CN105596494A - Traditional Chinese medicine composition for treating idiopathic pulmonary arterial hypertension and preparing method and application thereof - Google Patents

Traditional Chinese medicine composition for treating idiopathic pulmonary arterial hypertension and preparing method and application thereof Download PDF

Info

Publication number
CN105596494A
CN105596494A CN201610001498.2A CN201610001498A CN105596494A CN 105596494 A CN105596494 A CN 105596494A CN 201610001498 A CN201610001498 A CN 201610001498A CN 105596494 A CN105596494 A CN 105596494A
Authority
CN
China
Prior art keywords
parts
chinese medicine
medicine composition
idiopathic pulmonary
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610001498.2A
Other languages
Chinese (zh)
Inventor
郑威
于雪飞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harbin University of Commerce
Original Assignee
Harbin University of Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harbin University of Commerce filed Critical Harbin University of Commerce
Priority to CN201610001498.2A priority Critical patent/CN105596494A/en
Publication of CN105596494A publication Critical patent/CN105596494A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Insects & Arthropods (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a traditional Chinese medicine composition for treating idiopathic pulmonary arterial hypertension. The traditional Chinese medicine composition comprises, by weight, 2-3 parts of white muscardine silkworms, 5-10 parts of herba cistanche, 5-10 parts of radix angelicae pubescentis, 1-3 parts of lotus seed cores, 1-3 parts of dogbane leaves, 5-10 parts of lemon, 0.01-0.05 part of mint, 0.01-0.05 part of pig lung extract and 0.01-0.05 part of Chinese littleleaf box extract. All the raw materials are prepared, smashed, decocted and extracted, then ethyl alcohol is added to serve as a dissolution assistant, and a finished product is obtained. By means of the traditional Chinese medicine composition, pulmonary arterial hypertension can be reduced, pulmonary artery smooth muscle cell proliferation is reduced, blood-vessel-periphery inflammatory cells are obviously reduced, the lesion lung tissue structure and right ventricular hypertrophy can be improved, alveolar-space edema, bleeding and intrapulmonary arteriolar wall and smooth muscle hypertrophy can be relieved, pulmonary vascular resistance can be improved, idiopathic pulmonary arterial hypertension can be effectively treated, and the curative effect is remarkable.

Description

A kind of Chinese medicine composition that is used for the treatment of idiopathic pulmonary hypertension disease and its preparation method and application
Technical field
The present invention relates to field of medicaments, specifically a kind of Chinese medicine composition that is used for the treatment of idiopathic pulmonary hypertension disease and its preparation method and application.
Background technology
Idiopathic pulmonary hypertension (IPAH) refers to that agnogenic pulmonary vascular resistance increases, cause that persistent pulmonary hypertension power raises, cause evaluating pulmonary artery pressure under quiescent condition >=25mmHg, get rid of all Secondary cases factors that cause pulmonary hypertension, this disease etiology unknown, may there is medicine factor, virus infections and inherent cause are relevant, idiopathic pulmonary hypertension early symptom is not obvious, it is mainly the performance of pulmonary hypertension and right heart function exhaustion, the order of severity of the state of an illness is depended in concrete manifestation, common initial symptoms has: expiratory dyspnea, tired, pectoralgia, dizzy, oedema, faint, palpitaition, clinical manifestation is expiratory dyspnea, pectoralgia, faint, tired, spitting of blood, edema of lower extremity, can there is right heart failure, pulmonary infection, pulmonary embolism in idiopathic pulmonary hypertension, the complication such as die suddenly, faint, it is a kind of progressivity disease, treatment is mainly for aspects such as vessel retraction, inner film injury, thrombosis and heart failures, be intended to reduce pulmonary vascular resistance and pressure, improve heart function, increase cardiac output, improve symptom and prognosis, current therapeutic scheme adopts the Western medicine therapy such as oral retarding agent or injection antagonist mostly, exist side effect large, cost is high, the problem that state of an illness slow release effect is poor, and the words of employing surgical operation therapy, cost is large, the weakly patient of later stage that is unfavorable for falling ill, and after operating on, its 5 years survival rates are only 40%-50%, China is vast in territory, Chinese medicine medication is with a long history, treatment by Chinese herbs side effect is little, it is basic to control, be particular about reinvigoration, go out a Chinese medicine preparation and treat idiopathic pulmonary hypertension disease if can study compatibility, will alleviate greatly the financial burden of sufferer, reduce its medication side effect, improve cure rate.
Summary of the invention
The object of the present invention is to provide a kind ofly have no side effect, cure rate is high, drug cost the is low Chinese medicine composition that is used for the treatment of idiopathic pulmonary hypertension disease and its production and use, to solve the problem proposing in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
Be used for the treatment of a Chinese medicine composition for idiopathic pulmonary hypertension disease, formed by the raw material of following weight portion: larva of a silkworm with batrytis 2-3 part, saline cistanche 5-10 part, levisticum 5-10 part, embryo nelumbinis 1-3 part, Folium Apocyni Veneti 1-3 part, lemon 5-10 part, peppermint 0.01-0.05 part, pig lung extract 0.01-0.05 part, Chinese littleleaf box extract 0.01-0.05 part.
As the further scheme of the present invention: described in be used for the treatment of the Chinese medicine composition of idiopathic pulmonary hypertension disease, formed by the raw material of following weight portion: 2 parts of the larva of a silkworm with batrytis, 7 parts of saline cistanches, 7 parts of levisticums, 2 parts of embryo nelumbinises, 2 parts of Folium Apocyni Venetves, 7 parts, lemon, 0.03 part of peppermint, 0.03 part of pig lung extract, 0.03 part of Chinese littleleaf box extract.
As further scheme of the present invention: the active ingredient of described pig lung extract is one or more in phosphatid ylcholine, DPPC, phosphatidyl-ethanolamine, phosphatidylserine, phosphinositides and sphingomyelins.
As further scheme of the present invention: described in be used for the treatment of the preparation method of the Chinese medicine composition of idiopathic pulmonary hypertension disease, comprise the following steps:
1) press formula ratio and weigh the larva of a silkworm with batrytis, saline cistanche, levisticum, embryo nelumbinis, Folium Apocyni Veneti, after cleaning, pulverize and cross 80 eye mesh screens through pulverizer, under 50-70 DEG C of condition, dry, dry in the air for subsequent use to room temperature;
2) mixture of step 1 is put into material-compound tank, add purified water according to the solid-liquid ratio of 1:10, decoct 40-60min, filter, get decoction liquor for the first time, filter residue continues to decoct;
3) filter residue of step 2 is added to purified water according to the solid-liquid ratio of 1:5, decoct 30-40min, filter, get decoction liquor for the second time, filter residue continues to decoct;
4) filter residue of step 3 is added to purified water according to the solid-liquid ratio of 1:3, and add the lemon of the stripping and slicing of formula ratio, decoct 10-20min, get decoction liquor for the third time, and with decoction liquor for the first time, decoction liquor merges for the second time;
5) in the mixing decoction liquor merging, add peppermint, pig lung extract and the Chinese littleleaf box extract of formula ratio to obtain medicine stoste, and add ethanol as dissolution aids, stir, sterilizing packing obtains described Chinese medicine composition liquid.
As further scheme of the present invention: described Chinese medicine composition liquid is prepared into oral liquid or spray through conventional method.
As further scheme of the present invention: described in be used for the treatment of idiopathic pulmonary hypertension disease the application of Chinese medicine composition in preparation treatment idiopathic pulmonary hypertension medicine.
Pharmacological action of the present invention:
1. the larva of a silkworm with batrytis: originate as the larva of Bombycidae insect silkworm moth infects the ossified dry full worm of muscardine, have anticonvulsant action, syngignoscism, containing vitamin E 9.89%, can remove free radical, anti-lipid oxidation; Taste is salty, flat; Enter the heart, liver, spleen, lung four warps; " Bencao Tujing ": control apoplexy, acute throat obstruction, smashes sieve smalls, the filling of ginger nature juice tune.
2. saline cistanche: be a kind of parasitic plant that colonizes in desert trees sacsaoul root, taste is sweet; Salty; Warm in nature; Return kidney; Large intestine channel; Function cures mainly: kidney-replenishing; Benefiting essence-blood; Ease constipation road. Main decline of kidney-YANG; The impotence of asthenia of essence and blood; Seminal emission; Gonorrhoea; The frequent micturition heeltap; Pain in the back flaccidity of lower limbs; Tinnitus order flower; Menstruation is spread out the phase; Fertility; The dry constipation of intestines; Have anti-ageing, adjust endocrine, promote metabolism and strong effect, strengthen immunocompetence; Saline cistanche can make the activity of mouse red blood cell superoxide dismutase (SOD) obviously strengthen, and mouse cardiac muscle lipofuscin content is obviously reduced; Water-leach liquor, alcohol-water leachate and the alcohol leaching liquid of saline cistanche have hypotensive effect to anesthetized dog, cat, rabbit etc.; In saline cistanche, active ingredient phenylethanoid glycosides is improved microcirculation, and softening blood vessel, the increase heart, brain and the circulation of outer four limbs peripheral vessel, reach the protection blood cerebrovascular and neural effect.
3. levisticum: be the dry root of samphire Angelica pubescens AngelicapubescensMaxim.f.biserrataShanetYuan, taste is pungent, bitter, slightly warm in nature; Return kidney, urinary bladder channel; Dispel rheumatism, arthritis pain relieving; Cure mainly for wind-cold-dampness arthralgia, wash pain, few cloudy volt wind headache, chill is held wet headache under the arm.
4. embryo nelumbinis: dry spire and radicle in the mature seed of genus nymphaeaceae plant lotus, cold in nature, bitter, nontoxic; The effects such as having clears away heart-fire reduces phlegm and internal heat, puckery essence, hemostasis, cough-relieving, can treat heart failure, shock, impotence, vexed, thirsty, haematemesis, seminal emission, hot eyes, the illness such as swell and ache; There is blood sugar reducing function; There is promotion blood coagulation, make some enzyme activation, maintain nerve conductivity, calm neural, maintain the effect such as the retractility of muscle and the rhythm and pace of moving things of heartbeat; There is remarkable cardiotonic, can expand peripheral vascular, reduce blood pressure.
5. Folium Apocyni Veneti: Angiospermae, Dicotyledoneae, has step-down, cardiac stimulant, radiation resistance; Endogenous blood fat is raise and has reducing effect; Phagocytosis By The Peritoneal Macrophages In Mice is had to humidification; Cardiovascular system is had to hemangiectasis effect, there is diuresis, effect for reducing blood fat.
6. lemon: Rutaceae citrus plant lemon CitruslimoniaOsbeck, is used as medicine with root with fruit, really: sour, sweet, flat; Root: pungent, bitter, temperature; Really: preventing phlegm from forming and stopping coughing, the stomach invigorating of promoting the production of body fluid; For bronchitis, pertussis, poor appetite, Vitamin C deficiency disease, heatstroke polydipsia; Root: promoting qi circulation and relieving pain, relieving cough and asthma; For stomachache, hernia pain, orchitis, cough, bronchial astehma; Contain hesperidine (hesperdin), cupreol (β-sitosterol), clionasterol (γ-sitosterol) containing Canton lemon pericarp; Lemon pericarp is containing hesperidine (hesperidin), diosmin (diosmin), naringin (naringin), neohesperidin (neohesperidin), caffeic acid (caffeicacid); Seed is containing obakunone (obacunone), limonin (limonin).
7. peppermint: popular name, " lunar caustic grass ", is labiate, and taste is pungent, cool in nature; Enter lung, Liver Channel; Dispelling wind and heat from the body, the clear sharp head, relieve sore throat promoting eruption, soothing the liver promoting the circulation of qi; Cure mainly affection of exogenous wind-heat, headache, abscess of throat, eats stagnant inflatable, aphtha, toothache, sore scabies, urticaria, warm disease from the beginning of, rubella itch, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.
8. pig lung extract: pig lung taste is sweet, property is flat, returns lung channel, tonify the lung to relieve cough, hemostasis, for cough due to deficiency of the lung, spitting of blood; Its active ingredient phosphatid ylcholine can turn to superfine particle by the cholesterol in blood and aliphatic acid, from blood vessel, discharges, and the HDL that raise, makes blood vessel recover elasticity, and blood flow is unimpeded, has effect promoting blood circulation and removing blood stasis, wind-expelling pain-stopping.
9. Chinese littleleaf box extract: promoting circulation of blood, wind-expelling pain-stopping, removing toxic substances.
Compared with prior art, the invention has the beneficial effects as follows: compared with Western medicine preparation, Chinese medicine preparation has the feature of " many target spots, manifold effect ", the selected medicinal material compatibility of the present invention is suitable, meet traditional Chinese medicine and pharmacy and modern medicine theory, Chinese medicine composition of the present invention can eliminate atherosclerotic plaque, dredging vascellum, accelerate blood circulation, can repair and hemangiectasis, cleaning thrombus, reaches antihypertensive effect fast, hypotensive effect relaxes, and stabilizing blood pressure effect is better; That the present invention has is promoting blood circulation and removing blood stasis, the effect of cardiac stimulant step-down, wind-expelling pain-stopping, adjusting immunity, safe and reliable, without any side effects, short treating period, and instant effect, with low cost, and can reach the object for the treatment of both principal and secondary aspect of disease, wide popularization and application on clinic.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the technical scheme of this patent is described in more detail.
Embodiment 1
Be used for the treatment of a Chinese medicine composition for idiopathic pulmonary hypertension disease, formed by the raw material of following weight portion: 2 parts of the larva of a silkworm with batrytis, 5 parts of saline cistanches, 5 parts of levisticums, 1 part of embryo nelumbinis, 1 part of Folium Apocyni Veneti, 5 parts, lemon, 0.01 part of peppermint, 0.01 part of pig lung extract, 0.01 part of Chinese littleleaf box extract.
Embodiment 2
Be used for the treatment of a Chinese medicine composition for idiopathic pulmonary hypertension disease, formed by the raw material of following weight portion: 3 parts of the larva of a silkworm with batrytis, 10 parts of saline cistanches, 10 parts of levisticums, 3 parts of embryo nelumbinises, 3 parts of Folium Apocyni Venetves, 10 parts, lemon, 0.05 part of peppermint, 0.05 part of pig lung extract, 0.05 part of Chinese littleleaf box extract.
Embodiment 3
Be used for the treatment of a Chinese medicine composition for idiopathic pulmonary hypertension disease, formed by the raw material of following weight portion: 2 parts of the larva of a silkworm with batrytis, 7 parts of saline cistanches, 7 parts of levisticums, 2 parts of embryo nelumbinises, 2 parts of Folium Apocyni Venetves, 7 parts, lemon, 0.03 part of peppermint, 0.03 part of pig lung extract, 0.03 part of Chinese littleleaf box extract.
Embodiment 4
Be used for the treatment of a Chinese medicine composition for idiopathic pulmonary hypertension disease, formed by the raw material of following weight portion: 2 parts of the larva of a silkworm with batrytis, 6 parts of saline cistanches, 6 parts of levisticums, 1 part of embryo nelumbinis, 1 part of Folium Apocyni Veneti, 6 parts, lemon, 0.02 part of peppermint, 0.02 part of pig lung extract, 0.02 part of Chinese littleleaf box extract.
Embodiment 5
Be used for the treatment of a Chinese medicine composition for idiopathic pulmonary hypertension disease, formed by the raw material of following weight portion: 3 parts of the larva of a silkworm with batrytis, 8 parts of saline cistanches, 8 parts of levisticums, 3 parts of embryo nelumbinises, 3 parts of Folium Apocyni Venetves, 8 parts, lemon, 0.04 part of peppermint, 0.04 part of pig lung extract, 0.04 part of Chinese littleleaf box extract.
Described in embodiment 1-5, the active ingredient of pig lung extract is one or more in phosphatid ylcholine, DPPC, phosphatidyl-ethanolamine, phosphatidylserine, phosphinositides and sphingomyelins; The preparation method who is used for the treatment of the Chinese medicine composition of idiopathic pulmonary hypertension disease described in embodiment 1-5, comprises the following steps:
1) press formula ratio and weigh the larva of a silkworm with batrytis, saline cistanche, levisticum, embryo nelumbinis, Folium Apocyni Veneti, after cleaning, pulverize and cross 80 eye mesh screens through pulverizer, under 50-70 DEG C of condition, dry, dry in the air for subsequent use to room temperature;
2) mixture of step 1 is put into material-compound tank, add purified water according to the solid-liquid ratio of 1:10, decoct 40-60min, filter, get decoction liquor for the first time, filter residue continues to decoct;
3) filter residue of step 2 is added to purified water according to the solid-liquid ratio of 1:5, decoct 30-40min, filter, get decoction liquor for the second time, filter residue continues to decoct;
4) filter residue of step 3 is added to purified water according to the solid-liquid ratio of 1:3, and add the lemon of the stripping and slicing of formula ratio, decoct 10-20min, get decoction liquor for the third time, and with decoction liquor for the first time, decoction liquor merges for the second time;
5) in the mixing decoction liquor merging, add peppermint, pig lung extract and the Chinese littleleaf box extract of formula ratio to obtain medicine stoste, and add ethanol as dissolution aids, stir, sterilizing packing obtains described Chinese medicine composition liquid.
Described Chinese medicine composition liquid is prepared into oral liquid or spray through conventional method, described in be used for the treatment of idiopathic pulmonary hypertension disease the application of Chinese medicine composition in preparation treatment idiopathic pulmonary hypertension medicine.
The result for the treatment of of the present invention to monocrotaline pulmonary hypertension (MCT-PAH) modeling rat:
Experiment in MCT-PAH rat body: 60 of male Sprague-Dawley rats (National Institute for Food and Drugs Control) are divided into 6 groups every group each 10, each group adaptability is divided into groups after feeding, except blank group, each treated animal all copies pulmonary hypertension model and obtains pulmonary hypertension (MCT-PAH) and make film rat according to the subcutaneous monocrotaline (MCT, 55mg/kg) that gives of single; After 3 weeks, respectively organize gastric infusion, blank group and model control group give equivalent physiological saline, and other groups give the medicine stoste of the embodiment of the present invention 3 formula preparations, administration every day 1 time, administration 20 days.
1. blank group: gavage gives same volume physiological saline;
2. model control group: gavage gives same volume physiological saline;
3. positive drug group: gavage gives the hydrolazine medicine of 5mg/kg without solution;
4. composition low dose group: gavage gives 1.0mL/kg medicine stoste;
5. dosage group in composition: gavage gives 2.0mL/kg medicine stoste;
6. composition high dose group: gavage gives 5.0mL/kg medicine stoste;
Test group animal is anaesthetized after 2 hours in last administration, and measure pulmonary arterial pressure, result is as following table:
Wherein, with the comparison of blank group,##P < 0.01; With model group comparison*P＜0.05，**P < 0.01, above experiment shows that the present invention can significantly reduce the mean pulmonary arterial pressure of experimental rat, pulmonary hypertension (MCT-PAH) is made to film rat good result for the treatment of; The situation of pathological section shows: model group animal pulmonary artery blood tube wall and pneumonocyte wall obviously thicken, and lung tissue structure is unintelligible, and blood vessel has a large amount of cell infiltration around; Composition medicine group can reduce pulmonary arterial smooth muscle cell hyperplasia, sexual cell obviously reduces periangiitis, lung tissue structure is comparatively clear, and effect is better than positive drug group, illustrates that the Pulmonary Hypertension that Chinese medicine composition of the present invention causes monocrotaline has good improvement effect.
Clinical testing statistics of the present invention is as follows:
1. subjects: certain institute of traditional Chinese medicine accepts out-patient's 200 examples for medical treatment, M-F is 1:1,55 years old mean age, average course of disease 16 months.
2. usage and dosage: select medicine prepared by the formula of the embodiment of the present invention 3 as trial drug, each 10ml, three times on the one 10 days is a course for the treatment of, test period is 3 courses for the treatment of.
3. curative effect determinate standard
(1) cure: each clinical symptom disappearance, expiratory dyspnea, pectoralgia, the symptom such as dizzy disappear completely, and physique is restored, and indices inspection is all normal;
(2) effective: each clinical symptoms obviously alleviate, expiratory dyspnea, pectoralgia, the symptom such as dizzy disappear substantially, and indices progressively recovers;
(3) invalid: each clinical symptoms are without any improvement.
4. treatment results statistics
Learn from upper table:
Using 1 of the present invention total effective rate course for the treatment of is 88%, inefficiency 12%, recurrence rate 5%;
Using 2 of the present invention total effective rate course for the treatment of is 93%, and inefficiency is 7%; Recurrence rate 3%;
Using 3 of the present invention total effective rate course for the treatment of is 96%, and inefficiency is 4%, recurrence rate 1%.
Can find that by above data treatment total effective rate the present invention has significant curative effect for the treatment of idiopathic pulmonary hypertension, can effectively improve the cure rate for the treatment of, reduce recurrence rate, be worth promoting clinically.
Model case is given an example:
1. Cao, man, 48 years old, HPVD, clinical manifestation,, easily there is blood supply insufficiency type stupor in expiratory dyspnea, poor appetite, dizziness, uses after 3 courses for the treatment of of the present invention, conditions of patients is almost recovered, not recurrence in 18 months phases of tracking.
2. Cai, female, 26 years old, medical weak after appearance activity before 1 year, feel suffocated, increase the weight of gradually, within nearly two months, there is heating, cough, spitting of blood, body temperature is at 37.5-38.5 DEG C, outer court gives anti-infective therapy, the state of an illness is without improvement, without arthralgia, canker sore, alopecia; BP110/70mmHg, R15 beat/min, two pulmonary respiration sounds are clear, do not hear and dry moist rale two lung audible vascular noises; 82 beats/min of hearts rate, heart rate is neat, and each valve area is not heard and noise; Lung perfusion/ventilation imaging shows, the multiple blood perfusion of two lungs is impaired, involve right lung all lung sections except part back segment, and left lung nextpage, pulmonary parenchyma is normal, right auxocardia, use after 3 courses for the treatment of of the present invention, symptom is eased, and decrement is consolidated and taken 2 all after dates, conditions of patients is almost recovered, not recurrence in 18 months phases of tracking.
The present invention can reduce pulmonary hypertension, reduce pulmonary arterial smooth muscle cell hyperplasia, periangiitis sexual cell is obviously reduced, can improve diseased lung tissue structure, can improve right ventricle plumpness, alleviate alveolar space oedema, hemorrhage, pulmonary artery and smooth muscle and thicken, improve pulmonary vascular resistance, can effectively treat idiopathic pulmonary hypertension, evident in efficacy.
Above the preferred embodiments of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment, in the ken that one skilled in the relevant art possesses, can also under the prerequisite that does not depart from this patent aim, makes various variations.

Claims (6)

1. a Chinese medicine composition that is used for the treatment of idiopathic pulmonary hypertension disease, is characterized in that: the raw material by following weight portion forms: larva of a silkworm with batrytis 2-3 part, saline cistanche 5-10 part, levisticum 5-10 part, embryo nelumbinis 1-3 part, Folium Apocyni Veneti 1-3 part, lemon 5-10 part, peppermint 0.01-0.05 part, pig lung extract 0.01-0.05 part, Chinese littleleaf box extract 0.01-0.05 part.
2. a kind of Chinese medicine composition that is used for the treatment of idiopathic pulmonary hypertension disease according to claim 1, it is characterized in that, formed by the raw material of following weight portion: 2 parts of the larva of a silkworm with batrytis, 7 parts of saline cistanches, 7 parts of levisticums, 2 parts of embryo nelumbinises, 2 parts of Folium Apocyni Venetves, 7 parts, lemon, 0.03 part of peppermint, 0.03 part of pig lung extract, 0.03 part of Chinese littleleaf box extract.
3. according to the arbitrary described a kind of Chinese medicine composition that is used for the treatment of idiopathic pulmonary hypertension disease of claim 1-2, it is characterized in that, the active ingredient of described pig lung extract is one or more in phosphatid ylcholine, DPPC, phosphatidyl-ethanolamine, phosphatidylserine, phosphinositides and sphingomyelins.
4. according to the preparation method of the arbitrary described a kind of Chinese medicine composition that is used for the treatment of idiopathic pulmonary hypertension disease of claim 1-2, it is characterized in that, comprise the following steps:
1) press formula ratio and weigh the larva of a silkworm with batrytis, saline cistanche, levisticum, embryo nelumbinis, Folium Apocyni Veneti, after cleaning, pulverize and cross 80 eye mesh screens through pulverizer, under 50-70 DEG C of condition, dry, dry in the air for subsequent use to room temperature;
2) mixture of step 1 is put into material-compound tank, add purified water according to the solid-liquid ratio of 1:10, decoct 40-60min, filter, get decoction liquor for the first time, filter residue continues to decoct;
3) filter residue of step 2 is added to purified water according to the solid-liquid ratio of 1:5, decoct 30-40min, filter, get decoction liquor for the second time, filter residue continues to decoct;
4) filter residue of step 3 is added to purified water according to the solid-liquid ratio of 1:3, and add the lemon of the stripping and slicing of formula ratio, decoct 10-20min, get decoction liquor for the third time, and with decoction liquor for the first time, decoction liquor merges for the second time;
5) in the mixing decoction liquor merging, add peppermint, pig lung extract and the Chinese littleleaf box extract of formula ratio to obtain medicine stoste, and add ethanol as dissolution aids, stir, sterilizing packing obtains described Chinese medicine composition liquid.
5. the preparation method of a kind of Chinese medicine composition that is used for the treatment of idiopathic pulmonary hypertension disease according to claim 4, is characterized in that, described Chinese medicine composition liquid is prepared into oral liquid or spray through conventional method.
6. the application of the Chinese medicine composition that a kind of as described in as arbitrary in claim 1-5 is used for the treatment of idiopathic pulmonary hypertension disease in preparation treatment idiopathic pulmonary hypertension medicine.
CN201610001498.2A 2016-01-05 2016-01-05 Traditional Chinese medicine composition for treating idiopathic pulmonary arterial hypertension and preparing method and application thereof Pending CN105596494A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610001498.2A CN105596494A (en) 2016-01-05 2016-01-05 Traditional Chinese medicine composition for treating idiopathic pulmonary arterial hypertension and preparing method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610001498.2A CN105596494A (en) 2016-01-05 2016-01-05 Traditional Chinese medicine composition for treating idiopathic pulmonary arterial hypertension and preparing method and application thereof

Publications (1)

Publication Number Publication Date
CN105596494A true CN105596494A (en) 2016-05-25

Family

ID=55977224

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610001498.2A Pending CN105596494A (en) 2016-01-05 2016-01-05 Traditional Chinese medicine composition for treating idiopathic pulmonary arterial hypertension and preparing method and application thereof

Country Status (1)

Country Link
CN (1) CN105596494A (en)

Similar Documents

Publication Publication Date Title
CN101612360A (en) The medicine of treatment hepatitis, liver cirrhosis, hepatocarcinoma
CN103520572A (en) Traditional Chinese composition used for treating atopic dermatitis as well as preparation method of composition
CN105166545A (en) Bovine compound feed and preparation method thereof
US7005146B2 (en) Complex prescription of chinese medicine for the treatment of extensive cancer
CN103877247B (en) Medicine being used for the treatment of decubital ulcer and preparation method thereof
CN104815192A (en) Pharmaceutical composition for treating hypertension and application of pharmaceutical composition
CN102106965B (en) Composition for treating acute injury of soft tissue and application thereof
CN105596861A (en) Pill used for treating adverse reaction after CT enhancement scanning and preparation method
CN1132616C (en) Traditional Chinese medicine for treating arthralgia-syndrome
CN104069443A (en) Traditional Chinese medicine for treating acute purulent osteomyelitis and preparation method of traditional Chinese medicine
CN108057115A (en) A kind of composition for treating inflammation of upper respiratory tract infection and preparation method thereof
CN103705760B (en) A kind of suppository preparation method for postpartum perineum pain
CN106266109A (en) A kind of Chinese medicine composition treating urinary system calculus and preparation method thereof
CN105521332A (en) Traditional Chinese medicinal composition for treating anal fissure, and preparation method and application thereof
CN105596494A (en) Traditional Chinese medicine composition for treating idiopathic pulmonary arterial hypertension and preparing method and application thereof
CN104367896B (en) A kind of pharmaceutical composition for treating Qi deficiency blood stasis type apoplexy and preparation method thereof
CN103977260B (en) A kind of medicine for treating sciatica and preparation method
CN106728645A (en) A kind of Traditional Chinese medicine compound composition of domestic animal lactagogue
CN107596337B (en) A kind of pharmaceutical composition for increasing short bowel syndrome Intestinal Mucosal Injury in Patients Undergoing absorption area
CN105963586A (en) Medicine for treating lung abscess and preparation method thereof
CN105395782A (en) Preparation method of aerosol inhalation medicine for treating chronic obstructive pulmonary disease
CN104815131A (en) Pharmaceutical composition for treating chicken gout and preparation method thereof
CN104083644A (en) Medicinal preparation beneficial for removing calculus
CN104027789A (en) Traditional Chinese medicine composition for treating cold retardation type jaundice of newborn babies and preparing method thereof
CN104127688A (en) Application of traditional Chinese medicine external-use plaster composition in preparation of drug used for preventing, relieving and/or treating osteoarticular diseases

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20160525