CN105579581A - 具有优化的a凸出物的重组载体 - Google Patents

Info

Publication number

CN105579581A

CN105579581A CN201480053358.9A CN201480053358A CN105579581A CN 105579581 A CN105579581 A CN 105579581A CN 201480053358 A CN201480053358 A CN 201480053358A CN 105579581 A CN105579581 A CN 105579581A

Authority

CN

China

Prior art keywords

sequence

restructuring

replication competent

retrovirus

competent type

Prior art date

2013-08-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000013598 vector Substances 0.000 title claims abstract description 96
• 241001430294 unidentified retrovirus Species 0.000 claims abstract description 251
• 102000040430 polynucleotide Human genes 0.000 claims abstract description 153
• 108091033319 polynucleotide Proteins 0.000 claims abstract description 153
• 239000002157 polynucleotide Substances 0.000 claims abstract description 153
• 230000010076 replication Effects 0.000 claims abstract description 126
• 101710177291 Gag polyprotein Proteins 0.000 claims abstract description 9
• 101710125418 Major capsid protein Proteins 0.000 claims abstract description 9
• 108010089520 pol Gene Products Proteins 0.000 claims abstract description 8
• 210000004027 cell Anatomy 0.000 claims description 276
• 108090000623 proteins and genes Proteins 0.000 claims description 157
• 108020004684 Internal Ribosome Entry Sites Proteins 0.000 claims description 156
• 241000700605 Viruses Species 0.000 claims description 147
• 150000007523 nucleic acids Chemical class 0.000 claims description 98
• 230000014509 gene expression Effects 0.000 claims description 93
• 239000002773 nucleotide Substances 0.000 claims description 92
• 125000003729 nucleotide group Chemical group 0.000 claims description 92
• 102000039446 nucleic acids Human genes 0.000 claims description 78
• 108020004707 nucleic acids Proteins 0.000 claims description 78
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 51
• 238000000034 method Methods 0.000 claims description 48
• 210000001519 tissue Anatomy 0.000 claims description 48
• 208000035475 disorder Diseases 0.000 claims description 46
• 230000002062 proliferating effect Effects 0.000 claims description 46
• 241000714177 Murine leukemia virus Species 0.000 claims description 44
• 230000003612 virological effect Effects 0.000 claims description 40
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 38
• 229920001184 polypeptide Polymers 0.000 claims description 35
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 35
• 206010028980 Neoplasm Diseases 0.000 claims description 32
• 208000015181 infectious disease Diseases 0.000 claims description 32
• 238000011282 treatment Methods 0.000 claims description 31
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 29
• 102000004127 Cytokines Human genes 0.000 claims description 25
• 108090000695 Cytokines Proteins 0.000 claims description 25
• 201000011510 cancer Diseases 0.000 claims description 22
• XQCZBXHVTFVIFE-UHFFFAOYSA-N 2-amino-4-hydroxypyrimidine Chemical compound NC1=NC=CC(O)=N1 XQCZBXHVTFVIFE-UHFFFAOYSA-N 0.000 claims description 20
• 238000000576 coating method Methods 0.000 claims description 20
• 238000010839 reverse transcription Methods 0.000 claims description 20
• 241000713813 Gibbon ape leukemia virus Species 0.000 claims description 19
• 230000000694 effects Effects 0.000 claims description 19
• 108020004459 Small interfering RNA Proteins 0.000 claims description 18
• 230000003362 replicative effect Effects 0.000 claims description 16
• 239000000969 carrier Substances 0.000 claims description 15
• 230000035897 transcription Effects 0.000 claims description 14
• 238000013518 transcription Methods 0.000 claims description 14
• XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical compound NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 claims description 13
• 206010006187 Breast cancer Diseases 0.000 claims description 12
• 208000026310 Breast neoplasm Diseases 0.000 claims description 12
• 241000713869 Moloney murine leukemia virus Species 0.000 claims description 12
• 206010060862 Prostate cancer Diseases 0.000 claims description 12
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 12
• 102000006601 Thymidine Kinase Human genes 0.000 claims description 12
• 108020004440 Thymidine kinase Proteins 0.000 claims description 12
• 230000002766 immunoenhancing effect Effects 0.000 claims description 12
• 210000004962 mammalian cell Anatomy 0.000 claims description 12
• 229940002612 prodrug Drugs 0.000 claims description 12
• 239000000651 prodrug Substances 0.000 claims description 12
• 108020004705 Codon Proteins 0.000 claims description 11
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 11
• 241000712909 Reticuloendotheliosis virus Species 0.000 claims description 11
• 208000005718 Stomach Neoplasms Diseases 0.000 claims description 11
• 230000001276 controlling effect Effects 0.000 claims description 11
• 201000010536 head and neck cancer Diseases 0.000 claims description 11
• 208000014829 head and neck neoplasm Diseases 0.000 claims description 11
• 230000000977 initiatory effect Effects 0.000 claims description 11
• 230000010354 integration Effects 0.000 claims description 11
• 201000005202 lung cancer Diseases 0.000 claims description 11
• 208000020816 lung neoplasm Diseases 0.000 claims description 11
• 201000001441 melanoma Diseases 0.000 claims description 11
• 231100000252 nontoxic Toxicity 0.000 claims description 11
• 230000003000 nontoxic effect Effects 0.000 claims description 11
• 201000000498 stomach carcinoma Diseases 0.000 claims description 11
• 206010033128 Ovarian cancer Diseases 0.000 claims description 10
• 206010061535 Ovarian neoplasm Diseases 0.000 claims description 10
• 101710101148 Probable 6-oxopurine nucleoside phosphorylase Proteins 0.000 claims description 10
• 102000030764 Purine-nucleoside phosphorylase Human genes 0.000 claims description 10
• 102000018594 Tumour necrosis factor Human genes 0.000 claims description 10
• 108050007852 Tumour necrosis factor Proteins 0.000 claims description 10
• 230000004048 modification Effects 0.000 claims description 10
• 238000012986 modification Methods 0.000 claims description 10
• 210000005170 neoplastic cell Anatomy 0.000 claims description 10
• 230000001225 therapeutic effect Effects 0.000 claims description 10
• 208000003174 Brain Neoplasms Diseases 0.000 claims description 9
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 9
• 241000124008 Mammalia Species 0.000 claims description 9
• 208000006593 Urologic Neoplasms Diseases 0.000 claims description 9
• 208000021045 exocrine pancreatic carcinoma Diseases 0.000 claims description 9
• 208000005017 glioblastoma Diseases 0.000 claims description 9
• 208000012991 uterine carcinoma Diseases 0.000 claims description 9
• 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims description 8
• 201000010915 Glioblastoma multiforme Diseases 0.000 claims description 8
• 206010070863 Toxicity to various agents Diseases 0.000 claims description 8
• 230000004913 activation Effects 0.000 claims description 8
• 238000006243 chemical reaction Methods 0.000 claims description 8
• 230000002401 inhibitory effect Effects 0.000 claims description 8
• 208000032839 leukemia Diseases 0.000 claims description 8
• 238000004806 packaging method and process Methods 0.000 claims description 8
• 206010011831 Cytomegalovirus infection Diseases 0.000 claims description 7
• 241000282324 Felis Species 0.000 claims description 7
• 102100037850 Interferon gamma Human genes 0.000 claims description 7
• 108010074328 Interferon-gamma Proteins 0.000 claims description 7
• 102000000589 Interleukin-1 Human genes 0.000 claims description 7
• 108010002352 Interleukin-1 Proteins 0.000 claims description 7
• 230000012010 growth Effects 0.000 claims description 7
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 6
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 6
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 6
• 108091070501 miRNA Proteins 0.000 claims description 6
• 239000002679 microRNA Substances 0.000 claims description 6
• 208000023275 Autoimmune disease Diseases 0.000 claims description 5
• 241000282326 Felis catus Species 0.000 claims description 5
• 108010050904 Interferons Proteins 0.000 claims description 5
• 102000014150 Interferons Human genes 0.000 claims description 5
• 241000283973 Oryctolagus cuniculus Species 0.000 claims description 5
• 241001504519 Papio ursinus Species 0.000 claims description 5
• 241000881705 Porcine endogenous retrovirus Species 0.000 claims description 5
• 108091030071 RNAI Proteins 0.000 claims description 5
• 241000713820 Squirrel monkey retrovirus Species 0.000 claims description 5
• 241000101098 Xenotropic MuLV-related virus Species 0.000 claims description 5
• 230000002596 correlated effect Effects 0.000 claims description 5
• 230000009368 gene silencing by RNA Effects 0.000 claims description 5
• 229940079322 interferon Drugs 0.000 claims description 5
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 5
• 230000008771 sex reversal Effects 0.000 claims description 5
• 102100033073 Polypyrimidine tract-binding protein 1 Human genes 0.000 claims description 4
• 239000003098 androgen Substances 0.000 claims description 4
• 230000000259 anti-tumor effect Effects 0.000 claims description 3
• 241001485018 Baboon endogenous virus Species 0.000 claims description 2
• 101001135344 Homo sapiens Polypyrimidine tract-binding protein 1 Proteins 0.000 claims description 2
• 230000001177 retroviral effect Effects 0.000 abstract description 77
• 238000001415 gene therapy Methods 0.000 abstract description 6
• 238000001476 gene delivery Methods 0.000 abstract description 5
• 102000004169 proteins and genes Human genes 0.000 description 65
• 239000002245 particle Substances 0.000 description 46
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 39
• 235000018102 proteins Nutrition 0.000 description 39
• 238000005457 optimization Methods 0.000 description 38
• 108700011259 MicroRNAs Proteins 0.000 description 33
• 108020004414 DNA Proteins 0.000 description 25
• 239000003795 chemical substances by application Substances 0.000 description 16
• 102000004190 Enzymes Human genes 0.000 description 15
• 108090000790 Enzymes Proteins 0.000 description 15
• 239000011248 coating agent Substances 0.000 description 15
• 229940088598 enzyme Drugs 0.000 description 15
• -1 rev Proteins 0.000 description 15
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 14
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 14
• 229940022353 herceptin Drugs 0.000 description 14
• 108020004999 messenger RNA Proteins 0.000 description 14
• 230000014616 translation Effects 0.000 description 14
• 102000003886 Glycoproteins Human genes 0.000 description 13
• 108090000288 Glycoproteins Proteins 0.000 description 13
• 239000000427 antigen Substances 0.000 description 12
• 108091007433 antigens Proteins 0.000 description 12
• 102000036639 antigens Human genes 0.000 description 12
• 230000008859 change Effects 0.000 description 12
• 108700004025 env Genes Proteins 0.000 description 12
• 101150030339 env gene Proteins 0.000 description 12
• 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 11
• 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 11
• 102100034349 Integrase Human genes 0.000 description 11
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 11
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 11
• 231100000590 oncogenic Toxicity 0.000 description 11
• 230000002246 oncogenic effect Effects 0.000 description 11
• 239000013612 plasmid Substances 0.000 description 11
• 230000003327 cancerostatic effect Effects 0.000 description 10
• 230000001105 regulatory effect Effects 0.000 description 10
• 230000002103 transcriptional effect Effects 0.000 description 10
• 238000013519 translation Methods 0.000 description 10
• 239000003814 drug Substances 0.000 description 9
• 230000002068 genetic effect Effects 0.000 description 9
• 238000011144 upstream manufacturing Methods 0.000 description 9
• 241000710188 Encephalomyocarditis virus Species 0.000 description 8
• 101710091045 Envelope protein Proteins 0.000 description 8
• 102100034353 Integrase Human genes 0.000 description 8
• 101710188315 Protein X Proteins 0.000 description 8
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 8
• 241000714474 Rous sarcoma virus Species 0.000 description 8
• 108700009124 Transcription Initiation Site Proteins 0.000 description 8
• 241000711975 Vesicular stomatitis virus Species 0.000 description 8
• 108020000999 Viral RNA Proteins 0.000 description 8
• 108010078428 env Gene Products Proteins 0.000 description 8
• 239000000203 mixture Substances 0.000 description 8
• 102000014160 PTEN Phosphohydrolase Human genes 0.000 description 7
• 108010011536 PTEN Phosphohydrolase Proteins 0.000 description 7
• 230000000973 chemotherapeutic effect Effects 0.000 description 7
• 230000006870 function Effects 0.000 description 7
• 238000000338 in vitro Methods 0.000 description 7
• 230000002458 infectious effect Effects 0.000 description 7
• 108091070946 miR-128 stem-loop Proteins 0.000 description 7
• 102000005962 receptors Human genes 0.000 description 7
• 108020003175 receptors Proteins 0.000 description 7
• 229960004641 rituximab Drugs 0.000 description 7
• 210000000130 stem cell Anatomy 0.000 description 7
• 230000009385 viral infection Effects 0.000 description 7
• 241000725303 Human immunodeficiency virus Species 0.000 description 6
• 108091027967 Small hairpin RNA Proteins 0.000 description 6
• 230000000692 anti-sense effect Effects 0.000 description 6
• 239000013604 expression vector Substances 0.000 description 6
• 230000006872 improvement Effects 0.000 description 6
• 238000003752 polymerase chain reaction Methods 0.000 description 6
• 230000008569 process Effects 0.000 description 6
• 230000000644 propagated effect Effects 0.000 description 6
• 239000000523 sample Substances 0.000 description 6
• 102000053642 Catalytic RNA Human genes 0.000 description 5
• 108090000994 Catalytic RNA Proteins 0.000 description 5
• 108700028146 Genetic Enhancer Elements Proteins 0.000 description 5
• 241000713772 Human immunodeficiency virus 1 Species 0.000 description 5
• 108091023040 Transcription factor Proteins 0.000 description 5
• 108700019146 Transgenes Proteins 0.000 description 5
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 5
• 102100039037 Vascular endothelial growth factor A Human genes 0.000 description 5
• OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine group Chemical group [C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=NC=2C(N)=NC=NC12 OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 5
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 5
• 230000007547 defect Effects 0.000 description 5
• 201000010099 disease Diseases 0.000 description 5
• 239000006185 dispersion Substances 0.000 description 5
• 230000001965 increasing effect Effects 0.000 description 5
• 238000003780 insertion Methods 0.000 description 5
• 230000037431 insertion Effects 0.000 description 5
• 230000001404 mediated effect Effects 0.000 description 5
• 238000006384 oligomerization reaction Methods 0.000 description 5
• 108091092562 ribozyme Proteins 0.000 description 5
• 239000004055 small Interfering RNA Substances 0.000 description 5
• 239000003981 vehicle Substances 0.000 description 5
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 4
• 108010080611 Cytosine Deaminase Proteins 0.000 description 4
• 108090000542 Lymphotoxin-alpha Proteins 0.000 description 4
• 102000018697 Membrane Proteins Human genes 0.000 description 4
• 108010052285 Membrane Proteins Proteins 0.000 description 4
• 238000012408 PCR amplification Methods 0.000 description 4
• 238000011529 RT qPCR Methods 0.000 description 4
• 241000713311 Simian immunodeficiency virus Species 0.000 description 4
• 102000040945 Transcription factor Human genes 0.000 description 4
• 108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 description 4
• 102100038234 Vascular endothelial growth factor D Human genes 0.000 description 4
• 230000003321 amplification Effects 0.000 description 4
• 210000000170 cell membrane Anatomy 0.000 description 4
• 230000008034 disappearance Effects 0.000 description 4
• 239000012634 fragment Substances 0.000 description 4
• 239000005556 hormone Substances 0.000 description 4
• 229940088597 hormone Drugs 0.000 description 4
• 239000003446 ligand Substances 0.000 description 4
• 238000003199 nucleic acid amplification method Methods 0.000 description 4
• 230000002018 overexpression Effects 0.000 description 4
• PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 4
• 239000002644 phorbol ester Substances 0.000 description 4
• 239000002243 precursor Substances 0.000 description 4
• 239000000047 product Substances 0.000 description 4
• 210000002307 prostate Anatomy 0.000 description 4
• 241000894007 species Species 0.000 description 4
• 230000006641 stabilisation Effects 0.000 description 4
• 239000006228 supernatant Substances 0.000 description 4
• 230000008093 supporting effect Effects 0.000 description 4
• 238000002560 therapeutic procedure Methods 0.000 description 4
• 102100032937 CD40 ligand Human genes 0.000 description 3
• 102100027668 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Human genes 0.000 description 3
• 101710134395 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Proteins 0.000 description 3
• 206010009944 Colon cancer Diseases 0.000 description 3
• 208000001333 Colorectal Neoplasms Diseases 0.000 description 3
• 102000000311 Cytosine Deaminase Human genes 0.000 description 3
• 108010078851 HIV Reverse Transcriptase Proteins 0.000 description 3
• 206010020880 Hypertrophy Diseases 0.000 description 3
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 3
• 102100020880 Kit ligand Human genes 0.000 description 3
• 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 3
• 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 3
• 101100058550 Mus musculus Bmi1 gene Proteins 0.000 description 3
• 108091034117 Oligonucleotide Proteins 0.000 description 3
• CWHJIJJSDGEHNS-MYLFLSLOSA-N Senegenin Chemical compound C1[C@H](O)[C@H](O)[C@@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)C(CC[C@]4(CCC(C[C@H]44)(C)C)C(O)=O)=C4[C@@H](CCl)C[C@@H]3[C@]21C CWHJIJJSDGEHNS-MYLFLSLOSA-N 0.000 description 3
• 102000013275 Somatomedins Human genes 0.000 description 3
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 3
• 108010003533 Viral Envelope Proteins Proteins 0.000 description 3
• 230000015572 biosynthetic process Effects 0.000 description 3
• 210000004556 brain Anatomy 0.000 description 3
• 208000035269 cancer or benign tumor Diseases 0.000 description 3
• 210000000234 capsid Anatomy 0.000 description 3
• 230000001413 cellular effect Effects 0.000 description 3
• 210000003169 central nervous system Anatomy 0.000 description 3
• 201000010989 colorectal carcinoma Diseases 0.000 description 3
• 230000000295 complement effect Effects 0.000 description 3
• 239000002131 composite material Substances 0.000 description 3
• 238000001514 detection method Methods 0.000 description 3
• 238000000684 flow cytometry Methods 0.000 description 3
• 108700004026 gag Genes Proteins 0.000 description 3
• 238000001727 in vivo Methods 0.000 description 3
• 230000005764 inhibitory process Effects 0.000 description 3
• 230000003993 interaction Effects 0.000 description 3
• 238000007834 ligase chain reaction Methods 0.000 description 3
• 230000000670 limiting effect Effects 0.000 description 3
• 210000001165 lymph node Anatomy 0.000 description 3
• 239000000463 material Substances 0.000 description 3
• PUPNJSIFIXXJCH-UHFFFAOYSA-N n-(4-hydroxyphenyl)-2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetamide Chemical compound C1=CC(O)=CC=C1NC(=O)CN1S(=O)(=O)C2=CC=CC=C2C1=O PUPNJSIFIXXJCH-UHFFFAOYSA-N 0.000 description 3
• 230000008520 organization Effects 0.000 description 3
• 108700004029 pol Genes Proteins 0.000 description 3
• 230000008488 polyadenylation Effects 0.000 description 3
• 230000001737 promoting effect Effects 0.000 description 3
• 238000010561 standard procedure Methods 0.000 description 3
• 239000009871 tenuigenin Substances 0.000 description 3
• 229940124597 therapeutic agent Drugs 0.000 description 3
• 238000010361 transduction Methods 0.000 description 3
• 230000026683 transduction Effects 0.000 description 3
• 238000001890 transfection Methods 0.000 description 3
• 230000009261 transgenic effect Effects 0.000 description 3
• 229960000575 trastuzumab Drugs 0.000 description 3
• 210000004881 tumor cell Anatomy 0.000 description 3
• 238000001262 western blot Methods 0.000 description 3
• XXJWYDDUDKYVKI-UHFFFAOYSA-N 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline Chemical compound COC1=CC2=C(OC=3C(=C4C=C(C)NC4=CC=3)F)N=CN=C2C=C1OCCCN1CCCC1 XXJWYDDUDKYVKI-UHFFFAOYSA-N 0.000 description 2
• 241000713826 Avian leukosis virus Species 0.000 description 2
• 241000714266 Bovine leukemia virus Species 0.000 description 2
• 108010029697 CD40 Ligand Proteins 0.000 description 2
• 102100025221 CD70 antigen Human genes 0.000 description 2
• 206010008190 Cerebrovascular accident Diseases 0.000 description 2
• 108091026890 Coding region Proteins 0.000 description 2
• 241000724252 Cucumber mosaic virus Species 0.000 description 2
• 102000053602 DNA Human genes 0.000 description 2
• 230000006820 DNA synthesis Effects 0.000 description 2
• 108010074604 Epoetin Alfa Proteins 0.000 description 2
• 208000000461 Esophageal Neoplasms Diseases 0.000 description 2
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
• 108010029961 Filgrastim Proteins 0.000 description 2
• 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 2
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 2
• 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 2
• 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 2
• 208000031886 HIV Infections Diseases 0.000 description 2
• 102000014702 Haptoglobin Human genes 0.000 description 2
• 108050005077 Haptoglobin Proteins 0.000 description 2
• 241000713858 Harvey murine sarcoma virus Species 0.000 description 2
• 101710154606 Hemagglutinin Proteins 0.000 description 2
• 206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 description 2
• 241000714260 Human T-lymphotropic virus 1 Species 0.000 description 2
• 241000714259 Human T-lymphotropic virus 2 Species 0.000 description 2
• 241000713340 Human immunodeficiency virus 2 Species 0.000 description 2
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
• XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 2
• 108060003951 Immunoglobulin Proteins 0.000 description 2
• 108010002350 Interleukin-2 Proteins 0.000 description 2
• 102000000588 Interleukin-2 Human genes 0.000 description 2
• 102000000646 Interleukin-3 Human genes 0.000 description 2
• 108010002386 Interleukin-3 Proteins 0.000 description 2
• 108090001005 Interleukin-6 Proteins 0.000 description 2
• 102000004889 Interleukin-6 Human genes 0.000 description 2
• 108090001007 Interleukin-8 Proteins 0.000 description 2
• 102000004890 Interleukin-8 Human genes 0.000 description 2
• 239000002147 L01XE04 - Sunitinib Substances 0.000 description 2
• 239000003798 L01XE11 - Pazopanib Substances 0.000 description 2
• 102000007330 LDL Lipoproteins Human genes 0.000 description 2
• 108010007622 LDL Lipoproteins Proteins 0.000 description 2
• 206010061523 Lip and/or oral cavity cancer Diseases 0.000 description 2
• 206010025323 Lymphomas Diseases 0.000 description 2
• 102000004083 Lymphotoxin-alpha Human genes 0.000 description 2
• 102100026238 Lymphotoxin-alpha Human genes 0.000 description 2
• 241000713821 Mason-Pfizer monkey virus Species 0.000 description 2
• 108010057466 NF-kappa B Proteins 0.000 description 2
• 102000003945 NF-kappa B Human genes 0.000 description 2
• 108010025020 Nerve Growth Factor Proteins 0.000 description 2
• 102000015336 Nerve Growth Factor Human genes 0.000 description 2
• 102100037214 Orotidine 5'-phosphate decarboxylase Human genes 0.000 description 2
• 108010055012 Orotidine-5'-phosphate decarboxylase Proteins 0.000 description 2
• 101710093908 Outer capsid protein VP4 Proteins 0.000 description 2
• 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 2
• 102000035195 Peptidases Human genes 0.000 description 2
• 108091005804 Peptidases Proteins 0.000 description 2
• 102100035194 Placenta growth factor Human genes 0.000 description 2
• 101710176177 Protein A56 Proteins 0.000 description 2
• 108010019674 Proto-Oncogene Proteins c-sis Proteins 0.000 description 2
• 108020005067 RNA Splice Sites Proteins 0.000 description 2
• 241000700159 Rattus Species 0.000 description 2
• 241000712907 Retroviridae Species 0.000 description 2
• 206010039509 Scab Diseases 0.000 description 2
• 108010039445 Stem Cell Factor Proteins 0.000 description 2
• 208000006011 Stroke Diseases 0.000 description 2
• 208000000389 T-cell leukemia Diseases 0.000 description 2
• 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 description 2
• GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
• 102100023132 Transcription factor Jun Human genes 0.000 description 2
• 102100032100 Tumor necrosis factor ligand superfamily member 8 Human genes 0.000 description 2
• 108010073925 Vascular Endothelial Growth Factor B Proteins 0.000 description 2
• 102100038217 Vascular endothelial growth factor B Human genes 0.000 description 2
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 2
• 241000713325 Visna/maedi virus Species 0.000 description 2
• 230000003213 activating effect Effects 0.000 description 2
• SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
• 230000000735 allogeneic effect Effects 0.000 description 2
• 238000004458 analytical method Methods 0.000 description 2
• 239000002870 angiogenesis inducing agent Substances 0.000 description 2
• 239000003242 anti bacterial agent Substances 0.000 description 2
• 229940088710 antibiotic agent Drugs 0.000 description 2
• 239000002246 antineoplastic agent Substances 0.000 description 2
• NOFOAYPPHIUXJR-APNQCZIXSA-N aphidicolin Chemical compound C1[C@@]23[C@@]4(C)CC[C@@H](O)[C@@](C)(CO)[C@@H]4CC[C@H]3C[C@H]1[C@](CO)(O)CC2 NOFOAYPPHIUXJR-APNQCZIXSA-N 0.000 description 2
• SEKZNWAQALMJNH-YZUCACDQSA-N aphidicolin Natural products C[C@]1(CO)CC[C@]23C[C@H]1C[C@@H]2CC[C@H]4[C@](C)(CO)[C@H](O)CC[C@]34C SEKZNWAQALMJNH-YZUCACDQSA-N 0.000 description 2
• 238000013459 approach Methods 0.000 description 2
• 239000012752 auxiliary agent Substances 0.000 description 2
• 230000033228 biological regulation Effects 0.000 description 2
• 230000000903 blocking effect Effects 0.000 description 2
• 230000000711 cancerogenic effect Effects 0.000 description 2
• 231100000315 carcinogenic Toxicity 0.000 description 2
• 229960002412 cediranib Drugs 0.000 description 2
• 230000022131 cell cycle Effects 0.000 description 2
• 230000003915 cell function Effects 0.000 description 2
• 230000010261 cell growth Effects 0.000 description 2
• 238000010367 cloning Methods 0.000 description 2
• 239000012141 concentrate Substances 0.000 description 2
• 239000007859 condensation product Substances 0.000 description 2
• 231100000433 cytotoxic Toxicity 0.000 description 2
• 239000002254 cytotoxic agent Substances 0.000 description 2
• 229940127089 cytotoxic agent Drugs 0.000 description 2
• 231100000599 cytotoxic agent Toxicity 0.000 description 2
• 230000001472 cytotoxic effect Effects 0.000 description 2
• 230000007423 decrease Effects 0.000 description 2
• 238000011161 development Methods 0.000 description 2
• 230000018109 developmental process Effects 0.000 description 2
• 230000029087 digestion Effects 0.000 description 2
• 229940079593 drug Drugs 0.000 description 2
• 108010030074 endodeoxyribonuclease MluI Proteins 0.000 description 2
• 230000002255 enzymatic effect Effects 0.000 description 2
• 229960003388 epoetin alfa Drugs 0.000 description 2
• 201000004101 esophageal cancer Diseases 0.000 description 2
• 230000002349 favourable effect Effects 0.000 description 2
• 229960004177 filgrastim Drugs 0.000 description 2
• 238000006062 fragmentation reaction Methods 0.000 description 2
• 230000004927 fusion Effects 0.000 description 2
• 101150098622 gag gene Proteins 0.000 description 2
• 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 2
• 239000000185 hemagglutinin Substances 0.000 description 2
• 238000003119 immunoblot Methods 0.000 description 2
• 102000018358 immunoglobulin Human genes 0.000 description 2
• 229960001438 immunostimulant agent Drugs 0.000 description 2
• 239000003022 immunostimulating agent Substances 0.000 description 2
• 230000003308 immunostimulating effect Effects 0.000 description 2
• 230000001976 improved effect Effects 0.000 description 2
• 230000006698 induction Effects 0.000 description 2
• 238000002955 isolation Methods 0.000 description 2
• 210000002510 keratinocyte Anatomy 0.000 description 2
• 108091023663 let-7 stem-loop Proteins 0.000 description 2
• 108091063478 let-7-1 stem-loop Proteins 0.000 description 2
• 108091049777 let-7-2 stem-loop Proteins 0.000 description 2
• 210000005229 liver cell Anatomy 0.000 description 2
• 238000005259 measurement Methods 0.000 description 2
• 230000007246 mechanism Effects 0.000 description 2
• 239000012528 membrane Substances 0.000 description 2
• 108091059786 miR-128-1 stem-loop Proteins 0.000 description 2
• 108091084874 miR-128-2 stem-loop Proteins 0.000 description 2
• 108091079658 miR-142-1 stem-loop Proteins 0.000 description 2
• 108091071830 miR-142-2 stem-loop Proteins 0.000 description 2
• 230000000394 mitotic effect Effects 0.000 description 2
• 238000002715 modification method Methods 0.000 description 2
• 229940053128 nerve growth factor Drugs 0.000 description 2
• 210000002569 neuron Anatomy 0.000 description 2
• 108091027963 non-coding RNA Proteins 0.000 description 2
• 102000042567 non-coding RNA Human genes 0.000 description 2
• 210000001331 nose Anatomy 0.000 description 2
• 229960000639 pazopanib Drugs 0.000 description 2
• CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 description 2
• 239000000813 peptide hormone Substances 0.000 description 2
• 239000008194 pharmaceutical composition Substances 0.000 description 2
• 108010017843 platelet-derived growth factor A Proteins 0.000 description 2
• 101150088264 pol gene Proteins 0.000 description 2
• 108010063723 poly-pyrimidine tract binding protein Proteins 0.000 description 2
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 2
• 230000001566 pro-viral effect Effects 0.000 description 2
• 230000005855 radiation Effects 0.000 description 2
• 230000002829 reductive effect Effects 0.000 description 2
• 238000011160 research Methods 0.000 description 2
• 230000004044 response Effects 0.000 description 2
• 229930002330 retinoic acid Natural products 0.000 description 2
• 230000002441 reversible effect Effects 0.000 description 2
• 108010038379 sargramostim Proteins 0.000 description 2
• 229960002530 sargramostim Drugs 0.000 description 2
• 210000002966 serum Anatomy 0.000 description 2
• 210000004927 skin cell Anatomy 0.000 description 2
• 230000008685 targeting Effects 0.000 description 2
• 238000012360 testing method Methods 0.000 description 2
• CXVCSRUYMINUSF-UHFFFAOYSA-N tetrathiomolybdate(2-) Chemical compound [S-][Mo]([S-])(=S)=S CXVCSRUYMINUSF-UHFFFAOYSA-N 0.000 description 2
• 231100000331 toxic Toxicity 0.000 description 2
• 230000002588 toxic effect Effects 0.000 description 2
• 238000012546 transfer Methods 0.000 description 2
• 238000003146 transient transfection Methods 0.000 description 2
• 241000701161 unidentified adenovirus Species 0.000 description 2
• 229960000241 vandetanib Drugs 0.000 description 2
• UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 description 2
• 229950000578 vatalanib Drugs 0.000 description 2
• YCOYDOIWSSHVCK-UHFFFAOYSA-N vatalanib Chemical compound C1=CC(Cl)=CC=C1NC(C1=CC=CC=C11)=NN=C1CC1=CC=NC=C1 YCOYDOIWSSHVCK-UHFFFAOYSA-N 0.000 description 2
• 230000005570 vertical transmission Effects 0.000 description 2
• 230000029812 viral genome replication Effects 0.000 description 2
• DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
• SRSHBZRURUNOSM-DEOSSOPVSA-N (4-chlorophenyl) (1s)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate Chemical compound C1=CC(OC)=CC=C1[C@H]1C(NC=2C3=CC(Cl)=CC=2)=C3CCN1C(=O)OC1=CC=C(Cl)C=C1 SRSHBZRURUNOSM-DEOSSOPVSA-N 0.000 description 1
• NWXMGUDVXFXRIG-WESIUVDSSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O NWXMGUDVXFXRIG-WESIUVDSSA-N 0.000 description 1
• HXSHBEIVXXJJIJ-MHEUWTTISA-N (8R,9S,13S,14S)-15-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@]4(C)C(O)CC(OC)[C@H]4[C@@H]3CCC2=C1 HXSHBEIVXXJJIJ-MHEUWTTISA-N 0.000 description 1
• YQJWOUQGXATDAE-ACNBBOPNSA-N (8s,9s,13r,14s)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthrene-3-carboxamide Chemical compound C([C@@H]12)C[C@]3(C)C=CC[C@H]3[C@@H]1CCC1=C2C=C(OC)C(C(N)=O)=C1 YQJWOUQGXATDAE-ACNBBOPNSA-N 0.000 description 1
• 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
• BUAJNGPDPGKBGV-UHFFFAOYSA-N 1-(1-phenylcyclohexyl)piperidin-1-ium;chloride Chemical compound [Cl-].C1CCCC[NH+]1C1(C=2C=CC=CC=2)CCCCC1 BUAJNGPDPGKBGV-UHFFFAOYSA-N 0.000 description 1
• YABJJWZLRMPFSI-UHFFFAOYSA-N 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine Chemical compound N=1C2=CC(OC=3C=C(N=CC=3)C=3NC(=CN=3)C(F)(F)F)=CC=C2N(C)C=1NC1=CC=C(C(F)(F)F)C=C1 YABJJWZLRMPFSI-UHFFFAOYSA-N 0.000 description 1
• GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 1
• FGTCROZDHDSNIO-UHFFFAOYSA-N 3-(4-quinolinylmethylamino)-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide Chemical compound C1=CC(OC(F)(F)F)=CC=C1NC(=O)C1=C(NCC=2C3=CC=CC=C3N=CC=2)C=CS1 FGTCROZDHDSNIO-UHFFFAOYSA-N 0.000 description 1
• HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
• 102000002627 4-1BB Ligand Human genes 0.000 description 1
• 108010082808 4-1BB Ligand Proteins 0.000 description 1
• AKJHMTWEGVYYSE-AIRMAKDCSA-N 4-HPR Chemical compound C=1C=C(O)C=CC=1NC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C AKJHMTWEGVYYSE-AIRMAKDCSA-N 0.000 description 1
• QFCXANHHBCGMAS-UHFFFAOYSA-N 4-[[4-(4-chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(COC=2C=3OC=CC=3C(NC=3C=CC(Cl)=CC=3)=NN=2)=C1 QFCXANHHBCGMAS-UHFFFAOYSA-N 0.000 description 1
• WLCZTRVUXYALDD-IBGZPJMESA-N 7-[[(2s)-2,6-bis(2-methoxyethoxycarbonylamino)hexanoyl]amino]heptoxy-methylphosphinic acid Chemical compound COCCOC(=O)NCCCC[C@H](NC(=O)OCCOC)C(=O)NCCCCCCCOP(C)(O)=O WLCZTRVUXYALDD-IBGZPJMESA-N 0.000 description 1
• OONFNUWBHFSNBT-HXUWFJFHSA-N AEE788 Chemical compound C1CN(CC)CCN1CC1=CC=C(C=2NC3=NC=NC(N[C@H](C)C=4C=CC=CC=4)=C3C=2)C=C1 OONFNUWBHFSNBT-HXUWFJFHSA-N 0.000 description 1
• 101150107820 ATG9 gene Proteins 0.000 description 1
• 102000013563 Acid Phosphatase Human genes 0.000 description 1
• 108010051457 Acid Phosphatase Proteins 0.000 description 1
• 208000002874 Acne Vulgaris Diseases 0.000 description 1
• 102100033312 Alpha-2-macroglobulin Human genes 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 241000710929 Alphavirus Species 0.000 description 1
• 102100022987 Angiogenin Human genes 0.000 description 1
• 102000004881 Angiotensinogen Human genes 0.000 description 1
• 108090001067 Angiotensinogen Proteins 0.000 description 1
• 101100272049 Arabidopsis thaliana AUG8 gene Proteins 0.000 description 1
• 102000003916 Arrestin Human genes 0.000 description 1
• 108090000328 Arrestin Proteins 0.000 description 1
• 241000271566 Aves Species 0.000 description 1
• 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 description 1
• MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 description 1
• 101100057216 Bos taurus ATG9A gene Proteins 0.000 description 1
• 108010074051 C-Reactive Protein Proteins 0.000 description 1
• 102100032752 C-reactive protein Human genes 0.000 description 1
• 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
• 102100034808 CCAAT/enhancer-binding protein alpha Human genes 0.000 description 1
• 101710168309 CCAAT/enhancer-binding protein alpha Proteins 0.000 description 1
• 101150028326 CD gene Proteins 0.000 description 1
• 108010046080 CD27 Ligand Proteins 0.000 description 1
• 102100027207 CD27 antigen Human genes 0.000 description 1
• 101150013553 CD40 gene Proteins 0.000 description 1
• 108010001282 CT-322 Proteins 0.000 description 1
• 101710134389 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 Proteins 0.000 description 1
• 201000009030 Carcinoma Diseases 0.000 description 1
• 241000701489 Cauliflower mosaic virus Species 0.000 description 1
• 206010008342 Cervix carcinoma Diseases 0.000 description 1
• 108090000317 Chymotrypsin Proteins 0.000 description 1
• 108060005980 Collagenase Proteins 0.000 description 1
• 102000029816 Collagenase Human genes 0.000 description 1
• 108010028780 Complement C3 Proteins 0.000 description 1
• 102000016918 Complement C3 Human genes 0.000 description 1
• 108091029523 CpG island Proteins 0.000 description 1
• 241000701022 Cytomegalovirus Species 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
• 108091026908 Downstream promoter element Proteins 0.000 description 1
• 101100044298 Drosophila melanogaster fand gene Proteins 0.000 description 1
• 102000001301 EGF receptor Human genes 0.000 description 1
• 108060006698 EGF receptor Proteins 0.000 description 1
• 108010014258 Elastin Proteins 0.000 description 1
• 102000016942 Elastin Human genes 0.000 description 1
• 108700041152 Endoplasmic Reticulum Chaperone BiP Proteins 0.000 description 1
• 102100021451 Endoplasmic reticulum chaperone BiP Human genes 0.000 description 1
• 241000991587 Enterovirus C Species 0.000 description 1
• 101710121417 Envelope glycoprotein Proteins 0.000 description 1
• 102000003951 Erythropoietin Human genes 0.000 description 1
• 108090000394 Erythropoietin Proteins 0.000 description 1
• 102100031939 Erythropoietin Human genes 0.000 description 1
• 241000206602 Eukaryota Species 0.000 description 1
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
• 101150064015 FAS gene Proteins 0.000 description 1
• 102000015212 Fas Ligand Protein Human genes 0.000 description 1
• 108010039471 Fas Ligand Protein Proteins 0.000 description 1
• 108010049003 Fibrinogen Proteins 0.000 description 1
• 102000008946 Fibrinogen Human genes 0.000 description 1
• 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
• 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
• 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 description 1
• 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 description 1
• 102100028412 Fibroblast growth factor 10 Human genes 0.000 description 1
• 108090001047 Fibroblast growth factor 10 Proteins 0.000 description 1
• 108050003237 Fibroblast growth factor 11 Proteins 0.000 description 1
• 102100028413 Fibroblast growth factor 11 Human genes 0.000 description 1
• 108050003239 Fibroblast growth factor 12 Proteins 0.000 description 1
• 102100028417 Fibroblast growth factor 12 Human genes 0.000 description 1
• 108090000046 Fibroblast growth factor 14 Proteins 0.000 description 1
• 102000003685 Fibroblast growth factor 14 Human genes 0.000 description 1
• 102100035308 Fibroblast growth factor 17 Human genes 0.000 description 1
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 1
• 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 1
• 108090000378 Fibroblast growth factor 3 Proteins 0.000 description 1
• 102100028043 Fibroblast growth factor 3 Human genes 0.000 description 1
• 102100028072 Fibroblast growth factor 4 Human genes 0.000 description 1
• 108090000381 Fibroblast growth factor 4 Proteins 0.000 description 1
• 108090000380 Fibroblast growth factor 5 Proteins 0.000 description 1
• 102100028073 Fibroblast growth factor 5 Human genes 0.000 description 1
• 108090000382 Fibroblast growth factor 6 Proteins 0.000 description 1
• 102100028075 Fibroblast growth factor 6 Human genes 0.000 description 1
• 102100028071 Fibroblast growth factor 7 Human genes 0.000 description 1
• 108090000385 Fibroblast growth factor 7 Proteins 0.000 description 1
• 108090000368 Fibroblast growth factor 8 Proteins 0.000 description 1
• 102100037680 Fibroblast growth factor 8 Human genes 0.000 description 1
• 102100037665 Fibroblast growth factor 9 Human genes 0.000 description 1
• 108090000367 Fibroblast growth factor 9 Proteins 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 102100033840 General transcription factor IIF subunit 1 Human genes 0.000 description 1
• 102100032863 General transcription factor IIH subunit 3 Human genes 0.000 description 1
• 101710103262 Glandular kallikrein Proteins 0.000 description 1
• 208000032612 Glial tumor Diseases 0.000 description 1
• 206010018338 Glioma Diseases 0.000 description 1
• 229930186217 Glycolipid Natural products 0.000 description 1
• 108010051696 Growth Hormone Proteins 0.000 description 1
• 101150112743 HSPA5 gene Proteins 0.000 description 1
• 241000238631 Hexapoda Species 0.000 description 1
• 101000914511 Homo sapiens CD27 antigen Proteins 0.000 description 1
• 101000934356 Homo sapiens CD70 antigen Proteins 0.000 description 1
• 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 description 1
• 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 description 1
• 101000666405 Homo sapiens General transcription factor IIH subunit 1 Proteins 0.000 description 1
• 101000655398 Homo sapiens General transcription factor IIH subunit 2 Proteins 0.000 description 1
• 101000655391 Homo sapiens General transcription factor IIH subunit 3 Proteins 0.000 description 1
• 101000655406 Homo sapiens General transcription factor IIH subunit 4 Proteins 0.000 description 1
• 101000655402 Homo sapiens General transcription factor IIH subunit 5 Proteins 0.000 description 1
• 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 description 1
• 101001001487 Homo sapiens Phosphatidylinositol-glycan biosynthesis class F protein Proteins 0.000 description 1
• 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 description 1
• 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 description 1
• 101100207070 Homo sapiens TNFSF8 gene Proteins 0.000 description 1
• 101001050288 Homo sapiens Transcription factor Jun Proteins 0.000 description 1
• 101000597785 Homo sapiens Tumor necrosis factor receptor superfamily member 6B Proteins 0.000 description 1
• 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 description 1
• 101000807008 Homo sapiens Uracil phosphoribosyltransferase homolog Proteins 0.000 description 1
• 241000714192 Human spumaretrovirus Species 0.000 description 1
• 206010062767 Hypophysitis Diseases 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 206010061598 Immunodeficiency Diseases 0.000 description 1
• 208000029462 Immunodeficiency disease Diseases 0.000 description 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
• 101000668058 Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) RNA-directed RNA polymerase catalytic subunit Proteins 0.000 description 1
• 108010061833 Integrases Proteins 0.000 description 1
• 108091029795 Intergenic region Proteins 0.000 description 1
• 102100020881 Interleukin-1 alpha Human genes 0.000 description 1
• 102000003777 Interleukin-1 beta Human genes 0.000 description 1
• 108090000193 Interleukin-1 beta Proteins 0.000 description 1
• 102000003814 Interleukin-10 Human genes 0.000 description 1
• 108090000174 Interleukin-10 Proteins 0.000 description 1
• 108090000177 Interleukin-11 Proteins 0.000 description 1
• 102000003815 Interleukin-11 Human genes 0.000 description 1
• 108010065805 Interleukin-12 Proteins 0.000 description 1
• 102000013462 Interleukin-12 Human genes 0.000 description 1
• 108090000176 Interleukin-13 Proteins 0.000 description 1
• 102000003816 Interleukin-13 Human genes 0.000 description 1
• 102000003812 Interleukin-15 Human genes 0.000 description 1
• 108090000172 Interleukin-15 Proteins 0.000 description 1
• 102000049772 Interleukin-16 Human genes 0.000 description 1
• 101800003050 Interleukin-16 Proteins 0.000 description 1
• 102000013691 Interleukin-17 Human genes 0.000 description 1
• 108050003558 Interleukin-17 Proteins 0.000 description 1
• 102000003810 Interleukin-18 Human genes 0.000 description 1
• 108090000171 Interleukin-18 Proteins 0.000 description 1
• 102100039879 Interleukin-19 Human genes 0.000 description 1
• 108050009288 Interleukin-19 Proteins 0.000 description 1
• 108010082786 Interleukin-1alpha Proteins 0.000 description 1
• 102100030703 Interleukin-22 Human genes 0.000 description 1
• 102000004388 Interleukin-4 Human genes 0.000 description 1
• 108090000978 Interleukin-4 Proteins 0.000 description 1
• 102100039897 Interleukin-5 Human genes 0.000 description 1
• 108010002616 Interleukin-5 Proteins 0.000 description 1
• 102100021592 Interleukin-7 Human genes 0.000 description 1
• 108010002586 Interleukin-7 Proteins 0.000 description 1
• 108010002335 Interleukin-9 Proteins 0.000 description 1
• 102000000585 Interleukin-9 Human genes 0.000 description 1
• 102000011781 Karyopherins Human genes 0.000 description 1
• 108010062228 Karyopherins Proteins 0.000 description 1
• 102100035792 Kininogen-1 Human genes 0.000 description 1
• 108010077861 Kininogens Proteins 0.000 description 1
• 239000005511 L01XE05 - Sorafenib Substances 0.000 description 1
• 239000002118 L01XE12 - Vandetanib Substances 0.000 description 1
• 102000000853 LDL receptors Human genes 0.000 description 1
• 108010001831 LDL receptors Proteins 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 241000713666 Lentivirus Species 0.000 description 1
• 206010062038 Lip neoplasm Diseases 0.000 description 1
• 108010013563 Lipoprotein Lipase Proteins 0.000 description 1
• 102100022119 Lipoprotein lipase Human genes 0.000 description 1
• 102100026894 Lymphotoxin-beta Human genes 0.000 description 1
• 108090000362 Lymphotoxin-beta Proteins 0.000 description 1
• 241000701076 Macacine alphaherpesvirus 1 Species 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 102000000422 Matrix Metalloproteinase 3 Human genes 0.000 description 1
• 201000005505 Measles Diseases 0.000 description 1
• 108010090054 Membrane Glycoproteins Proteins 0.000 description 1
• 102000012750 Membrane Glycoproteins Human genes 0.000 description 1
• 206010027336 Menstruation delayed Diseases 0.000 description 1
• 102000003792 Metallothionein Human genes 0.000 description 1
• 108090000157 Metallothionein Proteins 0.000 description 1
• 241001465754 Metazoa Species 0.000 description 1
• 102000014171 Milk Proteins Human genes 0.000 description 1
• 108010011756 Milk Proteins Proteins 0.000 description 1
• 108091027966 Mir-137 Proteins 0.000 description 1
• 108091062140 Mir-223 Proteins 0.000 description 1
• 108091027559 Mir-96 microRNA Proteins 0.000 description 1
• 241000713333 Mouse mammary tumor virus Species 0.000 description 1
• 208000003445 Mouth Neoplasms Diseases 0.000 description 1
• 101000878182 Mus musculus Fibroblast growth factor 15 Proteins 0.000 description 1
• 101100207071 Mus musculus Tnfsf8 gene Proteins 0.000 description 1
• BKAYIFDRRZZKNF-VIFPVBQESA-N N-acetylcarnosine Chemical compound CC(=O)NCCC(=O)N[C@H](C(O)=O)CC1=CN=CN1 BKAYIFDRRZZKNF-VIFPVBQESA-N 0.000 description 1
• 206010028767 Nasal sinus cancer Diseases 0.000 description 1
• 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 description 1
• 206010061306 Nasopharyngeal cancer Diseases 0.000 description 1
• 102000014413 Neuregulin Human genes 0.000 description 1
• 108050003475 Neuregulin Proteins 0.000 description 1
• 102400000058 Neuregulin-1 Human genes 0.000 description 1
• 108090000556 Neuregulin-1 Proteins 0.000 description 1
• 101100271302 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) apg-7 gene Proteins 0.000 description 1
• 108091092724 Noncoding DNA Proteins 0.000 description 1
• 108090001074 Nucleocapsid Proteins Proteins 0.000 description 1
• 102000004473 OX40 Ligand Human genes 0.000 description 1
• 108010042215 OX40 Ligand Proteins 0.000 description 1
• 108010061952 Orosomucoid Proteins 0.000 description 1
• 102000012404 Orosomucoid Human genes 0.000 description 1
• 102000004067 Osteocalcin Human genes 0.000 description 1
• 108090000573 Osteocalcin Proteins 0.000 description 1
• 102000004316 Oxidoreductases Human genes 0.000 description 1
• 108090000854 Oxidoreductases Proteins 0.000 description 1
• 208000003937 Paranasal Sinus Neoplasms Diseases 0.000 description 1
• 241000709664 Picornaviridae Species 0.000 description 1
• 108010082093 Placenta Growth Factor Proteins 0.000 description 1
• 101100335198 Pneumocystis carinii fol1 gene Proteins 0.000 description 1
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
• 108010076039 Polyproteins Proteins 0.000 description 1
• 108010015078 Pregnancy-Associated alpha 2-Macroglobulins Proteins 0.000 description 1
• 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 description 1
• 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
• 102100027584 Protein c-Fos Human genes 0.000 description 1
• 108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 description 1
• 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 description 1
• 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 description 1
• 241000125945 Protoparvovirus Species 0.000 description 1
• 102000001853 Pyrimidine Phosphorylases Human genes 0.000 description 1
• 108010054917 Pyrimidine Phosphorylases Proteins 0.000 description 1
• 108010025832 RANK Ligand Proteins 0.000 description 1
• 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
• 241000702263 Reovirus sp. Species 0.000 description 1
• 108700008625 Reporter Genes Proteins 0.000 description 1
• 108091027981 Response element Proteins 0.000 description 1
• 206010038997 Retroviral infections Diseases 0.000 description 1
• 108010003581 Ribulose-bisphosphate carboxylase Proteins 0.000 description 1
• 101100111629 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) KAR2 gene Proteins 0.000 description 1
• 206010039361 Sacroiliitis Diseases 0.000 description 1
• 206010061934 Salivary gland cancer Diseases 0.000 description 1
• 206010039710 Scleroderma Diseases 0.000 description 1
• 241000837158 Senecavirus A Species 0.000 description 1
• 102000054727 Serum Amyloid A Human genes 0.000 description 1
• 101710190759 Serum amyloid A protein Proteins 0.000 description 1
• BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
• 102100038803 Somatotropin Human genes 0.000 description 1
• 241000713896 Spleen necrosis virus Species 0.000 description 1
• UIRKNQLZZXALBI-MSVGPLKSSA-N Squalamine Chemical compound C([C@@H]1C[C@H]2O)[C@@H](NCCCNCCCCN)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@H](C(C)C)OS(O)(=O)=O)[C@@]2(C)CC1 UIRKNQLZZXALBI-MSVGPLKSSA-N 0.000 description 1
• UIRKNQLZZXALBI-UHFFFAOYSA-N Squalamine Natural products OC1CC2CC(NCCCNCCCCN)CCC2(C)C2C1C1CCC(C(C)CCC(C(C)C)OS(O)(=O)=O)C1(C)CC2 UIRKNQLZZXALBI-UHFFFAOYSA-N 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 206010042566 Superinfection Diseases 0.000 description 1
• 102100036236 Synaptonemal complex protein 2 Human genes 0.000 description 1
• 108091036066 Three prime untranslated region Proteins 0.000 description 1
• 102000036693 Thrombopoietin Human genes 0.000 description 1
• 108010041111 Thrombopoietin Proteins 0.000 description 1
• 208000033781 Thyroid carcinoma Diseases 0.000 description 1
• 208000024770 Thyroid neoplasm Diseases 0.000 description 1
• 102000057032 Tissue Kallikreins Human genes 0.000 description 1
• 206010062129 Tongue neoplasm Diseases 0.000 description 1
• 101710120037 Toxin CcdB Proteins 0.000 description 1
• 101000938863 Toxoplasma gondii Uracil phosphoribosyltransferase Proteins 0.000 description 1
• 102000006290 Transcription Factor TFIID Human genes 0.000 description 1
• 108010083268 Transcription Factor TFIID Proteins 0.000 description 1
• 108090000941 Transcription factor TFIIB Proteins 0.000 description 1
• 102000004408 Transcription factor TFIIB Human genes 0.000 description 1
• 102100024568 Tumor necrosis factor ligand superfamily member 11 Human genes 0.000 description 1
• 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 1
• 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 1
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
• 102100035284 Tumor necrosis factor receptor superfamily member 6B Human genes 0.000 description 1
• 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 1
• 108020000553 UMP kinase Proteins 0.000 description 1
• 102100037717 Uracil phosphoribosyltransferase homolog Human genes 0.000 description 1
• 229910052770 Uranium Inorganic materials 0.000 description 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
• 108020005202 Viral DNA Proteins 0.000 description 1
• 108010067390 Viral Proteins Proteins 0.000 description 1
• 239000005862 Whey Substances 0.000 description 1
• 102000007544 Whey Proteins Human genes 0.000 description 1
• 108010046377 Whey Proteins Proteins 0.000 description 1
• LTEJRLHKIYCEOX-PUODRLBUSA-N [(2r)-1-[4-[(4-fluoro-2-methyl-1h-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypropan-2-yl] 2-aminopropanoate Chemical compound C1=C2NC(C)=CC2=C(F)C(OC2=NC=NN3C=C(C(=C32)C)OC[C@@H](C)OC(=O)C(C)N)=C1 LTEJRLHKIYCEOX-PUODRLBUSA-N 0.000 description 1
• 238000009825 accumulation Methods 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 206010000496 acne Diseases 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 230000000996 additive effect Effects 0.000 description 1
• 229960005305 adenosine Drugs 0.000 description 1
• 230000001919 adrenal effect Effects 0.000 description 1
• 101150099105 alien gene Proteins 0.000 description 1
• 108010050122 alpha 1-Antitrypsin Proteins 0.000 description 1
• 102000015395 alpha 1-Antitrypsin Human genes 0.000 description 1
• 229940024142 alpha 1-antitrypsin Drugs 0.000 description 1
• 102000013529 alpha-Fetoproteins Human genes 0.000 description 1
• 108010026331 alpha-Fetoproteins Proteins 0.000 description 1
• 210000002821 alveolar epithelial cell Anatomy 0.000 description 1
• 108010072788 angiogenin Proteins 0.000 description 1
• ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 description 1
• 239000010775 animal oil Substances 0.000 description 1
• 230000003527 anti-angiogenesis Effects 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 230000003078 antioxidant effect Effects 0.000 description 1
• 235000006708 antioxidants Nutrition 0.000 description 1
• 238000011225 antiretroviral therapy Methods 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 101150034124 ask gene Proteins 0.000 description 1
• 229960003005 axitinib Drugs 0.000 description 1
• RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 description 1
• 210000003719 b-lymphocyte Anatomy 0.000 description 1
• 230000001580 bacterial effect Effects 0.000 description 1
• 230000008901 benefit Effects 0.000 description 1
• 229960000397 bevacizumab Drugs 0.000 description 1
• JKXXLIACMWFHSH-FIIWBELYSA-A bevasiranib sodium Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP([O-])(=O)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]([C@@H](O[C@@H]2CO)N2C3=NC=NC(N)=C3N=C2)O)N2C(N=C(N)C=C2)=O)O)N2C(N=C(N)C=C2)=O)O)N2C(NC(=O)C=C2)=O)O)N2C(N=C(N)C=C2)=O)O)N2C3=NC=NC(N)=C3N=C2)O)N2C(N=C(N)C=C2)=O)O)N2C(N=C(N)C=C2)=O)O)N2C3=NC=NC(N)=C3N=C2)O)N2C3=NC=NC(N)=C3N=C2)O)N2C3=C(C(NC(N)=N3)=O)N=C2)O)N2C3=C(C(NC(N)=N3)=O)N=C2)O)N2C(N=C(N)C=C2)=O)O)N2C(N=C(N)C=C2)=O)O)N2C3=NC=NC(N)=C3N=C2)O)N2C3=C(C(NC(N)=N3)=O)N=C2)O)N2C(N=C(N)C=C2)=O)O)N2C3=NC=NC(N)=C3N=C2)O)N2C(N=C(N)C=C2)=O)O)[C@@H](O)C1 JKXXLIACMWFHSH-FIIWBELYSA-A 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 239000003139 biocide Substances 0.000 description 1
• 230000031018 biological processes and functions Effects 0.000 description 1
• 210000000481 breast Anatomy 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• 229910000389 calcium phosphate Inorganic materials 0.000 description 1
• 235000011010 calcium phosphates Nutrition 0.000 description 1
• 238000004113 cell culture Methods 0.000 description 1
• 230000024245 cell differentiation Effects 0.000 description 1
• 239000013592 cell lysate Substances 0.000 description 1
• 230000004663 cell proliferation Effects 0.000 description 1
• 230000009028 cell transition Effects 0.000 description 1
• 230000007541 cellular toxicity Effects 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• 201000010881 cervical cancer Diseases 0.000 description 1
• PIQCTGMSNWUMAF-UHFFFAOYSA-N chembl522892 Chemical compound C1CN(C)CCN1C1=CC=C(NC(=N2)C=3C(NC4=CC=CC(F)=C4C=3N)=O)C2=C1 PIQCTGMSNWUMAF-UHFFFAOYSA-N 0.000 description 1
• 239000003153 chemical reaction reagent Substances 0.000 description 1
• 238000002512 chemotherapy Methods 0.000 description 1
• 210000001612 chondrocyte Anatomy 0.000 description 1
• 229960002376 chymotrypsin Drugs 0.000 description 1
• 208000019425 cirrhosis of liver Diseases 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 238000011509 clonal analysis Methods 0.000 description 1
• 239000013599 cloning vector Substances 0.000 description 1
• 229960002424 collagenase Drugs 0.000 description 1
• 238000002648 combination therapy Methods 0.000 description 1
• 238000011284 combination treatment Methods 0.000 description 1
• 230000030944 contact inhibition Effects 0.000 description 1
• 230000000875 corresponding effect Effects 0.000 description 1
• 201000003740 cowpox Diseases 0.000 description 1
• 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
• 230000009089 cytolysis Effects 0.000 description 1
• 230000003013 cytotoxicity Effects 0.000 description 1
• 231100000135 cytotoxicity Toxicity 0.000 description 1
• 230000007812 deficiency Effects 0.000 description 1
• 230000000593 degrading effect Effects 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 238000002716 delivery method Methods 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• 238000010586 diagram Methods 0.000 description 1
• 235000015872 dietary supplement Nutrition 0.000 description 1
• 206010012818 diffuse large B-cell lymphoma Diseases 0.000 description 1
• 238000006471 dimerization reaction Methods 0.000 description 1
• 210000001840 diploid cell Anatomy 0.000 description 1
• 229920002549 elastin Polymers 0.000 description 1
• 230000002124 endocrine Effects 0.000 description 1
• 230000003511 endothelial effect Effects 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 229940105423 erythropoietin Drugs 0.000 description 1
• 230000001076 estrogenic effect Effects 0.000 description 1
• 210000003527 eukaryotic cell Anatomy 0.000 description 1
• 210000002744 extracellular matrix Anatomy 0.000 description 1
• 229950003662 fenretinide Drugs 0.000 description 1
• 229940012952 fibrinogen Drugs 0.000 description 1
• 229940126864 fibroblast growth factor Drugs 0.000 description 1
• 108090000047 fibroblast growth factor 13 Proteins 0.000 description 1
• 230000003176 fibrotic effect Effects 0.000 description 1
• 230000004992 fission Effects 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• 230000002538 fungal effect Effects 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 238000012239 gene modification Methods 0.000 description 1
• 230000005017 genetic modification Effects 0.000 description 1
• 235000013617 genetically modified food Nutrition 0.000 description 1
• 231100000734 genotoxic potential Toxicity 0.000 description 1
• 239000003862 glucocorticoid Substances 0.000 description 1
• 235000011187 glycerol Nutrition 0.000 description 1
• 230000002710 gonadal effect Effects 0.000 description 1
• 239000003163 gonadal steroid hormone Substances 0.000 description 1
• 239000000122 growth hormone Substances 0.000 description 1
• 101150028578 grp78 gene Proteins 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 210000002064 heart cell Anatomy 0.000 description 1
• 229910001385 heavy metal Inorganic materials 0.000 description 1
• 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
• 230000002607 hemopoietic effect Effects 0.000 description 1
• 230000013632 homeostatic process Effects 0.000 description 1
• 230000005571 horizontal transmission Effects 0.000 description 1
• 235000003642 hunger Nutrition 0.000 description 1
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
• 230000000729 hypotrophic effect Effects 0.000 description 1
• 210000000987 immune system Anatomy 0.000 description 1
• 230000007813 immunodeficiency Effects 0.000 description 1
• 238000003364 immunohistochemistry Methods 0.000 description 1
• 239000000367 immunologic factor Substances 0.000 description 1
• 230000002779 inactivation Effects 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• 230000001939 inductive effect Effects 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• 206010022000 influenza Diseases 0.000 description 1
• 239000003999 initiator Substances 0.000 description 1
• 102000006495 integrins Human genes 0.000 description 1
• 108010044426 integrins Proteins 0.000 description 1
• 102000004114 interleukin 20 Human genes 0.000 description 1
• 108090000681 interleukin 20 Proteins 0.000 description 1
• 108010074108 interleukin-21 Proteins 0.000 description 1
• 230000000968 intestinal effect Effects 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 230000031146 intracellular signal transduction Effects 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000007912 intraperitoneal administration Methods 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• UHEBDUAFKQHUBV-UHFFFAOYSA-N jspy-st000261 Chemical compound C1=CC=C2C3=C(C(=O)NC4)C4=C(C=4C(=CC=C(C=4)COC(C)C)N4CCCOC(=O)CN(C)C)C4=C3CC2=C1 UHEBDUAFKQHUBV-UHFFFAOYSA-N 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 208000011824 leiomyosarcoma of the corpus uteri Diseases 0.000 description 1
• WOSKHXYHFSIKNG-UHFFFAOYSA-N lenvatinib Chemical compound C=12C=C(C(N)=O)C(OC)=CC2=NC=CC=1OC(C=C1Cl)=CC=C1NC(=O)NC1CC1 WOSKHXYHFSIKNG-UHFFFAOYSA-N 0.000 description 1
• YDTFRJLNMPSCFM-YDALLXLXSA-M levothyroxine sodium anhydrous Chemical compound [Na+].IC1=CC(C[C@H](N)C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 YDTFRJLNMPSCFM-YDALLXLXSA-M 0.000 description 1
• MPVGZUGXCQEXTM-UHFFFAOYSA-N linifanib Chemical compound CC1=CC=C(F)C(NC(=O)NC=2C=CC(=CC=2)C=2C=3C(N)=NNC=3C=CC=2)=C1 MPVGZUGXCQEXTM-UHFFFAOYSA-N 0.000 description 1
• 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
• 201000006721 lip cancer Diseases 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 229940076783 lucentis Drugs 0.000 description 1
• 239000001095 magnesium carbonate Substances 0.000 description 1
• ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
• 229960001708 magnesium carbonate Drugs 0.000 description 1
• 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
• 235000014380 magnesium carbonate Nutrition 0.000 description 1
• 230000003211 malignant effect Effects 0.000 description 1
• 210000005075 mammary gland Anatomy 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 239000003550 marker Substances 0.000 description 1
• 239000011159 matrix material Substances 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 210000004779 membrane envelope Anatomy 0.000 description 1
• 108091056924 miR-124 stem-loop Proteins 0.000 description 1
• 108091055042 miR-181 stem-loop Proteins 0.000 description 1
• 108091062762 miR-21 stem-loop Proteins 0.000 description 1
• 108091041631 miR-21-1 stem-loop Proteins 0.000 description 1
• 108091044442 miR-21-2 stem-loop Proteins 0.000 description 1
• 108091046553 miR-26 stem-loop Proteins 0.000 description 1
• 108091023821 miR-26-1 stem-loop Proteins 0.000 description 1
• 108091045094 miR-26-2 stem-loop Proteins 0.000 description 1
• 108091086713 miR-96 stem-loop Proteins 0.000 description 1
• 108091070961 miR-96-3 stem-loop Proteins 0.000 description 1
• 235000021239 milk protein Nutrition 0.000 description 1
• RAHBGWKEPAQNFF-UHFFFAOYSA-N motesanib Chemical compound C=1C=C2C(C)(C)CNC2=CC=1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 RAHBGWKEPAQNFF-UHFFFAOYSA-N 0.000 description 1
• 210000000663 muscle cell Anatomy 0.000 description 1
• 210000000272 myelencephalon Anatomy 0.000 description 1
• LBWFXVZLPYTWQI-IPOVEDGCSA-N n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C LBWFXVZLPYTWQI-IPOVEDGCSA-N 0.000 description 1
• JXSVVZKPEDIRTN-DHZHZOJOSA-N n-[2-fluoro-5-[[3-[(e)-2-pyridin-2-ylethenyl]-1h-indazol-6-yl]amino]phenyl]-2,5-dimethylpyrazole-3-carboxamide Chemical compound CN1N=C(C)C=C1C(=O)NC1=CC(NC=2C=C3NN=C(\C=C\C=4N=CC=CC=4)C3=CC=2)=CC=C1F JXSVVZKPEDIRTN-DHZHZOJOSA-N 0.000 description 1
• 201000011216 nasopharynx carcinoma Diseases 0.000 description 1
• 239000013642 negative control Substances 0.000 description 1
• 210000003360 nephrocyte Anatomy 0.000 description 1
• 230000001537 neural effect Effects 0.000 description 1
• 229960004378 nintedanib Drugs 0.000 description 1
• XZXHXSATPCNXJR-ZIADKAODSA-N nintedanib Chemical compound O=C1NC2=CC(C(=O)OC)=CC=C2\C1=C(C=1C=CC=CC=1)\NC(C=C1)=CC=C1N(C)C(=O)CN1CCN(C)CC1 XZXHXSATPCNXJR-ZIADKAODSA-N 0.000 description 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
• 239000002777 nucleoside Substances 0.000 description 1
• 235000015097 nutrients Nutrition 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 201000007052 paranasal sinus cancer Diseases 0.000 description 1
• 230000036961 partial effect Effects 0.000 description 1
• 229960003407 pegaptanib Drugs 0.000 description 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 1
• 230000035479 physiological effects, processes and functions Effects 0.000 description 1
• 210000002826 placenta Anatomy 0.000 description 1
• 239000013641 positive control Substances 0.000 description 1
• 244000144977 poultry Species 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 108091007428 primary miRNA Proteins 0.000 description 1
• 108010042121 probasin Proteins 0.000 description 1
• 238000012545 processing Methods 0.000 description 1
• 230000000750 progressive effect Effects 0.000 description 1
• 210000001236 prokaryotic cell Anatomy 0.000 description 1
• 230000002685 pulmonary effect Effects 0.000 description 1
• 239000002516 radical scavenger Substances 0.000 description 1
• 238000001959 radiotherapy Methods 0.000 description 1
• 229960002633 ramucirumab Drugs 0.000 description 1
• 229960003876 ranibizumab Drugs 0.000 description 1
• 230000010837 receptor-mediated endocytosis Effects 0.000 description 1
• 230000006798 recombination Effects 0.000 description 1
• 238000005215 recombination Methods 0.000 description 1
• 208000016691 refractory malignant neoplasm Diseases 0.000 description 1
• 229960004836 regorafenib Drugs 0.000 description 1
• FNHKPVJBJVTLMP-UHFFFAOYSA-N regorafenib Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 FNHKPVJBJVTLMP-UHFFFAOYSA-N 0.000 description 1
• 210000005000 reproductive tract Anatomy 0.000 description 1
• 238000012827 research and development Methods 0.000 description 1
• 210000003705 ribosome Anatomy 0.000 description 1
• KGFYHTZWPPHNLQ-AWEZNQCLSA-N rivaroxaban Chemical compound S1C(Cl)=CC=C1C(=O)NC[C@@H]1OC(=O)N(C=2C=CC(=CC=2)N2C(COCC2)=O)C1 KGFYHTZWPPHNLQ-AWEZNQCLSA-N 0.000 description 1
• 201000003804 salivary gland carcinoma Diseases 0.000 description 1
• 150000003839 salts Chemical class 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 230000001932 seasonal effect Effects 0.000 description 1
• 238000012163 sequencing technique Methods 0.000 description 1
• 239000003352 sequestering agent Substances 0.000 description 1
• 235000015170 shellfish Nutrition 0.000 description 1
• 229910052709 silver Inorganic materials 0.000 description 1
• 201000000849 skin cancer Diseases 0.000 description 1
• 201000008261 skin carcinoma Diseases 0.000 description 1
• 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 229960003787 sorafenib Drugs 0.000 description 1
• 229950001248 squalamine Drugs 0.000 description 1
• 206010041823 squamous cell carcinoma Diseases 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 230000037351 starvation Effects 0.000 description 1
• 150000003431 steroids Chemical class 0.000 description 1
• 239000011550 stock solution Substances 0.000 description 1
• 208000003265 stomatitis Diseases 0.000 description 1
• 238000005728 strengthening Methods 0.000 description 1
• 108091007196 stromelysin Proteins 0.000 description 1
• 235000000346 sugar Nutrition 0.000 description 1
• 229960001796 sunitinib Drugs 0.000 description 1
• WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 description 1
• 239000013589 supplement Substances 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 229940034785 sutent Drugs 0.000 description 1
• 230000009182 swimming Effects 0.000 description 1
• 238000003786 synthesis reaction Methods 0.000 description 1
• 230000002194 synthesizing effect Effects 0.000 description 1
• 238000007910 systemic administration Methods 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 235000012222 talc Nutrition 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 229950003046 tesevatinib Drugs 0.000 description 1
• 231100001274 therapeutic index Toxicity 0.000 description 1
• 201000002510 thyroid cancer Diseases 0.000 description 1
• 208000013077 thyroid gland carcinoma Diseases 0.000 description 1
• 239000004408 titanium dioxide Substances 0.000 description 1
• 201000006134 tongue cancer Diseases 0.000 description 1
• 230000000699 topical effect Effects 0.000 description 1
• 108010014677 transcription factor TFIIE Proteins 0.000 description 1
• 108010014678 transcription factor TFIIF Proteins 0.000 description 1
• 230000001131 transforming effect Effects 0.000 description 1
• 230000014621 translational initiation Effects 0.000 description 1
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
• 231100000588 tumorigenic Toxicity 0.000 description 1
• 230000000381 tumorigenic effect Effects 0.000 description 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
• 208000010576 undifferentiated carcinoma Diseases 0.000 description 1
• 241001529453 unidentified herpesvirus Species 0.000 description 1
• 230000002792 vascular Effects 0.000 description 1
• 235000013311 vegetables Nutrition 0.000 description 1
• 239000013603 viral vector Substances 0.000 description 1
• 210000002845 virion Anatomy 0.000 description 1
• 230000029302 virus maturation Effects 0.000 description 1
• 239000011782 vitamin Substances 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 150000003722 vitamin derivatives Chemical class 0.000 description 1
• 108010025625 vocimagene amiretrorepvec Proteins 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
• 230000003313 weakening effect Effects 0.000 description 1
• 229940055725 xarelto Drugs 0.000 description 1
• 210000005253 yeast cell Anatomy 0.000 description 1