CN105596238B - A kind of leucoderma covering method that effect is more natural - Google Patents
A kind of leucoderma covering method that effect is more natural Download PDFInfo
- Publication number
- CN105596238B CN105596238B CN201610058887.9A CN201610058887A CN105596238B CN 105596238 B CN105596238 B CN 105596238B CN 201610058887 A CN201610058887 A CN 201610058887A CN 105596238 B CN105596238 B CN 105596238B
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- Prior art keywords
- leucoderma
- oil
- ester
- composition
- covering
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/432—Direct dyes
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
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Abstract
A kind of leucoderma covering method that effect is more natural, the method use a kind of completely new leucoderma box set, the leucoderma which individually packs comprising (i) first covers composition, contains leukoderma covering agent；(ii) the second composition comprising the unmixing oleaginous base of water individually packed.It by using box set of the invention, overcomes existing leukoderma covering agent and colours unnatural defect in edge, it is more accurate to realize the coloring of hickie edge, so that hickie position and normal skin solid colour, make the effect of leucoderma covering more natural.
Description
Technical field
The invention belongs to the cosmetic fields that leucoderma covers, and in particular to a kind of leucoderma covers box set and more natural
Leucoderma covering method.By using box set of the invention, it is accurate to realize the coloring of hickie edge so that disease sites reach with
Normal skin is bonded completely, natural visual effect, overcome existing leukoderma covering agent coloured in edge it is unnatural
Defect.
Background technique
Leucoderma (vitiligo) is a kind of common multiple pigmented dermatosis.The disease is de- with local or general hair property pigment
Mistake forms hickie and is characterized, and is the common skin diseases of an influence beauty, has the characteristics that easily to diagnose, treats hardly possible.Leucoderma is alive
There are generation in boundary various regions, and China is about 1%-2% there are about million people morbidity, disease incidence, are one of big chronic diseases of world's skin disease three.
Currently, the treatment method of leucoderma is varied, including Western medicine therapy, herbal treatment, physical therapy and operative treatment
Deng.However, pathogenesis is not yet completely clear at present, therefore effectively treats leucoderma wind facies since leucoderma disease is because of complexity
Work as difficulty.Since the affected part of leucoderma mostly occurs with head, face, neck and limb end, dressing is difficult to cover the white of patient
Spot, this significantly impacts the daily life of patients with vitiligo.
With the development of medical cosmetology, people start cosmetically making up to leucoderma or covering treatment, benefit
With the hyperchromic effect of certain ingredients, hickie is made to restore normal skin tone.External application leucoderma preparation common at present is roughly divided into as follows
Four classes: one, using psoralea corylifolia as the Chinese medicine of representative, this substance contains photosensitization active constituent, is shone after being applied to skin by light
Melanin production can be excited by penetrating；Two, corticosteroid formulations, corticosteroid hormone preparation can be to white caused by being immunoreacted
Purplish or white patches on the skin wind tells on；Three, beautifying drug, such as mustargen, dihydroxyacetone (DHA) etc.；Four, pigment toner, with cosmetic base
Form creme or paste, coated on hickie to play the role of covering.In these three types of external preparations, traditional Chinese medicine ingredients work
Slowly, and corticosteroid is as hormone, and long-time service can generate serious side effect.Therefore, can quickly add lustre to skin and
The drug class external preparation that apparent side effect will not be generated becomes the hot spot that hickie covers.For example, Zhang Qiliang is edited, " medicine beauty
Rong Xue ", 1996 the 1st edition, disclose 5% dihydroxyacetone (DHA) solution and 15% silver nitrate solution, repeat to apply and put on the skin, hickie can be made to contaminate
Color.Section sunrise institute etc., " therapy of vitiligo status ", " Chengde Medical College's journal ", the 2nd phase of volume 11 in 1994 disclose dihydroxy
Acetone is applied at hickie, the effect with horn cell, can generate color, and 5% dihydroxyacetone (DHA) is applied at hickie, for multiple daily,
Continuous to smear, color is able to maintain 2-3 days after coating.Guo Suizhang, " leucoderma medicament treatment is summarized ", " straits medicine ", 1998
The 3rd phase of volume 10, disclosing 2% dihydroxyacetone (DHA) complex liquid, (containing dihydroxyacetone (DHA) 2.0, diformazan is added in vitamin B1 200mg
Base sulfoxide 100ml) treatment leucoderma.Li Gang etc., " 5% 46 observation of curative effect of dihydroxyacetone (DHA) frost external curing leucoderma ", " work
Enterprise's doctor's periodical ", it the 2nd phase of volume 17 in 2004, discloses and 25g dihydroxyacetone (DHA) is dissolved in 475g cream base, be formulated as 5% 2
Hydroxypropanone- frost.
In recent years, having also appeared the patented technology that numerous leucoderma cover both at home and abroad.For example, disclosed in October, 2003
United States Patent (USP) authority US6630130B1, disclose one kind exempt from shine shine black preparation, said preparation include a kind of non-Cosmetic Ingredient and
The coloring system of containing oil soluble Cosmetic Ingredient and water-soluble Cosmetic Ingredient, the non-Cosmetic Ingredient can effectively be made by chemical reaction
Pigmenting of skin, the non-Cosmetic Ingredient includes dihydroxyacetone (DHA), and hickie can will be covered rapidly on the formulation application to skin.In
State's patent application 99114078.8 discloses a kind of externally-applied medicinal composition, by mustine hydrochlcride, dihydroxyacetone, psoralea corylifolia and red
Colored ethanol extract and Laurocapram composition.200610137625.8 also disclosing and a kind for the treatment of skin pigment reduction
External drug is made of alcohol, the fleece-flower root, psoralea corylifolia, the sophora bud, dihydroxyacetone.201210032196.3 disclosing a kind of white
Purplish or white patches on the skin wind covering agent is Masking sol or is covered white；The main composition of the Masking sol include: 1,2- propylene glycol, jojoba ester,
Preservative, surfactant, vitamin E acetate, C3H6O3, edible pigment and deionized water；The covering frost
Main composition includes: aluminum magnesium silicate, 1,2- propylene glycol, methyl p-hydroxybenzoate, propylparaben, imidazolidinyl
Urea, talcum powder, titanium dioxide, iron oxide, jojoba ester, vegetable fat, vitamin E acetate, stearyl alcohol, stearic acid, ten gather it is sweet
Oily monoleate, diolein, triethanolamine and deionized water.201210292092.6 disclosing a kind of leucoderma skin
Color Masking sol, consisting of: 50-100 parts of ginkgo leaf, 50-100 parts of duckweed, 50-100 parts of orange peel, 200-300 parts of 75% ethyl alcohol,
10-20 parts of copper chloride, 700-800 parts of sponge gourd water.201210303530.4 disclosing a kind of depth with leucoderma covering effect
Extra large marine algae extract, the raw material of the extract are as follows: 60-80 parts of cyanobacteria, 40-60 parts of green alga, 25-40 parts of brown alga, red algae 15-30
Part, 12-26 parts of bladder-wrack, 5-15 parts of beet.
Above-mentioned document, which is all described, is applied to affected part for leucoderma covering ingredient, makes hickie coloring to cover illness portion
Position.However affected skin can not only be made to colour due to covering active constituent, it can also make the color burn of normal skin, therefore use
How leucoderma applies affected skin edge when covering product becomes the key that success covers.And rely on existing coating
Mode, such as have no idea to be completely covered by hickie in the case where not influencing normal skin at all using cotton swab, soft head pen etc., because
This, need it is a kind of not only facilitated, but also effective cover product and covering method.
Summary of the invention
For overcome the deficiencies in the prior art, the present inventor is by for many years to leucoderma covering product the study found that white
Purplish or white patches on the skin wind covers being substantially property of product liquid preparation, including solution, emulsion etc..When these liquid contact skin when, on the one hand by
It is uneven in skin surface, on the other hand due to the surface tension effects of liquid, so that being unable to accurately control liquid painting
Deposited position.Due to the uncontrollability of edge coating, prevent disease sites with normal skin from being bonded completely, greatly shadow
Beauty is rung.The present inventor has found by test of many times, if first unmixing along one layer of water is applied in hickie edge outer skin
Oily matter, then not only can perfect coating hickie and normal skin edge, but also patient's surface covered can be improved.
Therefore, it is an object of the present invention to provide one kind can ideally cover the covering composition box of leucoderma,
The leucoderma individually packed comprising (i) first covers composition, contains leukoderma covering agent；Second individually pack include
The composition of the unmixing oleaginous base of water.
It is a further object of the present invention to provide a kind of cosmetic methods for covering leucoderma, including individually wrap using second first
The composition of dress applies one layer of oily matter unmixing with water in hickie edge outer skin, then applies and covers on hickie
Composition.
Box set according to the present invention, the leukoderma covering agent that wherein leucoderma covers in composition includes but is not limited to: color
Element, dihydroxyacetone (DHA), erythrulose, glyceraldehyde, silver nitrate, mustargen, corticosteroid, the Chinese medicine with chromogenesis extract
Object and its mixture.
Box set according to the present invention, wherein the leucoderma cover composition be liquid form, selected from solution, suspension,
Lotion.
Box set according to the present invention, wherein oleaginous base unmixing with water includes but is not limited to wax, oil, fat, fat
Acid, fatty alcohol, aliphatic ester, ether fatty acids, amide, polyacrylate, siloxanes and its mixture.
The wax can be vegetable wax, animal wax and mineral wax, including but not limited to: candelila wax, beeswax, cohune
Palmitic acid wax, spermaceti, lignite wax, ceresine, ceresin, paraffin, modified beeswaxes, grecian laurel fruit, castor wax, synthetic wax, microwax and its mixed
Close object wax.
The oil includes but is not limited to: three monooctyl ester of glycerol, glycerol three last of the ten Heavenly stems ester, the different stearyl ester of glycerol three, glycerol three oneself two
Acid esters, propylene glycol myristyl acetic acid esters, lanolin, lanolin oil, polybutene, isopropyl palmitate, isopropyl myristate,
Isostearic acid isopropyl acid, diethyl sebacate, diisopropyl adipate, Tocopheryl base ester, linoleic acid give birth to base ester, stearic acid
Cetyl ester, ethyl lactate, cetyl base ester, ricinoleic acid spermaceti base ester, oleyl alcohol, hexadecanol, hydroxy stearate are misery
Ester, octyldodecanol, wheat germ oil, hydrogenated vegetable oil, vaseline, modified wool rouge, branch hydro carbons, alcohols and esters, corn oil,
Cottonseed oil, olive oil, palm-kernel oil, rapeseed oil, safflower oil, George Simond wood oil, primrose oil, avocado oil, mineral oil, Butyrospermum
Rouge, octyl palmitate, the soybean oil of maleinization, diisopropyl dimerate and its mixture.
Box set according to the present invention, wherein the composition of oiliness matrix can be solid, semisolid or liquid, shape
It can be any geometry, preferably bar form.
Box set according to the present invention can also further include application leucoderma and cover composition and/or oleaginous base
Auxiliary tool.
Detailed description of the invention
Fig. 1 is neck hickie figure；
Fig. 2 is common smearing method effect picture；
Fig. 3 is hand hickie figure；
Fig. 4 is the effect picture of cosmetic method of the present invention.
Specific embodiment
Embodiment 1
The preparation of leucoderma covering solution
By dihydroxyacetone (DHA), water and alcohol, mixed according to the ratio of 5:93:2 to obtain the final product.
Embodiment 2
The preparation of composition comprising the unmixing oleaginous base of water
It takes beeswax, paraffin and each 20 parts of Brazil wax microwax to be heated to 100 DEG C to melting, is mixed 30 minutes,
The pure and mild 4 parts of lanolin oils of 2 parts of sher butters, 18 parts of octyldodecyls are added, stirs 40 minutes after mixing, injects the mixture into stick
In shape mold, it is cooled to room temperature to obtain the final product.
Effect example 1
The leucoderma of Example 1 covers 0.5 milliliter of solution, uses fine, soft fur pen in the neck disease sites of patients with vitiligo
It smears, effect coloring effect is shown in Fig. 2 after average time-consuming 45 minutes, 8 hours.
Effect example 2
It is smeared using the bar composition of embodiment 2 in the hand disease sites outer edge of patients with vitiligo, then takes reality
The leucoderma for applying example 1 covers 0.5 milliliter of solution, is smeared in disease sites using thick capillus pen, and average time-consuming is after 5 minutes, 8 hours
Effect coloring effect is shown in Fig. 4.
By above-mentioned experiment as it can be seen that by using the application makeup covering method, not only substantially increase coating cover
The efficiency of composition, and disease sites edge processing is very natural, almost without color difference.And use the painting generallyd use at present
Coating method, edge processing is extremely uneven, and it is unnatural to cover after stain.
Claims (4)
1. a kind of method for covering leucoderma using box set of non-treatment purpose, the box set includes: (i) first individually packs
Leucoderma covers composition, contains leukoderma covering agent；(ii) the second group comprising the unmixing oleaginous base of water individually packed
Object is closed, wherein the leukoderma covering agent is selected from dihydroxyacetone (DHA), erythrulose, glyceraldehyde and its mixture, the leucoderma
Covering composition is liquid form, is selected from solution, suspension, lotion, and the unmixing oleaginous base of water is selected from candelila wax, bee
Wax, Brazil wax, spermaceti, lignite wax, ceresine, paraffin, castor wax, synthetic wax, microwax, three monooctyl ester of glycerol, three last of the ten Heavenly stems of glycerol
Ester, the different stearyl ester of glycerol three, three adipate ester of glycerol, propylene glycol myristyl acetic acid esters, lanolin, polybutene, palmitinic acid are different
Propyl ester, isopropyl myristate, isostearic acid isopropyl acid, diethyl sebacate, diisopropyl adipate, Tocopheryl base ester,
Linoleic acid give birth to base ester, cetyl stearate, ethyl lactate, cetyl base ester, ricinoleic acid spermaceti base ester, oleyl alcohol,
Hexadecanol, octyl hydroxystearate, octyldodecanol, wheat germ oil, hydrogenated vegetable oil, vaseline, corn oil, cottonseed oil, olive
Olive oil, palm-kernel oil, rapeseed oil, safflower oil, George Simond wood oil, primrose oil, avocado oil, sher butter, octyl palmitate, horse
Come the soybean oil, diisopropyl dimerate and its mixture being acidified, the method for covering leucoderma includes using second first
The composition individually packed applies one layer of oily matter unmixing with water in hickie edge outer skin, then suffers from leucoderma
The leucoderma of the first packaging of coating covers composition on sick position.
2. according to the method described in claim 1, it is characterized in that the composition comprising the unmixing oleaginous base of water is solid
Body, semisolid or liquid.
3. according to the method described in claim 1, it is characterized in that the composition comprising the unmixing oleaginous base of water is stick
Shape form.
4. according to the method described in claim 1, it is characterized in that the box set, which further includes application leucoderma, covers combination
The auxiliary tool of object and/or oleaginous base.
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| CN201610058887.9A CN105596238B (en) | 2016-01-28 | 2016-01-28 | A kind of leucoderma covering method that effect is more natural |
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| CN201610058887.9A CN105596238B (en) | 2016-01-28 | 2016-01-28 | A kind of leucoderma covering method that effect is more natural |
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| CN105596238B true CN105596238B (en) | 2019-05-21 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6630130B1 (en) * | 2001-07-16 | 2003-10-07 | Pearl Grimes | Sunless tanning cream |
| CN1602839A (en) * | 2004-08-03 | 2005-04-06 | 彭少辉 | Long-lasting water proof and wearable leukoderma covering agent |
| CN1816319A (en) * | 2003-07-03 | 2006-08-09 | 宝洁公司 | Dual component skin care compositions that comprise a self-tanning agent |
| CN102525847A (en) * | 2012-02-14 | 2012-07-04 | 刘飞 | Leucoderma covering agent |
-
2016
- 2016-01-28 CN CN201610058887.9A patent/CN105596238B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6630130B1 (en) * | 2001-07-16 | 2003-10-07 | Pearl Grimes | Sunless tanning cream |
| CN1816319A (en) * | 2003-07-03 | 2006-08-09 | 宝洁公司 | Dual component skin care compositions that comprise a self-tanning agent |
| CN1602839A (en) * | 2004-08-03 | 2005-04-06 | 彭少辉 | Long-lasting water proof and wearable leukoderma covering agent |
| CN102525847A (en) * | 2012-02-14 | 2012-07-04 | 刘飞 | Leucoderma covering agent |
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Effective date of registration: 20191014 Address after: 720, 7th floor, building 2, No. 106, Majiabao East Road, Fengtai District, Beijing 100068 Patentee after: Beijing three li Biotechnology Co., Ltd. Address before: 100068, 106, Fengtai District, Majiabao East Road, Beijing ocean new natural 720 room Patentee before: Hu Fa Gang |