CN105560820A - Failure inhibiting recovery decoction for inhibiting premature ovarian failure - Google Patents

Failure inhibiting recovery decoction for inhibiting premature ovarian failure Download PDF

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CN105560820A
CN105560820A CN201610138368.3A CN201610138368A CN105560820A CN 105560820 A CN105560820 A CN 105560820A CN 201610138368 A CN201610138368 A CN 201610138368A CN 105560820 A CN105560820 A CN 105560820A
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radix
failure
fructus
inhibiting
premature ovarian
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秦佳佳
刘海全
杨静
梁嘉丽
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Abstract

The invention provides a failure inhibiting recovery decoction for inhibiting premature ovarian failure, which is safe in medication, has no toxic and side effects and has an obvious treatment effect. The failure inhibiting recovery decoction is prepared from the following recipe in parts by weight: 10 g of radix scrophulariae, 10 g of dried radix rehmanniae, 20 g of cuscutae semen, 20 g of lycii fructus, 10 g of rubi fructus, 10 g of semen plantaginis, 5 g of schisandrae chinensis fructus, 10 g of radix ophiopogonis, 30 g of radix astragali seu hedysari, 10 g of trogopterus dung, 10 g of galli gigerii endothelium corneum, 10 g of radix angelicae sinensis and 20 g of rhizoma dioscoreae. After the solution of the invention is adopted, the recipe of the failure inhibiting recovery decoction provided by the invention has effects of nourishing yin, replenishing essence, tonifying kidney, tonifying qi, nourishing blood and promoting blood circulation; moreover, by adopting a method of combining strengthening body resistance with purgation, the recipe in the solution has functions of strengthening body resistance without retaining evil and conquering nidus without hurting body resistance, and has a good effect in clinical application.

Description

But a kind of multiple soup that declined suppressing premature ovarian failure of women
Technical field
The present invention relates to technical field of Chinese medicines, but refer in particular to a kind of multiple soup that declined suppressing premature ovarian failure of women.
Background technology
Premature ovarian failure (Prematureovarianfailure), is called for short POF, refer to the amenorrhea that women caused because of certain reason with front at 40 years old, infertile, estrogen deficiency, and ovariectomized rats raises a kind of disease for feature.Patients is amenorrhea, infertile clinically, has flushed face concurrently, hectic fever hyperhidrosis, anxious state of mind, leucorrhea reduce.
Premature ovarian failure is that one of women's health threatens greatly, the misery that a lot of women is brought by premature ovarian failure throughout the year.The harm of premature ovarian failure mainly contains following 5 points: one, easily suffer from tumor, and premature ovarian failure can increase the probability, the particularly disease such as cervical cancer, ovarian tumor that female patient suffers from tumor greatly; Two, vascular dysfunctions, chain reaction in patients with premature ovarian there will be perspiration, fear of cold, also can simultaneously with cardiopalmus, uncomfortable in chest, breathe hard and the symptom such as dizzy; Three, the mental status is poor, and chain reaction in patients with premature ovarian often has worry, depression, emotional, insomnia, bitter, hypomnesis, the symptom such as absent-minded; Four, menoxenia, amenorrhea, the menstrual cycle of ovary patient can get muddled, and menostaxis, even there will be the phenomenon that menstruation stops suddenly; Five, infertile, this is premature ovarian failure is serious harm, and premature ovarian failure makes female patient occur amenorrhea phenomenon, and amenorrhea can affect ovulation, and then causes infertile.
Premature ovarian failure reason is complicated, mainly contains: inherited genetic factors, natural immunity factor, living habit and bearing status etc.At present, no matter be the traditional Chinese medical science or doctor trained in Western medicine, very effective medicine be there is no for premature ovarian failure.But find through Chinese medical etiology investigation, suffer from a deficiency of the kidney plays a leading role in premature ovarian failure, and deficiency of kidney-QI, kidney essense scarcity is its main pathogenesis, stagnation of liver-QI with deficiency of the spleen, and QI and blood secretly consumes, qi depression to blood stasis, Chong and Ren channel disorder etc. are its important pathogenesis.Therefore, in view of this, effectively can treat premature ovarian failure of women, drug safety for how searching out one, to have no side effect and the significant medicine of therapeutic effect just seems particularly important.
Summary of the invention
For the deficiencies in the prior art, but the invention provides a kind of drug safety, without secondary toxic action and therapeutic effect significantly for suppressing the multiple soup that declined of premature ovarian failure of women.
For achieving the above object, technical scheme provided by the present invention is: but a kind of multiple soup that declined suppressing premature ovarian failure of women, it is characterized in that: be made up of the formula according to following weight portion: 10g Radix Scrophulariae, the 10g Radix Rehmanniae, 20g Semen Cuscutae, 20g Fructus Lycii, 10g Fructus Rubi, 10g Semen Plantaginis, 5g Fructus Schisandrae Chinensis, 10g Radix Ophiopogonis, the 30g Radix Astragali, 10g Oletum Trogopterori, 10g Endothelium Corneum Gigeriae Galli, 10g Radix Angelicae Sinensis and 20g Rhizoma Dioscoreae.
Simultaneously, but the present invention also provides the multiple soup that declined for premature ovarian failure of women processed of another kind of recipe ratio, it is characterized in that: be made up of the formula according to following weight portion: 10g Radix Scrophulariae, the 10g Radix Rehmanniae, 30g Semen Cuscutae, 30g Fructus Lycii, 10g Fructus Rubi, 10g Semen Plantaginis, 5g Fructus Schisandrae Chinensis, 10g Radix Ophiopogonis, the 30g Radix Astragali, 15g Oletum Trogopterori, 20g Endothelium Corneum Gigeriae Galli, 10g Radix Angelicae Sinensis and 30g Rhizoma Dioscoreae.
Equally, but present invention also offers the multiple soup that declined for premature ovarian failure of women processed of another kind of recipe ratio, it is characterized in that: be made up of the formula according to following weight portion: 10g Radix Scrophulariae, the 10g Radix Rehmanniae, 15g Semen Cuscutae, 15g Fructus Lycii, 10g Fructus Rubi, 10g Semen Plantaginis, 5g Fructus Schisandrae Chinensis, 10g Radix Ophiopogonis, the 30g Radix Astragali, 10g Oletum Trogopterori, 10g Endothelium Corneum Gigeriae Galli, 10g Radix Angelicae Sinensis and 15g Rhizoma Dioscoreae.
The present invention is after have employed such scheme, and its great advantage is that we have YIN nourishing replenishing essence, tonifies Qi of the kidney, the effect of nourishing blood and promoting blood circulation.The treatment of current premature ovarian failure, most doctor all with the ruling by law of kidney tonifying, essence replenishing it.And found by clinical observation, premature ovarian failure is with many functions pathological changes of ovarian failure, decrease in estrogen induction, and absorbed the kidney invigorating can not this sick essence of comprehensive solution.Therefore its pharmaceutical formulation in this programme is based on the kidney invigorating, takes into account lung, spleen two is dirty, benefiting qi and nourishing yin, nourshing blood and promoting blood circulation, merit is specially imitated entirely, clinically often obtains special effect, simultaneously reinforcement and elimination in combination, be association of activity and inertia, tonify without causing stagnation, attack and do not hinder.Consider premature ovarian failure patient mostly the course of disease with the passing of time, impairment of both QI and YIN, again because of the many stasis of bloods of prolonged illness, therefore sufferer is main, simulataneous insufficiency and excessive mainly with void greatly; If nourish simply, then blood stasis is difficult to walk, blockage of main and collateral channels, puckery under not through water; If storm simply, consume the moon of feeling frustrated further again, break its stream in source, breaks off through water.In view of this, the formula in this programme is by taking righting and capturing the method combined, and righting do not stay heresy, attack enemy is not just hindering, and clinical practice, effect is excellent.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described.
But this programme provides a kind of multiple soup that declined suppressing premature ovarian failure of women, for the female group of body weight between 45kg to 75kg, this formula is made up of the formula according to following weight portion: 10g Radix Scrophulariae, the 10g Radix Rehmanniae, 20g Semen Cuscutae, 20g Fructus Lycii, 10g Fructus Rubi, 10g Semen Plantaginis, 5g Fructus Schisandrae Chinensis, 10g Radix Ophiopogonis, the 30g Radix Astragali, 10g Oletum Trogopterori, 10g Endothelium Corneum Gigeriae Galli, 10g Radix Angelicae Sinensis and 20g Rhizoma Dioscoreae.
The female group of 45kg is less than for body weight, but the above-mentioned multiple soup that declined, its formula is made up of the formula according to following weight portion: 10g Radix Scrophulariae, the 10g Radix Rehmanniae, 15g Semen Cuscutae, 15g Fructus Lycii, 10g Fructus Rubi, 10g Semen Plantaginis, 5g Fructus Schisandrae Chinensis, 10g Radix Ophiopogonis, the 30g Radix Astragali, 10g Oletum Trogopterori, 10g Endothelium Corneum Gigeriae Galli, 10g Radix Angelicae Sinensis and 15g Rhizoma Dioscoreae.
The female group of 75kg is overweighted for body weight, but the above-mentioned multiple soup that declined, its formula is made up of the formula according to following weight portion: 10g Radix Scrophulariae, the 10g Radix Rehmanniae, 30g Semen Cuscutae, 30g Fructus Lycii, 10g Fructus Rubi, 10g Semen Plantaginis, 5g Fructus Schisandrae Chinensis, 10g Radix Ophiopogonis, the 30g Radix Astragali, 15g Oletum Trogopterori, 20g Endothelium Corneum Gigeriae Galli, 10g Radix Angelicae Sinensis and 30g Rhizoma Dioscoreae.
Above-mentioned formula in this programme is made up of 13 taste medicines, and Semen Cuscutae, Fructus Lycii, Fructus Rubi, Semen Plantaginis, Fructus Schisandrae Chinensis are monarch drug; Radix Scrophulariae, Radix Ophiopogonis, the Radix Rehmanniae, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Endothelium Corneum Gigeriae Galli are ministerial drug, and Oletum Trogopterori, Endothelium Corneum Gigeriae Galli are adjuvant drug.For the combining form of above-mentioned formula, it should be noted that, the Radix Rehmanniae, Radix Scrophulariae mutual reinforcement between adapted have benefit in clear at this, invigorating middle warmer is short clear, the power multiplication of its clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Radix Scrophulariae, the Radix Astragali 5 use, temperature compensation, Liang Run phase are helped, QI invigorating, nourishing YIN and clearing away heat; Semen Cuscutae, Fructus Lycii, Fructus Rubi, Semen Plantaginis, Fructus Schisandrae Chinensis invigorating middle warmer are resided puckery, hold concurrently logical, play the merit of the kidney invigorating and essence nourishing altogether in puckery; Rhizoma Dioscoreae, Endothelium Corneum Gigeriae Galli are referred and synthesized, and one mends one disappears, and mends the combination that disappears, plays nourishing spleen and stomach altogether, the raw merit of promoting blood circulation of money; The Radix Astragali, Radix Angelicae Sinensis share, and QI and blood is mended altogether, are association of activity and inertia, and play the energy of benefiting QI and nourishing blood altogether.
Table 1
Ginseng is shown in Table 1, and in this programme, most of medical instrument has antipyretic, antiinflammatory, blood sugar lowering, immunity moderation and anti-ageing pharmacological action of waiting for a long time, and clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting effect may be relevant with it.Concrete: the medicine such as Fructus Lycii, Semen Cuscutae, Fructus Rubi mostly has defying age, strengthens immunity, promotes the pharmacological action such as bone marrow hematogenesis and protection optic nerve, and the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity effect may be relevant to it.
Radix Scrophulariae has antiinflammatory and bactericidal action, can reduce capillary permeability, excited adrenal cortex function, also has immunity moderation, cooling, removing toxic substances, hypoglycemic effect; In Radix Scrophulariae, Phenylpropanoid Glycosides glycosides has hepatoprotective effect.
Radix Rehmanniae can resist the decline of taking plasma corticosterone concentration after dexamethasone continuously, and can prevent and treat Adrenal cortex atrophy.Clinical discovery Radix Rehmanniae and glucocorticoid share the side effect that can reduce the hyperactivity of YANG due to deficiency of YIN that hormone causes.Glucocorticoid surplus " deficiency of YIN " the model mice macrophage that Radix Rehmanniae can obviously suppress corticosterone intramuscular injection to be induced is to the high level expression of the Ia antigen that IFN-γ induces, prompting Radix Rehmanniae has certain immunosuppressive action, and suppress Macrophage Surface Ia antigenic expression, reduce its antigenic capacity.Bosom Dihuang polysaccharide can the atrophy of obviously exhausted mining areas thymus and spleen caused by antagonism D-galactose, related immune index such as thymic cortex thickness and cell number, splenic nodule and lymphocyte number is even made obviously to raise, so that exceed normal level, prompting bosom Dihuang polysaccharide may be the antidotal main active of bosom Radix Rehmanniae tonification, can the atrophy of antagonism exhausted mining areas immune organ, strengthen immunity.By mice swimming and anoxia enduring experiment, show that Fructus Schisandrae Chinensis crude polysaccharides can significantly improve mice swimming and hypoxia endurance time, there is certain antifatigue effect.Get Fructus Schisandrae Chinensis 2 to 3g/kg lumbar injection, significantly can increase the weight of mouse testis, point out, to mouse sexual function, there is certain facilitation.Fructus Schisandrae Chinensis Aqueous extracts makes adult mice testicular weight add 57.1%, make curved fine extract tube diameter increase by 41%, and under light microscopic, the number of plies of spermatogenic cell and the quantity of sperm increases to some extent, proves that Fructus Schisandrae Chinensis has and promotes spermatogenetic effect.Utilize Semen Cuscutae flavonoid gastric infusion, rat ovary, uterus weight can be increased, strengthen hCG/LH function of receptors, strengthen hypophysis to the reactivity of gonadotropin releasing hormone (LRH), promote isolated culture people villi hCG secretion.Fructus Rubi aqueous extract can reduce hypothalamic LHRH, the level of hypophysis LF, FSH and gonad E2, raise testosterone level.Pharmacological evaluation shows, Fructus Rubi has antibacterial and oestrogen-like hormone effect.Its decoct has inhibitory action to staphylococcus, also has inhibitory action to vibrio cholera.Make observation index with vaginal smear and inner membrance section, Fructus Rubi seemingly has estrogen-like effects.50 μ l are injected in plantago asiatica linne polyoses intravaginal, after continuous 7 days, can significantly improve its lactobacillus quantity to vaginal dysbacteriosis model mice.Oletum Trogopterori water extract (1g/ml) 0.5ml adds 5 μ l epinephrine topicals, arteriole restoration of blood flow can be promoted to the experimental microcirculation disturbance display of mice mesentery, arteriole is suppressed to shrink incidence rate, alleviate the shrinkage degree in arteriole footpath, sick promoting the recovery after shrinking, is that local microcirculation obviously shortens recovery time.Remarkable with matched group comparing difference, prompting has good improving micro_circulation effect.Endothelium Corneum Gigeriae Galli has anticoagulant and changes hemorheological effect.Endothelium Corneum Gigeriae Galli can alleviate atherosclerosis.After rabbit gavages Endothelium Corneum Gigeriae Galli, in its blood, PT is without significant change, APTT and TT, apparently higher than normal group, shows that Endothelium Corneum Gigeriae Galli has inhibitory action to blood coagulation system.Many animals is pregnant, the isolated uterine of unpregnancy, Uterus in vivo and chronic uterus fistula experiment prove, Radix Angelicae Sinensis to uterus have " amphicheirality " effect.Radix Angelicae Sinensis is containing excited uterus and suppress two kinds, uterus composition, is respectively nonvolatile matter and the quintessence oil of water solublity or alcohol dissolubility, and Chinese medicine angelica quintessence oil suppresses the effective ingredient of uterine smooth muscle may be ligustilide.Angelica essential oil can suppress the spontaneous contractions side of isolated rabbit, rat, Canis familiaris L. uterine smooth muscle, can resist the excitement that second phthalein choline causes, also can partly to the contraction that antiadrenergic drug causes.Water decoction of Angelica sinensis has excitation to isolated mouse uterus, and this is relevant with the excitation of Radix Angelicae Sinensis to uterus histamine H1-receptor, but has nothing to do with prostaglandin synthetase in uterus muscle.Rhizoma Dioscoreae has to be alleviated gastrointestinal smooth muscular spasm and resists neurohumoral effect, and fresh yam extract can promote the reparation of gastric mucosa.
The examples of implementation of the above are only the preferred embodiment of the present invention, not limit practical range of the present invention with this, therefore all changes done according to the principle of the present invention, all should be encompassed in protection scope of the present invention.

Claims (3)

  1. But 1. suppress the multiple soup that declined of premature ovarian failure of women, it is characterized in that: be made up of the formula according to following weight portion: 10g Radix Scrophulariae, the 10g Radix Rehmanniae, 20g Semen Cuscutae, 20g Fructus Lycii, 10g Fructus Rubi, 10g Semen Plantaginis, 5g Fructus Schisandrae Chinensis, 10g Radix Ophiopogonis, the 30g Radix Astragali, 10g Oletum Trogopterori, 10g Endothelium Corneum Gigeriae Galli, 10g Radix Angelicae Sinensis and 20g Rhizoma Dioscoreae.
  2. But 2. suppress the multiple soup that declined of premature ovarian failure of women, it is characterized in that: be made up of the formula according to following weight portion: 10g Radix Scrophulariae, the 10g Radix Rehmanniae, 30g Semen Cuscutae, 30g Fructus Lycii, 10g Fructus Rubi, 10g Semen Plantaginis, 5g Fructus Schisandrae Chinensis, 10g Radix Ophiopogonis, the 30g Radix Astragali, 15g Oletum Trogopterori, 20g Endothelium Corneum Gigeriae Galli, 10g Radix Angelicae Sinensis and 30g Rhizoma Dioscoreae.
  3. But 3. suppress the multiple soup that declined of premature ovarian failure of women, it is characterized in that: be made up of the formula according to following weight portion: 10g Radix Scrophulariae, the 10g Radix Rehmanniae, 15g Semen Cuscutae, 15g Fructus Lycii, 10g Fructus Rubi, 10g Semen Plantaginis, 5g Fructus Schisandrae Chinensis, 10g Radix Ophiopogonis, the 30g Radix Astragali, 10g Oletum Trogopterori, 10g Endothelium Corneum Gigeriae Galli, 10g Radix Angelicae Sinensis and 15g Rhizoma Dioscoreae.
CN201610138368.3A 2016-03-11 2016-03-11 Failure inhibiting recovery decoction for inhibiting premature ovarian failure Pending CN105560820A (en)

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Citations (2)

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Publication number Priority date Publication date Assignee Title
CN1682875A (en) * 2005-02-15 2005-10-19 朱本君 Chinese medicine composition for treating infertility of male and female
CN104056007A (en) * 2014-06-29 2014-09-24 苟晓龙 Sperm promoting capsule

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
CN1682875A (en) * 2005-02-15 2005-10-19 朱本君 Chinese medicine composition for treating infertility of male and female
CN104056007A (en) * 2014-06-29 2014-09-24 苟晓龙 Sperm promoting capsule

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王忠英: "谢亚莉教授运用五子衍宗丸加减治疗卵巢早衰之经验总结", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 *

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