CN105596112A - Abdominal hernia repair mesh specially used for open surgery - Google Patents
Abdominal hernia repair mesh specially used for open surgery Download PDFInfo
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- CN105596112A CN105596112A CN201610051690.2A CN201610051690A CN105596112A CN 105596112 A CN105596112 A CN 105596112A CN 201610051690 A CN201610051690 A CN 201610051690A CN 105596112 A CN105596112 A CN 105596112A
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- mesh
- polypropylene
- hernia repair
- open surgery
- absorbable membrane
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
- A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
Abstract
The invention relates to an abdominal hernia repair mesh specially used for an open surgery, belonging to the technical field of medical consumables. The abdominal hernia repair mesh specially used for the open surgery comprises a polypropylene mesh and an absorbable membrane layer, wherein the surface of the polypropylene mesh is dipcoated with an absorbable coating, and the absorbable membrane layer is laminated on the polypropylene mesh; the area of the absorbable membrane layer is larger than that of the polypropylene mesh; the edge of the absorbable membrane layer is turned over and folded to the other side surface of the polypropylene mesh and then is fixed to form a locating bag. Compared with hot-pressing or molding by casting, the anti-adhesion patch enables polypropylene and the anti-adhesion membrane to be completely nested with each other, and microscopic examination proves no obvious boundary surface exists, so that the phenomenon of stratification does not occur. The abdominal hernia repair mesh is more easily used in the open surgery; the time of the surgery is shortened, the mesh is flatter after being implanted, the contact between the polypropylene and visceral organs such as intestinal canal and the like can be avoided to the utmost extent.
Description
Technical field
The present invention relates to the technical field of medical disposable material, more particularly, the present invention relates to a kind of open surgery specialAbdominal hernia repair mesh.
Background technology
Hernia is structural fascia tissue defect, and for example, taking stomach wall as example, organ or part organ, tissue or portion of tissue can be led toCrossing fascia tissue defect stretches out. Conventionally it is included in the weakening of the manadesma that contains organ or tissue in common structure, bulging or in factTear. Hernia has polytype. For example, when in hypogastric zone, hernia often comprises content in abdomen, as intestines or other tissue, theyEnter or pass through the damaged of stomach wall. Mesh-type patches is widely used in hernia reparation. At present conventional hernia patch be polyester webs sheet (asDacron, Mersilene), polypropylene mesh (as Marlex, Prolene etc.). But simple non-degraded net sheet can not be usedBe implanted in abdominal cavity, because internal organs may stick together with sticking patch, and cause serious complication, as sterility, chronic pelvicIntestinal fistula, intestinal obstruction etc. bitterly. Conventional solution is to insert physical barriers between the position of not wishing to occur adhesion. But,This barrier has caused the inner problem connecting of barrier, and reason is if barrier is prepared by non-absorbent material, itself soIt is exactly adhesion source; If absorbable, absorbing so must be non-inflammation, can not cause self adhesion.
Product that the ePTFE of Gore company exploitation is antiblocking layers (SurgicalMembrane) provideEffective tissue separate, but this material has and easily causes the shortcoming of must second operation taking out after infecting and infecting.In addition, because material crimp contraction is higher, mesothelial cell can not grow into, be so just difficult to form new peritonaeum (HarrellAG,NovitskyYW，PeindlRD，etal.Prospectiveevaluationofadhesionformationandshrinkageofintra-abdominalprostheticsinarabbitmodel.AmSurg2006，72：808-14.)。
Patent WO2009079271A2 discloses the Proceed Multilayer Network by the exploitation of Johnson&Johnson company of the U.S.Sheet, described Multilayer Network sheet is by polypropylene woven net sheet, PPDO (PDS) and oxidized regenerated cellulose film (ORC) threeLayer is composited, and its complex method is that the ORC mesh grid with certain water content and PDS film and the direct hot pressing of polypropylene net are answeredClose, increase the adhesion between each layer by water content, but the easy layering of sample prepared by the method, with puller system test can be byEach layer of separation, and pliability is not good enough, has much room for improvement with the compliance of stomach wall, and this has very strong foreign matter after can making net sheet implantSense.
Patent US6451032B1 has reported the Parietex net sheet of Tyco company exploitation, and described Parietex net sheet is by gatheringEthylene glycol terephthalate silk thread is woven into net sheet, the material compositions such as composite collagen, polyethylene glycol and glycerine; Wherein collagen is moltenLiquid carries out self-crosslinking by periodate oxidation, and forms the first tunic with polyethylene glycol and glycerine, second layer solution and firstLayer is basic identical, compound with PETG net sheet before gel, thereby has carried out the compound of multilayer. The methodIn have chemical reaction to participate in, and have the reagent of strong oxidizing property, and net sheet and the natural macromolecular collagen etc. that is difficult for film forming are directlyIn conjunction with, can not be in conjunction with very firm.
Patent CN101035574A and WO2005105172A1 disclose the Sepramesh net sheet by BARD company. DescribedSepramesh net sheet is for to be jointly woven into Double-level Reticulated sheet by polypropylene and polyglycolic acid silk thread, and it is that polyglycolic acid layer is being changedIn the hyaluronic acid/carboxymethyl cellulose of property and the polyglycol solution of modification, flood and form, wherein hyaluronic acid/carboxymethyl fibreDimension element is crosslinked by Carbodiimides crosslinking agent, and polyethyleneglycol derivative is the polyethylene glycol that end contains acrylate endedDerivative forms by light initiation polymerization in solution. The chemical reaction of multi-section has been passed through in the preparation of this product, comparatively complicated,For production process has increased larger cost.
The said goods or have that preparation technology is loaded down with trivial details, chemical reaction is many, easily layering, pliability is not good enough and preventing adhesiving effectHave the problems such as dispute, and price is very expensive.
Summary of the invention
In order to solve above-mentioned technical problem of the prior art, the object of the present invention is to provide a kind of open surgery specialWith abdominal hernia repair mesh.
The abdominal hernia repair mesh that open surgery is special, is characterized in that: being had by surface dip-coating can absorber coatingsPolypropylene mesh, and be pressed together on Absorbable membrane layer on described polypropylene mesh composition; And the face of described Absorbable membrane layerThe long-pending area that is greater than described polypropylene mesh, the edge of Absorbable membrane layer is folded to the another side of described polypropylene mesh and consolidatesBe shaped as Bag.
Wherein, the density of described polypropylene mesh is 20～80g/m2, thickness is 1～5mm; As preferably, described poly-The density of propylene net sheet is 20～50g/m2, thickness is 0.2～2mm. The single mesh area of described polypropylene mesh is 3～20mm2, be preferably 5～15mm2。
Wherein, described thickness that can absorber coatings is 1.0～20 μ m, and the thickness of Absorbable membrane layer is 5～200 μ m.
Wherein, on described Absorbable membrane layer, be provided with conduction hole, be preferably 0.8～1.5mm. Density be 0.2～5 hole/cm2, be preferably 0.5～2 hole/cm2。
Wherein, the edge of described Absorbable membrane layer is fixed on another of described polypropylene mesh by suture or fixatorSide.
Wherein, described abdominal hernia repair mesh is prepared by following methods:
1. polypropylene mesh is immersed in obtain that surface dip-coating has after can the molten fluid drying of absorber coatings can absorber coatingsPolypropylene mesh;
2. in mould, pour into and can absorb coating solution, after standing volatilization, obtain Absorbable membrane layer;
3. the surface dip-coating 1. step being obtained has polypropylene mesh heating that can absorber coatings to be pressed together on described can absorptionOn rete, leave standstill volatilization.
Wherein, 4. described method also comprises step: on described Absorbable membrane layer, beat conduction hole.
A second aspect of the present invention, also relates to the preparation method of the special abdominal hernia repair mesh of a kind of open surgery.
Preparation method of the present invention, comprises the following steps:
1. polypropylene mesh is immersed in obtain that surface dip-coating has after can the molten fluid drying of absorber coatings can absorber coatingsPolypropylene mesh;
2. in mould, pour into and can absorb coating solution, after standing volatilization, obtain Absorbable membrane layer;
3. the surface dip-coating 1. step being obtained has polypropylene mesh heating that can absorber coatings to be pressed together on described can absorptionOn rete, leave standstill volatilization.
Wherein, 4. described method also comprises step: on described Absorbable membrane layer, beat conduction hole.
The special abdominal hernia repair mesh of open surgery of the present invention compared with prior art has following usefulEffect:
In abdominal hernia repair mesh of the present invention, polypropylene and Antiadhesive film can be completely chimeric, see by microscopeExamine and there is no obvious boundary face, lamination can not occur. In the present invention, the polypropylene tissue excellent performance of growing into, can absorbAntiblocking layers can reduce the adhesion of internal organs and sticking patch; And the integrality of antiblocking layers can keep 30 days, 90-120 days complete afterwardsAbsorb; The extensibility (approximately 30%) with the physiological property of approaching, postoperative stomach wall compliance is good, and foreign body sensation is low; Antiadhesive film side bandHave mark clearly, the mistiming of avoiding performing the operation by polypropylene side towards internal organs.
Abdominal hernia repair mesh of the present invention is applicable to incisional hernia, pour hernie parastomiale, umbilical hernia, indirect inguinal hernia and peritonaeumThe abdominal-wall defect that thick tumor resection forms more easily uses in open surgery, saves operating time, and after implanting, net sheet is more flatWhole, avoid to greatest extent the internal organs such as intestinal tube to contact with polyacrylic simultaneously.
Brief description of the drawings
Fig. 1 is the structural representation of the special abdominal hernia repair mesh of open surgery of the present invention.
Fig. 2 is the structural representation of the special abdominal hernia repair mesh of open surgery of the present invention.
Fig. 3 places abdominal hernia repair mesh schematic diagram at damaged place.
Fig. 4 is the schematic diagram that utilizes the fixing abdominal hernia repair mesh of fixator.
Fig. 5 is the effect after abdominal hernia repair mesh is fixed.
Fig. 6 is the water absorption rate of the repair mesh for preparing of embodiment 2.
Fig. 7 is the contact angle of the repair mesh for preparing of embodiment 2.
Detailed description of the invention
Below with reference to specific embodiment to the special abdominal hernia repair mesh of open surgery of the present invention do intoThe elaboration of one step, more complete, accurate and dark to help those skilled in the art to have inventive concept of the present invention, technical schemeThe understanding entering.
As shown in the schematic diagram of Fig. 1, the abdominal hernia repair mesh that open surgery of the present invention is special, is soaked by surfaceScribble can absorber coatings polypropylene mesh 20, and the Absorbable membrane layer 10 being pressed together on described polypropylene mesh forms. AndThe area of described Absorbable membrane layer is greater than the area of described polypropylene mesh, and the edge of Absorbable membrane layer is folded to described polypropyleneThe another side of net sheet the fixing Bag that forms. As preferably, the edge of described Absorbable membrane layer is by suture or solidDetermine device and be fixed on the another side of described polypropylene mesh. Abdominal hernia repair mesh of the present invention is more easily at open handIn art, use, save operating time, after implanting, net sheet is more smooth, has avoided to greatest extent the internal organs such as intestinal tube and polypropylene simultaneouslyContact. As preferably, on described Absorbable membrane layer, be provided with conduction hole. Adherence preventing material causes surperficial conduction hole, canTissue fluid is drained into abdominal cavity, avoid tissue fluid to be deposited between sticking patch and stomach wall, reduce the swollen generation of slurries, to increase sticking patchWith the healing of tissue, reduce and infect simultaneously. Good biocompatibility be can absorb, regeneration and the reparation of peritonaeum are conducive to. DescribedThe density of polypropylene mesh is 20～80g/m2, thickness is 1～5mm; As preferably, the grammes per square metre of described polypropylene mesh is 20～80g/m2, thickness is 0.2～2mm; As preferably, the grammes per square metre of described polypropylene mesh is 20～50g/m2, thickness is 0.2～0.6mm. The single mesh area of described polypropylene mesh is 3～20mm2, be preferably 5～15mm2. Described can absorber coatingsThickness is 1.0～20 μ m, and the thickness of Absorbable membrane layer is 5～200 μ m. Polypropylene and Antiadhesive film can be complete in the present inventionChimeric, there is no obvious boundary face by microscopic examination, can there is not lamination. Show through clinical testing, described anti-The integrality of the Absorbable membrane layer of adhesion sticking patch in human body can keep more than 30 days, and the time absorbing is completely 90～120 days.Described Absorbable membrane layer is PLCL rete (poly-the third friendship-caprolactone copolymer) in the present invention, and described can absorber coatings be PLCLCoating: or as with improvement, the rete that described Absorbable membrane layer is made up of PLCL and MPEG2000-PLLA6000, described canAbsorber coatings is the coating being made up of PLCL and MPEG2000-PLLA6000.
In order to realize chimeric effect, technical scheme of the present invention has been abandoned conventional employing high concentration can absorbent solution dippingOr the method repeatedly applying obtains composite coating, and do not adopt conventional hot pressing method yet, but adopted following pointOne-step forming method. Specifically, preparation method of the present invention comprises the following steps: 1. polypropylene mesh is immersed in and can absorbs paintingLayer obtain after molten fluid drying surface dip-coating have can absorber coatings polypropylene mesh; 2. in mould, pour that can to absorb film molten intoLiquid, obtains Absorbable membrane layer after standing volatilization; 3. the surface dip-coating 1. step being obtained has polypropylene mesh that can absorber coatingsHeating is pressed together on described Absorbable membrane layer, leaves standstill volatilization, and heating is merged. As with improvement, 4. described method also comprises step:On described Absorbable membrane layer, beat conduction hole. As with improvement, 5. described method also comprises step: turnover, stitching, heat seal orUltra-sonic welded forms Bag.
Embodiment 1
Describe the special abdominal hernia of open surgery of the present invention in detail with a specific embodiment below and repair netThe manufacture craft of sheet. Described manufacture craft specifically comprises the following steps:
1. solution preparation
1.1 materials: PLCL pellet, acetone.
1.2 utensils: 1000ml volumetric flask, 250ml graduated cylinder, 250ml conical flask.
1.3 environment: 100,000 grades of dust proof workshops
1.4 utensil hot air sterilizations, 165 DEG C, 2 hours. Acetone rinse before using.
1.5 get PLCL pellet, after normal temperature, open, and pour in 1000ml volumetric flask and add acetone to be settled to 1000ml, cover tightlyBottle stopper is placed under 40 DEG C of environment and dissolves 48-72 hour, rocks during this time concussion, as masking PLCL solution for later use (PLCL concentration:0.1g/ml)。
1.6 get 100ml masking PLCL solution adds in 250ml conical flask, then adds 100ml acetone, and cover tightly bottle stopper and shake up,As coating PLCL solution for later use (PLCL concentration: 0.05g/ml).
3. merge
3.1 materials: masking PLCL solution, coating PLCL solution, polypropylene mesh.
3.2 utensils: 50ml graduated cylinder, 100ml graduated cylinder, tweezers, ePTFE plate
3.3 environment: humidity: < 20%; 20 DEG C of temperature: <.
3.4 prepare mould therefor and instrument 75% alcohol wipe and dry in the shade.
3.5 get polypropylene mesh, insert coating PLCL solution once after, natural drying, insert in the middle of ePTFE plate and flatten,Stand-by.
3.6 are placed in mould on table top, measure the masking PLCL solution of corresponding specification, pour mould levelling into, leave standstill 6 littleTime.
3.7 pave net sheet on PLCL film, adjust patrix and make it complete pressing net sheet, and temperature arranges 80 DEG C, heating30min。
4. Bag
4.1 utensils: cut-off knife, card punch
4.2 environment: 100,000 grades of dust proof workshops.
4.3 use cut-off knives are cut out and are removed sticking patch PLCL film around, retain mantle limit, and edge is folded to another of described polypropylene meshSide fixing (stitching, heat seal or ultrasonic wave) form Bag.
4.4 use card punchIn composite patch, punch, punch from one jiao of net sheet, interval 3 in transverse and longitudinal directionIndividual mesh holder, ensures being evenly distributed of hole.
6. clean
60% alcoholic solution ultrasonic cleaning 15 minutes, gently gets rid of, and dries.
7. packaging
8. vacuum drying
9. sterilizing
γ ray sterilization
When abdominal hernia repair mesh described in the present embodiment uses, place sticking patch at damaged place as shown in Figure 3, available hand orApparatus is paved along Bag; As shown in Figure 4, use fixator to fix, utilize mesh bag to save time, avoid repeatedly wearing at crochet hookThorn stomach wall. Fig. 5 shows the effect after fixing.
Comparative example 1
1. solution preparation
1.1 materials: PLCL pellet, acetone.
1.2 utensils: 1000ml volumetric flask, 250ml graduated cylinder, 250ml conical flask.
1.3 environment: 100,000 grades of dust proof workshops
1.4 utensil hot air sterilizations, 165 DEG C, 2 hours. Acetone rinse before using.
1.5 get PLCL pellet, after normal temperature, open, and pour in 1000ml volumetric flask and add acetone to be settled to 1000ml, cover tightlyBottle stopper is placed under 40 DEG C of environment and dissolves 48-72 hour, rocks during this time concussion, as PLCL solution for later use (PLCL concentration: 0.1g/ml)。
2. merge
2.1 materials: PLCL solution, polypropylene mesh.
2.2 utensils: 50ml graduated cylinder, 100ml graduated cylinder, tweezers, ePTFE plate
2.3 environment: humidity: < 20%; 20 DEG C of temperature: <.
2.4 prepare mould therefor and instrument 75% alcohol wipe and dry in the shade.
2.5 get polypropylene mesh and are placed in mould, and cast PLCL solution, smears evenly, natural drying, insertsFlatten in the middle of ePTFE plate, leave standstill volatilization 24 hours, obtain a side and have the polypropylene composite materials net sheet of PLCL rete.
3. punching
3.1 utensils: cut-off knife, card punch
3.2 environment: 100,000 grades of dust proof workshops.
3.3 use card punchIn composite patch, punch, punch from one jiao of net sheet, interval 3 in transverse and longitudinal directionIndividual mesh holder, ensures being evenly distributed of hole.
4. clean
60% alcoholic solution ultrasonic cleaning 15 minutes, gently gets rid of, and dries.
5. packaging
6. vacuum drying
7. sterilizing
γ ray sterilization
Embodiment 1 is immersed in respectively in physiological saline with the sticking patch that comparative example 1 prepares, places contrast after 30 hoursExample 1 is made the sticking patch respectively obtaining and can observe the phenomenon of absciss layer, and the sticking patch of embodiment 1 is not stratified. In addition, prepared by comparative example 1The repair mesh hardness obtaining is bigger than normal, and elasticity deficiency, and feel is poor, and hard thing sense is strong.
Adopting when operation weight is that White Rabbit between 2.5-3.5Kg carries out surgical repair operation. When operation by White RabbitAnesthesia, at the full depth muscle layer of left abdomen excision 20mm × 20mm, then uses the simple polypropylene sticking patch of 30mm × 30mm(product that gone on the market,4 of positive controls), Parietex sticking patch (product that gone on the market, 8 of negative control products), implementComposite patch (10) in sticking patch (10) and embodiment 6 in example 1 is repaired, with 4-Oprolene suture, sticking patch is solidFix on stomach wall, sew up a wound. 3 months after operation is implemented euthanasia and assesses its prevent adhesion performance animal used as test, comprises adhesionArea and adhesion incidence. Sticking patch with adhesion is carried out to vertical high-definition camera, and soft with Photoshop and SiconImagePart is processed, and to carry out the calculating of adhesion area, and carries out classification, adhesion face integration stages standard: 0 point-there is no an adhesion; 1 point-≤ 25% surface is with adhesion, and average 12.5%; 2 points-26-50% surface is with adhesion, and average 37.5%; 3 points-51-75%Surperficial with adhesion, average 63%; 4 points of->=76% surfaces are with adhesion, and average 88%. Adhesion incidence is what stick togetherSize of animal and on the same group the ratio percentage of total quantity. Result is as shown in table 1.
Table 1
Embodiment 2
1. solution preparation
1.1 materials: PLCL, MPEG2000-PLLA6000, acetone.
1.2 utensils: 1000ml volumetric flask, 250ml graduated cylinder, 250ml conical flask.
1.3 environment: 100,000 grades of dust proof workshops
1.4 utensil hot air sterilizations, 165 DEG C, 2 hours. Acetone rinse before using.
1.5 prepare 10,30 or 50 grams of MPEG2000-PLLA6000, after normal temperature, open, and pour in 1000ml volumetric flask, addEnter acetone, cover tightly bottle stopper and be placed under 40 DEG C of environment and dissolve, then add 90,70,50 grams of PLCL stirring and dissolving complete, and add thirdKetone is settled to 1000mL, as masking mixed solution stand-by (mass ratio of PLCL and MPEG2000-PLLA6000 9: 1,7 respectively:3、1∶1)。
1.6 get 100ml masking mixed solution adds in 250ml conical flask, then adds 100ml acetone, and cover tightly bottle stopper and shake up,Stand-by as coating mixed solution.
2. merge
2.1 materials: masking mixed solution, coating mixed solution, polypropylene mesh.
2.2 utensils: 50ml graduated cylinder, 100ml graduated cylinder, tweezers, ePTFE plate
2.3 environment: humidity: < 20%; Temperature: room temperature.
2.4 prepare mould therefor and instrument 75% alcohol wipe and dry in the shade.
2.5 get polypropylene mesh, insert coating mixed solution once after, natural drying, insert in the middle of ePTFE plate and flatten,Stand-by.
2.6 are placed in mould on table top, measure the masking mixed solution of corresponding specification, pour mould levelling into, leave standstill 6 littleTime.
2.7 pave net sheet on PLCL film, adjust patrix and make it complete pressing net sheet, and temperature arranges 80 DEG C, heating30min。
3. clean
60% alcoholic solution ultrasonic cleaning 15 minutes, gently gets rid of, and dries.
The water absorption rate of the sticking patch that embodiment 2 prepares and contact angle are respectively as shown in Figures 6 and 7. Compared with PLCL film, noOnly, improved water absorption rate, but also unexpected reduction contact angle, especially adopt MPEG-2000-PLLA5000 withIts contact angle of abdominal hernia patching material that the mass mixings such as PLCL obtain is less than 20 °
For the ordinary skill in the art, specific implementation of the present invention is not subject to the restrictions described above, as long asAdopted the improvement of the various unsubstantialities that method of the present invention design and technical scheme carry out, or without improvement by of the present inventionDesign and technical scheme directly apply to other occasion, all within protection scope of the present invention.
Claims (8)
1. the special abdominal hernia repair mesh of open surgery, is characterized in that: being had by surface dip-coating can absorber coatingsPolypropylene mesh, and be pressed together on the Absorbable membrane layer composition on described polypropylene mesh; And the area of described Absorbable membrane layerBe greater than the area of described polypropylene mesh, the edge of Absorbable membrane layer is folded to the another side of described polypropylene mesh and fixesForm Bag.
2. the special abdominal hernia repair mesh of open surgery according to claim 1, is characterized in that: described absorptionCoating is poly-the third friendship-caprolactone coating, and described Absorbable membrane layer is poly-the third friendship-caprolactone rete.
3. the special abdominal hernia repair mesh of open surgery according to claim 2, is characterized in that: described polypropyleneThe density of net sheet is 20～50g/m2, thickness is 0.2～2mm, single mesh area is 5～15mm2。
4. the special abdominal hernia repair mesh of open surgery according to claim 1, is characterized in that: described absorptionThe edge of rete is fixed on the another side of described polypropylene mesh by suture or fixator.
5. the special abdominal hernia repair mesh of open surgery according to claim 1, is characterized in that: described absorptionOn rete, be provided with conduction hole; The diameter of conduction hole is 0.5～5mm.
6. the special abdominal hernia repair mesh of open surgery according to claim 1, is characterized in that: described prevent adhesionSticking patch is prepared by following methods:
1. polypropylene mesh is immersed in obtain after can the molten fluid drying of absorber coatings surface dip-coating have can absorber coatings poly-thirdAlkene net sheet;
2. in mould, pour into and can absorb coating solution, after standing volatilization, obtain Absorbable membrane layer;
3. the surface dip-coating 1. step being obtained has polypropylene mesh heating that can absorber coatings to be pressed together on described Absorbable membrane layerUpper, leave standstill volatilization.
7. the preparation method of the special abdominal hernia repair mesh of open surgery claimed in claim 1, described in it is characterized in thatPreparation method comprises the following steps:
1. polypropylene mesh is immersed in obtain after can the molten fluid drying of absorber coatings surface dip-coating have can absorber coatings poly-thirdAlkene net sheet;
2. in mould, pour into and can absorb coating solution, after standing volatilization, obtain Absorbable membrane layer;
3. the surface dip-coating 1. step being obtained has polypropylene mesh heating that can absorber coatings to be pressed together on described Absorbable membrane layerUpper, leave standstill volatilization.
8. preparation method claimed in claim 7, is characterized in that 4. described method also comprises step: at described Absorbable membrane layerThe upper conduction hole of beating.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610051690.2A CN105596112B (en) | 2016-01-25 | 2016-01-25 | The dedicated ventral hernia repair mesh sheet of open surgery |
| US15/142,922 US10350045B2 (en) | 2016-01-25 | 2016-04-29 | Repair material with multi-purpose for abdominal wall hernia |
| EP16168494.9A EP3195884B1 (en) | 2016-01-25 | 2016-05-05 | Repair material with multi-purpose for abdominal wall hernia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610051690.2A CN105596112B (en) | 2016-01-25 | 2016-01-25 | The dedicated ventral hernia repair mesh sheet of open surgery |
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| CN105596112A true CN105596112A (en) | 2016-05-25 |
| CN105596112B CN105596112B (en) | 2018-06-15 |
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| CN201610051690.2A Active CN105596112B (en) | 2016-01-25 | 2016-01-25 | The dedicated ventral hernia repair mesh sheet of open surgery |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106178143A (en) * | 2016-08-30 | 2016-12-07 | 常州市康蒂娜医疗科技有限公司 | A kind of anti biological sticking patch and preparation method |
| CN110464505A (en) * | 2019-07-12 | 2019-11-19 | 上海大学 | A kind of enhanced reticular structure stomach wall of elasticity repairs sticking patch and preparation method thereof |
| CN112023151A (en) * | 2020-09-28 | 2020-12-04 | 郑州大学第一附属医院 | Postoperative suture-free drainage device |
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| CN102217981A (en) * | 2011-05-16 | 2011-10-19 | 北京天助畅运医疗技术股份有限公司 | Multi-layer hernia repairing patch and preparation method thereof |
| CN202589706U (en) * | 2012-05-07 | 2012-12-12 | 高鹏志 | Inguinal hernia two-in-one repairing piece |
| CN202682096U (en) * | 2012-05-17 | 2013-01-23 | 天津市康尔医疗器械有限公司 | Absorbable endocranium repair patch |
| CN102908676A (en) * | 2012-10-19 | 2013-02-06 | 东华大学 | Hollowed PP/PVDF (Polypropylene/Polyvinylidene Fluoride) composite hernia sticking patch and preparation method thereof |
| US20130317527A1 (en) * | 2012-04-10 | 2013-11-28 | Ethicon, Inc. | Single plane tissue repair patch having a locating structure |
| CN103932818A (en) * | 2014-04-08 | 2014-07-23 | 张伟 | Hernia repair patch and lead-in device for hernia repair patch |
| CN104706442A (en) * | 2015-03-16 | 2015-06-17 | 克力木·阿不都热依木 | Patch special for esophageal hiatus hernia |
| CN105120797A (en) * | 2013-03-11 | 2015-12-02 | 强生医疗有限责任公司 | Surgical implant |
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| CN102217981A (en) * | 2011-05-16 | 2011-10-19 | 北京天助畅运医疗技术股份有限公司 | Multi-layer hernia repairing patch and preparation method thereof |
| US20130317527A1 (en) * | 2012-04-10 | 2013-11-28 | Ethicon, Inc. | Single plane tissue repair patch having a locating structure |
| CN202589706U (en) * | 2012-05-07 | 2012-12-12 | 高鹏志 | Inguinal hernia two-in-one repairing piece |
| CN202682096U (en) * | 2012-05-17 | 2013-01-23 | 天津市康尔医疗器械有限公司 | Absorbable endocranium repair patch |
| CN102908676A (en) * | 2012-10-19 | 2013-02-06 | 东华大学 | Hollowed PP/PVDF (Polypropylene/Polyvinylidene Fluoride) composite hernia sticking patch and preparation method thereof |
| CN105120797A (en) * | 2013-03-11 | 2015-12-02 | 强生医疗有限责任公司 | Surgical implant |
| CN103932818A (en) * | 2014-04-08 | 2014-07-23 | 张伟 | Hernia repair patch and lead-in device for hernia repair patch |
| CN104706442A (en) * | 2015-03-16 | 2015-06-17 | 克力木·阿不都热依木 | Patch special for esophageal hiatus hernia |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106178143A (en) * | 2016-08-30 | 2016-12-07 | 常州市康蒂娜医疗科技有限公司 | A kind of anti biological sticking patch and preparation method |
| CN106178143B (en) * | 2016-08-30 | 2019-03-29 | 常州市康蒂娜医疗科技有限公司 | One kind prevents adhesion biological sticking patch and preparation method |
| CN110464505A (en) * | 2019-07-12 | 2019-11-19 | 上海大学 | A kind of enhanced reticular structure stomach wall of elasticity repairs sticking patch and preparation method thereof |
| CN112023151A (en) * | 2020-09-28 | 2020-12-04 | 郑州大学第一附属医院 | Postoperative suture-free drainage device |
| CN112023151B (en) * | 2020-09-28 | 2022-11-22 | 郑州大学第一附属医院 | Postoperative suture-free drainage device |
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| CN105596112B (en) | 2018-06-15 |
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