CN105582335A - Dendrobe healthcare product - Google Patents
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- CN105582335A CN105582335A CN201610154057.6A CN201610154057A CN105582335A CN 105582335 A CN105582335 A CN 105582335A CN 201610154057 A CN201610154057 A CN 201610154057A CN 105582335 A CN105582335 A CN 105582335A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
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- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to the field of healthcare products and discloses a dendrobe healthcare product. The dendrobe healthcare product is prepared from the active ingredients including, by weight, 2 parts of dendrobe, 40 parts of hyptis suaveolens, 35 parts of wild hops, 40 parts of pandanus tectorius, 28 parts of rhizome of Clematis quinquefoliolata and 30 parts of hypericum erectum. It is further disclosed that the dendrobe healthcare product has a blood glucose reducing effect.
Description
Technical field
The present invention relates to traditional Chinese medicine health care product technical field, be specifically related to a kind of preparation method and application of dendrobium health-care product.
Background technology
Diabetes are one group of metabolic diseases taking hyperglycaemia as feature. Hyperglycaemia is due to defect of insulin secretion or its biologyAct on impairedly, or both have concurrently and cause. Long-standing hyperglycaemia when diabetes, causes various tissues, particularly eye, kidney,Chronic lesion, the dysfunction of heart, blood vessel, nerve.
Summary of the invention
Goal of the invention: in order to address the above problem, to the object of the present invention is to provide a kind of preparation method of dendrobium health-care product and answerWith.
Technical scheme: the object of the invention is to realize by following scheme:
A kind of dendrobium health-care product, its contained active component is prepared from by following raw materials in part by weight proportioning: 2 parts of the stems of noble dendrobium, mountain40 parts of perfume, 35 parts of cordateleaf European hop flowers, 40 parts of Lu Dou le, 28 parts of willow leaf spinyleaf pricklyash roots, 30 parts of hypericum erectums.
Described dendrobium health-care product, preparation method's step is: get above-mentioned other medicinal materials merging except the stem of noble dendrobium, boiling twice,Collecting decoction, while being concentrated into 65 DEG C, relative density is 1.10-1.20, adds ethanol, stirs, and makes containing by volume percentage of alcohol amountCalculating reaches 65-85%, leaves standstill, and filters, and when filtrate decompression is concentrated into 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, willConcentrate spraying is dry, and gained granular powder is broken into dry extract, adds the stem of noble dendrobium and auxiliary material, makes required preparation.
Described dendrobium health-care product, in preparation method, decocting condition is: amount of water is that the 8-12 of medicinal material weight doubly measures for the first time, decoctsBoil 1-2h, amount of water is that the 6-10 of medicinal material weight doubly measures for the second time, decocts 1-2h.
Described dendrobium health-care product, the drying condition of spraying in preparation method is: EAT is 90-110 DEG C, and leaving air temp is60-90 DEG C, temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
Described dendrobium health-care product is in the application of preparing in health-caring product capable of reducing blood sugar.
The above-mentioned stem of noble dendrobium (formal name used at school: DendrobiumnobileLindl), has another name called lofty or bottomless palpus, bracketplant, Lin Lan, taboo life, Jin Chai flowerDeng. Stem is upright, meat shape plumpness, and slightly flat is cylindrical, long 10～60 centimetres, slightly reaches 1.3 centimetres. Medicinal plant, nature and flavorSweet light micro-salty, cold, return stomach, kidney, lung channel. Reinforcing stomach reg fluid is nourishing Yin and clearing heat. Hinder body fluid deficiency for the moon, dry polydipsia, food is few dryVomit, abnormal heat after being ill, order is secretly not clear. Stem of noble dendrobium flower appearance gracefulness, exquisite lovely, pattern is bright-coloured, and fragrant odour is called that " four is largeOne of view and admire ocean flower ".
Bee saage is Labiatae bee saage platymiscium bee saage Hyptissuaveolens (L.) Poir., with all herbal medicine. Xia Qiu gathers,Dry in the shade or using fresh herb. Dispelling wind dampness removing, the promoting the circulation of qi stasis of blood of faling apart. For cold headache, gastroenteritis, dysentery, abdominal distension; Treating swelling and pain by traumatic injury is controlled in external application,Traumatic bleeding, carbuncle sore tumefacting virus, worm snake bite, eczema, dermatitis.
Cordateleaf European hop flower, Latin is called HumuluslupulusL.Var.Cordifolius (Miq.) Maxim., is moraceae plants China hopsFlower. Bitter, property is flat. Enter the heart, lung, stomach warp. Stomach invigorating, calmness, treating tuberculosis. Control indigestion, do not feel like eating, hysteria,Insomnia card, tuberculosis.
Lu Dou le is Pandanaceae screw pine Lu Dou le Pandanustectorius (L.) Parkins., with root, fruit andFruit stone is used as medicine. Root can be adopted the whole year, and fruit is adopted winter, using fresh herb or dry. Inducing sweat and dispelling exogenous evils, clearing heat and detoxicating, sharp aquation phlegm. Root: senseEmit heating, nephritic dropsy, urinary infection, lithangiuria, hepatitis, cirrhotic ascites, Infantile Summer Fever, eye keratitis.Really: dysentery, cough. Fruit stone: orchitis, hemorrhoid. The present invention is used as medicine with root.
Willow leaf spinyleaf pricklyash root is complete stool or the root of ranunculaceae plant five leaf clematis. Latin formal name used at school isClematis-quinquefoliolata-Hutch, dispels rheumatism, in temperature, regulates the flow of vital energy, and blood stasis removing analgesic. For Fengshi Guanjie pain, fall and beatDamage, bruise, stomachache, dysmenorrhoea, antimigraine, neuralgia, facioplegia, fish-bone fishbone larynx. The present invention is used as medicine with complete stool.
Hypericum erectum is the herb of perennial dicotyledon medicine Garcinia maingayii hypericum erectum. Up to 30～60 centimetres, Glabrous.Stem is cylindrical. Be born in hill. All there is distribution the greater part, the whole nation. Regulating menstruation, hemostasis, removing toxicity for detumescence. For irregular menstruation, digestionGastrointestinal hemorrhage, spits blood, bleeding from five sense organs or subcutaneous tissue; Traumatism and bleeding is controlled in external application, furuncle swelling toxin, venomous snake bite. All the other are pharmacopeia kind.
Beneficial effect: bee saage of the present invention, cordateleaf European hop flower dispelling wind dampness removing, the loose stasis of blood of promoting the circulation of qi is monarch drug in a prescription, Lu Dou le, willow leaf spinyleaf pricklyash root, littleCapsule of weeping forsythia profit aquation phlegm is ministerial drug, and the stem of noble dendrobium is adjuvant, full side compatibility mutually, and clearing heat and detoxicating, reinforcing stomach reg fluid, nourishing Yin and clearing heat, controlTreat diabetes successful.
Detailed description of the invention
Form by the following examples, is described in further detail foregoing of the present invention again, but this should not understoodFor the scope of the above-mentioned theme of the present invention only limits to following example, all technology realizing based on foregoing of the present invention all belong to thisScope of invention.
Embodiment 1: get bee saage 40g, cordateleaf European hop flower 35g, Lu Dou le 40g, willow leaf spinyleaf pricklyash root 28g, hypericum erectum 30g medicinal material is mixedClose, boiling twice, adds water for the first time as 8 times of amounts of medicinal material weight, decocts 1.5h, adds water for the second time as medicinal material weight6 times of amounts, decoct 1h, and collecting decoction filters, and filtrate is concentrated into relative density 1.10 (65 DEG C), add appropriate ethanol and make containing alcoholAmount (volume fraction) reaches 65%, stirs, and leaves standstill 24 hours, filters, and filtrate recycling ethanol is also concentrated into relative density 1.10The medicinal extract of (65 DEG C), spray-dried (condition is that EAT is 100 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 70 DEG C,Atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s. ), be ground into dry extract, then add Dendrobium 2g, dextrin 50g,Wetting with appropriate 80% ethanol, softwood processed, crosses 14 mesh sieves and granulates, and 70 DEG C dry, and the whole grain of 60 orders, obtains granule.
Embodiment 2: get bee saage 40g, cordateleaf European hop flower 35g, Lu Dou le 40g, willow leaf spinyleaf pricklyash root 28g, hypericum erectum 30g medicinal material is mixedClose, boiling adds water for twice, the time as 10 times of amounts of medicinal material weight, decocts 2h, adds water for the second time as 8 of medicinal material weightDoubly amount, decocts 1h, and collecting decoction filters, and filtrate is concentrated into relative density 1.15 (65 DEG C), adds appropriate ethanol and makes containing alcohol amount(volume fraction) reaches 75%, stirs, and leaves standstill 24 hours, filters, and filtrate recycling ethanol is also concentrated into relative density 1.25The medicinal extract of (65 DEG C), spray-dried (condition is that EAT is 120 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 80 DEG C,Atomizing pressure is 0.3 MPa, and spray velocity is 7.5/s. ), be ground into dry extract 50g, add Dendrobium 2g, starch 50g,Mix, wetting with appropriate 80% ethanol, softwood processed, crosses 30 mesh sieves and granulates, and is dried in 70～80 DEG C, whole with 60 mesh sievesGrain, compressing tablet, dressing, packing, external packing, censorship is qualified, obtains finished product.
Embodiment 3: get bee saage 40g, cordateleaf European hop flower 35g, Lu Dou le 40g, willow leaf spinyleaf pricklyash root 28g, hypericum erectum 30g medicinal material is mixedClose, boiling twice, adds water for the first time as 10 times of amounts of medicinal material weight, decocts 1.5h, adds water for the second time as medicinal material weight8 times of amounts, decoct 1.5h, collecting decoction, filter, filtrate is concentrated into relative density 1.15 (65 DEG C), adds appropriate ethanol and makesReach 75% containing alcohol amount (volume fraction), stir, leave standstill 24 hours, filter, filtrate recycling ethanol is also concentrated into relative densityThe medicinal extract of 1.25 (65 DEG C), spray-dried (condition is that EAT is 120 DEG C, and leaving air temp is 90 DEG C, temperature of chargeBe 90 DEG C, atomizing pressure is 0.4 MPa, and spray velocity is 7.5/s. ), be ground into dry extract, cross sieve No. 6, add stoneDry measure used in former times powder 2g, starch 50g, reinstalls No. 1 capsule and gets final product to obtain finished product.
Hypoglycemic pharmacodynamic study falls in embodiment 4, the present invention
Animal used as test: (20 ± 2g) is male for Kunming mouse, and Shanghai Slac Experimental Animal Co., Ltd. provides, production permitCard: SCXK (Shanghai) 2007-0005.
Experimental agents: press above-described embodiment 1 method preparation. Every day, every 20g mouse stomach, pressed Mice Body restatement, low doseAmount, middle dosage and high dose are respectively 5g crude drug amount/kg, 10g crude drug amount/kg and 20g crude drug amount/kg.
Positive drug diabetes pill, Guangzhou Zhongyi Medicine Industry Co., Ltd's product, lot number 20140310, specification is 30g/ bottle, every bottle of l20Grain, 10 is 2.5g, and patient uses general each 10, and every day 2 times, i.e. people's consumption per day 5g, is equivalent to every 20g littleMouse consumption is 5*0.0026=0.013g, calculates by per kilogram mouse, and positive drug group gives diabetes pill 0.65g/kg.
Instrument and reagent: alloxan (C4H2N2O4·H2O, molecular weight 160.08), blood glucose meter, full automatic biochemical apparatus, 721Spectrophotometer, ELIASA, balance.
Adaptability was raised after 1 day, got at random 10 mouse as normal group, and another 90 animal fasting 3-5 hour survey on an empty stomachBlood sugar, as this batch of animal basis blood glucose value. Animal fasting subsequently 24 hours (freely drinking water), lumbar injection alloxan(with front fresh preparation) 130mg/kg modeling, animal fasting 5 hours after 5 days, surveys blood sugar, blood glucose value 10～25mmol/LFor hyperglycemia model success animal.
Select 40 of hyperglycemia model animals, by the blood sugar level grouping of fasting 3-5 hour, select at random 1 model control group and 4Individual dosage group (the poor 1.1mmol/L that is not more than between group), every group of 10 animals, dosage group gives variable concentrations given the test agent, modelControl group gives solvent, continuous 30 days, surveys fasting blood sugar (fasting is with before testing), more each treated animal blood glucose value and blood sugarDecline percentage.
The effect ((X scholar D) that the present invention declines to the sugared model mice blood sugar of height
With relatively * * * p < 0.001 of normal group, with relatively ###p < 0.001 of model group, with the comparison of positive drug group￥p<0.05。
Medicine of the present invention has hypoglycemic effect to hyperglycaemia mouse, significantly reduces explanation with blood glucose value after model group comparative experimentsThe present invention has hypoglycemic effect. The high dose group of medicine of the present invention is compared with positive drug group, and blood sugar declines significant difference, saysThe effect of bright medicine of the present invention is better than positive drug.
Claims (5)
1. a dendrobium health-care product, is characterized in that, its contained active component is prepared by following raw materials in part by weight proportioningForm: 2 parts of the stems of noble dendrobium, 40 parts of bee saages, 35 parts of cordateleaf European hop flowers, 40 parts of Lu Dou le, 28 parts of willow leaf spinyleaf pricklyash roots, hypericum erectum30 parts.
2. dendrobium health-care product as claimed in claim 1, is characterized in that, preparation method's step is: get above-mentioned except the stem of noble dendrobiumOuter other medicinal materials merge, boiling twice, and collecting decoction, while being concentrated into 65 DEG C, relative density is 1.10-1.20, addsEnter ethanol, stir, make containing alcohol amount by volume percentage calculation reach 65-85%, leave standstill, filter, filtrate decompression is concentrated into65 DEG C time, relative density is 1.20-1.30 and reclaims ethanol, and by dry concentrate spraying, gained granular powder is broken into dry extractPowder, adds the stem of noble dendrobium and auxiliary material, makes required preparation.
3. dendrobium health-care product as claimed in claim 2, is characterized in that, in preparation method, decocting condition is: for the first timeAmount of water is that the 8-12 of medicinal material weight doubly measures, and decocts 1-2h, and amount of water is that the 6-10 of medicinal material weight doubly measures for the second time, decoctsBoil 1-2h.
4. dendrobium health-care product as claimed in claim 2, is characterized in that, the drying condition of spraying in preparation method is: enterAir temperature is 90-110 DEG C, and leaving air temp is 60-90 DEG C, and temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 millionHandkerchief, spray velocity is 1-10ml/s.
5. the application of dendrobium health-care product in health-caring product capable of reducing blood sugar as claimed in claim 1.
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| CN106107483A (en) * | 2016-06-28 | 2016-11-16 | 禹州市思源实业有限公司 | A kind of dendrobium nutrient setting stick face and preparation method thereof |
| CN108514111A (en) * | 2018-03-05 | 2018-09-11 | 安徽省霍山县福康石斛开发有限公司 | A kind of preparation method of nourishing blood and liver stem of noble dendrobium cake |
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| CN106107483A (en) * | 2016-06-28 | 2016-11-16 | 禹州市思源实业有限公司 | A kind of dendrobium nutrient setting stick face and preparation method thereof |
| CN108514111A (en) * | 2018-03-05 | 2018-09-11 | 安徽省霍山县福康石斛开发有限公司 | A kind of preparation method of nourishing blood and liver stem of noble dendrobium cake |
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Application publication date: 20160518 |