CN105561018A - Traditional Chinese medicine composition for treating liver-stagnation with spleen-deficiency type hyperthyroidism complicating nodal tachycardia - Google Patents

Abstract

The invention belongs to the technical field of medicines and in particular relates to a traditional Chinese medicine composition for treating liver-stagnation with spleen-deficiency type hyperthyroidism complicating nodal tachycardia. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 4-8 parts of amorphophallus virosus, 4-8 parts of sambucus chinensis, 4-8 parts of radix scoparius, 4-8 parts of semen aesculi, 4-8 parts of fragrant sarcococca herbs, 4-8 parts of sorghum, 4-8 parts of nutgrass flatsedge, 4-8 parts of Gerbera delauayi Franch., 4-8 parts of Calastrus flagellaris Rupr., 4-8 parts of ziziphora clinopodioides lam and 4-8 parts of radix glycyrrhizae. The combination of the components has the effect of soothing liver and strengthening spleen, and quieting the heat and calming the nerves, and can reduce the average heart rate, convert to sinus rhythm and restore the thyroid function level.

Description

A kind of Chinese medicine composition for the treatment of liver-depression and spleen-insufficiency type hyperthyroidism and merging sinus tachycardia

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine composition for the treatment of liver-depression and spleen-insufficiency type hyperthyroidism and merging sinus tachycardia.

Background technology

Hyperthyroidism can cause different ARR generation, arrhythmia is even the medical symptom and sign occurred the earliest sometimes, most of patients is that onset symptoms is gone to a doctor with arrhythmia, and patient is tachy-arrhythmia, and wherein sinus tachycardia and atrial fibrillation are modal types.Easily there is mistaken diagnosis, fail to pinpoint a disease in diagnosis in hyperthyroid arrhythmia, delay treatment, and primary disease treatment cycle is longer, and symptom is not easily alleviated, and easily recur, as malpractice or delay treatment, great infringement can be caused to cardiac structure and physiological function, even produce irreversibility heart change.

The pathogeny that current doctor trained in Western medicine merges sinus tachycardia for hyperthyroidism still imperfectly understands, and treatment aspect there is no effective Therapeutic Method.

Liver-depression and spleen-insufficiency type is that hyperthyroidism merges the common type of sinus tachycardia, has not yet to see the medicine being exclusively used in such hyperthyroidism and merging sinus tachycardia.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of Chinese medicine composition for the treatment of liver-depression and spleen-insufficiency type hyperthyroidism and merging sinus tachycardia.

The present invention is achieved through the following technical solutions:

Treat the Chinese medicine composition that liver-depression and spleen-insufficiency type hyperthyroidism merges sinus tachycardia, be made up of the Chinese medicine of following weight portion:

Rhizoma Amorphophalli virosi 4-8 part, Herba Sambuci Chiensis 4-8 part, Radix Indigoferae Szechuenensis 4-8 part, Semen Aesculi 4-8 part, Sarcococca ruscifolia Stapf 4-8 part, Sorghum vulgare Pers. 4-8 part, dried tuber 4-8 part, Bai Ye do not turn over 4-8 part, sting luxuriant fruits of Celastrus orbiculatus Thunb 4-8 part, lip Rhizoma et radix valerianae 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, above-mentioned treatment liver-depression and spleen-insufficiency type hyperthyroidism merges the Chinese medicine composition of sinus tachycardia, is made up of the Chinese medicine of following weight portion:

Rhizoma Amorphophalli virosi 5-7 part, Herba Sambuci Chiensis 5-7 part, Radix Indigoferae Szechuenensis 5-7 part, Semen Aesculi 5-7 part, Sarcococca ruscifolia Stapf 5-7 part, Sorghum vulgare Pers. 5-7 part, dried tuber 5-7 part, Bai Ye do not turn over 5-7 part, sting luxuriant fruits of Celastrus orbiculatus Thunb 5-7 part, lip Rhizoma et radix valerianae 5-7 part, Radix Glycyrrhizae 5-7 part.

Preferred, above-mentioned treatment liver-depression and spleen-insufficiency type hyperthyroidism merges the Chinese medicine composition of sinus tachycardia, is made up of the Chinese medicine of following weight portion:

Rhizoma Amorphophalli virosi 6 parts, Herba Sambuci Chiensis 6 parts, Radix Indigoferae Szechuenensis 6 parts, Semen Aesculi 6 parts, Sarcococca ruscifolia Stapf 6 parts, Sorghum vulgare Pers. 6 parts, dried tuber 6 parts, Bai Ye do not turn over 6 parts, sting luxuriant fruits of Celastrus orbiculatus Thunb 6 parts, lip Rhizoma et radix valerianae 6 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of liver-depression and spleen-insufficiency type hyperthyroidism and merge sinus tachycardia.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In Chinese medicine composition of the present invention,

Rhizoma Amorphophalli virosi another name Rhizoma Amorphophalli virosi, Rhizoma Arisaematis head, southern taro are the tuber of aroid wart handle mill taro AmorphophallusvirosusN.E.Browu.Acrid in the mouth; Sweet; Slightly warm in nature.Function soothing liver and strengthening spleen; Detoxicating and resolving stagnation of pathogens.Main chronic persistent hepatitis.

Herba Sambuci Chiensis is the flower of caprifoliaceae plant Herba sambuci chinensis.Bitter in the mouth is pungent, cold in nature.Return Liver Channel.Function soothing liver and strengthening spleen, blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema.For acute viral hepatitis, oedema due to nephritis, rheumatalgia, dislocation, oedema due to nephritis, beriberi edema, urticaria, injury from falling down, fracture.

Radix Indigoferae Szechuenensis another name Flos Caraganae Sinicae is root or the aerial parts of leguminous plant Sichuan Drymotaenium miyoshianum (Mak.) Mak. IndigoferaszechuensisCraib.Acrid in the mouth; Bitter; Slightly warm in nature.Return liver; Stomach; Lung meridian.Function regulating the flow of QI to ease the stomach; Heat-clearing and toxic substances removing.Main gastric abscess; Tripe abdomen cold type of pain; Chest and diaphragm distension; Pulmonary tuberculosis is generated heat; Sore swollen toxin.

Semen Aesculi another name SEMEN AESCULI is Hippocastanaceae plant Aesculus chinensis Bunge AesculuschinensisBge., Radix Aesculi AesculuschinensisBge.var.chekiangensis(HuetFang) dry mature seed of Fang or Aesculus AesculuswilsoniiRehd..Sweet in the mouth, warm in nature.Return liver, stomach warp.Function regulating the flow of QI to ease the stomach, and stomach and alleviating pain.Vexed for breast abdominal distention, gastralgia.

Sarcococca ruscifolia Stapf fruit derives from Buxaceae Sarcococca plant fragrance osmanthus SarcococcaruscifoliaStapf, with fruit medicine.Nature and flavor are pungent, bitter, flat.The nourishing the liver of function blood.For dizziness, cardiopalmus, visual deterioration.

Sorghum vulgare Pers. call wooden millet, chinese sorghum, another name for Sichuan Province sorghum, sorgo, be the kernel of grass Sorghum vulgare Pers. SorghumvulgarePers..Sweet in the mouth; Puckery; Warm in nature.Return spleen; Stomach; Lung meridian.Function invigorating the spleen to arrest diarrhea; Reduce phlegm and calm the nerves.Main diarrhea due to hypofunction of the spleen; Cholera; Dyspepsia; Productive cough due to phlegm-damp; Insomnia and dreamful sleep.

Nutgrass flatsedge call Sha Sui, hao marquis, Sha, hair, later green grass or young crops, wild leek, overnightly take out, trench grass, little Rhizoma Sparganii, measle, contracting contracting are careless, pass through grass, adiantum cpilus-veneris, cake grass, hang horse palm fibre, native vanilla, pig hair green grass or young crops, convexutricle sedge herb.For the stem and leaf of dried tuber tannin plant dried tuber CyperusrotundusL..Bitter in the mouth; Pungent; Cool in nature.Return liver; Lung meridian.Function activating QI to alleviate the depression; Dispelling wind for relieving itching; Wide born of the same parents' profit expectorant.Master is uncomfortable in chest does not relax; Rubella pruritus; Carbuncle is with toxic swelling.

Bai Ye does not turn over another name Radix Gerberae Delavayi, large fire weed, Rhizoma Chiritae Eburneae fire weed, little Herba Ophioglossi, the Radix Pulsatillae, is the root of feverfew hook bud Herba Leibnitziae GerberadelauayiFranch. [G.hen-ryiDunn].Acrid in the mouth; Micro-hardship; Property is put down.Function removing heat-phlegm; Removing food stagnancy kills early.Main flu; Cough and asthma; Dysentery; Stomachache; Dyspepsia; Ascariasis; Traumatic hemorrhage.

Sting the fruit that luxuriant fruits of Celastrus orbiculatus Thunb is Celastraceae plant Radix Seu Caulis Celastri Flagellaris CelastrusflagellarisRupr..Bitter in the mouth; Pungent; Property is put down.Function mind tranquilizing and the heart calming; Activating collaterals to relieve pain; Removing toxic substances and promoting subsidence of swelling.Main palpitation and insomnia; Bones and muscles pain; Waist lower limb is numb; Toothache; Sore swollen toxin.

Lip Rhizoma et radix valerianae another name Herba Ziziphorae clinopodioidis, Herba Dracocephali are the Herb of labiate lip Rhizoma et radix valerianae ZiziphoraclinopodioidesLam..Acrid in the mouth; Cool in nature.Function mind tranquilizing and the heart calming; Diuretic heat clearing away.Main cardiopalmus; Insomnia; Edema; Cold, fever; Conjunctival congestion and swelling pain; Sore swollen toxin.

Radix Glycyrrhizae is sweet, flat.GUIXIN, lung, spleen, stomach warp.Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Although the traditional Chinese medical science does not have hyperthyroidism to merge the name of disease of sinus tachycardia, the feature such as to become thin according to its throat enlargement, cardiopalmus, nervous, irritable excited, aversion to heat hyperhidrosis, dry mouth and throat, polyphagia, the ownership traditional Chinese medical science " goiter ", " cardiopalmus " category.The present inventor sums up years of work experience, and think that primary disease is how relevant with stagnation of liver-QI with deficiency of the spleen, goiter mostly is emotion pathopoiesis, and patient's irritability is not dredged, and perverse and unreasonable manner violates spleen, the spleen being the source of producing phlegm, phlegm-damp accumulation symptom with the passing of time heat-transformation, disturbing the mind upwards, and sees the symptoms such as cardiopalmus, dizziness, insomnia.Therefore treat liver-depression and spleen-insufficiency type hyperthyroidism with soothing liver and strengthening spleen, mind tranquilizing and the heart calming ruling by law and merge sinus tachycardia.

Chinese medicine composition of the present invention, its prescription machine is as follows:

Monarch drug: Rhizoma Amorphophalli virosi, Herba Sambuci Chiensis merit are with soothing liver and strengthening spleen.

Ministerial drug: Radix Indigoferae Szechuenensis, Semen Aesculi merit are with regulating the flow of QI to ease the stomach.

Adjuvant drug: Sarcococca ruscifolia Stapf merit is with replenishing blood and nourishing liver; Dried tuber merit is with activating QI to alleviate the depression; Sorghum vulgare Pers. merit is calmed the nerves with invigorating the spleen for dissipating phlegm; Bai Ye does not turn over merit with removing heat-phlegm; Sting luxuriant fruits of Celastrus orbiculatus Thunb, lip Rhizoma et radix valerianae merit with mind tranquilizing and the heart calming.

Make medicine: Radix Glycyrrhizae merit is with coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, and all medicines share the effect of common long memorial liver spleen, mind tranquilizing and the heart calming.Liver-depression and spleen-insufficiency type hyperthyroidism of linking closely merges the pathogenesis of sinus tachycardia.Can improve clinical symptoms, reduce average heart rate, turn multiple sinus rhythm, recover thyroid function level, and safety indexes is without impact, safety is good.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat the Chinese medicine composition that liver-depression and spleen-insufficiency type hyperthyroidism merges sinus tachycardia, each crude drug weight proportion is as follows:

Rhizoma Amorphophalli virosi 6g, Herba Sambuci Chiensis 6g, Radix Indigoferae Szechuenensis 6g, Semen Aesculi 6g, Sarcococca ruscifolia Stapf 6g, Sorghum vulgare Pers. 6g, dried tuber 6g, Bai Ye do not turn over 6g, sting luxuriant fruits of Celastrus orbiculatus Thunb 6g, lip Rhizoma et radix valerianae 6g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat the Chinese medicine composition that liver-depression and spleen-insufficiency type hyperthyroidism merges sinus tachycardia, each crude drug weight proportion is as follows:

Rhizoma Amorphophalli virosi 5g, Herba Sambuci Chiensis 7g, Radix Indigoferae Szechuenensis 5g, Semen Aesculi 7g, Sarcococca ruscifolia Stapf 5g, Sorghum vulgare Pers. 7g, dried tuber 5g, Bai Ye do not turn over 7g, sting luxuriant fruits of Celastrus orbiculatus Thunb 7g, lip Rhizoma et radix valerianae 5g, Radix Glycyrrhizae 7g.

Embodiment 3

Treat the Chinese medicine composition that liver-depression and spleen-insufficiency type hyperthyroidism merges sinus tachycardia, each crude drug weight proportion is as follows:

Rhizoma Amorphophalli virosi 7g, Herba Sambuci Chiensis 5g, Radix Indigoferae Szechuenensis 7g, Semen Aesculi 5g, Sarcococca ruscifolia Stapf 7g, Sorghum vulgare Pers. 5g, dried tuber 7g, Bai Ye do not turn over 5g, sting luxuriant fruits of Celastrus orbiculatus Thunb 5g, lip Rhizoma et radix valerianae 7g, Radix Glycyrrhizae 5g.

Embodiment 4

Treat the Chinese medicine composition that liver-depression and spleen-insufficiency type hyperthyroidism merges sinus tachycardia, each crude drug weight proportion is as follows:

Rhizoma Amorphophalli virosi 4g, Herba Sambuci Chiensis 8g, Radix Indigoferae Szechuenensis 4g, Semen Aesculi 8g, Sarcococca ruscifolia Stapf 4g, Sorghum vulgare Pers. 8g, dried tuber 4g, Bai Ye do not turn over 8g, sting luxuriant fruits of Celastrus orbiculatus Thunb 8g, lip Rhizoma et radix valerianae 4g, Radix Glycyrrhizae 8g.

Embodiment 5

Treat the Chinese medicine composition that liver-depression and spleen-insufficiency type hyperthyroidism merges sinus tachycardia, each crude drug weight proportion is as follows:

Rhizoma Amorphophalli virosi 8g, Herba Sambuci Chiensis 4g, Radix Indigoferae Szechuenensis 8g, Semen Aesculi 4g, Sarcococca ruscifolia Stapf 8g, Sorghum vulgare Pers. 4g, dried tuber 8g, Bai Ye do not turn over 4g, sting luxuriant fruits of Celastrus orbiculatus Thunb 4g, lip Rhizoma et radix valerianae 8g, Radix Glycyrrhizae 4g.

Carried out clinical pharrnacokinetics test to Chinese medicine composition of the present invention, Details as Follows:

1. data and method

1.1 object of study

Choose liver-depression and spleen-insufficiency type hyperthyroidism and merge sinus tachycardia patient 140 example, wherein man 49 example, female 91 example, the mean age (47.42 ± 12.54) year.

1.2 Western medicine diagnose standards

Formulate according to " practical internal medicine " and " inner-sphere reorganization energy ".

1. hyperthyroidism: FT3, FT4 level raises, TSH level reduces.

2. sinus tachycardia: P ripple is sinus, and frequency mostly is 100-150 beat/min, is generally no more than 160 beats/min.

1.3 differential diagnosis in tcm standards

Diagnostic criteria with reference to " syndrome of stagnation of liver qi and spleen deficiency " in " new Chinese medicine guideline of clinical investigations ": primary symptom: palpitation and uneasiness, to be in a very depressed state or being irritable and getting angry easily, gastral cavilty or the breast side of body are done swollen, and sighing frequently is tired.Secondary disease: throat enlargement, the dry margins of eyelids of eye, dizziness, insomnia forgetfulness, shallow complexion, tastelessness, lack of appetite, loose stool.Picture of the tongue pulse condition: enlarged tongue or pale tongue, white and thin fur or satiny, stringy and rolling pulse or thin.All possess primary symptom and secondary disease more than two persons, and can make a definite diagnosis with reference to tongue arteries and veins.

1.4 inclusive criteria

1. Informed Consent Form is signed.

2. 18 ~ 70 years old age.

3. Chinese and western medicine diagnostic criteria is met.

4. before patient enters group, Zhou Wei takes the depressed medicine of anxiety or antipsychotics.

1.5 exclusion standard

1. age <18 year or >70 year patient.

2. gestation or women breast-feeding their children.

3. there are the cardiovascular disease such as acute myocardial infarction, cardiogenic shock, advanced heart failure, severe arrhythmia, merge severe hypertension, severe pulmonary insufficiency, bronchial asthma, hepatic and renal function injure, disease of hematopoietic system or psychotic.

4. the person that has hyperthyroidism crisis.

5. thyroid enlarges markedly and produces pressure symptom person to adjacent organs.

6. various thyroiditis.

7. use other medications, particularly have the medicine of considerable influence (as taken Folium Digitalis Purpureae, potassium salt, turning class and antiarrhythmic drug) to trial drug, affect effectiveness and safety judgement person.

8. allergic constitution or easy in multi-medicament allergy sufferers.

1.6 cases are rejected and are come off standard

1. allly inclusive criteria is not met and the case be strayed into should be rejected;

2. irregular observation measure or data not umbra ring and observe judgement person and should reject.

3. observe in patient voluntarily bolter should be considered as coming off;

4. occur that adverse events should not continue observer and be considered as coming off in observing.

1.7 Therapeutic Method

Adopt the Chinese medicine composition oral medication of the embodiment of the present invention 1, prescription is as follows: Rhizoma Amorphophalli virosi 6g, Herba Sambuci Chiensis 6g, Radix Indigoferae Szechuenensis 6g, Semen Aesculi 6g, Sarcococca ruscifolia Stapf 6g, Sorghum vulgare Pers. 6g, dried tuber 6g, Bai Ye do not turn over 6g, sting luxuriant fruits of Celastrus orbiculatus Thunb 6g, lip Rhizoma et radix valerianae 6g, Radix Glycyrrhizae 6g, be decocted in water for oral dose, day potion, sooner or later sub-service is a course for the treatment of with 7d.

1.8 treatment fore-and-aft observing indexs

(1) thyroid function: FT3, FT4, TSH.

(2) ambulatory electrocardiogram: record average heart rate, abnormal heart rhythm number of times and conclusion.

(3) TCM syndrome integration: with reference to " new Chinese medicine clinical research medication guide principle ", according to nothing, gently, in, heavy, be designated as 0 respectively, 1,2,3 points.

(4) safety indexes: to the forward and backward mensuration hematuria routine of patient treatment, liver function, kidney merit, electrocardiogram etc.

1.9 TCM syndrome therapeutic evaluatioies

" new Chinese medicine clinical research medication guide principle " that evaluation criteria was promulgated with reference to 2002.

1. fully recover: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%

2. effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%

3. effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%

4. invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces <30%.

Computing formula: nimodipine method: integration × 100% before (before treatment the rear integration of integration-treatment)/treatment.

1.10 statistical method

SPSS14.0 version statistical software is adopted to analyze.Measurement data represents with mean plus-minus standard deviation, and compare before and after treatment and adopt t inspection, enumeration data represents with percentage rate, compares employing X 2 test, represent that difference has statistical significance with P<0.05 before and after treatment.

2. result

The 2.1 treatment forward backward averaging rhythms of the heart compare

After treatment, mean heart rate is (74.35 ± 4.57) beat/min, and (116.22 ± 9.48) beat/min comparatively before treatment, obviously reduce, difference has statistical significance (t=4.854, P<0.05).

Thyroid function before and after 2.2 treatments

After treatment, FT3, FT4 obviously reduce before all comparatively treating, and obviously raise before TSH comparatively treats, difference has statistical significance (P<0.05), in table 1.

Table 1 is treated front and back thyroid function and is compared

Time	Number of cases	FT3	FT4	TSH
					Before treatment	140	12.84±2.26	24.93±3.59	0.32±0.14
After treatment	140	3.18±0.56	5.28±1.47	2.53±0.38
					T value	--	4.495	5.435	5.996
P value	--	0.025	0.022	0.018

TCM syndrome integration and TCM syndrome curative effect before and after 2.3 treatments

TCM syndrome total mark (5.28 ± 1.34) point after treatment, (26.78 ± 4.55) point comparatively before treatment obviously reduce, and difference has statistical significance (t=5.593, P<0.05); 140 routine patient's TCM syndrome curative effects: cure 128 examples, effective 8 examples, effective 4 examples, invalid 0 example.Curative effect: cure rate 91.4%, total obvious effective rate 97.1%, total effective rate is 100%.

2.4 safety analysis

Treatment Patients Before And After routine blood test, Liver and kidney merit are without significant change, and drug safety is better.

Claims (3)

1. treat the Chinese medicine composition that liver-depression and spleen-insufficiency type hyperthyroidism merges sinus tachycardia, be made up of the Chinese medicine of following weight portion:

Rhizoma Amorphophalli virosi 4-8 part, Herba Sambuci Chiensis 4-8 part, Radix Indigoferae Szechuenensis 4-8 part, Semen Aesculi 4-8 part, Sarcococca ruscifolia Stapf 4-8 part, Sorghum vulgare Pers. 4-8 part, dried tuber 4-8 part, Bai Ye do not turn over 4-8 part, sting luxuriant fruits of Celastrus orbiculatus Thunb 4-8 part, lip Rhizoma et radix valerianae 4-8 part, Radix Glycyrrhizae 4-8 part.

2. treatment liver-depression and spleen-insufficiency type hyperthyroidism according to claim 1 merges the Chinese medicine composition of sinus tachycardia, it is characterized in that, is made up of the Chinese medicine of following weight portion:

Rhizoma Amorphophalli virosi 5-7 part, Herba Sambuci Chiensis 5-7 part, Radix Indigoferae Szechuenensis 5-7 part, Semen Aesculi 5-7 part, Sarcococca ruscifolia Stapf 5-7 part, Sorghum vulgare Pers. 5-7 part, dried tuber Sorghum vulgare Pers. 5-7 part, Bai Ye do not turn over Sorghum vulgare Pers. 5-7 part, sting luxuriant fruits of Celastrus orbiculatus Thunb 5-7 part, lip Rhizoma et radix valerianae 5-7 part, Radix Glycyrrhizae 5-7 part.

3. treatment liver-depression and spleen-insufficiency type hyperthyroidism according to claim 3 merges the Chinese medicine composition of sinus tachycardia, it is characterized in that, is made up of the Chinese medicine of following weight portion:

Rhizoma Amorphophalli virosi 6 parts, Herba Sambuci Chiensis 6 parts, Radix Indigoferae Szechuenensis 6 parts, Semen Aesculi 6 parts, Sarcococca ruscifolia Stapf 6 parts, Sorghum vulgare Pers. 6 parts, dried tuber 6 parts, Bai Ye do not turn over 6 parts, sting luxuriant fruits of Celastrus orbiculatus Thunb 6 parts, lip Rhizoma et radix valerianae 6 parts, 6 parts, Radix Glycyrrhizae.