CN105561005B - Gynaecopathia external prescription and use in conjunction thereof - Google Patents
Gynaecopathia external prescription and use in conjunction thereof Download PDFInfo
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- CN105561005B CN105561005B CN201610078422.XA CN201610078422A CN105561005B CN 105561005 B CN105561005 B CN 105561005B CN 201610078422 A CN201610078422 A CN 201610078422A CN 105561005 B CN105561005 B CN 105561005B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
Gynaecopathia external prescription and use in conjunction thereof.Present invention provide for prevention or treatment gynaecopathia kit and external wash liquid therein and vaginal suppository, it includes Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, Cortex Dictamni, Borax (or Alumen) and Borneolum Syntheticum.This kit is comprised for preventing or treat cervicitis and/or vaginitis and/or recovering the medicine of pelvic floor function it addition, present invention also offers.
Description
Technical field
The invention belongs to pharmaceutical technology field, specifically, the invention provides external wash liquid and and vaginal suppository thereof
The use in conjunction of agent, becomes kit including co-formulated, is used for preventing or treating gynaecopathia, e.g., prevention or
Treat cervicitis and/or vaginitis and/or recover pelvic floor function.
Background technology
Vaginitis is commonly encountered diseases and the frequently-occurring disease of gynecological, causes leucorrhoea grow in quantity, pruritus and stench, affects sexual life,
Induction cervicitis and infertility.According to the difference of pathogen infection, vaginitis is mainly segmented into trichomonas vagina
Inflammation, bacterial vaginitis and colpitis mycotica etc. three kinds.
If being currently used for treating, colpitic drug main is oral or vaginal suppository is administered antibiotic, as ornidazole,
Metronidazole, tinidazole, ofloxacin and ketoconazole etc., the most gradually develop immunity to drugs in crowd, and curative effect drops
Low it is obvious that and generally medication have the crowd of nearly 40% side effect or untoward reaction occur, vomit as felt sick
Tell, loss of appetite, erythra, diarrhoea etc., affect medication persistence (such as see Jiang Sufang. oral ornidazole with
The drug effect of tinidazole in treatment trichomonal vaginitis patient and safety evaluatio. Strait Pharmaceutical Journal, 24 (5): 148),
The most gradually substituted by medicine more newly developed, less employ.
Treatment by Chinese herbs gynaecopathia also has been reported that, such as, Chinese patent application the 95242889th discloses one
Kind of life gate umbilicus therapy health care bag, including taste crude drugs up to a hundred such as Radix Aconitis, is used for treating giddy, gynaecopathia, more
The chronic diseases such as term syndrome；It addition, Chinese patent application the 201410854365th discloses one and controls
Treat condyloma acuminatum Chinese medicine composition, including the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Fructus Toosendan, Rhizoma Cyperi, Rhizoma Curcumae,
Tens of taste crude drugs such as Rhizoma Sparganii, Radix Cyathulae, Radix Salviae Miltiorrhizae, Cortex Dictamni, take orally for this viral disease of anti-verruca acuminata
Sick.In these Chinese medicines, crude drug kind is many, complicated component, and the quality of production controls difficulty, limits actual application
Prospect.
The present inventor relies on long-term Couple herbs, and through arduous research, it is thus achieved that new prescription, especially join
Closing the prescription of application, it combines Chinese traditional treatment marrow, it is to avoid use the antibiotic such as ornidazole and tinidazole, logical
Cross the compatibility of drug-delivery preparation form and Chinese medicine, effectively prevent side effect and untoward reaction, and such compatibility
Create the colpitic effect of significant Synergistic treatment, especially make cure rate and obvious effective rate significantly improve,
Repair vagina.The most surprisingly, this prescription can also stimulate vagina contraction, recovers pelvic floor function, improves
Life quality.It addition, the kind of Chinese medicine crude drug is less in this prescription, it is easily controlled the quality of production, in addition originally
The cost of body medicine is relatively low, also need not use special administration device, therefore be easier to popularization and application.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of new prescription, is used for treating gynaecopathia.It addition,
The present invention also aims to provide the preparation method of this prescription, application etc..
Specifically, in first aspect, present invention provide for prevention or the Chinese medicine preparation for the treatment of gynaecopathia,
It is prepared from by following crude drug: Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, Cortex Dictamni, Borax and
Borneolum Syntheticum.It addition, for the lighter patient of the state of an illness, it is possible to use Alumen replaces the Borax in above-mentioned Chinese medicine preparation,
Thus the pharmaceutical composition of the present invention is prepared from by following crude drug: Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, little
Rice bar, Cortex Dictamni, Alumen and Borneolum Syntheticum.The hereafter term of preferred Borax, such as the weight ratio etc. of Borax, as without lance
In place of shield, can replace with Alumen.
In this article, gynaecopathia includes cervicitis, vaginitis and/or pelvic floor dysfunction etc., serious symptom vaginitis
Cervical erosion can be developed into.These inflammation are generally caused by infusorian, antibacterial or mycete, and pelvic floor function barrier
Hinder and be typically due to childbirth and cause.In an embodiment of the present invention, sets forth trichomonal vaginitis, beads
The treatment example of bacterium property vaginitis and pelvic floor dysfunction.
In this article, medicine material (i.e. crude drug, wherein raw material of Chinese medicine is also referred to as crude drug) itself is the most all
Dawn known to those skilled in the art, can commercially obtain.Due to Historic Evolution and the difference of region,
Crude drug title is more, and such as, Nidus Vespae is also known as Nidus Vespae；Alumen is also known as Alumen, Alumen；Semen setariae bar also known as millet straw,
It it is the straw separating Semen setariae (seed)；Cortex Ailanthi is also known as ailanthus altissima (mill.) swingle skin, smelly spring skin, but these call not shadow
Ring those skilled in the art these crude drugs are obtained.
Can be according to the whether serious consumption adjusting Borneolum Syntheticum and Borax of the state of an illness in actually used, even for the state of an illness
Lighter patient, it is possible to use Alumen replaces Borax.Preferably in the Chinese medicine preparation of first aspect present invention,
The weight ratio of Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, Cortex Dictamni, Borax and Borneolum Syntheticum is 30～90: 30～90:
30～90: 15～45: 15～45: 15～45: 30～90: 5～15, preferably 48～72: 48～72: 48～72:
24～36: 24～36: 24～36: 48～72: 8～12, more preferably 54～66: 54～66: 54～66: 27～33:
27～33: 27～33: 54～66: 9～11, most preferably 60: 60: 60: 30: 30: 30: 60: 10.
The preferably Chinese medicine preparation of first aspect present invention comprises it and comprises Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae
Bar and the water extract of Cortex Dictamni and Borax and Borneolum Syntheticum.In this article, term " water extract " refers to raw
Medicine can be dissolved in the material that the composition of water obtains through water extraction.Generally, (heat) decoction and can improve extraction
Efficiency.So, more preferably in the Chinese medicine preparation of first aspect present invention, extraction is to use water boiling and extraction, as
By water boiling and extraction 2 times.In the detailed description of the invention of the present invention, the Chinese medicine preparation of first aspect present invention is
By Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, the water boiling and extraction liquid of Cortex Dictamni and Borax and Borneolum Syntheticum group
Become.
In second aspect, the invention provides the preparation method of the Chinese medicine preparation of first aspect present invention, comprising:
(1) mixing Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar and Cortex Dictamni, and soak；
(2) soak obtaining step (1) decocts (preferably decocting 20～30 minutes), filters, and retains
Filtrate；
(3) filtering residue optionally obtained step (2) decocts (preferably decocting 10～20 minutes), filters, and protects
Reserved filtrate the filtrate obtained with step (2) merge；With,
(4) pulverizing Borax and Borneolum Syntheticum, the filtrate obtained with step (2) or step (3) mixes.
Preferably in the method for second aspect present invention, in step (2), the time of decoction is 20～30 points
Clock, preferably 25 minutes.
It is also preferred that in the method for second aspect present invention, in step (3), the time of decoction is 10～20
Minute, preferably 15 minutes.
In the third aspect, present invention provide for prevention or the kit for the treatment of gynaecopathia, it includes first
Container and second container, wherein the medicine in the first container includes the Chinese medicine preparation of first aspect present invention, second
Medicine in container include by Radix Sophorae Flavescentis, Cortex Dictamni, Nidus Vespae, Radix Ampelopsis, Semen setariae bar, Borneolum Syntheticum and process with Alumen standby and
Become Chinese medicine composition.
Wherein, in being prepared from by Radix Sophorae Flavescentis, Cortex Dictamni, Nidus Vespae, Radix Ampelopsis, Semen setariae bar, Borneolum Syntheticum and Alumen
In drug composition, Alumen can replace to Borax, and this is particularly suited for treating patient with severe symptoms.Preferably wherein, bitter
The weight ratio of ginseng, Cortex Dictamni, Nidus Vespae, Radix Ampelopsis, Semen setariae bar, Borneolum Syntheticum and Alumen (or Borax) is 30～90:
15～45: 15～45: 15～45: 15～45: 1.5～4.5: 2.5～7.5, preferably 48～72: 24～36: 24～36:
24～36: 24～36: 2.4～3.6: 4～6, more preferably 54～66: 27～33: 27～33: 27～33: 27～33:
2.7～3.3: 4.5～5.5, most preferably 60: 30: 30: 30: 30: 3: 5.
It is also preferred that wherein, by Radix Sophorae Flavescentis, Cortex Dictamni, Nidus Vespae, Radix Ampelopsis, Semen setariae bar, Borneolum Syntheticum and process with Alumen standby and
Chinese medicine composition is become to include Radix Sophorae Flavescentis, Cortex Dictamni, Nidus Vespae, Radix Ampelopsis and the water extract of Semen setariae bar, and/or, bag
Include Borneolum Syntheticum and Alumen (or Borax), the most finely divided ice and Alumen (or Borax).
First container and second container put together formation kit.Container can include container package and wherein
Medicine, the adjuvant of pharmaceutical acceptable can also be included further.Preferably at the medicament of third aspect present invention
In box, the medicine in the first container is configured to external wash liquid, and the medicine in second container is configured to vaginal suppository.
The present inventor studies, and can not use suppository adjuvant, and directly filled by medicine in the vaginal suppository in second container
Enter the most built-in tapon, gauze pocket or the container of cotton pocket, get final product direct thromboembolism in vagina, Ke Yijin
The convenient preparation of one step, cost-effective；Certainly, in order to increase medication compliance, the vaginal suppository in second container
In can include suppository adjuvant, such as gel adjuvant.
In fourth aspect, the invention provides the Chinese medicine preparation of first aspect present invention preparation prevention or treatment woman
Application in the medicine of section's disease.
The preferably application of fourth aspect present invention is use in conjunction, i.e. combines the application of other drug.More preferably originally
The application of invention fourth aspect be first aspect present invention Chinese medicine preparation and by Radix Sophorae Flavescentis, Cortex Dictamni, Nidus Vespae,
Radix Ampelopsis, Semen setariae bar, Borneolum Syntheticum and Alumen (or Borax) are prepared from the use in conjunction of Chinese medicine composition.
At the 5th aspect, the invention provides the kit of third aspect present invention in preparation prevention or treatment gynecological
Application in the medicine of disease.Correspondingly, at the 6th aspect, the invention provides in first aspect present invention
Medicine preparation preparation improve curative effect medicine in application, described curative effect be by Radix Sophorae Flavescentis, Cortex Dictamni, Nidus Vespae,
Radix Ampelopsis, Semen setariae bar, Borneolum Syntheticum and Alumen (or Borax) are prepared from prevention or the treatment gynecological disease of Chinese medicine composition
Sick curative effect.
Preferably in the application of the present invention the four, the 5th or the 6th aspect, gynaecopathia is cervicitis and/or vagina
Inflammation, the most described application is used for preparing prevention or treatment cervicitis and/or colpitic medicine, or wherein curative effect is
Prevent or treat cervicitis and/or colpitic curative effect.More preferably at the present invention the four, the 5th or the 6th aspect
Application in, vaginitis is colpitis mycotica, trichomonal vaginitis or bacterial vaginitis.The present invention's
In embodiment, give the treatment example of trichomonal vaginitis and monilial vaginitis, including with described
External wash liquid in kit is carried out, and then the vaginal suppository thromboembolism in described kit is entered vagina.
It is also preferred that the application of the present invention the four, the 5th or the 6th aspect is for preparing the medicine recovering pelvic floor function,
Or wherein curative effect is to recover the curative effect of pelvic floor function.More preferably answering at the present invention the four, the 5th or the 6th aspect
In with, recovering pelvic floor function is the pelvic floor function recovering puerpera.In an embodiment of the present invention, give for
The treatment example of the puerpera of vaginal delivery.
As without contrary instruction or repugnance, technical scheme and/or the technical characteristic in present invention face in the wings can
With the preferred present invention in the preferred part of front aspect.
What the present invention obtained has the beneficial effects that: the prescription of the present invention efficiently solves the Western medicine side effect such as tinidazole
And Drug resistance；Gynaecopathia can effectively be treated by the prescription of the present invention, such as vaginitis etc., even creates significantly
The effect that treatment increases, especially makes cure rate and obvious effective rate be promoted further；The prescription of the present invention can also
Stimulate vagina contraction, recover pelvic floor function, improve life quality；And, in the prescription of the present invention, Chinese medicine is raw
The kind of medicine is less, is easily controlled the quality of production, and the cost of medicine the most own is relatively low, also need not use special
Administration device, be therefore easier to popularization and application.
By specific embodiment, the present invention will be described in detail in order to make it easy to understand, following.Need spy
Not it is noted that these describe the description being merely exemplary, it is not intended that limitation of the scope of the invention.Depend on
According to the discussion of this specification, many changes of the present invention, change for one of ordinary skill in the art be all aobvious and
It is clear to.The open source literature that additionally present invention quotes is to more clearly describe the present invention, in their full text
Rong Jun includes in and carries out reference herein, just look like they full text repeated description the most in this article excessively as.
Detailed description of the invention
Illustrating below in conjunction with specific embodiment, wherein reagent and sample all can be obtained by commercial channel
, experimental procedure, if any not most part, all can be found in relevant criterion and the guide of medicine administration section, especially
The regulation of " Chinese Pharmacopoeia ", it is possible to illustrate to carry out according to the manufacturer of business-like raw material, equipment.
The preparation of embodiment 1 potentiation of the present invention external wash liquid
Take Radix Sophorae Flavescentis 60g, Radix Ampelopsis 60g, Cortex Fraxini 60g, Cortex Ailanthi 30g, Semen setariae bar 30g, Cortex Dictamni 30g addition
The water of 6 times amount of crude drug gross weight (270g), soaks 30 minutes under room temperature (20-25 DEG C), then first
Boiling with high heat, then change slow fire boiling into 25 minutes, filter, filtrate is standby；Filtering residue adds crude drug gross weight
(270g) water of 5 times amount, first boils with high heat, then changes slow fire boiling into 20 minutes, filters, filtrate
Standby.Merge twice filtrate, be divided into nine bags of subpackages, every bag of 230mL, if amount of filtrate is too much, permissible
The filtrate of merging is concentrated in rotary evaporator, by standby for the filtrate cold preservation of subpackage.Separately take Borax 60g
With Borneolum Syntheticum 10g, decile after pulverizing, mix with the filtrate of above-mentioned subpackage, be external wash liquid, can put into immediately
Use.
The preparation of embodiment 2 vaginal suppository
Take Radix Sophorae Flavescentis 60g, Cortex Dictamni 30g, Nidus Vespae 30g, Radix Ampelopsis 30g and Semen setariae bar 30g, add crude drug total
The water of weight 8 (180g) times amount, soaks 1 hour under room temperature (20-25 DEG C), is fried boiling 2 hours, filters,
Filtrate is standby；Filtering residue adds the water of 6 times amount of crude drug gross weight (180g), is fried boiling 2 hours, filters, filter
Liquid is standby；Filtering residue adds the water of 6 times amount of crude drug gross weight (180g), is fried boiling 1.5 hours, filters, filter
Liquid is standby.Merge three filtrates, carry out being concentrated into thick extractum in rotary evaporator, be then placed in vacuum decompression
Carry out in drying baker being dried with 85 DEG C, obtain dry extract, then pulverize and be dried, there are the extract of about 50g.
Take Borneolum Syntheticum 3g and Alumen 5g, be ground into fine powder (e.g., 120 mesh sieves can be crossed) with above-mentioned 50 grams of extracts,
Mix homogeneously, takes 2.32g and pours in the built-in tapon that one end seals, and the other end (beginning end) is with thin
Line fastens, and reserves the end of a thread (filling in the extraction of vagina back guy to facilitate) of about 10cm length, is derived from
Vaginal suppository I.
For the patient's (substantially with cervical erosion) using vaginal suppository I mono-not improve the course for the treatment of, can make
Replacing above-mentioned Alumen with Borax 5g, other preparation methods are identical, are derived from vaginal suppository II.
The effectiveness study of embodiment 3 trichomonal vaginitis
Clinical diagnosis suffers from women's case of trichomonal vaginitis, is randomly divided into three groups: (1) therapeutic alliance group,
38 examples, use the external wash liquid prepared according to the method for embodiment 1 and prepare according to the method for embodiment 2
Vaginal suppository I, has two patients of cervical ruin reports invalid after a course for the treatment of, is then made into by vaginal suppository I
Vaginal suppository II continues a course for the treatment of (but being not counted in following table result)；(2) suppository in treatment group, 25 examples, use
Clear water and according to vaginal suppository I prepared by the method for embodiment 2, has two cervical erosion to suffer from after a course for the treatment of
Person reports invalid, vaginal suppository I makes into vaginal suppository II then and continues a course for the treatment of (but being not counted in following table result)；
(3) western medicine group, 9 examples, use tinidazole.
Owing to patient's many is not equipped with vaginal douche, the therefore unified demibain method use washing liquid that uses, the most just before going to bed
Before, clean external genital recoil in washing liquid or clear water 5 minutes, stretch into vagina wiping with gauze or finger simultaneously；
Then dry, suppository is filled in vagina, pull out after within second day, getting up and discard.Tinidazole is pressed package insert and is used.
One 12 days course for the treatment of, prohibitive life during medication.
The result of one course of therapy is as shown in table 1, and wherein evaluation criterion is: cure: after treatment and treatment one
Vaginitis clinical symptom disappearance after individual month, and infusorian cultivate be negative；Effective: vaginitis clinical symptoms after treatment
Disappear, and infusorian is cultivated and is negative, but after treating one month, infusorian cultivation is positive；Effective: cloudy after treatment
Road inflammation clinical symptoms significantly improves, but infusorian is cultivated and is positive；Invalid: after treatment vaginitis clinical symptoms without
Significantly improve, and infusorian is cultivated and is positive.Total effective rate calculates with healing, effective and effective summation.
The comparitive study of table 1 trichomonal vaginitis
Do not have patient to report side effect and untoward reaction in the treatment of a course for the treatment of, in following up a case by regular visits to, the most do not find pair
Effect and untoward reaction.According to the result of table 1, through the treatment of a course for the treatment of, therapeutic alliance group total effectively
Rate is compared other two groups and is increased, and the raising especially comparing suppository in treatment group is limited；But, if it is considered that fully recover from an illness
More with effective general effect (these effects have the infusorian after treatment to cultivate checking, and effect is the most definite), especially
It is recovery from illness effect, and compound treatment group is than suppository in treatment group, and potentiation is notable.It addition, for compound treatment
Two invalid patients in group, one course for the treatment of of continual cure after using vaginal suppository II instead, all in effective curative effect.
The colpitic effectiveness study that embodiment 4 monilial infection causes
Colpitic women's case that clinical diagnosis causes due to monilial infection, is randomly divided into three groups: (1)
Therapeutic alliance group, 11 examples, use the external wash liquid prepared according to the method for embodiment 1 and according to embodiment 2
The vaginal suppository I for preparing of method；(2) suppository in treatment group, 7 examples, use clear water and according to embodiment 2
Vaginal suppository I prepared by method；(3) western medicine group, 3 examples, use tinidazole.Route of administration and the course for the treatment of
Identical with embodiment 3.
The result of one course of therapy is as shown in table 2, and wherein evaluation criterion is: cure: after treatment and treatment one
Vaginitis clinical symptom disappearance after individual month, and candidiasis cultivate be negative；Effective: vaginitis clinical condition after treatment
Shape disappears, and candidiasis is cultivated and is negative, but after treating one month, candidiasis cultivation is positive；Effective: to control
After treatment, vaginitis clinical symptoms significantly improves, but candidiasis is cultivated and is positive；Invalid: after treatment, vaginitis faces
Bed symptom is without significantly improving, and candidiasis is cultivated and is positive.Total effective rate is with healing, effective and effective summation
Calculate.
The comparitive study of table 2 monilial vaginitis
Do not have patient to report side effect and untoward reaction in the treatment of a course for the treatment of, in following up a case by regular visits to, the most do not find pair
Effect and untoward reaction.According to the result of table 2, through the treatment of a course for the treatment of, therapeutic alliance group total effectively
Rate is similar to other two groups；But, if it is considered that recovery from illness and effective general effect are (after these effects have treatment
Candidiasis cultivate checking, effect is the most definite), effect of especially fully recovering, compound treatment group is than other two groups
It is obviously improved.
The research that embodiment 5 puerpera's pelvic floor function recovers
31 vaginal delivery puerperas in puerperal 42～56 days, are randomly divided into two groups of (Pelvic floor pressure inspections before treatment
Survey without significant difference): (1) treatment group, 16 examples, use the external wash liquid prepared according to the method for embodiment 1
With the vaginal suppository I prepared according to the method for embodiment 2, after a course for the treatment of, disable 2 days, then carry out one
The individual course for the treatment of, carry out 4 courses for the treatment of the most altogether；(2) matched group, 15 examples, do not use and natural through 8 weeks.
One 12 days course for the treatment of, every day period, route of administration was identical with embodiment 3, with PHENIX electricity before and after treatment
The pressure probe of stimulating organism feedback treating instrument carries out pressure detecting to Pelvic floor, and result is as shown in table 3.
Table 3 puerpera's pelvic floor function recovery situation
Pelvic floor recovery situation through the puerpera of four course of therapy is significantly better than the matched group of the same period, shows to use
The external wash liquid therapeutic alliance of the present invention can remarkably promote pelvic floor function and recover, and promotes vagina contraction, can be used for
Treatment pelvic floor dysfunction.It addition, treatment terminates showing with access volume of the later moon, treatment group has 75%
Represent and sexual life is satisfied with, and matched group only has 33% expression and is satisfied with sexual life, this further demonstrates this
Effect recovering pelvic floor function of bright external wash liquid associating suppository in treatment.
Claims (32)
1. for preventing or treat the Chinese medicine preparation of gynaecopathia, it is prepared from by following crude drug: Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, Cortex Dictamni, Borax and Borneolum Syntheticum, and wherein the weight ratio of Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, Cortex Dictamni, Borax and Borneolum Syntheticum is 30～90: 30～90: 30～90: 15～45: 15～45: 15～45: 30～90: 5～15.
2. the Chinese medicine preparation described in claim 1, wherein the weight ratio of Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, Cortex Dictamni, Borax and Borneolum Syntheticum is 48～72: 48～72: 48～72: 24～36: 24～36: 24～36: 48～72: 8～12.
3. the Chinese medicine preparation described in claim 2, wherein the weight ratio of Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, Cortex Dictamni, Borax and Borneolum Syntheticum is 54～66: 54～66: 54～66: 27～33: 27～33: 27～33: 54～66: 9～11.
4. the Chinese medicine preparation described in claim 3, wherein the weight ratio of Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, Cortex Dictamni, Borax and Borneolum Syntheticum is 60: 60: 60: 30: 30: 30: 60: 10.
5. the Chinese medicine preparation described in claim 1, it comprises Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar and the water extract of Cortex Dictamni and Borax and Borneolum Syntheticum.
6. the Chinese medicine preparation described in claim 5, its water boiling and extraction liquid comprising Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar and Cortex Dictamni and Borax and Borneolum Syntheticum.
7. for preventing or treat the Chinese medicine preparation of gynaecopathia, it is prepared from by following crude drug: Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, Cortex Dictamni, Alumen and Borneolum Syntheticum, and wherein the weight ratio of Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, Cortex Dictamni, Alumen and Borneolum Syntheticum is 30～90: 30～90: 30～90: 15～45: 15～45: 15～45: 30～90: 5～15.
8. the Chinese medicine preparation described in claim 7, wherein the weight ratio of Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, Cortex Dictamni, Alumen and Borneolum Syntheticum is 48～72: 48～72: 48～72: 24～36: 24～36: 24～36: 48～72: 8～12.
9. the Chinese medicine preparation described in claim 8, wherein the weight ratio of Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, Cortex Dictamni, Alumen and Borneolum Syntheticum is 54～66: 54～66: 54～66: 27～33: 27～33: 27～33: 54～66: 9～11.
10. the Chinese medicine preparation described in claim 9, wherein the weight ratio of Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar, Cortex Dictamni, Alumen and Borneolum Syntheticum is 60: 60: 60: 30: 30: 30: 60: 10.
Chinese medicine preparation described in 11. claim 6, it comprises Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar and the water extract of Cortex Dictamni and Alumen and Borneolum Syntheticum.
Chinese medicine preparation described in 12. claim 5, its water boiling and extraction liquid comprising Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar and Cortex Dictamni and Alumen and Borneolum Syntheticum.
The preparation method of arbitrary described Chinese medicine preparation of 13. claim 1～12, comprising:
(1) mixing Radix Sophorae Flavescentis, Radix Ampelopsis, Cortex Fraxini, Cortex Ailanthi, Semen setariae bar and Cortex Dictamni, and soak；
(2) soak obtaining step (1) decocts, and filters, and retains filtrate；
(3) filtering residue optionally obtained step (2) decocts, and filters, and reservation filtrate the filtrate obtained with step (2) merge；With,
(4) pulverizing Borax or Alumen, and pulverize Borneolum Syntheticum, the filtrate obtained with step (2) or step (3) mixes.
Preparation method described in 14. claim 13, is wherein to decoct 20～30 minutes in step (2).
Preparation method described in 15. claim 13, is wherein to decoct 10～20 minutes in step (3).
16. for preventing or treat the kit of gynaecopathia, it includes the first container and second container, wherein the medicine in the first container includes the arbitrary described Chinese medicine preparation of claim 1～12, and the medicine in second container includes the medicine being prepared from Chinese medicine composition or second container by Radix Sophorae Flavescentis, Cortex Dictamni, Nidus Vespae, Radix Ampelopsis, Semen setariae bar, Borneolum Syntheticum and Alumen to include by Radix Sophorae Flavescentis, Cortex Dictamni, Nidus Vespae, Radix Ampelopsis, Semen setariae bar, Borneolum Syntheticum and Borax being prepared from Chinese medicine composition.
Kit described in 17. claim 16, wherein the medicine in the first container is configured to external wash liquid, and the medicine in second container is configured to vaginal suppository.
The application in the medicine of preparation prevention or treatment cervicitis and/or vaginitis and/or recovery pelvic floor function of the arbitrary described Chinese medicine preparation of 18. claim 1～12.
Application described in 19. claim 18, wherein vaginitis is colpitis mycotica, trichomonal vaginitis or bacterial vaginitis.
Application described in 20. claim 18, wherein recovering pelvic floor function is the pelvic floor function recovering puerpera.
Application described in 21. claim 18, it is use in conjunction.
Application described in 22. claim 21, it is the arbitrary described Chinese medicine preparation of claim 1～12 and is prepared from the use in conjunction of Chinese medicine composition by Radix Sophorae Flavescentis, Cortex Dictamni, Nidus Vespae, Radix Ampelopsis, Semen setariae bar, Borneolum Syntheticum and Alumen.
Application described in 23. claim 21, it is the arbitrary described Chinese medicine preparation of claim 1～12 and is prepared from the use in conjunction of Chinese medicine composition by Radix Sophorae Flavescentis, Cortex Dictamni, Nidus Vespae, Radix Ampelopsis, Semen setariae bar, Borneolum Syntheticum and Borax.
The application in the medicine of preparation prevention or treatment cervicitis and/or vaginitis and/or recovery pelvic floor function of the kit described in 24. claim 16 or 17.
Application described in 25. claim 24, wherein vaginitis is colpitis mycotica, trichomonal vaginitis or bacterial vaginitis.
Application described in 26. claim 24, wherein recovering pelvic floor function is the pelvic floor function recovering puerpera.
The application in preparation improves the medicine of curative effect of the arbitrary described Chinese medicine preparation of 27. claim 1～12, described curative effect is to be prepared from the prevention of Chinese medicine composition by Radix Sophorae Flavescentis, Cortex Dictamni, Nidus Vespae, Radix Ampelopsis, Semen setariae bar, Borneolum Syntheticum and Alumen or treat cervicitis and/or vaginitis and/or recover the curative effect of pelvic floor function.
Application described in 28. claim 27, wherein vaginitis is colpitis mycotica, trichomonal vaginitis or bacterial vaginitis.
Application described in 29. claim 27, wherein recovering pelvic floor function is the pelvic floor function recovering puerpera.
The application in preparation improves the medicine of curative effect of the arbitrary described Chinese medicine preparation of 30. claim 1～12, described curative effect is to be prepared from the prevention of Chinese medicine composition by Radix Sophorae Flavescentis, Cortex Dictamni, Nidus Vespae, Radix Ampelopsis, Semen setariae bar, Borneolum Syntheticum and Borax or treat cervicitis and/or vaginitis and/or recover the curative effect of pelvic floor function.
Application described in 31. claim 30, wherein vaginitis is colpitis mycotica, trichomonal vaginitis or bacterial vaginitis.
Application described in 32. claim 30, wherein recovering pelvic floor function is the pelvic floor function recovering puerpera.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1452868A (en) * | 2002-04-24 | 2003-11-05 | 宋廷生 | Skin disinfectant for external use prepn process |
| CN101254288A (en) * | 2007-03-02 | 2008-09-03 | 赵朝群 | Applications of Chinese medicinal composition for curing colpitis medicament |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1452868A (en) * | 2002-04-24 | 2003-11-05 | 宋廷生 | Skin disinfectant for external use prepn process |
| CN101254288A (en) * | 2007-03-02 | 2008-09-03 | 赵朝群 | Applications of Chinese medicinal composition for curing colpitis medicament |
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