition
externally applied
beriberi
treatment
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潘剑崎
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to an externally applied pharmaceutical composition for treating dermatophytosis. The externally applied pharmaceutical composition for treating dermatophytosis is prepared from 10 parts of Gecko, 5 parts of Chinese Chives, 12 parts of Caulis Lonicerae, 9 parts of Herba Andrographis, 5 parts of Medulla Junci, 2 parts of Herba Dianthi, 5 parts of Pine Nodular Branch, 10 parts of Caulis Sargentodoxae, 5 parts of Lentinula Edodes, 2 parts of Nelumbo Nucifera, 3 parts of Cortex Fraxini and 5 parts of Fistular Onion Stalk according to a certain weight proportion. Clinical test proves that the externally applied pharmaceutical composition is capable of safely and effectively treating dermatophytosis.

Description

A kind of externally-applied medicinal composition for the treatment of beriberi
Technical field
The present invention relates to a kind of Chinese medicine, especially relate to a kind of externally-applied medicinal composition for the treatment of beriberi.
Background technology
Beriberi is the extremely common infectious skin disease of one, is commonly called as again " ringworm of the foot ". In adult, the people of 70-80% has beriberi, just weight difference. Be everlasting and increase the weight of summer, alleviate winter, also has people not heal all the year round. Suffer from beriberi and itch easily occurs, occur stink etc., very inconvenience, therefore needs to treat in time in daily life.
Still lack at present the effective medicine of generally recognized as safe for beriberi at present.
The present Research of the related medicinal material of external application Chinese medicine of the present invention is as follows:
Gecko
What [source] was Gekkonidae animal without web gecko or other several geckoes is all.
[function cures mainly] dispels the wind, arresting convulsion, dissipating bind, removing toxic substances.
Leek
[source] Liliaceae allium leek AlliumtuberosumRottb.exSpreng., with all herbal medicine.
In [function cures mainly] temperature, promoting the circulation of qi, the loose stasis of blood, removing toxic substances.
Caulis lonicerae
[source] this product is the dry stem branch of caprifoliaceae plant honeysuckle LonicerajaponicaThunb..
[function cures mainly] is clearing heat and detoxicating, dispelling wind dredging collateral.
Herba Andrographitis
[source] is herb or the leaf of acanthaceous plant Herba Andrographitis.
[function cures mainly] is clearing heat and detoxicating, cool blood, detumescence.
Rush
[source] is stem marrow or the herb of rush family plant rush.
[function cures mainly] clearing away the heart-fire, diuresis.
Fringed pink
[source] is the wounded in the battle herb of pinkwort fringed pink or China pink.
[function cures mainly] clearing away heat and promoting diuresis, broken blood stimulates the menstrual flow.
Turpentine
[source] is the tubercle of the limb of pinaceae plant Chinese pine, masson pine or pinus yunnanensis.
[function cures mainly] dispels rheumatism, activating collaterals to relieve pain.
Sargentodoxa cuneata
[source] this product is plants of Lardizabalaceae sargentodoxa cuneata Sargentodoxacuneata(Oliv.) the dry rattan of Rehd.etWils..
[function cures mainly] is clearing heat and detoxicating, invigorates blood circulation, and dispels the wind.
Mushroom
[source] Mycophyta Basidiomycetes Agaricales Agaricaceae mushroom Lentinusedodes(Berk.) Sing, is used as medicine with fructification.
[function cures mainly] righting qi-restoratives; Spleen benefiting and stimulating the appetite; The promoting eruption of dispeling the wind.
Lotus flower
[source] is the bud of nymphaeaceae plant lotus.
[function cures mainly] scattered silt of invigorating blood circulation, the clearing damp wind that disappears.
The bark of ash
[source] is Oleaceae plants fraxinus rhynchophylla Hance, the bark of Fraxinus bungeana or Qinling Mountains Chinese ash.
[function cures mainly] heat-clearing and damp-drying drug, antiasthmatic-antitussive, improving eyesight.
Bulbus Allii Fistulosi
[source] this product is Liliaceae allium green onion AlliumfistulosumL., with bulb or all herbal medicine.
[function cures mainly] delivers, activate yang, and removing toxic substances.
Summary of the invention
The present invention aims to provide a kind of externally-applied medicinal composition for the treatment of beriberi, by selecting suitable medicinal material and proportioning thereof, reaches the object of safe and effective healing beriberi.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of externally-applied medicinal composition for the treatment of beriberi, it is characterized by, make paste by the raw material of following parts by weight: 10 parts of geckoes, 5 parts, leek, 12 parts of caulis loniceraes, 9 parts of Herba Andrographitis, 5 parts of rushes, 2 parts of fringed pinks, 5 parts of turpentines, 10 parts of sargentodoxa cuneata, 5 parts, mushroom, 2 parts, lotus flower, 3 parts of the barks of ash, 5 parts of Bulbus Allii Fistulosi.
Chinese medicine of the present invention is paste, after each raw material is cleaned up, makes according to a conventional method paste, spreads on affected part outward and smears and absorb and clean use.
Below in conjunction with clinical trial data declaration beneficial effect of the present invention:
1, physical data
Inventor in February, 2014-2015 are collected the out-patient of 113 routine beriberi, age 23-59 year, the course of disease 3 months-18 months altogether between year August. Be divided at random: treatment group 83 examples, blank group 30 examples. The data there was no significant differences such as two groups of ages, the state of an illness, have comparativity.
2, diagnostic criteria
Medically conventionally beriberi is divided to three types: erosive type, vesicle, scales of skin that peel off keratinization type beriberi.
1. erosive type: be apt to occur between the 3rd and the four, four and the 5th toe. From the beginning of moist between toe, dipping turns white, and after dry furfur, peels off scurf and be the rotten to the corn face of moistening, flush or with breach, odd itching, easily scabies secondary infection.
2. vesicle: be apt to occur in sufficient edge, vola portion. From the beginning of being the full phlysis of wall thickness, the be fused into bleb having, blister liquid is transparent, around without blush. Consciously very itch, after scratching often because scabies secondary infection causes erysipelas, angioleucitis etc.
3. scales of skin that peel off keratinization type: be apt to occur in heel, sufficient edge. Because fungal infection causes slightly thick, furfur of dry skin, cutin, easily chap. This type is without blister and suppuration, and the course of disease is slow, how not to heal throughout the year, and Most patients is transformed by erosive type, vesicle.
3, test method
3.1 treatment groups are used external-applied ointment of the present invention, and affected part is cleaned and dried, and get appropriate ointment and are evenly applied in affected part, and be massaged into ointment and absorb completely, with afterwash, every 8 hours are once, within 5 days, be 1 course for the treatment of, use continuously 2～3 courses for the treatment of, the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Clean affected part with clear water for 3.2 blank groups, every 8 hours once, within 5 days, is 1 course for the treatment of, continuous 2～3 courses for the treatment of.
4, criterion of therapeutical effect and treatment results
4.1 criterion of therapeutical effect
With reference to State Administration of Traditional Chinese Medicine " disease of tcm Standardization of diagnosis and curative effect "
Recovery from illness: clinical symptom disappearance after treatment, athlete's foot recovery from illness, half a year is without recurrence;
Take a turn for the better: clinical symptoms are obviously improved, and athlete's foot is progressively recovered;
Invalid: clinical partial symptoms disappears or without change, do not reach improvement standard person.
4.2 treatment statisticses are in table 1.
Table 1 liang group curative effect comparison
Group n Recovery from illness Take a turn for the better Invalid Total effective rate (%) Bad reaction example
Treatment group 83 27（32.5%） 41（49.4%） 15（18.0%） 82.0% 0
Blank group 30 0（0.0%） 2（6.6%） 28（93.4%） 6.6% 0
For proving that the present invention has good curative effect, enumerate model case as follows:
1, Song × ×, man, 26 years old, it is serious that patient tells its beriberi, and after motion in summer, pin is smelly particularly evident especially, once used multiple external application and endo-medicine treatment, but beriberi has no radical cure, after give external application Chinese medicine of the present invention treatment, smear after the course for the treatment of, above-mentioned beriberi obviously takes a turn for the better to some extent, continuous with recovering normal after two courses for the treatment of, inspection subsequently shows no abnormality seen, not recurrence so far.
2, open ×, man, 37 years old, main suit's beriberi was serious; smelly obviously foot often there will be vesicle bubble etc. and area constantly to expand, and the dry decortication of pin is with onychomycosis; go to subsequently local hospital to be diagnosed as beriberi by routine inspection, hospital adopts routine medication, the not substantive to some extent alleviation of symptom. After give external application Chinese medicine of the present invention treatment, smear after the course for the treatment of, beriberi phenomenon takes a turn for the better to some extent, continues to smear after two courses for the treatment of, state of an illness rehabilitation is complete, and so far without recurring.
3, gold ×, female, 32 years old, it is due to husband is infected that patient tells beriberi, there will be multiple bubbles on toe, follows scratchiness, the ointment of smearing Da Kening and so on does not have material alterations, goes to subsequently local hospital to be diagnosed as beriberi by routine inspection, and hospital adopts conventional therapy, symptom is not alleviated to some extent, after give external application Chinese medicine of the present invention treatment, smear after the course for the treatment of, above-mentioned beriberi obviously takes a turn for the better to some extent, continuous use recovers normal after smearing two courses for the treatment of, checks subsequently and shows no abnormality seen, so far not recurrence.
Visible, the present invention adopts the formula of science and suitable proportioning, and, removing toxic substances desinsection antipruritic taking removing heat to expel wind, eliminating stasis to subdue swelling, eliminating dampness, as treatment rule, adopts between each medicine and cooperatively interact, synergy, made external application Chinese medicine medicine can safe and effective treatment beriberi.
Detailed description of the invention
In order to understand better and to implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take: 10 grams of geckoes, 5 grams, leek, 12 grams of caulis loniceraes, 9 grams of Herba Andrographitis, 5 grams of rushes, 2 grams of fringed pinks, 5 grams of turpentines, 10 grams of sargentodoxa cuneata, 5 grams, mushroom, 2 grams, lotus flower, 3 grams of the barks of ash, 5 grams of Bulbus Allii Fistulosi, above-mentioned raw materials is cleaned up, put into lapping apparatus pulverization, make paste by sesame oil furnishing pasty state or other conventional methods, must meet normal 1 day paste consumption.
Usage and dosage: affected part is cleaned and dried, get appropriate ointment and be evenly applied in affected part, and be massaged into ointment and absorb completely, with afterwash, every 8 hours once, is used for the treatment of beriberi.

Claims (1)

1. treat the externally-applied medicinal composition of beriberi for one kind, it is characterized by, make paste by the raw material of following parts by weight: 10 parts of geckoes, 5 parts, leek, 12 parts of caulis loniceraes, 9 parts of Herba Andrographitis, 5 parts of rushes, 2 parts of fringed pinks, 5 parts of turpentines, 10 parts of sargentodoxa cuneata, 5 parts, mushroom, 2 parts, lotus flower, 3 parts of the barks of ash, 5 parts of Bulbus Allii Fistulosi.
CN201610020207.4A 2016-01-13 2016-01-13 Externally applied pharmaceutical composition for treating dermatophytosis Pending CN105596671A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102805832A (en) * 2012-08-28 2012-12-05 兰恒志 External medicament for treating dermatophytosis and preparation method thereof
CN102846803A (en) * 2012-09-06 2013-01-02 丁海望 External application drug for treating beriberi
CN103251676A (en) * 2013-05-28 2013-08-21 阎靖涛 External-application medicament for treating beriberi and pruritus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102805832A (en) * 2012-08-28 2012-12-05 兰恒志 External medicament for treating dermatophytosis and preparation method thereof
CN102846803A (en) * 2012-09-06 2013-01-02 丁海望 External application drug for treating beriberi
CN103251676A (en) * 2013-05-28 2013-08-21 阎靖涛 External-application medicament for treating beriberi and pruritus

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